Best TWAS P=2.35e-08 · Best GWAS P=1.28e-15 conditioned to 5.11e-18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAN2C1 | 0.13 | 0.17 | lasso | 5 | 0.18 | 2.5e-21 | 4.4 | 5.3 | 1.4e-07 | 0.10 | 0.04 | 0.91 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | SNUPN | 0.11 | 0.12 | lasso | 5 | 0.10 | 7.7e-04 | -4.5 | 5.2 | 2.6e-07 | 0.06 | 0.02 | 0.60 | FALSE |
| 3 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | 4.5 | 5.5 | 3.4e-08 | 0.10 | 0.03 | 0.82 | FALSE |
| 4 | GTEx | Thyroid | SNUPN | 0.15 | 0.10 | lasso | 7 | 0.16 | 6.2e-12 | -4.6 | 5.5 | 3.7e-08 | 0.10 | 0.02 | 0.96 | FALSE |
| 5 | METSIM | Adipose | SNUPN | 0.03 | 0.01 | bslmm | 218 | 0.02 | 7.2e-04 | -4.6 | 5.3 | 1.2e-07 | 0.05 | 0.02 | 0.75 | FALSE |
| 6 | YFS | Blood | ARID3B | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-13 | -4.5 | 5.6 | 2.3e-08 | 0.03 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNUPN | 0.04 | 0.02 | lasso | 3 | 0.03 | 3.3e-06 | -4.5 | 5.4 | 6.5e-08 | 0.07 | 0.00 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MAN2C1 | 0.11 | 0.05 | lasso | 5 | 0.09 | 1.2e-05 | -4.5 | 5.2 | 1.6e-07 | 0.10 | 0.00 | 0.65 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SNUPN | 0.11 | 0.06 | blup | 38 | 0.06 | 3.9e-04 | 4.4 | 5.2 | 1.8e-07 | 0.12 | 0.01 | 0.66 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAN2C1 | 0.08 | 0.06 | blup | 14 | 0.09 | 2.0e-10 | 4.3 | 5.3 | 1.3e-07 | 0.10 | 0.01 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAN2C1 | 0.07 | 0.04 | blup | 15 | 0.05 | 6.6e-06 | -4.5 | 5.4 | 6.7e-08 | 0.07 | 0.00 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNUPN | 0.13 | 0.09 | blup | 38 | 0.12 | 6.0e-13 | -4.5 | 5.2 | 2.4e-07 | 0.10 | 0.00 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | MAN2C1 | 0.09 | 0.05 | blup | 13 | 0.06 | 3.1e-06 | -4.5 | 5.3 | 1.5e-07 | 0.07 | 0.00 | 0.90 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | SNUPN | 0.19 | 0.12 | enet | 11 | 0.20 | 1.1e-19 | -4.5 | 5.5 | 3.2e-08 | 0.09 | 0.00 | 0.97 | TRUE |