[Hub]/) : Traits : Lung FVC : ← →

chr15:82,250,003-86,109,582

Best TWAS P=2.52e-17 · Best GWAS P=3.99e-13 conditioned to 0.00907

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALPK3	0.14	0.13	lasso	7	0.15	5.8e-18	-4.5	5.5	4.9e-08	-0.01	0.04	0.96	TRUE
2	CommonMind	Brain Pre-frontal Cortex	BTBD1	0.07	0.01	bslmm	356	0.04	1.7e-05	-5.0	-8.5	2.5e-17	0.60	0.21	0.72	TRUE
3	GTEx	Adipose Subcutaneous	BTBD1	0.06	0.08	lasso	4	0.06	5.8e-06	5.9	-6.0	2.5e-09	0.59	0.94	0.04	FALSE
4	GTEx	Adipose Subcutaneous	WHAMM	0.46	0.45	lasso	3	0.47	2.7e-42	-5.0	5.8	8.2e-09	-0.41	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-152F13.7	0.14	0.01	enet	12	0.07	1.9e-04	-2.3	-5.5	4.1e-08	0.63	0.14	0.19	FALSE
6	GTEx	Adrenal Gland	RP11-152F13.7	0.26	0.07	enet	19	0.09	3.3e-04	4.3	-5.3	1.0e-07	0.47	0.09	0.17	FALSE
7	GTEx	Artery Tibial	BTBD1	0.10	0.09	lasso	3	0.08	6.0e-07	6.0	-5.9	4.1e-09	0.58	0.94	0.05	FALSE
8	GTEx	Artery Tibial	AP3B2	0.18	0.17	enet	12	0.15	6.7e-12	4.3	5.1	2.8e-07	-0.34	1.00	0.00	FALSE
9	GTEx	Brain Cerebellum	SCAND2P	0.18	0.10	lasso	4	0.11	4.5e-04	-4.5	-5.4	6.9e-08	0.00	0.03	0.92	FALSE
10	GTEx	Brain Cortex	BTBD1	0.33	0.13	lasso	5	0.22	7.9e-07	4.3	-5.7	1.5e-08	0.42	0.20	0.06	FALSE
11	GTEx	Brain Frontal Cortex BA9	BTBD1	0.12	0.01	enet	19	0.02	8.4e-02	4.6	-5.4	5.3e-08	0.55	0.11	0.16	FALSE
12	GTEx	Breast Mammary Tissue (Male)	BTBD1	0.08	-0.01	lasso	3	0.00	2.4e-01	-4.9	-6.7	1.7e-11	0.31	0.04	0.06	FALSE
13	GTEx	Colon Transverse	RP11-152F13.7	0.38	0.16	enet	34	0.17	1.5e-08	4.3	-6.0	2.1e-09	0.49	0.96	0.01	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	RP11-382A20.2	0.13	0.03	enet	20	0.07	1.1e-03	1.1	6.3	2.8e-10	-0.52	0.10	0.24	FALSE
15	GTEx	Esophagus Mucosa	HDGFRP3	0.20	0.12	lasso	8	0.09	2.3e-06	4.8	5.3	1.4e-07	-0.49	0.99	0.00	FALSE
16	GTEx	Esophagus Mucosa	RP11-152F13.7	0.41	0.32	enet	30	0.41	4.9e-29	4.5	-5.7	1.4e-08	0.49	1.00	0.00	FALSE
17	GTEx	Esophagus Muscularis	BTBD1	0.08	0.06	lasso	5	0.04	2.5e-03	5.8	-5.7	9.1e-09	0.58	0.42	0.38	FALSE
18	GTEx	Heart Left Ventricle	RP11-152F13.7	0.12	0.04	enet	13	0.10	6.0e-06	-1.9	-5.5	4.3e-08	0.25	0.06	0.23	FALSE
19	GTEx	Liver	WDR73	0.19	0.01	enet	20	0.01	2.0e-01	-5.2	5.2	1.8e-07	0.06	0.06	0.32	FALSE
20	GTEx	Liver	GOLGA6L9	0.15	0.00	lasso	4	-0.01	7.8e-01	7.1	-6.3	2.8e-10	0.56	0.01	0.66	TRUE
21	GTEx	Muscle Skeletal	AP3B2	0.13	0.08	enet	13	0.10	7.5e-10	4.3	6.0	1.8e-09	-0.45	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	CPEB1	0.07	0.01	enet	10	0.04	4.4e-05	1.4	5.3	1.2e-07	-0.48	0.10	0.28	FALSE
23	GTEx	Nerve Tibial	BTBD1	0.16	0.20	lasso	7	0.20	2.5e-14	5.8	-5.8	5.2e-09	0.55	0.95	0.05	FALSE
24	GTEx	Nerve Tibial	WHAMM	0.11	0.07	lasso	5	0.04	1.2e-03	-5.0	5.3	1.2e-07	-0.39	0.02	0.90	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	AP3B2	0.45	0.41	lasso	6	0.42	1.2e-24	4.3	5.4	5.9e-08	-0.44	1.00	0.00	FALSE
26	GTEx	Testis	BTBD1	0.06	0.01	enet	8	0.04	1.1e-02	4.7	-7.4	2.0e-13	0.72	0.07	0.56	FALSE
27	GTEx	Testis	RP11-152F13.7	0.18	0.02	enet	15	0.09	1.3e-04	3.7	-5.2	2.2e-07	0.46	0.12	0.10	FALSE
28	METSIM	Adipose	AP3B2	0.19	0.21	enet	12	0.21	8.7e-31	4.1	5.4	6.8e-08	-0.41	1.00	0.00	FALSE
29	METSIM	Adipose	BTBD1	0.04	0.05	enet	13	0.07	4.1e-10	5.9	-6.9	4.3e-12	0.55	0.96	0.03	FALSE
30	METSIM	Adipose	C15orf40	0.09	0.03	enet	13	0.05	6.9e-08	-2.4	5.6	2.6e-08	-0.52	0.56	0.43	FALSE
31	YFS	Blood	BTBD1	0.02	0.00	enet	19	0.01	6.2e-03	3.5	-5.8	5.3e-09	0.46	0.02	0.90	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	BTBD1	0.02	0.01	blup	48	0.01	2.5e-03	6.3	-7.0	2.0e-12	0.63	0.00	0.84	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	BTBD1	0.20	0.06	lasso	2	0.13	9.1e-05	6.3	-6.4	1.8e-10	0.56	0.01	0.87	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FSD2	0.07	0.02	blup	61	0.05	2.7e-06	7.2	5.7	1.4e-08	-0.33	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HOMER2	0.14	0.05	lasso	4	0.08	2.0e-04	4.2	6.6	3.9e-11	-0.53	0.15	0.71	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WHAMM	0.14	0.05	enet	11	0.08	1.0e-04	-5.0	6.0	1.8e-09	-0.52	0.02	0.97	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3B2	0.06	0.01	blup	54	0.03	5.1e-04	3.9	5.6	1.9e-08	-0.31	0.05	0.11	FALSE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	WHAMM	0.25	0.06	blup	55	0.09	4.2e-03	-5.0	6.6	4.4e-11	-0.52	0.02	0.69	FALSE
39	The Cancer Genome Atlas	Skin Cutaneous Melanoma	BTBD1	0.13	0.12	lasso	3	0.13	2.8e-04	4.9	-5.3	1.3e-07	0.47	0.03	0.17	FALSE
40	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WHAMM	0.14	0.17	enet	5	0.13	2.5e-04	-7.3	-7.5	5.5e-14	0.99	0.00	0.84	FALSE