Hub : Genes

MARC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.294 0.1048 9.4e-03 -0.001 NA 0.046 NA 0.010 3.5e-01 NA 3.2e-02 NA 1.8e-01
2 GTEx Esophagus Mucosa 0.119 0.0450 2.3e-04 0.076 NA 0.042 NA 0.060 9.0e-06 NA 8.2e-04 NA 7.4e-05
3 GTEx Heart Left Ventricle 0.440 0.0791 1.9e-07 0.341 NA 0.311 NA 0.352 7.0e-19 NA 4.6e-17 NA 1.5e-19
4 GTEx Thyroid 0.155 0.0450 2.9e-07 0.164 NA 0.162 NA 0.154 1.3e-12 NA 1.9e-12 NA 6.9e-12
5 GTEx Whole Blood 0.244 0.0540 9.8e-08 0.138 NA 0.116 NA 0.125 1.1e-12 NA 8.0e-11 NA 1.4e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.9 1.4 3.3 -0.6 1.2 0.6 1.2 1.8
Bipolar Disorder or Schizophrenia 0.5 1.2 3.3 0.8 -0.0 1.2 1.8 0.9
Depressed Affect (Nagel 2018) 0.2 0.5 1.3 1.1 -0.4 -0.7 -0.8 -0.2
Depression (Nagel 2018) 0.4 0.5 1.2 0.7 -0.3 -1.1 -0.8 -0.4
Intelligence (Savage-Jansen 2018) 0.6 1.9 3.6 0.5 1.8 -1.9 -1.3 1.0
Neuroticism (Nagel 2018) 0.4 0.8 2.1 1.5 0.4 -1.0 -0.8 0.4
Schizophrenia (2018) 0.6 1.2 1.9 1.3 -1.0 1.1 1.4 -0.3
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 -0.0 -0.7 -0.4 -0.6 -1.0
Worry (Nagel 2018) 0.5 1.0 2.8 1.7 0.5 -1.2 -0.7 -0.1
Alzheimer’s Disease (in mother) 1.3 1.5 4.6 -0.9 0.9 -2.1 -1.1 0.5
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.6 -0.1 -0.2 0.8 0.1
Alzheimer’s Disease (including proxy) 0.3 0.5 1.1 -1.0 0.4 -0.8 -0.0 0.7
Crohns Disease (2017) 1.0 2.3 7.5 1.3 0.4 1.3 -2.7 -0.5
Irritable Bowel Disease (IBD) 1.6 3.9 15.1 0.6 0.4 1.8 -3.9 -0.9
Ulcerative Colitis (UC) 1.2 2.2 8.4 0.2 0.8 1.4 -2.9 -0.1
Major Depression (MDD) 0.9 1.1 3.4 -0.9 -0.5 1.9 1.0 -0.0
Reaction Time 0.2 0.3 0.9 0.3 0.3 -1.0 -0.6 0.3
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.9 1.7 0.9 -1.6 -0.5 0.2
Breast Cancer 0.6 1.3 2.5 1.6 -0.4 1.6 1.2 -0.1
Ovarian Cancer 0.3 0.3 1.2 -0.5 0.1 1.1 -0.2 0.3
Prostate Cancer 0.6 0.8 2.1 0.1 1.4 -0.3 0.2 1.3
Age at First Birth 0.2 0.3 0.6 0.7 0.0 0.2 -0.7 -0.5
Bipolar Disorder (2011) 0.6 0.6 1.8 -0.2 0.6 0.4 0.8 1.3
Body Mass Index (BMI) (2010) 0.6 0.9 2.4 0.4 0.8 -1.6 -1.0 0.3
Coronary Artery Disease (CAD) 0.8 1.0 4.5 0.3 -0.3 2.1 0.0 0.4
Crohns Disease (2012) 0.4 0.6 1.7 0.1 -0.1 1.3 -0.9 -0.6
Mean Putamen Volume 1.2 1.4 3.6 -1.9 0.5 0.9 0.5 1.5
Fasting Glucose 0.3 0.4 1.2 -0.6 -0.1 -0.3 0.4 -1.1
HbA1C 3.8 4.3 11.9 -0.4 -2.7 -1.4 -0.5 -3.4
HDL Cholesterol 2.2 3.6 7.5 1.8 1.4 2.7 -2.0 1.0
LDL Cholesterol 1.6 2.5 6.0 2.4 -0.5 2.4 0.6 -0.6
Lupus 0.5 0.7 2.8 -1.7 0.1 0.1 -0.8 0.2
Neuroticism (2016) 0.8 1.2 2.5 0.8 1.6 -1.0 -0.5 1.4
Primary Biliary Cirrhosis 0.2 0.3 1.0 -1.0 -0.2 0.7 0.2 0.4
Rheumatoid Arthritis 0.5 0.7 2.1 1.4 0.5 -0.6 0.6 0.5
Schizophrenia (2014) 0.3 0.8 2.1 0.2 -0.5 1.1 1.4 0.4
Triglycerides 1.4 2.2 4.6 0.7 -1.3 -2.1 1.6 -1.4
Type 2 Diabetes (T2D) (2012) 1.5 1.8 5.1 -0.9 -2.3 0.8 1.0 -1.3
Ulcerative Colitis 1.7 2.5 9.5 -0.9 -0.0 0.8 -3.1 -1.1
Blood Eosinophil Count 0.7 5.1 20.6 -4.5 -2.0 0.9 0.1 -0.5
Blood Platelet Count 0.4 4.4 11.4 -3.4 0.3 1.5 -2.9 0.5
Blood Red Count 0.2 2.3 5.7 -2.3 -0.4 -0.3 2.4 0.4
Blood White Count 0.3 2.5 9.2 -3.0 -0.9 -0.9 -0.2 -1.2
Heel T-Score 0.4 3.1 9.9 -1.0 -0.9 -1.5 -1.3 -3.1
BMI 0.3 2.0 2.9 -1.2 1.6 -1.1 -1.4 1.7
Height 0.2 3.7 5.0 -2.2 2.0 -2.1 -2.2 0.5
Waist Hip Ratio (WHR) 1.4 6.1 21.0 -4.6 -2.2 1.0 -0.0 -1.9
Systolic Blood Pressure 0.2 0.9 3.1 -0.3 0.1 -0.1 1.8 1.0
Smoking Status 0.3 0.7 1.8 -0.2 -0.3 1.0 -1.4 -0.7
Allergy or Eczema 0.4 1.1 2.7 -1.6 -1.1 -0.0 1.1 -0.5
Cardiovascular Disease 0.9 2.9 6.0 -2.4 -1.6 1.9 -0.8 -1.2
Hypothyroidism (self reported) 0.4 0.9 1.7 1.2 -1.3 -0.4 0.2 -1.1
Respiratory disease 0.3 0.7 1.5 -0.6 1.2 0.2 -0.5 1.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.8 -0.7 -0.0 -0.9 -1.7 -1.0
Lung FEV1/FVC ratio 1.0 4.9 12.5 -3.5 0.1 -1.1 -3.0 -1.2
Lung FVC 1.6 8.1 27.7 3.6 -0.2 -5.3 0.1 -0.2
Neuroticism 0.5 1.3 1.8 1.2 1.4 -1.1 -1.1 1.0
Chronotype (morning person) 1.0 2.3 6.0 -2.4 -1.3 1.4 -0.5 -1.3
Hair Pigment 0.0 0.3 0.4 -0.4 0.6 0.3 -0.6 0.7
Tanning 0.3 3.1 6.8 1.3 -2.0 -1.1 -1.3 -2.6
Hand grip strength (left) 0.6 1.5 3.8 0.2 2.0 -0.6 -0.1 1.9
Number of treatments/medications taken 1.2 2.1 4.4 -1.9 1.1 0.7 -2.1 0.9
Average weekly spirits intake 0.8 0.9 2.6 0.6 -0.2 1.1 -1.6 -0.7
Sensitivity / hurt feelings 0.3 0.5 1.8 0.2 0.8 -0.1 -0.0 1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 0.8 0.3 -0.6 -0.7 0.1
Hearing difficulty/problems: Yes 0.7 1.0 2.3 -0.4 0.8 1.3 -1.5 0.6
Relative age of first facial hair 1.5 3.2 11.7 3.4 -0.1 -0.7 -1.5 -1.2
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 4.3 1.7 0.0 2.1 0.4 -0.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 4.8 0.3 2.0 0.2 0.4 2.2
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 0.0 -1.2 0.7 0.4 -0.9
Systolic blood pressure, automated reading 0.2 0.7 2.1 -1.4 0.8 -0.3 -0.2 0.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.0 0.5 0.8 -1.4 -0.5 0.7
Angina 0.3 0.4 0.5 0.7 -0.6 0.7 0.4 -0.5
Medication for hormone replacement therapy 0.2 0.2 0.4 -0.2 0.7 -0.3 0.2 0.5
Vitamin and mineral supplements 1.3 1.7 4.4 -0.3 1.8 0.8 -0.5 2.1
Supplements: Zinc 0.7 0.7 2.1 -0.2 0.8 -1.5 -0.7 0.5
Medication: Co-codamol 1.1 1.3 2.7 -1.6 0.8 -1.0 -1.6 0.1
Medication: Metformin 1.1 1.6 4.3 -1.1 0.4 -1.5 -2.1 -0.3
Diabetes (father) 2.3 2.9 6.6 -2.5 0.1 -0.7 -2.6 -0.8
Diabetes (mother) 0.6 0.8 2.0 1.4 0.6 0.2 0.9 0.8
Severe depression (siblings) 0.6 0.7 1.2 0.2 1.1 -0.8 0.7 1.0
Pack years adult smoking proportion 0.5 0.8 2.2 -0.0 -0.9 1.5 0.0 -1.0
Impedance of leg (right) 0.9 4.1 6.7 -1.6 -2.6 1.7 1.5 -2.5
Leg fat-free mass (left) 1.0 5.2 9.8 0.2 3.1 -1.9 -2.0 3.0
Trunk fat percentage 0.2 1.0 2.4 -1.5 0.0 0.4 -1.6 -0.1
Hand grip strength (right) 0.4 1.0 2.1 0.6 1.4 -0.8 0.2 1.3
Townsend deprivation index at recruitment 0.4 0.6 1.1 0.3 -0.9 0.4 -0.9 -1.0
Current tobacco smoking 0.6 1.0 1.9 0.9 -1.0 1.4 -0.2 -1.1
Average weekly fortified wine intake 0.7 0.9 2.0 -0.3 -0.9 1.1 0.2 -1.4
Maternal smoking around birth 0.9 1.3 3.1 -0.3 1.5 -0.5 -1.8 0.9
Fed-up feelings 0.4 0.6 2.0 1.0 0.0 -1.4 -0.2 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.4 -0.1 -0.2 -1.5 -1.0 -0.7
Relative age voice broke 0.8 1.2 3.4 1.8 0.2 -1.0 -1.1 -0.4
Taking other prescription medications 1.1 1.7 4.2 -1.5 0.0 1.4 -2.0 0.3
Age when periods started (menarche) 1.3 3.0 5.1 2.3 -1.8 -1.0 1.3 -2.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.9 -0.9 0.1 -0.1 -0.1 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.4 5.0 -1.6 -1.1 -1.6 -0.6 -2.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.5 0.7 1.0 -0.0 0.3 1.2
Qualifications: CSEs or equivalent 1.0 1.3 2.6 0.3 1.2 0.7 -1.6 1.3
Serious illness, injury or assault to yourself 1.2 1.5 2.2 1.0 1.5 1.2 0.7 1.4
High blood pressure 0.3 0.9 3.1 -1.8 -0.6 0.1 -1.0 -0.4
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.5 -1.2 -0.4 -0.4 0.8 -0.2
Multivitamins +/- minerals 2.5 3.1 8.1 -0.6 -2.6 -0.0 0.5 -2.8
Stomach or abdominal pain in last month 4.1 5.1 15.9 -1.5 2.2 0.3 -4.0 1.5
Supplements: Glucosamine 0.8 1.0 1.8 -0.1 -1.3 -0.5 1.3 -1.1
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 6.2 -2.5 -1.7 0.2 -0.9 -1.6
Medication: Atenolol 1.0 1.3 2.7 -1.5 -0.7 0.5 -1.6 -0.7
Medication: Levothyroxine sodium 0.7 1.1 2.4 0.9 -1.6 -0.7 1.2 -0.7
Sitting height 0.3 1.9 4.8 0.2 2.0 0.3 0.5 2.2
Chronic bronchitis/emphysema (father) 1.3 1.5 3.7 1.6 0.3 -1.9 1.0 -0.2
High blood pressure (mother) 1.2 1.6 2.5 0.4 1.4 1.6 -1.3 1.4
Body mass index (BMI) 0.5 2.0 4.1 -0.4 1.8 -0.6 -1.6 2.0
Impedance of leg (left) 1.3 6.2 10.2 -1.6 -3.2 2.6 1.6 -3.0
Leg predicted mass (left) 1.0 5.2 10.0 0.2 3.2 -1.8 -2.0 3.0
Trunk fat mass 0.3 1.5 3.6 -1.4 1.0 -0.2 -1.9 0.8
Waist circumference 0.5 1.7 4.7 -2.2 0.9 -0.1 -1.2 1.2
Number of incorrect matches in round 0.3 0.5 1.4 0.6 -0.7 0.2 1.2 -0.1
Past tobacco smoking 0.2 0.4 0.7 -0.2 0.6 0.2 0.9 0.8
Alcohol usually taken with meals 0.4 0.7 2.4 -0.1 0.6 1.6 0.5 0.7
Nervous feelings 0.1 0.2 0.9 0.3 -0.0 -1.0 0.4 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.4 0.8 -0.0 0.7 1.2 0.0
Hearing difficulty/problems with background noise 0.2 0.3 0.8 0.4 0.4 0.9 -0.7 0.2
Hair/balding pattern: Pattern 2 0.9 1.1 4.1 -0.6 1.0 -0.1 -2.0 0.4
Had menopause 0.7 0.9 2.3 0.4 1.0 -1.5 -0.9 0.6
Had other major operations 0.8 0.9 3.6 0.8 0.4 0.4 -1.9 -0.0
Forced vital capacity (FVC) 0.9 3.3 12.1 1.8 0.7 -3.5 -0.7 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.3 -0.6 -0.4 -1.2 -0.9 -1.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.2 0.2 -1.1 0.0 -0.6 -1.5
Qualifications: None of the above 0.5 1.0 2.0 -1.0 -0.4 1.4 1.3 0.5
Financial difficulties in last 2 years 0.2 0.3 1.0 0.7 0.1 -0.1 1.0 0.2
Mouth/teeth dental problems 0.1 0.1 0.4 0.7 -0.1 0.3 0.1 -0.4
Heart attack 1.5 1.9 3.0 -0.6 1.7 1.5 -1.2 1.6
Allergy 0.3 0.7 1.6 0.6 -1.3 0.4 0.4 -1.1
Pain all over the body in last month 0.4 0.4 1.3 -0.2 -0.1 1.1 -0.8 -0.4
Diabetes (self-reported) 1.7 2.7 6.9 0.3 0.8 -2.3 -2.6 -0.7
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 9.0 -3.0 -0.0 0.5 0.7 0.7
Medication: Ramipril 0.5 0.6 1.5 -0.2 -0.6 0.4 -1.2 -1.1
Medication: Simvastatin 0.7 1.1 3.0 0.0 0.2 1.7 -1.5 -0.4
Fluid intelligence score 0.8 1.6 5.0 2.2 -0.4 -1.4 0.2 -0.9
Illnesses of siblings 0.0 0.0 0.1 0.0 -0.3 0.0 0.2 -0.4
Neuroticism score 0.8 1.8 2.8 1.5 1.7 -0.2 -1.2 1.6
Weight 0.6 2.7 4.9 -0.9 2.2 -0.9 -1.6 2.2
Impedance of arm (right) 1.4 6.4 16.8 -1.1 -3.5 1.2 0.4 -4.1
Arm fat percentage (right) 0.2 0.8 2.7 -1.1 0.3 0.2 -1.6 0.2
Trunk fat-free mass 1.1 6.1 12.7 -0.6 3.4 -1.9 -1.3 3.6
Hip circumference 0.2 0.9 2.4 0.4 1.3 -0.3 -0.6 1.5
Time employed in main current job 2.1 2.4 5.5 2.4 1.4 -1.7 -0.1 1.2
Alcohol intake versus 10 years previously 1.4 2.1 5.6 -2.4 -1.2 0.7 -1.1 -1.2
Father’s age at death 0.2 0.2 0.5 0.4 0.5 -0.7 0.3 0.5
Worrier / anxious feelings 0.5 0.9 1.6 1.0 1.1 -0.4 -1.2 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.1 0.7 -0.7 -0.3 0.8
Falls in the last year 0.9 1.2 2.5 -0.2 -1.6 -0.6 1.1 -1.4
Hair/balding pattern: Pattern 3 0.3 0.4 0.8 -0.3 -0.6 -0.5 0.9 -0.6
Number of live births 0.5 0.7 2.4 -0.1 -1.0 -0.2 1.5 -0.2
Forced expiratory volume in 1-second (FEV1) 0.9 3.2 13.3 0.6 0.8 -3.6 -1.3 0.1
Pulse rate 0.3 0.4 2.0 -0.0 -0.3 0.2 1.4 0.1
Happiness 0.2 0.3 1.1 0.4 0.3 -1.0 -0.4 0.3
Noisy workplace 0.8 1.0 1.5 -0.8 1.2 -0.7 -1.1 0.9
Qualifications: A levels/AS levels or equivalent 1.3 2.9 3.8 1.6 1.6 -1.6 2.0 1.8
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.6 1.3 -0.8 1.2 1.2 -0.7
Mouth/teeth dental problems: Dentures 0.1 0.1 0.3 -0.3 -0.2 -0.2 -0.6 -0.2
Asthma 0.5 0.9 1.9 -0.7 1.0 0.3 -1.4 1.0
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 3.8 1.5 1.9 -0.7 0.4 1.9
Medication: Cholesterol lowering 1.7 2.7 5.4 -0.5 -1.6 2.3 -1.2 -1.9
Depression (self-reported) 0.7 0.8 2.0 0.1 1.1 -0.7 -1.4 0.7
Medication: Lansoprazole 0.1 0.1 0.2 -0.1 -0.2 0.4 0.5 -0.2
Prospective memory result 0.1 0.1 0.3 -0.1 0.1 0.2 0.3 0.6
Lung cancer (father) 1.4 1.6 3.5 -0.8 1.9 -0.5 -0.6 1.8
Illnesses of mother 0.4 0.4 1.2 -0.7 -0.1 -1.1 0.7 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 10.9 0.7 0.3 -3.3 -0.8 -0.2
Pulse wave Arterial Stiffness index 2.2 2.6 5.8 -1.4 2.1 -0.8 0.1 2.4
Impedance of arm (left) 1.1 5.0 13.8 -1.1 -3.1 0.7 0.2 -3.7
Arm fat mass (right) 0.4 1.8 3.3 -1.0 1.5 -0.2 -1.8 1.6
Trunk predicted mass 1.0 5.9 12.2 -0.6 3.4 -2.0 -1.2 3.5
Standing height 0.1 0.9 1.6 -1.2 1.2 -0.9 -0.2 0.9
Length of working week for main job 3.0 3.3 5.8 2.4 0.6 2.3 1.4 1.8
Exposure to tobacco smoke at home 0.7 0.8 1.2 1.1 1.1 -0.6 -0.7 0.8
Breastfed as a baby 2.0 2.4 9.5 3.1 0.3 -1.5 0.4 -0.3
Tense / ‘highly strung’ 1.2 1.9 4.7 1.2 2.2 -0.4 -0.1 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.8 3.4 1.8 0.1 0.8 0.3 0.3
Hair/balding pattern: Pattern 4 0.1 0.4 0.6 -0.6 -0.8 -0.2 0.7 -0.7
Birth weight of first child 0.6 1.1 3.9 -0.7 -0.8 0.4 2.0 0.0
Peak expiratory flow (PEF) 0.8 1.9 4.1 1.5 0.5 -2.0 -1.6 -0.1
Pulse wave reflection index 0.8 1.0 1.7 -1.0 1.1 -1.3 -0.5 0.9
Ever highly irritable/argumentative for 2 days 1.8 2.2 7.8 0.1 0.4 -1.6 -2.8 -0.7
Loud music exposure frequency 0.2 0.2 0.3 -0.2 0.6 0.5 -0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.6 0.7 1.4 -1.0 -1.6 0.8
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.6 -1.3 -0.1 0.1 -0.4 0.4
Blood clot in the leg (DVT) 2.2 2.8 4.4 0.7 2.1 -1.9 -2.0 1.3
Medication: Paracetamol 0.6 0.9 1.7 -0.2 1.3 -1.1 -0.7 1.2
Headache pain in last month 0.6 1.0 2.5 1.6 0.1 -1.5 0.1 0.1
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 3.8 1.9 1.0 -0.2 1.9 1.6
Glaucoma (self-reported) 1.7 2.0 5.3 -0.5 -2.0 0.8 -0.0 -2.3
Gout (self-reported) 0.5 0.6 2.4 0.2 0.5 -1.6 -0.7 -0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 0.8 -0.4 -0.6 -0.5 -0.1
Medication: Amlodipine 0.1 0.2 0.3 -0.2 0.5 -0.6 -0.6 0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.9 -1.7 0.4 -0.5 -1.2 0.3
Birth weight 0.5 1.0 4.5 -2.1 0.4 -0.1 0.5 0.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.5 0.6 -0.5 -1.2 -0.4 -0.8
High blood pressure (siblings) 0.4 0.5 1.7 -0.9 0.3 0.1 -1.3 0.1
Forced vital capacity (FVC), Best measure 0.8 2.9 10.0 1.9 0.5 -3.2 -0.6 0.1
Body fat percentage 0.2 0.8 2.3 -1.2 0.1 0.2 -1.5 -0.0
Leg fat percentage (right) 0.1 0.4 0.9 -0.7 0.4 -0.1 -0.9 0.5
Arm fat-free mass (right) 1.3 6.7 16.2 -0.3 3.6 -1.6 -1.2 4.0
Exposure to tobacco smoke outside home 1.1 1.5 2.9 1.7 1.4 1.2 0.3 1.1
Comparative body size at age 10 0.7 2.0 4.1 1.5 2.0 -0.4 -0.7 1.8
Number of full brothers 0.2 0.3 1.0 -0.5 0.2 -0.0 1.0 0.4
Worry too long after embarrassment 0.7 1.2 2.6 1.2 1.4 -0.1 0.0 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.3 1.0 -0.5 1.1 0.1 -0.7
Wheeze or whistling in the chest in last year 0.4 0.8 2.0 0.2 0.9 1.0 0.4 1.4
Number of children fathered 0.2 0.2 0.4 -0.2 -0.6 -0.2 -0.0 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 4.1 4.8 9.5 -0.1 -3.1 0.8 3.0 -2.2
Age at first live birth 0.1 0.1 0.3 -0.0 0.0 -0.5 0.5 0.3
Pulse wave peak to peak time 2.2 2.6 6.0 1.5 -2.1 0.6 -0.0 -2.5
Health satisfaction 0.9 1.2 3.2 -1.1 1.0 -0.5 -1.8 0.5
Shortness of breath walking on level ground 1.9 2.2 6.5 -1.8 1.1 -0.3 -2.5 0.3
Qualifications: College or University degree 0.5 1.4 3.8 1.3 0.3 1.1 1.9 0.5
Eye problems/disorders: None of the above 1.0 1.2 2.9 1.5 0.1 0.5 1.7 0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 1.7 -1.3 -1.0 1.3 0.8 -0.7
Emphysema/chronic bronchitis 2.0 2.2 3.8 -1.6 -1.4 1.9 1.4 -1.0
Medication for pain relief, constipation, heartburn 0.6 1.0 1.8 0.1 -1.3 -1.0 0.8 -1.3
Neck or shoulder pain in last month 1.5 2.1 4.7 2.2 0.8 -2.2 -0.2 0.6
Medication: Blood pressure 0.7 1.2 3.1 -1.8 0.2 -0.6 -1.5 -0.4
Angina (self-reported) 0.2 0.2 0.3 0.5 -0.6 0.6 0.4 -0.4
Migraine (self-reported) 1.5 1.9 4.1 -0.5 1.5 -1.4 -2.0 1.1
Medication: Ibuprofen 1.5 1.8 4.2 0.9 2.1 -0.8 0.1 1.8
Medication: Allopurinol 1.3 1.7 7.7 0.5 0.2 -2.8 -0.8 -0.4
Medication: Omeprazole 1.8 2.1 4.6 -1.9 -0.7 0.4 -2.1 -1.3
Medication: Seretide 50 evohaler 1.8 2.1 3.9 -1.7 1.8 -0.0 0.6 2.0
Mean time to correctly identify matches 0.2 0.4 1.0 0.4 -0.4 -1.0 -0.6 -0.6
Heart disease (mother) 1.3 1.6 3.2 -0.4 1.8 0.7 -1.2 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.6 0.1 1.1 0.9 -1.3 0.6
Whole body fat mass 0.4 1.6 4.1 -1.2 1.1 -0.3 -2.0 0.9
Leg fat mass (right) 0.4 1.5 3.1 -0.7 1.4 -0.5 -1.8 1.4
Arm predicted mass (right) 1.2 6.3 15.4 -0.2 3.6 -1.2 -1.4 3.9
Pulse rate, automated reading 0.1 0.4 1.0 -1.0 0.5 -0.2 -0.1 0.8
Alcohol intake frequency. 0.8 1.9 8.7 0.2 -0.4 3.0 -0.9 -0.2
Comparative height size at age 10 0.3 1.6 6.9 -2.6 -0.0 1.1 -0.2 -0.1
Number of full sisters 0.1 0.2 0.6 -0.5 -0.0 0.0 -0.8 -0.1
Suffer from ‘nerves’ 0.3 0.5 1.4 -0.9 0.4 -0.2 -1.2 0.1
Overall health rating 0.1 0.3 0.7 -0.3 -0.1 0.8 -0.8 0.1
Chest pain or discomfort 0.9 1.3 3.9 -0.8 0.8 1.0 -2.0 0.2
Had major operations 0.9 1.0 2.2 0.3 -1.5 1.2 -0.2 -1.1
Age at last live birth 0.9 1.3 3.8 1.1 -1.0 0.5 2.0 -0.3
Family relationship satisfaction 0.4 0.5 2.1 1.5 0.1 -0.1 -0.5 0.1
Leg pain on walking 1.1 1.4 4.4 -2.1 -0.4 0.9 -0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.7 1.9 -0.6 -0.0 1.0 -1.4 -0.2
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.4 -0.3 1.2 0.7 -0.9 1.6
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 4.7 -2.1 0.3 0.2 -2.2 0.0
Medication: Aspirin 0.1 0.2 0.5 0.2 -0.0 0.7 -0.5 -0.3
Supplements: Vitamin C 0.3 0.3 1.1 0.0 0.5 -1.0 -0.4 0.2
Knee pain experienced in last month 0.7 1.1 2.7 -0.6 0.8 -0.5 -1.7 1.2
Hypertension (Self-reported) 0.4 1.0 3.1 -1.8 -0.8 -0.0 -1.0 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 1.7 -1.1 1.3 -0.6 -1.1 0.9
Illnesses of father: Heart disease 0.4 0.5 1.8 1.3 0.1 0.8 0.2 0.1
Illnesses of siblings: Diabetes 1.2 1.5 4.8 0.1 1.2 -0.3 -2.2 1.2
Smoking status: Previous 0.3 0.5 1.0 -0.9 -0.3 -0.6 -1.0 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.1 0.2 0.7 -0.2 0.1 1.0
Whole body fat-free mass 1.0 5.5 11.4 -0.3 3.3 -1.7 -1.5 3.4
Leg fat-free mass (right) 0.8 4.1 7.8 0.5 2.8 -1.4 -1.9 2.6
Arm fat percentage (left) 0.2 1.0 3.3 -1.0 0.6 -0.3 -1.8 0.5
Average weekly red wine intake 0.8 1.2 4.1 0.7 0.6 -0.1 2.0 0.9
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.8 1.6 1.7 -0.4 -0.9 0.8
Mood swings 0.1 0.2 0.5 0.7 0.2 -0.1 -0.5 0.6
Loneliness, isolation 0.1 0.1 0.2 0.5 0.2 -0.2 -0.3 0.3
Long-standing illness, disability or infirmity 0.1 0.1 0.3 0.3 0.0 0.6 0.0 0.1
Ever had bowel cancer screening 2.2 2.6 5.3 -1.0 2.3 0.4 -2.2 1.2
Diabetes diagnosed by doctor 1.6 2.6 6.3 0.6 1.2 -2.3 -2.5 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.2 -0.6 -0.2 -1.0 -0.9 -1.1
Friendships satisfaction 0.4 0.6 2.1 1.5 -0.3 0.0 -0.7 -0.3
Qualifications: nursing, teaching 0.8 1.2 3.5 0.0 1.9 -0.6 -0.3 1.4
Commuting to job workplace: Walk 0.1 0.1 0.3 0.1 0.4 -0.5 -0.3 -0.0
Eye problems/disorders: Cataract 0.6 0.7 1.6 0.7 -0.1 -0.4 -1.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.7 0.2 -0.3 0.8 0.6 -0.1
Medication for cholesterol 1.1 1.6 4.0 0.4 -0.9 -2.0 0.5 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.3 0.6 -0.6 -1.1 0.4 -0.7
Back pain experienced in last month 0.1 0.2 0.6 -0.4 -0.2 0.7 0.3 0.3
Mineral and other dietary supplements 1.2 1.7 3.3 1.8 1.5 0.7 -0.4 1.4
Breast cancer (self-reported) 0.3 0.4 0.9 0.2 0.8 0.5 -0.9 0.3
Asthma (self-reported) 0.6 1.1 2.2 -1.0 1.1 0.3 -1.5 1.1
Osteoporosis (self-reported) 0.3 0.4 1.3 0.7 0.4 -1.1 -0.1 0.2
Osteoarthritis (self-reported) 3.4 4.4 21.5 -4.6 -0.0 0.3 0.3 0.5
Medication: Aspirin 0.3 0.3 1.4 0.1 0.3 0.4 -1.2 -0.3
Medication: Gliclazide 0.8 0.9 1.7 -0.0 -0.4 -1.1 -1.3 -1.2
Illnesses of father: None of the above (group 1) 0.2 0.2 0.3 -0.3 -0.5 0.5 -0.2 -0.6
Smoking status: Current 0.7 1.1 2.9 1.0 -0.9 1.7 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 7.1 -0.4 0.5 -2.7 -0.8 0.3
Whole body water mass 1.0 5.6 11.7 -0.2 3.3 -1.8 -1.5 3.4
Leg predicted mass (right) 0.8 4.2 7.9 0.6 2.8 -1.4 -1.8 2.7
Arm fat mass (left) 0.5 2.2 3.7 -1.1 1.7 -0.4 -1.9 1.7
Number of self-reported non-cancer illnesses 2.0 3.5 10.9 -3.3 -0.0 2.1 -1.3 0.9
Average weekly champagne plus white wine intake 0.3 0.4 1.0 0.4 0.4 -0.9 1.0 0.2
Miserableness 0.9 1.5 2.7 0.9 -1.6 0.2 -1.2 -1.6
Guilty feelings 0.4 0.7 1.5 1.2 0.6 1.0 -0.3 0.6
Wears glasses or contact lenses 0.4 0.5 0.9 0.2 -1.0 0.2 0.7 -0.9
Ever taken oral contraceptive pill 1.3 1.4 2.9 -1.5 -1.0 -1.7 -0.4 -0.8
Hearing aid user 0.3 0.4 0.8 -0.6 -0.9 -0.2 -0.4 -0.7
Mother’s age at death 0.6 0.7 2.9 0.6 0.6 -1.7 0.1 -0.3
Financial situation satisfaction 0.8 1.0 2.4 -0.1 1.0 -1.1 -1.6 0.7
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 0.0 0.2 0.0 -0.0 0.1
Commuting to job workplace: Public transport 2.9 3.4 8.2 -0.0 -2.7 -0.9 0.9 -2.9
Eye problems/disorders: Glaucoma 0.8 1.0 2.5 -0.5 -1.4 0.4 -0.2 -1.6
Medication: Blood pressure 0.3 0.7 2.5 -0.3 -0.7 1.6 0.1 0.3
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.2 -1.3 1.7 1.0 0.5 2.1
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.9 -1.2 -2.0 -0.8 1.2 -1.7
High cholesterol (Self-reported) 1.7 3.0 8.6 -1.8 -0.8 2.9 -1.4 -0.9
Medication: Bendroflumethiazide 0.3 0.4 1.2 0.1 0.1 -0.9 -1.1 -0.0
Medication: Paracetamol 0.2 0.3 0.5 -0.7 0.4 -0.1 -0.7 0.4
Medication: Lisinopril 0.6 0.8 1.4 1.2 -1.0 -0.9 -0.2 -0.9
Medication: Atorvastatin 1.1 1.4 4.0 0.4 -1.1 2.0 -0.0 -1.2
Illnesses of father: High blood pressure 1.4 1.7 3.4 1.2 1.8 -0.7 0.5 1.9
Alcohol drinker status: Never 0.4 0.5 1.3 -0.6 0.6 -0.2 -1.1 0.6
Ever smoked 0.5 0.8 1.8 0.6 -0.6 -0.7 -1.4 -1.0
Basal metabolic rate 0.9 5.0 10.2 -0.4 3.1 -1.5 -1.6 3.2
Leg fat percentage (left) 0.1 0.4 0.9 -0.7 0.2 0.5 -0.9 0.3
Arm fat-free mass (left) 1.0 4.9 13.0 -0.4 3.1 -1.1 -0.7 3.6
Number of operations (self-reported) 0.3 0.4 1.3 1.1 -0.5 0.3 -0.5 -0.6
Average weekly beer plus cider intake 0.5 0.7 1.1 -0.1 0.7 1.1 -0.9 1.1
Irritability 0.9 1.5 3.0 -0.1 1.7 -1.0 -1.5 1.2
Risk taking 1.3 1.9 3.9 0.2 1.2 1.0 2.0 1.8
Ever had prostate specific antigen (PSA) test 0.8 1.0 3.1 -1.1 -0.2 -0.2 -1.8 -0.7
Fractured/broken bones in last 5 years 0.6 0.7 1.6 0.6 -0.7 0.8 -1.2 -0.9
Age started oral contraceptive pill 0.4 0.4 0.9 -0.9 -0.8 0.5 0.3 -0.6
Diastolic blood pressure, automated reading 0.2 0.7 1.6 -1.1 -0.7 -0.3 1.3 -0.1
Ever depressed for a whole week 0.2 0.3 0.9 0.4 -0.5 0.0 0.9 -0.5
Unable to work because of sickness or disability 0.7 1.0 2.1 0.5 -1.4 0.4 0.7 -1.4
Commuting to job workplace: Cycle 1.4 1.7 4.2 -0.1 -2.0 -0.6 -0.4 -2.0
Myopia 1.7 2.5 7.6 1.2 0.1 2.8 1.8 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.8 2.2 0.5 -0.9 0.9 0.1
Cholesterol lowering medication 1.0 1.5 2.5 1.0 1.3 1.6 -1.1 1.1
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 5.9 -1.9 -0.6 0.4 -2.4 -1.3
Pain experienced in last month 0.5 0.8 3.0 -0.3 -1.0 0.0 0.2 -1.7
Supplements: Calcium 1.2 1.3 2.6 0.3 1.2 -1.6 0.8 1.4
Basal cell carcinoma (self-reported) 0.8 1.0 2.9 -0.1 1.7 -0.2 0.4 1.3
Heart attack/myocardial infarction (self-reported) 1.1 1.5 2.1 -0.5 1.5 1.4 -1.1 1.3
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 4.4 0.6 2.1 -2.1 -1.9 1.3
Heart disease (siblings) 0.7 0.8 1.7 -0.9 1.1 0.7 0.1 1.3
Alcohol drinker status: Previous 2.1 2.4 8.8 3.0 -0.5 1.5 0.8 -0.4
Pack years of smoking 0.4 0.6 1.5 -0.4 -0.7 1.2 0.2 -0.8
Impedance of whole body 1.3 6.6 13.0 -1.4 -3.5 1.9 1.5 -3.6
Leg fat mass (left) 0.3 1.3 2.8 -0.8 1.3 -0.0 -1.7 1.3
Arm predicted mass (left) 1.0 4.9 11.9 -0.8 3.0 -1.2 -1.0 3.5