Best TWAS P=1.2e-13 · Best GWAS P=1.23e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CTC-228N24.3 | 0.24 | 0.15 | enet | 16 | 0.20 | 3.4e-16 | 6.8 | -6.6 | 3.8e-11 | -0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CTC-228N24.3 | 0.24 | 0.16 | enet | 19 | 0.16 | 1.8e-08 | 6.8 | -5.4 | 5.3e-08 | -0.80 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adrenal Gland | CTC-228N24.3 | 0.34 | 0.10 | lasso | 9 | 0.09 | 4.2e-04 | 6.7 | -7.2 | 7.1e-13 | -0.88 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Artery Aorta | CTC-228N24.3 | 0.20 | 0.04 | lasso | 8 | 0.07 | 7.4e-05 | 2.3 | -6.3 | 2.4e-10 | -0.91 | 0.14 | 0.82 | FALSE |
| 5 | GTEx | Artery Coronary | CTC-228N24.3 | 0.31 | 0.10 | lasso | 3 | 0.10 | 2.9e-04 | 6.3 | -6.3 | 3.1e-10 | -0.86 | 0.02 | 0.85 | FALSE |
| 6 | GTEx | Artery Tibial | CTC-228N24.3 | 0.20 | 0.16 | lasso | 7 | 0.14 | 3.0e-11 | 6.8 | -6.7 | 1.7e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Cerebellar Hemisphere | SLC12A2 | 0.45 | -0.01 | enet | 20 | 0.01 | 2.1e-01 | 5.8 | -6.8 | 1.4e-11 | -0.46 | 0.04 | 0.35 | TRUE |
| 8 | GTEx | Brain Cerebellum | CTC-228N24.3 | 0.31 | 0.04 | lasso | 5 | 0.12 | 2.9e-04 | 6.8 | -5.6 | 2.5e-08 | -0.84 | 0.01 | 0.96 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | CTC-228N24.3 | 0.24 | -0.01 | enet | 26 | 0.04 | 2.2e-02 | 3.2 | -6.8 | 8.3e-12 | -0.57 | 0.04 | 0.63 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CTC-228N24.3 | 0.24 | 0.16 | enet | 26 | 0.16 | 8.6e-12 | 6.8 | -5.7 | 1.0e-08 | -0.89 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Colon Sigmoid | CTC-228N24.3 | 0.20 | 0.22 | enet | 11 | 0.23 | 1.1e-08 | 6.3 | -6.5 | 8.6e-11 | -0.92 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Esophagus Mucosa | CTC-228N24.3 | 0.18 | 0.14 | enet | 11 | 0.14 | 9.8e-10 | 6.8 | -6.7 | 1.7e-11 | -0.93 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Esophagus Muscularis | CTC-228N24.3 | 0.24 | 0.08 | enet | 29 | 0.14 | 1.4e-08 | 6.3 | -6.6 | 4.7e-11 | -0.75 | 0.01 | 0.99 | FALSE |
| 14 | GTEx | Heart Atrial Appendage | CTC-228N24.3 | 0.22 | 0.07 | lasso | 5 | 0.07 | 4.1e-04 | 6.2 | -6.8 | 1.1e-11 | -0.87 | 0.01 | 0.98 | FALSE |
| 15 | GTEx | Heart Left Ventricle | CTC-228N24.3 | 0.24 | 0.15 | lasso | 7 | 0.19 | 1.9e-10 | 5.8 | -6.1 | 1.2e-09 | -0.84 | 0.01 | 0.99 | FALSE |
| 16 | GTEx | Lung | CTC-228N24.3 | 0.18 | 0.14 | enet | 16 | 0.14 | 3.2e-11 | 6.8 | -7.4 | 1.2e-13 | -0.95 | 0.00 | 1.00 | TRUE |
| 17 | GTEx | Muscle Skeletal | CTC-228N24.3 | 0.25 | 0.20 | lasso | 5 | 0.21 | 1.6e-20 | 6.8 | -6.8 | 8.2e-12 | -0.95 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Nerve Tibial | CTC-228N24.3 | 0.32 | 0.18 | lasso | 10 | 0.16 | 1.6e-11 | 6.3 | -6.1 | 8.8e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Pancreas | CTC-228N24.3 | 0.14 | 0.19 | lasso | 2 | 0.17 | 1.1e-07 | 6.8 | -6.8 | 1.3e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-228N24.3 | 0.29 | 0.21 | lasso | 7 | 0.22 | 1.7e-12 | 6.8 | -6.5 | 7.1e-11 | -0.97 | 0.01 | 0.99 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | CTC-228N24.3 | 0.29 | 0.17 | enet | 12 | 0.22 | 4.3e-18 | 6.2 | -6.4 | 1.5e-10 | -0.90 | 0.01 | 0.99 | FALSE |
| 22 | GTEx | Spleen | CTC-228N24.3 | 0.26 | 0.03 | enet | 15 | 0.05 | 1.8e-02 | 2.3 | -6.0 | 2.1e-09 | -0.66 | 0.03 | 0.58 | FALSE |
| 23 | GTEx | Stomach | CTC-228N24.3 | 0.17 | 0.04 | lasso | 6 | 0.08 | 1.5e-04 | 5.8 | -6.8 | 8.8e-12 | -0.81 | 0.03 | 0.93 | FALSE |
| 24 | GTEx | Testis | CTC-228N24.3 | 0.30 | 0.16 | lasso | 6 | 0.14 | 1.1e-06 | 6.8 | -5.1 | 2.8e-07 | -0.93 | 0.00 | 1.00 | TRUE |
| 25 | GTEx | Thyroid | CTC-228N24.3 | 0.31 | 0.15 | enet | 32 | 0.18 | 4.6e-14 | 6.8 | -6.7 | 2.9e-11 | -0.78 | 0.00 | 1.00 | FALSE |
| 26 | METSIM | Adipose | CTC-228N24.3 | 0.17 | 0.19 | lasso | 6 | 0.18 | 1.9e-26 | 6.8 | -6.7 | 2.1e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | CTC-228N24.3 | 0.15 | 0.09 | lasso | 3 | 0.12 | 8.0e-15 | 6.8 | -6.5 | 6.2e-11 | -0.88 | 0.00 | 1.00 | TRUE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FBN2 | 0.02 | 0.03 | lasso | 4 | 0.02 | 1.0e-05 | -5.4 | -5.2 | 1.8e-07 | -0.18 | 0.71 | 0.28 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ33630 | 0.05 | 0.04 | enet | 14 | 0.03 | 2.1e-07 | 6.8 | -7.0 | 3.0e-12 | -0.88 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Glioblastoma Multiforme | FLJ33630 | 0.38 | 0.20 | lasso | 5 | 0.17 | 6.5e-06 | 6.8 | -6.7 | 2.4e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ33630 | 0.10 | 0.07 | lasso | 3 | 0.08 | 7.0e-09 | 6.3 | -6.6 | 4.2e-11 | -0.95 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ33630 | 0.10 | 0.06 | enet | 18 | 0.08 | 2.0e-09 | 6.8 | -6.2 | 5.9e-10 | -0.79 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FBN2 | 0.12 | 0.02 | enet | 17 | 0.05 | 1.7e-06 | 6.1 | -6.6 | 5.3e-11 | -0.53 | 0.02 | 0.95 | FALSE |
| 34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ33630 | 0.19 | 0.16 | enet | 4 | 0.16 | 1.2e-17 | 6.8 | -6.7 | 2.3e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ33630 | 0.07 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | 6.3 | -6.3 | 2.8e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ33630 | 0.09 | 0.08 | lasso | 4 | 0.09 | 4.9e-10 | 6.8 | -6.7 | 2.3e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ33630 | 0.08 | 0.03 | lasso | 2 | 0.04 | 5.7e-03 | 6.3 | -6.9 | 4.4e-12 | -0.90 | 0.01 | 0.88 | FALSE |
| 38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ33630 | 0.08 | 0.05 | blup | 70 | 0.04 | 4.4e-05 | 6.3 | -6.0 | 2.4e-09 | -0.86 | 0.00 | 1.00 | FALSE |
| 39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC12A2 | 0.04 | 0.02 | enet | 17 | 0.02 | 3.3e-03 | 6.3 | 5.4 | 8.6e-08 | 0.69 | 0.01 | 0.82 | FALSE |
| 40 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FBN2 | 0.09 | 0.04 | blup | 159 | 0.06 | 4.6e-05 | -4.7 | -5.5 | 4.2e-08 | -0.25 | 0.69 | 0.03 | FALSE |
| 41 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FLJ33630 | 0.07 | 0.02 | blup | 70 | 0.02 | 1.5e-02 | 4.6 | -5.3 | 8.9e-08 | -0.48 | 0.12 | 0.14 | FALSE |
| 42 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ33630 | 0.26 | 0.14 | lasso | 3 | 0.13 | 2.2e-05 | 6.8 | -6.7 | 1.9e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 43 | The Cancer Genome Atlas | Thyroid Carcinoma | FLJ33630 | 0.10 | 0.10 | lasso | 2 | 0.09 | 5.3e-09 | 6.8 | -6.8 | 1.4e-11 | -1.00 | 0.00 | 1.00 | FALSE |