Hub : Genes

MVK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.110	0.0430	5.6e-03	0.084	NA	0.062	NA	0.056	7.1e-07	NA	2.1e-05	NA	5.3e-05
2	GTEx	Skin Sun Exposed Lower leg	0.124	0.0440	6.4e-04	0.052	NA	0.065	NA	0.062	3.9e-05	NA	4.6e-06	NA	7.4e-06
3	GTEx	Whole Blood	0.054	0.0270	7.5e-03	0.001	NA	-0.001	NA	-0.002	2.7e-01	NA	4.8e-01	NA	6.2e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.250	0.0722	3.0e-10	0.137	0.113	0.113	NA	0.128	3.2e-15	1.1e-12	1.1e-12	NA	2.9e-14
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.056	0.0330	7.2e-03	0.024	0.031	0.061	NA	0.024	1.5e-02	7.0e-03	2.1e-04	NA	1.6e-02
6	TCGA	Thyroid Carcinoma	0.094	0.0420	7.2e-04	-0.002	0.025	0.033	NA	0.006	6.2e-01	1.5e-03	3.5e-04	NA	8.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.5	2.4	6.3	0.5	2.1	1.4	-2.5	0.3	1.3
Bipolar Disorder or Schizophrenia	1.6	3.8	13.7	0.6	0.7	3.7	-0.3	2.8	0.3
Depressed Affect (Nagel 2018)	2.9	6.1	20.0	-1.4	1.0	-3.5	-1.1	-4.5	0.4
Depression (Nagel 2018)	1.0	1.5	3.5	-1.3	0.3	-1.4	-0.5	-1.9	1.3
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.4	0.2	-1.1	-2.0	2.1	-0.1	-1.8
Neuroticism (Nagel 2018)	5.7	13.4	39.2	-2.0	0.0	-5.6	-1.7	-6.3	1.8
Schizophrenia (2018)	2.3	4.8	12.9	0.5	-0.8	3.6	1.7	3.4	-0.7
Schizophrenia vs Biploar Disorder	1.9	2.5	5.6	-0.4	-1.4	2.4	1.6	2.2	-0.0
Worry (Nagel 2018)	3.9	8.2	25.0	-1.7	-0.7	-4.1	-1.5	-5.0	1.4
Alzheimer’s Disease (in mother)	1.9	2.3	7.2	0.3	1.4	-0.8	-2.7	-1.6	1.0
Alzheimer’s Disease (in father)	1.4	1.6	3.3	1.8	-1.5	1.5	0.8	1.0	0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	3.5	1.6	0.7	-0.5	-1.9	-1.4	0.9
Crohns Disease (2017)	0.4	0.9	2.5	-0.2	-1.1	-1.0	0.2	-1.6	-0.8
Irritable Bowel Disease (IBD)	0.5	1.2	2.8	-1.1	-1.6	0.1	1.7	-0.4	-0.7
Ulcerative Colitis (UC)	0.7	1.4	3.7	-1.9	-0.7	1.0	1.6	0.6	-0.6
Major Depression (MDD)	1.2	1.4	3.7	0.3	-0.6	-1.9	0.1	-1.9	-1.0
Reaction Time	0.2	0.4	0.8	0.9	0.2	0.8	-0.1	0.9	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.9	-0.8	-0.9	-1.6	1.0	-0.8	-1.7
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	2.9	3.9	6.5	0.3	-2.5	-2.4	1.1	-2.5	-1.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.8	1.8	0.3	0.8	1.3	-0.8	1.0	0.7
Bipolar Disorder (2011)	1.8	1.7	4.2	0.3	1.7	2.1	-1.5	0.9	0.6
Body Mass Index (BMI) (2010)	1.4	1.9	5.1	0.4	-1.6	-0.5	1.8	-0.5	-2.2
Coronary Artery Disease (CAD)	1.3	1.5	3.4	0.6	1.9	0.6	-1.7	-0.5	1.3
Crohns Disease (2012)	0.2	0.4	0.7	0.7	0.1	-0.7	-0.4	-0.9	0.4
Mean Putamen Volume	0.4	0.4	2.1	1.4	0.0	0.5	-0.2	0.2	0.5
Fasting Glucose	1.7	2.0	6.5	-0.6	-1.3	-0.9	1.1	-1.3	-2.6
HbA1C	0.9	1.0	3.8	-1.9	-0.3	-0.8	-0.2	-1.1	0.3
HDL Cholesterol	8.6	14.4	45.4	-0.7	-1.9	-6.0	0.7	-6.7	0.8
LDL Cholesterol	0.1	0.2	0.4	0.5	-0.1	-0.6	0.6	-0.5	-0.4
Lupus	0.3	0.5	1.1	-0.8	-0.0	0.6	-1.0	-0.5	0.8
Neuroticism (2016)	1.5	2.1	4.6	-1.6	1.0	-2.2	-1.4	-1.4	0.7
Primary Biliary Cirrhosis	1.7	2.5	4.6	1.4	-1.7	0.7	2.1	0.6	-2.1
Rheumatoid Arthritis	1.0	1.4	5.0	1.1	-0.5	-0.8	1.2	0.1	-2.2
Schizophrenia (2014)	1.9	4.2	14.5	1.3	0.1	3.8	0.3	3.0	-0.3
Triglycerides	0.2	0.3	1.0	1.0	0.4	-0.2	-0.4	-0.2	-0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.7	-0.8	0.2	0.4	-0.1	0.4	-1.6
Ulcerative Colitis	0.8	1.1	2.4	-1.6	-0.9	0.9	1.5	0.5	-0.3
Blood Eosinophil Count	1.4	10.5	24.6	-2.0	-5.0	-3.8	3.0	-2.8	-1.8
Blood Platelet Count	1.2	13.5	46.2	-6.8	-2.6	0.3	0.5	2.8	-4.4
Blood Red Count	0.2	1.6	4.5	-0.7	0.1	-2.0	-2.1	0.4	0.8
Blood White Count	1.8	13.3	41.0	-1.1	-6.4	-3.1	3.6	-1.7	-3.5
Heel T-Score	0.1	1.1	4.7	0.6	0.5	-0.0	-1.1	0.2	2.2
BMI	2.4	14.2	23.8	4.8	-2.3	-4.9	1.0	-4.8	-3.0
Height	0.3	5.5	14.2	3.8	1.4	-0.6	0.2	-2.9	2.9
Waist Hip Ratio (WHR)	0.2	0.9	2.5	0.4	-0.6	1.2	-0.5	0.7	1.6
Systolic Blood Pressure	1.8	9.2	19.4	-0.6	-2.5	2.0	4.4	4.4	-2.5
Smoking Status	0.5	1.2	3.3	-0.9	-0.4	-1.8	0.5	-1.5	-0.7
Allergy or Eczema	1.3	3.5	10.7	0.6	0.7	-2.3	-1.3	-3.3	1.4
Cardiovascular Disease	1.5	4.8	10.9	1.6	-2.9	-0.3	3.3	0.5	-2.6
Hypothyroidism (self reported)	0.8	1.8	3.8	-0.1	-1.4	-1.7	0.1	-1.9	-1.5
Respiratory disease	0.2	0.5	1.6	-0.6	1.3	0.2	-0.6	-0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.8	1.2	-0.5	-0.1	0.2	-1.3	0.4
Lung FEV1/FVC ratio	1.4	7.0	18.7	-1.7	-4.3	-3.0	2.6	-0.6	-2.0
Lung FVC	1.7	8.5	26.8	-1.0	3.1	0.9	-3.5	0.5	5.2
Neuroticism	4.7	11.4	37.2	-0.8	-0.2	-5.3	-1.4	-6.1	0.4
Chronotype (morning person)	1.5	3.5	9.7	0.5	0.5	-3.1	-2.2	-2.4	0.3
Hair Pigment	0.0	1.4	6.4	-2.5	-0.1	0.6	-0.5	1.0	0.6
Tanning	0.1	1.1	3.1	1.0	-0.6	-0.8	1.8	0.0	1.3
Hand grip strength (left)	0.3	0.8	2.7	0.2	0.3	1.6	0.7	1.1	0.7
Number of treatments/medications taken	1.2	2.2	4.2	2.0	-1.5	-1.1	0.8	-1.8	-1.2
Average weekly spirits intake	0.3	0.4	1.9	-0.1	0.4	-0.6	-0.1	-1.4	-0.0
Sensitivity / hurt feelings	5.2	8.8	26.6	-0.9	-1.9	-5.2	-0.8	-4.5	0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.6	-0.6	1.0	-1.0	-0.9	-1.6	0.8
Hearing difficulty/problems: Yes	4.7	7.1	22.2	0.1	-0.2	-4.1	-1.4	-4.7	1.2
Relative age of first facial hair	0.4	0.8	2.5	0.6	0.6	-0.6	-0.3	-1.6	1.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.3	1.8	0.2	-0.5	-0.3	-1.5	0.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.4	-1.0	-2.3	-0.2	1.1	0.1	-0.8
Ever had hysterectomy (womb removed)	0.2	0.3	1.1	1.0	0.5	-0.3	0.3	-0.2	-0.1
Systolic blood pressure, automated reading	2.1	6.0	15.4	0.5	-2.2	1.2	3.9	2.9	-2.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.7	-0.3	-1.6	-1.4	0.9	-0.1	-1.6
Angina	1.5	2.0	4.9	1.5	-0.9	-2.0	-0.1	-2.2	-0.3
Medication for hormone replacement therapy	1.9	2.1	5.8	-0.5	-1.5	-1.4	0.4	-2.4	-1.5
Vitamin and mineral supplements	1.0	1.3	3.2	-1.2	-0.5	1.4	0.8	1.8	0.1
Supplements: Zinc	1.4	1.6	7.3	0.1	-1.3	-0.5	2.7	-0.1	-0.2
Medication: Co-codamol	1.5	1.7	3.4	0.9	-1.3	-1.7	1.0	-1.8	-0.5
Medication: Metformin	1.4	1.9	4.2	1.6	-2.0	-1.1	1.2	-1.3	0.5
Diabetes (father)	1.2	1.4	4.0	-2.0	-0.9	-1.1	1.5	-0.1	0.5
Diabetes (mother)	0.4	0.5	1.4	-0.7	1.2	0.6	-0.8	-0.1	0.5
Severe depression (siblings)	1.3	1.4	4.6	0.3	0.8	-0.9	-2.2	-0.8	1.2
Pack years adult smoking proportion	1.1	1.6	6.8	-0.0	0.1	-1.5	-0.7	-2.6	-0.5
Impedance of leg (right)	2.1	10.3	28.3	-4.2	0.0	3.5	1.4	5.3	-1.2
Leg fat-free mass (left)	1.8	9.6	25.7	4.2	-0.4	-3.7	0.1	-5.1	0.6
Trunk fat percentage	0.8	3.3	6.1	2.4	-1.4	-2.5	1.4	-1.0	-1.8
Hand grip strength (right)	0.5	1.2	4.2	1.3	0.1	0.7	0.9	-0.4	2.0
Townsend deprivation index at recruitment	2.0	2.8	7.3	1.6	-0.2	-2.4	-0.9	-2.7	0.1
Current tobacco smoking	1.2	2.0	4.2	-2.1	0.7	-1.7	-1.0	-1.5	-0.9
Average weekly fortified wine intake	0.9	1.1	3.1	0.6	0.9	1.3	-0.5	1.8	0.2
Maternal smoking around birth	1.9	2.7	7.6	1.1	-0.7	-2.8	0.4	-2.5	0.9
Fed-up feelings	1.3	2.4	5.8	-1.3	0.3	-2.4	-0.8	-2.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	-1.8	0.1	-1.0	-0.5	-0.9	-0.2
Relative age voice broke	1.4	2.2	4.2	0.5	2.1	-0.5	-1.9	-1.4	1.6
Taking other prescription medications	0.7	1.0	2.2	1.4	-1.5	0.5	0.7	-1.0	-0.5
Age when periods started (menarche)	0.9	2.2	4.9	-1.7	-0.7	-2.1	-0.6	-2.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.1	-0.3	0.4	-0.1	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	6.6	-1.7	-1.9	1.1	2.5	2.6	-1.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	0.6	0.7	0.7	0.5	0.1	1.2
Qualifications: CSEs or equivalent	1.4	1.9	3.9	0.2	1.4	-1.5	-1.8	-2.0	0.2
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.2	-1.4	-0.9	1.1	-0.5	0.3
High blood pressure	0.9	2.4	4.9	1.7	-0.3	1.7	1.8	2.2	-0.7
Hayfever, allergic rhinitis or eczema	1.2	2.5	7.4	0.1	0.6	-2.1	-1.6	-2.7	0.5
Multivitamins +/- minerals	0.4	0.5	1.1	0.9	1.1	-0.7	-0.6	-0.5	-0.4
Stomach or abdominal pain in last month	0.5	0.7	1.7	-0.2	-1.0	-0.6	-0.4	-0.9	-1.3
Supplements: Glucosamine	1.1	1.5	4.7	-2.2	0.8	0.7	-0.2	1.7	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	-0.2	0.7	1.1	-0.3	0.6	-0.2
Medication: Atenolol	1.8	2.2	10.5	0.9	-3.2	-0.2	1.4	0.2	-0.3
Medication: Levothyroxine sodium	0.8	1.4	3.5	0.5	-1.6	-1.0	-0.2	-1.9	-1.0
Sitting height	0.3	2.2	3.9	1.8	2.0	1.4	-0.7	-0.5	1.8
Chronic bronchitis/emphysema (father)	2.1	2.5	5.2	0.7	-2.3	-1.7	0.9	-2.2	-0.6
High blood pressure (mother)	2.4	3.3	12.4	0.2	-2.5	-0.0	3.5	0.5	-0.8
Body mass index (BMI)	1.5	6.4	11.8	3.2	-1.5	-3.4	0.6	-3.4	-1.5
Impedance of leg (left)	2.1	10.4	31.0	-4.0	0.3	3.6	1.2	5.6	-1.2
Leg predicted mass (left)	1.8	9.5	25.4	4.2	-0.5	-3.6	0.2	-5.0	0.4
Trunk fat mass	1.1	4.5	9.9	3.1	-1.1	-2.9	1.1	-2.1	-1.4
Waist circumference	1.2	4.3	10.9	3.3	-0.7	-2.5	0.2	-2.7	-1.0
Number of incorrect matches in round	2.4	3.9	11.1	3.3	1.6	1.7	-1.8	1.8	0.8
Past tobacco smoking	0.2	0.4	0.9	0.0	0.5	1.0	-0.5	1.0	-0.1
Alcohol usually taken with meals	0.3	0.5	1.7	1.3	-0.4	0.2	0.1	0.4	1.0
Nervous feelings	2.1	4.0	8.8	-1.3	-2.2	-3.0	-0.2	-2.9	-0.6
Frequency of tenseness / restlessness in last 2 weeks	4.2	6.6	19.0	-0.9	0.8	-4.0	-1.4	-4.4	-0.8
Hearing difficulty/problems with background noise	3.3	5.3	16.2	-0.6	0.1	-4.0	-1.2	-3.7	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	2.5	0.3	-0.2	1.0	-0.1	1.6	-0.2
Had menopause	0.7	0.9	3.1	0.2	-0.4	1.0	0.7	1.7	-0.7
Had other major operations	0.3	0.3	0.8	0.4	-0.4	-0.7	0.2	-0.9	-0.6
Forced vital capacity (FVC)	0.4	1.5	8.2	0.1	0.5	0.1	-0.4	-0.7	2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	6.2	-1.0	-0.7	1.0	1.6	2.5	-1.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.8	0.6	-0.4	-1.3	-0.8	-2.4	0.5
Qualifications: None of the above	0.6	1.3	3.1	0.2	1.3	1.8	-1.1	0.2	1.4
Financial difficulties in last 2 years	1.4	1.9	6.9	0.2	0.9	-1.8	-0.3	-2.6	0.5
Mouth/teeth dental problems	5.4	8.3	23.2	1.4	2.4	4.8	-1.1	4.2	0.2
Heart attack	0.3	0.4	1.2	0.3	-0.9	0.3	0.5	0.5	-1.1
Allergy	1.5	3.5	10.7	1.1	-0.6	2.6	1.3	3.3	0.4
Pain all over the body in last month	2.4	2.6	6.8	0.3	-0.5	-2.4	0.7	-2.6	-1.4
Diabetes (self-reported)	0.3	0.4	0.7	0.8	-0.8	0.7	0.2	-0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.6	1.2	-0.9	-0.6	0.1	-1.6	0.0
Medication: Ramipril	2.0	2.6	4.9	1.2	-0.5	1.2	1.6	2.2	-2.2
Medication: Simvastatin	1.0	1.5	3.1	0.6	-1.8	-0.9	1.3	-1.2	-1.3
Fluid intelligence score	0.9	1.9	4.5	-1.5	-0.7	-1.7	1.1	-0.1	-2.1
Illnesses of siblings	0.6	0.9	4.5	2.1	0.1	0.7	-0.5	0.1	0.2
Neuroticism score	3.5	7.4	21.1	-1.6	-1.0	-4.4	-0.5	-4.6	0.2
Weight	1.6	7.9	18.1	4.3	-0.9	-3.5	0.8	-4.0	-0.6
Impedance of arm (right)	0.4	2.0	6.0	-2.5	-0.1	0.4	0.8	2.3	-0.2
Arm fat percentage (right)	1.1	4.4	11.0	2.2	-1.4	-3.3	0.8	-2.4	-1.4
Trunk fat-free mass	1.0	5.7	15.0	3.9	0.5	-1.8	-0.2	-3.8	1.2
Hip circumference	1.3	5.8	12.0	2.4	-1.1	-3.5	1.2	-3.2	-2.0
Time employed in main current job	0.4	0.4	1.0	0.1	0.8	0.7	-1.0	0.5	-0.2
Alcohol intake versus 10 years previously	0.8	1.3	3.8	1.6	-0.1	-0.2	-0.1	-1.0	1.9
Father’s age at death	1.2	1.6	5.1	-2.3	0.2	-0.1	-1.0	0.3	1.9
Worrier / anxious feelings	3.4	6.5	18.5	-1.4	-1.4	-4.3	0.3	-3.9	1.3
Frequency of tiredness / lethargy in last 2 weeks	5.4	8.7	28.6	-1.3	-0.9	-4.3	-1.7	-5.3	-0.2
Falls in the last year	3.5	4.8	12.8	1.1	-1.6	-3.2	1.3	-3.6	-0.5
Hair/balding pattern: Pattern 3	1.6	2.4	3.8	1.8	1.4	-1.2	-2.0	-1.6	1.0
Number of live births	1.2	1.7	5.2	1.2	-1.1	-1.0	0.6	-1.0	-2.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	6.7	-0.3	-0.4	-0.2	-0.1	0.1	2.6
Pulse rate	0.9	1.6	4.1	0.3	-1.3	-2.0	0.1	-1.7	-0.8
Happiness	1.2	1.5	2.6	-0.0	1.3	-1.2	-1.3	-1.3	1.6
Noisy workplace	1.4	1.8	4.8	2.2	0.5	-1.0	-0.2	-2.1	0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.3	-0.0	-0.5	0.4	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	4.0	4.6	14.7	1.5	3.8	1.3	-2.8	-0.6	0.8
Mouth/teeth dental problems: Dentures	2.3	4.0	8.7	-1.8	-2.3	-2.9	1.2	-1.7	-1.4
Asthma	0.6	1.1	4.3	-2.1	1.0	-0.3	-0.7	-0.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.0	1.1	1.3	-0.2	-1.4	-2.0	0.9
Medication: Cholesterol lowering	1.3	2.1	5.5	1.5	-1.0	-1.3	0.9	-2.3	-1.1
Depression (self-reported)	0.7	0.8	3.1	-0.1	0.6	0.2	-1.8	-1.0	-0.7
Medication: Lansoprazole	0.2	0.3	0.7	0.2	-0.6	0.2	0.8	0.1	0.6
Prospective memory result	0.9	1.2	2.9	1.5	0.7	1.7	-1.0	-0.4	0.5
Lung cancer (father)	1.0	1.2	3.1	-1.0	-0.3	-1.4	0.7	-1.8	0.7
Illnesses of mother	2.6	3.2	9.0	0.2	2.2	1.3	-3.0	0.5	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.8	-0.0	-0.1	-0.5	0.1	-0.4	2.2
Pulse wave Arterial Stiffness index	1.6	1.8	5.7	-0.5	-1.2	-2.4	1.1	-1.2	-0.9
Impedance of arm (left)	0.3	1.6	5.4	-1.8	0.3	0.7	0.6	2.3	0.0
Arm fat mass (right)	1.4	5.9	12.2	3.0	-1.5	-3.5	1.0	-3.2	-0.9
Trunk predicted mass	0.9	5.4	13.9	3.7	0.6	-1.7	-0.3	-3.7	1.3
Standing height	0.2	2.5	7.8	2.8	1.2	-0.3	0.5	-1.7	1.5
Length of working week for main job	1.0	1.1	4.6	0.4	-0.4	-2.1	-0.7	-1.1	0.0
Exposure to tobacco smoke at home	0.8	0.9	2.3	1.2	0.6	-0.7	-0.7	-1.5	-0.4
Breastfed as a baby	0.9	1.1	2.6	0.4	0.1	1.6	1.0	1.6	0.6
Tense / ‘highly strung’	0.3	0.4	1.1	-0.4	0.9	0.1	-1.0	-0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.3	0.5	1.5	-0.6	-1.9	-2.3	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.3	-0.9	-0.5	1.1	-0.3	-0.5
Birth weight of first child	3.8	6.9	14.7	2.6	1.3	-1.7	-2.2	-3.2	3.8
Peak expiratory flow (PEF)	1.3	2.9	9.3	0.4	1.5	1.6	-1.3	3.1	1.1
Pulse wave reflection index	0.4	0.5	1.1	-0.7	-0.1	-1.1	0.6	-0.5	0.7
Ever highly irritable/argumentative for 2 days	1.4	1.6	6.3	-0.4	-0.9	-2.5	0.9	-1.1	-0.7
Loud music exposure frequency	1.0	1.1	2.4	0.4	1.0	-1.3	-1.1	-1.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.0	-0.1	-0.0	-1.0	-0.1	-0.3	0.4
Mouth/teeth dental problems: Bleeding gums	4.5	5.9	15.2	-1.2	-1.4	-3.9	0.0	-3.8	1.5
Blood clot in the leg (DVT)	0.4	0.5	1.5	-0.0	-0.4	-1.2	0.2	-1.2	0.1
Medication: Paracetamol	2.5	4.1	15.1	-0.3	-0.5	-2.7	-1.3	-3.9	-0.5
Headache pain in last month	2.4	4.2	9.1	0.4	-2.1	-2.5	-0.0	-3.0	-2.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	6.6	-2.6	0.9	-0.6	-1.3	0.4	0.5
Glaucoma (self-reported)	0.2	0.3	1.1	1.1	0.1	-0.3	0.3	-0.4	-0.3
Gout (self-reported)	1.7	2.3	5.5	1.3	1.3	2.4	-0.8	2.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.2	-0.4	-0.9	-1.3	-0.2	-2.1	-0.9
Medication: Amlodipine	0.8	1.1	3.6	0.2	0.6	1.9	0.1	1.6	0.1
Medication: Ventolin 100micrograms inhaler	1.6	2.0	5.6	-1.0	-0.7	-2.0	-0.1	-2.4	0.9
Birth weight	0.4	0.9	2.6	1.6	1.1	-0.5	-1.2	-0.0	0.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.2	-0.9	-1.2	-1.5	1.0	-0.7	-0.1
High blood pressure (siblings)	0.4	0.6	1.6	-0.7	-0.2	0.8	0.2	1.3	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	7.1	0.1	1.0	-0.5	-0.7	-1.3	2.7
Body fat percentage	0.8	3.3	6.4	2.3	-1.3	-2.5	1.3	-1.2	-1.8
Leg fat percentage (right)	0.8	3.0	5.3	1.5	-1.7	-2.3	1.6	-0.9	-2.0
Arm fat-free mass (right)	0.8	4.3	11.8	3.4	0.4	-1.6	-0.4	-3.2	1.0
Exposure to tobacco smoke outside home	1.8	2.4	6.3	-0.4	-0.6	-2.5	1.0	-1.8	-1.8
Comparative body size at age 10	0.7	1.9	3.6	-0.4	-1.9	-1.8	1.4	-1.4	-0.5
Number of full brothers	0.5	0.6	1.5	-0.2	-0.7	-1.2	0.4	-1.2	-0.5
Worry too long after embarrassment	3.4	5.8	18.0	-1.7	-1.5	-4.2	-0.3	-3.2	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	6.7	1.0	2.3	-0.8	-2.6	-0.8	1.4
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.8	0.5	-1.0	-0.6	-0.9	-0.0
Number of children fathered	0.4	0.4	1.7	-1.3	-0.4	-0.0	-0.3	-0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	5.0	1.4	-1.9	0.6	1.7	1.4	-2.2
Age at first live birth	0.4	0.8	1.5	-1.2	-0.0	1.0	0.6	1.2	0.7
Pulse wave peak to peak time	1.4	1.6	5.1	0.7	1.1	2.3	-0.9	1.0	0.9
Health satisfaction	1.0	1.3	3.7	0.7	-1.4	-1.4	0.4	-1.9	0.1
Shortness of breath walking on level ground	0.8	0.9	2.7	0.7	-0.3	-1.6	0.1	-1.1	-1.0
Qualifications: College or University degree	0.3	1.0	2.8	0.3	0.4	-0.8	-1.1	-1.7	0.9
Eye problems/disorders: None of the above	0.8	0.9	3.6	-0.6	1.9	0.8	-0.8	0.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	-0.2	-0.5	-0.9	1.4	-0.3	-0.8
Emphysema/chronic bronchitis	0.5	0.5	1.1	0.8	0.7	-1.0	-0.7	-0.8	0.0
Medication for pain relief, constipation, heartburn	0.5	0.9	3.7	-0.9	-0.0	0.1	0.7	1.9	0.4
Neck or shoulder pain in last month	2.1	3.0	7.1	-1.5	0.7	-2.4	-1.4	-2.7	0.5
Medication: Blood pressure	1.5	2.6	6.9	2.6	-0.6	1.9	1.7	1.2	0.5
Angina (self-reported)	1.6	2.1	4.7	1.3	-1.3	-2.1	0.2	-2.2	-0.8
Migraine (self-reported)	0.5	0.6	2.5	-0.8	-1.6	0.0	0.3	-0.6	0.4
Medication: Ibuprofen	0.6	0.7	3.2	0.1	0.5	-0.8	-0.6	-1.8	-0.1
Medication: Allopurinol	1.3	1.7	5.0	0.4	0.7	2.2	0.5	1.8	0.9
Medication: Omeprazole	0.2	0.2	0.7	0.8	-0.6	0.2	-0.2	0.4	-0.0
Medication: Seretide 50 evohaler	0.4	0.4	1.3	1.1	0.9	-0.1	-0.1	0.1	-0.6
Mean time to correctly identify matches	0.4	0.8	1.3	0.9	1.1	0.7	-0.8	0.8	0.8
Heart disease (mother)	0.5	0.6	1.3	1.0	-0.0	-1.1	1.1	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-1.2	0.9	0.1	0.8	0.7	1.0
Whole body fat mass	1.3	5.2	11.6	3.4	-1.1	-3.1	0.9	-2.7	-1.2
Leg fat mass (right)	1.3	4.9	9.4	2.9	-1.3	-3.1	1.3	-2.6	-1.4
Arm predicted mass (right)	0.9	4.6	12.6	3.5	0.3	-1.8	-0.2	-3.3	0.8
Pulse rate, automated reading	1.0	3.4	10.9	0.5	-0.9	-3.3	-0.8	-2.6	-0.8
Alcohol intake frequency.	0.8	1.8	7.8	2.8	-1.0	-0.8	0.1	-0.6	-1.0
Comparative height size at age 10	0.6	3.6	10.6	2.0	1.6	3.2	0.6	1.7	1.0
Number of full sisters	0.4	0.4	1.3	-1.1	-0.6	-0.3	-0.2	-0.8	0.4
Suffer from ‘nerves’	1.4	2.2	6.3	-1.2	-0.3	-2.1	-0.8	-2.5	0.5
Overall health rating	0.9	1.9	4.0	0.2	-2.0	-1.7	0.6	-1.6	-1.3
Chest pain or discomfort	0.7	1.0	2.6	0.6	-0.6	-1.6	0.2	-1.6	0.0
Had major operations	0.7	0.9	2.1	0.6	-0.8	-0.9	1.5	-0.8	-0.8
Age at last live birth	0.2	0.4	1.3	-1.2	0.3	0.4	0.5	0.3	-0.5
Family relationship satisfaction	0.4	0.5	2.3	-0.4	1.5	-0.4	-0.6	-0.1	0.2
Leg pain on walking	0.1	0.1	0.4	0.5	-0.1	0.6	-0.0	-0.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	1.2	-0.5	-1.0	-0.1	-0.4	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.8	0.6	0.5	-0.1	0.7	0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.7	-0.3	-1.6	0.4	1.1	1.4	0.3
Medication: Aspirin	1.0	1.3	4.2	2.0	-0.8	-0.3	0.5	-1.2	-1.3
Supplements: Vitamin C	0.5	0.6	1.4	0.6	-0.1	-0.7	-0.5	-1.2	-0.9
Knee pain experienced in last month	0.9	1.4	4.4	0.8	-0.3	-1.8	0.5	-2.1	0.4
Hypertension (Self-reported)	1.1	3.1	4.8	1.8	-0.9	1.8	2.2	2.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	5.6	0.6	0.9	2.4	-1.8	0.9	0.9
Illnesses of father: Heart disease	0.6	0.8	2.8	0.1	-0.3	-1.7	-0.8	-0.9	-0.6
Illnesses of siblings: Diabetes	1.0	1.2	6.8	-2.6	-0.1	0.1	-0.1	0.7	-0.4
Smoking status: Previous	0.3	0.4	1.2	0.8	-0.3	-0.5	1.1	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.1	-0.4	0.1	-0.3	0.4	-1.8	0.6
Whole body fat-free mass	1.3	7.4	19.6	4.1	0.2	-2.6	-0.2	-4.4	1.0
Leg fat-free mass (right)	1.7	9.1	24.2	4.2	-0.1	-3.4	-0.2	-4.9	0.7
Arm fat percentage (left)	0.9	3.7	9.6	2.2	-1.1	-3.1	0.5	-2.2	-1.2
Average weekly red wine intake	0.3	0.5	1.3	-0.7	-0.8	0.3	1.1	0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	1.1	1.1	0.9	-0.7	0.9	0.2
Mood swings	1.8	3.2	11.9	-0.1	0.7	-2.6	-0.6	-3.5	-0.1
Loneliness, isolation	0.8	1.2	2.8	-1.4	1.7	-0.8	-1.2	-0.5	0.1
Long-standing illness, disability or infirmity	2.3	3.4	9.8	2.3	-1.1	-2.0	0.4	-3.1	0.5
Ever had bowel cancer screening	3.3	3.9	13.4	1.1	2.3	0.9	-1.3	-0.9	3.7
Diabetes diagnosed by doctor	0.2	0.4	0.9	0.6	-0.9	0.5	0.7	-0.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	0.6	-0.9	-0.1	0.2	-0.7	-0.9
Friendships satisfaction	0.6	0.8	1.8	1.3	1.4	-1.0	0.0	-0.3	0.3
Qualifications: nursing, teaching	1.9	2.9	8.2	-0.1	-1.1	-1.5	2.3	0.7	-2.9
Commuting to job workplace: Walk	0.9	1.0	3.3	1.2	-0.5	-0.9	-0.0	-1.8	-0.0
Eye problems/disorders: Cataract	0.5	0.6	1.5	-0.0	-1.1	-1.2	0.3	-0.8	0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	5.3	-0.1	-1.0	-2.3	0.6	-1.9	-0.6
Medication for cholesterol	3.3	5.0	12.1	1.2	3.0	1.9	-1.9	0.8	3.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	1.3	-0.1	-1.0	-0.7	-1.0	0.4
Back pain experienced in last month	1.5	2.2	6.2	-1.0	-0.8	-2.5	-0.5	-2.3	-0.2
Mineral and other dietary supplements	0.9	1.2	2.0	1.2	-1.4	0.4	1.2	-0.5	-1.4
Breast cancer (self-reported)	0.2	0.3	0.6	0.5	0.8	0.5	-0.1	-0.2	0.7
Asthma (self-reported)	0.5	1.0	3.1	-1.8	1.2	-0.2	-0.8	-0.2	-1.0
Osteoporosis (self-reported)	0.3	0.3	1.0	-0.1	-1.0	0.2	-0.4	0.6	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.7	-0.5	-0.9	-0.5	1.3	0.1	-0.3
Medication: Aspirin	1.1	1.4	4.0	2.0	-0.4	-0.4	0.5	-1.3	-1.4
Medication: Gliclazide	0.7	0.8	1.6	1.2	-1.2	-0.1	0.5	-0.9	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	-0.0	0.9	0.4	0.1	0.6	-0.2
Smoking status: Current	1.3	2.0	4.8	-2.2	1.1	-1.1	-1.5	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.5	-0.4	-1.0	-0.3	0.5	1.1	1.9
Whole body water mass	1.3	7.1	19.1	4.0	0.2	-2.6	-0.1	-4.4	1.1
Leg predicted mass (right)	1.7	9.0	24.5	4.2	-0.1	-3.4	-0.3	-4.9	0.7
Arm fat mass (left)	1.2	5.1	10.3	3.0	-1.1	-3.2	0.6	-3.0	-0.8
Number of self-reported non-cancer illnesses	0.4	0.8	1.9	1.4	-0.4	0.1	-0.3	-1.1	-1.0
Average weekly champagne plus white wine intake	0.3	0.5	1.5	-0.7	-0.5	-0.1	-0.3	0.6	-1.2
Miserableness	4.3	7.5	28.4	0.2	0.6	-3.7	-1.2	-5.3	1.0
Guilty feelings	1.2	1.8	6.6	-1.1	-0.1	-2.6	0.5	-1.5	-0.6
Wears glasses or contact lenses	2.4	2.8	5.6	1.7	2.3	-0.1	-2.4	-1.2	1.0
Ever taken oral contraceptive pill	0.4	0.5	1.5	-0.8	0.1	0.1	-0.7	-1.2	0.2
Hearing aid user	1.3	1.4	4.0	-1.9	-0.2	-0.4	-0.3	-0.7	-2.0
Mother’s age at death	1.1	1.3	4.5	0.7	0.6	1.2	0.2	2.1	-1.1
Financial situation satisfaction	5.1	6.3	14.5	1.2	1.7	-1.6	-2.6	-3.1	3.8
Tinnitus: Yes, now most or all of the time	2.1	2.5	5.1	-1.4	1.8	-1.3	-2.3	-1.5	0.6
Commuting to job workplace: Public transport	1.7	2.1	6.7	-1.2	-0.2	-2.6	0.1	-1.9	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.6	0.2	0.3	-0.8	0.0	0.8
Medication: Blood pressure	1.6	3.1	6.2	-0.3	-2.4	0.4	1.7	1.9	-2.5
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.5	-0.4	-2.4	-1.0	1.9	-0.6	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.0	0.0	1.7	-0.2	-1.3	1.2	0.3
High cholesterol (Self-reported)	1.5	2.6	5.4	-1.0	-1.5	-1.4	0.4	-2.3	-2.3
Medication: Bendroflumethiazide	1.1	1.7	3.8	-0.9	-1.9	0.1	1.4	0.1	-1.8
Medication: Paracetamol	1.8	2.8	10.1	-1.0	-0.7	-2.0	-0.7	-3.2	-0.7
Medication: Lisinopril	0.4	0.6	1.2	-0.9	-1.0	-0.1	1.1	-0.1	0.6
Medication: Atorvastatin	1.3	1.6	5.4	-0.2	-1.8	-0.8	0.5	-2.3	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	0.3	0.3	-0.1	0.2	-0.1
Alcohol drinker status: Never	0.8	1.0	3.1	1.8	-1.3	0.2	-0.0	0.0	-1.1
Ever smoked	0.4	0.6	1.4	-1.2	-0.4	-0.8	-0.3	-0.6	1.1
Basal metabolic rate	1.3	7.4	19.0	4.1	-0.2	-2.9	0.2	-4.4	0.6
Leg fat percentage (left)	0.7	2.7	4.9	1.8	-1.4	-2.2	1.3	-0.9	-1.9
Arm fat-free mass (left)	0.9	4.6	11.7	3.4	-0.2	-2.0	0.3	-3.4	0.4
Number of operations (self-reported)	1.3	1.9	4.4	0.5	-1.7	-1.2	1.5	-2.1	-0.4
Average weekly beer plus cider intake	0.8	1.1	3.3	-0.3	1.8	-0.4	-1.2	-0.6	1.1
Irritability	2.2	3.7	10.6	-1.3	-0.2	-3.2	-0.7	-2.9	1.1
Risk taking	1.0	1.5	2.9	-1.2	0.6	-1.7	-0.9	-1.6	-1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.9	1.2	0.0	2.0	0.3	1.6	1.1
Fractured/broken bones in last 5 years	2.2	2.9	9.1	-1.5	-1.1	-3.0	1.1	-1.8	0.1
Age started oral contraceptive pill	0.6	0.7	1.4	1.0	0.1	0.2	1.1	0.8	-1.2
Diastolic blood pressure, automated reading	2.0	6.2	12.5	2.1	-3.3	0.0	3.5	1.4	-2.7
Ever depressed for a whole week	1.2	1.5	4.7	0.2	-0.2	-2.2	-0.1	-2.1	-0.2
Unable to work because of sickness or disability	1.7	2.2	4.2	0.4	-1.2	-2.0	2.0	-1.5	-1.2
Commuting to job workplace: Cycle	1.1	1.3	1.9	-1.4	-1.3	0.8	1.3	1.4	-0.3
Myopia	1.5	2.2	4.2	1.8	1.7	-0.3	-1.4	-2.0	0.7
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.5	-1.8	1.2	-1.3	-2.3	-2.1	1.2
Cholesterol lowering medication	2.6	3.8	7.3	-1.2	-2.6	-1.8	1.4	-1.3	-2.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	0.9	-0.1	0.7	-0.4	0.6	1.3
Pain experienced in last month	2.5	4.2	13.1	1.3	0.6	3.1	0.4	3.6	0.5
Supplements: Calcium	0.4	0.5	2.1	-0.1	-1.4	-0.5	0.3	-0.3	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.3	1.4	0.2	-0.2	0.0	1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.3	-1.0	0.5	0.5	0.6	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	-0.3	-0.3	-1.3	0.3	-1.3	-0.2
Heart disease (siblings)	1.7	2.1	5.1	-1.7	0.9	-1.1	-1.1	-1.3	2.2
Alcohol drinker status: Previous	0.5	0.6	1.7	0.5	-1.3	0.0	0.1	-0.7	-1.0
Pack years of smoking	1.2	1.7	7.2	0.7	0.3	-1.4	-0.7	-2.7	-0.4
Impedance of whole body	1.3	6.4	19.0	-3.4	-0.0	2.2	1.3	4.4	-0.9
Leg fat mass (left)	1.3	4.9	9.3	3.0	-1.3	-3.0	1.1	-2.5	-1.4
Arm predicted mass (left)	0.9	4.4	11.3	3.4	-0.2	-2.0	0.3	-3.3	0.3