[Hub]/) : Traits : Lung FVC :

chr1:203,692,179-206,329,620

Best TWAS P=1.01e-15 · Best GWAS P=5.01e-14 conditioned to 0.00292

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRRN2 0.07 0.00 bslmm 665 0.01 8.1e-03 -2.1 -6.1 9.3e-10 -0.14 0.11 0.04 TRUE
2 CommonMind Brain Pre-frontal Cortex RAB7L1 0.07 0.03 enet 16 0.05 4.1e-07 -6.2 5.7 1.2e-08 0.00 0.00 1.00 FALSE
3 GTEx Adipose Subcutaneous RAB7L1 0.20 0.09 lasso 4 0.18 7.6e-15 -5.2 5.7 1.0e-08 -0.01 0.05 0.95 FALSE
4 GTEx Adipose Subcutaneous MDM4 0.09 0.02 lasso 4 0.02 4.3e-03 -6.7 -6.6 4.5e-11 -0.35 0.47 0.49 FALSE
5 GTEx Artery Aorta NUCKS1 0.14 0.11 lasso 3 0.08 3.7e-05 4.9 -5.7 1.4e-08 -0.03 0.02 0.98 FALSE
6 GTEx Artery Aorta RAB7L1 0.43 0.20 lasso 8 0.29 1.9e-16 -5.7 6.3 3.4e-10 0.00 0.01 0.99 FALSE
7 GTEx Artery Tibial RAB7L1 0.29 0.27 lasso 9 0.31 9.7e-25 -5.7 5.7 9.6e-09 -0.01 0.01 0.99 FALSE
8 GTEx Brain Caudate basal ganglia NUCKS1 0.25 0.24 lasso 3 0.25 8.1e-08 -5.7 5.9 3.5e-09 0.00 0.01 0.98 FALSE
9 GTEx Breast Mammary Tissue RAB7L1 0.15 0.15 lasso 5 0.16 1.5e-08 -5.2 5.7 1.2e-08 0.00 0.05 0.95 FALSE
10 GTEx Cells Transformed fibroblasts RAB7L1 0.30 0.23 enet 19 0.36 8.6e-28 -3.5 5.6 2.1e-08 0.03 0.03 0.97 FALSE
11 GTEx Colon Transverse RAB7L1 0.14 0.05 lasso 5 0.04 7.7e-03 -4.6 5.6 2.7e-08 0.01 0.02 0.87 FALSE
12 GTEx Esophagus Mucosa NUCKS1 0.12 0.11 enet 6 0.06 7.2e-05 -5.7 -5.8 7.3e-09 -0.01 0.01 0.99 FALSE
13 GTEx Esophagus Mucosa PIK3C2B 0.18 0.16 lasso 4 0.15 1.8e-10 7.3 7.1 1.3e-12 0.96 0.01 0.99 FALSE
14 GTEx Esophagus Muscularis RAB7L1 0.27 0.30 lasso 4 0.33 9.4e-21 -5.2 6.2 6.9e-10 0.01 0.04 0.96 FALSE
15 GTEx Esophagus Muscularis MDM4 0.14 0.05 lasso 4 0.05 8.6e-04 -6.7 -6.9 5.5e-12 -0.36 0.38 0.54 FALSE
16 GTEx Heart Atrial Appendage NUCKS1 0.12 0.14 enet 4 0.08 1.7e-04 -5.7 -5.8 8.7e-09 -0.01 0.01 0.98 FALSE
17 GTEx Heart Atrial Appendage RAB7L1 0.20 0.17 enet 12 0.14 4.9e-07 -5.7 5.7 1.1e-08 0.01 0.01 0.99 FALSE
18 GTEx Heart Left Ventricle RAB7L1 0.33 0.09 lasso 10 0.22 4.8e-12 -5.3 5.2 2.4e-07 0.01 0.03 0.97 FALSE
19 GTEx Lung RAB7L1 0.34 0.19 enet 53 0.31 7.5e-24 -5.3 5.3 1.1e-07 0.02 0.05 0.95 FALSE
20 GTEx Muscle Skeletal RAB7L1 0.16 0.14 lasso 8 0.15 2.9e-14 -5.2 5.9 3.4e-09 0.01 0.07 0.93 FALSE
21 GTEx Nerve Tibial MDM4 0.11 0.09 lasso 1 0.07 1.6e-05 -6.7 -6.7 2.5e-11 -0.34 0.44 0.52 FALSE
22 GTEx Pancreas NUCKS1 0.16 0.00 lasso 4 0.00 4.5e-01 -5.9 -5.7 9.0e-09 -0.01 0.01 0.88 FALSE
23 GTEx Skin Not Sun Exposed Suprapubic RAB7L1 0.21 0.16 enet 17 0.17 1.8e-09 -5.2 5.2 2.2e-07 0.00 0.05 0.95 FALSE
24 GTEx Skin Sun Exposed Lower leg RAB7L1 0.18 0.20 lasso 3 0.22 2.1e-18 -5.2 5.6 2.8e-08 0.01 0.06 0.93 FALSE
25 GTEx Skin Sun Exposed Lower leg PIK3C2B 0.20 0.08 enet 23 0.12 6.4e-10 7.0 -7.2 5.9e-13 -0.72 0.13 0.87 FALSE
26 GTEx Stomach RAB7L1 0.22 0.11 lasso 5 0.12 2.7e-06 -4.6 5.8 6.9e-09 0.01 0.05 0.93 FALSE
27 GTEx Testis RAB7L1 0.41 0.21 lasso 13 0.26 9.2e-12 -5.2 6.3 3.6e-10 0.00 0.05 0.95 FALSE
28 GTEx Testis PIK3C2B 0.17 0.09 lasso 5 0.03 1.5e-02 -6.7 -6.8 1.4e-11 -0.29 0.37 0.45 FALSE
29 GTEx Thyroid RAB7L1 0.23 0.15 lasso 6 0.15 1.3e-11 -5.2 5.5 4.7e-08 0.00 0.07 0.93 FALSE
30 METSIM Adipose NUCKS1 0.05 0.02 lasso 6 0.01 4.3e-03 4.2 -5.5 4.6e-08 -0.02 0.02 0.97 FALSE
31 YFS Blood MDM4 0.12 0.08 bslmm 636 0.12 2.0e-36 7.3 8.0 1.0e-15 0.68 0.02 0.98 TRUE
32 YFS Blood NUCKS1 0.15 0.24 lasso 4 0.25 1.4e-80 4.5 -5.2 1.8e-07 -0.02 0.91 0.09 FALSE
33 YFS Blood RAB7L1 0.06 0.07 lasso 6 0.06 1.1e-19 -5.7 5.8 5.3e-09 0.01 0.02 0.98 FALSE
34 The Cancer Genome Atlas Bladder Urothelial Carcinoma RAB7L1 0.11 0.07 blup 46 0.07 1.4e-06 -6.2 6.4 1.5e-10 -0.01 0.00 1.00 TRUE
35 The Cancer Genome Atlas Breast Invasive Carcinoma RAB7L1 0.02 0.02 enet 5 0.02 3.1e-04 -4.6 5.2 2.3e-07 0.01 0.01 0.98 FALSE
36 The Cancer Genome Atlas Colon Adenocarcinoma RAB7L1 0.17 0.14 blup 46 0.14 1.7e-08 4.2 5.3 1.5e-07 0.03 0.39 0.60 FALSE
37 The Cancer Genome Atlas Esophageal Carcinoma RAB7L1 0.14 0.03 blup 46 0.07 2.5e-03 -5.2 6.0 1.5e-09 0.00 0.01 0.80 FALSE
38 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAB7L1 0.09 0.13 lasso 6 0.13 3.6e-14 -6.2 6.0 2.2e-09 0.02 0.00 1.00 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB7L1 0.09 0.08 enet 11 0.08 1.7e-09 -5.7 5.2 2.2e-07 0.04 0.02 0.98 FALSE
40 The Cancer Genome Atlas Brain Lower Grade Glioma MDM4 0.02 0.03 enet 4 0.03 5.5e-04 -6.9 -7.0 2.6e-12 -0.30 0.13 0.80 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma RAB7L1 0.09 0.08 lasso 2 0.07 1.1e-08 -5.7 5.7 9.4e-09 0.00 0.02 0.98 FALSE
42 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DSTYK 0.06 0.00 blup 67 0.02 1.2e-03 -3.9 5.6 2.7e-08 0.02 0.01 0.03 TRUE
43 The Cancer Genome Atlas Pancreatic Adenocarcinoma RAB7L1 0.09 0.04 blup 46 0.04 1.2e-02 -5.7 6.0 1.9e-09 0.02 0.01 0.93 FALSE
44 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RAB7L1 0.17 0.13 lasso 2 0.11 4.4e-05 -5.7 5.7 1.3e-08 0.00 0.02 0.93 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma RAB7L1 0.12 0.12 lasso 2 0.12 3.8e-12 -5.7 6.1 1.2e-09 0.01 0.01 0.99 FALSE
46 The Cancer Genome Atlas Skin Cutaneous Melanoma MDM4 0.53 0.01 lasso 7 0.05 1.5e-02 4.3 -6.7 2.2e-11 -0.30 0.03 0.08 FALSE
47 The Cancer Genome Atlas Stomach Adenocarcinoma RAB7L1 0.07 0.04 blup 46 0.07 1.2e-05 3.0 6.1 1.3e-09 0.02 0.00 0.99 FALSE
48 The Cancer Genome Atlas Thyroid Carcinoma MDM4 0.05 0.06 lasso 1 0.04 1.6e-04 -6.7 -6.7 2.5e-11 -0.34 0.31 0.64 FALSE
49 The Cancer Genome Atlas Thyroid Carcinoma RAB7L1 0.13 0.17 enet 15 0.21 3.6e-20 -5.7 5.7 1.1e-08 0.02 0.04 0.96 FALSE
50 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NUCKS1 0.11 0.02 blup 58 0.09 1.9e-03 -4.6 -5.6 2.0e-08 -0.01 0.01 0.77 FALSE