Best TWAS P=3.86e-11 · Best GWAS P=2.38e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CFH | 0.03 | 0.03 | blup | 267 | 0.02 | 2.8e-03 | 3.0 | 5.1 | 3.1e-07 | -0.33 | 0.13 | 0.05 | FALSE |
2 | GTEx | Adipose Subcutaneous | CFH | 0.10 | 0.03 | enet | 25 | 0.03 | 2.1e-03 | -5.3 | -6.1 | 1.1e-09 | 0.60 | 0.15 | 0.83 | FALSE |
3 | GTEx | Adipose Subcutaneous | CFHR1 | 0.16 | 0.08 | lasso | 5 | 0.08 | 2.5e-07 | -5.2 | -5.2 | 2.0e-07 | 0.57 | 0.71 | 0.29 | FALSE |
4 | GTEx | Nerve Tibial | CFH | 0.16 | 0.06 | enet | 27 | 0.15 | 5.5e-11 | -5.1 | -5.1 | 3.0e-07 | 0.53 | 0.64 | 0.35 | FALSE |
5 | METSIM | Adipose | CFH | 0.03 | 0.00 | blup | 263 | 0.01 | 7.0e-03 | -5.3 | -5.9 | 2.7e-09 | 0.52 | 0.35 | 0.42 | FALSE |
6 | METSIM | Adipose | CFHR3 | 0.17 | 0.30 | bslmm | 237 | 0.31 | 7.8e-47 | 5.8 | -6.6 | 4.2e-11 | 0.71 | 0.35 | 0.65 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CFHR3 | 0.07 | 0.00 | blup | 10 | 0.05 | 1.8e-03 | 2.3 | -5.1 | 2.9e-07 | 0.43 | 0.00 | 0.12 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | CFHR3 | 0.09 | 0.03 | lasso | 2 | 0.03 | 4.9e-03 | -5.5 | -6.3 | 3.9e-10 | 0.76 | 0.00 | 0.51 | FALSE |
9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CFHR1 | 0.33 | 0.24 | lasso | 2 | 0.26 | 1.4e-12 | -6.6 | 6.1 | 1.3e-09 | -0.96 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CFHR3 | 0.14 | 0.15 | lasso | 1 | 0.14 | 3.9e-07 | -6.6 | 6.6 | 3.9e-11 | -1.00 | 0.00 | 1.00 | TRUE |
11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CFHR4 | 0.22 | 0.08 | lasso | 3 | 0.14 | 3.8e-07 | -5.4 | 6.3 | 3.4e-10 | -0.72 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CFH | 0.03 | 0.01 | enet | 8 | 0.03 | 8.5e-04 | 5.6 | -6.3 | 4.0e-10 | 0.75 | 0.02 | 0.78 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CFHR3 | 0.12 | 0.03 | enet | 4 | 0.07 | 5.0e-08 | 5.5 | -5.3 | 1.3e-07 | 0.63 | 0.09 | 0.80 | FALSE |