Hub : Genes

FSD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1045 0.0461 1.0e-03 0.033 NA 0.079 NA 0.052 0.00130 NA 1.1e-06 NA 8.0e-05
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0727 0.0290 4.4e-07 0.024 0.05 0.035 NA 0.041 0.00096 2.7e-06 6.9e-05 NA 2.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.2 -0.5 0.1
Bipolar Disorder or Schizophrenia 0.2 0.4 0.7 -0.3 -0.8
Depressed Affect (Nagel 2018) 0.5 1.0 1.8 0.5 -1.3
Depression (Nagel 2018) 1.5 2.3 4.5 0.2 -2.1
Intelligence (Savage-Jansen 2018) 1.0 3.0 4.3 2.1 1.3
Neuroticism (Nagel 2018) 0.2 0.4 0.6 0.5 -0.8
Schizophrenia (2018) 0.3 0.7 1.2 -0.4 -1.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.3 -0.6 0.5
Worry (Nagel 2018) 0.2 0.4 0.5 -0.6 0.7
Alzheimer’s Disease (in mother) 0.9 1.0 1.9 0.3 -1.4
Alzheimer’s Disease (in father) 1.7 1.9 3.5 -0.4 -1.9
Alzheimer’s Disease (including proxy) 0.9 1.4 1.9 -0.9 -1.4
Crohns Disease (2017) 0.9 1.9 2.4 1.6 -1.2
Irritable Bowel Disease (IBD) 0.6 1.5 1.7 1.3 -1.1
Ulcerative Colitis (UC) 0.2 0.3 0.6 0.2 -0.7
Major Depression (MDD) 0.5 0.6 0.9 -0.4 -1.0
Reaction Time 0.2 0.4 0.4 0.6 -0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.4 0.7 0.4
Breast Cancer 0.8 2.0 3.3 -0.9 1.8
Ovarian Cancer 0.1 0.2 0.2 -0.4 -0.4
Prostate Cancer 0.3 0.4 0.5 -0.7 0.4
Age at First Birth 1.0 1.5 2.3 0.8 1.5
Bipolar Disorder (2011) 1.1 1.1 1.8 0.6 -1.3
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 -0.0 0.9
Coronary Artery Disease (CAD) 1.1 1.4 2.1 -0.8 -1.5
Crohns Disease (2012) 1.0 1.6 2.2 0.9 -1.5
Mean Putamen Volume 0.3 0.3 0.6 -0.8 0.1
Fasting Glucose 0.3 0.4 0.5 -0.7 -0.5
HbA1C 0.1 0.1 0.3 0.5 0.2
HDL Cholesterol 0.0 0.1 0.1 -0.3 -0.2
LDL Cholesterol 0.2 0.3 0.6 -0.2 0.7
Lupus 0.7 1.1 1.4 1.2 -0.9
Neuroticism (2016) 0.2 0.3 0.6 -0.3 0.8
Primary Biliary Cirrhosis 0.0 0.0 0.0 -0.2 0.1
Rheumatoid Arthritis 1.8 2.5 4.5 2.1 -0.8
Schizophrenia (2014) 0.3 0.6 1.1 0.1 -1.1
Triglycerides 0.4 0.7 0.9 0.7 1.0
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.4 0.1 -1.8
Ulcerative Colitis 0.0 0.1 0.1 0.1 -0.3
Blood Eosinophil Count 0.1 1.1 1.8 0.6 -1.4
Blood Platelet Count 0.6 7.4 13.7 1.0 -3.7
Blood Red Count 0.1 1.1 1.9 -1.4 0.5
Blood White Count 0.1 0.5 0.6 0.7 -0.7
Heel T-Score 1.4 11.5 14.2 3.8 -3.0
BMI 0.1 0.7 1.0 -0.6 -1.0
Height 0.1 2.4 2.6 -1.6 -1.5
Waist Hip Ratio (WHR) 0.7 3.0 5.2 2.3 -0.9
Systolic Blood Pressure 0.6 3.2 4.0 -1.5 2.0
Smoking Status 1.2 2.9 5.5 -2.3 0.6
Allergy or Eczema 0.3 0.9 0.9 -1.0 0.9
Cardiovascular Disease 0.0 0.1 0.2 -0.2 -0.4
Hypothyroidism (self reported) 0.2 0.4 0.6 0.8 0.3
Respiratory disease 0.1 0.1 0.2 0.5 -0.1
Type 2 Diabetes (T2D) (2018) 1.8 3.3 4.3 -2.1 -1.5
Lung FEV1/FVC ratio 0.7 3.6 7.0 0.3 2.6
Lung FVC 3.3 16.7 32.2 1.1 5.7
Neuroticism 0.0 0.0 0.0 0.0 -0.1
Chronotype (morning person) 0.1 0.3 0.5 0.7 -0.1
Hair Pigment 0.5 14.1 25.1 5.0 1.8
Tanning 0.2 2.5 4.1 1.0 -2.0
Hand grip strength (left) 2.6 6.9 12.3 -1.2 3.5
Number of treatments/medications taken 0.4 0.7 1.4 1.2 -0.3
Average weekly spirits intake 2.3 2.9 3.6 -1.5 1.9
Sensitivity / hurt feelings 0.0 0.0 0.1 0.1 -0.3
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.0 -0.6 -1.4
Hearing difficulty/problems: Yes 0.2 0.4 0.7 -0.8 -0.1
Relative age of first facial hair 1.1 2.3 3.9 0.8 2.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 0.8 -0.8 0.9
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.9 0.9 -0.6
Ever had hysterectomy (womb removed) 2.1 2.4 3.4 1.8 -1.1
Systolic blood pressure, automated reading 0.7 2.0 2.8 -1.7 1.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 -0.6 0.1
Angina 2.0 2.6 2.7 1.6 -1.6
Medication for hormone replacement therapy 0.3 0.3 0.4 0.6 0.5
Vitamin and mineral supplements 1.9 2.5 2.9 -1.7 -1.4
Supplements: Zinc 2.8 3.1 3.4 1.6 1.9
Medication: Co-codamol 4.4 5.1 8.2 1.4 -2.9
Medication: Metformin 2.3 3.2 3.6 -1.7 -1.9
Diabetes (father) 2.1 2.6 3.5 -1.9 -1.3
Diabetes (mother) 0.7 0.8 1.7 0.1 -1.3
Severe depression (siblings) 0.3 0.3 0.6 -0.7 0.1
Pack years adult smoking proportion 3.0 4.5 6.5 -2.5 -1.6
Impedance of leg (right) 0.1 0.5 0.7 -0.6 -0.8
Leg fat-free mass (left) 0.3 1.4 2.0 -1.4 -0.9
Trunk fat percentage 1.7 7.0 13.5 -0.7 -3.7
Hand grip strength (right) 0.6 1.8 1.8 -1.3 1.4
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.2 -0.4
Current tobacco smoking 1.5 2.4 4.7 -2.2 -0.3
Average weekly fortified wine intake 0.5 0.6 1.1 0.1 1.1
Maternal smoking around birth 0.7 1.0 1.3 -0.8 -1.1
Fed-up feelings 0.4 0.7 1.5 0.2 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.6 5.2 -0.3 -2.3
Relative age voice broke 0.7 1.1 2.1 0.4 1.4
Taking other prescription medications 0.2 0.2 0.5 0.7 -0.0
Age when periods started (menarche) 0.7 1.6 2.8 -1.7 0.6
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 1.8 1.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 6.5 1.7 -2.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.4 -0.6 -0.3
Qualifications: CSEs or equivalent 1.5 2.0 3.4 -0.7 -1.8
Serious illness, injury or assault to yourself 0.0 0.0 0.0 0.2 0.0
High blood pressure 0.5 1.5 2.9 -0.3 -1.7
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.1 -1.1 0.9
Multivitamins +/- minerals 2.6 3.4 6.6 2.6 0.3
Stomach or abdominal pain in last month 1.1 1.4 2.1 0.9 1.4
Supplements: Glucosamine 1.4 1.9 3.7 1.9 0.2
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 2.9 1.7 -0.4
Medication: Atenolol 2.5 3.1 3.1 -1.8 1.8
Medication: Levothyroxine sodium 0.3 0.5 0.5 0.7 0.7
Sitting height 0.5 3.2 6.5 -2.5 0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 -0.3 -0.6
High blood pressure (mother) 0.6 0.8 1.6 -1.3 0.3
Body mass index (BMI) 1.1 4.7 9.1 -0.5 -3.0
Impedance of leg (left) 0.1 0.5 0.5 -0.7 -0.7
Leg predicted mass (left) 0.3 1.4 2.0 -1.4 -0.8
Trunk fat mass 1.4 6.0 10.6 -1.2 -3.3
Waist circumference 1.5 5.7 11.3 -0.2 -3.4
Number of incorrect matches in round 1.0 1.6 2.0 1.1 1.4
Past tobacco smoking 0.4 0.7 1.4 0.0 -1.2
Alcohol usually taken with meals 2.8 4.5 4.8 2.2 2.1
Nervous feelings 3.2 6.0 7.6 -2.1 2.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.3 -0.0 -1.2
Hearing difficulty/problems with background noise 0.8 1.3 2.2 -1.5 0.5
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 0.9 0.1
Had menopause 0.0 0.1 0.1 0.3 0.0
Had other major operations 4.2 5.1 7.9 2.8 -1.5
Forced vital capacity (FVC) 2.1 7.9 15.9 -0.0 4.0
Heel bone mineral density (BMD) T-score, automated (right) 2.2 4.9 6.4 1.9 -2.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.5 0.1 -0.7
Qualifications: None of the above 2.7 5.9 11.6 0.4 -3.4
Financial difficulties in last 2 years 0.7 0.9 1.3 1.1 -0.7
Mouth/teeth dental problems 0.1 0.1 0.2 -0.4 0.2
Heart attack 0.9 1.2 2.2 1.5 0.5
Allergy 0.0 0.1 0.1 -0.4 0.1
Pain all over the body in last month 2.7 2.9 4.4 1.2 -2.1
Diabetes (self-reported) 2.2 3.3 4.9 -2.2 -1.3
Hayfever/allergic rhinitis (self-reported) 0.0 0.1 0.1 0.1 -0.3
Medication: Ramipril 0.5 0.6 0.6 -0.8 0.8
Medication: Simvastatin 0.1 0.2 0.3 0.3 0.5
Fluid intelligence score 0.1 0.3 0.5 0.7 0.2
Illnesses of siblings 3.4 4.8 8.9 -0.8 3.0
Neuroticism score 0.1 0.3 0.5 0.2 0.7
Weight 0.8 4.1 5.7 -1.6 -2.4
Impedance of arm (right) 0.1 0.4 0.5 0.7 0.6
Arm fat percentage (right) 1.2 4.8 9.7 -0.1 -3.1
Trunk fat-free mass 0.3 2.0 3.6 -1.9 0.6
Hip circumference 0.9 3.7 4.6 -1.7 -2.2
Time employed in main current job 2.9 3.4 4.9 2.2 -1.4
Alcohol intake versus 10 years previously 1.1 1.6 2.3 0.9 -1.5
Father’s age at death 1.1 1.4 2.8 1.7 -0.0
Worrier / anxious feelings 0.5 1.0 1.4 0.8 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 0.4 -0.9
Falls in the last year 0.0 0.0 0.1 -0.0 -0.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 -0.6 0.4
Number of live births 3.0 4.3 8.1 -0.7 -2.8
Forced expiratory volume in 1-second (FEV1) 3.0 10.1 20.1 0.4 4.5
Pulse rate 1.0 1.8 1.9 -1.4 -1.3
Happiness 2.1 2.6 3.9 -2.0 1.1
Noisy workplace 0.8 0.9 1.9 0.0 -1.4
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.5 0.9 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 0.9 -1.0 0.5
Mouth/teeth dental problems: Dentures 0.6 1.0 1.3 0.8 -1.1
Asthma 0.2 0.4 0.8 0.9 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.8 -0.7 1.3
Medication: Cholesterol lowering 0.0 0.0 0.0 -0.2 -0.2
Depression (self-reported) 0.5 0.6 0.9 1.0 0.6
Medication: Lansoprazole 0.5 0.6 1.1 1.1 -0.3
Prospective memory result 0.9 1.1 1.5 -0.8 -1.2
Lung cancer (father) 1.6 1.8 3.7 0.1 -1.9
Illnesses of mother 1.0 1.2 2.4 1.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.8 12.2 24.0 -0.7 4.9
Pulse wave Arterial Stiffness index 0.0 0.1 0.1 0.3 -0.2
Impedance of arm (left) 0.0 0.1 0.1 0.3 0.2
Arm fat mass (right) 1.1 4.6 8.7 -0.8 -2.9
Trunk predicted mass 0.4 2.1 3.7 -1.9 0.7
Standing height 0.4 3.8 6.2 -2.5 1.2
Length of working week for main job 0.2 0.2 0.5 -0.0 -0.7
Exposure to tobacco smoke at home 0.3 0.4 0.7 -0.8 -0.2
Breastfed as a baby 1.8 2.3 4.5 2.1 -0.1
Tense / ‘highly strung’ 1.0 1.6 3.1 -0.3 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.5 -0.7 -1.2
Hair/balding pattern: Pattern 4 1.1 2.8 5.2 0.6 -2.3
Birth weight of first child 0.0 0.0 0.0 -0.1 -0.2
Peak expiratory flow (PEF) 2.9 6.8 7.4 2.7 2.5
Pulse wave reflection index 0.5 0.6 1.2 -0.2 1.1
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.1 0.6 -1.4
Loud music exposure frequency 0.7 0.8 1.4 -1.2 -0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.3 1.0 1.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.5 -0.6 0.7
Blood clot in the leg (DVT) 0.2 0.3 0.5 0.1 -0.7
Medication: Paracetamol 0.2 0.3 0.3 0.6 0.4
Headache pain in last month 0.4 0.7 1.1 0.5 1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.2 1.1 0.3
Glaucoma (self-reported) 0.5 0.6 0.9 0.5 -1.0
Gout (self-reported) 0.7 0.9 1.5 1.2 -0.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 0.8 0.6 0.9
Medication: Amlodipine 0.3 0.4 0.6 -0.8 0.4
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.2 -1.1 0.8
Birth weight 0.8 1.8 3.4 -0.5 1.8
Chronic bronchitis/emphysema (mother) 3.0 3.5 5.7 -2.4 1.2
High blood pressure (siblings) 1.7 2.4 4.1 -0.8 -2.0
Forced vital capacity (FVC), Best measure 2.9 10.6 20.2 -0.9 4.5
Body fat percentage 1.9 7.5 14.4 -0.8 -3.8
Leg fat percentage (right) 2.4 8.6 16.3 -0.9 -4.0
Arm fat-free mass (right) 0.4 2.0 3.3 -1.8 -0.9
Exposure to tobacco smoke outside home 0.3 0.4 0.8 -0.9 -0.1
Comparative body size at age 10 0.8 2.1 3.4 -0.9 -1.8
Number of full brothers 1.0 1.2 1.6 1.2 -0.9
Worry too long after embarrassment 0.9 1.5 1.6 1.2 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.5 -0.6 -0.7
Wheeze or whistling in the chest in last year 1.5 2.7 4.9 -0.7 -2.2
Number of children fathered 0.5 0.5 1.0 -1.0 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 0.3 1.0
Age at first live birth 0.4 0.7 1.0 0.6 1.0
Pulse wave peak to peak time 0.2 0.3 0.4 -0.6 0.4
Health satisfaction 0.2 0.3 0.3 -0.6 0.5
Shortness of breath walking on level ground 2.4 2.8 5.0 2.2 -0.8
Qualifications: College or University degree 1.2 3.8 7.6 0.2 2.8
Eye problems/disorders: None of the above 0.3 0.4 0.8 -0.9 0.0
Mouth/teeth dental problems: Loose teeth 0.8 1.0 1.7 -1.3 -0.6
Emphysema/chronic bronchitis 2.0 2.2 2.4 1.5 -1.4
Medication for pain relief, constipation, heartburn 0.3 0.6 1.2 -1.1 -0.1
Neck or shoulder pain in last month 0.2 0.3 0.4 0.7 0.3
Medication: Blood pressure 0.7 1.3 2.5 -1.6 -0.1
Angina (self-reported) 1.6 2.1 2.7 1.2 -1.6
Migraine (self-reported) 2.2 2.7 4.5 2.1 0.9
Medication: Ibuprofen 1.5 1.7 3.5 -0.1 1.9
Medication: Allopurinol 0.1 0.2 0.3 0.6 0.2
Medication: Omeprazole 0.0 0.0 0.1 0.2 0.1
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.4 -0.7
Mean time to correctly identify matches 0.7 1.3 1.5 1.1 -1.2
Heart disease (mother) 0.0 0.0 0.0 -0.2 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.9 0.9 -0.5
Whole body fat mass 1.6 6.7 11.9 -1.2 -3.5
Leg fat mass (right) 2.2 8.6 15.5 -1.3 -3.9
Arm predicted mass (right) 0.5 2.4 4.4 -2.1 -0.6
Pulse rate, automated reading 1.9 6.2 6.9 -2.4 -2.6
Alcohol intake frequency. 2.0 4.7 7.0 -1.5 -2.6
Comparative height size at age 10 0.1 0.4 0.4 -0.6 -0.7
Number of full sisters 0.1 0.1 0.2 0.2 -0.4
Suffer from ‘nerves’ 1.0 1.6 2.6 -0.7 1.6
Overall health rating 0.6 1.3 2.5 0.3 -1.6
Chest pain or discomfort 0.0 0.0 0.0 -0.2 0.1
Had major operations 1.7 2.0 3.1 1.8 0.9
Age at last live birth 0.4 0.6 0.8 0.7 0.9
Family relationship satisfaction 0.5 0.6 1.1 -1.1 0.3
Leg pain on walking 1.3 1.6 2.7 0.7 -1.6
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 4.9 -0.6 -2.2
Commuting to job workplace: Car/motor vehicle 1.3 1.5 1.7 -1.2 -1.3
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.0 0.4 1.0
Medication: Aspirin 0.3 0.4 0.7 -0.1 0.8
Supplements: Vitamin C 1.9 2.2 4.3 -0.3 2.1
Knee pain experienced in last month 0.0 0.0 0.0 0.2 -0.1
Hypertension (Self-reported) 0.6 1.6 2.9 -0.6 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.4 0.5 -0.7
Illnesses of father: Heart disease 1.0 1.3 1.8 0.9 -1.3
Illnesses of siblings: Diabetes 4.5 5.6 8.9 1.5 -3.0
Smoking status: Previous 0.5 0.8 1.3 0.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.6 -0.3
Whole body fat-free mass 0.3 1.7 3.5 -1.9 0.0
Leg fat-free mass (right) 0.2 1.0 1.8 -1.3 -0.5
Arm fat percentage (left) 1.2 4.8 9.5 -0.3 -3.1
Average weekly red wine intake 3.8 5.6 10.1 1.0 3.2
Handedness (chirality/laterality): Left-handed 3.2 3.9 7.6 -0.3 2.8
Mood swings 0.9 1.5 3.0 1.7 -0.3
Loneliness, isolation 0.9 1.3 1.5 -1.2 -1.1
Long-standing illness, disability or infirmity 0.9 1.4 2.5 0.6 -1.6
Ever had bowel cancer screening 1.4 1.6 2.6 1.6 -0.8
Diabetes diagnosed by doctor 2.1 3.4 3.4 -1.8 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.8 -1.4 -0.0
Friendships satisfaction 1.5 1.9 3.5 -1.9 0.5
Qualifications: nursing, teaching 0.1 0.2 0.3 0.2 0.6
Commuting to job workplace: Walk 3.3 3.5 6.5 0.7 2.6
Eye problems/disorders: Cataract 0.6 0.7 1.4 1.2 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.6 0.1
Medication for cholesterol 1.9 2.9 3.3 -1.8 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.3 -0.3 -1.5
Back pain experienced in last month 0.2 0.3 0.3 -0.6 -0.5
Mineral and other dietary supplements 3.1 4.1 6.7 -1.2 -2.6
Breast cancer (self-reported) 0.9 1.0 2.0 -0.1 1.4
Asthma (self-reported) 0.2 0.4 0.5 0.7 -0.5
Osteoporosis (self-reported) 1.5 1.9 2.2 1.3 -1.5
Osteoarthritis (self-reported) 0.2 0.3 0.4 0.4 -0.6
Medication: Aspirin 0.1 0.1 0.2 -0.1 0.4
Medication: Gliclazide 0.2 0.2 0.5 0.1 -0.7
Illnesses of father: None of the above (group 1) 2.2 2.8 5.5 0.2 2.3
Smoking status: Current 2.2 3.5 6.9 -2.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.4 11.5 22.8 0.5 4.8
Whole body water mass 0.3 1.5 3.1 -1.7 -0.0
Leg predicted mass (right) 0.2 1.0 1.7 -1.3 -0.5
Arm fat mass (left) 1.2 4.8 9.2 -0.6 -3.0
Number of self-reported non-cancer illnesses 0.7 1.1 1.8 1.3 -0.7
Average weekly champagne plus white wine intake 0.4 0.6 1.1 1.1 0.1
Miserableness 0.3 0.5 0.8 -0.9 0.5
Guilty feelings 0.7 1.1 2.1 1.5 0.1
Wears glasses or contact lenses 1.5 1.8 2.5 1.6 1.0
Ever taken oral contraceptive pill 0.1 0.1 0.3 0.5 -0.0
Hearing aid user 1.0 1.2 2.3 -0.2 1.5
Mother’s age at death 0.1 0.1 0.2 -0.5 -0.1
Financial situation satisfaction 0.4 0.5 0.8 0.9 0.4
Tinnitus: Yes, now most or all of the time 1.3 1.6 2.3 1.5 -0.9
Commuting to job workplace: Public transport 0.8 0.9 1.3 0.8 1.1
Eye problems/disorders: Glaucoma 0.9 1.1 2.1 0.3 -1.4
Medication: Blood pressure 0.5 0.9 1.8 -0.2 -1.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.3 -0.6
Supplements: Fish oil (including cod liver oil) 2.7 3.5 6.7 0.5 2.6
High cholesterol (Self-reported) 0.7 1.2 1.8 0.8 1.3
Medication: Bendroflumethiazide 0.6 0.9 1.7 -1.3 -0.2
Medication: Paracetamol 0.1 0.2 0.3 0.1 0.6
Medication: Lisinopril 1.1 1.4 2.8 -0.2 -1.7
Medication: Atorvastatin 0.4 0.5 0.7 0.8 -0.6
Illnesses of father: High blood pressure 1.3 1.6 3.1 -0.3 -1.8
Alcohol drinker status: Never 0.7 0.9 1.1 -0.8 -1.1
Ever smoked 0.5 0.9 1.5 0.5 1.2
Basal metabolic rate 0.4 2.0 3.4 -1.8 -0.7
Leg fat percentage (left) 2.2 8.0 14.9 -1.0 -3.9
Arm fat-free mass (left) 0.3 1.7 2.7 -1.7 -0.8
Number of operations (self-reported) 0.7 1.1 1.8 1.4 -0.5
Average weekly beer plus cider intake 1.0 1.4 2.7 -1.6 -0.4
Irritability 0.2 0.3 0.4 0.6 0.5
Risk taking 0.1 0.1 0.2 -0.0 -0.4
Ever had prostate specific antigen (PSA) test 1.6 1.9 2.8 1.0 1.7
Fractured/broken bones in last 5 years 0.3 0.4 0.7 -0.3 0.9
Age started oral contraceptive pill 0.5 0.6 1.1 0.2 1.1
Diastolic blood pressure, automated reading 1.5 4.6 8.2 -2.9 -1.0
Ever depressed for a whole week 1.0 1.3 2.0 0.7 -1.4
Unable to work because of sickness or disability 0.6 0.8 1.2 -0.6 -1.1
Commuting to job workplace: Cycle 0.4 0.5 0.8 -0.5 0.9
Myopia 1.1 1.5 3.1 0.0 1.8
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.1 0.2 1.8
Cholesterol lowering medication 2.4 3.5 5.8 2.4 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.4 -0.2
Pain experienced in last month 0.7 1.2 1.8 -1.3 0.8
Supplements: Calcium 0.8 0.9 1.5 1.2 0.5
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 0.7 0.3
Heart attack/myocardial infarction (self-reported) 1.0 1.2 2.1 1.5 0.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 0.0 -0.9
Heart disease (siblings) 3.1 3.7 5.0 2.2 -1.6
Alcohol drinker status: Previous 0.6 0.7 1.3 -1.1 -0.2
Pack years of smoking 2.7 4.0 4.7 -2.2 -1.8
Impedance of whole body 0.0 0.0 0.0 -0.1 -0.2
Leg fat mass (left) 2.1 8.0 14.6 -1.2 -3.8
Arm predicted mass (left) 0.3 1.8 2.7 -1.6 -0.9