[Hub]/) : Traits : Lung FVC : ← →

chr2:47,224,927-49,519,654

Best TWAS P=2.12e-17 · Best GWAS P=1.9e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	FOXN2	0.09	0.03	lasso	3	0.01	5.6e-02	-7.09	-7.3	2.2e-13	-0.48	0.17	0.30	FALSE
2	GTEx	Adrenal Gland	FOXN2	0.24	0.11	lasso	6	0.16	2.8e-06	6.36	-7.5	9.6e-14	-0.68	0.18	0.78	FALSE
3	GTEx	Artery Aorta	PPP1R21	0.19	0.06	lasso	4	0.07	6.3e-05	7.58	7.0	2.2e-12	0.84	0.01	0.99	FALSE
4	GTEx	Artery Tibial	MSH6	0.09	0.04	lasso	2	0.03	4.1e-03	-5.84	-5.7	1.1e-08	-0.15	0.11	0.81	FALSE
5	GTEx	Artery Tibial	PPP1R21	0.09	0.01	lasso	4	0.00	1.6e-01	-2.38	5.4	5.7e-08	0.69	0.04	0.81	FALSE
6	GTEx	Artery Tibial	FOXN2	0.05	0.03	enet	8	0.03	1.1e-03	-5.09	-5.7	1.0e-08	-0.25	0.20	0.11	FALSE
7	GTEx	Brain Cortex	RP11-191L17.1	0.27	0.02	lasso	4	0.04	2.3e-02	6.66	-7.9	2.8e-15	-0.78	0.05	0.71	FALSE
8	GTEx	Cells Transformed fibroblasts	PPP1R21	0.08	0.09	lasso	3	0.08	2.8e-06	7.65	7.5	6.0e-14	0.97	0.01	0.99	FALSE
9	GTEx	Cells Transformed fibroblasts	FOXN2	0.18	0.15	lasso	4	0.14	7.3e-11	-5.09	-5.9	3.6e-09	-0.31	1.00	0.00	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	STON1	0.41	0.42	lasso	2	0.41	2.7e-16	5.17	5.2	2.4e-07	0.43	1.00	0.00	FALSE
11	GTEx	Esophagus Mucosa	PPP1R21	0.16	0.07	enet	22	0.03	4.2e-03	7.66	7.0	2.9e-12	0.78	0.01	0.99	FALSE
12	GTEx	Esophagus Mucosa	STON1	0.09	0.14	lasso	1	0.13	6.9e-09	5.17	5.2	2.4e-07	0.43	0.99	0.00	FALSE
13	GTEx	Esophagus Muscularis	MSH6	0.11	0.03	enet	18	0.06	2.4e-04	-5.58	-6.4	2.0e-10	-0.34	0.11	0.43	FALSE
14	GTEx	Esophagus Muscularis	FOXN2	0.31	0.24	lasso	5	0.23	3.0e-14	-5.09	-5.7	9.4e-09	-0.30	1.00	0.00	FALSE
15	GTEx	Lung	MSH6	0.16	0.02	lasso	4	0.04	2.4e-04	-5.84	-6.0	1.5e-09	-0.37	0.11	0.84	FALSE
16	GTEx	Lung	FOXN2	0.37	0.24	lasso	5	0.24	2.5e-18	-5.09	-5.2	2.3e-07	-0.23	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	MSH6	0.13	0.03	lasso	5	0.05	1.0e-04	-5.58	-7.5	6.8e-14	-0.27	0.16	0.74	TRUE
18	GTEx	Nerve Tibial	FOXN2	0.46	0.38	enet	22	0.37	2.6e-27	-5.09	-5.8	8.9e-09	-0.25	1.00	0.00	FALSE
19	GTEx	Pancreas	FOXN2	0.23	0.12	lasso	2	0.07	6.7e-04	-5.09	-5.7	1.2e-08	-0.29	0.16	0.38	FALSE
20	GTEx	Pituitary	FOXN2	0.35	0.32	lasso	3	0.31	1.8e-08	-5.09	-5.9	3.8e-09	-0.32	0.58	0.14	FALSE
21	GTEx	Prostate	FOXN2	0.21	0.14	lasso	3	0.17	4.2e-05	-5.09	-5.4	8.2e-08	-0.24	0.16	0.16	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	PPP1R21	0.21	0.03	enet	76	0.03	1.1e-02	7.59	5.2	1.8e-07	0.55	0.01	0.97	FALSE
23	GTEx	Skin Sun Exposed Lower leg	MSH6	0.20	0.12	lasso	3	0.15	1.7e-12	4.36	-6.2	7.6e-10	-0.42	0.98	0.02	FALSE
24	GTEx	Testis	MSH6	0.26	0.19	lasso	2	0.19	1.0e-08	-5.84	-5.8	5.5e-09	-0.22	0.11	0.89	FALSE
25	GTEx	Testis	PPP1R21	0.30	0.15	enet	45	0.18	2.7e-08	5.73	5.8	4.8e-09	0.47	0.20	0.80	FALSE
26	GTEx	Testis	FOXN2	0.30	0.22	lasso	3	0.22	4.2e-10	-5.09	-6.0	1.6e-09	-0.32	0.98	0.01	TRUE
27	GTEx	Thyroid	MSH6	0.15	0.17	enet	12	0.16	3.5e-12	-5.84	-6.8	9.5e-12	-0.29	0.11	0.89	TRUE
28	GTEx	Thyroid	PPP1R21	0.46	0.38	enet	18	0.44	4.1e-37	7.37	6.5	7.4e-11	0.84	0.02	0.98	FALSE
29	GTEx	Thyroid	FOXN2	0.27	0.21	lasso	5	0.19	2.2e-14	-5.09	-5.2	2.4e-07	-0.22	1.00	0.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	PPP1R21	0.16	0.14	lasso	4	0.13	8.8e-17	5.98	6.2	5.3e-10	0.48	1.00	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	FOXN2	0.26	0.21	lasso	6	0.21	2.4e-26	-5.09	-5.9	4.7e-09	-0.39	1.00	0.00	FALSE
32	YFS	Blood	MSH6	0.10	0.04	lasso	7	0.08	2.0e-24	-5.84	-6.2	7.4e-10	-0.37	0.11	0.89	TRUE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GTF2A1L	0.35	0.19	lasso	1	0.18	2.1e-15	5.17	-5.2	2.4e-07	-0.43	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KLRAQ1	0.08	0.01	enet	14	0.03	9.2e-04	6.66	7.6	2.3e-14	0.65	0.01	0.71	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	FOXN2	0.01	0.01	blup	51	0.01	7.4e-03	6.43	-7.3	3.6e-13	-0.88	0.01	0.92	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	KLRAQ1	0.14	0.01	enet	14	0.04	6.3e-08	7.61	5.6	1.7e-08	0.51	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSH6	0.05	0.03	enet	12	0.06	1.1e-11	4.33	-7.0	1.9e-12	-0.44	0.07	0.93	TRUE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	KLRAQ1	0.18	0.01	enet	11	0.10	1.4e-06	7.61	6.8	7.6e-12	0.57	0.01	0.79	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	KLRAQ1	0.15	0.01	blup	57	0.08	2.4e-03	7.53	6.3	2.5e-10	0.85	0.01	0.59	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KLRAQ1	0.15	0.08	lasso	7	0.13	3.6e-14	6.51	6.8	1.5e-11	0.76	0.25	0.75	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STON1-GTF2A1L	0.16	0.15	enet	18	0.14	3.8e-15	5.17	-5.2	2.0e-07	-0.49	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KLRAQ1	0.04	0.00	blup	56	0.03	5.4e-04	0.93	6.0	2.1e-09	0.71	0.03	0.82	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MSH6	0.07	0.02	blup	26	0.06	6.2e-07	-2.47	-5.3	1.3e-07	-0.20	0.00	0.98	FALSE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KLRAQ1	0.05	0.02	blup	50	0.04	2.6e-03	-4.81	7.0	2.9e-12	0.76	0.02	0.81	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	FOXN2	0.05	0.04	blup	52	0.03	4.0e-04	6.32	-6.4	1.2e-10	-0.63	0.36	0.17	TRUE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	GTF2A1L	0.32	0.27	lasso	2	0.27	7.1e-31	5.17	-5.2	2.4e-07	-0.43	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLRAQ1	0.03	0.01	blup	49	0.02	4.7e-03	5.98	8.5	2.6e-17	0.66	0.03	0.66	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	MSH6	0.03	0.01	blup	26	0.01	1.5e-02	-5.88	-5.6	2.0e-08	-0.11	0.00	0.98	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	STON1-GTF2A1L	0.34	0.28	lasso	3	0.27	4.0e-31	5.17	-5.2	2.5e-07	-0.43	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GTF2A1L	0.26	0.18	lasso	1	0.14	3.5e-07	5.17	-5.2	2.4e-07	-0.43	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	GTF2A1L	0.26	0.22	lasso	2	0.22	1.0e-24	5.17	-5.2	2.5e-07	-0.43	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	KLRAQ1	0.03	0.00	blup	50	0.01	9.5e-03	3.60	6.0	2.2e-09	0.77	0.02	0.73	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STON1-GTF2A1L	0.22	0.20	lasso	1	0.20	2.2e-22	5.17	-5.2	2.4e-07	-0.43	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GTF2A1L	0.21	0.20	lasso	1	0.20	3.2e-13	5.17	-5.2	2.4e-07	-0.43	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KLRAQ1	0.15	0.04	lasso	5	0.04	6.9e-04	-4.72	5.5	3.9e-08	0.63	0.04	0.88	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FOXN2	0.08	0.02	blup	52	0.06	2.0e-03	6.50	-7.5	4.3e-14	-0.86	0.02	0.81	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GTF2A1L	0.51	0.39	lasso	2	0.39	2.8e-17	5.17	-5.1	2.7e-07	-0.44	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	STON1	0.15	0.03	blup	73	0.05	4.2e-03	5.67	6.7	2.0e-11	0.31	0.03	0.12	TRUE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	KLRAQ1	0.11	0.00	blup	49	0.05	6.4e-03	5.91	7.6	3.1e-14	0.63	0.06	0.72	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	KLRAQ1	0.35	0.06	enet	19	0.16	1.2e-16	7.37	8.5	2.1e-17	0.65	0.00	1.00	TRUE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	MSH6	0.05	0.03	blup	26	0.02	7.6e-03	-5.84	-7.1	9.3e-13	-0.35	0.00	0.98	TRUE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	STON1-GTF2A1L	0.44	0.38	lasso	1	0.38	1.1e-41	5.17	-5.2	2.4e-07	-0.43	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Rectum Adenocarcinoma	GTF2A1L	0.43	0.44	lasso	2	0.42	6.0e-11	5.17	-5.3	9.1e-08	-0.44	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	STON1-GTF2A1L	0.14	0.14	lasso	1	0.14	4.5e-10	5.17	-5.2	2.4e-07	-0.43	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	FOXN2	0.04	0.01	blup	52	0.02	2.1e-03	7.65	-8.0	1.0e-15	-0.87	0.01	0.96	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	KLRAQ1	0.30	0.20	blup	63	0.20	3.8e-19	3.96	5.9	3.2e-09	0.73	0.14	0.86	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	MSH6	0.11	0.06	enet	6	0.12	5.3e-12	-5.84	-6.9	5.7e-12	-0.28	0.00	1.00	TRUE