Hub : Genes

HOMER2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0865	0.0345	9.3e-05	0.082	NA	0.060	NA	0.037	3.9e-05	NA	3.9e-04	NA	4.4e-03
2	GTEx	Nerve Tibial	0.2418	0.0589	6.0e-09	0.234	NA	0.199	NA	0.219	1.3e-16	NA	4.6e-14	NA	1.6e-15
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1180	0.0510	2.9e-03	0.083	NA	0.104	NA	0.099	2.5e-05	NA	2.5e-06	NA	4.7e-06
4	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0410	1.6e-07	0.077	NA	0.101	NA	0.088	6.2e-07	NA	1.0e-08	NA	1.0e-07
5	TCGA	Liver Hepatocellular Carcinoma	0.1370	0.0640	2.2e-04	0.054	0.069	0.057	NA	0.075	1.5e-03	0.00038	1.1e-03	NA	2.0e-04
6	TCGA	Lung Squamous Cell Carcinoma	0.0428	0.0239	7.5e-03	0.000	0.015	0.009	NA	0.003	3.0e-01	0.00660	2.9e-02	NA	1.4e-01
7	TCGA	Testicular Germ Cell Tumors	0.3190	0.1330	3.2e-03	-0.004	0.041	0.082	NA	0.051	4.5e-01	0.01400	8.0e-04	NA	7.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.4	2.2	6.1	2.5	1.4	0.5	1.3	-1.8	0.4	1.3
Bipolar Disorder or Schizophrenia	1.8	4.4	10.3	3.2	0.0	1.7	0.8	-3.0	1.0	2.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	-1.2	-0.6	-0.6	-1.2	-0.4	1.0	-0.8
Depression (Nagel 2018)	1.0	1.5	5.7	-1.3	-1.2	-0.8	-2.4	-0.3	0.8	0.7
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.1	-2.3	-1.1	-0.9	0.4	2.1	0.6	-2.7
Neuroticism (Nagel 2018)	0.2	0.5	1.2	-0.7	-0.8	-0.5	-0.7	-0.4	1.1	0.3
Schizophrenia (2018)	1.4	3.0	5.6	2.1	-1.1	1.7	-0.1	-2.4	1.0	2.3
Schizophrenia vs Biploar Disorder	1.2	1.6	4.8	0.4	-2.1	0.8	-0.1	-2.2	0.6	0.9
Worry (Nagel 2018)	0.5	1.1	3.2	1.8	0.1	0.9	1.0	-1.1	-0.0	1.1
Alzheimer’s Disease (in mother)	2.3	2.7	6.2	-1.4	-2.5	-1.5	-2.2	-0.4	0.9	-1.7
Alzheimer’s Disease (in father)	3.1	3.4	9.6	-2.3	-1.0	-2.2	-3.1	0.1	1.3	-1.0
Alzheimer’s Disease (including proxy)	2.0	3.0	8.1	-2.0	-1.7	-1.8	-2.8	-0.5	0.0	-1.6
Crohns Disease (2017)	0.5	1.0	2.0	-1.4	-1.1	-0.2	-1.4	0.3	1.3	-0.1
Irritable Bowel Disease (IBD)	1.0	2.3	6.1	-2.2	-1.4	-1.2	-2.5	0.8	0.8	-0.7
Ulcerative Colitis (UC)	0.7	1.4	3.8	-1.6	-0.5	-1.2	-2.0	0.7	-0.2	-0.9
Major Depression (MDD)	1.7	2.0	4.5	-0.4	-1.8	-2.1	-1.4	-1.3	1.6	-0.0
Reaction Time	1.7	3.3	6.9	2.6	1.3	2.0	2.6	-1.9	0.0	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.5	-1.3	-0.7	-1.7	-0.6	1.9	0.1	-1.3
Breast Cancer	1.8	4.4	11.0	1.6	0.5	3.3	2.9	-0.7	-2.1	2.0
Ovarian Cancer	0.1	0.1	0.4	0.3	0.7	0.3	-0.2	0.1	-0.2	-0.1
Prostate Cancer	0.3	0.4	1.4	0.0	0.9	-0.0	-0.5	1.2	-0.7	0.5
Age at First Birth	1.3	1.8	7.2	0.4	0.5	1.5	2.7	-0.2	-0.3	-1.7
Bipolar Disorder (2011)	1.5	1.5	4.9	0.9	0.2	-1.6	-0.7	-0.2	2.2	1.1
Body Mass Index (BMI) (2010)	0.9	1.3	3.1	1.6	1.8	0.3	1.2	0.3	-0.8	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	3.4	-0.9	-0.2	-1.1	-1.8	0.8	1.2	0.4
Crohns Disease (2012)	1.2	2.0	4.7	-0.8	-1.6	-1.1	-2.0	-0.7	2.2	0.7
Mean Putamen Volume	1.7	2.0	6.0	-0.4	1.5	-1.0	-0.3	1.1	-1.8	2.4
Fasting Glucose	0.4	0.5	1.8	0.7	0.0	-0.3	0.2	-1.3	-0.2	-1.0
HbA1C	1.6	1.8	6.9	-1.2	-1.6	0.9	-0.1	-0.8	-0.3	-2.6
HDL Cholesterol	0.7	1.2	4.0	1.1	2.0	0.1	0.6	0.7	-0.9	1.3
LDL Cholesterol	0.3	0.5	1.0	-1.0	-1.0	0.3	0.7	0.7	0.5	0.2
Lupus	1.2	1.9	6.0	-1.0	-1.9	-1.1	-1.1	-0.1	2.4	-0.7
Neuroticism (2016)	0.2	0.3	1.0	-0.5	-1.0	0.2	0.4	0.1	0.6	-0.2
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.2	-0.6	-0.9	-0.4	-0.8	0.6	-0.8
Rheumatoid Arthritis	0.6	0.8	3.1	-0.7	-1.1	0.6	0.8	-0.4	0.1	-1.8
Schizophrenia (2014)	1.2	2.7	6.3	1.7	-1.3	1.4	-0.0	-2.5	1.7	1.9
Triglycerides	0.6	0.9	3.7	-0.9	-1.1	0.7	-0.0	-0.3	0.5	-1.9
Type 2 Diabetes (T2D) (2012)	1.5	1.8	5.1	0.4	-0.6	-2.2	-2.2	-0.2	1.4	-0.1
Ulcerative Colitis	1.4	2.0	5.0	-2.2	-0.5	-1.1	-1.9	1.8	-0.3	-0.8
Blood Eosinophil Count	0.0	0.3	1.3	1.1	-0.3	-0.2	0.2	-0.7	0.0	0.5
Blood Platelet Count	0.5	5.7	11.4	-3.0	0.8	-3.1	-3.4	2.2	1.8	1.1
Blood Red Count	0.5	4.7	13.5	0.7	-2.3	-3.7	-2.6	-0.9	1.7	-1.7
Blood White Count	0.4	2.9	6.7	-2.6	-2.4	-0.8	-1.8	0.5	0.1	1.9
Heel T-Score	0.7	5.9	28.6	-1.1	-0.2	-1.1	-0.8	0.6	5.3	-3.0
BMI	0.5	2.6	7.1	2.7	-1.5	-2.2	-1.2	-1.0	0.1	-1.4
Height	0.4	6.9	17.1	-4.1	-3.0	-0.7	-3.6	-0.5	-2.9	0.6
Waist Hip Ratio (WHR)	0.7	2.9	12.0	-1.1	0.0	-1.4	-1.9	0.9	3.5	-0.9
Systolic Blood Pressure	0.0	0.2	0.8	-0.1	-0.1	0.3	0.0	-0.4	-0.9	0.7
Smoking Status	4.5	10.7	23.0	4.8	2.4	4.6	3.3	-2.6	-2.7	0.9
Allergy or Eczema	0.7	2.0	9.1	3.0	0.3	0.2	1.1	-1.5	1.0	0.5
Cardiovascular Disease	0.3	0.8	2.7	1.1	-1.2	-0.2	-0.2	-1.7	0.4	-0.5
Hypothyroidism (self reported)	0.4	0.9	1.9	-1.4	-1.2	1.3	-0.0	-0.2	-0.8	-1.0
Respiratory disease	0.5	1.2	3.7	1.9	0.8	0.2	1.0	0.1	0.8	1.6
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.6	1.2	-1.5	-2.3	-2.6	-1.2	0.5	1.5
Lung FEV1/FVC ratio	1.5	7.4	23.3	-4.8	-2.3	1.6	-0.7	3.1	-3.2	-0.6
Lung FVC	2.8	14.2	43.6	-4.9	1.2	1.2	1.6	6.6	-4.7	-1.9
Neuroticism	0.1	0.2	0.6	0.1	-0.5	-0.0	-0.6	-0.8	0.5	0.1
Chronotype (morning person)	0.3	0.6	2.1	0.7	1.4	0.0	0.3	0.0	-1.4	0.2
Hair Pigment	0.5	15.1	43.2	-6.6	-0.8	0.5	1.6	4.8	2.0	-5.7
Tanning	0.5	5.7	9.9	3.1	2.2	3.1	2.2	-3.1	-0.9	0.4
Hand grip strength (left)	0.6	1.7	6.2	-0.2	-0.6	1.5	1.0	0.1	-2.5	-1.4
Number of treatments/medications taken	1.5	2.6	8.9	-1.1	-3.0	0.0	-0.7	-2.2	0.8	-1.5
Average weekly spirits intake	4.1	5.1	11.1	3.3	1.9	2.3	3.0	-1.5	-1.7	1.0
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.6	-0.0	0.2	-0.4	-0.6	0.4	0.3
Frequency of depressed mood in last 2 weeks	1.7	2.4	8.0	-1.3	-2.4	-0.9	-2.8	-0.5	0.2	0.6
Hearing difficulty/problems: Yes	1.4	2.2	4.2	0.6	-2.1	-1.4	-0.8	-1.9	-0.9	2.0
Relative age of first facial hair	0.8	1.6	3.3	-1.8	-1.5	-0.3	-1.1	1.6	-0.7	-1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	5.3	-0.4	-2.3	-1.5	-1.0	-0.4	0.7	1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.8	-0.5	1.7	-0.4	0.5	1.4	0.8	0.1
Ever had hysterectomy (womb removed)	1.4	1.5	4.7	-0.5	-0.9	-1.1	-0.5	-0.7	1.8	-2.2
Systolic blood pressure, automated reading	0.2	0.5	2.2	-0.1	0.6	0.2	0.0	0.5	-0.8	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.7	1.1	-0.2	0.3	-0.1	-1.3	0.6	0.9
Angina	0.6	0.8	2.0	-1.4	-0.1	-0.6	-0.9	0.3	0.9	-1.1
Medication for hormone replacement therapy	0.3	0.4	1.3	-1.1	0.6	0.0	0.1	0.8	-0.3	-0.3
Vitamin and mineral supplements	1.8	2.4	6.3	2.5	1.3	-0.8	-0.9	-1.5	-1.3	1.8
Supplements: Zinc	1.6	1.8	5.6	-1.8	-2.4	0.3	0.1	0.4	0.5	-1.7
Medication: Co-codamol	1.4	1.7	3.8	0.1	-1.2	-1.3	-1.3	-1.4	2.0	1.1
Medication: Metformin	1.9	2.7	7.8	1.2	-1.0	-2.8	-2.2	-1.7	0.9	0.1
Diabetes (father)	1.4	1.8	4.3	1.8	-0.0	-1.4	-2.1	-0.7	0.1	1.6
Diabetes (mother)	1.8	2.4	10.3	0.5	-0.9	-1.7	-1.2	-0.5	3.2	0.6
Severe depression (siblings)	0.2	0.2	0.7	0.3	0.8	-0.2	-0.3	0.2	-0.8	0.2
Pack years adult smoking proportion	1.2	1.8	3.4	0.9	-0.2	-1.9	-1.8	-1.4	-1.5	1.2
Impedance of leg (right)	0.9	4.4	9.9	-3.0	-1.5	-0.1	-3.0	-0.4	-0.7	3.1
Leg fat-free mass (left)	0.4	2.2	6.2	1.4	-1.4	-1.5	-0.7	-1.4	-0.8	-2.5
Trunk fat percentage	1.7	6.9	18.0	-0.5	-3.6	-3.5	-4.2	-2.0	0.4	-0.4
Hand grip strength (right)	0.6	1.6	3.9	-0.7	-1.9	-0.5	-0.8	-0.9	-1.2	-2.0
Townsend deprivation index at recruitment	0.5	0.7	2.1	1.5	0.4	-0.8	-0.6	0.1	-0.2	1.3
Current tobacco smoking	2.2	3.6	6.8	2.6	0.7	1.7	0.6	-1.6	-2.6	2.2
Average weekly fortified wine intake	2.2	2.6	6.4	-2.0	-0.1	-1.7	-1.2	2.5	0.6	-1.7
Maternal smoking around birth	1.9	2.7	10.1	2.4	-0.3	0.3	-0.2	-3.2	0.3	1.6
Fed-up feelings	0.3	0.5	1.7	-0.8	-0.7	-0.1	-1.3	-0.1	0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.5	-0.6	-1.0	-1.0	-2.1	-1.2	0.9	0.4
Relative age voice broke	0.7	1.1	2.9	-1.7	-1.7	-0.6	-0.8	0.8	-0.1	0.4
Taking other prescription medications	0.7	1.1	2.6	-1.3	-1.4	-1.0	-1.6	0.4	0.4	0.4
Age when periods started (menarche)	1.0	2.4	5.2	0.1	-1.9	-2.3	-1.9	-1.4	0.4	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.2	-1.8	-0.4	-0.7	-0.2	0.6	0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	7.1	1.4	0.5	-0.1	0.1	-1.3	2.7	-1.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.2	-0.1	0.2	-0.7	-1.5	0.4	0.6	1.5
Qualifications: CSEs or equivalent	0.5	0.7	1.7	1.3	0.8	-0.1	-0.3	-1.3	0.6	0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.5	-0.7	1.2	1.2	0.1	0.5	-0.6	-0.4
High blood pressure	0.3	0.8	3.3	0.9	0.6	-0.2	-0.5	-0.4	0.7	1.8
Hayfever, allergic rhinitis or eczema	0.9	1.9	8.1	2.9	-0.1	0.1	0.7	-1.7	1.1	0.5
Multivitamins +/- minerals	2.5	3.1	9.1	-3.0	-1.8	0.3	0.0	1.4	1.8	-2.1
Stomach or abdominal pain in last month	0.5	0.6	1.5	-0.7	-0.7	-0.3	-0.9	0.2	1.2	-0.8
Supplements: Glucosamine	1.0	1.2	4.1	-1.0	-1.3	0.3	0.9	-0.3	2.0	-1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.8	-0.9	-0.7	0.2	0.0	-0.4	2.2	-1.7
Medication: Atenolol	0.4	0.5	1.7	-0.4	0.5	0.8	1.3	0.1	-0.4	-0.5
Medication: Levothyroxine sodium	0.2	0.4	1.0	-0.1	-1.0	0.9	0.3	-0.0	0.8	0.6
Sitting height	0.2	1.6	5.2	0.2	-1.5	0.6	-0.4	-1.6	-2.3	-0.4
Chronic bronchitis/emphysema (father)	1.2	1.4	3.3	1.8	-0.4	0.0	0.5	-1.4	1.4	1.5
High blood pressure (mother)	0.5	0.7	1.8	0.6	0.4	-1.3	-0.9	0.9	-0.1	-1.0
Body mass index (BMI)	0.8	3.2	8.6	1.4	-1.2	-2.9	-2.7	-0.9	0.8	-1.5
Impedance of leg (left)	0.9	4.4	12.7	-2.6	-1.3	-0.2	-3.0	-0.3	-0.8	3.6
Leg predicted mass (left)	0.4	2.2	6.3	1.4	-1.4	-1.4	-0.7	-1.4	-1.0	-2.5
Trunk fat mass	1.3	5.7	14.5	-0.0	-3.2	-3.1	-3.8	-2.0	-0.2	-0.8
Waist circumference	1.8	6.6	19.3	-0.7	-2.7	-3.8	-4.4	-0.8	1.1	-1.6
Number of incorrect matches in round	3.3	5.5	13.0	1.0	2.5	3.1	3.6	0.1	-0.3	2.9
Past tobacco smoking	2.5	4.5	11.9	-2.9	-1.5	-3.4	-2.7	0.9	0.5	-0.8
Alcohol usually taken with meals	2.9	4.7	12.2	-3.5	-3.2	-0.1	-0.4	1.5	0.2	-2.9
Nervous feelings	0.9	1.7	5.3	1.9	-0.5	-0.0	0.7	-1.4	-0.4	2.3
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	12.2	-1.2	-1.0	-2.5	-3.5	1.6	2.7	0.8
Hearing difficulty/problems with background noise	1.3	2.1	5.5	1.9	-0.3	-1.8	-0.6	-1.2	0.7	2.4
Hair/balding pattern: Pattern 2	1.6	2.0	5.7	-2.3	1.3	-0.7	-0.4	2.4	0.0	0.6
Had menopause	1.1	1.4	5.3	-1.1	1.5	0.5	0.6	2.3	-0.4	-0.7
Had other major operations	6.1	7.5	10.6	-3.2	-1.7	-2.4	-2.6	2.6	3.3	-3.0
Forced vital capacity (FVC)	1.8	7.1	19.1	-3.8	-0.6	0.8	-0.3	3.4	-4.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.3	1.6	0.9	0.0	0.1	-1.0	2.1	-1.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.4	1.4	-0.3	-0.1	0.3	-1.0	1.6	2.1
Qualifications: None of the above	0.8	1.6	7.5	-0.3	0.3	-0.0	-1.8	0.3	-0.5	2.7
Financial difficulties in last 2 years	0.5	0.7	3.3	-0.2	-0.9	-0.7	-0.1	-0.5	1.8	-0.1
Mouth/teeth dental problems	0.1	0.1	0.4	-0.2	0.6	-0.0	0.2	0.3	0.6	-0.0
Heart attack	1.1	1.4	5.1	-2.3	0.7	0.4	-0.3	1.1	-0.5	-1.6
Allergy	1.0	2.3	7.2	-2.7	0.4	0.2	-0.3	2.0	-1.7	-1.3
Pain all over the body in last month	1.6	1.8	5.0	-1.5	-1.2	-1.4	-2.2	0.8	1.1	-0.1
Diabetes (self-reported)	1.9	2.9	4.4	2.1	-1.2	-2.1	-1.5	-1.8	0.7	2.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.6	2.6	-0.8	-0.3	0.8	-2.3	1.2	0.2
Medication: Ramipril	0.3	0.4	1.4	0.5	0.0	0.3	0.8	-1.2	-0.6	0.6
Medication: Simvastatin	0.6	0.9	2.7	-1.2	-1.6	0.2	-0.9	-0.7	-0.8	-0.1
Fluid intelligence score	0.7	1.4	4.5	-1.6	-0.9	-0.2	-0.0	1.3	0.3	-2.1
Illnesses of siblings	1.7	2.4	6.2	1.4	-0.0	1.3	2.5	-1.4	-0.5	-2.2
Neuroticism score	0.2	0.5	1.7	-0.4	-1.3	0.0	-0.8	-0.6	0.8	0.0
Weight	0.8	4.1	9.8	0.6	-2.6	-2.7	-3.1	-1.5	-0.6	-1.4
Impedance of arm (right)	0.7	3.2	10.7	-2.7	-3.3	0.1	-1.2	-1.3	0.6	1.0
Arm fat percentage (right)	1.2	4.9	10.9	0.3	-2.8	-3.1	-3.3	-1.5	1.2	-1.4
Trunk fat-free mass	0.3	1.5	6.6	1.0	-0.3	0.2	0.3	-0.5	-2.6	-1.6
Hip circumference	1.6	6.7	15.4	-1.4	-3.8	-3.2	-3.9	-0.6	-1.4	-1.6
Time employed in main current job	1.5	1.7	4.3	-0.6	1.5	1.1	1.5	1.3	2.1	0.5
Alcohol intake versus 10 years previously	1.4	2.1	6.6	2.6	-0.0	0.5	0.0	-2.4	1.1	0.9
Father’s age at death	3.7	5.0	15.9	-3.6	0.7	-0.9	-0.1	4.0	1.1	-1.9
Worrier / anxious feelings	0.4	0.7	2.2	0.7	-0.2	0.4	1.5	0.1	1.2	0.7
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	9.8	-2.0	-3.0	-2.6	-3.1	0.7	0.9	0.1
Falls in the last year	1.3	1.8	6.6	-0.5	-2.6	-0.7	-1.9	-0.5	0.9	0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	1.2	0.8	0.5	0.8	-0.9	-0.2	-0.5
Number of live births	1.2	1.6	3.7	0.1	0.3	-1.9	-1.9	-1.8	0.6	0.7
Forced expiratory volume in 1-second (FEV1)	3.0	10.1	23.6	-4.9	-1.4	1.0	-0.9	4.1	-4.5	-2.4
Pulse rate	1.8	3.0	5.9	2.2	-1.6	-1.4	-1.6	-2.4	1.3	1.1
Happiness	0.2	0.3	1.0	0.4	0.6	-0.3	-0.2	0.1	-0.5	1.0
Noisy workplace	1.7	2.1	5.2	1.4	-0.6	-0.2	-0.9	-2.1	1.4	2.3
Qualifications: A levels/AS levels or equivalent	1.1	2.3	7.5	-2.1	-0.5	-0.4	-0.4	1.8	0.9	-2.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	8.6	-1.9	-2.9	-1.1	-0.8	-1.0	0.9	0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.6	-0.5	-0.7	-1.1	-0.2	-0.2	-1.1
Asthma	0.8	1.6	4.9	2.2	1.2	1.1	1.1	-0.7	0.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.7	1.0	-1.4	0.6	0.9	-2.2	-0.8	0.9
Medication: Cholesterol lowering	0.9	1.4	3.6	-1.9	-1.4	-0.6	-1.5	-1.1	-0.1	-0.2
Depression (self-reported)	0.9	1.1	1.9	-1.4	-0.8	-0.9	-0.2	1.3	1.2	-1.0
Medication: Lansoprazole	2.0	2.3	12.0	-0.6	-0.8	-1.2	-0.5	0.2	1.1	-3.5
Prospective memory result	2.6	3.2	11.1	2.0	1.1	1.1	0.7	-2.1	-0.6	3.3
Lung cancer (father)	0.4	0.5	0.9	1.0	0.1	-0.2	-0.8	-0.8	0.5	-0.8
Illnesses of mother	2.3	2.9	6.2	1.7	1.6	2.5	2.5	-0.6	-0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.7	26.8	-4.6	-1.3	1.1	-0.7	4.2	-5.2	-2.4
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	1.4	1.2	0.1	0.5	-0.5	-0.3	-0.3
Impedance of arm (left)	0.7	3.4	10.7	-2.6	-3.3	-0.6	-1.5	-1.3	0.8	1.3
Arm fat mass (right)	1.0	3.9	9.5	0.7	-2.4	-2.8	-3.1	-1.3	0.3	-1.3
Trunk predicted mass	0.2	1.4	6.5	0.9	-0.4	0.2	0.2	-0.5	-2.5	-1.5
Standing height	0.4	4.1	11.7	-2.0	-3.2	0.2	-1.4	-1.2	-3.4	-0.1
Length of working week for main job	0.2	0.2	0.5	0.7	-0.1	-0.4	0.4	-0.6	-0.2	0.4
Exposure to tobacco smoke at home	0.6	0.7	2.5	1.1	1.6	0.4	0.2	0.0	-0.3	0.8
Breastfed as a baby	1.5	1.9	4.9	-2.2	0.4	1.0	0.2	1.6	-0.4	-2.0
Tense / ‘highly strung’	1.6	2.6	7.0	2.4	0.8	1.5	1.6	-0.2	0.0	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.3	15.9	-1.7	-1.5	-4.0	-2.6	1.0	2.9	0.3
Hair/balding pattern: Pattern 4	0.6	1.6	3.1	1.3	-0.9	-1.2	-1.8	-0.5	1.7	0.8
Birth weight of first child	0.4	0.7	1.3	0.8	-1.0	-0.6	0.1	-1.1	0.4	-1.1
Peak expiratory flow (PEF)	3.8	8.8	24.5	-5.0	-2.4	-1.7	-2.4	3.0	0.8	-3.7
Pulse wave reflection index	2.8	3.5	7.3	1.7	2.3	1.7	2.7	-0.6	-2.3	-0.4
Ever highly irritable/argumentative for 2 days	1.7	2.1	9.1	1.8	0.9	0.1	0.4	-0.5	3.0	1.0
Loud music exposure frequency	0.5	0.5	1.2	0.9	1.1	-0.3	-0.2	0.5	-0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.2	0.7	0.5	0.4	1.5	-0.8	0.4	-2.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.4	0.0	-0.5	0.2	-0.1	-0.3	0.0
Blood clot in the leg (DVT)	1.1	1.4	4.0	-0.8	-2.0	-1.2	-1.4	-0.9	0.1	-0.8
Medication: Paracetamol	0.7	1.2	4.1	0.4	-2.0	0.5	-0.0	-1.6	0.6	-1.1
Headache pain in last month	0.7	1.2	2.9	1.1	-0.1	1.7	1.2	-1.6	0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.9	0.5	0.4	0.3	0.8	1.7	-0.1	-0.7
Glaucoma (self-reported)	0.3	0.4	1.5	-0.3	-0.6	-0.1	-0.9	-0.2	1.2	0.0
Gout (self-reported)	0.6	0.8	1.5	-0.4	0.7	1.0	1.1	-0.2	-1.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.5	-1.1	-1.6	0.7	-0.7	0.5	0.2	0.3
Medication: Amlodipine	0.5	0.8	2.6	-0.9	0.7	-0.7	-0.5	1.6	-0.7	0.4
Medication: Ventolin 100micrograms inhaler	1.8	2.3	6.0	2.1	-1.4	0.1	0.5	-2.5	-0.7	1.7
Birth weight	1.1	2.5	6.9	0.5	-1.1	2.2	2.6	-1.2	-1.4	-0.9
Chronic bronchitis/emphysema (mother)	2.1	2.5	9.8	0.7	-2.5	-0.5	-0.5	-3.1	-0.6	-0.3
High blood pressure (siblings)	1.5	2.2	5.8	-0.9	1.0	-1.1	-1.8	1.6	-0.8	2.4
Forced vital capacity (FVC), Best measure	2.1	7.7	25.2	-3.5	-0.9	1.0	-0.1	3.1	-5.0	-2.1
Body fat percentage	1.7	6.6	19.4	-0.3	-3.2	-3.6	-4.4	-1.8	0.5	-0.5
Leg fat percentage (right)	1.7	6.0	22.8	-0.2	-2.3	-3.5	-4.8	-1.2	0.5	0.2
Arm fat-free mass (right)	0.2	1.3	3.3	1.2	-0.2	-1.0	-0.9	-0.3	-1.8	-1.5
Exposure to tobacco smoke outside home	2.5	3.3	11.6	3.4	2.0	0.8	2.2	-1.0	-1.0	0.2
Comparative body size at age 10	1.5	4.3	16.7	4.1	1.1	1.1	0.9	-3.0	-0.7	0.6
Number of full brothers	1.0	1.3	2.3	-1.1	-0.0	-1.4	-1.5	1.1	0.6	-1.5
Worry too long after embarrassment	1.4	2.4	4.8	-1.1	-1.2	-2.1	-2.2	0.5	2.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.5	-0.1	-1.0	-1.9	-1.4	-0.5	0.9	0.6
Wheeze or whistling in the chest in last year	1.5	2.7	4.5	1.2	-1.1	-1.9	-2.1	-1.4	1.4	2.1
Number of children fathered	0.1	0.1	0.5	0.3	0.3	0.3	-0.3	0.1	-0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.2	0.0	1.1	-0.3	0.4	0.5	-0.3	-0.3
Age at first live birth	0.6	1.0	4.2	-1.1	0.4	0.3	1.1	0.5	0.5	-2.0
Pulse wave peak to peak time	0.7	0.8	2.8	-1.6	-1.7	-0.0	-0.6	0.3	0.1	0.1
Health satisfaction	2.1	2.8	8.8	-0.4	-3.0	-1.7	-1.6	-0.3	1.0	2.0
Shortness of breath walking on level ground	0.4	0.5	2.6	-0.2	0.5	0.1	0.2	0.8	1.6	0.0
Qualifications: College or University degree	0.9	2.8	8.9	-2.0	-0.1	-0.1	0.8	2.4	-0.9	-3.0
Eye problems/disorders: None of the above	1.3	1.5	3.7	-1.1	-0.2	-1.3	-1.8	1.9	-0.9	-0.0
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.4	-0.6	-1.4	-1.4	-1.6	-0.5	0.0	2.1
Emphysema/chronic bronchitis	0.9	1.1	5.3	0.1	-0.9	-0.4	-0.4	-0.8	2.3	0.6
Medication for pain relief, constipation, heartburn	1.1	1.9	6.3	1.6	2.5	0.2	1.3	1.1	-0.6	1.0
Neck or shoulder pain in last month	0.3	0.5	1.5	0.6	-0.5	0.2	0.2	-1.0	1.2	-0.3
Medication: Blood pressure	0.4	0.6	2.2	0.6	0.8	-0.3	-0.2	-1.5	-0.3	1.0
Angina (self-reported)	0.4	0.5	1.8	-1.3	-0.1	-0.7	-0.9	0.3	0.6	-0.5
Migraine (self-reported)	0.8	0.9	1.7	-1.2	-0.7	-1.0	0.2	1.3	0.7	-1.2
Medication: Ibuprofen	1.1	1.4	3.6	0.4	-1.9	1.0	1.0	-1.8	-0.5	0.7
Medication: Allopurinol	0.5	0.6	1.7	-0.7	0.0	1.0	0.7	-0.3	-1.3	-0.8
Medication: Omeprazole	2.9	3.5	8.7	-3.0	-2.0	-0.9	-2.0	2.1	0.7	1.3
Medication: Seretide 50 evohaler	0.4	0.5	1.3	0.9	-0.3	0.4	-0.0	-1.0	0.1	1.1
Mean time to correctly identify matches	0.3	0.6	1.3	0.4	0.9	0.7	1.2	0.1	0.6	1.1
Heart disease (mother)	1.6	1.9	3.5	-1.9	-1.9	-1.2	-1.9	0.4	-0.0	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	5.0	-0.6	0.1	-0.7	-0.1	-0.0	0.7	-2.2
Whole body fat mass	1.1	4.8	14.3	0.2	-2.6	-3.0	-3.8	-1.6	-0.1	-0.7
Leg fat mass (right)	1.3	5.0	16.3	0.8	-2.0	-3.3	-4.0	-1.8	0.2	-0.6
Arm predicted mass (right)	0.3	1.5	4.6	1.3	-0.5	-0.9	-0.9	-0.7	-2.1	-1.5
Pulse rate, automated reading	2.4	7.9	21.3	4.3	-2.1	-1.9	-1.6	-4.6	1.2	1.7
Alcohol intake frequency.	2.2	5.0	12.3	0.6	-2.7	-3.5	-3.2	-1.8	1.0	0.8
Comparative height size at age 10	0.4	2.0	11.1	-0.7	-0.8	1.2	0.4	-0.5	-3.3	0.2
Number of full sisters	0.5	0.6	3.3	-0.1	1.8	0.1	0.0	1.0	-0.4	0.0
Suffer from ‘nerves’	0.5	0.8	1.9	1.1	-0.5	1.0	0.5	-0.5	-0.7	1.4
Overall health rating	1.7	3.6	7.4	-0.3	-2.5	-2.0	-2.7	-0.7	2.2	1.5
Chest pain or discomfort	1.3	1.8	4.2	-1.6	0.4	-2.1	-1.7	1.6	0.2	-0.6
Had major operations	1.0	1.2	4.0	-1.7	-0.3	1.0	0.2	0.2	0.3	-2.0
Age at last live birth	0.4	0.6	1.9	0.3	0.6	0.5	1.4	-0.2	0.1	-1.2
Family relationship satisfaction	0.6	0.8	2.4	0.6	0.3	0.7	0.5	-0.5	-1.2	1.6
Leg pain on walking	0.5	0.7	1.2	-0.1	-0.6	-1.1	-0.7	-0.9	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.6	0.9	0.7	-0.5	-1.3	-2.4	0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	0.6	0.1	-0.8	-0.0	-1.0	-1.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	1.0	-0.6	1.0	0.7	-0.6	-0.1	0.4
Medication: Aspirin	0.5	0.7	1.8	-1.3	-1.0	-0.4	-1.1	0.0	-0.7	-0.1
Supplements: Vitamin C	0.6	0.7	1.9	-1.4	0.3	0.8	1.0	0.9	-0.4	-0.6
Knee pain experienced in last month	1.0	1.5	4.6	-2.1	-1.1	-1.2	-1.5	0.5	0.8	0.2
Hypertension (Self-reported)	0.3	0.7	2.9	0.9	0.6	-0.3	-0.4	-0.5	0.8	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	7.2	-2.7	-0.0	-0.9	-1.5	2.0	-0.1	0.1
Illnesses of father: Heart disease	1.5	2.1	4.9	-2.2	-1.3	-1.7	-1.8	1.0	0.6	0.9
Illnesses of siblings: Diabetes	0.9	1.1	3.7	0.7	-0.3	-0.2	-1.0	-1.0	1.9	1.2
Smoking status: Previous	2.3	3.4	11.1	2.0	1.5	3.3	2.5	-0.7	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.8	0.8	-1.5	0.8	-0.6	-2.2	-0.9	-0.1
Whole body fat-free mass	0.3	1.6	4.2	1.2	-0.7	-0.5	-0.2	-0.9	-2.0	-2.0
Leg fat-free mass (right)	0.4	2.1	6.2	1.7	-1.2	-1.2	-0.3	-1.3	-0.9	-2.5
Arm fat percentage (left)	1.3	5.2	11.4	0.4	-2.7	-3.3	-3.4	-1.6	1.2	-1.4
Average weekly red wine intake	2.3	3.4	8.9	-0.1	-1.1	3.0	3.0	-0.2	-0.7	-2.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	-0.6	-0.4	-1.1	0.4	0.9	-0.5	0.1
Mood swings	0.7	1.3	4.0	-1.2	-1.4	0.0	-0.8	-0.3	2.0	-1.0
Loneliness, isolation	0.8	1.1	4.0	-0.3	0.7	0.0	-1.6	0.5	-0.5	2.0
Long-standing illness, disability or infirmity	1.9	3.0	8.3	-0.6	-1.5	-2.1	-2.3	-0.4	2.9	0.3
Ever had bowel cancer screening	0.4	0.4	2.0	-1.4	0.0	0.6	-0.2	0.6	0.3	0.4
Diabetes diagnosed by doctor	1.5	2.5	4.6	1.6	-0.8	-2.1	-1.9	-1.2	1.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.4	1.4	0.3	-0.7	0.2	-1.8	0.3	0.9
Friendships satisfaction	0.8	1.0	2.4	1.6	0.2	1.2	0.8	-1.4	-0.5	0.4
Qualifications: nursing, teaching	0.5	0.8	3.2	-1.1	-0.3	0.5	-0.0	0.8	0.2	-1.8
Commuting to job workplace: Walk	2.4	2.6	6.9	-1.6	1.5	0.6	1.3	2.6	-1.5	-1.4
Eye problems/disorders: Cataract	0.4	0.4	1.1	-0.3	0.3	0.8	1.0	-0.8	0.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.5	0.1	-2.1	-0.1	-1.0	-0.1	0.8	1.0
Medication for cholesterol	0.6	0.9	1.6	1.1	0.3	0.6	0.8	-0.6	-1.3	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.3	-0.8	-0.1	-1.0	-0.8	0.7	1.1
Back pain experienced in last month	0.5	0.7	3.8	0.6	-0.9	0.5	-0.1	-2.0	0.2	-0.0
Mineral and other dietary supplements	1.2	1.6	4.0	1.6	0.9	-0.8	-1.7	-0.5	-0.3	2.0
Breast cancer (self-reported)	0.5	0.6	1.9	0.4	0.1	1.4	0.8	-0.2	-0.7	-1.0
Asthma (self-reported)	1.0	1.9	5.9	2.4	1.2	1.1	1.2	-0.8	0.7	1.6
Osteoporosis (self-reported)	0.9	1.1	3.6	-0.2	-0.4	-1.5	-1.3	-0.6	1.9	0.1
Osteoarthritis (self-reported)	1.8	2.3	6.4	-1.4	-1.4	-2.5	-1.9	-0.2	1.3	-0.5
Medication: Aspirin	0.2	0.3	1.1	-1.0	-0.7	0.0	-0.8	-0.2	-0.2	-0.1
Medication: Gliclazide	1.6	1.8	3.9	0.1	-1.2	-2.0	-1.4	-0.8	2.0	-0.7
Illnesses of father: None of the above (group 1)	1.3	1.6	6.7	0.1	0.1	1.4	1.6	-0.1	-0.5	-2.6
Smoking status: Current	2.5	4.0	8.3	2.9	0.5	1.6	0.5	-2.0	-2.6	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.4	9.3	23.6	-3.6	0.5	1.8	0.8	4.5	-4.9	-2.0
Whole body water mass	0.3	1.6	4.5	1.2	-0.8	-0.5	-0.2	-0.8	-2.0	-2.1
Leg predicted mass (right)	0.4	2.1	6.2	1.7	-1.3	-1.2	-0.3	-1.3	-0.9	-2.5
Arm fat mass (left)	0.9	3.9	9.5	0.8	-2.3	-2.9	-3.1	-1.2	0.5	-1.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-1.1	-0.6	-0.9	-0.2	0.7	1.3	-0.2
Average weekly champagne plus white wine intake	1.7	2.3	7.8	-2.8	-1.6	-0.6	-1.7	0.5	-0.8	-1.2
Miserableness	0.1	0.2	0.9	-0.0	-0.5	-0.3	-0.3	-1.0	-0.2	-0.0
Guilty feelings	1.7	2.5	6.3	-2.5	-2.4	-0.7	-1.4	-0.1	1.7	0.3
Wears glasses or contact lenses	0.9	1.1	2.2	-1.5	-0.6	0.9	1.2	1.3	1.0	-0.4
Ever taken oral contraceptive pill	0.4	0.4	1.6	0.3	-0.3	0.4	0.7	-1.2	0.8	-0.2
Hearing aid user	1.0	1.1	3.0	-0.1	-1.3	0.4	0.2	-1.1	-1.2	1.7
Mother’s age at death	0.9	1.1	2.5	-1.6	-1.1	-0.9	0.4	1.1	0.7	-1.2
Financial situation satisfaction	0.5	0.6	1.7	0.4	-0.1	0.7	1.3	0.5	0.8	0.9
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.4	-0.7	-1.3	-1.7	-0.9	-0.1	0.9	-1.9
Commuting to job workplace: Public transport	1.9	2.3	7.8	-2.2	-0.9	-0.3	-0.3	1.1	1.0	-2.8
Eye problems/disorders: Glaucoma	0.9	1.0	2.6	-1.0	-1.5	-0.7	-1.6	-0.3	1.0	-0.1
Medication: Blood pressure	0.0	0.1	0.3	0.5	0.2	-0.3	-0.2	-0.0	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.5	-1.9	-1.1	-0.7	-1.4	0.6	0.9	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.4	4.7	-0.9	0.4	0.7	2.2	0.6	-0.4	-1.7
High cholesterol (Self-reported)	0.5	0.8	3.3	-1.3	-1.8	0.1	-0.3	0.3	0.1	-0.7
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.1	-0.1	-0.6	-0.8	0.0	-0.6	0.4
Medication: Paracetamol	0.8	1.2	4.0	0.6	-2.0	0.7	0.1	-1.7	0.6	-0.7
Medication: Lisinopril	0.5	0.6	1.2	-0.8	-1.1	-0.1	-1.0	-1.0	0.1	0.6
Medication: Atorvastatin	1.2	1.4	4.5	-0.5	-0.9	-1.3	-0.8	-0.4	2.1	-1.4
Illnesses of father: High blood pressure	1.2	1.5	5.0	2.2	1.6	-0.2	0.3	-0.9	0.7	1.1
Alcohol drinker status: Never	2.3	2.8	9.3	-1.2	-1.8	-3.0	-1.7	0.7	1.1	-1.0
Ever smoked	1.6	2.9	9.7	1.8	1.3	3.1	2.2	0.1	-0.9	0.3
Basal metabolic rate	0.4	1.9	3.8	1.1	-1.4	-1.3	-1.1	-1.1	-1.7	-1.9
Leg fat percentage (left)	1.5	5.4	20.7	0.1	-2.0	-3.4	-4.5	-0.9	0.4	0.5
Arm fat-free mass (left)	0.2	1.3	3.3	1.0	-0.8	-0.7	-1.1	-0.4	-1.8	-1.4
Number of operations (self-reported)	1.4	2.1	5.8	-2.3	-1.0	-0.2	-1.0	0.9	1.0	-2.4
Average weekly beer plus cider intake	2.0	2.9	14.4	3.8	1.3	0.2	1.2	-1.4	-0.2	1.0
Irritability	1.0	1.7	6.0	1.5	-1.0	1.3	1.0	-2.4	0.3	0.4
Risk taking	0.5	0.8	3.4	0.5	0.6	-0.5	-0.3	-0.1	1.0	-1.8
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.7	-2.2	0.4	1.7	1.0	1.0	-2.0	-0.7
Fractured/broken bones in last 5 years	0.4	0.5	2.5	-0.6	-1.6	0.0	-0.4	0.1	-0.8	0.1
Age started oral contraceptive pill	0.6	0.7	3.0	-0.9	-0.3	-0.1	-0.5	1.7	0.1	0.9
Diastolic blood pressure, automated reading	1.8	5.7	21.2	4.6	1.1	0.2	0.5	-3.0	-0.2	2.8
Ever depressed for a whole week	1.0	1.2	2.7	0.4	-1.6	-0.8	-0.7	-1.4	1.5	0.4
Unable to work because of sickness or disability	0.6	0.8	2.6	-0.3	-0.4	-0.5	-1.5	0.2	-0.1	1.6
Commuting to job workplace: Cycle	0.5	0.6	1.7	0.8	0.9	0.9	0.4	-0.4	0.3	-1.3
Myopia	1.4	2.0	4.3	-2.0	0.3	0.2	0.1	2.1	-1.8	-1.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.4	-0.1	-0.6	0.6	1.0	0.2	-1.2	-1.6
Cholesterol lowering medication	1.6	2.3	4.2	-1.5	-1.5	-1.0	-1.7	0.8	2.1	-1.8
Medication: Omeprazole (e.g. Zanprol)	2.3	2.9	8.0	-2.8	-1.8	-1.0	-1.9	1.6	0.5	1.1
Pain experienced in last month	0.7	1.2	5.4	-0.3	0.7	-0.4	-0.1	1.5	-2.3	0.2
Supplements: Calcium	2.1	2.3	8.0	-2.8	-1.6	0.6	-0.4	1.3	0.7	-1.8
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	-0.1	-0.5	-1.1	0.0	-0.9	0.8	-1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.8	-2.2	0.6	0.4	-0.3	1.0	-0.5	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.3	-0.9	-1.8	-1.3	-1.5	-1.1	0.1	-0.7
Heart disease (siblings)	1.3	1.6	4.3	-2.1	-0.9	-0.5	-0.8	1.1	1.9	-0.5
Alcohol drinker status: Previous	2.4	2.7	8.4	0.9	-2.9	-0.2	-1.4	-2.7	-0.6	0.2
Pack years of smoking	1.1	1.6	3.1	0.5	-0.3	-1.8	-1.7	-1.4	-1.2	1.1
Impedance of whole body	0.9	4.3	8.2	-2.9	-2.8	-0.5	-2.5	-0.9	0.2	2.6
Leg fat mass (left)	1.1	4.5	14.7	0.9	-1.8	-3.2	-3.8	-1.5	0.2	-0.6
Arm predicted mass (left)	0.2	1.2	2.8	1.0	-0.9	-0.9	-1.1	-0.6	-1.7	-1.3