Best TWAS P=1.41e-36 · Best GWAS P=6.32e-36 conditioned to 0.00217
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EFEMP1 | 0.31 | 0.08 | bslmm | 493 | 0.24 | 1.4e-28 | 8.4 | -6.3 | 3.2e-10 | 0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -12.1 | -11.0 | 5.6e-28 | 0.78 | 0.04 | 0.65 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CCDC88A | 0.06 | 0.01 | blup | 544 | 0.01 | 9.4e-03 | -2.7 | 6.1 | 1.0e-09 | -0.22 | 0.23 | 0.02 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -8.8 | -9.3 | 1.3e-20 | 0.64 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -12.5 | 12.6 | 1.4e-36 | -0.73 | 0.00 | 1.00 | TRUE |