Best TWAS P=3.17e-16 · Best GWAS P=9.28e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | -8.3 | -8.2 | 3.2e-16 | 0.97 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | HACE1 | 0.20 | 0.13 | lasso | 3 | 0.14 | 6.2e-05 | -4.8 | -6.5 | 5.8e-11 | 0.49 | 0.51 | 0.04 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | HACE1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | -4.9 | 6.2 | 4.2e-10 | -0.59 | 0.10 | 0.40 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HACE1 | 0.05 | 0.01 | blup | 72 | 0.02 | 1.6e-03 | -4.8 | 6.5 | 1.1e-10 | -0.55 | 0.50 | 0.32 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HACE1 | 0.08 | 0.04 | blup | 72 | 0.05 | 1.1e-06 | -4.9 | 5.7 | 1.1e-08 | -0.50 | 0.84 | 0.06 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HACE1 | 0.17 | 0.03 | enet | 21 | 0.11 | 3.2e-05 | -6.5 | 6.9 | 5.4e-12 | -0.50 | 0.03 | 0.69 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | HACE1 | 0.09 | 0.03 | enet | 18 | 0.06 | 1.9e-06 | -4.8 | 5.4 | 7.8e-08 | -0.46 | 0.76 | 0.05 | FALSE |