Hub : Genes

CCDC88A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1580	0.0600	0.0031	0.012	NA	-0.005	NA	0.004	5.8e-02	NA	9.4e-01	NA	1.8e-01
2	GTEx	Spleen	0.2930	0.0980	0.0024	0.090	NA	0.014	NA	0.042	2.6e-03	NA	1.4e-01	NA	3.1e-02
3	GTEx	Testis	0.4880	0.0580	0.0000	0.369	NA	0.565	NA	0.555	2.5e-17	NA	7.1e-30	NA	4.7e-29
4	ROSMAP	Brain Pre-frontal Cortex	0.0582	0.0277	0.0085	0.008	0.012	0.002	0.01	0.004	2.7e-02	0.0094	1.9e-01	0.015	8.4e-02
5	TCGA	Liver Hepatocellular Carcinoma	0.0790	0.0430	0.0013	0.008	0.052	0.019	NA	0.037	1.2e-01	0.0019	4.2e-02	NA	7.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.9	0.5	-0.4	0.3	-0.9	0.4
Bipolar Disorder or Schizophrenia	0.7	1.7	6.4	1.3	-0.8	0.0	-2.5	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	2.4	0.9	1.5	-0.7	-1.3	-0.6
Depression (Nagel 2018)	0.5	0.8	3.0	0.3	0.0	0.3	-1.7	0.8
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.5	-1.1	-1.7	1.9	0.5	1.6
Neuroticism (Nagel 2018)	0.8	2.0	5.7	2.4	1.5	-0.3	-1.3	0.4
Schizophrenia (2018)	0.8	1.7	6.2	1.3	-0.7	-0.2	-2.5	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.7	-0.5	0.2	-0.2	0.5
Worry (Nagel 2018)	0.6	1.4	3.9	2.0	0.9	-0.3	-1.3	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	0.1	0.8	0.0	0.9	0.6
Alzheimer’s Disease (in father)	1.3	1.4	2.5	-1.4	1.6	-1.2	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.2	0.4	1.3	-0.3	1.1	-0.6	0.2	0.1
Crohns Disease (2017)	0.8	1.7	5.2	2.3	1.2	-0.9	0.6	-0.8
Irritable Bowel Disease (IBD)	0.2	0.5	2.2	1.5	0.3	-0.4	0.5	-0.2
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.5	-0.4	-0.2	0.0	-0.0
Major Depression (MDD)	1.3	1.6	6.4	-0.5	-1.0	0.4	-2.5	0.4
Reaction Time	0.9	1.7	3.8	-0.8	-1.9	1.0	0.5	1.7
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.2	-0.4	-1.4	2.1	0.1	1.9
Breast Cancer	0.8	1.9	6.9	-2.6	-1.0	0.9	0.3	0.7
Ovarian Cancer	0.2	0.2	0.9	-0.1	-0.3	-0.4	-0.9	-0.0
Prostate Cancer	0.1	0.1	0.3	-0.5	-0.3	0.1	0.3	-0.1
Age at First Birth	3.6	5.2	11.4	-1.1	-3.4	2.3	0.9	2.7
Bipolar Disorder (2011)	0.9	0.9	2.4	1.5	-0.4	0.8	-0.8	0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.5	-0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.0	1.0	0.7	-0.1	-0.2	-0.9
Crohns Disease (2012)	0.2	0.3	0.6	0.4	-0.7	-0.1	0.8	0.2
Mean Putamen Volume	0.7	0.8	2.3	0.8	1.5	-0.8	0.5	-0.5
Fasting Glucose	1.4	1.7	3.0	1.7	0.6	-1.4	-1.4	-1.0
HbA1C	3.0	3.3	11.5	1.2	0.6	-1.5	-3.4	-1.1
HDL Cholesterol	0.1	0.1	0.3	0.5	0.2	0.1	-0.5	0.1
LDL Cholesterol	0.5	0.7	1.5	-1.2	-0.8	-0.7	-0.8	-0.7
Lupus	1.7	2.6	4.3	-0.7	-2.1	2.1	1.7	1.0
Neuroticism (2016)	0.9	1.4	3.4	1.8	1.7	-0.5	-0.5	-0.1
Primary Biliary Cirrhosis	0.9	1.3	3.2	-1.2	0.4	-1.3	-0.6	-1.8
Rheumatoid Arthritis	1.4	1.9	6.9	-0.0	1.1	-1.3	-0.1	-2.6
Schizophrenia (2014)	0.7	1.6	6.1	1.0	-0.9	0.1	-2.5	-0.2
Triglycerides	0.3	0.5	0.9	0.8	0.3	-1.0	0.8	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	1.3	0.9	0.2	1.4	-0.1
Ulcerative Colitis	0.8	1.2	3.5	-1.1	-1.9	0.8	0.2	0.8
Blood Eosinophil Count	1.0	7.8	15.0	0.8	2.7	-3.8	-1.3	-3.9
Blood Platelet Count	0.6	6.5	15.9	-4.0	1.0	-2.7	0.4	-2.8
Blood Red Count	0.0	0.4	1.4	0.4	0.2	-0.5	-0.6	-1.2
Blood White Count	0.8	6.2	10.1	1.8	2.2	-3.2	-1.9	-3.1
Heel T-Score	1.6	12.9	40.1	-6.3	-2.7	0.1	3.8	1.6
BMI	0.4	2.5	5.9	0.3	-1.9	1.2	-2.4	1.1
Height	0.4	8.1	15.5	1.0	-2.5	2.6	3.9	3.3
Waist Hip Ratio (WHR)	0.5	2.3	6.4	2.5	1.8	0.1	1.3	-0.3
Systolic Blood Pressure	0.8	3.9	6.5	-0.6	2.5	-1.7	-2.0	-2.4
Smoking Status	0.9	2.2	7.4	1.4	2.7	-0.7	-0.1	-1.0
Allergy or Eczema	0.5	1.2	3.2	-1.8	-1.2	0.9	0.7	-0.0
Cardiovascular Disease	0.2	0.8	2.2	-0.1	1.5	-0.5	-0.1	-1.2
Hypothyroidism (self reported)	0.7	1.7	4.8	0.1	2.2	-1.3	0.8	-1.2
Respiratory disease	1.3	2.9	5.4	0.7	2.0	-1.8	-1.2	-2.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.1	1.0	1.8	-0.9	0.1	-1.0
Lung FEV1/FVC ratio	1.2	6.0	9.9	0.2	-3.1	2.3	-2.4	3.0
Lung FVC	1.7	8.8	37.3	-0.9	1.4	-1.0	6.1	-1.6
Neuroticism	0.7	1.8	4.6	2.1	1.4	-0.0	-1.4	0.7
Chronotype (morning person)	1.0	2.3	4.6	0.2	1.6	-1.9	-1.0	-2.1
Hair Pigment	0.1	2.7	8.5	-2.1	-0.0	0.8	2.9	0.1
Tanning	0.2	2.0	4.8	2.1	0.6	0.3	2.2	-0.5
Hand grip strength (left)	1.2	3.1	5.7	1.5	-2.4	1.6	1.6	1.5
Number of treatments/medications taken	0.8	1.4	2.3	0.3	1.4	-1.5	-1.0	-1.3
Average weekly spirits intake	1.5	1.9	4.3	0.3	1.7	-2.1	-0.7	-1.2
Sensitivity / hurt feelings	1.1	1.9	5.7	1.6	2.4	-1.0	0.0	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	0.4	0.7	0.2	-0.7	0.8
Hearing difficulty/problems: Yes	0.8	1.2	2.4	0.7	1.5	-1.5	-0.3	-0.9
Relative age of first facial hair	1.1	2.2	7.1	-2.7	-0.7	-0.5	-1.8	-0.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.7	1.6	-1.4	1.6	0.4	2.2
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.1	1.5	1.8	0.4	1.4	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.0	0.4	0.3	-0.2	0.5
Systolic blood pressure, automated reading	1.0	2.8	3.9	1.2	1.7	-1.4	-2.0	-1.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.4	0.4	0.2	-1.2	0.4	-0.7
Angina	0.4	0.6	1.2	0.3	-1.1	0.2	-0.6	1.1
Medication for hormone replacement therapy	1.2	1.4	2.3	1.0	-0.2	1.3	1.5	1.4
Vitamin and mineral supplements	0.8	1.0	1.6	-1.3	-0.2	-1.2	-1.0	-1.0
Supplements: Zinc	1.4	1.5	2.6	0.8	-1.6	1.5	-0.0	1.3
Medication: Co-codamol	0.9	1.0	1.8	-0.4	-0.7	1.1	1.3	1.2
Medication: Metformin	0.5	0.7	2.9	1.7	0.8	0.2	0.4	0.0
Diabetes (father)	1.0	1.2	4.8	-2.2	0.0	-0.7	-0.1	-0.8
Diabetes (mother)	4.8	6.1	11.5	0.5	1.8	-2.7	-3.4	-2.9
Severe depression (siblings)	0.5	0.5	1.6	-0.4	-1.2	0.5	-0.6	0.5
Pack years adult smoking proportion	2.4	3.6	5.9	1.1	1.6	-2.4	-2.0	-2.1
Impedance of leg (right)	1.9	9.3	15.6	0.8	4.0	-3.2	2.9	-3.4
Leg fat-free mass (left)	1.1	6.1	11.9	0.8	-3.5	2.9	-1.2	2.9
Trunk fat percentage	0.4	1.6	4.3	1.3	0.2	-1.1	-2.1	-0.8
Hand grip strength (right)	0.8	2.1	3.3	1.8	-1.7	1.2	1.2	1.1
Townsend deprivation index at recruitment	0.4	0.5	1.9	-0.5	1.4	-0.2	-0.0	-0.7
Current tobacco smoking	0.9	1.5	3.0	0.9	1.3	-1.0	-1.7	-1.0
Average weekly fortified wine intake	0.3	0.4	1.1	-0.7	-1.0	0.3	0.3	0.1
Maternal smoking around birth	0.4	0.6	2.6	1.6	0.6	0.4	-0.1	0.2
Fed-up feelings	0.5	0.8	3.2	0.9	1.8	-0.2	0.4	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.4	0.1	0.2	-0.1	-1.8	0.8
Relative age voice broke	0.6	0.9	2.3	-1.5	-0.8	0.5	-1.0	0.6
Taking other prescription medications	0.6	0.9	1.5	0.9	1.2	-1.2	-0.3	-0.8
Age when periods started (menarche)	0.6	1.4	2.1	-1.1	-1.2	1.4	1.0	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.3	-0.2	0.3	-0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	8.4	-2.9	-1.4	-0.7	1.0	0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.9	0.2	1.4	-1.2	-0.2	-0.8
Qualifications: CSEs or equivalent	0.3	0.4	1.4	-1.2	0.0	-0.1	-0.1	-0.9
Serious illness, injury or assault to yourself	2.6	3.2	8.2	0.7	-2.2	0.2	-2.9	1.4
High blood pressure	0.5	1.4	3.4	0.6	1.4	-0.8	-1.8	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.1	-1.5	-1.8	1.2	0.9	0.4
Multivitamins +/- minerals	0.3	0.4	1.0	-0.1	0.0	1.0	0.6	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.8	0.4	1.4	-0.3	0.1	-0.6
Supplements: Glucosamine	0.8	1.1	2.5	0.0	-1.6	1.1	0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	-1.1	-0.4	-0.7	-0.6	-1.2
Medication: Atenolol	1.2	1.6	4.0	2.0	0.8	-1.3	-0.5	-1.2
Medication: Levothyroxine sodium	2.3	3.9	7.2	0.3	2.7	-2.3	0.6	-2.5
Sitting height	0.0	0.3	0.7	0.5	-0.8	-0.0	0.7	-0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	-1.4	0.5	-0.7	-0.7	-1.0
High blood pressure (mother)	0.1	0.1	0.4	-0.1	-0.2	0.2	-0.6	-0.1
Body mass index (BMI)	0.7	3.1	12.8	1.0	-1.2	0.2	-3.6	0.4
Impedance of leg (left)	1.8	8.6	13.3	0.6	3.6	-2.9	3.2	-3.2
Leg predicted mass (left)	1.1	5.9	11.4	0.7	-3.4	2.8	-1.2	2.9
Trunk fat mass	0.3	1.1	3.2	1.4	-0.6	-0.1	-1.8	0.0
Waist circumference	0.7	2.7	4.9	1.8	-1.5	1.2	-2.2	1.3
Number of incorrect matches in round	1.8	3.0	7.3	2.7	-0.8	1.3	1.7	1.6
Past tobacco smoking	1.0	1.8	3.3	-1.5	-1.8	-0.6	-1.7	-0.5
Alcohol usually taken with meals	0.7	1.2	3.2	0.8	-1.8	1.2	0.3	0.6
Nervous feelings	0.7	1.2	2.0	1.2	1.3	-0.9	-1.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	3.8	1.1	0.7	-0.0	-1.9	0.6
Hearing difficulty/problems with background noise	0.8	1.4	2.5	0.4	1.5	-1.6	-1.3	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.4	-0.1	-0.1	0.6	0.3
Had menopause	1.0	1.2	5.1	2.3	0.9	0.2	0.3	0.3
Had other major operations	0.6	0.7	1.2	1.0	-0.4	0.8	-0.7	1.1
Forced vital capacity (FVC)	1.1	4.3	20.9	-0.1	-0.1	0.4	4.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	7.9	-2.8	-0.7	-0.9	1.8	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.4	1.1	-0.3	0.2	-1.5	1.0
Qualifications: None of the above	1.8	3.9	10.2	0.6	3.2	-2.0	-1.4	-1.6
Financial difficulties in last 2 years	0.5	0.7	3.0	-0.6	0.2	-0.4	-1.7	0.0
Mouth/teeth dental problems	2.9	4.4	13.2	-3.6	1.0	-1.5	0.1	-2.4
Heart attack	1.0	1.3	2.9	1.6	0.1	-1.0	-1.7	0.4
Allergy	0.3	0.7	2.0	0.7	1.4	-0.9	-0.3	-0.2
Pain all over the body in last month	0.1	0.1	0.3	0.3	-0.3	0.4	0.5	0.4
Diabetes (self-reported)	0.9	1.4	3.2	0.6	1.8	-1.3	0.2	-1.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.7	0.1	0.3	-0.2	0.8	-0.2
Medication: Ramipril	0.5	0.7	3.0	0.1	0.3	-0.4	-1.7	-0.4
Medication: Simvastatin	0.4	0.6	2.8	0.0	1.7	-0.3	0.4	-0.0
Fluid intelligence score	0.2	0.3	0.8	0.2	-0.3	0.8	-0.3	0.9
Illnesses of siblings	0.2	0.3	0.7	0.5	0.6	-0.8	0.6	-0.3
Neuroticism score	0.7	1.4	2.5	1.6	1.5	-0.3	-1.4	0.3
Weight	0.8	3.8	7.4	1.0	-2.7	1.9	-1.8	2.0
Impedance of arm (right)	0.8	3.6	6.4	-1.0	2.1	-2.0	2.5	-1.5
Arm fat percentage (right)	0.6	2.5	9.1	0.7	0.6	-1.3	-3.0	-0.9
Trunk fat-free mass	1.2	6.7	12.5	0.6	-3.5	3.4	-0.4	3.0
Hip circumference	0.8	3.4	7.8	0.4	-2.6	1.1	-2.8	1.1
Time employed in main current job	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.4	0.3
Alcohol intake versus 10 years previously	0.8	1.2	2.0	0.4	-1.4	1.4	-0.7	1.1
Father’s age at death	0.4	0.5	0.9	-0.9	-0.7	0.4	-0.9	0.5
Worrier / anxious feelings	0.9	1.7	6.9	0.9	0.6	-0.5	-2.6	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	5.0	0.2	-0.1	-0.1	-2.2	0.1
Falls in the last year	0.3	0.4	0.9	0.9	-0.3	0.6	0.9	0.2
Hair/balding pattern: Pattern 3	1.8	2.6	4.4	-0.1	-1.7	2.1	1.3	2.0
Number of live births	0.6	0.8	3.3	-0.2	0.7	0.5	1.8	-0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	12.0	-0.1	-0.8	0.8	3.5	0.1
Pulse rate	1.2	2.0	4.0	-1.6	0.4	-1.2	2.0	-1.3
Happiness	0.3	0.3	0.9	1.0	-0.1	0.2	0.4	0.7
Noisy workplace	0.5	0.6	1.4	0.5	-0.3	1.0	0.4	1.2
Qualifications: A levels/AS levels or equivalent	1.4	3.2	10.2	-1.2	-3.2	1.4	-0.0	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	0.3	-1.4	0.7	-0.5	1.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.9	1.0	-0.5	0.2	-0.1
Asthma	1.4	2.7	5.9	0.6	1.3	-1.9	-1.4	-2.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.8	-0.3	-0.6	-0.1	-1.1
Medication: Cholesterol lowering	0.2	0.3	0.6	0.6	0.7	-0.5	0.2	0.3
Depression (self-reported)	2.6	3.1	6.6	2.6	1.4	-0.9	-2.4	-0.3
Medication: Lansoprazole	1.7	2.0	4.2	-1.0	2.0	-1.5	-0.6	-1.4
Prospective memory result	1.6	1.9	3.4	-1.8	-1.5	1.3	-0.8	1.3
Lung cancer (father)	1.1	1.3	2.7	1.6	-0.4	1.5	1.0	0.8
Illnesses of mother	0.1	0.1	0.5	0.5	-0.7	0.2	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	5.6	-0.4	-1.1	0.7	2.4	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	0.4	1.5	-0.2	-0.7	0.2
Impedance of arm (left)	0.9	4.1	6.9	-0.7	2.4	-2.6	1.8	-2.0
Arm fat mass (right)	0.4	1.8	6.9	1.2	-0.8	0.1	-2.6	0.2
Trunk predicted mass	1.2	6.6	12.6	0.6	-3.5	3.4	-0.4	2.9
Standing height	1.0	10.1	13.3	0.1	-3.5	3.6	3.6	3.4
Length of working week for main job	0.6	0.6	1.3	-0.7	-1.1	1.2	0.4	0.3
Exposure to tobacco smoke at home	0.4	0.5	1.0	-0.2	-1.0	1.0	0.0	0.7
Breastfed as a baby	1.3	1.6	4.3	-0.2	-2.1	1.2	-0.4	1.4
Tense / ‘highly strung’	0.9	1.4	3.3	1.8	-0.1	1.3	-0.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.9	-0.3	0.5	-0.4	0.9
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.3	0.3	0.1	0.3	-0.4
Birth weight of first child	6.2	11.3	20.3	-1.5	-4.5	4.0	1.7	3.8
Peak expiratory flow (PEF)	0.8	1.8	7.7	0.4	-0.6	0.9	2.8	0.0
Pulse wave reflection index	0.1	0.2	0.7	-0.1	0.8	0.1	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.9	0.2	0.6	-0.3	-1.4	0.7
Loud music exposure frequency	1.5	1.6	6.6	0.4	-0.8	0.7	2.6	0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.6	-2.6	-1.9	-0.2	-1.0	0.2
Mouth/teeth dental problems: Bleeding gums	4.2	5.5	8.1	1.6	-2.6	2.9	1.5	2.8
Blood clot in the leg (DVT)	0.3	0.5	0.8	0.3	-0.7	0.4	0.9	0.8
Medication: Paracetamol	0.4	0.7	1.9	-0.2	1.2	-0.3	1.4	-0.5
Headache pain in last month	0.3	0.6	0.9	-0.7	0.2	-0.8	-0.9	-0.9
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.4	-0.8	-2.1	1.8	-0.3	1.5
Glaucoma (self-reported)	0.8	1.0	1.6	0.5	0.2	-1.3	-1.3	-1.2
Gout (self-reported)	0.1	0.2	0.3	0.6	0.5	-0.4	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	4.5	1.3	2.1	-1.1	1.9	-1.4
Medication: Amlodipine	0.4	0.6	1.0	-1.0	0.1	-0.4	-1.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	0.9	-0.5	0.8	-1.0	0.6
Birth weight	0.9	1.9	3.3	-1.4	-1.1	1.8	0.1	1.7
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.3	-0.9	-1.1	1.1	0.6	1.1
High blood pressure (siblings)	0.3	0.4	0.9	-0.4	-0.9	0.5	-0.9	-0.2
Forced vital capacity (FVC), Best measure	0.8	3.0	14.1	-0.4	-0.5	0.6	3.8	-0.0
Body fat percentage	0.6	2.4	6.2	1.5	0.6	-1.4	-2.5	-1.1
Leg fat percentage (right)	0.9	3.1	5.2	1.8	1.4	-1.6	-2.3	-1.6
Arm fat-free mass (right)	1.0	5.0	10.3	1.2	-3.2	2.7	-1.0	2.2
Exposure to tobacco smoke outside home	0.3	0.5	1.1	-0.4	-0.3	1.1	0.7	0.6
Comparative body size at age 10	0.2	0.4	0.8	-0.8	-0.6	0.7	-0.2	0.9
Number of full brothers	0.6	0.8	2.7	-0.8	1.6	-0.2	0.6	0.2
Worry too long after embarrassment	0.3	0.5	1.0	1.0	0.3	0.3	-0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.7	1.7	-0.4	0.4	-1.9	0.9
Wheeze or whistling in the chest in last year	0.9	1.7	3.4	-0.6	0.7	-1.4	-1.8	-1.5
Number of children fathered	0.3	0.4	0.9	-0.1	-0.0	0.1	-1.0	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.3	-0.2
Age at first live birth	1.4	2.6	4.8	-2.2	-2.2	1.2	-1.0	0.8
Pulse wave peak to peak time	0.5	0.6	1.9	-0.2	-1.4	0.2	0.9	-0.1
Health satisfaction	0.4	0.5	1.3	0.9	0.4	0.1	1.2	0.3
Shortness of breath walking on level ground	0.1	0.2	0.7	0.2	0.2	-0.2	-0.8	0.1
Qualifications: College or University degree	2.1	6.7	12.9	1.8	-3.6	2.8	1.0	3.0
Eye problems/disorders: None of the above	1.1	1.2	3.3	-0.1	-1.0	1.3	0.3	1.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.8	0.3	-0.1	0.0	-1.3	-0.1
Emphysema/chronic bronchitis	2.1	2.4	6.4	0.6	2.5	-1.9	-0.2	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.4	1.0	-0.1	-1.0	0.9	0.3	0.6
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.6	-0.0	-0.4	-0.9	-0.8
Medication: Blood pressure	1.7	2.9	5.4	1.1	2.3	-2.1	-0.2	-2.0
Angina (self-reported)	0.6	0.8	1.9	0.2	-1.4	0.4	-0.5	1.2
Migraine (self-reported)	1.4	1.8	3.1	1.2	-1.5	1.3	-0.5	1.8
Medication: Ibuprofen	0.5	0.6	1.4	1.2	-0.8	-0.6	-0.0	-0.9
Medication: Allopurinol	0.2	0.3	0.6	-0.4	-0.3	0.7	0.4	0.8
Medication: Omeprazole	0.8	0.9	2.1	0.2	1.4	-0.6	0.7	-1.3
Medication: Seretide 50 evohaler	1.5	1.7	3.7	1.2	-1.2	0.9	1.9	1.1
Mean time to correctly identify matches	0.2	0.4	1.4	-0.2	-0.7	0.2	0.0	1.2
Heart disease (mother)	0.4	0.4	1.1	-0.2	1.1	-0.7	-0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.3	0.2	0.2	0.9	0.9
Whole body fat mass	0.3	1.4	4.5	1.5	-0.5	-0.2	-2.1	-0.1
Leg fat mass (right)	0.4	1.6	4.1	1.9	-0.1	-0.2	-2.0	-0.2
Arm predicted mass (right)	1.0	5.3	10.4	1.4	-3.2	2.8	-0.9	2.3
Pulse rate, automated reading	0.8	2.7	10.8	-0.2	0.8	-0.4	3.3	-1.4
Alcohol intake frequency.	1.0	2.2	3.7	1.4	-1.9	1.4	-1.2	1.5
Comparative height size at age 10	1.6	8.5	13.3	1.4	-2.6	3.0	3.4	3.6
Number of full sisters	0.3	0.4	1.0	0.7	0.1	-0.5	1.0	-0.3
Suffer from ‘nerves’	0.6	0.9	2.0	0.4	-0.0	1.1	1.4	1.1
Overall health rating	0.3	0.7	2.1	0.4	0.5	-1.0	-1.4	0.1
Chest pain or discomfort	0.6	0.9	2.7	-0.4	-1.6	0.8	0.7	0.6
Had major operations	0.8	1.0	2.5	1.6	-0.8	0.7	1.1	0.2
Age at last live birth	1.2	1.7	5.8	-2.4	-1.3	0.8	-0.2	0.5
Family relationship satisfaction	1.1	1.3	2.0	1.4	0.7	-1.2	-1.4	-0.8
Leg pain on walking	3.2	4.0	6.3	-1.7	-2.5	2.4	-0.9	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	-0.7	0.0	-0.7	-0.2	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	-0.7	-1.1	-0.2	-1.1	-0.0
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.3	0.2	2.3	-1.3	1.5	-2.0
Medication: Aspirin	0.7	0.9	2.0	0.0	1.4	-1.4	-0.2	-0.9
Supplements: Vitamin C	0.7	0.8	2.5	1.6	-0.7	0.6	-0.5	0.6
Knee pain experienced in last month	0.0	0.0	0.1	-0.3	-0.0	0.4	-0.0	-0.0
Hypertension (Self-reported)	0.5	1.3	3.1	0.5	1.4	-0.7	-1.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	0.7	1.3	-1.4	0.2	-0.6
Illnesses of father: Heart disease	0.3	0.4	1.1	0.9	0.4	0.2	-0.0	-1.0
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	0.4	-0.2	-0.0	0.3
Smoking status: Previous	1.1	1.7	3.8	1.2	0.8	1.2	1.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	5.6	0.6	-2.4	1.9	1.0	2.4
Whole body fat-free mass	1.2	6.8	13.4	0.8	-3.7	3.2	-0.8	3.0
Leg fat-free mass (right)	1.4	7.3	14.5	0.6	-3.8	3.2	-1.1	3.2
Arm fat percentage (left)	0.8	3.0	11.2	1.0	0.5	-1.4	-3.4	-1.0
Average weekly red wine intake	1.0	1.5	2.6	0.3	-1.6	1.5	0.1	1.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	5.9	-2.4	0.1	-0.4	-0.5	-0.4
Mood swings	0.8	1.4	5.0	2.2	1.3	-0.1	-0.3	0.2
Loneliness, isolation	1.1	1.5	6.2	-0.7	0.3	-0.8	-2.5	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.7	0.0	-0.1	-0.9	0.0
Ever had bowel cancer screening	0.7	0.8	1.9	-0.4	-1.0	0.7	-0.8	1.4
Diabetes diagnosed by doctor	0.9	1.4	3.1	1.1	1.8	-1.1	0.2	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.0	0.1	0.7	-0.5	0.4
Friendships satisfaction	0.7	0.8	3.1	0.5	-0.6	0.0	-1.8	0.5
Qualifications: nursing, teaching	2.1	3.2	10.4	-0.7	-3.2	1.6	-0.3	1.5
Commuting to job workplace: Walk	0.4	0.4	1.1	-1.0	-0.3	-0.2	0.9	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.5	-0.3	0.2	0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.6	1.9	-1.7	1.6	0.1	2.6
Medication for cholesterol	0.6	0.9	4.3	2.1	-0.3	-0.2	-0.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	6.0	0.4	1.4	-2.5	-2.2	-1.5
Back pain experienced in last month	0.2	0.3	0.6	0.7	-0.1	0.3	-0.3	0.8
Mineral and other dietary supplements	0.4	0.6	1.7	0.5	0.5	-0.7	-1.3	-0.3
Breast cancer (self-reported)	1.5	1.8	4.9	0.4	-1.3	1.5	-0.2	2.2
Asthma (self-reported)	1.2	2.4	5.2	0.8	1.1	-1.7	-1.4	-2.3
Osteoporosis (self-reported)	0.2	0.3	0.6	0.7	0.4	0.0	0.8	-0.1
Osteoarthritis (self-reported)	0.6	0.7	3.3	-0.2	0.3	0.4	1.8	0.4
Medication: Aspirin	0.7	0.9	1.9	0.4	1.2	-1.4	-0.5	-0.7
Medication: Gliclazide	0.2	0.2	0.5	0.7	-0.2	0.2	-0.7	0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	1.4	-0.5	0.3	-0.2	1.3
Smoking status: Current	1.1	1.8	2.6	1.2	1.6	-1.2	-1.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.9	-1.1	0.2	-0.4	2.0	-0.6
Whole body water mass	1.2	6.8	13.3	0.8	-3.6	3.2	-0.9	3.0
Leg predicted mass (right)	1.4	7.4	14.7	0.5	-3.8	3.3	-1.1	3.2
Arm fat mass (left)	0.5	2.0	7.8	1.3	-0.8	-0.1	-2.8	0.1
Number of self-reported non-cancer illnesses	1.0	1.7	4.4	-0.0	2.1	-1.5	-0.8	-1.2
Average weekly champagne plus white wine intake	0.6	0.8	2.0	0.7	0.0	-0.8	0.9	-1.4
Miserableness	0.4	0.7	1.4	0.3	1.2	-0.9	-0.9	-0.7
Guilty feelings	0.2	0.3	1.1	-1.1	0.3	-0.7	-0.1	0.1
Wears glasses or contact lenses	0.6	0.6	1.4	0.0	-0.5	1.1	1.2	0.6
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.6	1.3	-1.2	0.2	-0.9
Hearing aid user	0.9	1.0	2.7	1.6	1.2	-0.7	-0.2	-0.3
Mother’s age at death	1.2	1.6	5.5	-0.5	-2.3	0.7	-0.8	0.9
Financial situation satisfaction	1.1	1.4	3.5	0.3	1.9	-1.2	-1.3	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.4	0.7	0.2	1.0	0.1
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.7	0.6	-0.5	0.0	-0.7
Eye problems/disorders: Glaucoma	1.7	2.1	3.6	0.5	1.0	-1.9	-1.7	-1.7
Medication: Blood pressure	0.8	1.5	4.1	-1.8	-0.3	-0.4	-2.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.6	-0.9	0.9	0.4	1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	-1.1	0.4	-0.4	0.9	-0.9
High cholesterol (Self-reported)	1.1	1.9	5.8	0.2	2.4	-1.3	0.7	-1.2
Medication: Bendroflumethiazide	2.5	3.8	6.3	-0.7	1.9	-2.5	-1.7	-2.4
Medication: Paracetamol	0.4	0.6	1.8	-0.2	-0.1	0.6	1.3	0.7
Medication: Lisinopril	0.7	1.0	1.5	1.2	1.2	-1.0	-0.9	-0.1
Medication: Atorvastatin	0.3	0.4	0.9	0.1	0.2	-0.9	-0.9	-0.6
Illnesses of father: High blood pressure	0.9	1.1	2.2	0.8	1.5	-1.1	-0.3	-1.2
Alcohol drinker status: Never	1.0	1.2	4.2	0.6	-0.6	0.8	2.0	0.5
Ever smoked	0.7	1.3	3.1	1.3	1.8	0.4	1.3	0.2
Basal metabolic rate	1.1	6.0	11.8	1.0	-3.4	3.0	-1.0	2.7
Leg fat percentage (left)	0.7	2.4	4.4	1.6	1.1	-1.4	-2.1	-1.4
Arm fat-free mass (left)	1.0	4.9	10.0	0.9	-3.2	2.8	-0.8	2.2
Number of operations (self-reported)	0.2	0.3	0.8	0.9	0.2	0.7	0.0	0.5
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.1	-0.4	0.7	1.1	1.0
Irritability	1.8	3.1	6.2	2.5	2.5	-0.8	-1.6	-0.3
Risk taking	0.6	0.9	1.7	0.9	1.2	-0.6	0.5	-1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-1.3	-0.7	0.9	0.3	0.8
Fractured/broken bones in last 5 years	0.7	0.9	1.7	-0.4	1.3	-1.3	-0.9	-0.6
Age started oral contraceptive pill	0.6	0.8	2.1	-1.3	-0.2	0.1	-1.4	0.2
Diastolic blood pressure, automated reading	1.9	5.9	12.8	1.5	2.5	-2.7	-1.0	-3.6
Ever depressed for a whole week	2.0	2.5	5.2	2.0	-1.1	1.1	-1.1	2.3
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.4	-0.6	-0.3	-0.2	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.2	-0.0	0.1	0.7	0.7
Myopia	0.8	1.2	5.5	0.3	0.5	0.1	2.4	0.4
Vascular/heart problems diagnosed by doctor	0.5	1.2	4.1	-0.3	-1.1	0.8	2.0	0.5
Cholesterol lowering medication	1.0	1.5	5.3	-0.1	2.3	-0.9	-0.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	0.0	1.4	-1.0	-0.2	-1.2
Pain experienced in last month	0.3	0.5	0.9	-0.4	0.8	-1.0	0.3	-0.9
Supplements: Calcium	0.7	0.8	2.2	0.7	-0.7	0.7	-1.5	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.6	-1.0	0.6	-0.2	0.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.3	2.0	-0.2	-0.9	-2.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	-0.2	-1.0	0.5	1.0	0.8
Heart disease (siblings)	0.6	0.7	1.5	-0.7	-0.5	1.0	1.2	0.8
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	-0.2	0.4	0.0	0.2
Pack years of smoking	2.1	3.1	4.8	1.1	1.6	-2.2	-1.9	-1.8
Impedance of whole body	1.3	6.8	9.1	-0.4	3.0	-2.8	2.9	-2.8
Leg fat mass (left)	0.4	1.4	3.8	2.0	-0.3	-0.0	-1.8	-0.0
Arm predicted mass (left)	0.9	4.4	8.9	1.1	-3.0	2.6	-1.1	2.0