Hub : Genes

CFH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0300	0.0160	7.0e-03	0.026	0.018	-0.001	0.016	0.017	3.2e-04	0.0028	4.8e-01	0.0039	3.3e-03
2	GTEx	Adipose Subcutaneous	0.0970	0.0360	2.2e-06	0.034	NA	0.028	NA	0.028	8.8e-04	NA	2.1e-03	NA	2.3e-03
3	GTEx	Nerve Tibial	0.1623	0.0476	1.2e-08	0.056	NA	0.153	NA	0.147	7.7e-05	NA	5.5e-11	NA	1.4e-10
4	METSIM	Adipose	0.0251	0.0127	2.0e-03	0.004	0.011	0.009	0.009	0.009	6.9e-02	0.0070	1.2e-02	0.0130	1.2e-02
5	TCGA	Prostate Adenocarcinoma	0.0302	0.0191	1.9e-03	0.009	0.024	0.026	NA	0.019	3.9e-02	0.0014	8.5e-04	NA	3.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	2.5	1.6	-0.5	-0.2	-0.5	-1.6
Bipolar Disorder or Schizophrenia	1.7	4.3	11.6	2.4	-1.1	-1.4	-0.8	-3.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.7	-0.6	-0.8	-0.1	-1.6	-0.3
Depression (Nagel 2018)	3.3	4.9	5.9	1.6	-2.4	-2.3	-2.3	-2.4
Intelligence (Savage-Jansen 2018)	1.9	6.0	11.2	0.9	-2.4	-2.9	-2.0	-3.3
Neuroticism (Nagel 2018)	0.3	0.7	1.4	-0.1	-0.5	-0.7	-1.1	-1.2
Schizophrenia (2018)	1.6	3.4	9.6	1.8	-1.0	-1.6	-0.7	-3.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.6	0.6	0.8	0.9	0.4
Worry (Nagel 2018)	0.2	0.4	1.1	-1.0	0.6	0.3	0.4	-0.4
Alzheimer’s Disease (in mother)	0.0	0.1	0.1	0.0	-0.2	-0.2	-0.3	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	2.0	-1.4	0.9	0.3	0.6	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-1.1	0.1	0.1	-0.2	-0.3
Crohns Disease (2017)	0.6	1.4	3.3	1.0	-0.2	1.8	1.2	1.1
Irritable Bowel Disease (IBD)	0.5	1.3	2.9	0.6	0.7	1.2	1.1	1.7
Ulcerative Colitis (UC)	0.3	0.6	1.8	0.3	0.9	0.2	0.6	1.3
Major Depression (MDD)	0.4	0.4	0.9	0.8	-0.9	0.3	-0.6	-0.5
Reaction Time	0.6	1.2	2.1	1.2	0.1	1.2	1.0	1.4
Verbal and Numeric Reasoning (VNR)	1.2	3.0	8.2	-0.8	-0.9	-2.0	-1.1	-2.9
Breast Cancer	0.3	0.7	1.5	1.2	-0.5	-0.4	-0.6	-1.1
Ovarian Cancer	1.2	1.5	3.1	1.4	-0.3	-1.8	-1.4	-0.6
Prostate Cancer	0.5	0.8	2.1	0.2	-0.9	-0.7	-0.6	-1.4
Age at First Birth	0.6	0.8	1.7	1.3	-0.7	-1.3	-0.6	0.0
Bipolar Disorder (2011)	1.4	1.4	2.8	1.7	-1.4	-0.3	-0.8	-1.2
Body Mass Index (BMI) (2010)	1.6	2.3	4.8	-1.4	2.2	0.6	0.5	2.0
Coronary Artery Disease (CAD)	1.0	1.2	3.3	-0.8	0.7	0.7	1.8	1.2
Crohns Disease (2012)	1.3	2.0	4.5	2.1	-2.0	-0.2	-0.6	-1.2
Mean Putamen Volume	0.9	1.0	2.7	-0.8	-0.2	-1.2	-1.6	-0.2
Fasting Glucose	1.0	1.2	1.6	-0.6	1.2	1.1	1.3	1.2
HbA1C	4.1	4.5	9.6	2.0	-3.1	-1.0	-2.4	-1.5
HDL Cholesterol	1.5	2.5	4.1	-1.9	1.9	1.1	2.0	0.4
LDL Cholesterol	0.2	0.3	0.8	0.6	0.3	0.9	0.5	-0.2
Lupus	0.2	0.3	0.9	-0.2	0.9	-0.7	0.2	-0.4
Neuroticism (2016)	1.9	2.7	5.5	1.1	-0.9	-2.0	-2.4	-1.4
Primary Biliary Cirrhosis	1.3	1.9	2.5	1.0	-1.5	-1.3	-1.4	-1.6
Rheumatoid Arthritis	1.1	1.6	2.4	-1.5	1.6	0.9	1.2	1.0
Schizophrenia (2014)	1.5	3.3	6.6	2.6	-1.6	-1.3	-0.7	-2.4
Triglycerides	0.2	0.3	1.1	-0.3	0.1	0.2	-0.4	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.5	0.4	-0.6	0.8	0.3
Ulcerative Colitis	0.2	0.4	1.1	0.1	1.0	-0.6	0.5	-0.3
Blood Eosinophil Count	0.9	6.6	19.7	-0.8	1.2	2.8	1.8	4.4
Blood Platelet Count	0.1	1.2	3.4	0.8	0.6	-1.9	-1.1	-0.8
Blood Red Count	0.2	1.8	2.8	-1.2	1.4	1.7	0.4	1.7
Blood White Count	0.2	1.8	5.3	0.6	-1.2	-1.1	-2.3	-0.6
Heel T-Score	0.0	0.2	0.6	-0.4	-0.3	0.3	0.8	0.2
BMI	0.4	2.5	4.3	-2.1	1.8	1.3	-0.1	1.7
Height	0.0	0.7	1.1	0.4	-1.1	-0.9	-0.9	-0.7
Waist Hip Ratio (WHR)	5.3	23.7	27.8	-4.4	5.3	4.5	5.3	4.8
Systolic Blood Pressure	2.8	14.3	28.0	-2.3	3.0	5.3	3.9	3.7
Smoking Status	0.2	0.6	1.0	-1.0	-0.8	-0.0	0.5	-1.0
Allergy or Eczema	4.5	11.9	14.6	-3.4	3.1	3.6	3.4	3.8
Cardiovascular Disease	0.5	1.7	2.2	-1.1	1.4	1.3	1.5	1.1
Hypothyroidism (self reported)	0.1	0.3	1.1	0.0	1.0	-0.4	0.7	0.1
Respiratory disease	0.6	1.4	4.1	-0.2	0.2	1.3	1.0	2.0
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.4	-1.0	1.7	1.7	1.2	2.3
Lung FEV1/FVC ratio	3.5	18.0	28.5	-2.5	5.3	4.0	4.2	4.6
Lung FVC	6.4	32.8	39.1	5.1	-6.1	-5.1	-5.9	-6.3
Neuroticism	0.6	1.3	2.3	0.3	-1.2	-1.1	-1.3	-1.5
Chronotype (morning person)	1.8	4.1	14.6	-3.8	2.0	-0.4	0.9	1.1
Hair Pigment	0.1	1.8	3.0	1.3	-1.0	-1.7	-1.5	-1.1
Tanning	0.6	7.5	11.0	-3.2	2.8	2.1	3.3	2.0
Hand grip strength (left)	0.3	0.8	1.5	0.8	0.4	-0.7	-1.2	-0.9
Number of treatments/medications taken	1.9	3.4	9.1	0.7	0.4	2.5	0.9	3.0
Average weekly spirits intake	1.8	2.2	3.3	1.8	0.1	1.8	1.2	1.7
Sensitivity / hurt feelings	0.5	0.8	1.8	-1.0	0.4	1.0	1.4	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.7	3.5	0.9	-1.8	-1.9	-1.8	-1.7
Hearing difficulty/problems: Yes	2.6	4.0	8.1	-2.8	2.3	1.2	1.6	1.7
Relative age of first facial hair	0.9	1.9	5.3	1.0	-0.2	-1.6	-0.7	-2.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	-0.4	-0.0	0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.5	-0.2	0.8	1.1	-0.3
Ever had hysterectomy (womb removed)	0.8	0.9	1.4	-1.2	0.2	1.1	1.1	-0.7
Systolic blood pressure, automated reading	2.6	7.4	19.6	-1.6	1.1	4.4	2.5	2.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	-0.3	0.1	-0.7	-0.6	1.2
Angina	0.2	0.3	0.8	-0.3	0.9	0.3	0.6	0.4
Medication for hormone replacement therapy	1.1	1.3	3.0	0.4	-0.2	1.7	1.5	1.0
Vitamin and mineral supplements	0.7	1.0	1.9	-0.3	0.3	-1.4	-1.4	-1.0
Supplements: Zinc	0.4	0.4	1.0	1.0	-0.6	0.2	-0.7	-0.5
Medication: Co-codamol	0.4	0.5	1.9	0.5	0.5	0.2	0.2	1.4
Medication: Metformin	1.9	2.7	4.4	-1.2	1.8	1.5	1.4	2.1
Diabetes (father)	0.3	0.4	0.8	0.9	-0.1	0.6	-0.2	0.9
Diabetes (mother)	0.3	0.4	1.4	-0.2	0.5	0.7	0.1	1.2
Severe depression (siblings)	2.0	2.2	5.1	-1.2	1.5	1.2	2.2	0.7
Pack years adult smoking proportion	0.2	0.3	1.2	1.1	-0.6	0.1	-0.0	0.2
Impedance of leg (right)	0.1	0.5	1.0	-0.4	1.0	0.3	1.0	-0.3
Leg fat-free mass (left)	0.1	0.3	0.8	-0.9	0.5	-0.3	-0.4	0.6
Trunk fat percentage	0.8	3.0	5.4	-2.1	2.3	1.3	0.7	1.7
Hand grip strength (right)	0.2	0.5	1.1	0.7	0.6	-0.5	-1.1	-0.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.1	0.2	0.6	0.5	-0.5
Current tobacco smoking	0.4	0.7	1.1	0.1	-1.0	-0.5	-1.1	-1.0
Average weekly fortified wine intake	0.3	0.3	0.8	0.5	0.9	-0.1	0.6	0.4
Maternal smoking around birth	1.9	2.7	4.4	-1.7	2.1	1.2	2.1	0.6
Fed-up feelings	0.5	0.9	3.5	-0.0	-0.9	-0.3	-1.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.6	1.1	-1.5	-1.2	-1.3	-1.6
Relative age voice broke	0.3	0.5	1.1	-0.4	1.0	-0.4	-0.0	-1.0
Taking other prescription medications	1.6	2.4	4.9	-0.2	0.7	1.8	1.9	2.2
Age when periods started (menarche)	0.4	1.1	3.5	0.2	0.1	-1.9	-1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.2	-1.3	0.3	1.1	1.8	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	-0.0	-0.3	0.0	-0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.6	-0.4	-0.9	-0.5	-0.0
Qualifications: CSEs or equivalent	0.3	0.3	0.7	-0.1	0.9	0.6	0.3	0.8
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.9	-0.2	-0.8	0.5	-0.8
High blood pressure	0.4	1.2	2.1	-0.5	1.4	1.0	1.2	1.2
Hayfever, allergic rhinitis or eczema	5.7	12.4	13.4	-3.5	3.5	3.6	3.7	3.4
Multivitamins +/- minerals	1.3	1.6	3.3	0.2	0.2	1.7	1.3	1.8
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.6	0.7	0.5	1.2	0.3
Supplements: Glucosamine	0.6	0.8	2.1	1.4	-1.0	0.9	-0.2	0.6
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	3.7	0.4	-1.8	-1.4	-1.1	-1.9
Medication: Atenolol	0.2	0.2	0.5	-0.0	0.7	0.7	0.3	-0.0
Medication: Levothyroxine sodium	0.3	0.6	1.8	-1.4	0.6	-0.0	0.7	0.2
Sitting height	0.1	0.6	1.5	-1.0	0.3	0.4	1.2	-0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	0.7	0.0	-0.9	-0.6	-1.5
High blood pressure (mother)	0.4	0.5	1.0	0.7	-0.3	-0.3	-1.0	1.0
Body mass index (BMI)	0.6	2.4	3.9	-2.0	1.7	1.4	0.5	1.8
Impedance of leg (left)	0.2	1.1	2.1	-1.1	1.4	0.8	1.4	0.1
Leg predicted mass (left)	0.1	0.3	0.7	-0.8	0.4	-0.3	-0.4	0.6
Trunk fat mass	0.7	3.1	5.5	-2.3	2.3	1.1	0.7	1.7
Waist circumference	1.8	6.5	8.5	-2.8	2.8	2.2	1.8	2.9
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	-0.3	0.5	0.2	-0.5
Past tobacco smoking	1.0	1.9	3.6	-0.4	1.9	1.2	1.2	1.7
Alcohol usually taken with meals	0.5	0.9	2.0	1.4	-0.4	-1.0	-0.8	0.8
Nervous feelings	1.6	3.0	5.5	-2.1	1.5	1.5	2.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.5	-0.2	-0.7	-0.0	-0.2
Hearing difficulty/problems with background noise	0.2	0.4	1.6	-1.2	0.1	0.2	-0.0	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-0.7	1.0	0.3	0.5	1.0
Had menopause	2.2	2.8	7.2	0.9	-2.7	-1.2	-1.4	-1.5
Had other major operations	0.3	0.4	1.3	-0.6	-1.1	-0.3	-0.1	0.3
Forced vital capacity (FVC)	2.1	8.2	13.0	2.2	-3.1	-2.6	-2.7	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.2	0.4	0.3	0.4	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.0	0.2	0.3	0.4	-0.7
Qualifications: None of the above	2.0	4.3	8.7	-3.0	2.2	1.4	1.5	1.9
Financial difficulties in last 2 years	1.9	2.5	4.1	2.0	-1.7	-1.5	-1.6	-0.9
Mouth/teeth dental problems	0.4	0.6	1.3	0.7	-0.4	0.3	-0.9	1.1
Heart attack	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3	0.1
Allergy	4.9	11.3	13.6	2.8	-3.1	-3.6	-3.6	-3.7
Pain all over the body in last month	0.5	0.5	1.7	0.1	-0.0	-0.8	-0.4	-1.3
Diabetes (self-reported)	0.7	1.1	2.6	-0.6	1.2	0.9	0.6	1.6
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	7.6	-2.1	2.2	2.8	2.4	1.5
Medication: Ramipril	0.3	0.4	1.1	0.4	1.0	-0.2	-0.2	0.8
Medication: Simvastatin	0.1	0.2	0.5	0.1	0.7	0.6	0.1	0.4
Fluid intelligence score	0.6	1.3	3.6	0.5	-0.7	-1.4	-0.3	-1.9
Illnesses of siblings	2.6	3.7	5.3	1.8	-2.3	-1.6	-1.8	-2.1
Neuroticism score	0.3	0.5	1.8	-1.4	-0.1	-0.5	-0.2	-0.8
Weight	0.4	1.8	3.4	-1.8	1.4	0.9	0.5	1.5
Impedance of arm (right)	0.2	0.8	1.8	1.0	-0.3	-0.8	-0.6	-1.4
Arm fat percentage (right)	0.6	2.4	4.1	-2.0	2.0	1.4	0.4	1.5
Trunk fat-free mass	0.1	0.7	2.0	-1.4	0.8	0.1	0.4	0.8
Hip circumference	0.1	0.3	0.6	-0.8	0.5	-0.1	-0.5	0.6
Time employed in main current job	1.6	1.9	3.4	1.1	1.2	1.8	0.5	1.7
Alcohol intake versus 10 years previously	7.0	10.5	13.3	-3.6	3.4	2.4	3.6	2.9
Father’s age at death	1.0	1.4	3.3	1.8	-0.9	0.2	-0.3	-1.6
Worrier / anxious feelings	0.6	1.0	2.8	-1.7	1.5	0.2	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.1	-0.3	-1.4	-1.8	-0.4	-1.3
Falls in the last year	0.3	0.5	1.1	0.7	-1.1	-0.5	-0.4	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.3	0.0	0.8	0.3	0.7
Number of live births	0.5	0.7	2.5	0.1	-0.2	-1.6	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.2	1.5	-1.2	-1.5	-1.3	-2.0
Pulse rate	0.3	0.6	1.9	-0.0	0.7	0.3	-0.4	1.4
Happiness	1.9	2.3	4.5	0.5	-1.6	-1.4	-2.1	-1.5
Noisy workplace	0.8	0.9	1.8	0.1	1.3	0.9	0.9	1.1
Qualifications: A levels/AS levels or equivalent	1.2	2.6	6.1	2.5	-1.2	-1.7	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.6	0.3	0.1	-0.3	0.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	-0.7	0.0	0.3	0.4	0.0
Asthma	0.7	1.4	3.8	-0.3	0.4	1.3	1.1	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	-0.4	0.4	-0.5	-0.7	-0.5
Medication: Cholesterol lowering	0.6	0.9	2.1	-0.5	1.5	0.7	1.2	0.7
Depression (self-reported)	1.3	1.6	4.6	1.6	-2.1	0.2	-0.8	-0.6
Medication: Lansoprazole	0.8	0.9	1.8	0.8	-0.7	-1.2	-1.3	-0.1
Prospective memory result	1.5	1.9	3.1	0.6	-1.5	-1.8	-1.7	-0.9
Lung cancer (father)	0.8	1.0	1.9	-0.3	0.7	1.4	1.2	0.9
Illnesses of mother	0.7	0.9	2.4	-1.6	0.9	-0.2	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.7	0.8	-1.1	-1.7	-1.0	-2.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.3	0.7	0.1	0.6	0.0
Impedance of arm (left)	0.1	0.4	1.0	0.7	-0.0	-0.6	-0.4	-1.0
Arm fat mass (right)	0.6	2.3	3.9	-2.0	1.8	1.2	0.5	1.5
Trunk predicted mass	0.1	0.7	2.1	-1.4	0.8	0.0	0.3	0.8
Standing height	0.0	0.2	0.5	-0.2	-0.2	-0.7	0.1	-0.5
Length of working week for main job	0.2	0.2	0.5	-0.7	0.5	0.0	0.5	0.1
Exposure to tobacco smoke at home	0.3	0.3	0.7	0.1	0.6	0.0	0.6	0.8
Breastfed as a baby	3.0	3.7	5.0	2.1	-1.7	-2.2	-1.6	-2.0
Tense / ‘highly strung’	0.4	0.7	1.2	-0.7	0.9	0.5	1.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-0.2	-0.5	-0.6	-1.0	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	0.4	1.0	1.3	0.9	1.5
Birth weight of first child	0.9	1.7	3.1	-1.3	1.8	-1.5	1.0	-0.7
Peak expiratory flow (PEF)	0.2	0.5	0.7	0.9	0.7	0.4	0.4	0.9
Pulse wave reflection index	0.4	0.5	1.7	0.1	-0.1	-0.6	0.4	-1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.5	-0.7	-0.0	-1.6	-1.1	-0.8
Loud music exposure frequency	0.5	0.5	1.6	0.2	0.5	-0.9	0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.0	1.7	-1.1	-0.9	-1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	7.6	0.0	-0.8	-1.6	-0.9	-2.8
Blood clot in the leg (DVT)	2.0	2.5	5.4	-1.2	1.3	1.6	1.3	2.3
Medication: Paracetamol	0.3	0.5	1.4	-1.2	0.1	1.0	0.1	-0.1
Headache pain in last month	0.4	0.6	1.3	0.1	-0.5	-0.9	-1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.3	-0.9	-0.2	-0.8	-0.1
Glaucoma (self-reported)	0.3	0.3	0.8	0.6	0.4	-0.9	-0.4	0.1
Gout (self-reported)	2.2	3.1	5.6	-0.7	1.9	2.1	2.4	1.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	0.3	-0.0	-0.0	0.5	0.2
Medication: Amlodipine	0.6	0.8	1.8	1.3	0.6	-0.4	-1.2	0.5
Medication: Ventolin 100micrograms inhaler	2.6	3.4	4.9	-1.2	1.8	2.0	2.2	1.9
Birth weight	0.3	0.6	1.9	-0.3	1.0	-0.5	-0.2	1.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.2
High blood pressure (siblings)	0.1	0.1	0.3	0.6	0.2	0.1	0.1	0.4
Forced vital capacity (FVC), Best measure	2.3	8.3	15.8	1.6	-3.0	-2.8	-2.6	-4.0
Body fat percentage	0.7	3.0	5.0	-2.1	2.2	1.4	0.6	1.6
Leg fat percentage (right)	0.5	1.9	3.0	-1.7	1.7	1.4	0.7	1.2
Arm fat-free mass (right)	0.3	1.4	2.9	-1.7	1.0	0.6	0.7	1.4
Exposure to tobacco smoke outside home	1.9	2.6	4.9	0.3	-1.6	-2.2	-1.6	-1.6
Comparative body size at age 10	0.4	1.2	2.1	1.1	-0.6	1.4	-0.7	1.4
Number of full brothers	0.4	0.5	1.0	-1.0	0.6	-0.9	0.4	-0.6
Worry too long after embarrassment	0.1	0.2	0.5	-0.7	-0.1	-0.1	0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	0.5	-0.9	-0.9	-0.9	-1.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	1.2	-0.2	0.2	-0.1	1.1
Number of children fathered	2.3	2.6	4.9	-0.8	2.2	1.1	2.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.9	1.7	-0.3	0.2	-0.4	0.2
Age at first live birth	0.0	0.1	0.2	0.4	-0.1	-0.4	-0.1	-0.1
Pulse wave peak to peak time	0.3	0.4	1.0	0.4	-1.0	-0.4	-0.7	-0.3
Health satisfaction	0.1	0.1	0.3	0.4	-0.1	-0.1	-0.3	0.5
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.4	-0.5	-0.7	-0.6	-0.3
Qualifications: College or University degree	1.0	3.3	5.0	1.5	-1.7	-2.2	-1.5	-2.0
Eye problems/disorders: None of the above	0.6	0.7	2.1	-0.3	-0.1	1.5	0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	0.8	0.4	1.1	0.3	1.0
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.1	-0.2	-0.9	-0.2	-0.9
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.2
Neck or shoulder pain in last month	1.5	2.2	4.1	-1.2	1.4	1.5	2.0	1.0
Medication: Blood pressure	0.3	0.5	1.7	-0.3	1.3	-0.1	0.5	0.6
Angina (self-reported)	0.1	0.1	0.3	0.0	0.6	-0.1	0.3	-0.1
Migraine (self-reported)	0.3	0.4	0.8	0.2	-0.9	0.2	0.3	-0.9
Medication: Ibuprofen	0.2	0.2	0.5	-0.7	0.7	0.1	-0.4	0.0
Medication: Allopurinol	2.9	3.9	7.8	-0.7	2.4	2.1	2.8	0.8
Medication: Omeprazole	0.8	0.9	1.7	-0.1	1.3	0.1	1.1	1.3
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.7	-0.7	-0.5	-0.3	-0.4
Mean time to correctly identify matches	0.6	1.1	2.0	1.4	-0.6	0.9	0.5	1.4
Heart disease (mother)	0.3	0.4	0.8	-0.9	0.6	0.5	0.8	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.3	-0.4	1.8	1.4	1.5	1.8
Whole body fat mass	0.6	2.5	4.4	-2.1	2.0	1.1	0.5	1.6
Leg fat mass (right)	0.5	1.9	3.1	-1.8	1.7	1.1	0.6	1.4
Arm predicted mass (right)	0.2	1.3	3.5	-1.9	0.9	0.4	0.7	1.2
Pulse rate, automated reading	0.9	2.8	5.7	-1.1	2.4	1.1	1.2	2.1
Alcohol intake frequency.	0.1	0.2	0.9	-0.0	0.3	-0.9	-0.3	0.2
Comparative height size at age 10	0.2	1.1	2.4	0.8	-1.5	-1.2	-1.0	-0.5
Number of full sisters	2.3	2.7	3.8	-1.1	1.9	1.8	1.8	1.4
Suffer from ‘nerves’	0.2	0.3	1.0	-0.2	-1.0	-0.3	0.3	-0.4
Overall health rating	2.0	4.4	5.7	-2.2	2.0	1.2	2.4	2.4
Chest pain or discomfort	1.2	1.7	5.8	0.2	-1.5	-0.6	-0.0	-2.4
Had major operations	2.4	2.8	5.6	1.9	-1.0	-1.8	-1.0	-2.4
Age at last live birth	0.8	1.1	2.1	-1.4	1.2	0.3	1.4	-0.4
Family relationship satisfaction	1.4	1.7	3.1	1.0	-1.4	-1.2	-1.8	-0.8
Leg pain on walking	0.3	0.4	1.0	-0.5	-0.1	-0.9	-1.0	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	4.0	-1.7	2.0	-0.2	0.7	1.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	1.0	-0.9	-0.8	-0.8	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	-0.8	0.7	0.8	1.0	0.4
Medication: Aspirin	0.5	0.7	1.3	1.1	-1.1	-0.1	-1.0	0.2
Supplements: Vitamin C	1.5	1.7	5.3	2.3	-1.3	0.1	-0.8	-1.0
Knee pain experienced in last month	0.3	0.5	2.0	-0.4	0.6	0.3	0.2	1.4
Hypertension (Self-reported)	0.3	1.0	1.7	-0.3	1.3	1.0	0.9	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	0.6	-0.2	-0.2	-0.3	0.5
Illnesses of father: Heart disease	0.3	0.5	1.1	-0.4	1.1	-0.4	0.5	0.8
Illnesses of siblings: Diabetes	4.4	5.4	9.1	-2.2	2.8	1.8	1.5	3.0
Smoking status: Previous	0.5	0.8	1.6	-0.1	-1.2	-0.8	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.1	-0.8	1.4	0.4	1.3	1.2
Whole body fat-free mass	0.1	0.6	1.7	-1.3	0.7	0.1	0.1	1.0
Leg fat-free mass (right)	0.1	0.4	1.0	-1.0	0.5	-0.0	-0.2	0.9
Arm fat percentage (left)	0.6	2.4	4.0	-2.0	2.0	1.3	0.3	1.5
Average weekly red wine intake	0.9	1.4	3.4	0.4	-1.2	-1.3	-0.4	-1.8
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.1	-0.9	0.4	1.1	0.7	-0.1
Mood swings	0.2	0.4	1.0	-0.5	-0.7	0.1	-1.0	-0.7
Loneliness, isolation	1.7	2.3	4.4	-0.4	-1.2	-1.8	-2.1	-1.5
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.4	1.1	-0.1	0.9	0.3
Ever had bowel cancer screening	1.1	1.2	3.0	-0.0	-0.7	-1.3	-1.0	-1.7
Diabetes diagnosed by doctor	0.7	1.1	3.2	-0.5	1.1	0.9	0.4	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.9	-1.4	0.8	0.4	0.1	-0.7
Friendships satisfaction	0.6	0.8	1.5	1.0	-0.6	-0.8	-1.2	-0.5
Qualifications: nursing, teaching	10.4	16.1	20.0	3.8	-4.5	-4.0	-4.2	-3.6
Commuting to job workplace: Walk	0.7	0.8	2.4	0.3	-0.5	-0.5	-1.0	-1.6
Eye problems/disorders: Cataract	0.3	0.3	1.1	1.1	-0.3	-0.3	-0.6	0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.5	-1.4	1.9	-0.1	1.3	-0.1
Medication for cholesterol	1.0	1.6	4.7	0.2	-0.3	-2.2	-1.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.8	0.2	0.1	0.1	0.6
Back pain experienced in last month	1.7	2.5	6.9	-2.6	1.6	0.2	1.8	0.0
Mineral and other dietary supplements	0.5	0.6	1.7	-0.3	0.4	-1.3	-0.5	-1.0
Breast cancer (self-reported)	0.9	1.0	2.3	-0.3	-0.6	1.5	0.5	1.5
Asthma (self-reported)	0.5	1.1	3.3	0.2	0.1	1.1	0.9	1.8
Osteoporosis (self-reported)	0.3	0.4	1.1	0.2	0.1	-1.1	-0.5	-0.6
Osteoarthritis (self-reported)	0.8	1.1	2.8	-0.7	-0.2	1.3	0.7	1.7
Medication: Aspirin	0.4	0.5	0.9	0.9	-0.7	-0.0	-0.7	0.8
Medication: Gliclazide	0.3	0.3	1.1	0.2	1.0	-0.4	-0.4	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	0.2	-0.5	0.9	1.3	0.4
Smoking status: Current	0.6	0.9	1.5	0.5	-1.2	-0.7	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.1	4.5	1.0	-1.1	-2.1	-2.1	-2.0
Whole body water mass	0.1	0.6	1.5	-1.2	0.7	0.1	0.2	1.0
Leg predicted mass (right)	0.1	0.4	1.0	-1.0	0.5	-0.1	-0.2	0.8
Arm fat mass (left)	0.6	2.4	4.1	-2.0	1.8	1.3	0.6	1.6
Number of self-reported non-cancer illnesses	0.7	1.3	3.3	-0.1	0.5	1.5	0.8	1.8
Average weekly champagne plus white wine intake	1.4	1.9	3.7	1.9	-1.0	-1.3	-1.6	-0.7
Miserableness	0.3	0.5	2.1	-1.4	0.6	0.3	-0.4	0.1
Guilty feelings	0.9	1.3	1.9	1.1	-1.4	-1.3	-1.0	-0.9
Wears glasses or contact lenses	0.8	0.9	2.0	-1.3	1.4	0.2	0.9	0.5
Ever taken oral contraceptive pill	2.8	3.1	4.9	-2.2	1.8	1.6	1.7	1.4
Hearing aid user	0.2	0.2	1.0	1.0	-0.0	-0.1	-0.2	-0.0
Mother’s age at death	1.7	2.1	3.2	0.8	-0.9	-1.8	-1.7	-1.7
Financial situation satisfaction	0.8	1.0	2.7	-0.5	-0.9	-1.6	-0.9	-0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.8	1.1	-1.7	1.1	0.2	0.5
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.4	0.7	0.6	0.3	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.1	1.3	-0.2	-1.4	-1.4	-0.3
Medication: Blood pressure	0.9	1.7	3.8	-0.7	1.3	1.9	0.9	1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.5	-0.6	0.8	0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	0.8	-0.5	1.0	0.2	1.5
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.2	-0.3	-0.0	0.2	-0.3
Medication: Bendroflumethiazide	0.4	0.7	2.2	-0.1	0.3	1.5	0.9	0.6
Medication: Paracetamol	0.3	0.5	2.0	-0.7	-0.1	1.4	0.2	0.3
Medication: Lisinopril	0.8	1.0	2.3	-1.2	0.6	1.5	0.7	0.4
Medication: Atorvastatin	0.4	0.5	1.1	-1.1	1.0	0.2	0.3	0.5
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.2	0.1	-0.2	-0.8	1.0
Alcohol drinker status: Never	2.4	2.9	5.0	1.6	-1.4	-1.7	-1.5	-2.2
Ever smoked	2.2	3.8	6.7	0.9	-2.2	-1.8	-1.8	-2.6
Basal metabolic rate	0.2	1.1	2.6	-1.6	1.1	0.3	0.3	1.1
Leg fat percentage (left)	0.9	3.2	5.1	-2.3	2.0	1.7	1.1	1.6
Arm fat-free mass (left)	0.2	1.1	2.5	-1.6	0.7	0.7	0.7	1.2
Number of operations (self-reported)	0.6	0.9	1.3	1.2	-1.1	-0.4	-0.5	-1.1
Average weekly beer plus cider intake	3.9	5.6	11.4	-3.4	2.5	1.6	2.3	1.6
Irritability	1.2	2.1	4.0	-1.5	0.5	-1.9	-0.7	-2.0
Risk taking	0.3	0.4	0.9	0.6	-0.1	-0.7	0.4	-0.9
Ever had prostate specific antigen (PSA) test	5.6	6.5	11.3	-1.8	2.8	2.1	3.4	2.3
Fractured/broken bones in last 5 years	0.6	0.8	2.9	0.7	-0.6	-1.7	-0.5	-0.0
Age started oral contraceptive pill	0.2	0.3	0.5	0.7	-0.7	-0.2	-0.7	-0.3
Diastolic blood pressure, automated reading	2.0	6.1	14.1	-1.4	1.9	3.8	1.8	2.8
Ever depressed for a whole week	0.4	0.5	1.3	-0.3	-0.1	-1.0	0.1	-1.1
Unable to work because of sickness or disability	0.4	0.5	0.9	0.5	-0.9	-0.8	-0.6	-0.8
Commuting to job workplace: Cycle	0.7	0.8	2.1	1.4	-0.9	-0.5	-0.6	-0.7
Myopia	0.1	0.1	0.2	-0.2	0.3	-0.5	0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.2	0.7	-1.6	-1.6	-1.4	-1.8
Cholesterol lowering medication	0.4	0.6	1.4	0.1	-0.9	-0.5	-1.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.0	-0.4	1.6	0.0	1.4	1.7
Pain experienced in last month	1.0	1.7	2.3	1.5	-1.4	-0.7	-1.5	-1.1
Supplements: Calcium	0.4	0.4	1.3	-0.7	0.3	1.1	0.2	0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	-0.5	0.6	0.0	0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.2	0.2	0.1	-0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.7	-1.1	1.3	1.6	1.2	2.2
Heart disease (siblings)	0.9	1.1	2.9	-1.7	0.8	0.5	1.1	0.7
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.2	0.5	-0.1	0.1	0.3
Pack years of smoking	0.3	0.5	1.4	1.2	-1.0	0.2	-0.0	0.2
Impedance of whole body	0.0	0.1	0.5	0.1	0.4	-0.1	0.2	-0.7
Leg fat mass (left)	0.7	2.6	4.4	-2.1	1.8	1.3	0.8	1.7
Arm predicted mass (left)	0.2	1.0	2.8	-1.7	0.8	0.6	0.6	1.0