Hub : Genes

ARID3B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0230	9.4e-04	0.034	0.029	0.007	0.030	0.022	5.1e-05	1.7e-04	4.5e-02	1.4e-04	9.2e-04
2	GTEx	Artery Aorta	0.1460	0.0640	7.0e-03	-0.004	NA	0.029	NA	0.014	6.3e-01	NA	9.6e-03	NA	5.3e-02
3	GTEx	Artery Tibial	0.1107	0.0407	1.6e-03	0.048	NA	0.015	NA	0.033	1.2e-04	NA	2.3e-02	NA	1.2e-03
4	GTEx	Brain Frontal Cortex BA9	0.2042	0.0956	7.8e-03	0.134	NA	0.090	NA	0.135	2.1e-04	NA	2.2e-03	NA	2.0e-04
5	GTEx	Testis	0.1370	0.0530	2.9e-03	0.100	NA	0.017	NA	0.059	3.4e-05	NA	5.6e-02	NA	1.4e-03
6	METSIM	Adipose	0.0316	0.0182	4.4e-03	0.027	0.014	0.018	0.016	0.027	5.8e-05	3.0e-03	8.7e-04	1.7e-03	5.3e-05
7	YFS	Blood	0.0608	0.0180	1.3e-12	0.029	0.034	0.028	0.034	0.039	7.0e-10	1.8e-11	9.6e-10	2.3e-11	7.4e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.6	2.5	9.4	-0.2	-0.5	-1.3	-3.1	-1.2	-1.9	0.8
Bipolar Disorder or Schizophrenia	0.8	2.0	7.7	1.1	-0.2	0.4	-2.8	0.6	-2.1	-0.2
Depressed Affect (Nagel 2018)	0.3	0.7	2.8	-0.2	-0.7	-0.8	-0.0	-0.9	0.0	1.7
Depression (Nagel 2018)	0.3	0.5	1.4	0.5	-1.1	-0.2	0.1	-0.7	-0.0	1.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	5.1	-0.5	-0.3	1.3	2.3	1.4	-1.0	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.9	-0.4	0.4	-0.8	0.3	-0.3	1.1
Schizophrenia (2018)	0.7	1.6	2.9	1.6	0.1	1.6	-1.1	1.7	-1.1	-0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	1.7	0.0	1.7	0.5	1.5	0.4	0.4
Worry (Nagel 2018)	1.0	2.0	6.1	1.2	-0.6	0.9	-2.5	0.8	-2.0	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	0.1	0.1	1.0	1.2	1.2	1.3	0.4
Alzheimer’s Disease (in father)	2.5	2.7	6.1	-1.5	1.7	0.9	1.3	1.0	2.5	1.9
Alzheimer’s Disease (including proxy)	1.9	2.7	5.0	-0.7	1.1	1.6	2.2	1.9	2.2	1.2
Crohns Disease (2017)	0.9	1.9	4.0	-1.0	1.5	1.1	1.4	1.3	1.2	2.0
Irritable Bowel Disease (IBD)	1.0	2.3	4.8	-1.3	1.3	0.5	1.7	0.5	2.2	2.1
Ulcerative Colitis (UC)	0.7	1.3	4.2	-1.1	-0.1	-0.2	1.4	-0.3	2.0	1.3
Major Depression (MDD)	0.5	0.6	2.6	-0.6	0.7	-0.5	0.5	-0.2	-0.1	1.6
Reaction Time	0.8	1.5	4.1	0.4	-0.0	1.9	-0.5	2.0	-1.2	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.8	-0.2	-1.0	0.2	-0.3	0.3	-1.7	-0.3
Breast Cancer	2.2	5.3	16.6	3.2	-2.5	0.4	-4.1	0.0	-1.9	-0.6
Ovarian Cancer	0.5	0.6	1.7	1.0	0.3	1.3	-0.5	1.0	-0.5	-0.2
Prostate Cancer	1.0	1.5	3.9	-0.4	0.9	1.0	2.0	1.0	1.4	1.3
Age at First Birth	0.9	1.3	2.4	1.5	-0.2	1.1	-1.1	1.3	1.1	-1.3
Bipolar Disorder (2011)	1.3	1.2	2.8	-0.4	0.0	-1.6	0.8	-1.6	1.7	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	-1.3	0.8	-0.3	0.2	-0.4	-0.4	0.1
Coronary Artery Disease (CAD)	1.4	1.6	4.2	0.6	2.0	1.1	-0.9	1.4	1.2	1.3
Crohns Disease (2012)	0.9	1.5	3.6	-1.4	1.3	0.8	0.6	1.0	1.1	1.9
Mean Putamen Volume	1.6	1.9	5.5	0.9	2.4	1.8	-0.1	1.8	-0.1	0.5
Fasting Glucose	1.2	1.4	5.9	2.4	-0.5	-0.0	0.1	-0.1	-0.6	-1.9
HbA1C	1.4	1.6	3.4	-0.9	-0.8	-1.7	-0.3	-1.9	-1.3	-1.2
HDL Cholesterol	0.9	1.5	3.5	-1.0	1.3	0.4	1.9	-0.1	1.5	1.3
LDL Cholesterol	1.3	2.1	3.8	-1.9	1.5	0.4	1.7	0.5	1.9	1.3
Lupus	1.5	2.3	7.4	2.3	-2.7	-0.6	-1.5	-0.5	-0.1	-0.8
Neuroticism (2016)	0.8	1.2	2.9	1.6	-1.2	-0.6	-0.3	-0.3	0.9	1.7
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.4	-0.1	-0.3	-0.6	-0.4	0.4	0.4
Rheumatoid Arthritis	0.7	1.0	3.0	0.0	0.2	-0.5	0.7	-0.8	1.7	1.7
Schizophrenia (2014)	0.4	0.9	2.6	0.9	-0.0	1.0	-1.6	0.8	-0.7	1.0
Triglycerides	0.2	0.4	1.1	0.7	0.3	0.6	-1.0	0.6	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	0.4	0.3	-0.2	0.8	-0.6	0.1	1.7
Ulcerative Colitis	1.3	1.9	4.1	-2.0	1.1	-1.1	0.8	-1.0	2.0	1.1
Blood Eosinophil Count	1.0	7.4	16.4	4.0	0.5	2.6	-0.7	2.9	-2.5	-3.7
Blood Platelet Count	0.8	8.9	15.3	-2.5	3.9	0.1	3.5	-0.0	3.9	3.6
Blood Red Count	3.0	29.1	66.1	3.4	-8.1	-4.7	-6.9	-4.3	-4.6	-4.3
Blood White Count	0.2	1.2	2.1	0.8	-1.4	-1.5	-1.0	-1.4	0.3	0.9
Heel T-Score	0.2	1.6	4.0	0.7	-1.7	0.9	-1.2	1.1	-0.8	-2.0
BMI	1.0	5.6	20.5	-4.5	-0.1	-2.5	1.6	-2.2	-2.1	-0.7
Height	0.4	7.4	36.1	-2.6	1.2	-0.2	-6.0	-1.8	-1.9	0.8
Waist Hip Ratio (WHR)	0.3	1.3	3.8	-0.7	-1.0	-1.1	1.4	-1.0	-0.1	-1.9
Systolic Blood Pressure	3.7	18.5	35.0	4.6	-5.4	-3.3	-5.9	-3.4	-4.4	-1.1
Smoking Status	0.8	1.8	4.5	2.1	1.2	1.1	1.0	1.7	1.1	-0.8
Allergy or Eczema	0.6	1.5	2.4	-1.0	1.5	1.5	1.2	1.4	-0.3	-1.2
Cardiovascular Disease	5.5	18.2	55.9	2.8	-4.0	-2.8	-7.5	-3.1	-5.3	-1.5
Hypothyroidism (self reported)	0.4	0.8	1.8	-0.7	1.4	1.2	-0.5	1.1	-0.8	0.1
Respiratory disease	0.5	1.2	5.1	-1.4	0.3	0.3	2.2	0.2	1.0	-0.1
Type 2 Diabetes (T2D) (2018)	4.0	7.6	13.8	-2.5	-2.4	-3.7	-1.9	-3.5	-2.4	-2.4
Lung FEV1/FVC ratio	0.4	1.9	5.8	2.4	0.2	-0.1	-2.2	0.2	-1.5	-0.3
Lung FVC	2.2	10.9	31.2	0.6	3.8	3.1	1.8	3.0	3.0	5.6
Neuroticism	0.2	0.4	1.3	0.8	-0.1	0.2	-1.2	0.2	-0.3	1.0
Chronotype (morning person)	0.9	2.0	8.8	-3.0	-0.0	-1.6	-0.1	-1.6	-0.5	0.1
Hair Pigment	0.0	0.9	3.3	1.2	0.2	0.6	0.8	0.3	1.8	0.3
Tanning	0.4	5.3	18.0	-4.2	1.6	-0.8	1.9	-0.8	2.0	2.7
Hand grip strength (left)	2.2	5.7	13.7	-3.7	1.2	-1.8	1.4	-2.5	1.8	3.3
Number of treatments/medications taken	0.1	0.3	0.7	0.1	0.9	0.4	-0.2	0.1	-0.4	0.8
Average weekly spirits intake	0.6	0.8	1.9	0.1	1.4	1.0	1.1	0.9	0.7	0.3
Sensitivity / hurt feelings	0.2	0.3	0.6	0.7	0.7	0.6	-0.2	0.5	0.4	0.2
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.9	1.0	0.7	0.5	1.2	0.1	0.5	1.7
Hearing difficulty/problems: Yes	2.0	3.1	8.8	-1.2	3.0	1.6	0.3	1.4	0.6	2.6
Relative age of first facial hair	0.2	0.4	1.2	-0.6	0.7	0.2	0.1	0.2	-0.9	-1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.7	-2.2	0.6	-0.2	1.5	-0.8	0.1	1.5
Ever used hormone-replacement therapy (HRT)	2.7	3.5	8.6	2.7	-2.1	0.8	-0.6	0.7	-1.6	-2.9
Ever had hysterectomy (womb removed)	1.2	1.3	4.0	0.7	-0.4	0.8	-2.0	0.4	-0.4	1.9
Systolic blood pressure, automated reading	1.4	4.0	9.5	1.8	-2.0	-1.9	-3.1	-1.9	-2.0	-0.0
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.7	-0.7	-0.1	-1.3	-2.2	-1.6	-2.1	-1.5
Angina	0.4	0.5	1.5	0.4	1.2	0.6	-0.8	0.7	-0.2	-0.5
Medication for hormone replacement therapy	1.7	1.9	4.3	1.5	0.9	2.1	1.3	2.0	0.7	0.1
Vitamin and mineral supplements	0.3	0.4	1.0	0.6	-0.4	0.5	0.0	0.6	1.0	0.9
Supplements: Zinc	1.9	2.1	5.1	-1.0	-1.6	-1.7	-0.8	-1.2	-0.9	-2.3
Medication: Co-codamol	1.1	1.3	2.5	-1.0	0.6	1.0	1.6	0.8	1.5	1.1
Medication: Metformin	3.2	4.5	8.8	-0.9	-2.4	-2.7	-1.5	-3.0	-1.6	-1.8
Diabetes (father)	1.5	1.9	3.3	-1.6	-0.9	-1.5	-1.5	-1.8	-1.4	-0.4
Diabetes (mother)	0.8	1.0	3.9	2.0	-0.9	-0.3	-0.5	-0.4	0.3	-1.3
Severe depression (siblings)	0.3	0.3	1.2	-0.0	-1.1	-0.1	-0.0	-0.1	-0.0	1.0
Pack years adult smoking proportion	0.8	1.2	4.3	-0.9	0.2	-1.3	0.7	-1.0	2.1	0.5
Impedance of leg (right)	0.4	2.1	5.9	2.4	-0.6	1.3	-2.3	1.0	-0.0	0.5
Leg fat-free mass (left)	0.9	4.7	22.2	-4.7	1.4	-1.7	1.0	-1.9	0.1	1.2
Trunk fat percentage	0.5	2.0	6.7	-2.6	-1.0	-1.4	0.7	-1.4	-0.6	-1.2
Hand grip strength (right)	0.9	2.5	7.1	-2.7	1.2	-1.2	0.8	-1.8	0.9	1.7
Townsend deprivation index at recruitment	0.4	0.6	1.1	-0.2	0.4	-1.0	0.9	-1.1	-0.4	0.9
Current tobacco smoking	0.4	0.7	2.1	0.8	0.5	-0.1	-0.6	0.1	1.1	1.4
Average weekly fortified wine intake	0.2	0.2	0.4	-0.7	-0.1	-0.3	-0.6	-0.4	0.6	-0.2
Maternal smoking around birth	1.0	1.5	4.0	-0.5	0.5	0.9	2.0	1.1	1.6	1.1
Fed-up feelings	0.8	1.5	3.5	-0.7	-1.8	-1.2	0.4	-1.4	0.3	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	5.6	0.2	-0.7	0.1	1.6	-0.4	0.7	2.4
Relative age voice broke	1.6	2.5	3.5	1.9	1.2	1.3	-1.6	1.4	-1.6	-1.8
Taking other prescription medications	0.5	0.7	1.8	0.8	1.3	1.4	0.1	0.9	-0.1	0.2
Age when periods started (menarche)	2.4	5.9	15.8	0.7	3.3	2.8	-0.0	2.2	1.2	4.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.3	1.1	0.8	1.8	0.3	1.7	-0.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.3	0.7	-1.4	-0.4	-1.1	-0.2	-0.7	-1.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.0	1.0	1.2	0.0	-0.6	0.4	-1.4	-1.1
Qualifications: CSEs or equivalent	1.5	2.0	5.0	-0.6	-1.8	-2.1	1.0	-2.2	0.4	-0.5
Serious illness, injury or assault to yourself	1.8	2.1	4.4	-1.1	2.1	0.9	1.3	0.8	1.8	1.7
High blood pressure	5.2	14.6	37.0	4.5	-3.5	-0.9	-6.1	-1.1	-5.3	-1.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.2	-1.5	1.1	0.7	1.4	0.6	-0.4	-1.2
Multivitamins +/- minerals	0.9	1.2	3.1	-1.3	1.4	-0.1	1.8	-0.3	0.5	1.0
Stomach or abdominal pain in last month	0.7	0.8	1.4	-0.8	-1.2	-0.3	1.0	-0.2	1.1	1.2
Supplements: Glucosamine	2.6	3.5	8.0	-2.4	1.6	0.5	2.8	0.9	2.6	0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.8	-0.8	0.3	-0.0	1.6	-0.1	2.0	1.3
Medication: Atenolol	2.6	3.2	9.8	-0.0	-1.3	-2.1	-3.1	-1.9	-1.8	-0.1
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.7	0.6	0.4	-0.3	0.2	0.3	0.6
Sitting height	0.7	5.2	23.0	-2.0	2.7	0.1	-1.0	-0.7	0.7	4.8
Chronic bronchitis/emphysema (father)	2.8	3.3	8.1	-0.4	1.4	1.7	1.0	1.1	2.8	2.8
High blood pressure (mother)	0.7	1.1	3.8	1.6	-0.5	0.2	-0.6	0.4	-2.0	-0.5
Body mass index (BMI)	1.4	6.0	20.0	-4.5	-0.6	-2.5	3.2	-2.2	0.8	-0.1
Impedance of leg (left)	0.5	2.4	8.4	2.9	-1.1	1.1	-2.4	0.7	-0.5	-0.1
Leg predicted mass (left)	0.9	4.7	22.2	-4.7	1.4	-1.7	1.1	-1.8	0.1	1.1
Trunk fat mass	0.6	2.7	12.7	-3.6	-0.1	-1.5	0.9	-1.5	-0.3	-0.6
Waist circumference	1.5	5.4	20.8	-4.6	-0.3	-2.3	2.6	-2.2	0.2	-0.5
Number of incorrect matches in round	0.1	0.2	0.8	-0.0	-0.3	-0.5	-0.4	-0.5	-0.2	-0.9
Past tobacco smoking	1.5	2.7	4.9	-2.2	-1.6	-1.8	-1.7	-2.1	-0.0	1.1
Alcohol usually taken with meals	0.4	0.6	2.1	-0.7	0.4	-0.1	-0.4	-0.1	-1.5	-1.1
Nervous feelings	0.8	1.5	2.8	1.0	0.2	1.5	-1.7	1.4	-1.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.2	1.3	-0.3	0.5	0.6	0.5	2.1	0.8
Hearing difficulty/problems with background noise	2.9	4.7	14.4	-2.3	3.8	1.8	2.1	1.9	1.1	1.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	-0.7	-0.4	-0.8	0.6	-0.9	-0.9	-1.1
Had menopause	1.4	1.7	4.4	0.9	-0.8	0.5	-1.2	0.6	-2.1	-2.1
Had other major operations	0.9	1.2	3.7	-0.2	0.5	0.4	1.9	0.3	1.5	1.3
Forced vital capacity (FVC)	2.2	8.4	26.0	-1.0	3.7	2.7	-0.3	2.5	2.2	5.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.5	-0.3	-1.5	-0.6	-1.0	-0.6	-1.6	-1.0
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	4.5	-1.8	1.8	-0.9	1.0	-1.1	2.1	1.7
Qualifications: None of the above	0.2	0.3	0.9	0.9	-0.6	0.1	-0.8	-0.1	-0.5	-0.4
Financial difficulties in last 2 years	1.6	2.2	7.7	-1.6	-1.2	-0.7	2.8	-0.7	1.5	0.7
Mouth/teeth dental problems	0.8	1.2	4.4	1.0	-1.3	-0.3	-2.1	-0.3	-0.7	0.7
Heart attack	0.9	1.1	4.6	2.2	-0.9	0.8	-0.9	0.7	0.4	0.3
Allergy	0.6	1.3	4.4	1.7	-0.5	-0.7	-2.1	-0.5	-0.7	0.9
Pain all over the body in last month	0.3	0.3	1.1	0.2	-0.8	-0.1	0.7	-0.1	-0.1	-1.0
Diabetes (self-reported)	3.3	5.1	10.1	-1.5	-2.4	-3.2	-1.2	-3.1	-2.0	-1.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	0.8	0.8	1.1	0.8	1.0	-0.5	-0.7
Medication: Ramipril	3.2	4.1	9.7	1.4	-1.9	-1.1	-2.7	-1.2	-3.1	-2.0
Medication: Simvastatin	5.8	8.5	15.6	-0.7	-3.5	-3.6	-3.2	-4.0	-2.0	-1.8
Fluid intelligence score	0.6	1.3	3.5	-0.4	-1.9	-0.4	-0.1	-0.6	-1.8	-1.2
Illnesses of siblings	0.8	1.1	2.2	-1.3	1.2	0.3	1.5	0.5	1.4	0.5
Neuroticism score	0.3	0.5	3.4	0.3	-0.2	0.3	-0.3	0.2	-0.0	1.9
Weight	1.1	5.3	25.4	-5.0	0.7	-2.0	1.5	-2.1	0.2	0.5
Impedance of arm (right)	2.2	10.0	25.3	5.0	-2.3	2.0	-4.6	1.6	-2.8	-2.1
Arm fat percentage (right)	0.7	2.7	6.1	-2.5	-1.5	-1.9	1.3	-1.6	-0.7	-1.6
Trunk fat-free mass	0.7	4.2	17.8	-4.2	2.2	-1.0	0.7	-1.1	0.8	1.8
Hip circumference	1.2	5.2	23.4	-4.8	-0.4	-2.5	0.8	-2.4	-0.1	0.1
Time employed in main current job	0.5	0.5	1.1	-0.4	-0.9	-0.6	0.6	-0.5	0.8	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	2.0	1.4	-1.3	0.4	1.1	0.2	0.6	1.0
Father’s age at death	2.3	3.1	15.0	-1.5	3.9	1.5	0.1	1.4	-0.7	-0.0
Worrier / anxious feelings	0.6	1.1	4.0	2.0	-0.5	0.8	-0.8	0.7	-0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	8.6	-2.2	-0.1	-1.3	2.9	-1.4	2.3	0.7
Falls in the last year	0.5	0.6	2.1	-1.4	-0.2	-0.2	-0.3	-0.1	0.7	1.2
Hair/balding pattern: Pattern 3	1.1	1.6	4.4	1.3	-1.6	-0.7	-2.1	-0.8	-1.1	0.1
Number of live births	0.9	1.2	4.2	0.2	-1.1	-0.9	-2.0	-1.0	-0.7	0.9
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	20.1	-0.6	3.5	2.2	-0.1	2.1	1.9	4.5
Pulse rate	1.0	1.7	4.4	-2.1	-0.1	-1.6	0.5	-1.4	1.5	0.5
Happiness	1.4	1.7	4.0	-2.0	0.4	-1.9	0.2	-2.0	0.4	0.5
Noisy workplace	1.1	1.3	3.2	-0.7	1.0	0.7	1.8	0.5	1.4	1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-2.1	0.2	-0.6	1.9	-0.5	2.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.5	-0.2	-0.0	-1.4	-0.0	-1.0	-2.1	-2.0
Mouth/teeth dental problems: Dentures	0.6	1.1	4.7	-2.2	1.1	-0.7	-0.0	-1.0	-0.5	0.2
Asthma	0.4	0.7	2.0	-1.2	-0.3	0.3	1.4	0.0	1.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	6.3	-2.5	1.7	0.2	2.2	0.7	1.6	1.2
Medication: Cholesterol lowering	2.5	3.9	8.0	0.2	-2.2	-1.6	-2.8	-2.0	-2.8	-0.6
Depression (self-reported)	1.1	1.3	3.1	-1.5	0.4	-1.8	1.1	-1.5	-0.1	0.4
Medication: Lansoprazole	0.2	0.2	0.8	0.5	0.6	0.0	0.2	0.0	0.2	-0.9
Prospective memory result	0.7	0.8	4.0	0.5	-2.0	-0.6	-1.0	-0.4	-0.2	-0.0
Lung cancer (father)	1.8	2.1	4.8	1.6	-2.2	-1.1	-1.5	-1.2	-1.0	-1.2
Illnesses of mother	1.4	1.7	6.6	-2.6	-0.0	-1.0	0.7	-1.0	1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	16.9	-0.4	3.2	2.1	-0.1	1.8	1.5	4.1
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	-0.6	-1.0	-0.4	-0.4	-0.1	1.4	0.9
Impedance of arm (left)	2.1	9.5	22.8	4.8	-2.5	1.7	-4.6	1.2	-2.8	-2.3
Arm fat mass (right)	0.9	3.7	14.3	-3.8	-0.9	-2.0	1.4	-2.0	-0.4	-0.7
Trunk predicted mass	0.7	4.1	17.7	-4.2	2.1	-1.0	0.7	-1.2	0.7	1.7
Standing height	0.4	4.0	13.1	-1.6	2.8	0.7	-3.6	-0.1	-1.3	1.4
Length of working week for main job	0.3	0.3	0.8	0.0	-0.8	-0.9	0.3	-0.7	0.5	-0.2
Exposure to tobacco smoke at home	0.4	0.5	1.3	0.5	-0.8	-0.1	1.1	-0.0	-0.6	0.9
Breastfed as a baby	0.6	0.7	1.0	-0.8	1.0	0.9	0.9	0.9	-0.0	1.0
Tense / ‘highly strung’	0.2	0.3	1.4	0.5	0.0	0.4	-0.5	0.4	0.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.8	-1.2	1.7	-0.5	0.7	-0.5	-0.0	1.3
Hair/balding pattern: Pattern 4	0.7	1.6	8.2	-1.1	0.6	0.9	-0.1	0.5	0.4	2.9
Birth weight of first child	1.4	2.5	6.4	-0.5	2.5	2.2	0.8	2.0	0.7	0.9
Peak expiratory flow (PEF)	1.5	3.5	11.0	3.3	0.6	1.7	-2.6	1.4	-1.4	0.2
Pulse wave reflection index	0.5	0.6	1.5	0.0	-0.3	0.8	-0.2	0.7	1.1	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.6	-1.1	-1.0	-1.4	0.4	-1.6	0.1	0.4
Loud music exposure frequency	0.6	0.7	1.7	0.4	1.3	0.8	-0.3	0.5	0.7	1.2
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.6	-2.4	-0.8	-1.2	2.0	-1.1	2.3	0.8
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	9.1	1.1	1.1	1.4	3.0	1.9	1.4	-0.3
Blood clot in the leg (DVT)	0.4	0.5	2.8	-0.2	-0.3	-0.2	0.7	-0.5	1.7	0.1
Medication: Paracetamol	2.9	4.8	10.0	-3.1	1.8	0.6	3.2	0.8	1.6	2.7
Headache pain in last month	0.3	0.5	1.5	-0.8	0.4	-0.5	-0.8	-0.3	-0.7	1.2
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	8.7	-1.2	2.0	1.0	3.0	1.5	2.7	0.6
Glaucoma (self-reported)	0.6	0.8	1.8	0.1	0.7	1.1	-0.1	1.3	0.4	1.3
Gout (self-reported)	0.9	1.3	2.9	1.3	-0.5	1.7	-0.1	1.4	-0.6	1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.6	0.3	0.9	-0.3	0.6	-0.4	1.1
Medication: Amlodipine	2.1	2.9	8.4	1.3	-1.6	-0.4	-2.9	-0.5	-2.2	-1.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.5	-0.0	1.6	1.1	0.6	0.4	0.4	1.1
Birth weight	0.2	0.4	1.2	1.1	0.4	0.8	0.2	0.9	0.3	0.2
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.5	0.3	0.5	0.9	2.7	1.0	2.1	-0.6
High blood pressure (siblings)	0.7	0.9	3.0	1.7	-0.3	0.7	-1.6	0.3	-0.6	-0.3
Forced vital capacity (FVC), Best measure	2.0	7.5	22.3	-0.4	3.7	2.7	0.1	2.3	2.0	4.7
Body fat percentage	0.7	2.8	9.1	-3.0	-0.9	-1.9	1.2	-1.9	-0.3	-1.0
Leg fat percentage (right)	1.0	3.7	11.7	-3.4	0.0	-1.8	2.8	-1.7	0.7	0.2
Arm fat-free mass (right)	1.2	6.3	27.3	-5.2	1.8	-1.9	1.5	-2.1	0.9	1.6
Exposure to tobacco smoke outside home	1.8	2.4	5.9	-2.4	-0.4	-2.1	1.4	-1.9	0.3	0.8
Comparative body size at age 10	0.1	0.4	2.0	-1.4	0.5	-0.1	-0.0	0.1	0.5	-0.3
Number of full brothers	1.8	2.2	5.2	-1.5	1.4	0.6	1.8	0.5	1.6	2.3
Worry too long after embarrassment	0.3	0.5	2.2	-0.3	0.3	0.3	0.8	0.3	1.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.2	0.5	1.5	0.8	1.1	0.7	1.5	-0.0
Wheeze or whistling in the chest in last year	0.9	1.6	8.4	-1.3	0.2	-0.0	2.9	0.2	0.8	-0.3
Number of children fathered	1.0	1.2	1.9	-0.6	1.4	0.9	1.4	0.9	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	4.8	5.7	10.8	3.0	2.1	3.3	-0.5	3.1	-2.3	0.3
Age at first live birth	0.5	1.0	2.9	0.4	1.0	1.1	-1.7	1.1	0.2	-0.3
Pulse wave peak to peak time	0.7	0.9	2.4	0.6	1.4	0.5	0.2	0.3	-1.5	-1.0
Health satisfaction	2.7	3.5	11.0	-3.3	1.5	-2.0	1.2	-1.8	1.2	0.9
Shortness of breath walking on level ground	0.3	0.4	1.8	-0.1	0.2	0.1	-0.6	0.4	-0.6	-1.3
Qualifications: College or University degree	0.3	0.9	2.1	-1.4	1.3	0.8	0.3	1.2	0.6	-0.1
Eye problems/disorders: None of the above	0.9	1.1	1.8	0.2	-1.4	-1.1	0.4	-1.0	-1.3	-1.2
Mouth/teeth dental problems: Loose teeth	3.5	4.2	11.2	-2.2	2.0	0.2	3.3	0.2	2.4	1.7
Emphysema/chronic bronchitis	1.1	1.3	2.7	0.2	1.4	1.1	1.6	1.2	1.2	-0.6
Medication for pain relief, constipation, heartburn	1.0	1.7	4.6	0.7	-0.9	-0.8	-1.8	-1.2	-0.7	-2.1
Neck or shoulder pain in last month	0.4	0.5	1.6	-0.6	1.3	0.4	1.2	0.4	0.1	0.2
Medication: Blood pressure	2.1	3.7	7.9	1.7	-2.2	-0.9	-2.8	-1.4	-2.7	-0.5
Angina (self-reported)	0.5	0.7	1.5	0.9	1.2	0.8	-1.0	0.9	-0.2	-0.5
Migraine (self-reported)	0.8	1.0	3.6	0.1	-0.9	-0.7	-1.9	-0.9	-0.9	0.9
Medication: Ibuprofen	2.1	2.5	6.6	-2.6	0.5	-0.2	2.0	0.2	1.8	1.8
Medication: Allopurinol	0.9	1.2	2.9	1.3	-0.3	1.7	0.0	1.5	-0.0	1.3
Medication: Omeprazole	1.5	1.8	4.7	1.1	-1.2	-0.5	-1.2	-0.3	-2.0	-2.2
Medication: Seretide 50 evohaler	0.8	1.0	3.0	-0.4	0.8	1.3	0.8	0.7	-0.4	1.7
Mean time to correctly identify matches	1.2	2.2	5.2	0.8	0.2	2.2	-0.8	2.3	-1.9	0.5
Heart disease (mother)	0.9	1.1	4.6	-0.2	-0.6	-1.0	-2.1	-1.1	-0.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.3	0.8	-0.6	-0.6	-0.1	-0.6	-0.6	-1.5
Whole body fat mass	0.8	3.5	14.3	-3.8	-0.5	-1.9	1.4	-1.9	-0.4	-0.5
Leg fat mass (right)	1.4	5.5	20.7	-4.5	0.1	-2.3	2.6	-2.3	0.7	0.3
Arm predicted mass (right)	1.1	5.5	25.6	-5.1	1.7	-1.8	1.3	-1.9	0.5	1.2
Pulse rate, automated reading	2.0	6.6	14.8	-3.0	-0.8	-2.1	3.9	-2.1	2.8	2.2
Alcohol intake frequency.	2.6	6.1	19.4	1.9	-2.5	-2.0	-4.4	-2.1	-2.1	-0.9
Comparative height size at age 10	0.2	1.1	5.3	-0.4	1.0	-0.1	-2.3	-0.4	-0.9	0.5
Number of full sisters	1.6	2.0	8.4	-0.6	1.3	0.9	1.5	0.4	-0.6	2.9
Suffer from ‘nerves’	1.1	1.7	3.9	0.9	-1.9	0.3	-1.7	0.3	-2.0	-0.7
Overall health rating	0.8	1.6	3.7	-1.3	0.3	-0.5	1.3	-0.7	1.9	1.9
Chest pain or discomfort	0.1	0.1	0.4	-0.0	0.1	0.1	0.6	0.1	0.4	-0.2
Had major operations	1.0	1.2	2.8	-1.0	1.0	-0.3	1.7	-0.2	1.5	1.1
Age at last live birth	1.2	1.7	3.6	1.0	1.1	1.5	-1.9	1.0	0.9	1.4
Family relationship satisfaction	2.3	2.8	6.4	-2.5	-0.9	-2.4	0.1	-2.3	0.7	0.7
Leg pain on walking	2.1	2.7	7.1	-2.7	0.1	-1.4	2.3	-1.4	1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.3	-1.2	0.5	-0.3	1.8	-0.1	1.5	1.7
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.5	-2.1	0.7	-1.1	0.3	-1.2	2.0	1.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	1.0	-0.7	0.4	-1.3	0.3	-0.6	-0.9
Medication: Aspirin	1.2	1.6	7.6	1.4	0.2	0.2	-1.2	0.0	-2.8	-0.6
Supplements: Vitamin C	1.4	1.7	8.4	-0.4	-0.8	-0.3	-0.9	0.1	-1.3	-2.9
Knee pain experienced in last month	2.7	4.2	18.0	-1.4	1.4	-0.1	4.2	0.3	2.6	0.9
Hypertension (Self-reported)	5.2	14.4	39.4	4.6	-2.8	-0.3	-6.3	-0.6	-5.4	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.4	1.6	0.7	1.3	1.4	1.3	0.4	0.6
Illnesses of father: Heart disease	0.3	0.5	1.7	-0.1	-0.4	-0.3	-0.8	-0.4	0.8	1.3
Illnesses of siblings: Diabetes	0.6	0.7	2.7	-0.1	-0.7	-0.6	-0.2	-1.0	-1.6	0.5
Smoking status: Previous	1.8	2.7	4.5	1.8	1.8	1.7	1.9	2.1	-0.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.1	-1.4	0.9	0.1	-1.4	-0.0	-0.4	-0.2
Whole body fat-free mass	0.8	4.7	21.3	-4.6	1.9	-1.4	1.1	-1.5	0.6	1.4
Leg fat-free mass (right)	0.8	4.2	19.4	-4.4	1.4	-1.7	1.0	-1.8	-0.0	1.0
Arm fat percentage (left)	0.8	3.2	7.5	-2.7	-1.7	-2.1	1.4	-1.9	-0.6	-1.4
Average weekly red wine intake	0.8	1.1	3.5	-1.9	-0.1	-0.7	1.6	-0.5	-0.1	-1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.2	0.6	0.1	0.5	1.3	0.8	1.5	-0.3
Mood swings	0.5	0.9	3.7	0.7	-0.3	-0.5	-0.3	-0.6	1.2	1.9
Loneliness, isolation	1.4	1.9	4.9	-1.5	-0.9	-1.9	0.3	-2.2	-0.9	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.3	-0.1	0.6	1.0	0.1	1.4	1.1
Ever had bowel cancer screening	0.7	0.9	2.4	-1.1	0.4	0.3	-0.3	0.3	-1.4	-1.6
Diabetes diagnosed by doctor	4.2	6.9	10.6	-1.8	-2.7	-3.2	-1.9	-3.2	-2.9	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.9	-2.2	1.3	-1.2	1.7	-1.1	1.9	1.1
Friendships satisfaction	1.5	1.9	3.5	-1.6	-1.4	-1.9	-1.1	-1.8	-0.9	-0.3
Qualifications: nursing, teaching	0.5	0.7	3.1	-0.4	1.8	1.0	0.1	0.8	0.4	-0.3
Commuting to job workplace: Walk	1.3	1.4	4.5	1.0	-0.8	0.3	-0.9	0.3	-2.1	-1.6
Eye problems/disorders: Cataract	0.5	0.6	1.5	0.1	1.2	0.6	-0.7	0.7	-0.1	1.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	6.8	1.2	-1.9	-0.5	-1.1	-0.7	-1.6	-2.6
Medication for cholesterol	1.5	2.3	7.6	-2.7	1.6	-0.3	1.2	-0.2	1.6	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.5	-0.7	-0.0	-0.3	0.4	-0.4	-0.6	1.9
Back pain experienced in last month	0.8	1.2	4.6	-2.2	1.7	-0.3	0.3	-0.1	0.9	-0.3
Mineral and other dietary supplements	0.8	1.1	1.9	1.3	-1.3	-0.4	-1.1	-0.9	-0.3	1.4
Breast cancer (self-reported)	0.7	0.8	3.2	-0.4	1.8	0.7	-0.7	0.9	-0.1	-0.8
Asthma (self-reported)	0.3	0.6	2.0	-1.1	-0.4	0.3	1.4	-0.1	0.8	-0.3
Osteoporosis (self-reported)	0.9	1.1	2.4	1.6	-0.5	1.6	-0.3	1.3	0.6	-0.4
Osteoarthritis (self-reported)	1.6	2.1	6.0	-2.2	-0.1	-0.3	2.5	-0.2	1.9	-0.3
Medication: Aspirin	1.4	1.8	8.2	1.6	-0.0	0.2	-1.2	-0.1	-2.9	-0.3
Medication: Gliclazide	3.5	4.0	8.6	-1.3	-2.8	-2.7	-0.8	-2.9	-0.6	-1.2
Illnesses of father: None of the above (group 1)	1.9	2.3	5.1	1.2	-1.9	-0.5	-2.3	-0.2	-1.4	-2.0
Smoking status: Current	0.3	0.4	1.0	0.6	0.4	-0.4	-0.5	-0.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	10.7	-1.0	1.3	0.6	1.3	0.9	0.4	3.3
Whole body water mass	0.8	4.7	21.4	-4.6	1.8	-1.4	0.9	-1.6	0.5	1.5
Leg predicted mass (right)	0.8	4.1	19.0	-4.4	1.3	-1.7	1.0	-1.9	-0.0	1.0
Arm fat mass (left)	1.0	4.2	14.6	-3.8	-1.2	-2.3	1.7	-2.2	-0.4	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	4.5	2.1	-1.1	0.3	-2.1	-0.2	-1.1	-0.7
Average weekly champagne plus white wine intake	0.7	1.0	3.5	-1.1	1.4	-0.2	1.9	-0.1	0.2	-0.0
Miserableness	1.9	3.3	10.2	-0.7	0.8	1.0	3.2	0.9	1.6	2.7
Guilty feelings	0.7	1.1	7.3	-0.2	0.0	0.5	-0.3	0.1	0.1	2.7
Wears glasses or contact lenses	0.8	0.9	3.7	-1.9	0.9	-0.5	-0.2	-0.2	-1.2	0.2
Ever taken oral contraceptive pill	3.1	3.4	11.0	-1.5	1.7	0.6	3.3	0.7	1.9	1.9
Hearing aid user	1.3	1.5	5.4	-0.4	1.4	1.2	-1.1	0.7	0.3	2.3
Mother’s age at death	2.2	2.8	5.0	1.8	1.6	1.4	-1.6	1.7	-1.1	-2.2
Financial situation satisfaction	2.0	2.5	9.2	-1.8	1.2	-0.6	3.0	-0.4	1.5	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.9	0.2	-0.7	-0.1	-1.7	-0.5	-0.7	-0.4
Commuting to job workplace: Public transport	0.9	1.1	2.3	-1.2	-0.3	-0.9	0.6	-1.0	-1.5	-1.2
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	0.5	0.9	1.3	-0.6	1.5	0.8	1.1
Medication: Blood pressure	4.3	8.2	21.4	3.6	-1.8	-0.0	-4.0	-0.1	-4.6	-1.9
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.5	-0.7	1.9	1.2	1.9	0.9	1.3	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	-0.8	0.1	-0.2	-0.4	-0.0	-1.2	-0.7
High cholesterol (Self-reported)	2.8	5.0	8.4	-0.2	-2.8	-2.1	-2.9	-2.2	-2.8	-1.2
Medication: Bendroflumethiazide	1.5	2.3	8.2	2.4	0.2	0.8	-2.9	0.5	-1.2	0.1
Medication: Paracetamol	3.1	4.9	11.3	-3.3	1.6	0.0	3.4	0.1	1.8	2.5
Medication: Lisinopril	1.6	2.1	4.7	1.7	-2.2	-0.7	-1.5	-1.2	-1.5	0.6
Medication: Atorvastatin	1.0	1.2	4.1	0.9	0.7	0.6	-1.4	0.7	-2.0	-0.5
Illnesses of father: High blood pressure	0.6	0.7	3.5	-0.4	0.2	-0.8	1.9	-0.7	-0.6	-0.2
Alcohol drinker status: Never	0.5	0.6	2.0	1.4	-0.7	-0.2	-0.6	-0.4	-0.4	-0.9
Ever smoked	1.1	1.9	6.2	2.5	0.5	1.0	1.1	1.3	-0.6	-1.5
Basal metabolic rate	0.9	5.0	23.6	-4.9	1.5	-1.7	1.1	-1.8	0.4	1.2
Leg fat percentage (left)	0.9	3.4	9.6	-3.1	-0.1	-1.8	2.8	-1.7	0.4	-0.3
Arm fat-free mass (left)	1.0	5.1	23.3	-4.8	1.5	-1.8	1.5	-1.8	0.7	1.1
Number of operations (self-reported)	2.0	2.9	8.4	-0.1	1.0	1.0	2.9	1.2	2.5	1.6
Average weekly beer plus cider intake	1.2	1.8	6.8	2.6	-0.5	1.3	-0.3	1.0	1.0	1.2
Irritability	0.2	0.4	1.1	-0.1	-0.3	-0.6	0.9	-0.4	1.0	-0.4
Risk taking	0.3	0.5	2.4	-0.2	0.3	0.4	1.6	0.3	-0.1	0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.3	0.1	0.1	-0.4	0.6	-0.2	-1.0	-2.1
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-0.4	1.4	0.2	0.8	1.0	0.9	-0.8
Age started oral contraceptive pill	1.0	1.2	3.1	0.1	0.7	0.8	-1.1	0.9	-1.8	-1.4
Diastolic blood pressure, automated reading	2.1	6.7	12.0	1.7	-2.8	-3.3	-3.5	-3.1	-1.5	1.0
Ever depressed for a whole week	1.7	2.1	4.8	-2.2	0.8	-1.8	1.1	-2.1	0.6	0.1
Unable to work because of sickness or disability	0.6	0.8	2.2	-0.2	1.5	0.9	0.2	0.7	0.3	1.5
Commuting to job workplace: Cycle	3.0	3.7	8.1	2.8	1.4	2.8	0.2	2.6	-0.6	-0.8
Myopia	0.4	0.6	2.1	-0.3	-1.4	-0.7	0.0	-1.0	-0.2	-0.6
Vascular/heart problems diagnosed by doctor	5.0	13.6	36.0	-4.6	3.0	0.6	6.0	0.8	5.1	1.5
Cholesterol lowering medication	1.4	2.1	3.3	-0.7	-1.0	-1.8	-1.4	-1.7	-1.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.9	1.1	-0.9	-0.1	-0.6	0.2	-1.2	-1.7
Pain experienced in last month	1.6	2.6	6.4	0.9	-2.5	-1.1	-2.2	-1.1	-1.5	-1.2
Supplements: Calcium	0.6	0.7	2.6	-0.1	-0.2	-0.7	-0.6	-0.4	-1.1	-1.6
Basal cell carcinoma (self-reported)	0.5	0.5	1.7	-0.9	1.3	0.7	0.1	0.6	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.9	2.2	-1.1	0.7	-0.9	0.6	0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.3	-0.6	-0.5	-0.6	0.9	-0.9	1.5	0.2
Heart disease (siblings)	0.7	0.9	3.4	1.8	-1.1	0.4	-0.1	0.2	-1.2	0.1
Alcohol drinker status: Previous	1.6	1.8	4.4	-1.3	0.3	-2.1	-0.8	-2.1	-0.9	0.8
Pack years of smoking	0.6	0.9	3.2	-0.9	0.2	-1.2	0.6	-0.9	1.8	0.2
Impedance of whole body	1.4	7.1	19.3	4.4	-1.6	1.7	-4.1	1.3	-2.0	-1.6
Leg fat mass (left)	1.3	5.2	18.9	-4.3	0.0	-2.3	2.6	-2.3	0.4	-0.1
Arm predicted mass (left)	0.9	4.7	22.4	-4.7	1.4	-1.5	1.4	-1.6	0.3	1.1