Hub : Genes

MYO6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2130	0.0560	9.1e-13	0.067	0.121	0.099	0.123	0.099	1.3e-08	1.7e-14	4.8e-12	8.8e-15	4.7e-12
2	GTEx	Artery Aorta	0.1530	0.0700	4.6e-04	0.047	NA	0.066	NA	0.087	1.3e-03	NA	1.6e-04	NA	1.6e-05
3	GTEx	Artery Tibial	0.0703	0.0355	4.3e-03	0.014	NA	0.015	NA	0.013	2.7e-02	NA	2.3e-02	NA	3.2e-02
4	GTEx	Brain Cerebellar Hemisphere	0.4420	0.0990	1.4e-06	0.304	NA	0.311	NA	0.321	1.6e-08	NA	1.0e-08	NA	5.3e-09
5	GTEx	Brain Cerebellum	0.3360	0.0830	2.1e-07	0.210	NA	0.322	NA	0.231	7.7e-07	NA	2.9e-10	NA	2.0e-07
6	GTEx	Heart Left Ventricle	0.0875	0.0436	4.6e-03	-0.004	NA	-0.005	NA	-0.004	6.2e-01	NA	7.7e-01	NA	5.6e-01
7	GTEx	Lung	0.0900	0.0309	7.8e-06	0.076	NA	0.077	NA	0.066	1.8e-06	NA	1.6e-06	NA	9.4e-06
8	GTEx	Nerve Tibial	0.1211	0.0432	2.8e-05	0.021	NA	0.062	NA	0.051	1.2e-02	NA	3.4e-05	NA	1.6e-04
9	GTEx	Skin Not Sun Exposed Suprapubic	0.1120	0.0500	3.3e-03	0.033	NA	0.036	NA	0.043	6.2e-03	NA	4.7e-03	NA	2.1e-03
10	GTEx	Thyroid	0.1210	0.0370	1.7e-07	0.108	NA	0.121	NA	0.117	1.2e-08	NA	1.5e-09	NA	3.2e-09
11	ROSMAP	Brain Pre-frontal Cortex	0.0913	0.0290	1.8e-07	0.067	0.063	0.077	0.067	0.069	5.5e-09	1.6e-08	4.1e-10	5.7e-09	2.8e-09
12	TCGA	Prostate Adenocarcinoma	0.0400	0.0169	1.8e-04	0.030	0.049	0.031	NA	0.030	4.2e-04	7.0e-06	3.2e-04	NA	3.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.6	2.5	5.8	-1.9	0.7	1.3	0.9	1.9	0.2	2.3	1.1	0.2	2.1	-1.9	-2.4
Bipolar Disorder or Schizophrenia	0.1	0.2	1.3	0.1	1.1	0.1	-0.0	0.3	-0.0	0.7	0.7	0.4	0.4	-0.1	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	4.8	-0.6	-1.3	0.2	0.6	0.2	-2.2	0.5	0.3	1.7	0.0	-0.0	0.0
Depression (Nagel 2018)	0.4	0.7	1.5	-1.2	0.6	0.8	-0.9	-0.4	-0.6	0.3	0.6	-1.1	0.4	-0.9	-1.0
Intelligence (Savage-Jansen 2018)	5.3	16.2	30.2	-3.5	5.1	3.5	2.7	4.3	4.1	4.9	4.9	-0.4	5.5	-4.4	-1.8
Neuroticism (Nagel 2018)	0.4	1.1	4.9	0.0	-0.7	0.2	0.8	0.7	-2.0	1.2	0.1	2.2	-0.5	0.3	0.6
Schizophrenia (2018)	0.5	1.1	2.9	1.7	0.9	-0.9	-0.7	-1.0	-0.2	-1.1	-0.2	0.4	-1.1	1.3	1.7
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	0.4	0.5	-0.2	0.9	0.5	1.4	0.3	0.9	0.7	0.2	-0.4	0.8
Worry (Nagel 2018)	0.8	1.7	7.4	0.6	-1.6	-0.4	1.3	1.4	-1.7	1.5	0.1	2.7	-1.0	0.6	0.0
Alzheimer’s Disease (in mother)	1.1	1.3	4.0	0.2	-2.0	-0.4	-1.1	-1.3	-2.0	-1.1	-1.5	-0.3	-1.2	-0.3	-0.1
Alzheimer’s Disease (in father)	1.5	1.7	4.7	1.6	-2.2	-1.1	1.4	0.9	0.5	-0.6	-0.9	1.7	-1.0	1.8	0.3
Alzheimer’s Disease (including proxy)	1.7	2.4	9.2	0.9	-3.0	-1.3	-1.1	-1.2	-1.9	-1.6	-1.9	0.1	-1.9	1.0	0.2
Crohns Disease (2017)	0.2	0.4	1.6	-0.5	-1.2	-0.1	-0.2	-0.6	-0.8	1.0	0.4	0.3	-0.5	-0.1	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	1.8	-0.9	0.8	-0.1	1.3	0.7	1.4	1.2	1.3	1.1	0.9	-0.6	0.4
Ulcerative Colitis (UC)	1.0	1.9	5.8	-0.6	1.9	-0.3	1.9	1.2	2.4	0.7	1.3	1.4	1.5	-0.5	1.3
Major Depression (MDD)	1.4	1.8	5.8	1.6	0.3	-1.8	-0.3	-1.0	-0.2	-0.9	-0.6	0.7	-1.1	2.4	2.2
Reaction Time	0.5	1.0	2.7	-1.6	-0.4	0.1	-1.6	0.1	-1.1	0.2	0.9	-1.2	0.1	-1.3	-1.2
Verbal and Numeric Reasoning (VNR)	2.6	6.3	11.5	-1.6	2.8	1.9	2.8	2.8	3.1	2.9	3.0	0.7	3.4	-2.3	-1.1
Breast Cancer	0.3	0.8	2.0	0.8	-1.2	-0.6	-0.2	-0.9	-1.4	-1.1	-0.7	0.6	-0.8	0.6	1.0
Ovarian Cancer	2.0	2.7	4.7	-1.5	1.0	1.8	2.1	2.1	1.3	1.5	2.2	1.5	1.2	-1.6	-1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.6	3.9	1.5	-0.4	-2.0	-1.3	-1.4	-0.3	-1.1	-1.1	-1.2	-1.4	1.7	0.4
Bipolar Disorder (2011)	0.7	0.7	2.3	-1.5	1.5	-0.0	-0.8	-0.1	0.2	0.1	0.9	-0.8	0.6	-1.1	0.3
Body Mass Index (BMI) (2010)	1.6	2.2	5.3	2.3	-1.4	-1.3	-0.3	-0.6	-1.5	-1.2	-1.9	1.2	-1.8	1.9	0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.7	-0.5	1.6	0.7	-0.9	-0.8	-0.6	0.0	0.2	-1.1	-0.3	-0.0	1.2
Crohns Disease (2012)	0.6	1.0	2.6	1.3	-1.4	0.3	-0.3	-0.9	-1.2	-0.2	-1.2	0.6	-1.6	0.9	0.7
Mean Putamen Volume	0.2	0.2	0.7	-0.3	-0.6	-0.5	-0.5	-0.3	-0.3	0.1	-0.2	0.2	-0.6	0.5	0.9
Fasting Glucose	1.6	2.0	3.9	-1.5	1.0	2.0	-0.4	1.1	-0.1	2.0	0.8	-1.0	1.6	-1.8	-1.9
HbA1C	1.5	1.7	4.3	-2.0	0.6	0.6	0.6	1.1	-0.4	1.9	1.3	0.1	1.0	-2.1	-1.7
HDL Cholesterol	0.2	0.3	1.2	0.5	0.3	-0.1	-0.7	-0.8	-0.9	-0.4	-0.5	-1.1	-0.2	-0.1	0.1
LDL Cholesterol	0.7	1.2	3.8	-0.0	-1.0	0.1	1.6	1.7	0.5	0.6	1.7	1.9	0.1	0.3	0.7
Lupus	1.0	1.5	5.3	2.1	1.0	-0.4	0.8	-0.0	1.3	-0.5	0.2	1.3	-0.7	1.6	2.3
Neuroticism (2016)	0.3	0.4	2.3	0.1	0.1	-1.2	-0.2	-0.1	-0.2	-0.1	-0.2	0.4	-0.6	0.8	1.5
Primary Biliary Cirrhosis	0.6	0.9	3.6	0.9	-0.1	-0.4	0.2	-0.8	-0.2	-1.0	-0.2	0.6	-1.4	1.2	1.9
Rheumatoid Arthritis	0.1	0.2	0.8	0.4	0.9	0.1	0.5	0.5	0.3	0.8	-0.2	-0.1	-0.1	-0.1	-0.1
Schizophrenia (2014)	0.1	0.3	1.1	1.0	-0.2	-0.3	0.2	-0.2	-0.3	-0.4	-0.2	1.0	-0.6	0.5	0.7
Triglycerides	0.6	1.0	2.6	-1.6	1.2	0.5	0.1	0.8	0.8	0.8	1.3	-0.2	1.3	-1.3	0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-1.3	0.1	0.4	-1.4	-0.4	-1.0	-0.0	0.3	-1.4	0.6	-0.9	-0.9
Ulcerative Colitis	1.7	2.4	7.2	0.3	1.7	-1.1	2.1	0.9	2.7	-0.2	0.6	2.0	0.9	0.3	2.6
Blood Eosinophil Count	0.3	2.3	4.9	0.9	-0.3	-1.6	-2.1	-2.2	-1.1	-2.0	-1.4	-1.1	-1.6	1.2	1.6
Blood Platelet Count	0.1	1.7	8.0	0.3	1.7	-1.3	0.8	0.2	2.2	-1.1	-0.0	0.9	0.4	0.6	2.8
Blood Red Count	0.2	1.7	5.7	-0.5	2.1	1.2	-0.9	0.3	1.0	-0.2	0.2	-2.4	1.2	-2.0	-0.9
Blood White Count	0.3	2.6	10.9	1.1	1.9	-1.0	-1.4	-2.1	0.7	-1.6	-0.1	-1.1	-1.4	1.5	3.3
Heel T-Score	0.4	3.4	8.6	-2.4	2.9	2.0	-0.4	0.1	0.7	0.7	1.9	-1.7	1.9	-2.9	-1.6
BMI	1.4	8.1	16.2	2.1	-1.1	-2.3	-2.9	-3.8	-4.0	-3.7	-3.7	0.0	-3.4	1.6	2.5
Height	4.7	89.6	139.2	-9.4	8.9	10.2	-0.1	6.8	9.5	10.0	8.2	-10.4	11.8	-10.8	-11.7
Waist Hip Ratio (WHR)	0.6	2.7	8.9	-0.5	0.3	-0.1	-3.0	-2.6	-0.3	-2.0	-1.0	-2.8	-0.4	-0.1	1.8
Systolic Blood Pressure	1.6	8.1	15.1	2.8	-2.4	-2.2	-2.7	-3.4	-3.9	-3.3	-2.7	-0.9	-3.7	2.8	1.8
Smoking Status	1.3	3.0	8.8	1.3	-2.4	-2.0	0.6	-0.4	-0.7	-1.0	-1.4	2.3	-2.3	3.0	1.1
Allergy or Eczema	0.4	1.2	3.2	-0.7	-1.4	0.8	1.5	1.1	0.6	0.9	-1.2	0.8	0.8	-0.6	-1.8
Cardiovascular Disease	0.5	1.6	4.1	0.3	-0.5	-0.3	-2.0	-1.8	-1.7	-1.1	-1.7	-1.2	-1.1	0.7	1.2
Hypothyroidism (self reported)	0.2	0.4	1.3	1.1	0.7	-1.0	0.1	0.4	0.3	-0.2	-0.4	0.9	-0.1	0.1	0.7
Respiratory disease	0.8	1.8	5.0	-2.1	-1.7	1.4	-0.5	0.8	-1.1	0.7	0.2	-0.4	1.1	-1.8	-2.2
Type 2 Diabetes (T2D) (2018)	1.0	2.0	7.5	-0.1	0.5	0.7	-2.7	-2.0	-1.4	-0.9	-0.6	-2.6	0.1	-1.1	0.4
Lung FEV1/FVC ratio	1.0	5.0	10.0	1.9	-1.8	-2.0	0.9	-0.7	-2.0	-2.2	-1.5	3.2	-3.1	2.9	2.9
Lung FVC	1.8	9.3	34.1	0.9	2.0	-2.1	4.5	2.5	2.8	-0.7	1.5	5.8	0.5	1.8	5.3
Neuroticism	0.4	0.9	5.0	-0.1	-1.2	0.7	-0.0	0.5	-2.2	1.5	0.2	1.1	-0.5	0.3	-0.0
Chronotype (morning person)	0.2	0.5	2.9	0.6	-0.8	0.4	0.8	0.4	-0.9	-0.8	-0.3	1.7	-0.4	0.3	0.1
Hair Pigment	0.1	2.3	9.4	0.8	0.7	-1.0	-3.1	-2.1	-1.3	-1.2	-0.5	-2.8	-0.8	0.3	-0.0
Tanning	0.0	0.5	2.7	-0.5	-1.6	-0.5	0.5	0.4	0.2	-0.2	0.3	1.0	-0.4	0.7	-0.4
Hand grip strength (left)	1.6	4.3	13.3	-1.7	1.6	-0.0	2.9	2.1	3.7	1.8	2.8	1.6	1.9	-1.2	1.1
Number of treatments/medications taken	0.9	1.6	4.8	1.8	0.8	-0.9	-2.2	-1.2	-0.7	-0.7	-1.4	-1.4	-0.8	0.8	1.5
Average weekly spirits intake	0.4	0.5	2.9	-0.6	0.3	0.3	-0.9	-0.2	0.9	0.1	0.3	-1.7	0.6	-0.3	0.1
Sensitivity / hurt feelings	0.6	1.0	3.4	0.8	-0.4	-0.9	-0.3	-1.0	-1.4	-1.0	-1.8	0.2	-1.0	0.6	1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.8	-0.5	0.4	0.8	-1.3	-0.4	-0.9	-0.4	-0.0	-1.0	0.1	0.2	0.5
Hearing difficulty/problems: Yes	1.8	2.8	8.0	1.2	-1.4	-1.5	-0.7	-1.9	-2.8	-2.0	-1.6	1.0	-2.5	0.9	0.6
Relative age of first facial hair	1.7	3.4	11.4	-0.7	1.4	-1.2	3.4	2.2	2.8	0.7	1.3	2.8	1.4	-0.1	1.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	-1.0	0.6	1.6	0.4	1.3	0.8	1.5	1.3	-0.3	1.6	-1.0	-0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.9	1.7	-0.6	-1.5	-0.3	-0.6	-0.1	-0.6	-1.4	0.6	-1.3	1.4	-0.1
Ever had hysterectomy (womb removed)	1.3	1.4	3.6	1.3	-0.2	-0.8	-1.4	-1.7	-0.4	-0.5	-1.8	-0.8	-1.9	1.1	0.9
Systolic blood pressure, automated reading	1.2	3.4	8.0	1.7	-1.3	-1.8	-1.2	-2.0	-2.7	-1.9	-1.7	0.7	-2.8	2.0	1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	0.8	0.6	0.8	0.7	0.8	-0.2	0.7	0.3	0.2	0.4	-0.8	-1.2
Angina	2.2	2.9	7.1	0.9	-0.7	-1.2	-2.1	-2.7	-1.4	-2.1	-2.2	-1.4	-1.4	1.9	1.2
Medication for hormone replacement therapy	2.5	2.8	7.7	1.7	-1.5	-2.8	0.4	-0.4	-1.5	-1.2	-1.7	2.6	-1.8	1.9	0.8
Vitamin and mineral supplements	0.1	0.2	1.1	-0.2	-0.4	-0.3	0.4	-0.1	-1.1	-0.4	-0.4	0.4	0.2	-0.6	0.1
Supplements: Zinc	0.5	0.5	1.9	-0.3	0.0	0.2	-0.4	0.3	-0.2	0.3	-0.7	-1.1	1.0	-1.2	-1.4
Medication: Co-codamol	1.0	1.1	4.3	-0.9	1.0	1.2	-0.6	1.0	1.6	0.8	0.4	-1.0	2.1	-0.7	-0.2
Medication: Metformin	2.5	3.5	10.9	-0.3	-0.4	0.6	-3.3	-2.9	-3.0	-1.7	-1.1	-2.9	-0.7	-0.6	0.1
Diabetes (father)	0.4	0.5	1.7	0.3	-1.3	-0.1	0.1	-0.2	-1.1	-1.0	-0.7	0.7	-1.1	-0.1	0.4
Diabetes (mother)	0.5	0.6	1.7	0.0	0.0	1.0	0.6	0.6	1.1	0.6	0.5	0.2	1.2	-0.4	-1.3
Severe depression (siblings)	1.1	1.2	5.8	-0.2	2.4	1.1	0.0	0.4	1.1	0.9	1.2	0.5	0.6	0.4	1.8
Pack years adult smoking proportion	0.7	1.0	2.6	1.3	0.7	-1.3	-0.4	-1.1	-0.4	-1.3	-0.3	0.2	-1.1	1.2	1.6
Impedance of leg (right)	0.3	1.6	7.5	-0.9	0.8	1.7	-1.1	0.5	1.4	0.7	0.9	-2.7	0.6	-1.0	-1.3
Leg fat-free mass (left)	0.8	4.3	13.4	-3.0	1.9	1.3	-1.9	-0.2	0.3	0.9	0.9	-3.7	2.4	-2.8	-2.3
Trunk fat percentage	0.9	3.7	11.8	0.3	-0.9	-0.5	-3.4	-2.7	-2.8	-1.8	-2.2	-2.2	-1.8	0.3	-0.6
Hand grip strength (right)	1.6	4.4	11.8	-1.5	1.1	-0.6	3.1	2.2	3.4	1.4	2.7	2.4	2.1	-1.3	1.1
Townsend deprivation index at recruitment	1.3	1.8	3.9	1.3	-0.3	-1.4	-0.9	-1.8	-0.9	-2.0	-0.9	0.3	-1.6	1.5	1.9
Current tobacco smoking	0.7	1.1	3.3	0.3	-0.5	-1.2	-0.8	-1.3	-0.7	-1.0	-1.2	0.4	-1.8	1.2	1.4
Average weekly fortified wine intake	0.2	0.2	0.6	0.8	0.8	-0.6	0.1	0.5	0.4	0.1	-0.6	0.3	-0.4	-0.1	0.1
Maternal smoking around birth	1.1	1.6	6.1	0.6	-2.5	-1.8	0.3	-0.7	-1.5	-0.9	-0.6	1.5	-1.4	1.2	0.5
Fed-up feelings	1.0	1.8	8.1	0.8	-2.2	-0.1	-0.5	-0.9	-2.9	-0.6	-1.2	0.8	-1.5	1.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	5.2	-0.3	1.0	0.3	-2.3	-1.5	-2.0	-0.9	-1.0	-2.2	-0.5	-0.4	-0.2
Relative age voice broke	2.9	4.5	14.9	0.0	1.3	-0.4	3.9	2.9	3.5	0.8	0.6	2.8	1.3	1.0	2.1
Taking other prescription medications	0.3	0.5	2.1	1.0	0.2	-0.2	-1.5	-0.5	-0.2	-0.4	-0.6	-1.1	-0.7	0.4	0.6
Age when periods started (menarche)	2.5	6.0	18.4	-1.1	-0.0	0.9	4.3	4.0	3.7	2.0	2.0	2.3	2.6	-0.6	-1.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	5.4	2.0	-0.3	-0.7	-0.2	-1.3	0.4	-2.3	-0.9	-0.0	-1.3	1.3	2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.5	-0.8	2.3	0.6	1.5	1.4	2.1	1.0	1.5	-0.2	1.4	-1.3	-0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	5.6	-2.4	-1.1	0.5	0.5	0.6	-0.8	1.1	0.8	0.1	0.7	-1.3	-1.4
Qualifications: CSEs or equivalent	2.3	3.1	8.2	2.0	-0.5	-1.0	-0.8	-1.9	-1.0	-2.8	-1.5	0.4	-1.8	2.1	2.9
Serious illness, injury or assault to yourself	1.2	1.4	3.8	-1.6	-0.8	0.8	0.3	1.2	1.1	1.1	0.5	-0.7	1.5	-2.0	-1.6
High blood pressure	0.2	0.6	2.0	-0.3	-0.4	0.4	-0.9	-0.4	-1.4	-0.4	-1.1	-1.0	-0.2	-0.5	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	8.0	0.4	-2.8	0.1	0.9	0.3	0.0	0.3	-1.4	1.0	-0.4	0.6	-1.7
Multivitamins +/- minerals	0.9	1.1	5.1	0.2	1.3	1.1	0.5	1.2	2.3	1.1	1.0	-0.3	1.2	-0.1	-0.4
Stomach or abdominal pain in last month	0.8	1.0	3.7	-0.7	0.0	1.9	-1.1	-0.0	-0.3	0.3	0.0	-1.4	1.0	-1.3	-1.2
Supplements: Glucosamine	1.2	1.5	3.9	-1.1	0.2	1.1	0.8	1.9	2.0	1.2	0.5	-0.1	1.8	-1.1	-1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	4.7	-1.3	0.6	2.2	0.3	0.9	0.4	0.9	0.5	-0.8	0.2	-0.5	-0.9
Medication: Atenolol	0.9	1.1	3.5	0.8	0.8	-0.2	-1.9	-1.6	-1.0	-0.7	-1.0	-1.8	-0.7	0.4	-0.1
Medication: Levothyroxine sodium	0.2	0.4	1.8	1.4	0.8	-0.1	-0.6	-0.0	0.3	0.3	-0.7	-0.7	0.2	0.2	0.5
Sitting height	2.3	16.2	26.2	-4.7	3.3	3.5	0.6	3.1	5.1	3.9	4.1	-4.1	4.9	-4.6	-4.4
Chronic bronchitis/emphysema (father)	0.9	1.1	4.6	0.0	1.3	-0.9	-0.7	-1.2	0.8	-1.4	0.1	-1.0	0.2	0.1	2.1
High blood pressure (mother)	0.7	1.0	2.1	1.4	-0.2	-0.6	0.1	-1.0	-0.7	-1.1	-1.1	0.9	-1.4	1.2	1.3
Body mass index (BMI)	1.3	5.3	15.6	0.7	-0.9	-1.1	-3.7	-3.5	-4.0	-2.5	-2.3	-1.5	-2.1	0.7	1.0
Impedance of leg (left)	0.3	1.3	4.7	-0.9	0.5	1.7	-0.8	0.6	1.4	0.9	0.8	-2.2	0.4	-0.8	-1.3
Leg predicted mass (left)	0.8	4.4	13.3	-3.0	1.9	1.3	-1.9	-0.2	0.3	0.9	0.9	-3.6	2.4	-2.9	-2.3
Trunk fat mass	0.8	3.2	13.1	-1.1	0.1	0.4	-3.6	-2.1	-2.1	-0.9	-1.2	-3.2	-0.4	-1.0	-1.5
Waist circumference	1.5	5.4	21.8	-1.0	-0.0	0.5	-4.7	-3.1	-2.8	-1.5	-1.6	-4.1	-0.5	-1.1	-0.8
Number of incorrect matches in round	1.6	2.7	6.9	2.6	-2.0	-1.1	-1.8	-1.3	-1.9	-1.4	-1.8	-0.8	-1.8	1.6	-0.3
Past tobacco smoking	0.6	1.0	3.1	-0.8	1.2	1.4	-1.3	-0.7	-0.1	0.4	0.6	-1.8	0.5	-1.3	0.3
Alcohol usually taken with meals	0.4	0.6	2.6	-0.4	-0.2	-0.2	1.0	0.9	0.0	1.2	0.0	0.6	0.3	-1.1	-1.6
Nervous feelings	0.6	1.1	2.8	1.7	-0.9	-0.4	-0.4	-0.5	-1.4	-0.3	-1.2	0.9	-1.2	1.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.7	0.0	0.8	1.2	1.1	0.4	0.6	0.3	0.9	0.5	-0.5	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.7	0.6	-0.2	-0.3	-0.4	-0.8	-1.0	-0.6	-0.1	0.8	-1.3	0.7	0.2
Hair/balding pattern: Pattern 2	2.3	2.9	13.4	-0.5	-1.4	-0.6	-2.9	-2.3	-3.7	-0.5	-1.0	-1.4	-1.3	0.7	0.1
Had menopause	0.9	1.1	4.1	-0.7	-0.2	0.3	1.1	1.4	1.6	1.3	-0.4	0.4	0.5	-0.3	-2.0
Had other major operations	0.6	0.7	1.9	1.0	-0.6	-0.3	0.9	-0.2	-0.4	-0.5	-1.4	1.4	-0.9	0.9	1.0
Forced vital capacity (FVC)	3.1	11.9	27.9	-3.5	3.9	1.6	2.9	3.9	5.3	2.6	4.1	0.4	5.2	-3.0	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	12.5	-1.8	3.5	1.2	-0.1	0.7	1.8	1.2	2.1	-2.0	2.2	-2.4	-0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.7	1.6	-0.1	-0.6	-1.3	-1.6	-0.6	-1.3	-1.6	-1.5	-1.1	1.7	1.3
Qualifications: None of the above	1.7	3.6	7.8	2.0	-2.7	-1.3	-1.5	-1.9	-2.0	-1.5	-2.8	0.0	-2.4	2.3	0.2
Financial difficulties in last 2 years	2.0	2.7	6.0	-2.3	1.7	1.8	0.4	0.9	2.1	1.4	2.5	-0.6	2.1	-1.5	0.2
Mouth/teeth dental problems	4.3	6.7	15.9	2.2	-1.5	-2.6	-0.8	-3.3	-1.7	-4.0	-2.4	0.8	-3.1	3.0	3.1
Heart attack	2.3	3.0	8.0	1.2	-0.7	-0.7	-2.8	-2.3	-2.6	-1.2	-1.6	-2.0	-1.5	1.8	0.4
Allergy	0.4	1.0	6.4	0.4	2.5	0.2	0.8	0.4	0.9	-0.1	1.2	0.5	-0.1	0.1	1.4
Pain all over the body in last month	0.7	0.8	3.9	-0.7	0.2	0.3	1.3	1.3	2.0	0.2	0.6	0.5	0.9	0.2	0.4
Diabetes (self-reported)	1.3	1.9	6.7	0.5	-0.2	-0.2	-2.6	-2.3	-1.7	-1.3	-1.2	-2.3	-0.3	-0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.4	-1.0	-1.1	0.2	0.9	0.2	-0.1	0.1	-0.8	1.1	0.5	-0.2	-1.2
Medication: Ramipril	1.5	1.9	7.4	-0.1	2.2	0.1	-2.6	-1.4	-1.0	-0.1	-0.0	-2.7	0.2	-0.4	0.2
Medication: Simvastatin	0.2	0.3	0.8	-0.7	0.6	0.2	-0.8	-0.3	-0.6	0.5	0.5	-0.9	-0.2	-0.5	-0.4
Fluid intelligence score	3.9	8.1	18.2	-2.0	3.5	2.4	2.3	2.9	3.5	3.2	3.1	0.0	4.3	-3.2	-1.4
Illnesses of siblings	0.5	0.7	3.2	-0.6	-0.5	-1.0	1.3	0.7	0.7	-0.3	0.6	1.8	-0.0	0.2	0.6
Neuroticism score	0.5	1.0	3.7	0.9	-0.8	-0.2	-0.4	-0.3	-1.9	0.1	-0.4	1.1	-1.3	1.3	1.4
Weight	1.1	5.5	21.2	-2.7	1.6	1.7	-3.5	-1.2	-0.6	0.4	0.3	-4.6	1.7	-2.9	-2.6
Impedance of arm (right)	0.2	0.8	2.7	0.5	-0.4	-0.1	1.6	1.3	1.6	0.7	0.1	0.6	0.2	0.7	-0.8
Arm fat percentage (right)	1.4	5.4	13.0	1.1	-1.4	-1.4	-3.4	-3.3	-3.6	-2.8	-2.6	-1.1	-2.5	1.4	1.0
Trunk fat-free mass	2.3	13.5	27.9	-4.8	3.2	3.7	-2.1	1.2	1.8	3.0	3.2	-5.3	4.4	-4.8	-4.1
Hip circumference	1.4	6.2	24.2	-2.2	0.4	1.6	-4.3	-1.9	-2.2	0.2	-0.3	-4.9	0.7	-2.5	-3.1
Time employed in main current job	3.1	3.6	8.2	-2.9	1.0	2.4	1.2	1.7	0.3	1.8	2.1	1.1	2.3	-2.8	-1.0
Alcohol intake versus 10 years previously	3.1	4.7	16.1	-0.2	-0.7	0.0	-4.0	-3.5	-2.8	-1.2	-2.2	-3.3	-1.2	0.5	-0.4
Father’s age at death	0.4	0.5	2.1	0.3	-0.7	-0.5	0.8	0.4	-1.1	-0.6	0.2	1.4	-0.7	-0.5	-0.6
Worrier / anxious feelings	0.5	1.0	4.7	0.5	-0.5	-0.1	1.0	1.3	-0.8	1.5	0.8	2.2	-0.3	0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	7.0	-1.1	1.7	0.6	-2.3	-1.3	-0.2	-0.8	-0.1	-2.6	1.2	-0.5	1.1
Falls in the last year	1.6	2.2	9.0	-0.0	-0.6	-3.0	-1.3	-1.7	-1.0	-1.6	-2.4	-0.5	-1.4	0.6	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.2	1.1	-0.2	1.2	1.0	1.2	0.1	0.4	1.2	0.9	0.1	0.1
Number of live births	0.7	0.9	3.3	0.3	-1.1	-1.4	1.1	0.4	0.8	-0.4	-1.1	1.8	-0.0	0.4	1.0
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	18.7	-2.5	3.5	0.8	2.7	3.2	4.3	1.8	2.9	1.0	4.0	-1.9	1.4
Pulse rate	0.9	1.6	3.9	-1.0	1.8	1.1	0.9	0.9	1.8	0.6	2.0	-0.2	1.7	-1.2	0.5
Happiness	0.3	0.3	1.8	-1.3	-0.1	0.3	-0.1	0.5	-1.0	-0.1	-0.3	0.1	0.4	-0.7	-0.4
Noisy workplace	1.4	1.7	6.3	-0.1	-2.5	-1.5	-0.5	-0.4	-2.3	-0.8	-0.6	1.0	-1.9	0.8	0.1
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.5	-1.0	1.9	1.3	1.6	1.7	1.8	1.4	1.8	0.2	2.3	-1.8	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.3	1.4	1.1	-1.8	0.5	-0.2	1.0	-1.4	-1.2	0.3	-0.0	1.0	1.7
Mouth/teeth dental problems: Dentures	2.3	3.9	8.1	-1.4	1.6	1.7	1.6	2.8	2.1	2.6	2.2	0.5	2.1	-2.1	-1.9
Asthma	0.5	1.0	4.2	-0.9	-2.1	0.3	-1.0	-0.2	-1.1	-0.3	-0.4	-0.6	0.5	-1.1	-1.5
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	8.6	2.2	-1.5	-0.6	-2.4	-2.9	-2.2	-2.9	-2.5	-1.0	-2.9	2.1	2.1
Medication: Cholesterol lowering	0.6	0.9	3.0	-1.2	1.1	0.9	-1.1	-0.3	-0.3	0.5	-0.0	-1.7	1.0	-1.2	-0.3
Depression (self-reported)	1.8	2.2	4.3	1.4	-0.8	-1.9	-1.3	-1.6	-1.3	-0.9	-2.1	-0.0	-1.7	1.7	1.8
Medication: Lansoprazole	0.3	0.3	1.0	-0.3	0.8	0.5	0.3	0.2	1.0	0.3	0.1	0.3	0.4	-0.9	0.6
Prospective memory result	5.3	6.5	15.8	4.0	-2.2	-3.1	-0.9	-1.7	-1.4	-2.4	-2.4	0.4	-3.8	3.5	1.9
Lung cancer (father)	0.3	0.3	0.9	-0.9	-0.1	-0.6	0.3	0.8	0.0	0.5	-0.4	0.9	0.6	-0.0	0.4
Illnesses of mother	1.5	1.8	4.4	-1.8	1.0	0.5	0.4	1.2	1.3	1.8	1.8	-0.1	2.1	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	11.8	-2.4	2.5	0.5	2.1	2.6	3.4	1.1	2.3	0.9	3.0	-1.5	1.5
Pulse wave Arterial Stiffness index	0.2	0.2	1.4	0.5	1.2	0.2	-0.5	-0.2	0.1	0.1	-0.1	-0.4	-0.5	0.1	-0.0
Impedance of arm (left)	0.2	0.8	3.2	0.6	-0.4	0.1	1.8	1.2	1.6	0.4	-0.1	0.5	0.1	0.5	-0.9
Arm fat mass (right)	0.9	3.7	14.5	-0.5	-0.3	0.0	-3.8	-2.8	-2.9	-1.6	-1.4	-2.8	-0.9	-0.4	-0.7
Trunk predicted mass	2.3	13.1	27.4	-4.7	3.1	3.7	-2.1	1.2	1.7	2.9	3.1	-5.2	4.3	-4.8	-4.1
Standing height	4.1	40.5	64.0	-7.2	5.2	6.1	0.1	4.7	6.7	6.2	5.4	-7.1	8.0	-7.6	-7.8
Length of working week for main job	1.4	1.6	7.7	-0.1	-1.9	-0.6	-0.5	-0.3	-2.8	0.1	0.0	1.4	-1.9	1.1	-0.2
Exposure to tobacco smoke at home	2.5	2.8	5.6	1.0	-1.7	-2.4	-1.1	-1.8	-1.5	-1.6	-1.9	0.4	-2.0	2.2	1.4
Breastfed as a baby	0.3	0.4	1.5	-0.4	-0.5	0.6	0.6	0.8	-0.0	0.5	-0.3	-0.0	0.4	-1.0	-1.2
Tense / ‘highly strung’	1.1	1.8	6.0	0.9	-1.0	-1.7	-0.5	-0.6	-2.4	-0.4	-1.7	0.9	-1.7	1.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	10.5	2.0	0.4	-1.7	1.6	0.3	0.8	-0.7	-0.7	2.4	-1.7	2.1	3.2
Hair/balding pattern: Pattern 4	0.4	1.0	3.0	1.4	-0.6	-0.5	1.4	0.1	0.4	-0.6	-0.5	1.5	-1.2	1.7	0.5
Birth weight of first child	2.0	3.6	7.7	-1.5	0.5	1.9	1.4	2.3	1.5	2.5	1.9	-0.4	2.3	-2.1	-2.8
Peak expiratory flow (PEF)	1.3	2.9	7.8	-2.5	2.1	0.6	1.2	1.9	2.8	1.3	1.5	0.0	2.2	-1.4	0.7
Pulse wave reflection index	1.0	1.2	3.4	1.8	0.5	-1.1	0.2	-0.4	-0.2	-0.9	-1.2	1.1	-1.4	1.3	1.6
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.7	-1.0	-0.4	1.6	-1.4	-0.3	-0.7	0.2	-0.5	-1.4	-0.3	-0.4	-0.4
Loud music exposure frequency	0.6	0.6	1.7	-0.2	-0.7	-0.1	1.3	1.1	1.0	0.8	-0.3	1.3	0.8	0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	14.4	0.1	3.8	-0.0	0.7	0.9	2.1	0.1	1.2	-0.2	2.1	-0.7	1.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.9	-1.0	-1.3	1.3	-0.5	0.8	-0.9	2.2	0.1	-1.1	0.9	-0.7	-1.8
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.6	0.4	-0.4	-0.9	-0.3	-0.2	0.6	0.7	-1.2	0.2	-0.4	0.5
Medication: Paracetamol	2.0	3.4	10.9	0.8	0.2	-1.2	-3.3	-2.7	-1.3	-2.2	-1.1	-1.9	-1.0	1.3	2.5
Headache pain in last month	1.0	1.7	7.8	-0.9	2.8	0.9	-0.6	0.2	1.1	0.5	1.5	-1.1	1.6	-0.5	1.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.5	0.1	0.3	0.6	0.3	0.4	-0.1	0.7	0.6	0.1	0.0	-0.3
Glaucoma (self-reported)	0.8	0.9	3.6	0.1	1.9	0.5	0.0	0.2	0.8	1.3	-0.4	-0.7	1.3	-1.1	-1.0
Gout (self-reported)	1.0	1.4	3.6	-0.8	-0.7	0.1	-1.9	-1.4	-1.8	-0.7	-0.9	-1.6	-0.7	-0.8	-1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.2	1.1	0.3	-0.4	-0.0	0.3	0.6	0.3	-0.4	0.2	0.1	0.1	0.1
Medication: Amlodipine	0.5	0.7	2.1	0.3	-0.5	1.4	1.2	1.0	-0.1	1.1	0.2	0.8	-0.4	-0.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	-1.8	-0.1	0.6	0.0	0.5	1.2	-0.1	0.2	-0.4	1.6	-1.5	-0.6
Birth weight	0.3	0.7	2.6	-0.1	0.9	-0.2	-0.7	0.4	0.4	1.1	1.2	-1.0	0.3	-0.3	-1.6
Chronic bronchitis/emphysema (mother)	1.8	2.1	6.2	2.0	-2.1	-0.6	-0.1	-0.5	-0.9	-0.7	-1.2	1.0	-2.3	2.5	0.7
High blood pressure (siblings)	0.3	0.5	1.4	0.5	1.2	1.1	-0.5	0.1	-0.4	0.7	0.2	-1.1	0.5	-0.7	-0.2
Forced vital capacity (FVC), Best measure	2.1	7.7	20.2	-3.1	2.8	1.2	2.5	3.4	4.5	1.9	3.2	0.3	4.1	-2.3	0.4
Body fat percentage	1.3	5.0	16.0	0.5	-0.7	-0.7	-4.0	-3.2	-3.2	-2.4	-2.5	-2.3	-2.1	0.6	0.2
Leg fat percentage (right)	1.9	6.7	24.3	0.3	-0.3	-0.1	-4.9	-3.8	-3.6	-2.6	-2.4	-3.3	-2.2	0.3	0.8
Arm fat-free mass (right)	1.7	8.6	25.0	-3.8	2.4	2.6	-2.7	0.1	0.7	1.7	1.7	-5.0	3.0	-4.0	-3.6
Exposure to tobacco smoke outside home	0.1	0.1	0.5	0.2	0.1	-0.5	0.2	-0.1	0.4	0.0	0.5	0.3	0.5	-0.2	0.7
Comparative body size at age 10	1.7	4.6	13.8	1.4	-1.6	-1.6	-1.6	-2.5	-3.7	-3.0	-2.0	0.5	-2.5	1.9	1.4
Number of full brothers	0.4	0.5	1.0	0.9	0.9	0.0	-1.0	-0.8	0.2	-0.8	-0.9	-0.1	-0.1	0.9	0.8
Worry too long after embarrassment	0.3	0.4	1.2	0.4	0.8	0.8	0.3	0.7	0.2	1.1	1.0	0.8	0.0	-0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	1.2	-0.6	-1.4	0.3	0.0	-0.8	-0.2	-1.1	1.4	-1.6	1.9	1.7
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	-1.4	-1.4	-0.1	-1.1	-1.0	-1.6	-0.3	-0.7	-0.5	-0.4	-0.3	-0.9
Number of children fathered	1.1	1.2	3.5	0.1	-1.8	-1.5	1.4	0.1	-0.1	-0.4	-0.8	1.9	-0.7	1.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.4	0.1	0.1	0.3	1.2	0.9	-0.6	1.5	0.6	1.3	0.3	-0.1	-0.7
Age at first live birth	0.5	0.9	3.8	-0.8	-0.0	0.8	-0.1	-0.2	0.5	-0.4	-0.5	-1.6	0.4	-1.6	-2.0
Pulse wave peak to peak time	0.5	0.6	1.5	-1.2	-0.8	0.3	0.6	0.7	0.6	0.5	0.7	-0.0	1.2	-0.8	-0.7
Health satisfaction	1.1	1.5	6.2	-0.4	-0.2	0.6	-2.5	-1.5	-1.3	-0.6	-0.6	-2.3	-0.2	-0.2	-1.0
Shortness of breath walking on level ground	1.1	1.3	4.3	0.2	-2.1	0.3	-1.4	-0.6	-1.5	0.6	-1.6	-0.6	-0.7	0.6	-1.4
Qualifications: College or University degree	2.8	8.9	17.7	-3.1	2.6	2.0	2.9	3.6	2.2	3.8	3.9	1.2	4.2	-3.2	-1.4
Eye problems/disorders: None of the above	0.4	0.5	1.9	0.1	0.7	-1.2	-0.4	-0.4	0.4	-0.6	0.5	-0.3	-0.1	0.8	1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	4.7	1.0	-0.7	-0.7	-1.3	-0.7	-1.1	-0.9	-2.2	-0.5	-0.7	0.7	-0.9
Emphysema/chronic bronchitis	0.4	0.5	1.5	-0.5	-0.6	-0.6	-1.1	-0.7	-1.2	-0.2	-0.4	-1.1	0.1	-0.1	-0.4
Medication for pain relief, constipation, heartburn	2.1	3.6	11.0	-1.2	-0.7	0.9	3.3	3.0	2.1	2.1	0.8	2.3	1.4	-0.7	-1.8
Neck or shoulder pain in last month	0.6	0.8	4.2	-0.6	-0.7	-0.1	-2.0	-0.7	-0.5	-0.2	0.6	-1.7	-0.7	0.4	-0.2
Medication: Blood pressure	0.1	0.3	0.9	0.8	0.1	-0.5	-0.4	-0.4	-0.2	-0.4	-1.0	-0.6	-0.3	0.1	0.5
Angina (self-reported)	2.3	3.0	7.4	1.1	-0.7	-1.1	-2.2	-2.7	-1.4	-2.1	-2.3	-1.5	-1.4	1.9	1.2
Migraine (self-reported)	0.5	0.6	2.1	-0.2	0.8	-0.5	-1.4	-1.1	-0.2	-0.7	0.4	-1.0	0.8	0.2	0.6
Medication: Ibuprofen	3.9	4.7	8.7	1.9	-1.1	-1.2	-2.4	-2.9	-1.7	-3.0	-1.9	-1.0	-2.9	1.9	2.8
Medication: Allopurinol	0.9	1.2	2.7	0.7	-0.1	-0.4	-1.6	-1.6	-1.0	-1.6	-1.0	-1.4	-1.4	0.3	0.1
Medication: Omeprazole	0.6	0.7	2.0	1.4	-0.4	-1.3	-0.0	-0.2	-0.5	-0.9	-0.8	0.4	-1.2	0.8	1.0
Medication: Seretide 50 evohaler	0.4	0.4	1.4	-0.7	-0.3	-0.1	-0.5	-0.3	-1.1	-0.9	-1.2	-0.2	-0.0	-0.9	-0.5
Mean time to correctly identify matches	0.3	0.6	1.9	-0.9	-0.5	0.4	-0.8	0.3	-1.2	0.3	0.8	-0.3	-0.2	-0.9	-1.4
Heart disease (mother)	0.8	1.0	3.0	0.8	0.4	-0.1	-0.6	-0.8	-0.8	-1.6	-1.0	0.1	-1.2	1.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.7	0.0	-1.0	-0.2	-0.3	0.4	-0.3	-0.3	1.0	-0.7	0.9	1.1
Whole body fat mass	0.9	3.7	15.2	-0.7	-0.0	0.0	-3.9	-2.6	-2.5	-1.5	-1.5	-3.1	-0.8	-0.6	-0.7
Leg fat mass (right)	1.2	4.6	19.8	-0.8	0.2	0.2	-4.5	-2.9	-2.6	-1.7	-1.4	-3.6	-0.9	-0.6	-0.2
Arm predicted mass (right)	1.9	9.8	25.8	-4.0	2.6	2.9	-2.6	0.5	1.0	2.2	2.1	-5.1	3.3	-4.3	-3.8
Pulse rate, automated reading	1.1	3.6	9.7	-1.0	3.1	0.0	1.3	1.3	3.1	0.3	2.5	0.9	1.5	-0.5	3.1
Alcohol intake frequency.	2.4	5.6	19.3	-0.4	-0.5	1.2	-4.4	-3.1	-2.7	-2.1	-2.1	-4.2	-1.3	-0.4	-0.3
Comparative height size at age 10	3.9	21.2	79.2	-4.7	2.4	4.0	-4.8	0.3	0.7	3.3	2.1	-8.9	4.0	-5.8	-6.5
Number of full sisters	0.5	0.6	1.5	0.4	1.2	-0.1	1.1	0.4	0.7	0.1	0.4	1.1	1.2	0.4	0.9
Suffer from ‘nerves’	0.6	0.9	2.4	1.6	-0.5	-0.6	-0.4	0.0	-1.2	0.2	-1.1	0.9	-0.9	1.2	1.2
Overall health rating	3.1	6.6	14.7	1.9	-1.5	-1.6	-3.4	-3.5	-2.5	-3.1	-3.8	-2.2	-2.2	2.0	1.4
Chest pain or discomfort	3.7	5.4	10.6	1.8	-2.5	-1.2	-3.2	-3.0	-2.5	-2.3	-3.3	-1.6	-2.3	2.0	0.8
Had major operations	1.7	2.0	5.7	-1.1	-0.0	0.3	2.0	2.4	1.2	1.9	1.0	1.5	1.6	-1.2	-0.6
Age at last live birth	1.3	1.9	8.2	-1.6	-1.0	1.0	-0.9	-0.5	-0.3	-0.0	-0.1	-2.4	0.5	-1.7	-2.9
Family relationship satisfaction	0.6	0.7	2.4	-1.0	0.1	0.3	-1.0	0.1	-1.5	0.8	1.6	-0.8	-0.0	-0.4	-0.7
Leg pain on walking	1.8	2.2	6.1	-1.2	1.3	2.5	-0.7	0.6	0.4	1.2	0.5	-1.9	2.2	-1.7	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	6.5	0.9	0.3	-1.9	0.3	-0.4	0.3	-1.6	-0.4	1.1	-0.2	0.8	2.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	3.1	-0.2	-0.3	-0.7	-0.8	-0.6	-1.8	-0.1	-0.4	0.0	-0.9	0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	-0.1	0.3	-0.1	-0.3	-0.3	-0.4	0.1	0.2	-0.3	-0.6	-0.1	-0.3
Medication: Aspirin	2.2	2.8	9.2	1.0	1.3	-0.6	-3.0	-2.4	-1.8	-1.5	-0.3	-2.9	-1.3	-0.1	0.8
Supplements: Vitamin C	0.2	0.3	1.4	0.0	-1.1	0.2	-0.0	-0.0	-0.3	-0.2	-0.3	0.0	-1.2	0.5	-0.4
Knee pain experienced in last month	0.5	0.7	1.8	0.4	0.1	-0.5	-1.3	-1.3	-0.3	-1.3	-1.1	-1.0	-0.2	0.4	0.7
Hypertension (Self-reported)	0.2	0.4	1.3	-0.1	-0.2	0.5	-0.8	-0.5	-1.0	-0.3	-1.1	-1.1	-0.2	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.7	-1.1	0.8	1.2	0.7	0.8	-0.2	0.0	0.6	0.4	1.3	-1.6	-1.2
Illnesses of father: Heart disease	0.3	0.4	1.3	0.2	0.3	-0.1	-0.8	-1.1	-0.3	0.1	-0.7	-1.1	-0.1	0.7	-0.3
Illnesses of siblings: Diabetes	1.4	1.8	5.7	-1.2	2.4	1.4	-1.3	-0.3	-0.1	1.0	0.9	-2.1	1.5	-1.3	0.2
Smoking status: Previous	0.6	1.0	2.5	1.1	-1.1	-0.9	1.4	1.1	0.4	-0.0	-0.4	1.6	-0.1	1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	3.9	8.2	17.1	-4.0	3.1	2.3	-0.3	2.0	2.8	2.6	2.9	-3.3	4.1	-3.0	-1.7
Whole body fat-free mass	1.7	9.5	22.7	-4.2	2.7	2.8	-2.1	0.6	1.1	2.2	2.3	-4.8	3.6	-4.1	-3.5
Leg fat-free mass (right)	0.8	4.1	10.2	-3.0	1.8	1.4	-1.5	0.0	0.5	1.2	1.1	-3.2	2.5	-2.9	-2.3
Arm fat percentage (left)	1.5	6.1	14.1	1.2	-1.2	-1.4	-3.5	-3.6	-3.8	-3.0	-2.9	-1.3	-2.6	1.3	1.1
Average weekly red wine intake	2.9	4.2	9.0	-1.4	2.0	0.8	2.5	3.0	3.0	1.7	0.7	1.1	2.8	-2.0	-1.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	-0.3	0.5	0.8	-0.0	-0.0	1.4	0.4	1.3	-1.0	0.1	0.3	0.4
Mood swings	2.6	4.7	14.2	1.6	-1.7	-1.4	-1.8	-2.5	-3.8	-1.9	-2.2	0.3	-2.5	2.4	2.4
Loneliness, isolation	0.6	0.8	2.9	-1.0	1.1	0.9	0.3	0.8	0.4	1.1	1.7	0.6	0.5	-0.1	1.0
Long-standing illness, disability or infirmity	1.7	2.6	7.6	-0.6	-0.9	-0.3	-2.8	-2.1	-2.5	-1.0	-2.2	-2.2	-0.9	0.2	0.2
Ever had bowel cancer screening	1.0	1.1	4.5	-0.7	1.7	0.6	0.6	1.0	2.1	0.9	0.6	-0.2	1.4	-0.9	0.2
Diabetes diagnosed by doctor	1.3	2.1	7.5	0.4	-0.1	0.0	-2.7	-2.3	-1.7	-1.4	-1.4	-2.3	-0.3	-0.4	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.4	-1.0	-0.4	0.8	0.8	0.4	0.8	0.6	0.1	0.7	1.2	-0.2	-0.4
Friendships satisfaction	2.4	2.9	6.9	-2.5	0.7	1.5	0.8	1.9	0.8	2.0	2.6	0.5	2.0	-1.7	-1.7
Qualifications: nursing, teaching	4.6	7.1	15.5	-2.1	3.9	2.1	2.0	2.8	3.4	2.7	3.3	0.2	3.0	-3.2	-0.7
Commuting to job workplace: Walk	0.3	0.3	1.7	0.5	1.3	0.5	0.1	-0.5	0.3	-0.4	0.1	-0.8	0.2	0.1	0.2
Eye problems/disorders: Cataract	0.6	0.7	1.9	-0.9	-0.1	1.3	-0.1	0.9	-0.1	0.9	1.1	-0.4	0.9	-0.8	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.7	-1.5	2.4	1.6	-0.6	0.6	1.1	1.3	1.5	-1.7	1.6	-1.5	-0.8
Medication for cholesterol	3.3	5.0	8.7	-2.4	1.4	2.3	1.9	2.5	3.0	2.6	2.5	0.1	2.9	-2.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.9	0.2	1.7	0.8	-0.0	0.8	0.1	0.3	0.2	-0.1	1.0	-0.3	0.6
Back pain experienced in last month	0.5	0.7	2.0	-0.9	0.5	0.8	-1.1	0.1	1.0	0.8	-0.3	-1.2	1.4	-0.3	-0.2
Mineral and other dietary supplements	0.7	0.9	3.9	0.7	-0.1	-0.3	-0.9	-1.6	-2.0	-0.8	-0.4	-0.6	-1.3	0.4	0.4
Breast cancer (self-reported)	1.9	2.2	10.0	-0.3	1.3	0.3	1.5	2.0	3.2	1.0	1.8	0.2	1.6	0.2	1.4
Asthma (self-reported)	0.5	0.9	5.5	-0.7	-2.3	0.1	-0.7	-0.1	-1.2	-0.3	-0.6	-0.1	0.2	-0.8	-1.3
Osteoporosis (self-reported)	0.5	0.6	2.2	0.1	-1.0	-0.6	0.2	0.1	-1.0	0.4	-0.2	1.5	-0.8	1.1	-0.4
Osteoarthritis (self-reported)	3.3	4.3	7.6	-2.7	0.9	2.7	0.9	2.2	1.5	2.5	1.8	-0.6	2.8	-2.2	-2.3
Medication: Aspirin	1.5	2.0	5.1	1.1	1.4	-0.9	-2.3	-1.9	-1.1	-1.5	-0.3	-2.1	-1.2	0.3	1.3
Medication: Gliclazide	0.2	0.2	0.7	-0.3	-0.2	0.1	-0.8	-0.8	-0.4	-0.3	-0.5	-0.3	-0.3	0.1	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	1.3	-0.1	0.2	-0.4	0.8	0.6	0.5	0.2	-0.3	1.1	0.2	-0.1	0.4
Smoking status: Current	0.8	1.3	3.8	0.2	-0.9	-1.2	-0.9	-1.3	-1.2	-1.2	-1.3	0.3	-1.9	1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	15.5	1.2	-0.4	-1.9	2.1	1.0	0.9	-1.7	-0.2	3.4	-0.9	2.0	3.9
Whole body water mass	1.6	9.4	22.8	-4.1	2.6	2.8	-2.2	0.5	1.1	2.1	2.2	-4.8	3.5	-4.1	-3.5
Leg predicted mass (right)	0.8	4.1	11.2	-3.0	1.8	1.4	-1.6	-0.1	0.4	1.1	1.0	-3.3	2.4	-2.8	-2.3
Arm fat mass (left)	0.9	3.9	15.0	-0.5	-0.1	-0.1	-3.9	-2.8	-2.9	-1.7	-1.6	-2.9	-1.0	-0.3	-0.5
Number of self-reported non-cancer illnesses	0.6	1.0	3.1	-0.9	1.8	0.7	-1.5	-0.6	-0.1	-0.4	-0.6	-1.5	1.2	-1.0	0.6
Average weekly champagne plus white wine intake	0.4	0.6	1.5	-0.2	0.8	-0.4	1.2	1.1	1.1	1.2	0.5	0.5	0.2	-0.4	-0.4
Miserableness	0.5	0.8	2.9	-0.3	0.7	0.6	-1.2	-1.1	-1.4	-0.5	0.4	-0.9	-0.3	0.5	1.7
Guilty feelings	0.8	1.2	2.6	0.6	1.6	-0.6	-1.5	-1.3	-0.6	-0.5	0.7	-1.1	-0.9	1.3	1.3
Wears glasses or contact lenses	0.5	0.6	2.5	-0.1	0.0	-0.4	1.6	0.9	1.5	0.3	0.1	1.2	0.3	0.1	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.6	-1.0	1.2	0.1	-0.7	-0.8	0.3	-0.2	0.4	-1.1	0.9	-1.2	0.8
Hearing aid user	2.8	3.2	6.0	1.0	-2.1	-2.3	-1.2	-2.0	-2.4	-1.6	-1.7	0.5	-2.3	2.0	1.0
Mother’s age at death	0.4	0.5	2.3	0.5	-0.0	-1.2	1.0	0.3	0.0	-0.2	-0.4	1.5	0.0	-0.4	-0.5
Financial situation satisfaction	0.5	0.6	2.1	-1.0	-0.6	0.2	1.1	1.5	0.5	0.6	0.6	1.1	0.2	-0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.9	0.8	0.8	-0.1	0.6	-0.3	0.7	0.2	0.1	0.8	-0.8	-0.7
Commuting to job workplace: Public transport	0.7	0.8	3.8	2.0	0.3	-0.4	1.0	0.8	1.7	0.1	-0.0	0.6	0.1	1.0	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	0.7	0.5	-0.8	-0.0	-0.5	0.3	0.1	-1.0	0.1	-0.1	0.2	0.3
Medication: Blood pressure	1.5	2.8	5.9	1.5	-0.8	-0.1	-2.4	-2.4	-2.4	-1.7	-1.8	-1.7	-1.9	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.7	-0.6	0.2	0.7	0.0	0.6	0.7	0.4	-0.4	-0.7	1.0	-0.7	-1.3
Supplements: Fish oil (including cod liver oil)	1.5	2.0	7.3	-0.4	0.8	0.4	2.0	2.4	2.7	1.1	0.9	1.2	1.5	-0.3	-0.1
High cholesterol (Self-reported)	0.2	0.3	1.8	0.0	1.3	0.2	-1.0	-0.0	-0.6	0.2	-0.1	-0.7	0.4	-0.4	0.2
Medication: Bendroflumethiazide	0.4	0.6	2.0	-0.0	0.9	-0.2	-1.4	-1.0	-0.6	0.2	0.2	-1.4	0.4	-0.4	0.4
Medication: Paracetamol	2.0	3.1	10.3	0.8	-0.0	-1.0	-3.2	-2.6	-1.1	-1.9	-0.9	-2.1	-1.2	1.4	2.2
Medication: Lisinopril	2.3	3.0	7.1	1.2	-1.3	-2.1	-1.9	-2.1	-2.0	-1.9	-2.7	-1.3	-1.6	1.0	0.6
Medication: Atorvastatin	2.8	3.5	9.0	1.2	-1.1	-2.1	-1.9	-2.2	-2.2	-1.7	-3.0	-0.6	-1.6	2.2	1.5
Illnesses of father: High blood pressure	0.3	0.4	2.6	0.2	1.6	0.1	-0.2	0.1	0.2	-0.4	0.6	-0.1	0.3	-0.6	1.0
Alcohol drinker status: Never	0.6	0.7	2.8	0.4	-0.1	1.1	-1.2	-0.5	-0.8	0.1	-0.4	-1.7	0.1	-0.4	-1.0
Ever smoked	0.3	0.5	1.4	0.0	-0.9	-1.2	1.0	0.5	0.7	-0.5	-0.5	1.1	-0.1	0.5	-0.6
Basal metabolic rate	1.6	8.7	25.3	-3.9	2.5	2.7	-2.7	-0.0	0.6	1.6	1.8	-5.0	3.2	-3.9	-3.3
Leg fat percentage (left)	1.7	6.2	22.0	0.3	-0.5	-0.1	-4.7	-3.7	-3.6	-2.4	-2.4	-2.8	-2.2	0.5	0.7
Arm fat-free mass (left)	1.9	9.4	24.8	-4.2	2.3	2.9	-2.5	0.4	0.9	2.1	2.3	-5.0	3.2	-4.0	-3.8
Number of operations (self-reported)	0.3	0.5	1.7	-0.2	-0.4	-1.0	0.7	0.5	0.7	-0.3	-1.3	1.1	0.3	0.0	0.4
Average weekly beer plus cider intake	2.9	4.2	8.4	2.2	-1.1	-1.8	-2.9	-2.8	-1.0	-1.8	-1.6	-2.1	-2.1	2.5	1.9
Irritability	0.5	0.8	2.3	0.6	-0.4	0.2	0.1	-0.3	-0.6	0.2	-0.1	1.3	-1.5	1.5	1.5
Risk taking	2.0	2.9	6.1	-1.1	1.1	1.6	2.5	2.5	2.1	2.2	1.5	1.3	1.5	-0.7	-1.0
Ever had prostate specific antigen (PSA) test	2.1	2.4	9.2	0.6	1.6	-0.0	2.2	1.7	3.0	1.2	1.3	1.7	1.3	0.4	0.7
Fractured/broken bones in last 5 years	0.1	0.2	0.4	-0.5	0.6	-0.2	-0.0	0.1	0.4	-0.6	-0.6	-0.4	0.5	-0.4	0.3
Age started oral contraceptive pill	0.9	1.2	3.3	-1.0	0.3	0.7	0.5	1.1	1.1	1.2	0.7	-0.1	1.2	-1.8	-1.8
Diastolic blood pressure, automated reading	1.0	3.1	5.9	1.7	-1.0	-1.7	-0.9	-1.9	-2.3	-2.1	-2.0	0.9	-2.0	1.4	2.4
Ever depressed for a whole week	0.9	1.1	3.0	0.1	1.7	1.0	0.8	1.1	1.7	1.1	1.5	-0.2	0.6	-0.2	0.7
Unable to work because of sickness or disability	2.6	3.4	10.4	1.2	-1.5	-3.2	-1.3	-1.7	-1.6	-2.0	-2.6	0.1	-1.7	2.0	1.4
Commuting to job workplace: Cycle	3.0	3.6	7.2	-1.5	0.2	1.9	1.7	2.5	2.1	2.7	2.7	0.7	2.3	-1.4	-1.4
Myopia	0.3	0.4	2.0	0.4	1.4	-0.3	0.1	-0.3	0.8	-0.3	-0.7	-0.2	0.4	0.1	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.5	-0.2	0.7	0.3	1.8	1.4	2.4	1.1	1.8	1.5	0.9	-0.2	0.3
Cholesterol lowering medication	1.7	2.4	4.4	1.6	-0.2	-1.7	-1.9	-1.6	-1.6	-1.7	-1.9	-1.1	-2.1	1.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.8	1.7	0.2	-0.9	-0.3	-0.2	-0.1	-1.1	-0.8	-0.2	-1.1	0.6	1.2
Pain experienced in last month	0.8	1.3	3.8	1.6	-1.5	-0.9	1.4	-0.0	-1.1	-0.1	-0.6	1.9	-1.6	0.5	-0.6
Supplements: Calcium	0.6	0.7	1.9	0.3	-0.9	-0.9	1.0	0.8	1.0	-0.1	-1.4	0.9	0.3	0.6	-0.7
Basal cell carcinoma (self-reported)	0.9	1.1	3.6	-0.7	0.2	-0.1	1.9	1.5	1.1	0.5	0.8	1.7	1.1	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	2.4	3.0	8.6	1.2	-0.5	-0.7	-2.9	-2.4	-2.4	-1.3	-1.5	-2.1	-1.4	1.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	-0.2	-0.2	-0.7	-0.8	-0.5	-0.6	0.2	0.2	-0.8	-0.3	-0.0	0.4
Heart disease (siblings)	1.2	1.5	6.3	-0.3	0.1	0.6	-2.2	-1.6	-1.5	0.0	-0.1	-2.5	-0.7	0.0	-0.8
Alcohol drinker status: Previous	1.3	1.5	4.0	0.7	-1.7	-0.4	-0.7	-0.8	-1.9	-1.2	-2.0	0.7	-1.4	0.9	1.1
Pack years of smoking	0.5	0.8	1.3	1.0	0.4	-1.0	-0.7	-1.1	-0.8	-1.1	-0.4	-0.0	-1.1	1.0	1.0
Impedance of whole body	0.1	0.7	2.9	0.0	-0.2	0.7	1.0	1.4	1.7	0.9	0.3	-0.4	0.1	0.1	-1.2
Leg fat mass (left)	1.1	4.3	18.5	-0.8	0.1	0.2	-4.3	-2.9	-2.6	-1.5	-1.4	-3.4	-0.9	-0.6	-0.4
Arm predicted mass (left)	1.7	8.7	24.8	-3.9	2.0	2.8	-2.6	0.3	0.7	1.9	2.0	-5.0	3.0	-3.8	-3.8