Best TWAS P=7.7e-19 · Best GWAS P=6.74e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | B3GALT6 | 0.12 | 0.07 | enet | 14 | 0.08 | 6.9e-07 | 4.7 | -5.2 | 1.6e-07 | 0.05 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | B3GALT6 | 0.17 | 0.00 | enet | 5 | 0.00 | 5.1e-01 | 4.8 | -5.2 | 1.6e-07 | -0.01 | 0.03 | 0.06 | FALSE |
| 3 | GTEx | Artery Aorta | KLHL17 | 0.13 | -0.01 | lasso | 3 | 0.00 | 7.0e-01 | 6.1 | -5.3 | 1.3e-07 | -0.64 | 0.02 | 0.16 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | B3GALT6 | 0.19 | 0.16 | lasso | 5 | 0.12 | 2.2e-04 | 4.9 | -5.3 | 1.1e-07 | 0.05 | 0.06 | 0.05 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | MRPL20 | 0.18 | -0.01 | enet | 10 | 0.00 | 4.5e-01 | 4.9 | 5.4 | 6.3e-08 | 0.01 | 0.03 | 0.05 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | MRPL20 | 0.12 | 0.11 | lasso | 2 | 0.08 | 8.0e-07 | 5.6 | 5.7 | 1.5e-08 | -0.05 | 0.99 | 0.00 | TRUE |
| 7 | GTEx | Lung | NOC2L | 0.13 | 0.06 | lasso | 2 | 0.04 | 2.4e-04 | 5.7 | 5.5 | 3.1e-08 | 0.63 | 0.23 | 0.37 | FALSE |
| 8 | GTEx | Pancreas | MRPL20 | 0.28 | 0.21 | lasso | 2 | 0.20 | 1.2e-08 | 5.6 | 5.6 | 2.2e-08 | -0.05 | 0.91 | 0.00 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-206L10.1 | 0.35 | 0.00 | lasso | 7 | 0.00 | 2.2e-01 | 6.1 | -5.4 | 5.9e-08 | -0.45 | 0.01 | 0.04 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | B3GALT6 | 0.27 | 0.12 | enet | 17 | 0.16 | 6.7e-13 | 4.8 | -5.4 | 8.1e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | NOC2L | 0.18 | 0.16 | lasso | 2 | 0.16 | 6.3e-13 | 5.7 | 5.7 | 1.5e-08 | 0.64 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Testis | GLTPD1 | 0.24 | 0.00 | lasso | 5 | 0.01 | 1.7e-01 | 4.8 | 5.3 | 1.1e-07 | 0.52 | 0.05 | 0.07 | FALSE |
| 13 | GTEx | Thyroid | NOC2L | 0.23 | 0.17 | enet | 16 | 0.16 | 1.9e-12 | 5.7 | 5.7 | 1.4e-08 | 0.53 | 1.00 | 0.00 | FALSE |
| 14 | METSIM | Adipose | KLHL17 | 0.10 | 0.07 | bslmm | 176 | 0.06 | 4.2e-09 | 8.1 | -8.9 | 7.7e-19 | -0.96 | 0.00 | 1.00 | TRUE |
| 15 | METSIM | Adipose | MRPL20 | 0.13 | 0.11 | lasso | 5 | 0.10 | 9.7e-15 | 5.6 | 5.6 | 2.1e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | B3GALT6 | 0.04 | 0.02 | lasso | 3 | 0.02 | 7.8e-04 | 4.4 | -5.3 | 1.3e-07 | 0.03 | 0.56 | 0.01 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | MRPL20 | 0.16 | 0.15 | enet | 9 | 0.16 | 7.4e-20 | 5.2 | 5.1 | 2.8e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 18 | YFS | Blood | PUSL1 | 0.02 | 0.00 | blup | 139 | 0.01 | 8.6e-04 | 1.9 | -5.5 | 3.0e-08 | -0.09 | 0.01 | 0.06 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KLHL17 | 0.04 | 0.00 | blup | 35 | 0.01 | 7.8e-03 | 1.2 | -6.1 | 8.6e-10 | -0.54 | 0.01 | 0.16 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLEKHN1 | 0.04 | 0.03 | lasso | 4 | 0.01 | 7.8e-03 | 5.6 | -6.3 | 3.1e-10 | -0.67 | 0.04 | 0.53 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | C1orf170 | 0.07 | 0.06 | lasso | 5 | 0.07 | 1.3e-07 | 5.7 | -7.0 | 2.7e-12 | -0.81 | 0.03 | 0.97 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | KLHL17 | 0.09 | 0.05 | blup | 34 | 0.10 | 5.7e-10 | 5.7 | -6.1 | 1.4e-09 | -0.80 | 0.12 | 0.88 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | NOC2L | 0.08 | 0.07 | lasso | 6 | 0.06 | 1.3e-06 | 5.7 | 5.7 | 1.3e-08 | 0.64 | 0.84 | 0.14 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHN1 | 0.08 | 0.10 | lasso | 5 | 0.10 | 4.1e-10 | 5.7 | -6.3 | 2.2e-10 | -0.72 | 0.33 | 0.67 | FALSE |