[Hub]/) : Traits : Lung FVC : ← →

chr19:288,246-2,923,263

Best TWAS P=4.63e-11 · Best GWAS P=1.12e-09 conditioned to 0.429

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	WDR18	0.50	0.43	enet	16	0.55	1.7e-33	6.1	5.4	6.8e-08	0.86	0.00	1.00	FALSE
2	GTEx	Adrenal Gland	WDR18	0.57	0.18	lasso	8	0.32	2.7e-12	6.1	5.4	6.5e-08	0.90	0.00	1.00	FALSE
3	GTEx	Artery Aorta	WDR18	0.54	0.53	lasso	7	0.66	1.9e-47	6.1	5.5	3.8e-08	0.90	0.00	1.00	FALSE
4	GTEx	Artery Coronary	WDR18	0.74	0.47	lasso	11	0.56	2.6e-22	6.1	5.7	9.6e-09	0.93	0.00	1.00	FALSE
5	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	-5.6	-5.2	1.9e-07	0.01	0.02	0.98	FALSE
6	GTEx	Brain Hippocampus	WDR18	0.47	0.16	enet	34	0.20	2.3e-05	6.1	5.2	2.4e-07	0.75	0.00	0.99	FALSE
7	GTEx	Breast Mammary Tissue	WDR18	0.61	0.54	enet	23	0.67	3.7e-45	6.1	5.5	2.9e-08	0.87	0.00	1.00	FALSE
8	GTEx	Colon Sigmoid	WDR18	0.67	0.53	enet	34	0.63	6.4e-28	6.1	5.1	2.9e-07	0.83	0.00	1.00	FALSE
9	GTEx	Colon Transverse	WDR18	0.52	0.45	lasso	6	0.53	3.6e-29	6.1	5.7	1.6e-08	0.92	0.00	1.00	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	WDR18	0.51	0.40	lasso	4	0.60	5.9e-27	6.1	5.3	1.3e-07	0.87	0.00	1.00	FALSE
11	GTEx	Esophagus Muscularis	WDR18	0.62	0.42	lasso	6	0.68	7.6e-56	6.1	5.1	2.7e-07	0.85	0.00	1.00	FALSE
12	GTEx	Heart Left Ventricle	WDR18	0.46	0.47	enet	13	0.56	5.8e-35	6.1	5.6	2.2e-08	0.89	0.00	1.00	FALSE
13	GTEx	Lung	WDR18	0.43	0.39	lasso	4	0.51	6.1e-45	6.1	5.4	7.0e-08	0.87	0.00	1.00	FALSE
14	GTEx	Muscle Skeletal	WDR18	0.47	0.46	lasso	3	0.53	3.6e-61	6.1	5.6	2.1e-08	0.94	0.00	1.00	FALSE
15	GTEx	Ovary	WDR18	0.61	0.57	enet	16	0.61	1.0e-18	6.1	6.1	1.0e-09	0.92	0.00	1.00	FALSE
16	GTEx	Pancreas	WDR18	0.43	0.42	lasso	6	0.47	3.7e-22	6.1	5.8	7.3e-09	0.93	0.00	1.00	FALSE
17	GTEx	Pituitary	WDR18	0.80	0.31	lasso	12	0.47	2.6e-13	6.1	5.5	2.9e-08	0.87	0.00	1.00	FALSE
18	GTEx	Skin Sun Exposed Lower leg	WDR18	0.43	0.44	lasso	4	0.49	1.0e-45	6.1	5.7	1.0e-08	0.94	0.00	1.00	FALSE
19	GTEx	Spleen	ABCA7	0.38	0.16	lasso	5	0.16	5.0e-05	4.1	-5.2	1.8e-07	-0.62	0.01	0.88	FALSE
20	GTEx	Spleen	WDR18	0.44	0.21	lasso	5	0.30	1.6e-08	6.1	6.6	4.6e-11	0.86	0.00	1.00	TRUE
21	GTEx	Stomach	WDR18	0.52	0.40	enet	30	0.44	2.5e-23	6.1	5.2	2.3e-07	0.87	0.00	1.00	FALSE
22	GTEx	Testis	WDR18	0.48	0.46	enet	18	0.54	5.9e-28	6.1	5.4	6.4e-08	0.87	0.00	1.00	FALSE
23	GTEx	Thyroid	WDR18	0.56	0.60	enet	10	0.64	1.7e-62	6.1	5.8	5.8e-09	0.95	0.00	1.00	FALSE
24	GTEx	Uterus	WDR18	0.61	0.52	lasso	4	0.56	6.8e-14	6.1	6.0	1.5e-09	0.96	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	-5.6	-5.7	1.2e-08	0.00	0.01	0.99	TRUE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WDR18	0.23	0.13	lasso	9	0.24	5.3e-14	6.1	5.6	2.0e-08	0.86	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	5.2	-5.7	1.3e-08	-0.02	0.05	0.89	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WDR18	0.38	0.13	lasso	4	0.16	5.5e-07	6.1	6.3	2.4e-10	0.95	0.00	1.00	FALSE