[Hub]/) : Traits : Lung FVC : ← →

chr15:66,797,492-69,178,312

Best TWAS P=4.4e-16 · Best GWAS P=3.63e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	-7.3	-7.1	1.5e-12	0.93	0.02	0.98	TRUE
2	CommonMind	Brain Pre-frontal Cortex	IQCH	0.13	0.11	bslmm	597	0.10	5.9e-12	-8.3	7.9	4.0e-15	-0.84	0.04	0.96	TRUE
3	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-5.5	5.6	2.5e-08	-0.65	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-5.6	5.5	4.0e-08	-0.66	0.42	0.32	FALSE
5	GTEx	Artery Aorta	PIAS1	0.26	0.12	enet	22	0.10	3.4e-06	-6.0	5.6	1.7e-08	-0.12	0.01	0.99	FALSE
6	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-5.6	5.2	1.7e-07	-0.66	0.25	0.61	FALSE
7	GTEx	Artery Tibial	PIAS1	0.14	0.02	enet	26	0.08	1.6e-06	-2.5	5.5	3.6e-08	-0.15	0.16	0.82	FALSE
8	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-5.6	5.8	8.2e-09	-0.67	1.00	0.00	FALSE
9	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-8.4	8.1	4.4e-16	-0.92	0.03	0.94	TRUE
10	GTEx	Brain Hippocampus	IQCH-AS1	0.20	0.08	enet	11	0.05	2.2e-02	4.4	-5.2	2.2e-07	0.42	0.14	0.23	FALSE
11	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-5.6	6.0	2.4e-09	-0.69	0.38	0.62	FALSE
12	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-5.5	5.3	9.9e-08	-0.58	0.75	0.23	FALSE
13	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-5.5	5.4	8.0e-08	-0.64	0.59	0.35	FALSE
14	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	4.7	5.2	1.6e-07	-0.52	0.97	0.02	FALSE
15	GTEx	Nerve Tibial	PIAS1	0.20	0.10	lasso	8	0.14	3.0e-10	-5.7	5.7	1.3e-08	-0.17	0.03	0.97	TRUE
16	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-5.6	5.6	2.7e-08	-0.64	1.00	0.00	FALSE
17	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-5.5	6.0	2.5e-09	-0.69	0.13	0.69	FALSE
18	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	4.7	5.8	6.4e-09	-0.56	0.87	0.12	FALSE
19	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-5.5	5.8	8.3e-09	-0.67	0.98	0.02	FALSE
20	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	-5.7	5.2	1.6e-07	-0.61	0.16	0.81	FALSE
21	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-5.5	5.4	5.1e-08	-0.64	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-5.5	7.1	9.8e-13	-0.70	0.07	0.93	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-8.4	8.0	1.1e-15	-0.87	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-5.3	7.5	4.9e-14	-0.84	0.06	0.88	TRUE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-5.3	6.8	8.4e-12	-0.73	0.12	0.77	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	-5.3	6.5	6.5e-11	-0.66	0.12	0.77	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	-5.5	6.1	1.4e-09	-0.63	0.99	0.01	TRUE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	-5.5	6.9	4.2e-12	-0.70	0.10	0.88	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-5.6	5.5	3.6e-08	-0.64	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	SMAD3	0.06	0.06	lasso	2	0.06	2.5e-07	-4.9	-5.2	1.7e-07	0.11	0.93	0.01	TRUE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-5.6	6.3	2.8e-10	-0.81	0.03	0.94	TRUE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-4.5	7.1	1.6e-12	-0.79	0.21	0.78	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-5.5	6.9	4.5e-12	-0.76	0.05	0.90	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	IQCH	0.08	0.09	enet	8	0.08	2.3e-05	-5.3	5.5	4.0e-08	-0.47	0.64	0.13	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-5.5	6.9	4.9e-12	-0.72	0.04	0.65	TRUE
36	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-5.5	6.3	2.2e-10	-0.67	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-5.4	5.3	1.5e-07	-0.63	0.01	0.99	FALSE