Hub : Genes

MARC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.294	0.1048	9.4e-03	-0.001	NA	0.046	NA	0.010	3.5e-01	NA	3.2e-02	NA	1.8e-01
2	GTEx	Esophagus Mucosa	0.119	0.0450	2.3e-04	0.076	NA	0.042	NA	0.060	9.0e-06	NA	8.2e-04	NA	7.4e-05
3	GTEx	Heart Left Ventricle	0.440	0.0791	1.9e-07	0.341	NA	0.311	NA	0.352	7.0e-19	NA	4.6e-17	NA	1.5e-19
4	GTEx	Thyroid	0.155	0.0450	2.9e-07	0.164	NA	0.162	NA	0.154	1.3e-12	NA	1.9e-12	NA	6.9e-12
5	GTEx	Whole Blood	0.244	0.0540	9.8e-08	0.138	NA	0.116	NA	0.125	1.1e-12	NA	8.0e-11	NA	1.4e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	3.3	-0.6	1.2	0.6	1.2	1.8
Bipolar Disorder or Schizophrenia	0.5	1.2	3.3	0.8	-0.0	1.2	1.8	0.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	1.1	-0.4	-0.7	-0.8	-0.2
Depression (Nagel 2018)	0.4	0.5	1.2	0.7	-0.3	-1.1	-0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.6	0.5	1.8	-1.9	-1.3	1.0
Neuroticism (Nagel 2018)	0.4	0.8	2.1	1.5	0.4	-1.0	-0.8	0.4
Schizophrenia (2018)	0.6	1.2	1.9	1.3	-1.0	1.1	1.4	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-0.0	-0.7	-0.4	-0.6	-1.0
Worry (Nagel 2018)	0.5	1.0	2.8	1.7	0.5	-1.2	-0.7	-0.1
Alzheimer’s Disease (in mother)	1.3	1.5	4.6	-0.9	0.9	-2.1	-1.1	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.6	-0.1	-0.2	0.8	0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	-1.0	0.4	-0.8	-0.0	0.7
Crohns Disease (2017)	1.0	2.3	7.5	1.3	0.4	1.3	-2.7	-0.5
Irritable Bowel Disease (IBD)	1.6	3.9	15.1	0.6	0.4	1.8	-3.9	-0.9
Ulcerative Colitis (UC)	1.2	2.2	8.4	0.2	0.8	1.4	-2.9	-0.1
Major Depression (MDD)	0.9	1.1	3.4	-0.9	-0.5	1.9	1.0	-0.0
Reaction Time	0.2	0.3	0.9	0.3	0.3	-1.0	-0.6	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.9	1.7	0.9	-1.6	-0.5	0.2
Breast Cancer	0.6	1.3	2.5	1.6	-0.4	1.6	1.2	-0.1
Ovarian Cancer	0.3	0.3	1.2	-0.5	0.1	1.1	-0.2	0.3
Prostate Cancer	0.6	0.8	2.1	0.1	1.4	-0.3	0.2	1.3
Age at First Birth	0.2	0.3	0.6	0.7	0.0	0.2	-0.7	-0.5
Bipolar Disorder (2011)	0.6	0.6	1.8	-0.2	0.6	0.4	0.8	1.3
Body Mass Index (BMI) (2010)	0.6	0.9	2.4	0.4	0.8	-1.6	-1.0	0.3
Coronary Artery Disease (CAD)	0.8	1.0	4.5	0.3	-0.3	2.1	0.0	0.4
Crohns Disease (2012)	0.4	0.6	1.7	0.1	-0.1	1.3	-0.9	-0.6
Mean Putamen Volume	1.2	1.4	3.6	-1.9	0.5	0.9	0.5	1.5
Fasting Glucose	0.3	0.4	1.2	-0.6	-0.1	-0.3	0.4	-1.1
HbA1C	3.8	4.3	11.9	-0.4	-2.7	-1.4	-0.5	-3.4
HDL Cholesterol	2.2	3.6	7.5	1.8	1.4	2.7	-2.0	1.0
LDL Cholesterol	1.6	2.5	6.0	2.4	-0.5	2.4	0.6	-0.6
Lupus	0.5	0.7	2.8	-1.7	0.1	0.1	-0.8	0.2
Neuroticism (2016)	0.8	1.2	2.5	0.8	1.6	-1.0	-0.5	1.4
Primary Biliary Cirrhosis	0.2	0.3	1.0	-1.0	-0.2	0.7	0.2	0.4
Rheumatoid Arthritis	0.5	0.7	2.1	1.4	0.5	-0.6	0.6	0.5
Schizophrenia (2014)	0.3	0.8	2.1	0.2	-0.5	1.1	1.4	0.4
Triglycerides	1.4	2.2	4.6	0.7	-1.3	-2.1	1.6	-1.4
Type 2 Diabetes (T2D) (2012)	1.5	1.8	5.1	-0.9	-2.3	0.8	1.0	-1.3
Ulcerative Colitis	1.7	2.5	9.5	-0.9	-0.0	0.8	-3.1	-1.1
Blood Eosinophil Count	0.7	5.1	20.6	-4.5	-2.0	0.9	0.1	-0.5
Blood Platelet Count	0.4	4.4	11.4	-3.4	0.3	1.5	-2.9	0.5
Blood Red Count	0.2	2.3	5.7	-2.3	-0.4	-0.3	2.4	0.4
Blood White Count	0.3	2.5	9.2	-3.0	-0.9	-0.9	-0.2	-1.2
Heel T-Score	0.4	3.1	9.9	-1.0	-0.9	-1.5	-1.3	-3.1
BMI	0.3	2.0	2.9	-1.2	1.6	-1.1	-1.4	1.7
Height	0.2	3.7	5.0	-2.2	2.0	-2.1	-2.2	0.5
Waist Hip Ratio (WHR)	1.4	6.1	21.0	-4.6	-2.2	1.0	-0.0	-1.9
Systolic Blood Pressure	0.2	0.9	3.1	-0.3	0.1	-0.1	1.8	1.0
Smoking Status	0.3	0.7	1.8	-0.2	-0.3	1.0	-1.4	-0.7
Allergy or Eczema	0.4	1.1	2.7	-1.6	-1.1	-0.0	1.1	-0.5
Cardiovascular Disease	0.9	2.9	6.0	-2.4	-1.6	1.9	-0.8	-1.2
Hypothyroidism (self reported)	0.4	0.9	1.7	1.2	-1.3	-0.4	0.2	-1.1
Respiratory disease	0.3	0.7	1.5	-0.6	1.2	0.2	-0.5	1.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.8	-0.7	-0.0	-0.9	-1.7	-1.0
Lung FEV1/FVC ratio	1.0	4.9	12.5	-3.5	0.1	-1.1	-3.0	-1.2
Lung FVC	1.6	8.1	27.7	3.6	-0.2	-5.3	0.1	-0.2
Neuroticism	0.5	1.3	1.8	1.2	1.4	-1.1	-1.1	1.0
Chronotype (morning person)	1.0	2.3	6.0	-2.4	-1.3	1.4	-0.5	-1.3
Hair Pigment	0.0	0.3	0.4	-0.4	0.6	0.3	-0.6	0.7
Tanning	0.3	3.1	6.8	1.3	-2.0	-1.1	-1.3	-2.6
Hand grip strength (left)	0.6	1.5	3.8	0.2	2.0	-0.6	-0.1	1.9
Number of treatments/medications taken	1.2	2.1	4.4	-1.9	1.1	0.7	-2.1	0.9
Average weekly spirits intake	0.8	0.9	2.6	0.6	-0.2	1.1	-1.6	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.8	0.2	0.8	-0.1	-0.0	1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.8	0.3	-0.6	-0.7	0.1
Hearing difficulty/problems: Yes	0.7	1.0	2.3	-0.4	0.8	1.3	-1.5	0.6
Relative age of first facial hair	1.5	3.2	11.7	3.4	-0.1	-0.7	-1.5	-1.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	4.3	1.7	0.0	2.1	0.4	-0.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.8	0.3	2.0	0.2	0.4	2.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	0.0	-1.2	0.7	0.4	-0.9
Systolic blood pressure, automated reading	0.2	0.7	2.1	-1.4	0.8	-0.3	-0.2	0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	0.5	0.8	-1.4	-0.5	0.7
Angina	0.3	0.4	0.5	0.7	-0.6	0.7	0.4	-0.5
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.2	0.7	-0.3	0.2	0.5
Vitamin and mineral supplements	1.3	1.7	4.4	-0.3	1.8	0.8	-0.5	2.1
Supplements: Zinc	0.7	0.7	2.1	-0.2	0.8	-1.5	-0.7	0.5
Medication: Co-codamol	1.1	1.3	2.7	-1.6	0.8	-1.0	-1.6	0.1
Medication: Metformin	1.1	1.6	4.3	-1.1	0.4	-1.5	-2.1	-0.3
Diabetes (father)	2.3	2.9	6.6	-2.5	0.1	-0.7	-2.6	-0.8
Diabetes (mother)	0.6	0.8	2.0	1.4	0.6	0.2	0.9	0.8
Severe depression (siblings)	0.6	0.7	1.2	0.2	1.1	-0.8	0.7	1.0
Pack years adult smoking proportion	0.5	0.8	2.2	-0.0	-0.9	1.5	0.0	-1.0
Impedance of leg (right)	0.9	4.1	6.7	-1.6	-2.6	1.7	1.5	-2.5
Leg fat-free mass (left)	1.0	5.2	9.8	0.2	3.1	-1.9	-2.0	3.0
Trunk fat percentage	0.2	1.0	2.4	-1.5	0.0	0.4	-1.6	-0.1
Hand grip strength (right)	0.4	1.0	2.1	0.6	1.4	-0.8	0.2	1.3
Townsend deprivation index at recruitment	0.4	0.6	1.1	0.3	-0.9	0.4	-0.9	-1.0
Current tobacco smoking	0.6	1.0	1.9	0.9	-1.0	1.4	-0.2	-1.1
Average weekly fortified wine intake	0.7	0.9	2.0	-0.3	-0.9	1.1	0.2	-1.4
Maternal smoking around birth	0.9	1.3	3.1	-0.3	1.5	-0.5	-1.8	0.9
Fed-up feelings	0.4	0.6	2.0	1.0	0.0	-1.4	-0.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.4	-0.1	-0.2	-1.5	-1.0	-0.7
Relative age voice broke	0.8	1.2	3.4	1.8	0.2	-1.0	-1.1	-0.4
Taking other prescription medications	1.1	1.7	4.2	-1.5	0.0	1.4	-2.0	0.3
Age when periods started (menarche)	1.3	3.0	5.1	2.3	-1.8	-1.0	1.3	-2.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	-0.9	0.1	-0.1	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	5.0	-1.6	-1.1	-1.6	-0.6	-2.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.5	0.7	1.0	-0.0	0.3	1.2
Qualifications: CSEs or equivalent	1.0	1.3	2.6	0.3	1.2	0.7	-1.6	1.3
Serious illness, injury or assault to yourself	1.2	1.5	2.2	1.0	1.5	1.2	0.7	1.4
High blood pressure	0.3	0.9	3.1	-1.8	-0.6	0.1	-1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.5	-1.2	-0.4	-0.4	0.8	-0.2
Multivitamins +/- minerals	2.5	3.1	8.1	-0.6	-2.6	-0.0	0.5	-2.8
Stomach or abdominal pain in last month	4.1	5.1	15.9	-1.5	2.2	0.3	-4.0	1.5
Supplements: Glucosamine	0.8	1.0	1.8	-0.1	-1.3	-0.5	1.3	-1.1
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	6.2	-2.5	-1.7	0.2	-0.9	-1.6
Medication: Atenolol	1.0	1.3	2.7	-1.5	-0.7	0.5	-1.6	-0.7
Medication: Levothyroxine sodium	0.7	1.1	2.4	0.9	-1.6	-0.7	1.2	-0.7
Sitting height	0.3	1.9	4.8	0.2	2.0	0.3	0.5	2.2
Chronic bronchitis/emphysema (father)	1.3	1.5	3.7	1.6	0.3	-1.9	1.0	-0.2
High blood pressure (mother)	1.2	1.6	2.5	0.4	1.4	1.6	-1.3	1.4
Body mass index (BMI)	0.5	2.0	4.1	-0.4	1.8	-0.6	-1.6	2.0
Impedance of leg (left)	1.3	6.2	10.2	-1.6	-3.2	2.6	1.6	-3.0
Leg predicted mass (left)	1.0	5.2	10.0	0.2	3.2	-1.8	-2.0	3.0
Trunk fat mass	0.3	1.5	3.6	-1.4	1.0	-0.2	-1.9	0.8
Waist circumference	0.5	1.7	4.7	-2.2	0.9	-0.1	-1.2	1.2
Number of incorrect matches in round	0.3	0.5	1.4	0.6	-0.7	0.2	1.2	-0.1
Past tobacco smoking	0.2	0.4	0.7	-0.2	0.6	0.2	0.9	0.8
Alcohol usually taken with meals	0.4	0.7	2.4	-0.1	0.6	1.6	0.5	0.7
Nervous feelings	0.1	0.2	0.9	0.3	-0.0	-1.0	0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.4	0.8	-0.0	0.7	1.2	0.0
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.4	0.4	0.9	-0.7	0.2
Hair/balding pattern: Pattern 2	0.9	1.1	4.1	-0.6	1.0	-0.1	-2.0	0.4
Had menopause	0.7	0.9	2.3	0.4	1.0	-1.5	-0.9	0.6
Had other major operations	0.8	0.9	3.6	0.8	0.4	0.4	-1.9	-0.0
Forced vital capacity (FVC)	0.9	3.3	12.1	1.8	0.7	-3.5	-0.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	-0.6	-0.4	-1.2	-0.9	-1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.2	0.2	-1.1	0.0	-0.6	-1.5
Qualifications: None of the above	0.5	1.0	2.0	-1.0	-0.4	1.4	1.3	0.5
Financial difficulties in last 2 years	0.2	0.3	1.0	0.7	0.1	-0.1	1.0	0.2
Mouth/teeth dental problems	0.1	0.1	0.4	0.7	-0.1	0.3	0.1	-0.4
Heart attack	1.5	1.9	3.0	-0.6	1.7	1.5	-1.2	1.6
Allergy	0.3	0.7	1.6	0.6	-1.3	0.4	0.4	-1.1
Pain all over the body in last month	0.4	0.4	1.3	-0.2	-0.1	1.1	-0.8	-0.4
Diabetes (self-reported)	1.7	2.7	6.9	0.3	0.8	-2.3	-2.6	-0.7
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	9.0	-3.0	-0.0	0.5	0.7	0.7
Medication: Ramipril	0.5	0.6	1.5	-0.2	-0.6	0.4	-1.2	-1.1
Medication: Simvastatin	0.7	1.1	3.0	0.0	0.2	1.7	-1.5	-0.4
Fluid intelligence score	0.8	1.6	5.0	2.2	-0.4	-1.4	0.2	-0.9
Illnesses of siblings	0.0	0.0	0.1	0.0	-0.3	0.0	0.2	-0.4
Neuroticism score	0.8	1.8	2.8	1.5	1.7	-0.2	-1.2	1.6
Weight	0.6	2.7	4.9	-0.9	2.2	-0.9	-1.6	2.2
Impedance of arm (right)	1.4	6.4	16.8	-1.1	-3.5	1.2	0.4	-4.1
Arm fat percentage (right)	0.2	0.8	2.7	-1.1	0.3	0.2	-1.6	0.2
Trunk fat-free mass	1.1	6.1	12.7	-0.6	3.4	-1.9	-1.3	3.6
Hip circumference	0.2	0.9	2.4	0.4	1.3	-0.3	-0.6	1.5
Time employed in main current job	2.1	2.4	5.5	2.4	1.4	-1.7	-0.1	1.2
Alcohol intake versus 10 years previously	1.4	2.1	5.6	-2.4	-1.2	0.7	-1.1	-1.2
Father’s age at death	0.2	0.2	0.5	0.4	0.5	-0.7	0.3	0.5
Worrier / anxious feelings	0.5	0.9	1.6	1.0	1.1	-0.4	-1.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.1	0.7	-0.7	-0.3	0.8
Falls in the last year	0.9	1.2	2.5	-0.2	-1.6	-0.6	1.1	-1.4
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.3	-0.6	-0.5	0.9	-0.6
Number of live births	0.5	0.7	2.4	-0.1	-1.0	-0.2	1.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	13.3	0.6	0.8	-3.6	-1.3	0.1
Pulse rate	0.3	0.4	2.0	-0.0	-0.3	0.2	1.4	0.1
Happiness	0.2	0.3	1.1	0.4	0.3	-1.0	-0.4	0.3
Noisy workplace	0.8	1.0	1.5	-0.8	1.2	-0.7	-1.1	0.9
Qualifications: A levels/AS levels or equivalent	1.3	2.9	3.8	1.6	1.6	-1.6	2.0	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.6	1.3	-0.8	1.2	1.2	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.6	-0.2
Asthma	0.5	0.9	1.9	-0.7	1.0	0.3	-1.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.8	1.5	1.9	-0.7	0.4	1.9
Medication: Cholesterol lowering	1.7	2.7	5.4	-0.5	-1.6	2.3	-1.2	-1.9
Depression (self-reported)	0.7	0.8	2.0	0.1	1.1	-0.7	-1.4	0.7
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.2	0.4	0.5	-0.2
Prospective memory result	0.1	0.1	0.3	-0.1	0.1	0.2	0.3	0.6
Lung cancer (father)	1.4	1.6	3.5	-0.8	1.9	-0.5	-0.6	1.8
Illnesses of mother	0.4	0.4	1.2	-0.7	-0.1	-1.1	0.7	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	10.9	0.7	0.3	-3.3	-0.8	-0.2
Pulse wave Arterial Stiffness index	2.2	2.6	5.8	-1.4	2.1	-0.8	0.1	2.4
Impedance of arm (left)	1.1	5.0	13.8	-1.1	-3.1	0.7	0.2	-3.7
Arm fat mass (right)	0.4	1.8	3.3	-1.0	1.5	-0.2	-1.8	1.6
Trunk predicted mass	1.0	5.9	12.2	-0.6	3.4	-2.0	-1.2	3.5
Standing height	0.1	0.9	1.6	-1.2	1.2	-0.9	-0.2	0.9
Length of working week for main job	3.0	3.3	5.8	2.4	0.6	2.3	1.4	1.8
Exposure to tobacco smoke at home	0.7	0.8	1.2	1.1	1.1	-0.6	-0.7	0.8
Breastfed as a baby	2.0	2.4	9.5	3.1	0.3	-1.5	0.4	-0.3
Tense / ‘highly strung’	1.2	1.9	4.7	1.2	2.2	-0.4	-0.1	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	3.4	1.8	0.1	0.8	0.3	0.3
Hair/balding pattern: Pattern 4	0.1	0.4	0.6	-0.6	-0.8	-0.2	0.7	-0.7
Birth weight of first child	0.6	1.1	3.9	-0.7	-0.8	0.4	2.0	0.0
Peak expiratory flow (PEF)	0.8	1.9	4.1	1.5	0.5	-2.0	-1.6	-0.1
Pulse wave reflection index	0.8	1.0	1.7	-1.0	1.1	-1.3	-0.5	0.9
Ever highly irritable/argumentative for 2 days	1.8	2.2	7.8	0.1	0.4	-1.6	-2.8	-0.7
Loud music exposure frequency	0.2	0.2	0.3	-0.2	0.6	0.5	-0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.6	0.7	1.4	-1.0	-1.6	0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	-1.3	-0.1	0.1	-0.4	0.4
Blood clot in the leg (DVT)	2.2	2.8	4.4	0.7	2.1	-1.9	-2.0	1.3
Medication: Paracetamol	0.6	0.9	1.7	-0.2	1.3	-1.1	-0.7	1.2
Headache pain in last month	0.6	1.0	2.5	1.6	0.1	-1.5	0.1	0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	3.8	1.9	1.0	-0.2	1.9	1.6
Glaucoma (self-reported)	1.7	2.0	5.3	-0.5	-2.0	0.8	-0.0	-2.3
Gout (self-reported)	0.5	0.6	2.4	0.2	0.5	-1.6	-0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	0.8	-0.4	-0.6	-0.5	-0.1
Medication: Amlodipine	0.1	0.2	0.3	-0.2	0.5	-0.6	-0.6	0.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.9	-1.7	0.4	-0.5	-1.2	0.3
Birth weight	0.5	1.0	4.5	-2.1	0.4	-0.1	0.5	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.6	-0.5	-1.2	-0.4	-0.8
High blood pressure (siblings)	0.4	0.5	1.7	-0.9	0.3	0.1	-1.3	0.1
Forced vital capacity (FVC), Best measure	0.8	2.9	10.0	1.9	0.5	-3.2	-0.6	0.1
Body fat percentage	0.2	0.8	2.3	-1.2	0.1	0.2	-1.5	-0.0
Leg fat percentage (right)	0.1	0.4	0.9	-0.7	0.4	-0.1	-0.9	0.5
Arm fat-free mass (right)	1.3	6.7	16.2	-0.3	3.6	-1.6	-1.2	4.0
Exposure to tobacco smoke outside home	1.1	1.5	2.9	1.7	1.4	1.2	0.3	1.1
Comparative body size at age 10	0.7	2.0	4.1	1.5	2.0	-0.4	-0.7	1.8
Number of full brothers	0.2	0.3	1.0	-0.5	0.2	-0.0	1.0	0.4
Worry too long after embarrassment	0.7	1.2	2.6	1.2	1.4	-0.1	0.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.3	1.0	-0.5	1.1	0.1	-0.7
Wheeze or whistling in the chest in last year	0.4	0.8	2.0	0.2	0.9	1.0	0.4	1.4
Number of children fathered	0.2	0.2	0.4	-0.2	-0.6	-0.2	-0.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	4.1	4.8	9.5	-0.1	-3.1	0.8	3.0	-2.2
Age at first live birth	0.1	0.1	0.3	-0.0	0.0	-0.5	0.5	0.3
Pulse wave peak to peak time	2.2	2.6	6.0	1.5	-2.1	0.6	-0.0	-2.5
Health satisfaction	0.9	1.2	3.2	-1.1	1.0	-0.5	-1.8	0.5
Shortness of breath walking on level ground	1.9	2.2	6.5	-1.8	1.1	-0.3	-2.5	0.3
Qualifications: College or University degree	0.5	1.4	3.8	1.3	0.3	1.1	1.9	0.5
Eye problems/disorders: None of the above	1.0	1.2	2.9	1.5	0.1	0.5	1.7	0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.7	-1.3	-1.0	1.3	0.8	-0.7
Emphysema/chronic bronchitis	2.0	2.2	3.8	-1.6	-1.4	1.9	1.4	-1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	1.8	0.1	-1.3	-1.0	0.8	-1.3
Neck or shoulder pain in last month	1.5	2.1	4.7	2.2	0.8	-2.2	-0.2	0.6
Medication: Blood pressure	0.7	1.2	3.1	-1.8	0.2	-0.6	-1.5	-0.4
Angina (self-reported)	0.2	0.2	0.3	0.5	-0.6	0.6	0.4	-0.4
Migraine (self-reported)	1.5	1.9	4.1	-0.5	1.5	-1.4	-2.0	1.1
Medication: Ibuprofen	1.5	1.8	4.2	0.9	2.1	-0.8	0.1	1.8
Medication: Allopurinol	1.3	1.7	7.7	0.5	0.2	-2.8	-0.8	-0.4
Medication: Omeprazole	1.8	2.1	4.6	-1.9	-0.7	0.4	-2.1	-1.3
Medication: Seretide 50 evohaler	1.8	2.1	3.9	-1.7	1.8	-0.0	0.6	2.0
Mean time to correctly identify matches	0.2	0.4	1.0	0.4	-0.4	-1.0	-0.6	-0.6
Heart disease (mother)	1.3	1.6	3.2	-0.4	1.8	0.7	-1.2	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	0.1	1.1	0.9	-1.3	0.6
Whole body fat mass	0.4	1.6	4.1	-1.2	1.1	-0.3	-2.0	0.9
Leg fat mass (right)	0.4	1.5	3.1	-0.7	1.4	-0.5	-1.8	1.4
Arm predicted mass (right)	1.2	6.3	15.4	-0.2	3.6	-1.2	-1.4	3.9
Pulse rate, automated reading	0.1	0.4	1.0	-1.0	0.5	-0.2	-0.1	0.8
Alcohol intake frequency.	0.8	1.9	8.7	0.2	-0.4	3.0	-0.9	-0.2
Comparative height size at age 10	0.3	1.6	6.9	-2.6	-0.0	1.1	-0.2	-0.1
Number of full sisters	0.1	0.2	0.6	-0.5	-0.0	0.0	-0.8	-0.1
Suffer from ‘nerves’	0.3	0.5	1.4	-0.9	0.4	-0.2	-1.2	0.1
Overall health rating	0.1	0.3	0.7	-0.3	-0.1	0.8	-0.8	0.1
Chest pain or discomfort	0.9	1.3	3.9	-0.8	0.8	1.0	-2.0	0.2
Had major operations	0.9	1.0	2.2	0.3	-1.5	1.2	-0.2	-1.1
Age at last live birth	0.9	1.3	3.8	1.1	-1.0	0.5	2.0	-0.3
Family relationship satisfaction	0.4	0.5	2.1	1.5	0.1	-0.1	-0.5	0.1
Leg pain on walking	1.1	1.4	4.4	-2.1	-0.4	0.9	-0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.9	-0.6	-0.0	1.0	-1.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	-0.3	1.2	0.7	-0.9	1.6
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.7	-2.1	0.3	0.2	-2.2	0.0
Medication: Aspirin	0.1	0.2	0.5	0.2	-0.0	0.7	-0.5	-0.3
Supplements: Vitamin C	0.3	0.3	1.1	0.0	0.5	-1.0	-0.4	0.2
Knee pain experienced in last month	0.7	1.1	2.7	-0.6	0.8	-0.5	-1.7	1.2
Hypertension (Self-reported)	0.4	1.0	3.1	-1.8	-0.8	-0.0	-1.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.7	-1.1	1.3	-0.6	-1.1	0.9
Illnesses of father: Heart disease	0.4	0.5	1.8	1.3	0.1	0.8	0.2	0.1
Illnesses of siblings: Diabetes	1.2	1.5	4.8	0.1	1.2	-0.3	-2.2	1.2
Smoking status: Previous	0.3	0.5	1.0	-0.9	-0.3	-0.6	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.1	0.2	0.7	-0.2	0.1	1.0
Whole body fat-free mass	1.0	5.5	11.4	-0.3	3.3	-1.7	-1.5	3.4
Leg fat-free mass (right)	0.8	4.1	7.8	0.5	2.8	-1.4	-1.9	2.6
Arm fat percentage (left)	0.2	1.0	3.3	-1.0	0.6	-0.3	-1.8	0.5
Average weekly red wine intake	0.8	1.2	4.1	0.7	0.6	-0.1	2.0	0.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.8	1.6	1.7	-0.4	-0.9	0.8
Mood swings	0.1	0.2	0.5	0.7	0.2	-0.1	-0.5	0.6
Loneliness, isolation	0.1	0.1	0.2	0.5	0.2	-0.2	-0.3	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.3	0.0	0.6	0.0	0.1
Ever had bowel cancer screening	2.2	2.6	5.3	-1.0	2.3	0.4	-2.2	1.2
Diabetes diagnosed by doctor	1.6	2.6	6.3	0.6	1.2	-2.3	-2.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	-0.6	-0.2	-1.0	-0.9	-1.1
Friendships satisfaction	0.4	0.6	2.1	1.5	-0.3	0.0	-0.7	-0.3
Qualifications: nursing, teaching	0.8	1.2	3.5	0.0	1.9	-0.6	-0.3	1.4
Commuting to job workplace: Walk	0.1	0.1	0.3	0.1	0.4	-0.5	-0.3	-0.0
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.7	-0.1	-0.4	-1.3	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.7	0.2	-0.3	0.8	0.6	-0.1
Medication for cholesterol	1.1	1.6	4.0	0.4	-0.9	-2.0	0.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.6	-0.6	-1.1	0.4	-0.7
Back pain experienced in last month	0.1	0.2	0.6	-0.4	-0.2	0.7	0.3	0.3
Mineral and other dietary supplements	1.2	1.7	3.3	1.8	1.5	0.7	-0.4	1.4
Breast cancer (self-reported)	0.3	0.4	0.9	0.2	0.8	0.5	-0.9	0.3
Asthma (self-reported)	0.6	1.1	2.2	-1.0	1.1	0.3	-1.5	1.1
Osteoporosis (self-reported)	0.3	0.4	1.3	0.7	0.4	-1.1	-0.1	0.2
Osteoarthritis (self-reported)	3.4	4.4	21.5	-4.6	-0.0	0.3	0.3	0.5
Medication: Aspirin	0.3	0.3	1.4	0.1	0.3	0.4	-1.2	-0.3
Medication: Gliclazide	0.8	0.9	1.7	-0.0	-0.4	-1.1	-1.3	-1.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.2	-0.6
Smoking status: Current	0.7	1.1	2.9	1.0	-0.9	1.7	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	7.1	-0.4	0.5	-2.7	-0.8	0.3
Whole body water mass	1.0	5.6	11.7	-0.2	3.3	-1.8	-1.5	3.4
Leg predicted mass (right)	0.8	4.2	7.9	0.6	2.8	-1.4	-1.8	2.7
Arm fat mass (left)	0.5	2.2	3.7	-1.1	1.7	-0.4	-1.9	1.7
Number of self-reported non-cancer illnesses	2.0	3.5	10.9	-3.3	-0.0	2.1	-1.3	0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.0	0.4	0.4	-0.9	1.0	0.2
Miserableness	0.9	1.5	2.7	0.9	-1.6	0.2	-1.2	-1.6
Guilty feelings	0.4	0.7	1.5	1.2	0.6	1.0	-0.3	0.6
Wears glasses or contact lenses	0.4	0.5	0.9	0.2	-1.0	0.2	0.7	-0.9
Ever taken oral contraceptive pill	1.3	1.4	2.9	-1.5	-1.0	-1.7	-0.4	-0.8
Hearing aid user	0.3	0.4	0.8	-0.6	-0.9	-0.2	-0.4	-0.7
Mother’s age at death	0.6	0.7	2.9	0.6	0.6	-1.7	0.1	-0.3
Financial situation satisfaction	0.8	1.0	2.4	-0.1	1.0	-1.1	-1.6	0.7
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.0	0.2	0.0	-0.0	0.1
Commuting to job workplace: Public transport	2.9	3.4	8.2	-0.0	-2.7	-0.9	0.9	-2.9
Eye problems/disorders: Glaucoma	0.8	1.0	2.5	-0.5	-1.4	0.4	-0.2	-1.6
Medication: Blood pressure	0.3	0.7	2.5	-0.3	-0.7	1.6	0.1	0.3
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.2	-1.3	1.7	1.0	0.5	2.1
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.9	-1.2	-2.0	-0.8	1.2	-1.7
High cholesterol (Self-reported)	1.7	3.0	8.6	-1.8	-0.8	2.9	-1.4	-0.9
Medication: Bendroflumethiazide	0.3	0.4	1.2	0.1	0.1	-0.9	-1.1	-0.0
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.4	-0.1	-0.7	0.4
Medication: Lisinopril	0.6	0.8	1.4	1.2	-1.0	-0.9	-0.2	-0.9
Medication: Atorvastatin	1.1	1.4	4.0	0.4	-1.1	2.0	-0.0	-1.2
Illnesses of father: High blood pressure	1.4	1.7	3.4	1.2	1.8	-0.7	0.5	1.9
Alcohol drinker status: Never	0.4	0.5	1.3	-0.6	0.6	-0.2	-1.1	0.6
Ever smoked	0.5	0.8	1.8	0.6	-0.6	-0.7	-1.4	-1.0
Basal metabolic rate	0.9	5.0	10.2	-0.4	3.1	-1.5	-1.6	3.2
Leg fat percentage (left)	0.1	0.4	0.9	-0.7	0.2	0.5	-0.9	0.3
Arm fat-free mass (left)	1.0	4.9	13.0	-0.4	3.1	-1.1	-0.7	3.6
Number of operations (self-reported)	0.3	0.4	1.3	1.1	-0.5	0.3	-0.5	-0.6
Average weekly beer plus cider intake	0.5	0.7	1.1	-0.1	0.7	1.1	-0.9	1.1
Irritability	0.9	1.5	3.0	-0.1	1.7	-1.0	-1.5	1.2
Risk taking	1.3	1.9	3.9	0.2	1.2	1.0	2.0	1.8
Ever had prostate specific antigen (PSA) test	0.8	1.0	3.1	-1.1	-0.2	-0.2	-1.8	-0.7
Fractured/broken bones in last 5 years	0.6	0.7	1.6	0.6	-0.7	0.8	-1.2	-0.9
Age started oral contraceptive pill	0.4	0.4	0.9	-0.9	-0.8	0.5	0.3	-0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.6	-1.1	-0.7	-0.3	1.3	-0.1
Ever depressed for a whole week	0.2	0.3	0.9	0.4	-0.5	0.0	0.9	-0.5
Unable to work because of sickness or disability	0.7	1.0	2.1	0.5	-1.4	0.4	0.7	-1.4
Commuting to job workplace: Cycle	1.4	1.7	4.2	-0.1	-2.0	-0.6	-0.4	-2.0
Myopia	1.7	2.5	7.6	1.2	0.1	2.8	1.8	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.8	2.2	0.5	-0.9	0.9	0.1
Cholesterol lowering medication	1.0	1.5	2.5	1.0	1.3	1.6	-1.1	1.1
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.9	-1.9	-0.6	0.4	-2.4	-1.3
Pain experienced in last month	0.5	0.8	3.0	-0.3	-1.0	0.0	0.2	-1.7
Supplements: Calcium	1.2	1.3	2.6	0.3	1.2	-1.6	0.8	1.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.9	-0.1	1.7	-0.2	0.4	1.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.1	-0.5	1.5	1.4	-1.1	1.3
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	4.4	0.6	2.1	-2.1	-1.9	1.3
Heart disease (siblings)	0.7	0.8	1.7	-0.9	1.1	0.7	0.1	1.3
Alcohol drinker status: Previous	2.1	2.4	8.8	3.0	-0.5	1.5	0.8	-0.4
Pack years of smoking	0.4	0.6	1.5	-0.4	-0.7	1.2	0.2	-0.8
Impedance of whole body	1.3	6.6	13.0	-1.4	-3.5	1.9	1.5	-3.6
Leg fat mass (left)	0.3	1.3	2.8	-0.8	1.3	-0.0	-1.7	1.3
Arm predicted mass (left)	1.0	4.9	11.9	-0.8	3.0	-1.2	-1.0	3.5