Best TWAS P=1.14e-10 · Best GWAS P=5.27e-12 conditioned to 0.0123
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYKK | 0.08 | 0.01 | lasso | 2 | 0.01 | 3.0e-02 | 3.5 | 5.3 | 9.1e-08 | -0.80 | 0.04 | 0.77 | FALSE |
| 2 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | -6.4 | -6.4 | 1.5e-10 | 0.94 | 0.02 | 0.93 | FALSE |
| 3 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | -6.8 | 5.2 | 1.9e-07 | -0.76 | 0.01 | 0.99 | FALSE |
| 4 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | -6.9 | -6.0 | 2.1e-09 | 0.88 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | -6.4 | 6.4 | 1.1e-10 | -0.90 | 0.00 | 0.99 | TRUE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | -6.4 | 6.3 | 3.9e-10 | -0.93 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNA5 | 0.02 | 0.01 | blup | 50 | 0.02 | 2.6e-03 | 3.9 | 5.7 | 1.3e-08 | -0.83 | 0.01 | 0.78 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMA4 | 0.03 | 0.02 | blup | 40 | 0.02 | 3.1e-03 | 4.1 | -5.7 | 1.3e-08 | 0.81 | 0.02 | 0.64 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | -6.4 | 5.5 | 3.4e-08 | -0.86 | 0.00 | 0.98 | FALSE |