Hub : Genes

SENP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0280	5.7e-04	0.018	0.021	0.025	0.023	0.016	2.4e-03	1.2e-03	4.1e-04	7.1e-04	3.7e-03
2	GTEx	Artery Tibial	0.0758	0.0308	2.7e-03	-0.003	NA	-0.003	NA	-0.003	6.7e-01	NA	8.2e-01	NA	9.1e-01
3	GTEx	Cells Transformed fibroblasts	0.0870	0.0320	2.3e-04	0.042	NA	0.068	NA	0.032	4.3e-04	NA	8.8e-06	NA	1.9e-03
4	GTEx	Nerve Tibial	0.1108	0.0364	5.8e-06	0.094	NA	0.079	NA	0.046	3.7e-07	NA	3.1e-06	NA	3.1e-04
5	GTEx	Skin Not Sun Exposed Suprapubic	0.0720	0.0350	8.2e-03	0.091	NA	0.047	NA	0.062	1.0e-05	NA	1.3e-03	NA	2.6e-04
6	GTEx	Spleen	0.2140	0.0880	7.0e-03	0.110	NA	-0.006	NA	0.060	9.2e-04	NA	4.8e-01	NA	1.2e-02
7	GTEx	Whole Blood	0.0610	0.0230	1.5e-04	0.055	NA	0.053	NA	0.058	7.9e-06	NA	1.2e-05	NA	4.3e-06
8	METSIM	Adipose	0.0221	0.0112	6.0e-03	0.013	0.011	0.016	0.011	0.015	4.1e-03	8.2e-03	1.6e-03	6.8e-03	1.8e-03
9	NTR	Blood	0.0159	0.0065	2.2e-04	0.012	0.011	0.010	0.010	0.012	7.5e-05	1.5e-04	2.4e-04	2.2e-04	6.5e-05
10	ROSMAP	Brain Pre-frontal Cortex	0.1695	0.0391	0.0e+00	0.143	0.170	0.156	0.167	0.166	6.8e-18	2.5e-21	1.4e-19	6.0e-21	7.6e-21
11	YFS	Blood	0.0871	0.0219	0.0e+00	0.080	0.087	0.081	0.077	0.085	7.5e-25	5.2e-27	3.1e-25	6.6e-24	2.6e-26

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	3.4	1.8	0.7	-0.5	0.6	1.7	0.0	-1.0	0.8	-1.5	-1.6	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	1.2	1.1	-0.4	-0.1	-0.0	1.0	0.2	-0.5	0.3	-0.6	-0.4	0.1
Depressed Affect (Nagel 2018)	0.9	1.9	4.1	-0.4	-2.0	1.1	1.2	1.4	2.0	1.0	0.7	1.4	1.8	1.0
Depression (Nagel 2018)	0.4	0.6	1.7	-0.2	0.7	1.3	0.1	-0.7	0.4	0.8	1.1	0.7	0.4	0.8
Intelligence (Savage-Jansen 2018)	3.4	10.5	20.1	2.2	1.9	-2.5	-3.0	-1.2	-4.4	-3.7	-3.6	-4.0	-4.5	-2.9
Neuroticism (Nagel 2018)	0.6	1.5	6.2	0.3	-2.5	0.4	0.7	1.8	1.5	0.4	0.6	0.9	1.4	1.0
Schizophrenia (2018)	0.1	0.2	1.2	-0.2	-1.1	0.2	-0.5	-0.1	0.3	0.1	-0.3	0.5	0.7	-0.5
Schizophrenia vs Biploar Disorder	0.8	1.0	3.1	-0.7	-0.8	-0.6	-1.5	-1.0	-1.2	-0.5	-1.8	-0.1	0.1	-1.3
Worry (Nagel 2018)	1.2	2.5	8.4	2.0	-2.7	-0.5	1.1	2.9	1.4	-0.5	1.3	-0.0	0.8	1.4
Alzheimer’s Disease (in mother)	2.3	2.7	5.4	-1.0	0.1	1.6	1.9	0.0	1.8	2.1	1.8	2.3	1.9	1.7
Alzheimer’s Disease (in father)	1.4	1.5	4.8	1.8	-1.5	-1.5	-0.2	2.2	0.2	-1.3	0.9	-1.3	-0.2	0.3
Alzheimer’s Disease (including proxy)	1.6	2.4	6.2	-0.1	-0.4	1.1	1.8	1.0	1.6	1.5	2.5	1.7	1.6	2.1
Crohns Disease (2017)	0.4	0.8	2.5	0.5	-0.1	0.4	0.6	1.3	1.3	0.5	1.2	0.5	0.4	1.6
Irritable Bowel Disease (IBD)	0.7	1.6	3.4	0.2	-1.0	-1.4	-1.7	0.4	-1.3	-1.6	-1.8	-1.6	-0.7	-1.2
Ulcerative Colitis (UC)	3.1	5.8	15.0	-0.5	-1.6	-2.2	-3.0	-0.7	-2.8	-2.6	-3.9	-2.5	-0.9	-3.2
Major Depression (MDD)	0.7	0.9	3.1	-0.8	-1.7	-0.7	-0.6	-0.5	-0.7	-0.6	-0.8	0.1	0.5	-1.8
Reaction Time	0.6	1.2	4.1	-1.6	0.8	2.0	1.2	-0.0	0.7	1.2	0.8	1.2	0.3	0.8
Verbal and Numeric Reasoning (VNR)	2.2	5.4	10.2	1.5	0.4	-2.5	-2.0	-0.5	-2.8	-2.9	-2.5	-3.2	-2.8	-2.5
Breast Cancer	0.7	1.6	5.1	-0.5	-1.1	1.2	0.5	-0.7	1.7	1.6	-0.7	1.5	2.3	0.7
Ovarian Cancer	1.5	2.0	4.0	2.0	-1.4	-1.7	-1.2	0.9	-0.8	-1.8	-1.3	-1.5	-1.5	-0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	1.6	0.2	0.6	0.5	0.8	-0.0	0.1	0.4	1.3	0.3	0.3	0.9
Bipolar Disorder (2011)	0.6	0.5	2.8	-1.7	0.6	0.5	-0.8	-0.7	-0.8	-0.0	-0.7	0.0	-0.2	-0.5
Body Mass Index (BMI) (2010)	0.7	1.0	2.7	0.4	-1.6	0.3	0.5	1.0	1.5	0.4	1.0	0.3	1.6	0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.6	-1.2	0.7	1.2	-0.4	-1.6	-0.3	0.7	-0.7	0.6	0.4	0.0
Crohns Disease (2012)	0.8	1.3	3.4	0.0	-0.5	0.5	0.6	0.9	1.8	1.1	1.5	1.1	1.3	1.8
Mean Putamen Volume	0.1	0.1	0.3	-0.4	-0.4	0.3	-0.3	-0.0	0.2	0.1	-0.5	0.2	0.2	-0.0
Fasting Glucose	0.8	0.9	2.4	1.6	1.5	1.6	1.1	0.7	0.1	0.2	0.6	-0.4	-0.7	0.6
HbA1C	0.4	0.5	3.0	0.0	0.2	0.1	0.1	1.7	0.5	-0.2	-0.1	-0.5	-0.5	1.2
HDL Cholesterol	0.3	0.5	1.0	0.0	0.8	1.0	0.8	-0.9	0.5	0.9	-0.2	0.9	0.5	0.7
LDL Cholesterol	0.6	0.9	3.5	0.3	-1.9	-1.1	0.1	0.8	-0.4	-1.2	-0.8	-0.9	-0.3	-1.3
Lupus	1.1	1.6	4.5	0.3	-1.4	-1.1	-2.1	-0.5	-1.1	-1.2	-1.2	-0.8	-0.5	-2.1
Neuroticism (2016)	0.1	0.2	0.7	-0.4	-0.9	0.3	-0.7	-0.1	-0.1	0.2	-0.2	0.6	-0.3	0.1
Primary Biliary Cirrhosis	0.3	0.5	1.8	-0.5	-1.3	-0.5	0.2	-0.7	0.1	-0.0	-0.4	0.4	1.3	-0.6
Rheumatoid Arthritis	0.2	0.3	1.1	0.7	0.6	0.2	-0.4	0.2	-0.2	-0.3	0.5	0.2	-0.4	1.1
Schizophrenia (2014)	0.1	0.2	1.2	0.2	-1.1	0.0	-0.2	0.7	0.6	0.1	0.1	0.2	0.5	0.1
Triglycerides	0.3	0.5	1.2	-1.1	0.3	0.6	-0.8	-0.9	-0.8	0.1	-0.5	0.2	-1.0	-0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.2	-1.5	1.1	1.4	0.9	-0.5	0.2	1.1	0.7	0.8	-0.0	0.0
Ulcerative Colitis	4.0	5.8	12.7	-0.7	-2.2	-2.7	-3.0	-1.4	-2.8	-2.4	-3.6	-2.1	-0.6	-3.1
Blood Eosinophil Count	0.2	1.9	4.9	-1.5	0.3	2.2	0.1	-1.7	0.4	1.7	1.0	1.9	1.6	0.8
Blood Platelet Count	0.3	3.8	8.5	-0.8	-1.4	-1.2	-2.9	-1.9	-2.5	-1.5	-2.8	-1.1	-0.3	-2.9
Blood Red Count	0.2	2.0	9.4	0.5	3.1	1.3	-0.1	-2.6	-1.2	0.7	0.1	0.7	-1.2	0.2
Blood White Count	0.5	3.5	16.5	-2.7	0.3	0.5	-1.7	-4.1	-1.6	1.0	-1.2	1.6	0.9	-1.8
Heel T-Score	0.1	1.2	4.4	-0.9	2.1	0.7	0.2	-1.9	-0.6	0.8	-1.1	0.6	-0.7	0.6
BMI	1.6	9.4	19.7	-3.0	-1.0	3.4	1.9	-0.5	3.5	4.0	2.2	4.4	3.8	3.2
Height	3.1	60.0	216.1	4.4	14.5	-2.2	-2.3	-3.1	-9.6	-5.5	-1.2	-7.8	-14.7	-3.1
Waist Hip Ratio (WHR)	1.1	4.8	12.4	-3.3	2.2	2.2	0.6	-3.5	0.2	3.0	0.6	2.8	1.1	0.6
Systolic Blood Pressure	1.3	6.8	12.9	-1.5	-0.0	1.5	2.5	-0.5	2.9	3.2	3.3	3.4	3.6	3.1
Smoking Status	0.8	2.0	10.0	0.8	-3.2	-1.1	-0.9	2.0	0.7	-1.3	-0.0	-1.1	1.1	-0.8
Allergy or Eczema	0.4	1.1	4.7	2.2	-0.2	0.3	-0.7	1.7	0.5	-0.5	0.9	-0.9	-0.4	1.2
Cardiovascular Disease	0.6	2.0	4.5	-1.1	1.0	1.4	0.6	-0.7	1.2	2.1	2.0	1.9	0.5	1.7
Hypothyroidism (self reported)	0.2	0.3	1.0	0.7	-0.9	-1.0	-0.0	0.2	-0.5	-0.8	-0.2	-0.7	0.0	-0.3
Respiratory disease	0.7	1.6	3.6	-0.0	0.8	1.9	1.3	1.7	1.6	1.2	1.7	0.9	0.5	1.2
Type 2 Diabetes (T2D) (2018)	2.7	5.1	9.5	-2.6	2.4	3.0	1.6	-3.0	0.9	3.1	1.3	2.9	1.2	0.7
Lung FEV1/FVC ratio	0.5	2.5	15.1	-1.0	-3.9	-0.8	0.4	1.4	1.5	0.1	-0.5	0.7	2.4	0.3
Lung FVC	3.2	16.2	42.3	-0.4	-6.5	-4.3	-5.5	-0.0	-2.9	-4.1	-4.8	-3.3	0.4	-5.1
Neuroticism	0.8	1.8	3.0	-0.2	-1.2	1.5	1.6	1.5	1.7	1.1	1.5	1.4	1.1	1.5
Chronotype (morning person)	0.5	1.2	3.0	-0.8	-1.5	-1.7	1.4	1.6	1.0	-0.0	0.6	-0.0	1.0	-0.2
Hair Pigment	0.1	3.4	6.6	-2.0	2.6	2.4	2.2	-1.5	-0.6	2.5	1.6	1.7	0.4	1.5
Tanning	0.1	0.8	2.8	0.6	-1.2	-1.7	1.2	1.0	0.2	-1.0	0.5	-0.7	0.6	-0.3
Hand grip strength (left)	2.2	5.9	11.6	1.0	-1.2	-2.4	-2.4	-0.9	-3.4	-2.9	-3.2	-2.8	-2.3	-2.5
Number of treatments/medications taken	0.8	1.4	2.7	-1.4	1.1	1.5	0.5	-1.3	0.7	1.6	1.1	1.6	0.5	0.8
Average weekly spirits intake	0.9	1.1	2.9	0.1	1.7	0.6	-1.1	-1.1	-1.6	-0.5	-0.1	-0.7	-1.6	-0.6
Sensitivity / hurt feelings	0.8	1.4	4.1	-1.9	-0.3	1.1	0.5	-0.0	0.9	1.4	0.6	1.6	2.0	0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.7	0.3	1.2	-0.2	-1.1	0.2	1.0	0.5	1.0	0.6	0.0
Hearing difficulty/problems: Yes	2.9	4.4	11.1	-0.4	-1.9	1.7	1.6	0.8	3.3	2.0	1.0	2.6	3.3	2.2
Relative age of first facial hair	3.7	7.6	17.2	0.7	-2.3	-2.9	-4.2	0.7	-3.0	-3.2	-3.2	-3.2	-2.4	-2.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	1.4	0.8	-0.8	-0.3	0.1	-1.0	-0.9	-0.3	-0.8	-0.7	-1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.0	1.4	-0.7	-0.5	-0.2	1.0	0.5	-0.6	1.2	-0.5	-0.1	0.9
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	-1.0	0.2	0.7	-0.3	-0.3	0.2	0.5	0.4	0.2	0.3	0.7
Systolic blood pressure, automated reading	1.1	3.1	7.8	-0.2	-1.5	1.1	0.5	0.4	2.2	1.7	1.6	2.3	2.8	2.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.3	1.1	0.2	-0.4	0.9	0.7	0.7	-0.3	0.6	-0.6	0.1	-0.1
Angina	1.0	1.4	2.6	-1.2	0.7	1.5	1.6	-0.9	0.9	1.5	1.1	1.2	1.3	0.4
Medication for hormone replacement therapy	2.2	2.4	7.6	1.9	-2.7	-0.2	0.2	2.7	1.4	-0.6	0.8	-0.6	1.8	1.2
Vitamin and mineral supplements	0.4	0.5	1.6	-0.3	-0.1	0.4	0.1	0.4	0.9	0.8	0.4	1.3	1.1	0.9
Supplements: Zinc	1.1	1.2	4.0	0.5	1.8	0.7	1.1	-0.0	0.9	0.9	1.5	0.4	-0.2	2.0
Medication: Co-codamol	0.9	1.0	3.8	0.8	1.3	-0.0	0.0	-0.7	-1.2	-0.7	-0.1	-1.2	-1.9	-1.1
Medication: Metformin	7.1	10.0	20.1	-2.8	2.5	4.5	2.8	-2.3	2.8	4.3	2.2	4.0	2.9	2.6
Diabetes (father)	0.7	0.9	2.3	-0.2	-0.7	1.1	1.0	0.6	1.2	1.0	0.5	1.1	1.5	0.6
Diabetes (mother)	0.3	0.4	2.5	1.6	0.3	0.2	-0.0	0.4	-0.2	-0.5	-0.5	-0.8	-0.5	-0.2
Severe depression (siblings)	1.6	1.8	5.0	-1.7	-0.6	-1.5	-1.2	-1.0	-1.6	-0.7	-2.2	-0.6	-0.1	-1.9
Pack years adult smoking proportion	0.3	0.5	3.2	-0.2	-0.7	-0.1	0.4	-0.4	0.2	0.2	-0.6	0.4	1.8	-0.7
Impedance of leg (right)	0.4	1.8	9.4	1.1	3.1	0.1	-0.3	-1.8	-1.5	-0.0	0.6	-0.1	-1.8	0.2
Leg fat-free mass (left)	0.6	3.2	17.7	-1.2	4.2	2.0	1.2	-1.4	-1.1	0.8	0.3	0.1	-2.5	0.8
Trunk fat percentage	1.4	5.6	11.8	-0.5	1.7	3.4	2.0	-0.1	2.5	2.9	2.8	2.7	1.5	3.1
Hand grip strength (right)	2.2	5.9	9.7	0.9	-1.9	-3.1	-2.4	-0.8	-2.9	-2.8	-3.1	-2.9	-2.0	-2.4
Townsend deprivation index at recruitment	0.6	0.8	3.1	-0.8	-1.4	0.6	0.1	-0.6	0.5	0.6	-0.2	1.0	1.8	-0.6
Current tobacco smoking	0.3	0.6	1.4	-0.9	-1.2	0.6	0.1	-0.1	0.8	0.6	0.2	0.9	1.2	-0.4
Average weekly fortified wine intake	0.3	0.4	1.1	0.3	-0.3	-0.1	-1.0	0.4	-0.5	-0.6	-0.7	-0.4	-0.9	-0.6
Maternal smoking around birth	0.9	1.3	3.3	0.6	-1.8	0.0	0.9	1.6	1.8	0.3	1.0	0.3	1.1	1.2
Fed-up feelings	1.9	3.4	7.6	-0.6	-1.4	2.3	1.9	1.3	2.8	1.9	1.6	1.8	2.1	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	7.5	-1.8	1.7	2.7	1.0	-0.9	1.3	2.4	2.0	2.3	1.0	2.0
Relative age voice broke	6.4	9.8	19.3	1.7	-2.3	-3.3	-4.4	0.3	-3.5	-3.8	-3.3	-3.8	-2.4	-3.3
Taking other prescription medications	0.4	0.6	2.1	0.3	0.8	1.5	0.8	-0.4	0.6	0.6	1.4	0.6	0.0	0.6
Age when periods started (menarche)	5.3	12.8	27.5	5.2	-1.5	-4.2	-2.1	2.7	-2.9	-5.1	-1.5	-5.2	-3.1	-2.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.1	-1.3	-0.3	0.1	-0.4	-2.0	-0.5	0.5	-0.3	0.9	1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.8	-0.1	0.7	-1.2	-1.1	-0.8	-2.4	-1.5	-2.3	-1.5	-1.9	-1.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	0.9	0.1	1.3	1.0	0.8	0.9	0.4	0.1	0.5	0.1	1.2
Qualifications: CSEs or equivalent	1.1	1.4	5.3	-1.9	-1.0	0.5	0.2	-1.3	0.6	1.1	-0.2	1.4	2.3	-0.3
Serious illness, injury or assault to yourself	0.4	0.5	1.3	1.1	1.0	-0.3	0.1	0.3	-0.5	-0.6	0.3	-0.9	-0.9	0.5
High blood pressure	0.5	1.3	3.4	0.5	1.2	1.2	0.8	0.4	1.4	1.2	1.6	1.0	-0.1	1.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	6.0	2.4	-0.5	0.4	0.4	2.0	1.1	-0.2	2.1	-0.6	0.4	1.8
Multivitamins +/- minerals	2.3	2.9	6.7	0.0	0.6	-1.5	-0.8	-0.8	-2.4	-1.7	-1.6	-2.2	-2.4	-2.6
Stomach or abdominal pain in last month	0.9	1.1	2.9	0.0	1.6	1.7	1.0	-0.7	0.9	1.3	0.7	1.2	-0.0	-0.1
Supplements: Glucosamine	1.4	1.9	3.5	-0.3	0.9	-1.1	-1.5	-0.1	-1.9	-1.5	-1.0	-1.8	-1.8	-1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.4	1.0	-0.3	-0.6	0.0	-0.6	-0.4	0.5	-0.2	-0.6	0.4
Medication: Atenolol	1.2	1.6	2.8	-0.5	1.7	0.9	1.6	-0.8	1.0	1.5	1.6	1.4	0.2	1.4
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.0	0.8	0.2	-0.3	-0.5	-0.5	-0.1	-0.0	-0.2	-0.6	-0.5
Sitting height	1.9	13.6	48.0	2.2	5.7	-1.4	-1.4	-1.6	-5.0	-3.3	-1.4	-4.1	-6.9	-2.2
Chronic bronchitis/emphysema (father)	1.9	2.2	8.0	-1.9	0.3	0.7	-1.3	-2.8	-1.6	0.3	-1.8	0.5	-0.1	-2.1
High blood pressure (mother)	0.4	0.6	2.1	0.6	-1.3	0.3	-0.2	0.1	1.0	0.3	-0.1	0.4	1.4	1.0
Body mass index (BMI)	2.3	9.8	18.3	-2.8	0.6	4.2	2.7	-0.8	3.4	4.3	2.2	4.2	3.0	3.4
Impedance of leg (left)	0.3	1.4	6.2	1.6	2.5	-0.1	-0.2	-1.3	-1.4	-0.3	0.6	-0.5	-1.7	0.1
Leg predicted mass (left)	0.6	3.3	17.8	-1.2	4.2	2.1	1.3	-1.4	-1.0	0.9	0.3	0.1	-2.4	0.9
Trunk fat mass	1.2	5.2	12.5	-0.7	3.0	3.5	2.2	-0.6	1.7	2.7	2.4	2.3	0.1	2.9
Waist circumference	2.9	10.6	23.9	-2.8	3.8	4.9	3.0	-1.7	2.2	4.3	2.9	3.8	0.8	3.4
Number of incorrect matches in round	1.8	2.9	6.4	0.6	0.6	1.4	1.7	0.4	2.5	2.0	2.2	1.7	1.5	2.4
Past tobacco smoking	1.2	2.2	4.9	-2.2	2.0	1.3	1.1	-2.0	-0.1	1.9	-0.3	2.2	-0.3	0.5
Alcohol usually taken with meals	0.4	0.6	2.3	1.5	-0.0	-0.2	-0.0	1.5	0.2	-0.6	0.0	-0.7	-0.6	0.9
Nervous feelings	0.4	0.8	1.7	0.7	-1.3	-0.1	1.1	0.5	1.0	0.5	1.1	0.8	1.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.9	-0.8	-0.9	-0.9	0.7	-0.5	-0.9	0.3	-0.9	-0.4	-0.2
Hearing difficulty/problems with background noise	0.4	0.7	2.0	-0.1	-1.3	0.3	-0.1	0.5	1.4	0.5	0.2	0.8	1.4	0.9
Hair/balding pattern: Pattern 2	3.4	4.3	7.1	-2.2	0.5	2.6	2.7	0.6	2.0	2.5	1.9	2.3	1.9	2.3
Had menopause	2.5	3.1	8.0	2.8	-0.2	-1.2	-1.8	1.9	-0.8	-2.4	-0.0	-2.6	-2.1	-0.2
Had other major operations	0.4	0.5	2.0	-0.2	-1.3	-0.3	-0.5	0.8	0.5	-0.2	-0.3	-0.1	1.4	0.3
Forced vital capacity (FVC)	3.7	14.2	28.7	0.4	0.5	-2.6	-4.5	-1.9	-5.4	-4.0	-4.4	-4.3	-4.6	-4.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.3	-1.2	2.3	0.2	-0.7	-2.3	-2.5	-0.5	-2.1	-0.6	-2.4	-1.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.7	-0.8	1.1	1.5	1.2	-1.7	-0.3	1.2	1.2	1.5	0.5	-0.5
Qualifications: None of the above	1.5	3.1	6.9	0.4	-0.4	1.4	1.3	0.9	2.5	1.6	2.6	1.7	2.4	2.3
Financial difficulties in last 2 years	1.5	2.0	5.1	-0.2	0.4	-0.3	-0.9	-1.9	-2.0	-0.7	-2.3	-0.6	-1.8	-1.9
Mouth/teeth dental problems	1.8	2.8	11.7	-1.6	-2.2	0.5	0.8	-1.1	1.7	1.5	0.0	2.2	3.4	-0.3
Heart attack	2.5	3.2	6.3	-1.0	1.2	2.0	2.5	-0.1	2.1	2.1	2.3	1.9	1.3	1.8
Allergy	0.8	1.9	5.8	-0.9	-0.7	-1.9	-1.3	-1.1	-1.4	-1.2	-2.4	-0.7	-0.6	-1.8
Pain all over the body in last month	1.9	2.0	6.7	1.5	-0.4	-0.8	-2.6	-0.6	-1.5	-1.5	-0.9	-1.7	-1.3	-1.4
Diabetes (self-reported)	3.0	4.6	9.3	-1.8	2.0	2.7	2.2	-1.9	1.7	3.0	1.6	2.7	1.6	1.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.2	1.2	-1.0	0.4	-0.1	1.5	0.8	-0.6	0.5	-0.6	-0.5	0.7
Medication: Ramipril	1.5	1.9	5.2	-2.0	2.3	1.5	0.4	-1.7	0.1	1.8	0.4	1.6	-0.4	0.8
Medication: Simvastatin	0.7	1.0	2.1	0.0	0.8	1.4	0.8	-0.6	0.9	1.3	0.6	1.5	0.7	1.4
Fluid intelligence score	3.0	6.3	11.8	1.1	1.4	-2.2	-1.7	-0.9	-3.3	-2.8	-2.9	-3.2	-3.4	-3.0
Illnesses of siblings	1.3	1.9	4.6	-0.3	-2.1	-1.6	-1.3	0.7	-0.8	-1.6	-2.1	-1.1	-0.4	-1.5
Neuroticism score	0.7	1.5	3.1	-0.5	-1.6	1.2	1.0	0.6	1.3	1.1	1.3	1.5	1.8	0.8
Weight	1.2	5.8	25.3	-1.5	5.0	3.3	2.1	-1.8	0.1	2.3	1.5	1.5	-1.8	2.2
Impedance of arm (right)	0.7	3.3	7.3	2.3	-0.4	-2.3	-1.6	1.1	-1.7	-2.7	-0.3	-2.7	-1.5	-1.6
Arm fat percentage (right)	1.7	6.6	12.2	-1.9	0.1	3.5	2.0	-0.0	3.1	3.4	2.3	3.5	2.5	2.8
Trunk fat-free mass	1.3	7.5	42.4	-0.9	6.5	1.9	1.3	-2.2	-2.3	0.4	0.1	-0.6	-4.7	0.5
Hip circumference	2.3	10.0	27.4	-1.9	5.2	4.6	3.0	-1.1	1.6	3.5	3.0	2.9	-0.9	3.6
Time employed in main current job	0.4	0.5	2.4	-0.3	-0.8	0.3	-1.1	0.3	-0.4	-0.4	-1.6	-0.2	-0.7	-0.5
Alcohol intake versus 10 years previously	3.9	5.8	11.2	-2.1	2.6	3.3	2.4	-1.4	2.3	3.2	2.2	2.7	1.8	1.8
Father’s age at death	0.6	0.8	2.5	-0.8	-1.6	-0.2	0.7	1.2	1.0	-0.3	-0.7	-0.1	1.5	0.2
Worrier / anxious feelings	0.5	0.9	4.2	0.8	-2.1	-0.7	0.3	1.7	0.7	-0.3	0.6	0.1	0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	8.9	-2.8	2.2	2.2	0.0	-3.0	-1.0	1.6	0.2	1.4	0.5	-1.0
Falls in the last year	0.6	0.9	1.9	-0.5	-0.1	1.4	0.4	-0.2	0.7	1.0	1.4	1.2	0.9	1.3
Hair/balding pattern: Pattern 3	0.7	1.0	2.9	0.5	-1.0	-1.2	-1.7	-0.1	-0.4	-1.0	-1.7	-0.5	0.2	-1.2
Number of live births	0.5	0.8	2.1	0.5	-1.4	-1.1	-1.3	1.3	0.4	-0.5	-0.3	-0.7	0.5	0.6
Forced expiratory volume in 1-second (FEV1)	3.2	10.8	21.5	-0.3	-0.3	-2.7	-3.9	-1.8	-4.6	-3.4	-4.3	-3.6	-3.5	-4.0
Pulse rate	0.9	1.6	4.3	0.3	0.3	-0.3	-1.5	-1.6	-1.4	-0.8	-2.0	-0.4	-1.2	-2.1
Happiness	0.2	0.2	0.4	-0.6	-0.5	0.6	0.5	0.5	0.4	0.3	-0.5	0.6	0.2	0.4
Noisy workplace	1.8	2.3	4.5	0.1	-1.7	1.2	1.2	1.8	2.1	0.8	1.2	1.4	1.6	2.1
Qualifications: A levels/AS levels or equivalent	1.2	2.5	5.9	-0.4	0.3	-1.5	-1.1	-1.0	-2.2	-1.4	-2.4	-1.7	-1.5	-2.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.5	-0.8	-0.3	-1.5	-1.0	-0.9	-1.6	-1.0	-1.6	-1.1	-0.2	-1.4
Mouth/teeth dental problems: Dentures	1.0	1.8	5.1	1.4	0.6	-0.5	-0.8	0.8	-1.6	-1.8	-0.7	-2.0	-2.3	-0.3
Asthma	1.2	2.3	5.1	-0.1	1.0	1.8	1.7	0.9	2.0	1.8	2.3	1.5	0.9	1.6
Medication: Ibuprofen (e.g. Nurofen)	3.9	5.0	11.5	-2.1	0.2	2.6	1.3	-1.4	2.2	3.0	1.6	3.4	2.7	2.1
Medication: Cholesterol lowering	0.6	1.0	2.9	-1.3	1.7	1.6	0.5	-1.4	0.1	1.1	0.1	0.8	0.0	0.2
Depression (self-reported)	0.5	0.6	1.4	-0.6	-0.8	0.7	0.5	0.0	0.7	0.7	1.0	0.9	1.2	0.6
Medication: Lansoprazole	0.3	0.3	1.8	-0.1	-0.1	-0.3	-0.9	-0.8	-0.2	0.3	-1.4	0.4	-0.3	-0.2
Prospective memory result	1.5	1.8	4.0	1.4	-1.4	-0.2	1.9	0.6	1.8	0.7	2.0	0.9	1.7	0.9
Lung cancer (father)	0.4	0.5	1.0	-0.9	-0.9	-0.5	-1.0	0.8	-0.4	-0.7	-0.3	-0.7	-0.8	-0.3
Illnesses of mother	1.1	1.4	3.8	-0.2	0.5	-0.8	-1.1	0.1	-1.6	-1.2	-0.9	-1.3	-1.9	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	13.2	-0.7	-0.5	-2.2	-3.2	-1.2	-3.6	-2.7	-3.4	-2.8	-2.8	-3.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.7	0.3	-0.2	-0.8	-0.2	-0.4	-0.4	-0.0	-0.2	-0.9	-0.2
Impedance of arm (left)	0.6	2.7	6.0	2.2	-0.2	-2.1	-1.6	0.8	-1.5	-2.4	-0.3	-2.4	-1.1	-1.5
Arm fat mass (right)	1.7	7.0	16.9	-1.9	2.3	4.1	2.6	-0.8	2.4	3.5	2.4	3.2	1.1	3.0
Trunk predicted mass	1.3	7.3	41.6	-0.9	6.5	1.9	1.4	-2.2	-2.3	0.4	0.1	-0.6	-4.7	0.5
Standing height	2.9	28.9	104.0	2.8	9.9	-1.4	-1.0	-2.3	-6.9	-3.9	-1.1	-5.6	-10.2	-2.0
Length of working week for main job	2.6	2.8	6.7	0.0	-1.9	0.8	1.9	2.4	2.6	0.9	1.4	0.9	1.5	2.1
Exposure to tobacco smoke at home	0.8	0.8	4.9	-1.1	-1.2	-0.2	0.2	0.6	0.8	0.4	0.4	0.4	2.2	0.3
Breastfed as a baby	0.4	0.5	1.8	0.6	0.7	0.4	0.6	0.8	0.5	0.2	0.9	0.2	0.1	1.4
Tense / ‘highly strung’	1.3	2.2	4.3	-0.1	-1.3	0.8	1.1	1.4	2.1	1.4	1.5	1.6	1.8	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	10.0	0.4	-3.2	-1.8	-1.3	0.1	-1.3	-1.7	-1.4	-0.9	0.6	-1.7
Hair/balding pattern: Pattern 4	0.5	1.3	4.1	1.6	-2.0	-1.1	-0.1	0.3	-0.1	-1.5	-0.3	-1.1	0.2	-1.6
Birth weight of first child	1.6	2.9	9.7	1.6	1.2	-1.6	-0.3	1.0	-1.5	-2.0	-0.3	-2.6	-3.1	-1.0
Peak expiratory flow (PEF)	1.6	3.8	8.5	-0.7	0.5	-1.5	-2.8	-1.1	-2.9	-1.6	-2.7	-1.9	-2.0	-1.7
Pulse wave reflection index	0.3	0.4	1.7	0.6	-1.3	-0.1	-1.2	0.4	-0.1	-0.3	-0.3	-0.2	0.5	-0.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.8	-1.0	1.3	1.9	1.1	-0.6	0.5	1.3	0.8	1.4	0.3	0.6
Loud music exposure frequency	1.8	2.0	4.3	1.3	-1.3	-1.6	-1.3	1.7	-0.9	-1.9	-0.3	-2.1	-1.0	-1.2
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	11.0	-1.6	0.2	-1.7	-2.6	-2.5	-3.3	-1.5	-3.0	-1.6	-1.5	-3.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.5	1.3	1.8	0.5	0.7	2.0	0.5	0.4	2.0	-0.3	-0.9	2.4
Blood clot in the leg (DVT)	0.5	0.7	2.9	-1.7	0.8	0.9	0.5	-0.9	-0.6	0.5	-0.3	0.6	-0.8	-0.7
Medication: Paracetamol	3.2	5.4	12.5	-3.2	0.9	3.0	0.5	-3.1	1.0	3.2	1.1	3.5	1.7	0.9
Headache pain in last month	1.5	2.6	8.6	-2.0	0.8	1.0	-1.8	-2.9	-1.9	0.5	-1.6	0.6	-1.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.2	-0.2	-0.6	-0.7	0.1	0.4	-0.6	-0.7	-1.1	-0.6	-0.2	-0.6
Glaucoma (self-reported)	0.6	0.7	2.9	0.4	1.6	-0.4	-0.7	-0.2	-0.4	-0.4	-0.3	-0.8	-1.7	0.2
Gout (self-reported)	1.4	2.0	4.2	-0.3	1.3	1.2	1.6	-0.1	1.9	1.6	1.7	1.5	0.5	2.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	1.2	-0.2	-0.8	-0.5	0.5	-0.5	-1.0	-0.2	-1.1	-0.8	-0.6
Medication: Amlodipine	0.4	0.5	1.3	1.1	-0.4	-0.3	0.4	1.1	1.1	-0.2	0.8	-0.0	0.1	0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.4	0.8	-0.6	-0.5	-0.2	-0.6	-0.1	-0.3	-0.1	-0.8	-0.8
Birth weight	0.5	1.0	5.8	2.4	0.8	0.5	-0.0	0.1	0.1	-0.4	1.1	-0.8	-1.4	0.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.6	1.4	-1.3	-0.8	0.5	1.9	1.1	-0.4	1.9	-0.5	0.5	1.0
High blood pressure (siblings)	0.6	0.8	2.8	-0.3	1.7	0.6	1.1	-0.8	0.3	1.2	0.7	0.9	0.4	1.0
Forced vital capacity (FVC), Best measure	2.8	10.1	20.4	0.0	0.3	-2.7	-3.8	-1.3	-4.5	-3.5	-3.5	-3.8	-4.0	-3.6
Body fat percentage	1.8	7.2	15.8	-1.4	1.5	4.0	2.2	-0.7	2.7	3.6	2.7	3.5	2.0	3.2
Leg fat percentage (right)	3.3	11.9	25.4	-2.5	2.3	5.0	2.7	-2.0	2.9	4.8	2.7	4.9	2.3	3.7
Arm fat-free mass (right)	1.2	6.1	34.9	-0.7	5.9	2.7	1.9	-1.9	-1.0	1.3	1.0	0.4	-3.2	1.6
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.4	-0.3	0.2	-0.7	-0.5	-0.5	-0.1	-0.7	-0.1	-0.0	-0.8
Comparative body size at age 10	2.2	6.0	14.1	-2.0	-1.9	2.6	1.7	0.1	3.8	3.0	1.2	3.1	3.4	1.7
Number of full brothers	0.2	0.3	0.9	-0.3	0.0	-0.1	0.2	-0.8	0.0	0.7	0.1	0.7	0.9	-0.3
Worry too long after embarrassment	0.1	0.2	0.9	0.3	-0.9	0.3	-0.6	-0.0	-0.2	-0.2	-0.5	0.1	0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	4.0	0.2	-2.0	-0.3	-0.1	1.4	0.3	-0.6	0.3	-0.3	1.2	0.6
Wheeze or whistling in the chest in last year	1.3	2.3	4.4	-0.9	0.2	1.9	1.6	0.3	1.9	1.7	1.3	2.1	1.6	1.7
Number of children fathered	0.9	1.1	2.7	1.2	-1.6	-1.4	-0.8	1.3	0.2	-0.8	-0.1	-0.8	1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.7	1.4	-1.3	0.1	-0.6	1.9	0.4	-0.9	0.3	-1.0	-0.0	-0.3
Age at first live birth	0.3	0.6	4.2	-0.1	2.0	-0.1	0.3	-1.1	-0.5	0.1	-0.1	-0.3	-0.5	-0.3
Pulse wave peak to peak time	0.1	0.1	0.4	-0.3	0.4	-0.1	0.6	0.1	-0.2	-0.1	-0.2	-0.3	-0.0	0.0
Health satisfaction	1.7	2.2	4.5	-0.9	2.0	2.1	1.4	-0.9	0.8	1.7	2.1	1.7	0.6	1.1
Shortness of breath walking on level ground	1.6	1.9	8.0	0.8	0.8	0.8	1.9	1.9	1.3	0.6	2.8	0.2	0.4	1.3
Qualifications: College or University degree	1.5	4.9	10.3	0.7	-0.3	-1.7	-1.8	0.5	-2.4	-2.6	-3.1	-2.9	-3.2	-2.4
Eye problems/disorders: None of the above	0.4	0.5	2.4	-0.6	0.1	0.2	-0.5	-1.6	-0.7	0.5	-1.0	0.6	0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.2	0.5	0.2	0.2	0.4	1.1	1.1	0.5	1.5	0.2	0.4	0.8
Emphysema/chronic bronchitis	0.3	0.3	1.2	0.1	0.7	1.1	0.1	0.3	0.5	0.3	0.9	-0.0	0.3	0.5
Medication for pain relief, constipation, heartburn	3.9	6.7	15.4	2.8	-1.4	-3.5	-1.3	2.9	-1.7	-3.6	-1.6	-3.9	-2.1	-2.0
Neck or shoulder pain in last month	0.7	1.0	3.1	0.0	1.3	1.8	0.2	-0.9	0.2	1.2	0.9	1.3	-0.5	0.9
Medication: Blood pressure	0.2	0.3	0.6	-0.3	0.6	0.7	-0.1	-0.6	0.4	0.7	0.8	0.8	0.2	0.6
Angina (self-reported)	1.1	1.4	2.8	-1.1	0.8	1.4	1.7	-0.9	1.0	1.5	1.1	1.2	1.3	0.3
Migraine (self-reported)	1.1	1.3	4.3	-2.1	0.8	1.3	0.6	-1.6	0.0	1.5	-0.3	1.5	0.8	0.1
Medication: Ibuprofen	3.7	4.5	10.9	-2.8	0.1	2.4	0.7	-2.3	1.3	2.8	1.0	3.3	2.5	1.5
Medication: Allopurinol	0.8	1.0	2.1	-1.1	0.9	0.6	1.1	-1.1	1.0	1.3	0.8	1.5	0.8	0.7
Medication: Omeprazole	0.3	0.3	2.5	-0.1	-0.8	-0.5	0.1	-0.1	0.0	-0.1	0.1	0.1	1.6	-0.6
Medication: Seretide 50 evohaler	0.8	1.0	3.4	0.3	0.2	0.6	0.5	0.8	1.1	0.9	0.9	1.0	1.4	1.8
Mean time to correctly identify matches	0.4	0.7	2.0	-0.8	-0.1	1.4	0.9	0.7	1.1	0.8	0.6	0.9	0.5	0.9
Heart disease (mother)	0.5	0.6	2.2	-1.5	-0.5	-0.0	0.2	-1.0	0.5	0.7	-0.4	0.7	1.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.7	0.2	-1.3	-0.2	-0.8	0.2	0.4	0.1	-0.0	0.5	0.2	-0.7
Whole body fat mass	1.5	6.4	15.8	-1.3	2.8	4.0	2.3	-1.0	1.9	3.2	2.4	3.0	0.6	3.1
Leg fat mass (right)	2.2	8.6	21.2	-2.1	3.1	4.6	2.5	-2.0	2.0	4.0	2.3	3.8	0.9	3.2
Arm predicted mass (right)	1.3	6.5	37.3	-0.5	6.1	2.7	1.8	-1.9	-1.2	1.1	0.9	0.2	-3.7	1.5
Pulse rate, automated reading	2.2	7.0	16.4	-0.2	-1.2	-1.5	-3.8	-2.8	-3.2	-1.9	-4.0	-1.1	-1.6	-4.0
Alcohol intake frequency.	4.8	11.1	20.8	-3.1	3.7	4.1	2.6	-2.6	2.2	4.5	2.5	4.6	2.4	3.3
Comparative height size at age 10	3.2	17.6	110.2	-0.7	10.5	3.7	3.1	-2.6	-1.3	2.3	3.1	0.7	-5.1	3.0
Number of full sisters	0.8	0.9	2.7	0.4	-1.1	-0.6	-1.2	-0.1	-0.9	-0.9	-1.4	-0.8	0.2	-1.6
Suffer from ‘nerves’	0.4	0.7	2.3	0.3	-1.0	0.1	1.2	0.8	0.8	0.4	0.8	0.8	1.5	0.4
Overall health rating	2.2	4.6	8.9	-1.7	1.3	1.9	1.4	-1.2	1.9	2.9	2.8	3.0	2.9	1.7
Chest pain or discomfort	4.6	6.6	11.9	-1.1	1.2	2.5	3.5	-0.8	2.7	3.4	3.2	3.2	2.7	2.1
Had major operations	2.9	3.4	6.8	0.9	-1.3	-1.5	-1.6	1.7	-1.7	-2.6	-1.5	-2.5	-2.1	-2.1
Age at last live birth	0.8	1.1	7.0	-0.1	2.6	1.1	1.5	-0.6	0.3	0.6	0.9	0.0	-0.3	0.4
Family relationship satisfaction	0.6	0.7	2.2	-1.1	0.3	1.5	1.2	0.1	0.5	0.9	0.6	1.3	0.1	0.2
Leg pain on walking	0.9	1.1	5.8	-0.8	2.4	0.9	0.7	-0.7	-0.8	0.1	-0.7	-0.7	-1.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	-1.3	-1.4	-0.2	-0.8	-0.5	-0.5	0.1	-1.1	0.6	1.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.9	-0.8	-0.3	0.2	0.6	0.9	1.3	0.9	1.2	0.6	1.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	-0.3	0.3	-0.0	0.0	0.6	0.2	0.0	0.4	0.1	-0.5	0.4
Medication: Aspirin	3.5	4.6	7.9	-2.1	2.5	2.6	1.8	-2.4	1.1	2.8	1.6	2.7	1.1	2.0
Supplements: Vitamin C	0.4	0.4	2.2	0.5	-0.0	-0.2	0.3	0.6	0.7	0.1	1.1	0.1	0.2	1.5
Knee pain experienced in last month	0.2	0.4	1.6	-1.3	0.7	0.8	0.1	-0.7	0.0	0.6	0.4	0.3	0.6	0.0
Hypertension (Self-reported)	0.3	0.8	1.9	0.5	1.2	1.0	0.4	0.1	0.9	1.0	1.4	0.8	-0.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.1	-0.1	0.0	0.7	0.8	0.0	-0.2	-0.5	-0.4	0.1	-0.4
Illnesses of father: Heart disease	0.2	0.2	1.0	0.3	1.0	0.5	0.5	-0.0	0.1	0.4	0.9	0.2	-0.1	0.2
Illnesses of siblings: Diabetes	1.1	1.4	3.9	-1.7	2.0	1.4	-0.1	-1.8	-0.8	0.9	-0.6	0.4	-1.1	-0.6
Smoking status: Previous	1.7	2.6	6.5	2.5	-1.7	-1.6	-1.0	1.9	-0.3	-2.2	0.3	-2.5	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.5	20.9	-1.0	3.8	-1.0	-1.0	-2.1	-3.8	-1.5	-1.7	-2.0	-4.6	-2.3
Whole body fat-free mass	1.0	5.7	32.6	-1.1	5.7	2.1	1.4	-1.9	-1.8	0.7	0.2	-0.3	-3.9	0.7
Leg fat-free mass (right)	0.5	2.7	14.8	-1.0	3.9	1.7	1.1	-1.1	-1.0	0.6	0.2	-0.2	-2.4	0.7
Arm fat percentage (left)	2.0	7.8	14.9	-2.1	0.3	3.9	2.2	-0.3	3.3	3.7	2.4	3.8	2.9	3.0
Average weekly red wine intake	4.3	6.3	13.8	1.9	-0.1	-2.6	-2.2	1.4	-2.6	-3.2	-2.1	-3.7	-3.4	-2.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.9	0.6	0.6	-0.0	-1.2	-1.4	-1.7	-0.8	-0.7	-0.5	-1.0	-1.1
Mood swings	3.4	6.1	13.7	-2.2	-1.4	2.2	2.0	0.1	2.7	2.9	2.3	3.4	3.7	2.1
Loneliness, isolation	0.6	0.8	3.3	-1.1	-0.9	-0.1	-0.3	-0.8	-0.8	-0.3	-1.3	0.2	-0.3	-1.8
Long-standing illness, disability or infirmity	1.7	2.7	5.3	-1.4	1.7	2.3	1.0	-0.1	1.3	2.0	2.2	1.8	1.2	1.7
Ever had bowel cancer screening	1.8	2.1	9.1	0.2	0.1	-1.3	-3.0	-1.2	-1.6	-1.2	-1.4	-1.1	-1.0	-1.5
Diabetes diagnosed by doctor	2.7	4.5	9.1	-1.4	2.1	3.0	1.9	-2.0	1.8	3.0	1.7	2.7	1.5	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.8	1.1	-0.4	-0.4	-0.9	0.5	-0.4	-1.0	-0.8	-1.4	-0.6	-0.5
Friendships satisfaction	0.9	1.1	2.9	0.1	-0.6	-0.4	-0.6	0.5	-1.4	-1.3	-1.3	-1.0	-1.7	-1.5
Qualifications: nursing, teaching	3.9	6.1	11.8	0.6	0.3	-1.3	-2.8	-1.1	-3.4	-2.6	-3.0	-2.8	-3.3	-3.1
Commuting to job workplace: Walk	0.4	0.5	2.6	-0.2	0.7	0.4	-0.5	-1.6	-0.8	-0.1	-0.6	0.0	0.1	-0.5
Eye problems/disorders: Cataract	0.3	0.4	0.9	0.7	0.4	0.0	0.3	0.9	-0.0	-0.7	0.4	-0.8	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	0.1	1.8	0.4	-1.8	-1.7	-1.4	-0.2	-1.0	-0.5	-1.4	-0.1
Medication for cholesterol	2.8	4.3	7.6	0.5	0.3	-1.9	-2.6	-0.5	-2.8	-2.3	-2.1	-2.4	-2.7	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	-0.8	0.5	0.1	-0.3	-0.3	-0.4	-0.2	-0.4	-0.2	-0.4	-0.6
Back pain experienced in last month	0.6	0.8	2.3	0.4	1.2	0.8	-1.2	-1.0	-1.1	-0.0	-0.5	-0.4	-1.5	-0.5
Mineral and other dietary supplements	1.8	2.4	6.2	-0.3	0.2	1.6	1.7	-0.8	1.7	2.0	1.0	2.5	1.6	1.8
Breast cancer (self-reported)	5.7	6.7	12.6	0.6	0.0	-2.8	-3.5	-0.7	-3.5	-2.9	-2.3	-2.9	-3.1	-3.0
Asthma (self-reported)	1.1	2.2	5.1	-0.0	0.4	1.6	1.7	1.4	2.0	1.6	2.3	1.3	1.1	1.4
Osteoporosis (self-reported)	1.6	1.9	5.6	2.4	-2.0	-0.2	-0.7	2.3	1.4	-0.7	0.6	-0.8	0.5	1.5
Osteoarthritis (self-reported)	1.2	1.6	7.5	0.9	1.5	0.4	-0.5	0.7	-1.5	-1.1	0.0	-1.5	-2.7	0.3
Medication: Aspirin	1.8	2.3	4.4	-1.8	1.7	1.8	1.2	-2.1	0.5	1.9	0.9	1.9	0.9	1.1
Medication: Gliclazide	0.5	0.6	1.7	0.3	0.1	1.3	-0.0	-0.7	0.7	0.9	0.4	1.0	1.2	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	-0.5	-0.7	-1.2	-1.0	0.5	-0.6	-0.8	-0.9	-0.8	0.1	0.0
Smoking status: Current	0.6	0.9	2.5	-1.0	-1.0	0.8	0.4	0.0	1.2	1.0	0.5	1.3	1.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	13.8	-0.6	-3.7	-1.8	-2.7	-0.0	-0.5	-1.2	-1.9	-0.7	0.8	-1.1
Whole body water mass	1.0	5.7	32.8	-1.1	5.7	2.2	1.5	-1.9	-1.7	0.7	0.3	-0.2	-3.8	0.8
Leg predicted mass (right)	0.5	2.8	15.6	-1.1	4.0	1.8	1.3	-1.2	-1.0	0.7	0.3	-0.1	-2.4	0.8
Arm fat mass (left)	1.7	7.1	16.8	-2.0	2.5	4.1	2.4	-1.0	2.3	3.5	2.3	3.2	1.0	3.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.3	-1.0	1.3	1.5	-0.3	-1.5	-0.4	0.8	0.2	0.7	-0.7	-0.2
Average weekly champagne plus white wine intake	0.9	1.3	3.1	1.8	-0.3	-1.2	-1.2	0.8	-0.7	-1.5	-0.5	-1.7	-1.1	-0.3
Miserableness	1.3	2.2	6.1	-2.4	0.1	2.5	0.5	-1.8	0.2	1.6	-0.2	2.1	1.4	-0.0
Guilty feelings	0.7	1.0	3.1	-1.8	0.4	1.0	0.3	-1.6	-0.3	0.9	0.1	1.4	1.2	-0.0
Wears glasses or contact lenses	1.0	1.2	2.4	1.4	-1.2	-1.6	-1.4	0.8	-0.7	-1.3	-0.9	-0.8	-0.4	-0.8
Ever taken oral contraceptive pill	1.3	1.5	4.4	-2.0	0.9	0.5	-0.0	-2.1	-0.9	0.9	-1.3	0.9	0.2	-1.6
Hearing aid user	2.2	2.4	5.3	-0.4	-1.5	1.7	1.6	0.8	2.1	1.4	1.5	1.8	2.3	1.1
Mother’s age at death	0.6	0.7	2.6	1.2	-1.6	-0.5	-0.5	0.9	0.3	-0.9	-0.9	-0.7	0.1	-0.8
Financial situation satisfaction	0.4	0.4	1.5	0.3	-0.8	-0.8	-0.3	1.2	-0.4	-0.9	-0.5	-0.6	-0.6	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	0.0	0.2	-0.4	0.5	0.5	-0.1	-0.3	-0.4	-0.2	-0.1
Commuting to job workplace: Public transport	1.1	1.3	4.3	0.6	-0.4	-1.1	-0.7	-0.1	-1.3	-1.5	-0.9	-1.3	-1.2	-2.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.2	0.1	-0.3	-0.8	-0.1	-0.1	-0.4	-0.1	-0.5	-0.8	-0.0
Medication: Blood pressure	2.6	5.0	8.7	-1.3	1.6	2.1	2.9	-0.6	2.6	3.0	2.3	2.9	1.6	2.5
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.8	0.2	1.3	-0.5	0.3	0.3	-0.6	-0.7	0.3	-1.1	-1.4	-0.0
Supplements: Fish oil (including cod liver oil)	3.9	5.0	11.5	0.6	-0.6	-2.6	-2.5	0.9	-2.6	-3.0	-1.8	-3.4	-2.2	-2.4
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.5	0.7	0.7	0.1	-0.3	0.3	1.0	0.3	0.9	0.1	0.3
Medication: Bendroflumethiazide	0.8	1.2	2.6	-1.3	1.5	1.4	0.3	-1.3	0.2	1.5	-0.0	1.6	0.2	0.9
Medication: Paracetamol	3.0	4.7	10.6	-2.9	1.1	2.8	0.6	-3.2	0.6	2.9	1.0	3.3	1.6	0.6
Medication: Lisinopril	2.5	3.3	8.1	-0.2	1.4	2.2	1.0	-0.1	1.9	2.4	2.0	2.3	1.4	2.8
Medication: Atorvastatin	1.0	1.3	2.9	-0.3	-0.3	1.3	0.8	0.4	1.4	1.2	1.7	1.1	1.7	0.8
Illnesses of father: High blood pressure	0.3	0.4	1.3	-1.1	-0.0	0.3	-0.2	-1.0	-0.5	0.4	-1.0	0.5	0.2	-0.1
Alcohol drinker status: Never	1.4	1.7	4.1	-0.2	2.0	1.8	1.3	-0.8	0.8	1.5	1.6	1.3	0.4	1.3
Ever smoked	0.8	1.4	3.6	1.6	-1.3	-1.2	-1.1	1.3	-0.1	-1.6	-0.2	-1.9	-0.2	-0.7
Basal metabolic rate	1.1	6.1	34.2	-1.4	5.8	2.7	1.7	-2.1	-1.3	1.3	0.6	0.4	-3.4	1.2
Leg fat percentage (left)	3.0	10.9	23.9	-2.3	1.9	4.9	2.7	-1.5	3.0	4.6	2.7	4.6	2.3	3.5
Arm fat-free mass (left)	1.2	5.9	33.9	-0.6	5.8	2.5	1.8	-1.8	-1.4	1.0	0.7	0.1	-3.6	1.2
Number of operations (self-reported)	0.5	0.8	2.0	0.7	-0.9	-0.7	-1.3	0.9	-0.5	-1.2	-0.8	-1.4	-0.7	-0.2
Average weekly beer plus cider intake	1.3	1.9	4.3	-0.7	1.2	1.4	1.0	-1.6	0.6	1.7	2.1	1.5	1.4	1.2
Irritability	0.4	0.7	3.8	-0.1	-1.9	1.1	0.2	0.6	0.8	0.4	0.3	0.9	0.4	0.0
Risk taking	3.4	5.0	10.7	3.3	-0.8	-1.8	-1.9	1.8	-2.1	-3.2	-0.6	-3.2	-2.5	-1.4
Ever had prostate specific antigen (PSA) test	3.9	4.5	8.9	0.9	-1.1	-2.5	-3.0	-0.5	-2.2	-2.3	-2.3	-2.3	-2.0	-2.7
Fractured/broken bones in last 5 years	0.2	0.2	0.7	-0.1	0.5	0.1	-0.8	-0.7	-0.8	-0.2	-0.4	-0.1	-0.2	0.1
Age started oral contraceptive pill	0.2	0.2	0.9	0.2	0.8	0.5	-0.4	0.3	0.2	-0.1	0.0	-0.0	-1.0	0.2
Diastolic blood pressure, automated reading	1.2	3.6	8.7	-1.5	-1.3	1.9	0.2	-0.4	1.9	2.2	1.2	2.9	2.9	2.1
Ever depressed for a whole week	1.0	1.2	3.3	-0.6	0.4	-0.4	-0.5	-1.3	-1.8	-0.6	-1.6	-0.1	-0.9	-1.8
Unable to work because of sickness or disability	0.7	0.9	2.8	-0.7	-0.8	0.3	0.5	0.4	1.1	1.1	1.1	1.3	1.7	0.6
Commuting to job workplace: Cycle	1.5	1.8	4.0	1.9	-0.2	-0.8	-0.6	-0.0	-1.6	-1.7	-0.9	-1.9	-2.0	-1.2
Myopia	0.5	0.8	2.7	-0.4	0.1	-0.5	-1.6	-1.2	-1.1	-0.3	-1.1	-0.3	0.2	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.2	6.9	0.3	-1.5	-2.0	-1.6	-0.2	-2.1	-2.2	-2.2	-2.0	-0.8	-2.6
Cholesterol lowering medication	1.1	1.7	3.6	0.4	0.5	1.3	1.2	-0.1	1.6	1.5	1.9	1.6	1.2	1.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.7	0.0	-0.1	-0.1	-0.2	-0.7	-0.2	0.1	0.2	0.3	1.3	-0.5
Pain experienced in last month	1.1	1.8	4.7	1.1	-1.6	-1.6	1.6	2.2	1.6	-0.3	0.9	0.0	1.3	0.9
Supplements: Calcium	2.2	2.4	6.2	2.3	-0.6	-1.1	-1.3	2.3	-0.4	-2.0	0.2	-2.5	-1.4	-0.1
Basal cell carcinoma (self-reported)	1.1	1.4	2.5	0.9	-1.4	-1.1	-1.6	0.7	-0.7	-1.4	-1.4	-1.3	-0.5	-1.2
Heart attack/myocardial infarction (self-reported)	2.5	3.3	5.9	-1.3	1.3	2.1	2.4	-0.5	1.9	2.2	2.1	2.1	1.3	1.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.9	-1.4	0.5	0.8	0.7	-0.3	-0.1	0.6	0.0	0.7	-0.3	-0.5
Heart disease (siblings)	2.5	3.1	5.3	-1.1	2.3	1.9	1.6	-1.3	1.2	2.2	2.0	2.1	0.5	2.1
Alcohol drinker status: Previous	1.4	1.6	3.2	-0.7	-1.1	0.9	0.7	0.7	1.8	1.5	0.6	1.8	1.8	1.4
Pack years of smoking	0.3	0.5	3.5	-0.2	-0.4	0.4	0.7	-0.1	0.6	0.5	-0.2	0.7	1.9	-0.2
Impedance of whole body	0.5	2.5	7.3	2.7	0.8	-1.9	-1.3	0.4	-1.6	-2.0	0.2	-2.1	-1.6	-0.8
Leg fat mass (left)	2.1	8.0	20.2	-1.9	2.9	4.5	2.6	-1.7	2.0	3.8	2.3	3.5	0.9	3.1
Arm predicted mass (left)	1.2	5.9	34.0	-0.4	5.8	2.5	1.8	-1.6	-1.1	1.1	1.1	0.2	-3.6	1.4