Hub : Genes

MYO1H

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0840	0.0420	4.1e-03	0.053	0.025	0.044	NA	0.050	2.8e-05	3.4e-03	1.2e-04	NA	4.3e-05
2	TCGA	Breast Invasive Carcinoma	0.0835	0.0279	0.0e+00	0.117	0.097	0.099	NA	0.008	5.5e-23	3.0e-19	1.7e-19	NA	6.6e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0306	0.0192	4.9e-03	0.007	0.016	0.003	NA	0.005	4.3e-02	5.7e-03	1.4e-01	NA	8.6e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.2225	0.0668	2.7e-11	0.162	0.096	0.134	NA	0.146	8.4e-18	5.9e-11	7.4e-15	NA	4.1e-16
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0490	0.0300	4.7e-03	0.020	0.041	0.041	NA	0.026	2.5e-02	2.1e-03	2.1e-03	NA	1.2e-02
6	TCGA	Lung Adenocarcinoma	0.1336	0.0422	7.9e-15	0.154	0.143	0.155	NA	0.161	1.2e-17	2.0e-16	9.0e-18	NA	2.2e-18
7	TCGA	Lung Squamous Cell Carcinoma	0.0803	0.0446	8.2e-05	0.045	0.030	0.030	NA	0.038	7.6e-06	2.1e-04	2.2e-04	NA	3.7e-05
8	TCGA	Pancreatic Adenocarcinoma	0.1900	0.0780	4.8e-05	0.092	0.093	0.106	NA	0.102	1.1e-04	9.9e-05	3.4e-05	NA	4.7e-05
9	TCGA	Prostate Adenocarcinoma	0.0933	0.0418	5.7e-09	0.123	0.085	0.110	NA	0.115	9.1e-13	3.1e-09	1.6e-11	NA	5.2e-12
10	TCGA	Soft Tissue Sarcoma	0.0650	0.0360	8.2e-04	0.088	0.064	0.083	NA	0.090	6.8e-06	1.2e-04	1.2e-05	NA	5.4e-06
11	TCGA	Stomach Adenocarcinoma	0.0760	0.0360	9.6e-05	0.059	0.061	0.046	NA	0.057	4.1e-05	3.0e-05	2.9e-04	NA	5.6e-05
12	TCGA	Testicular Germ Cell Tumors	0.0990	0.0530	3.2e-03	0.060	0.089	0.098	NA	0.040	3.6e-03	4.6e-04	2.4e-04	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.4	1.6	-0.3	-0.8	-0.0	-0.4	-0.3	-0.8	-1.0	-0.5	0.2	-0.3	-1.3	-0.6
Bipolar Disorder or Schizophrenia	1.2	2.9	5.3	-0.0	-2.0	-2.0	-1.0	-2.2	-1.7	-2.1	-1.4	1.3	-1.0	-2.3	-2.0
Depressed Affect (Nagel 2018)	6.1	12.9	19.4	1.9	4.1	3.5	3.4	4.4	3.9	4.0	3.8	-4.1	3.2	2.9	3.2
Depression (Nagel 2018)	5.0	7.5	10.6	2.1	3.2	1.8	2.7	3.2	3.3	2.9	3.1	-3.0	2.7	2.3	2.1
Intelligence (Savage-Jansen 2018)	0.6	1.7	9.6	-3.1	1.3	0.3	0.4	0.2	0.9	1.6	0.6	-0.1	0.8	1.0	1.9
Neuroticism (Nagel 2018)	11.9	27.9	40.6	2.1	6.0	4.9	4.9	6.4	5.9	5.9	5.7	-5.7	4.7	4.7	5.1
Schizophrenia (2018)	1.5	3.1	7.2	0.2	-2.0	-2.7	-1.0	-2.6	-1.5	-1.9	-1.4	1.5	-1.1	-1.9	-2.0
Schizophrenia vs Biploar Disorder	0.9	1.2	5.6	1.4	-1.0	-2.4	-0.0	-1.8	-0.6	-1.1	-0.3	0.3	-0.3	-0.5	-0.9
Worry (Nagel 2018)	8.6	18.1	23.4	2.5	4.7	3.3	4.0	4.8	4.8	4.8	4.7	-4.7	4.2	4.1	3.8
Alzheimer’s Disease (in mother)	0.9	1.0	2.3	-0.7	0.6	1.0	1.4	1.1	0.3	0.5	0.7	-1.4	1.5	0.1	1.4
Alzheimer’s Disease (in father)	2.6	2.8	5.1	-1.7	-1.6	-1.9	-1.8	-2.3	-1.5	-0.9	-1.5	1.9	-1.8	-1.1	-1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	2.4	-1.6	-0.1	0.3	0.5	0.3	-0.6	-0.0	0.1	-0.6	0.6	-0.2	0.7
Crohns Disease (2017)	0.8	1.8	3.7	1.1	1.3	0.7	1.6	1.1	1.3	1.3	1.6	-1.8	1.9	1.2	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	1.3	1.0	0.1	0.8	0.5	1.1	0.6	1.0	-0.8	1.1	0.7	0.0
Ulcerative Colitis (UC)	0.1	0.1	0.9	0.9	0.5	-0.1	-0.1	0.2	0.6	-0.2	0.1	0.3	0.0	0.0	0.1
Major Depression (MDD)	4.1	4.9	8.9	1.6	2.4	0.8	2.9	1.9	2.4	2.2	2.9	-3.0	2.6	1.9	0.0
Reaction Time	0.3	0.5	1.5	-0.2	-0.8	-1.2	-0.5	-1.0	-0.6	-0.8	-0.5	0.8	-0.5	-0.9	-0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.8	6.0	-2.5	1.5	1.3	0.6	1.0	1.1	1.7	0.6	-0.5	0.7	1.1	2.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	2.2	2.9	4.8	-0.8	1.6	2.0	1.7	1.7	1.3	2.2	1.6	-1.8	1.8	2.0	1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.5	2.1	4.7	-0.9	-1.3	-1.2	-1.8	-1.6	-1.1	-1.2	-1.6	1.8	-2.2	-1.4	-1.1
Bipolar Disorder (2011)	0.4	0.4	1.5	0.0	-0.8	-0.1	-0.6	-0.4	-0.8	-0.9	-0.6	0.6	-0.5	-1.2	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.8	-0.1	0.4	0.4	1.7	0.4	-0.0	0.4	1.1	-1.5	1.6	1.0	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.0	-0.6	0.2	-0.7	0.2	-0.6	-0.6	-0.7	0.6	-0.5	-0.5	0.0
Crohns Disease (2012)	0.6	1.0	3.3	0.9	0.5	0.6	1.5	0.9	0.4	0.7	1.2	-1.5	1.8	0.6	-0.3
Mean Putamen Volume	0.5	0.6	1.3	-0.1	-0.9	-1.1	-0.6	-0.9	-0.8	-0.9	-0.5	0.8	-0.5	-0.8	-0.5
Fasting Glucose	1.6	1.9	5.1	-0.1	1.0	2.3	1.2	2.1	0.5	1.1	1.0	-1.3	1.3	1.7	1.5
HbA1C	2.2	2.5	3.6	1.4	1.7	0.9	1.5	1.3	1.9	1.6	1.5	-1.8	1.7	1.8	1.3
HDL Cholesterol	23.3	38.8	58.6	0.0	6.9	3.3	6.7	6.8	7.1	7.2	7.7	-7.2	7.0	7.3	0.0
LDL Cholesterol	0.1	0.1	0.4	0.0	0.6	-0.2	0.1	-0.4	0.5	0.5	0.1	-0.1	-0.5	-0.0	0.0
Lupus	0.3	0.4	1.2	0.0	-0.6	0.5	-0.8	0.2	-0.7	-1.1	-0.7	0.5	-0.8	-0.3	-0.6
Neuroticism (2016)	2.2	3.1	10.7	0.3	1.9	3.3	1.4	2.9	1.5	1.6	1.6	-1.7	1.5	0.9	0.0
Primary Biliary Cirrhosis	0.3	0.4	2.5	1.6	-0.5	-1.1	0.0	-0.4	-0.3	0.1	-0.0	0.1	0.5	0.4	-0.7
Rheumatoid Arthritis	0.3	0.5	1.7	-0.6	-0.1	-0.2	1.3	-0.3	-0.3	0.2	0.5	-1.1	1.3	0.1	0.1
Schizophrenia (2014)	2.0	4.5	9.3	0.7	-2.5	-3.1	-1.0	-3.0	-2.0	-2.5	-1.6	1.4	-1.1	-2.4	-2.5
Triglycerides	0.1	0.1	0.4	0.0	0.4	-0.3	0.4	-0.6	0.4	0.3	0.1	-0.3	-0.3	-0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.2	-1.1	0.3	0.4	0.7	0.3	0.2	0.0	0.4	-0.7	0.7	0.0	0.5
Ulcerative Colitis	0.3	0.4	2.9	1.7	0.5	0.2	0.4	0.6	0.6	-0.1	0.6	-0.3	0.6	0.4	-0.2
Blood Eosinophil Count	2.3	17.6	25.0	0.9	4.4	3.3	4.4	4.5	4.2	4.5	4.6	-4.5	4.9	5.0	3.6
Blood Platelet Count	0.3	3.4	26.1	-2.7	0.7	5.1	-0.5	2.2	0.1	-0.4	-0.8	0.6	-0.1	0.8	0.5
Blood Red Count	0.2	1.5	3.1	0.4	1.4	1.3	0.9	1.6	1.6	0.8	1.4	-0.7	1.1	0.5	1.8
Blood White Count	1.6	12.0	19.4	-0.2	3.4	3.2	3.8	3.6	3.1	3.9	3.7	-3.6	4.0	4.4	2.7
Heel T-Score	0.1	0.6	1.6	0.2	1.0	-0.6	0.5	0.3	1.3	0.6	1.1	-0.3	0.8	0.3	0.9
BMI	2.6	14.9	26.8	-0.6	3.3	2.5	5.2	3.5	2.6	4.1	4.5	-4.9	4.7	3.9	4.2
Height	0.3	5.6	12.3	3.3	1.9	-3.5	1.6	0.2	2.9	2.8	2.8	-1.7	1.4	2.1	2.1
Waist Hip Ratio (WHR)	0.2	0.9	4.0	0.8	-1.2	0.3	-0.8	-0.2	-1.1	-1.0	-0.8	0.7	-0.2	-1.1	-2.0
Systolic Blood Pressure	0.4	1.8	4.7	-1.3	-0.5	-1.9	-1.4	-2.1	-0.1	-0.6	-1.0	2.2	-1.2	-0.9	-1.2
Smoking Status	1.1	2.7	5.0	-1.2	1.8	2.2	1.6	1.9	1.4	1.6	1.5	-1.7	1.3	1.5	1.7
Allergy or Eczema	1.8	4.9	6.7	0.4	2.1	2.3	2.3	2.6	1.6	2.4	2.2	-2.5	2.3	2.2	2.6
Cardiovascular Disease	0.5	1.5	4.7	-2.2	1.1	-0.4	1.3	-0.3	1.1	1.7	1.3	-0.7	1.1	1.5	0.8
Hypothyroidism (self reported)	2.9	6.6	10.1	-0.2	2.4	3.2	3.0	3.1	1.9	2.5	2.6	-3.1	2.6	2.3	2.3
Respiratory disease	1.1	2.5	5.1	1.0	1.4	-0.2	2.3	0.8	1.5	1.5	2.1	-2.2	2.1	1.2	1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-0.5	0.3	0.3	1.2	0.6	0.4	0.9	1.0	-1.1	1.2	0.7	0.8
Lung FEV1/FVC ratio	1.3	6.5	10.4	0.9	2.7	2.5	3.2	2.6	2.2	1.9	2.7	-3.0	3.2	2.9	1.6
Lung FVC	0.9	4.8	10.2	3.2	-1.0	-2.6	-3.0	-1.5	0.1	-1.8	-1.5	2.6	-3.0	-1.8	-2.0
Neuroticism	9.4	22.6	31.5	1.8	5.4	4.2	4.3	5.6	5.1	5.6	5.0	-5.1	4.3	4.5	4.9
Chronotype (morning person)	1.6	3.7	7.3	0.1	1.9	2.6	1.7	2.7	1.4	2.0	1.7	-2.0	1.6	1.7	2.3
Hair Pigment	0.0	0.1	0.5	-0.7	0.3	0.3	0.0	0.1	0.5	-0.5	0.0	0.1	0.1	0.0	-0.6
Tanning	0.1	1.2	3.0	-0.3	-1.2	-0.5	-1.2	-1.3	-1.0	-0.5	-1.1	1.2	-1.3	-1.0	-1.7
Hand grip strength (left)	0.6	1.7	4.0	0.1	-1.1	-2.0	-1.5	-1.4	-0.9	-1.3	-1.3	1.5	-1.6	-1.2	-0.6
Number of treatments/medications taken	3.3	6.0	12.7	1.7	2.0	0.3	3.6	1.9	2.1	2.2	3.3	-3.4	3.4	2.1	1.2
Average weekly spirits intake	1.0	1.3	2.9	0.5	1.1	1.7	1.0	1.7	0.8	1.1	1.1	-1.1	0.9	1.1	1.0
Sensitivity / hurt feelings	11.3	19.4	26.3	1.1	4.8	3.8	4.3	5.1	4.6	4.7	4.8	-4.6	4.1	4.4	5.1
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.4	1.5	1.5	1.6	1.6	2.1	1.5	1.6	1.8	-1.9	2.0	1.3	0.6
Hearing difficulty/problems: Yes	12.5	19.2	24.6	1.8	4.4	3.4	4.6	5.0	4.2	4.5	4.7	-5.0	4.8	4.5	4.6
Relative age of first facial hair	0.9	1.9	5.1	2.3	1.2	0.2	1.3	1.5	1.2	1.1	1.5	-1.4	1.6	1.3	0.9
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.2	0.2	0.9	0.2	1.2	0.7	1.1	1.5	1.3	-1.3	1.1	0.6	0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	0.6	1.4	0.6	0.4	1.0	1.4	1.2	0.8	-0.4	0.3	1.3	0.9
Ever had hysterectomy (womb removed)	0.3	0.3	1.9	0.8	-0.6	-0.1	0.2	-0.1	-0.7	-0.5	0.0	-0.2	0.3	-0.5	-1.4
Systolic blood pressure, automated reading	0.2	0.6	2.4	-0.4	0.1	-1.6	-0.2	-1.6	0.4	0.2	-0.1	0.8	-0.0	-0.2	-1.2
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	4.5	0.3	1.4	1.2	2.1	1.5	1.1	1.2	1.6	-2.0	2.1	1.8	1.5
Angina	3.4	4.4	9.7	0.6	1.5	0.6	3.1	1.6	1.6	1.9	2.8	-2.9	3.1	1.9	1.3
Medication for hormone replacement therapy	4.2	4.7	8.0	1.3	2.2	1.1	2.1	2.1	2.1	2.5	2.2	-2.3	1.9	2.8	2.7
Vitamin and mineral supplements	1.6	2.2	3.4	-0.8	-1.4	-1.0	-1.6	-1.9	-1.1	-1.7	-1.8	1.7	-1.4	-1.4	-1.7
Supplements: Zinc	2.4	2.6	4.7	0.8	1.9	-1.2	1.9	0.3	2.2	1.7	2.2	-1.6	1.5	1.8	1.2
Medication: Co-codamol	1.5	1.7	3.6	-0.5	1.1	0.7	1.9	0.8	0.9	1.5	1.6	-1.8	1.9	1.1	0.8
Medication: Metformin	0.7	1.0	2.4	-0.9	0.5	0.1	1.6	0.4	0.6	1.0	1.2	-1.4	1.5	1.0	0.7
Diabetes (father)	3.6	4.4	7.4	0.1	2.7	1.7	2.0	2.2	2.5	2.2	2.2	-1.9	2.0	2.2	2.3
Diabetes (mother)	0.6	0.7	1.6	-1.3	-0.8	1.0	0.9	-0.3	-1.2	-0.7	-0.3	-0.8	1.2	-0.9	-0.6
Severe depression (siblings)	0.4	0.4	1.2	-1.1	0.3	0.7	0.8	0.5	0.2	-0.1	0.6	-0.8	0.6	-0.6	0.6
Pack years adult smoking proportion	1.8	2.7	4.8	0.6	1.6	1.3	1.8	1.8	1.4	2.1	1.8	-2.2	1.6	1.8	1.3
Impedance of leg (right)	1.3	6.4	12.3	-2.2	-1.7	-0.5	-3.1	-2.1	-1.8	-3.1	-3.0	3.5	-3.2	-2.5	-2.0
Leg fat-free mass (left)	2.4	12.5	18.9	3.4	2.8	-0.5	4.2	2.7	3.1	3.9	4.3	-4.3	4.0	3.8	3.6
Trunk fat percentage	1.4	5.6	10.2	0.7	2.2	0.9	3.2	2.2	2.0	2.4	3.1	-2.7	3.2	2.2	2.2
Hand grip strength (right)	0.5	1.5	5.6	1.5	-0.9	-2.4	-1.5	-1.1	-0.5	-0.7	-0.9	1.4	-1.3	-0.6	-0.5
Townsend deprivation index at recruitment	3.8	5.4	11.6	1.5	1.7	1.6	3.3	2.2	1.2	2.1	2.8	-3.4	3.3	1.9	1.0
Current tobacco smoking	1.0	1.6	5.7	-1.2	1.0	2.4	1.4	1.6	0.4	0.7	0.8	-1.6	1.1	0.6	1.1
Average weekly fortified wine intake	2.1	2.5	4.1	-1.3	-1.5	0.3	-1.9	-0.9	-1.9	-1.5	-2.0	2.0	-1.5	-1.8	-1.4
Maternal smoking around birth	6.3	9.2	15.6	0.5	3.1	0.9	3.9	2.5	2.9	3.0	3.9	-3.7	3.9	2.6	3.0
Fed-up feelings	2.6	4.7	9.1	1.0	2.2	2.8	2.2	3.0	1.8	2.0	2.2	-2.5	2.3	1.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	9.9	0.9	2.4	3.0	2.1	3.1	1.9	2.0	2.1	-2.3	2.1	1.9	1.7
Relative age voice broke	0.2	0.2	0.6	0.0	0.2	0.1	0.6	0.6	0.3	0.3	0.6	-0.7	0.6	-0.1	0.8
Taking other prescription medications	3.7	5.7	11.2	3.3	1.4	0.1	3.3	1.7	1.8	1.9	3.1	-3.3	3.2	2.0	0.2
Age when periods started (menarche)	4.0	9.5	14.2	2.3	3.6	1.2	3.2	2.9	3.8	3.5	3.6	-3.5	2.8	3.2	2.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.5	0.3	0.1	-0.1	0.6	-0.3	0.1	-0.0	0.2	-0.7	0.4	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	-0.2	0.2	-0.4	-0.5	-0.6	0.1	-0.4	-0.7	0.9	-0.6	-0.0	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.7	0.8	-0.6	-1.3	-0.3	-0.6	-0.5	-0.7	-0.0	0.5	0.0	-0.0	-0.7
Qualifications: CSEs or equivalent	1.8	2.3	5.8	1.2	1.1	0.2	2.3	1.0	1.1	1.0	1.9	-2.4	2.2	1.1	1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.8	1.0	0.9	-0.2	0.6	0.4	1.2	1.4	0.9	-0.7	0.7	0.8	-0.0
High blood pressure	0.8	2.1	6.1	-2.0	-1.0	-2.1	-0.9	-2.5	-0.8	-0.7	-0.8	1.5	-0.9	-1.2	-1.7
Hayfever, allergic rhinitis or eczema	1.3	2.8	6.8	-0.3	1.3	2.6	1.5	2.2	0.9	1.6	1.3	-1.7	1.6	1.6	2.3
Multivitamins +/- minerals	0.2	0.2	0.5	0.2	0.3	0.2	0.7	0.5	0.0	0.3	0.7	-0.5	0.6	0.3	0.5
Stomach or abdominal pain in last month	0.7	0.9	2.7	0.3	0.7	1.6	1.1	1.2	0.4	0.7	0.9	-1.2	0.9	0.8	0.5
Supplements: Glucosamine	0.1	0.2	0.5	0.7	0.6	0.1	-0.1	0.1	0.7	-0.6	0.1	0.3	0.1	-0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.0	0.8	-1.6	-1.6	-1.3	-1.6	-1.2	-1.1	-1.3	1.1	-1.2	-1.1	-2.0
Medication: Atenolol	0.3	0.4	1.0	0.8	0.5	-0.4	0.6	0.2	0.7	0.8	0.9	-0.4	0.7	1.0	-0.2
Medication: Levothyroxine sodium	1.2	2.0	4.5	-0.4	0.8	1.8	2.0	1.6	0.6	1.0	1.4	-2.1	1.9	1.0	0.7
Sitting height	0.4	3.1	15.1	3.8	-1.1	-3.9	-1.0	-1.4	-0.2	-0.6	-0.2	0.8	-1.4	0.0	-0.4
Chronic bronchitis/emphysema (father)	4.3	5.1	8.6	0.2	1.9	1.1	2.8	1.6	1.8	2.8	2.5	-2.9	2.9	2.8	1.9
High blood pressure (mother)	0.3	0.5	2.4	-0.8	-0.1	-1.5	0.5	-1.4	0.2	0.2	0.3	-0.2	0.5	0.3	-0.3
Body mass index (BMI)	1.9	7.9	13.6	1.3	2.4	1.2	3.7	2.6	2.1	3.0	3.4	-3.5	3.5	2.8	2.8
Impedance of leg (left)	1.5	7.2	13.3	-2.4	-1.9	0.2	-3.3	-1.8	-2.1	-3.4	-3.2	3.6	-3.2	-2.8	-2.3
Leg predicted mass (left)	2.3	12.3	18.5	3.4	2.8	-0.6	4.1	2.6	3.0	3.8	4.3	-4.3	4.0	3.8	3.6
Trunk fat mass	1.9	8.1	14.1	1.5	2.5	0.4	3.8	2.4	2.4	2.8	3.7	-3.3	3.7	2.7	2.9
Waist circumference	1.6	5.9	11.9	2.0	1.8	0.5	3.3	2.2	1.6	2.4	3.0	-3.1	3.4	2.3	2.0
Number of incorrect matches in round	1.7	2.8	6.1	0.5	-2.1	-2.0	-1.0	-1.8	-1.9	-2.1	-1.1	1.4	-1.2	-2.5	-1.6
Past tobacco smoking	0.8	1.5	3.3	0.5	-1.4	-1.8	-0.5	-1.7	-1.4	-1.6	-1.0	0.6	-0.5	-1.4	-1.4
Alcohol usually taken with meals	1.1	1.8	4.6	0.0	-1.5	-2.1	-1.4	-1.6	-1.2	-1.4	-1.3	1.4	-1.4	-0.8	-0.8
Nervous feelings	5.3	9.9	14.3	2.0	3.0	3.0	3.4	3.8	2.8	3.1	3.4	-3.6	3.7	3.2	2.3
Frequency of tenseness / restlessness in last 2 weeks	9.3	14.4	18.4	1.3	3.9	3.5	3.9	4.2	3.5	4.2	3.9	-4.3	4.0	3.8	4.1
Hearing difficulty/problems with background noise	7.0	11.2	16.0	-0.4	3.4	3.6	3.6	4.0	3.0	3.4	3.5	-3.7	3.6	2.9	3.6
Hair/balding pattern: Pattern 2	1.0	1.2	2.8	0.5	-1.4	-0.8	-1.0	-0.8	-1.2	-1.7	-1.0	1.2	-0.9	-1.2	-1.0
Had menopause	0.7	0.9	2.3	-0.3	-0.8	-0.7	-1.0	-1.2	-0.7	-1.1	-0.9	1.1	-1.0	-0.7	-1.5
Had other major operations	0.1	0.2	0.8	0.3	-0.4	-0.2	0.3	-0.3	-0.6	-0.2	-0.1	-0.4	0.5	0.1	-0.9
Forced vital capacity (FVC)	0.5	1.8	10.1	3.2	0.2	-2.2	-1.3	-0.4	1.2	-0.1	0.0	0.9	-1.6	0.4	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	-0.7	0.0	-0.1	-0.6	-0.3	-0.2	-0.7	-0.8	1.0	-0.4	-0.3	0.6
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.3	0.9	2.1	1.1	1.8	2.3	2.1	1.9	2.2	-2.0	1.7	1.6	1.4
Qualifications: None of the above	1.1	2.4	20.1	4.5	0.6	-1.9	0.3	0.0	1.5	0.3	1.1	-0.6	-0.1	0.3	-0.7
Financial difficulties in last 2 years	1.8	2.5	4.3	0.8	1.7	1.3	1.3	1.9	1.5	2.1	1.6	-1.6	1.4	1.7	1.7
Mouth/teeth dental problems	10.0	15.4	18.4	-0.6	-4.2	-3.5	-4.0	-4.3	-3.9	-4.3	-4.2	4.2	-4.2	-4.2	-4.0
Heart attack	0.3	0.3	1.5	0.3	0.4	-0.2	0.9	0.3	0.3	0.2	0.6	-0.6	1.2	0.5	0.5
Allergy	3.2	7.5	11.2	0.4	-2.5	-3.4	-2.9	-3.1	-2.0	-2.8	-2.5	3.1	-2.8	-2.7	-3.2
Pain all over the body in last month	2.5	2.7	5.9	0.1	1.3	1.9	1.4	2.2	1.1	2.4	1.4	-1.8	1.4	1.9	1.4
Diabetes (self-reported)	0.5	0.7	1.4	0.9	0.4	-0.9	1.1	0.2	0.8	0.6	1.2	-1.0	1.2	0.8	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.8	-0.8	0.5	-0.3	-0.1	-1.0	-0.3	-0.6	0.3	-0.1	-0.0	-0.1
Medication: Ramipril	0.9	1.2	3.2	-1.0	-1.1	-1.4	0.0	-1.8	-1.2	-1.2	-0.6	0.6	-0.2	-1.3	-1.1
Medication: Simvastatin	2.4	3.5	7.2	0.4	1.8	0.7	2.7	1.3	1.8	1.8	2.4	-2.5	2.4	1.9	1.3
Fluid intelligence score	0.7	1.4	4.1	-2.0	1.3	1.4	0.2	1.0	0.7	1.2	0.3	-0.1	0.3	1.1	2.0
Illnesses of siblings	1.1	1.6	2.2	-0.7	-1.5	-0.7	-1.5	-1.4	-1.4	-0.9	-1.5	1.3	-1.4	-1.3	-1.3
Neuroticism score	8.0	16.6	26.1	1.6	4.6	4.2	3.6	5.1	4.3	4.7	4.2	-4.2	3.6	3.9	3.9
Weight	2.4	11.7	18.7	2.9	2.8	-0.3	4.3	2.7	2.8	3.5	4.3	-4.2	4.2	3.5	3.5
Impedance of arm (right)	0.1	0.5	3.2	-1.8	0.3	1.3	-0.4	0.3	0.2	-0.3	-0.2	0.7	-0.1	-0.5	-0.5
Arm fat percentage (right)	2.1	8.1	13.8	0.4	2.7	1.8	3.7	2.8	2.3	3.0	3.5	-3.3	3.7	2.6	2.7
Trunk fat-free mass	1.0	6.0	14.1	3.8	1.5	-2.0	2.6	1.2	1.8	2.2	2.8	-2.8	2.5	2.5	2.7
Hip circumference	2.9	12.3	18.3	2.0	3.2	0.8	4.3	3.1	3.0	3.7	4.1	-4.1	4.2	3.9	3.9
Time employed in main current job	0.5	0.6	1.2	0.8	-0.8	-0.8	-0.5	-0.9	-0.5	-0.9	-0.6	0.4	-0.2	-1.0	-1.1
Alcohol intake versus 10 years previously	0.3	0.4	1.8	1.3	0.2	-0.5	0.4	0.7	0.3	0.4	0.7	-0.4	0.7	0.7	0.3
Father’s age at death	0.4	0.5	2.5	0.2	-0.1	1.6	-0.9	1.1	-0.3	-0.5	-0.7	0.7	-0.7	0.1	0.2
Worrier / anxious feelings	7.4	14.0	20.3	1.1	4.2	3.6	3.3	4.5	4.0	4.3	4.1	-3.7	3.7	3.9	3.2
Frequency of tiredness / lethargy in last 2 weeks	15.1	24.4	34.5	2.4	5.0	4.4	5.0	5.9	4.6	5.4	5.3	-5.6	4.8	5.1	5.0
Falls in the last year	8.1	10.9	16.6	0.3	3.1	2.8	3.9	3.5	2.7	3.9	3.7	-4.1	3.9	3.7	2.3
Hair/balding pattern: Pattern 3	0.2	0.3	2.3	-0.6	0.2	-0.2	0.3	-0.1	0.1	0.7	0.3	-0.3	0.1	0.2	1.5
Number of live births	0.4	0.6	2.4	0.0	0.6	-0.3	0.7	0.0	0.7	1.6	0.8	-0.9	0.6	1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	8.5	2.9	0.0	-2.1	-1.4	-0.7	0.9	-0.6	-0.3	1.2	-1.7	0.0	-0.3
Pulse rate	1.4	2.4	5.4	0.2	1.4	2.3	1.6	2.0	1.2	1.6	1.6	-1.7	1.8	1.3	0.9
Happiness	0.7	0.8	2.0	0.5	0.9	0.9	0.7	1.4	0.8	0.6	1.0	-0.7	1.3	0.8	0.8
Noisy workplace	1.4	1.8	4.4	0.5	0.6	-0.4	2.0	0.7	0.6	1.4	1.7	-2.1	2.1	1.1	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.3	-1.5	-0.3	0.2	-0.7	-0.4	-0.5	-0.2	-0.7	0.7	-0.7	-0.2	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.3	-0.4	-1.3	-1.3	-0.4	-1.5	-1.2	-1.6	-0.8	0.4	-0.4	-1.8	-0.7
Mouth/teeth dental problems: Dentures	4.2	7.1	11.9	-0.1	2.9	3.4	2.7	3.2	2.4	2.6	2.6	-2.7	2.6	2.6	2.7
Asthma	1.2	2.4	5.0	-0.4	1.4	1.7	2.2	1.4	1.0	1.2	1.6	-2.2	2.2	1.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	1.3	0.4	0.9	1.0	1.6	0.4	0.3	0.9	-1.2	1.2	0.4	0.3
Medication: Cholesterol lowering	3.1	4.8	9.1	1.0	1.9	0.6	3.0	1.7	1.9	2.3	2.6	-2.9	3.0	2.2	1.7
Depression (self-reported)	0.6	0.7	4.2	2.1	0.7	0.5	0.5	1.0	0.7	0.5	0.7	-0.8	0.7	0.2	-0.1
Medication: Lansoprazole	0.9	1.0	2.5	1.6	0.9	-1.1	0.7	-0.2	1.6	1.1	1.3	-0.7	0.8	0.4	-0.6
Prospective memory result	1.0	1.2	4.6	2.1	-1.2	-2.1	0.2	-1.0	-0.7	-0.9	0.0	-0.4	-0.3	-0.4	-1.2
Lung cancer (father)	4.1	4.8	7.5	0.4	2.6	2.5	2.0	2.7	2.5	2.4	2.3	-2.1	2.0	2.1	1.8
Illnesses of mother	1.2	1.5	3.9	1.5	-0.8	-0.4	-1.8	-0.4	-0.7	-1.1	-1.3	1.5	-2.0	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	7.9	2.8	0.8	-1.3	-0.2	0.4	1.4	0.3	0.7	0.1	-0.4	0.9	0.9
Pulse wave Arterial Stiffness index	2.7	3.2	5.2	-0.3	2.3	1.6	1.7	1.9	2.0	2.3	1.9	-1.7	1.5	1.7	1.7
Impedance of arm (left)	0.2	0.8	3.2	-1.8	-0.2	0.6	-0.8	-0.4	-0.2	-0.7	-0.6	1.1	-0.5	-1.0	-1.1
Arm fat mass (right)	2.3	9.6	15.8	1.5	2.8	1.0	4.0	2.9	2.6	3.3	3.8	-3.7	3.9	3.1	3.2
Trunk predicted mass	1.0	5.8	13.6	3.7	1.4	-2.0	2.5	1.2	1.8	2.2	2.7	-2.7	2.4	2.5	2.7
Standing height	0.4	4.1	13.1	3.6	1.1	-3.2	1.7	0.4	1.8	1.4	2.3	-1.7	1.6	1.8	1.8
Length of working week for main job	0.3	0.3	1.5	-0.7	0.4	0.4	0.4	0.7	0.1	0.1	0.5	-0.4	0.1	0.4	1.2
Exposure to tobacco smoke at home	0.8	0.9	2.2	-0.2	0.7	0.5	1.1	0.6	0.6	0.9	0.8	-1.2	1.1	1.2	1.5
Breastfed as a baby	1.9	2.3	3.8	0.6	-1.8	-1.0	-1.9	-1.4	-1.6	-1.1	-1.9	1.9	-1.7	-1.2	-1.6
Tense / ‘highly strung’	0.3	0.5	1.2	0.2	0.9	0.9	0.8	0.6	0.7	0.5	0.7	-1.1	0.7	0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.0	1.0	0.8	1.2	1.5	1.5	0.6	0.7	1.3	-1.7	1.2	0.5	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	1.3	1.0	-0.9	1.1	0.1	1.4	1.2	1.4	-1.0	1.0	1.2	0.6
Birth weight of first child	0.8	1.4	4.7	2.2	0.1	-2.0	1.2	-0.2	0.6	0.6	1.4	-1.5	1.4	0.3	-0.1
Peak expiratory flow (PEF)	3.7	8.6	13.6	0.6	-2.9	-2.6	-3.2	-2.7	-2.6	-3.7	-3.0	3.3	-3.5	-3.2	-2.5
Pulse wave reflection index	1.1	1.4	2.4	-0.5	1.6	1.1	1.2	1.5	1.4	0.9	1.3	-1.0	1.2	0.9	1.2
Ever highly irritable/argumentative for 2 days	5.6	6.7	10.0	1.1	2.9	2.4	2.6	3.2	2.7	2.7	2.9	-2.7	2.4	2.5	2.2
Loud music exposure frequency	0.8	0.9	2.7	-1.2	0.5	1.6	0.9	1.2	0.1	0.7	0.7	-0.9	1.4	0.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	2.6	-1.6	-0.1	1.0	-0.1	0.0	-0.5	-0.3	-0.3	0.2	0.2	-0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	9.1	11.8	17.0	0.6	3.6	2.4	3.5	3.7	3.5	3.5	3.7	-3.6	3.7	3.7	4.1
Blood clot in the leg (DVT)	1.3	1.7	3.3	0.3	1.1	1.2	1.8	1.4	1.1	1.2	1.6	-1.8	1.5	1.0	1.0
Medication: Paracetamol	6.0	9.9	17.4	1.3	2.9	3.5	3.7	3.9	2.4	2.7	3.2	-4.2	3.6	2.7	2.5
Headache pain in last month	3.3	5.7	12.2	0.4	1.6	2.2	3.4	2.5	1.2	1.7	2.7	-3.5	3.4	2.2	1.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	0.4	-0.0	1.3	-1.0	0.9	-0.2	-0.6	-0.8	0.7	-0.9	-0.2	0.5
Glaucoma (self-reported)	0.7	0.8	3.2	-0.9	-0.5	0.4	1.6	0.4	-0.6	-0.3	0.7	-1.2	1.8	-0.5	-0.4
Gout (self-reported)	3.0	4.1	6.3	0.1	-2.4	-0.9	-2.2	-1.5	-2.4	-2.5	-2.3	2.3	-1.8	-1.9	-2.2
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	8.3	0.5	2.1	2.6	2.6	2.9	1.7	1.9	2.2	-2.8	2.3	2.0	1.9
Medication: Amlodipine	0.6	0.9	1.8	-0.5	-0.9	-0.0	-0.9	-0.6	-1.0	-1.1	-1.1	1.1	-1.0	-1.4	-0.8
Medication: Ventolin 100micrograms inhaler	4.1	5.2	9.0	1.3	2.5	1.4	2.3	2.0	2.5	3.0	2.6	-2.6	2.3	2.8	1.6
Birth weight	0.1	0.1	0.4	0.6	-0.4	-0.4	0.0	-0.2	-0.6	-0.4	-0.3	-0.1	-0.2	-0.4	-0.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.4	0.7	1.4	1.2	1.4	1.5	1.3	1.3	1.4	-1.6	1.3	1.5	0.9
High blood pressure (siblings)	0.3	0.4	1.0	0.1	-0.5	-0.2	-0.8	-0.2	-0.6	-0.9	-0.9	1.0	-0.9	-0.5	0.0
Forced vital capacity (FVC), Best measure	0.5	1.7	9.4	3.1	1.0	-1.5	-0.2	0.5	1.7	0.7	0.9	-0.1	-0.4	1.2	1.2
Body fat percentage	1.3	5.3	9.7	0.3	2.2	1.2	3.1	2.2	1.9	2.3	2.9	-2.6	3.0	2.0	2.3
Leg fat percentage (right)	1.2	4.2	8.9	0.4	2.0	0.8	3.0	1.6	1.7	1.9	2.6	-2.5	2.8	1.8	1.8
Arm fat-free mass (right)	0.9	4.8	12.3	3.5	1.4	-1.5	2.2	1.3	1.7	2.0	2.5	-2.4	2.0	2.3	2.5
Exposure to tobacco smoke outside home	5.0	6.6	11.2	-0.7	2.6	1.8	3.3	2.1	2.3	2.7	2.8	-3.3	3.0	2.3	2.8
Comparative body size at age 10	0.9	2.4	3.6	-0.1	1.9	0.7	1.8	1.1	1.8	1.6	1.9	-1.6	1.5	1.8	1.8
Number of full brothers	1.5	1.9	3.2	-1.2	1.2	1.2	1.7	1.1	1.0	1.4	1.3	-1.8	1.6	1.2	1.3
Worry too long after embarrassment	6.8	11.5	17.7	0.5	3.8	3.7	2.9	4.2	3.6	3.7	3.4	-3.3	2.8	3.4	3.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.1	0.1	0.6	0.0	0.6	-0.1	0.3	0.2	-0.2	0.1	-0.5	0.3
Wheeze or whistling in the chest in last year	1.2	2.2	5.4	0.2	1.3	2.3	1.6	2.0	1.0	1.5	1.5	-1.7	1.8	0.9	0.9
Number of children fathered	0.1	0.1	0.5	0.7	0.3	0.1	-0.3	0.2	0.3	0.1	-0.3	-0.1	-0.5	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	5.2	-0.8	-1.1	-1.7	-1.1	-2.3	-0.9	-0.9	-1.0	1.5	-1.2	-1.0	-1.3
Age at first live birth	0.8	1.4	3.0	-0.8	-0.9	0.2	-1.7	-0.7	-1.0	-1.1	-1.7	1.7	-1.6	-0.9	-0.9
Pulse wave peak to peak time	2.2	2.6	4.4	0.6	-2.1	-1.8	-1.4	-1.8	-1.8	-2.0	-1.6	1.4	-1.3	-1.5	-1.5
Health satisfaction	3.3	4.3	8.3	1.5	1.7	0.9	2.8	2.0	1.7	1.9	2.7	-2.9	2.6	2.3	1.1
Shortness of breath walking on level ground	1.5	1.7	3.3	1.0	1.1	-0.0	1.8	0.7	1.2	1.3	1.8	-1.8	1.8	1.3	0.7
Qualifications: College or University degree	0.1	0.3	1.6	-1.2	-0.1	-0.0	-0.4	-0.3	-0.3	0.3	-0.4	0.1	-0.4	0.4	0.7
Eye problems/disorders: None of the above	0.8	0.9	2.5	-0.5	-0.3	0.1	-1.5	-0.4	-0.5	-0.6	-1.3	1.4	-1.6	-0.7	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.5	0.3	0.9	0.6	0.5	0.1	0.8	0.3	-0.7	0.8	0.7	0.1
Emphysema/chronic bronchitis	1.1	1.2	2.0	1.4	1.1	0.1	1.2	0.9	1.0	1.1	1.1	-1.3	1.2	1.2	1.2
Medication for pain relief, constipation, heartburn	2.6	4.4	9.2	-2.7	-1.4	-1.4	-2.7	-2.6	-1.2	-1.0	-2.3	2.9	-3.0	-1.5	-0.6
Neck or shoulder pain in last month	5.7	8.1	12.3	2.2	2.9	2.3	3.2	3.5	2.8	2.1	3.4	-3.5	3.2	2.5	2.0
Medication: Blood pressure	0.9	1.6	5.2	-0.3	-1.1	-2.3	-0.9	-2.0	-0.7	-0.6	-0.7	1.2	-0.8	-1.1	-1.7
Angina (self-reported)	3.7	4.9	10.6	0.4	1.6	0.9	3.2	1.7	1.7	2.1	2.8	-3.1	3.3	2.1	1.4
Migraine (self-reported)	1.1	1.4	5.4	-0.5	-0.0	2.3	1.6	1.4	-0.5	-0.4	0.6	-1.5	1.7	0.1	-0.2
Medication: Ibuprofen	2.2	2.6	5.3	0.9	1.4	1.6	1.9	2.3	1.3	1.2	1.8	-2.0	2.0	1.1	1.2
Medication: Allopurinol	1.7	2.3	3.9	-0.2	-1.6	-1.0	-1.6	-1.2	-1.6	-2.0	-1.6	1.8	-1.8	-1.3	-1.7
Medication: Omeprazole	0.3	0.3	1.5	1.0	-0.2	-1.2	0.1	-0.6	0.2	-0.2	0.2	-0.1	-0.1	-0.2	-0.9
Medication: Seretide 50 evohaler	0.3	0.4	1.7	-0.7	-0.1	-0.5	1.0	-0.2	-0.3	0.1	0.7	-0.7	1.3	-0.2	0.4
Mean time to correctly identify matches	0.2	0.3	0.9	-0.0	-0.5	-0.7	-0.4	-0.6	-0.4	-0.6	-0.4	0.6	-0.2	-1.0	-0.6
Heart disease (mother)	0.8	0.9	1.5	-0.2	1.2	0.8	0.9	0.9	1.0	1.2	1.1	-0.6	1.2	1.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.5	0.2	0.2	-0.5	-0.9	-0.2	0.4	-0.2	-0.5	0.9	-1.2	-0.6	0.6
Whole body fat mass	2.1	8.6	15.0	1.4	2.6	0.7	3.9	2.6	2.4	3.0	3.8	-3.5	3.7	2.8	3.0
Leg fat mass (right)	2.2	8.3	15.0	1.3	2.6	0.7	3.9	2.5	2.4	2.9	3.6	-3.5	3.6	2.8	2.9
Arm predicted mass (right)	0.9	4.7	10.9	3.3	1.4	-1.5	2.3	1.2	1.6	2.0	2.5	-2.4	2.0	2.3	2.5
Pulse rate, automated reading	1.9	6.1	9.0	-0.3	2.4	2.6	2.7	2.8	2.3	3.0	2.7	-2.9	2.6	2.2	1.9
Alcohol intake frequency.	0.3	0.6	1.6	0.6	-0.8	-1.3	0.8	-0.8	-0.8	-0.2	0.4	-0.6	1.1	0.1	-0.9
Comparative height size at age 10	0.8	4.3	16.0	2.4	-2.0	-4.0	-1.5	-2.4	-1.5	-2.2	-1.3	1.7	-1.4	-1.5	-1.6
Number of full sisters	0.3	0.4	1.3	-1.0	0.0	0.8	-0.8	-0.0	-0.0	0.6	-0.6	0.4	-1.1	0.2	-0.1
Suffer from ‘nerves’	3.9	6.1	9.9	1.8	2.6	2.4	2.4	3.1	2.4	2.2	2.6	-2.7	2.5	2.3	2.3
Overall health rating	3.9	8.3	18.5	1.8	2.5	1.4	4.3	2.3	2.4	2.3	3.8	-4.1	4.0	2.2	1.0
Chest pain or discomfort	1.3	1.9	4.0	-0.1	1.2	0.6	2.0	0.8	1.0	1.5	1.8	-2.0	2.0	1.1	0.6
Had major operations	1.3	1.5	3.0	0.4	1.1	0.2	1.6	0.9	1.1	1.5	1.5	-1.5	1.7	1.3	1.1
Age at last live birth	0.4	0.5	1.6	-0.8	0.1	0.3	-1.3	-0.4	0.1	0.4	-0.9	1.0	-1.2	-0.0	-0.2
Family relationship satisfaction	0.1	0.2	0.5	0.7	0.4	0.3	-0.2	0.7	0.2	-0.4	0.2	0.3	0.4	0.2	0.0
Leg pain on walking	0.4	0.5	2.5	1.1	-0.4	-1.6	0.3	-1.0	-0.1	-0.5	0.3	-0.2	-0.0	0.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.1	-0.7	0.3	-0.0	1.6	0.3	0.2	0.2	1.1	-1.2	1.8	-0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-1.1	-0.8	0.3	-0.4	-0.2	-1.1	-0.8	-0.7	0.5	-0.1	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.8	-0.5	-0.1	-0.5	-0.7	-0.6	-1.1	-0.6	0.7	-0.5	-0.6	-1.0
Medication: Aspirin	1.6	2.1	6.7	0.5	0.7	0.1	2.3	1.0	0.7	1.0	1.8	-2.1	2.6	1.2	0.6
Supplements: Vitamin C	1.4	1.7	3.0	1.0	1.1	0.0	1.7	1.0	1.3	1.2	1.7	-1.7	1.2	1.2	1.5
Knee pain experienced in last month	5.0	7.7	13.0	2.0	2.7	0.1	3.3	2.1	2.9	2.6	3.5	-3.2	3.6	2.8	2.6
Hypertension (Self-reported)	0.7	1.8	5.7	-2.2	-0.9	-1.9	-0.6	-2.4	-0.7	-0.6	-0.6	1.2	-0.6	-1.0	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	2.3	1.5	-1.5	-1.5	-1.0	-1.2	-0.9	-1.3	-0.8	0.8	-1.1	-1.1	-1.4
Illnesses of father: Heart disease	2.2	3.1	5.0	-0.1	1.7	1.9	2.0	2.1	1.2	1.3	1.8	-1.7	2.2	1.8	2.2
Illnesses of siblings: Diabetes	0.2	0.2	1.6	-0.0	-0.2	1.3	0.1	0.6	-0.5	-0.7	-0.3	-0.0	0.0	0.1	0.0
Smoking status: Previous	0.4	0.5	1.4	0.1	1.0	0.5	0.2	0.8	1.2	1.2	0.8	-0.1	0.3	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.9	2.0	1.2	0.2	0.5	1.4	1.2	1.2	1.0	-0.8	0.6	2.1	2.2
Whole body fat-free mass	1.5	8.5	13.6	3.7	2.1	-1.4	3.3	1.9	2.4	3.0	3.5	-3.5	3.1	3.1	3.2
Leg fat-free mass (right)	2.1	11.2	17.2	3.4	2.6	-0.4	4.0	2.7	2.8	3.5	4.1	-4.2	3.9	3.5	3.3
Arm fat percentage (left)	1.7	6.8	11.6	0.4	2.4	1.6	3.4	2.6	2.1	2.6	3.2	-3.0	3.4	2.3	2.5
Average weekly red wine intake	0.3	0.4	1.5	-1.2	-0.2	-0.6	-0.7	-0.9	-0.1	-0.4	-0.6	0.8	-0.7	-0.1	0.1
Handedness (chirality/laterality): Left-handed	2.1	2.5	4.6	-1.7	-1.9	-1.2	-1.0	-1.6	-1.9	-2.0	-1.4	1.2	-0.9	-2.1	-1.3
Mood swings	6.1	11.0	16.6	1.4	3.6	2.3	3.9	3.5	3.4	3.6	3.9	-4.1	3.4	2.6	3.1
Loneliness, isolation	0.3	0.4	1.1	0.7	0.7	1.1	0.2	1.0	0.7	0.4	0.6	-0.3	0.3	0.2	0.1
Long-standing illness, disability or infirmity	5.0	7.7	14.7	1.7	2.5	0.2	3.7	1.9	2.8	3.2	3.7	-3.8	3.6	2.3	1.3
Ever had bowel cancer screening	0.9	1.0	8.4	2.9	-0.5	-1.5	-0.3	-0.2	-0.0	-0.2	0.1	-0.0	-0.1	-0.1	-1.2
Diabetes diagnosed by doctor	0.2	0.3	1.1	0.2	0.1	-0.4	1.1	0.2	0.3	0.3	0.8	-0.9	1.0	0.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.3	-0.1	-0.1	0.6	-0.2	0.1	0.6	0.4	-0.7	0.6	0.3	-0.6
Friendships satisfaction	0.1	0.1	0.8	0.2	0.1	-0.9	-0.0	-0.3	0.1	0.0	0.3	0.1	-0.1	0.2	0.3
Qualifications: nursing, teaching	0.5	0.8	7.6	-2.8	0.3	0.5	0.3	-0.3	-0.2	0.2	-0.1	0.1	0.0	0.5	1.0
Commuting to job workplace: Walk	0.9	1.0	1.5	0.8	0.6	0.2	1.2	0.8	0.7	1.0	1.1	-1.2	1.2	1.0	1.2
Eye problems/disorders: Cataract	0.6	0.7	1.5	-0.5	0.4	0.8	1.2	0.8	0.4	0.7	1.0	-1.2	1.2	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.3	0.4	1.6	0.6	0.7	1.3	1.7	1.8	1.4	-0.8	1.0	1.7	1.7
Medication for cholesterol	4.0	6.1	8.0	1.9	-2.8	-2.2	-2.8	-1.9	-2.4	-2.5	-2.6	2.6	-2.5	-2.6	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.9	1.7	0.6	-0.7	0.7	0.3	0.8	0.8	1.0	-0.8	0.8	0.7	0.2
Back pain experienced in last month	4.6	6.6	9.4	2.0	2.9	1.5	2.7	2.6	2.9	2.5	3.1	-3.0	2.4	3.1	2.0
Mineral and other dietary supplements	0.3	0.4	1.7	-1.3	-0.9	-0.3	-0.2	-0.8	-0.9	-0.2	-0.6	0.2	-0.5	-0.4	-0.3
Breast cancer (self-reported)	0.3	0.3	0.9	0.8	0.4	0.2	0.8	0.7	0.2	0.2	0.5	-0.8	0.9	0.2	0.4
Asthma (self-reported)	1.0	2.0	4.7	-0.6	1.2	1.5	2.2	1.1	0.8	1.0	1.5	-2.1	2.2	0.7	0.7
Osteoporosis (self-reported)	0.2	0.2	1.0	1.0	0.0	0.7	-0.5	0.8	0.0	-0.1	-0.2	0.4	-0.2	0.1	-0.1
Osteoarthritis (self-reported)	0.8	1.1	1.7	1.0	1.2	0.2	1.1	0.9	1.2	1.2	1.3	-1.0	1.1	1.2	0.9
Medication: Aspirin	1.9	2.4	7.3	1.0	0.9	-0.0	2.5	0.9	0.8	1.1	1.9	-2.3	2.7	1.3	0.7
Medication: Gliclazide	0.6	0.7	1.9	-0.1	0.7	-0.5	1.0	0.2	1.1	1.4	1.1	-1.0	1.1	0.7	0.4
Illnesses of father: None of the above (group 1)	1.6	2.0	4.1	-1.3	-1.1	0.3	-1.6	-0.9	-1.2	-1.2	-1.7	1.5	-2.0	-1.9	-1.3
Smoking status: Current	0.6	1.0	4.8	-1.5	0.6	2.2	0.8	1.2	0.0	0.3	0.2	-1.1	0.5	0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.0	0.7	-0.4	-1.2	-1.4	-0.8	0.1	-0.7	-0.7	1.3	-1.4	-0.3	-1.0
Whole body water mass	1.5	8.6	14.3	3.8	2.1	-1.5	3.3	1.9	2.5	3.0	3.5	-3.4	3.1	3.1	3.2
Leg predicted mass (right)	2.1	11.1	16.8	3.4	2.6	-0.3	3.9	2.7	2.8	3.6	4.1	-4.1	3.8	3.5	3.3
Arm fat mass (left)	2.0	8.3	14.0	1.5	2.6	0.8	3.7	2.6	2.4	3.0	3.6	-3.5	3.6	2.8	2.9
Number of self-reported non-cancer illnesses	1.2	2.2	6.9	0.3	0.6	0.4	2.6	0.6	0.6	1.0	1.9	-2.4	2.5	0.8	-0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.8	-0.9	-0.3	0.9	-0.2	0.2	-0.8	-0.5	-0.7	0.2	0.1	-0.1	0.2
Miserableness	6.4	11.1	19.3	2.5	3.3	3.4	3.0	4.4	2.9	3.8	3.3	-3.6	3.0	3.2	3.1
Guilty feelings	1.9	2.8	5.0	-0.2	1.8	2.2	1.6	2.0	1.5	1.9	1.7	-1.7	1.9	1.3	1.5
Wears glasses or contact lenses	0.4	0.4	1.1	1.1	0.2	-0.3	0.9	0.5	0.4	0.2	0.9	-1.1	0.5	-0.3	0.3
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.4	0.2	0.5	0.1	0.8	0.4	0.5	0.2	-0.3	0.3	0.3	0.6
Hearing aid user	0.9	1.0	4.4	-0.9	0.6	2.1	1.1	1.2	0.2	0.4	0.4	-1.3	1.0	0.4	0.3
Mother’s age at death	1.9	2.4	4.5	0.4	-2.1	-1.3	-1.3	-1.6	-1.9	-1.9	-1.6	1.5	-1.1	-1.4	-1.7
Financial situation satisfaction	2.7	3.4	8.1	1.2	1.5	0.7	2.5	1.6	1.7	1.4	2.6	-2.7	2.8	0.8	0.3
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.8	0.2	1.1	1.8	1.6	1.5	0.7	0.9	1.0	-1.9	1.7	0.6	1.2
Commuting to job workplace: Public transport	2.4	2.9	7.4	-0.5	2.2	1.3	1.4	1.5	2.2	1.9	1.7	-1.5	1.1	1.5	2.7
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.5	-0.7	0.0	0.3	-0.1	-0.6	-0.7	0.1	-0.1	0.3	-1.0	-0.8
Medication: Blood pressure	0.2	0.4	4.2	-2.0	0.2	0.2	0.3	-0.7	-0.0	-0.2	0.0	0.1	0.2	-0.0	-0.4
Pain type(s) experienced in last month: Hip pain	2.7	3.5	5.5	0.5	2.0	1.1	2.3	1.6	1.7	1.6	2.1	-2.1	2.3	2.3	1.8
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.5	0.2	-0.1	-0.3	0.3	0.2	-0.1	0.1	0.4	0.2	-0.1	0.3
High cholesterol (Self-reported)	2.4	4.3	8.1	-0.4	2.0	1.9	2.8	1.8	1.7	2.1	2.1	-2.8	2.3	2.1	1.7
Medication: Bendroflumethiazide	0.7	1.0	2.0	-1.4	0.9	1.0	1.4	0.6	0.6	0.9	0.9	-1.2	1.0	1.0	0.6
Medication: Paracetamol	5.1	7.9	12.5	1.4	2.8	3.0	3.1	3.4	2.5	2.6	2.8	-3.5	2.9	2.6	2.3
Medication: Lisinopril	0.8	1.0	2.4	1.3	1.1	-0.7	0.8	0.4	1.6	0.6	1.3	-0.7	0.8	1.2	0.7
Medication: Atorvastatin	2.0	2.5	4.3	0.4	1.4	1.4	1.9	1.7	1.3	1.7	1.6	-2.1	2.0	1.7	1.0
Illnesses of father: High blood pressure	0.3	0.3	1.4	0.2	-0.3	-1.2	-0.6	-0.9	0.1	-0.1	-0.4	0.4	-1.0	0.1	-0.1
Alcohol drinker status: Never	1.9	2.3	5.5	0.5	-2.0	-1.9	-0.9	-2.2	-1.7	-1.2	-1.1	0.9	-0.8	-1.1	-2.4
Ever smoked	1.0	1.8	7.9	-1.0	1.4	2.8	0.3	2.3	1.1	0.9	0.6	-0.4	0.3	1.0	1.3
Basal metabolic rate	1.8	9.9	14.4	3.5	2.4	-1.0	3.7	2.2	2.6	3.2	3.8	-3.7	3.5	3.4	3.4
Leg fat percentage (left)	1.0	3.7	8.1	0.3	1.8	1.1	2.9	1.8	1.4	1.7	2.5	-2.4	2.7	1.5	1.5
Arm fat-free mass (left)	1.2	5.8	11.0	3.3	1.7	-1.4	2.7	1.4	2.0	2.3	2.8	-2.7	2.4	2.6	2.8
Number of operations (self-reported)	0.7	1.0	2.3	0.7	0.7	0.0	1.3	0.4	0.6	1.2	1.1	-1.5	1.4	1.3	0.2
Average weekly beer plus cider intake	0.5	0.7	2.9	-1.5	-0.1	1.7	-0.5	0.8	-0.6	-0.3	-0.7	0.4	-0.4	-0.7	0.4
Irritability	6.0	10.2	15.7	0.1	3.9	3.3	2.7	4.0	3.7	3.6	3.2	-3.1	2.4	2.7	3.7
Risk taking	2.0	2.9	7.0	-0.9	1.8	2.2	1.8	2.0	1.1	1.2	1.3	-1.8	1.5	1.4	2.6
Ever had prostate specific antigen (PSA) test	4.3	5.0	10.8	-0.2	-2.1	-3.2	-2.3	-3.3	-1.4	-1.7	-1.9	2.3	-2.3	-2.1	-2.4
Fractured/broken bones in last 5 years	1.9	2.4	4.1	0.6	1.9	1.4	1.2	1.5	1.8	2.0	1.6	-1.4	1.1	2.0	1.4
Age started oral contraceptive pill	0.5	0.7	3.6	-0.0	-0.5	-1.9	-0.4	-1.5	-0.1	-0.3	-0.3	0.5	-0.3	-0.4	-1.1
Diastolic blood pressure, automated reading	0.2	0.5	2.2	-1.5	-0.2	-0.7	0.5	-1.2	-0.3	0.6	0.1	0.1	0.7	0.2	-0.8
Ever depressed for a whole week	3.0	3.7	5.9	0.8	2.2	1.1	2.1	2.0	2.3	2.3	2.4	-2.2	1.7	1.8	1.4
Unable to work because of sickness or disability	1.1	1.4	3.4	0.3	1.2	0.3	1.4	0.6	1.1	1.8	1.3	-1.3	1.2	1.5	1.1
Commuting to job workplace: Cycle	0.3	0.3	1.3	-1.1	0.0	0.3	-0.4	-0.6	0.3	0.3	-0.4	0.3	-0.7	-0.4	-1.1
Myopia	0.4	0.5	1.8	1.3	-0.5	0.3	0.9	0.9	-0.6	-0.2	0.5	-1.0	1.0	0.1	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	5.2	1.8	0.7	2.2	0.3	2.3	0.4	0.4	0.3	-1.0	0.3	0.7	1.5
Cholesterol lowering medication	2.4	3.6	6.6	-1.0	1.9	1.3	2.6	1.2	1.8	1.8	2.1	-2.4	2.2	2.0	1.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.6	1.6	-0.1	-1.3	0.0	-0.5	0.4	-0.3	0.3	-0.1	0.1	-0.5	-1.3
Pain experienced in last month	10.5	17.5	26.0	-1.8	-4.1	-3.0	-4.8	-4.7	-4.0	-3.8	-4.9	5.1	-4.7	-4.2	-3.8
Supplements: Calcium	0.2	0.2	1.0	0.2	-0.1	1.0	-0.3	0.6	-0.4	-0.1	-0.4	0.2	-0.4	0.1	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.3	-0.7	-1.1	-0.5	-1.2	-0.5	-0.6	-0.6	0.6	-0.1	-1.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.5	0.2	0.3	-0.3	0.9	0.2	0.1	0.1	0.5	-0.6	1.2	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.4	0.1	1.1	1.3	1.8	1.4	1.0	1.2	1.5	-1.9	1.6	1.0	1.0
Heart disease (siblings)	3.6	4.4	7.9	2.3	2.5	1.0	1.7	2.6	2.8	1.9	2.6	-1.9	1.8	1.9	1.4
Alcohol drinker status: Previous	0.5	0.6	1.4	-0.5	0.4	0.0	1.2	0.1	0.3	0.7	0.9	-1.0	1.2	0.9	0.9
Pack years of smoking	1.8	2.7	4.8	0.6	1.5	1.1	1.8	1.7	1.3	2.1	1.8	-2.2	1.7	1.7	1.3
Impedance of whole body	0.5	2.7	5.5	-2.1	-0.8	0.5	-1.9	-1.0	-0.9	-1.9	-1.7	2.3	-1.8	-1.7	-1.7
Leg fat mass (left)	2.1	8.1	14.2	1.4	2.6	0.9	3.8	2.6	2.3	2.9	3.6	-3.5	3.5	2.7	2.8
Arm predicted mass (left)	1.2	6.0	10.8	3.3	1.8	-1.3	2.8	1.5	1.9	2.2	2.9	-2.8	2.5	2.6	2.8