[Hub]/) : Traits : Lung FVC : ← →

chr1:203,692,179-206,329,620

Best TWAS P=1.01e-15 · Best GWAS P=5.01e-14 conditioned to 0.00292

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	YFS	Blood	MDM4	0.12	0.08	bslmm	636	0.12	2.0e-36	7.3	8.0	1.0e-15	0.68	0.02	0.98	TRUE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RAB7L1	0.11	0.07	blup	46	0.07	1.4e-06	-6.2	6.4	1.5e-10	-0.01	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LRRN2	0.07	0.00	bslmm	665	0.01	8.1e-03	-2.1	-6.1	9.3e-10	-0.14	0.11	0.04	TRUE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DSTYK	0.06	0.00	blup	67	0.02	1.2e-03	-3.9	5.6	2.7e-08	0.02	0.01	0.03	TRUE
25	GTEx	Skin Sun Exposed Lower leg	PIK3C2B	0.20	0.08	enet	23	0.12	6.4e-10	7.0	-7.2	5.9e-13	-0.72	0.13	0.87	FALSE
13	GTEx	Esophagus Mucosa	PIK3C2B	0.18	0.16	lasso	4	0.15	1.8e-10	7.3	7.1	1.3e-12	0.96	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	MDM4	0.02	0.03	enet	4	0.03	5.5e-04	-6.9	-7.0	2.6e-12	-0.30	0.13	0.80	FALSE
15	GTEx	Esophagus Muscularis	MDM4	0.14	0.05	lasso	4	0.05	8.6e-04	-6.7	-6.9	5.5e-12	-0.36	0.38	0.54	FALSE
28	GTEx	Testis	PIK3C2B	0.17	0.09	lasso	5	0.03	1.5e-02	-6.7	-6.8	1.4e-11	-0.29	0.37	0.45	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MDM4	0.53	0.01	lasso	7	0.05	1.5e-02	4.3	-6.7	2.2e-11	-0.30	0.03	0.08	FALSE
21	GTEx	Nerve Tibial	MDM4	0.11	0.09	lasso	1	0.07	1.6e-05	-6.7	-6.7	2.5e-11	-0.34	0.44	0.52	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	MDM4	0.05	0.06	lasso	1	0.04	1.6e-04	-6.7	-6.7	2.5e-11	-0.34	0.31	0.64	FALSE
4	GTEx	Adipose Subcutaneous	MDM4	0.09	0.02	lasso	4	0.02	4.3e-03	-6.7	-6.6	4.5e-11	-0.35	0.47	0.49	FALSE
6	GTEx	Artery Aorta	RAB7L1	0.43	0.20	lasso	8	0.29	1.9e-16	-5.7	6.3	3.4e-10	0.00	0.01	0.99	FALSE
27	GTEx	Testis	RAB7L1	0.41	0.21	lasso	13	0.26	9.2e-12	-5.2	6.3	3.6e-10	0.00	0.05	0.95	FALSE
14	GTEx	Esophagus Muscularis	RAB7L1	0.27	0.30	lasso	4	0.33	9.4e-21	-5.2	6.2	6.9e-10	0.01	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB7L1	0.12	0.12	lasso	2	0.12	3.8e-12	-5.7	6.1	1.2e-09	0.01	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB7L1	0.07	0.04	blup	46	0.07	1.2e-05	3.0	6.1	1.3e-09	0.02	0.00	0.99	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	RAB7L1	0.14	0.03	blup	46	0.07	2.5e-03	-5.2	6.0	1.5e-09	0.00	0.01	0.80	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB7L1	0.09	0.04	blup	46	0.04	1.2e-02	-5.7	6.0	1.9e-09	0.02	0.01	0.93	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB7L1	0.09	0.13	lasso	6	0.13	3.6e-14	-6.2	6.0	2.2e-09	0.02	0.00	1.00	FALSE
20	GTEx	Muscle Skeletal	RAB7L1	0.16	0.14	lasso	8	0.15	2.9e-14	-5.2	5.9	3.4e-09	0.01	0.07	0.93	FALSE
8	GTEx	Brain Caudate basal ganglia	NUCKS1	0.25	0.24	lasso	3	0.25	8.1e-08	-5.7	5.9	3.5e-09	0.00	0.01	0.98	FALSE
33	YFS	Blood	RAB7L1	0.06	0.07	lasso	6	0.06	1.1e-19	-5.7	5.8	5.3e-09	0.01	0.02	0.98	FALSE
26	GTEx	Stomach	RAB7L1	0.22	0.11	lasso	5	0.12	2.7e-06	-4.6	5.8	6.9e-09	0.01	0.05	0.93	FALSE
12	GTEx	Esophagus Mucosa	NUCKS1	0.12	0.11	enet	6	0.06	7.2e-05	-5.7	-5.8	7.3e-09	-0.01	0.01	0.99	FALSE
16	GTEx	Heart Atrial Appendage	NUCKS1	0.12	0.14	enet	4	0.08	1.7e-04	-5.7	-5.8	8.7e-09	-0.01	0.01	0.98	FALSE
22	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	-5.9	-5.7	9.0e-09	-0.01	0.01	0.88	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB7L1	0.09	0.08	lasso	2	0.07	1.1e-08	-5.7	5.7	9.4e-09	0.00	0.02	0.98	FALSE
7	GTEx	Artery Tibial	RAB7L1	0.29	0.27	lasso	9	0.31	9.7e-25	-5.7	5.7	9.6e-09	-0.01	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	RAB7L1	0.20	0.09	lasso	4	0.18	7.6e-15	-5.2	5.7	1.0e-08	-0.01	0.05	0.95	FALSE
17	GTEx	Heart Atrial Appendage	RAB7L1	0.20	0.17	enet	12	0.14	4.9e-07	-5.7	5.7	1.1e-08	0.01	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	-5.7	5.7	1.1e-08	0.02	0.04	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RAB7L1	0.07	0.03	enet	16	0.05	4.1e-07	-6.2	5.7	1.2e-08	0.00	0.00	1.00	FALSE
9	GTEx	Breast Mammary Tissue	RAB7L1	0.15	0.15	lasso	5	0.16	1.5e-08	-5.2	5.7	1.2e-08	0.00	0.05	0.95	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB7L1	0.17	0.13	lasso	2	0.11	4.4e-05	-5.7	5.7	1.3e-08	0.00	0.02	0.93	FALSE
5	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	4.9	-5.7	1.4e-08	-0.03	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NUCKS1	0.11	0.02	blup	58	0.09	1.9e-03	-4.6	-5.6	2.0e-08	-0.01	0.01	0.77	FALSE
10	GTEx	Cells Transformed fibroblasts	RAB7L1	0.30	0.23	enet	19	0.36	8.6e-28	-3.5	5.6	2.1e-08	0.03	0.03	0.97	FALSE
11	GTEx	Colon Transverse	RAB7L1	0.14	0.05	lasso	5	0.04	7.7e-03	-4.6	5.6	2.7e-08	0.01	0.02	0.87	FALSE
24	GTEx	Skin Sun Exposed Lower leg	RAB7L1	0.18	0.20	lasso	3	0.22	2.1e-18	-5.2	5.6	2.8e-08	0.01	0.06	0.93	FALSE
30	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	4.2	-5.5	4.6e-08	-0.02	0.02	0.97	FALSE
29	GTEx	Thyroid	RAB7L1	0.23	0.15	lasso	6	0.15	1.3e-11	-5.2	5.5	4.7e-08	0.00	0.07	0.93	FALSE
19	GTEx	Lung	RAB7L1	0.34	0.19	enet	53	0.31	7.5e-24	-5.3	5.3	1.1e-07	0.02	0.05	0.95	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	RAB7L1	0.17	0.14	blup	46	0.14	1.7e-08	4.2	5.3	1.5e-07	0.03	0.39	0.60	FALSE
32	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	4.5	-5.2	1.8e-07	-0.02	0.91	0.09	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	RAB7L1	0.21	0.16	enet	17	0.17	1.8e-09	-5.2	5.2	2.2e-07	0.00	0.05	0.95	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB7L1	0.09	0.08	enet	11	0.08	1.7e-09	-5.7	5.2	2.2e-07	0.04	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB7L1	0.02	0.02	enet	5	0.02	3.1e-04	-4.6	5.2	2.3e-07	0.01	0.01	0.98	FALSE
18	GTEx	Heart Left Ventricle	RAB7L1	0.33	0.09	lasso	10	0.22	4.8e-12	-5.3	5.2	2.4e-07	0.01	0.03	0.97	FALSE