Best TWAS P=1.07e-15 · Best GWAS P=3.1e-11 conditioned to 0.00663
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GLDN | 0.26 | 0.00 | bslmm | 502 | 0.06 | 7.6e-08 | 0.31 | -5.9 | 4.8e-09 | -0.51 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-707P17.2 | 0.23 | 0.16 | enet | 13 | 0.16 | 1.6e-08 | 5.10 | 5.3 | 1.3e-07 | 0.48 | 0.95 | 0.05 | FALSE |
| 3 | GTEx | Muscle Skeletal | RP11-707P17.2 | 0.15 | 0.07 | lasso | 4 | 0.04 | 1.7e-04 | 5.05 | 5.2 | 2.5e-07 | 0.49 | 0.93 | 0.07 | FALSE |
| 4 | NTR | Blood | AP4E1 | 0.02 | 0.00 | blup | 499 | 0.01 | 7.7e-05 | -3.19 | 8.0 | 1.1e-15 | 0.33 | 0.29 | 0.11 | TRUE |
| 5 | YFS | Blood | AP4E1 | 0.08 | 0.05 | lasso | 7 | 0.07 | 1.1e-22 | 3.82 | 5.3 | 1.4e-07 | 0.09 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CYP19A1 | 0.04 | 0.00 | blup | 209 | 0.01 | 2.3e-02 | -1.80 | -5.2 | 2.3e-07 | -0.12 | 0.09 | 0.02 | FALSE |