Best TWAS P=1.39e-15 · Best GWAS P=1.77e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CAPS | 0.06 | 0.09 | lasso | 1 | 0.07 | 2.0e-06 | -7.6 | 7.6 | 4.3e-14 | -0.86 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CAPS | 0.16 | 0.11 | lasso | 3 | 0.11 | 6.8e-08 | -7.4 | 7.4 | 1.8e-13 | -0.93 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Mucosa | VMAC | 0.09 | 0.04 | enet | 18 | 0.04 | 7.3e-04 | 4.7 | 5.4 | 5.4e-08 | -0.70 | 0.24 | 0.70 | FALSE |
| 4 | GTEx | Esophagus Mucosa | AC104532.4 | 0.10 | 0.08 | lasso | 6 | 0.06 | 7.8e-05 | -7.4 | 7.4 | 1.7e-13 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Esophagus Muscularis | CAPS | 0.13 | 0.05 | lasso | 3 | 0.04 | 2.9e-03 | -7.5 | 7.3 | 2.8e-13 | -0.96 | 0.02 | 0.92 | FALSE |
| 6 | GTEx | Heart Left Ventricle | VMAC | 0.17 | 0.00 | lasso | 9 | 0.00 | 4.7e-01 | -6.0 | -6.2 | 7.5e-10 | 0.81 | 0.03 | 0.44 | FALSE |
| 7 | GTEx | Nerve Tibial | AC104532.4 | 0.08 | 0.02 | lasso | 4 | 0.00 | 1.5e-01 | -7.6 | 8.0 | 1.4e-15 | -0.96 | 0.01 | 0.95 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | AC104532.4 | 0.10 | 0.13 | lasso | 2 | 0.12 | 6.1e-10 | -7.6 | 7.6 | 4.2e-14 | -0.86 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Thyroid | CAPS | 0.10 | 0.10 | lasso | 1 | 0.07 | 7.2e-06 | -7.6 | 7.6 | 4.3e-14 | -0.86 | 0.01 | 0.98 | FALSE |
| 10 | GTEx | Thyroid | AC104532.4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 9.3e-07 | -7.6 | 7.5 | 4.7e-14 | -0.88 | 0.02 | 0.98 | FALSE |
| 11 | YFS | Blood | CAPS | 0.08 | 0.13 | bslmm | 357 | 0.13 | 1.6e-41 | -7.4 | 7.0 | 1.9e-12 | -0.84 | 0.02 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VMAC | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.4e-05 | -6.4 | -6.0 | 1.8e-09 | 0.78 | 0.03 | 0.92 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | CAPS | 0.07 | 0.03 | blup | 44 | 0.02 | 3.0e-02 | -7.7 | 6.8 | 8.4e-12 | -0.93 | 0.01 | 0.83 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | VMAC | 0.09 | 0.07 | blup | 44 | 0.08 | 2.6e-05 | -7.5 | 7.6 | 3.4e-14 | -0.88 | 0.01 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FUT5 | 0.21 | 0.04 | lasso | 4 | 0.06 | 2.0e-07 | -3.3 | -6.2 | 5.1e-10 | 0.74 | 0.03 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NDUFA11 | 0.03 | 0.02 | blup | 49 | 0.02 | 1.6e-03 | 4.7 | 5.3 | 1.5e-07 | -0.63 | 0.06 | 0.35 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CAPS | 0.05 | 0.00 | blup | 44 | 0.00 | 2.4e-01 | -3.9 | 6.2 | 7.3e-10 | -0.80 | 0.02 | 0.55 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VMAC | 0.07 | 0.02 | blup | 44 | 0.02 | 1.6e-03 | -7.3 | -5.5 | 3.5e-08 | 0.80 | 0.01 | 0.92 | FALSE |
| 19 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FUT5 | 0.08 | 0.04 | blup | 62 | 0.07 | 1.8e-05 | -6.4 | -6.6 | 4.8e-11 | 0.74 | 0.02 | 0.57 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FUT5 | 0.11 | 0.05 | lasso | 2 | 0.08 | 7.3e-09 | -6.4 | -6.0 | 2.0e-09 | 0.80 | 0.11 | 0.89 | FALSE |
| 21 | The Cancer Genome Atlas | Rectum Adenocarcinoma | VMAC | 0.15 | 0.04 | blup | 44 | 0.10 | 3.1e-03 | -7.7 | 7.5 | 7.8e-14 | -0.93 | 0.01 | 0.55 | FALSE |
| 22 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FUT5 | 0.11 | 0.01 | enet | 12 | 0.04 | 1.6e-03 | -6.0 | -5.6 | 1.9e-08 | 0.58 | 0.02 | 0.15 | FALSE |
| 23 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | VMAC | 0.13 | 0.06 | blup | 44 | 0.08 | 3.5e-03 | -5.6 | -6.9 | 7.1e-12 | 0.90 | 0.01 | 0.65 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | VMAC | 0.07 | 0.07 | enet | 7 | 0.09 | 4.4e-07 | -7.5 | 7.2 | 6.7e-13 | -0.82 | 0.02 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | RANBP3 | 0.09 | 0.09 | lasso | 2 | 0.08 | 2.0e-08 | -5.6 | -5.7 | 1.5e-08 | 0.64 | 0.87 | 0.13 | FALSE |