Best TWAS P=7.8e-11 · Best GWAS P=6.17e-11 conditioned to 0.000485
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SENP6 | 0.08 | 0.00 | enet | 5 | 0.00 | 8.2e-01 | -5.6 | -6.5 | 7.8e-11 | 0.76 | 0.03 | 0.60 | TRUE |
| 2 | GTEx | Nerve Tibial | SENP6 | 0.11 | 0.09 | enet | 17 | 0.08 | 3.1e-06 | 6.3 | -5.5 | 4.6e-08 | 0.06 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | MYO6 | 0.11 | 0.03 | lasso | 3 | 0.04 | 2.1e-03 | -5.6 | 5.8 | 5.1e-09 | -0.70 | 0.08 | 0.72 | FALSE |
| 4 | YFS | Blood | SENP6 | 0.09 | 0.08 | blup | 357 | 0.09 | 5.2e-27 | 6.3 | -5.1 | 2.6e-07 | 0.07 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO6 | 0.04 | 0.03 | blup | 105 | 0.05 | 7.0e-06 | 4.6 | 5.3 | 1.1e-07 | -0.23 | 0.08 | 0.86 | FALSE |