TWAS hub - KLHL17

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1300	0.0540	7.3e-03	-0.005	NA	-0.005	NA	-0.004	9.3e-01	NA	7.3e-01	NA	7.0e-01
2	METSIM	Adipose	0.0968	0.0275	2.5e-06	0.071	0.030	0.052	0.058	0.053	7.3e-11	2.4e-05	2.5e-08	4.2e-09	1.9e-08
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0384	0.0209	4.9e-03	-0.002	0.015	0.009	NA	-0.002	7.6e-01	7.8e-03	2.8e-02	NA	8.5e-01
4	TCGA	Thyroid Carcinoma	0.0930	0.0300	3.7e-10	0.052	0.100	0.078	NA	0.076	8.7e-06	5.7e-10	4.9e-08	NA	6.7e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Heel bone mineral density (BMD) T-score, automated (right)	7.4	17.1	30.0	-4.0	-5.5	-2.9	-3.8
Heel bone mineral density (BMD) T-score, automated (left)	7.1	16.0	32.0	-3.6	-5.7	-2.3	-3.7
Alcohol intake versus 10 years previously	5.8	8.6	18.1	1.5	1.9	4.2	3.3
Heel T-Score	5.7	45.2	78.5	-5.3	-8.9	-6.1	-6.1
Financial situation satisfaction	4.8	6.0	8.6	-1.6	-2.1	-2.9	-2.9
Osteoporosis (self-reported)	4.6	5.7	9.5	2.1	3.1	1.8	2.4
Medication: Bendroflumethiazide	4.0	6.1	9.8	1.2	2.3	3.1	2.9
Cardiovascular Disease	3.7	12.1	24.2	2.4	2.9	4.9	3.2
Number of full brothers	3.7	4.6	6.6	-1.8	-1.7	-2.6	-2.4
Hypertension (Self-reported)	3.6	10.0	18.7	1.6	3.0	4.3	3.1
Medication: Blood pressure	3.5	6.7	10.2	1.3	2.9	3.2	2.6
High blood pressure	3.3	9.1	19.2	1.7	2.5	4.4	2.8
Long-standing illness, disability or infirmity	3.3	5.0	7.3	2.4	2.7	2.0	1.9
Vascular/heart problems diagnosed by doctor	3.3	9.1	19.5	-1.9	-2.3	-4.4	-2.9
Alcohol intake frequency.	3.1	7.3	17.5	1.0	1.6	4.2	2.9
Number of operations (self-reported)	3.1	4.6	11.3	-1.3	-0.6	-3.4	-2.2
Medication for cholesterol	2.9	4.4	5.8	-1.2	-2.3	-2.4	-2.2
Medication: Co-codamol	2.7	3.1	3.6	1.9	1.8	1.7	1.7
Diabetes (self-reported)	2.7	4.1	5.4	-1.9	-2.2	-1.6	-2.3
Irritability	2.7	4.6	7.5	2.7	2.4	-0.2	2.3
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	5.7	1.6	2.4	0.6	2.3
Prospective memory result	2.6	3.2	4.3	1.4	1.7	1.9	2.1
Breast cancer (self-reported)	2.6	3.1	8.1	2.8	1.5	0.4	1.3
Lung FEV1/FVC ratio	2.5	12.5	19.0	2.8	3.1	3.6	4.4
Medication: Blood pressure	2.5	4.4	7.3	1.6	1.2	2.4	2.7
Breast Cancer	2.4	5.8	10.8	1.6	2.5	2.0	3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	3.8	1.7	1.9	1.6	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	5.4	2.1	2.2	0.8	2.3
Supplements: Fish oil (including cod liver oil)	2.3	3.0	6.9	-2.6	-1.0	-1.2	-1.7
Medication: Paracetamol	2.3	3.6	4.7	2.1	1.9	1.3	2.2
Systolic Blood Pressure	2.2	11.1	13.3	3.6	3.4	2.8	3.4
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	6.0	2.5	1.8	1.0	1.1
High blood pressure (mother)	2.2	3.1	9.1	0.2	0.6	3.0	1.7
Illnesses of father: High blood pressure	2.2	2.7	4.3	1.9	0.7	1.6	2.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	5.0	1.3	2.1	1.4	2.2
Medication for pain relief, constipation, heartburn	2.0	3.3	6.4	-1.9	-1.6	-1.0	-2.5
Diastolic blood pressure, automated reading	2.0	6.1	6.8	2.3	2.5	2.5	2.6
Waist Hip Ratio (WHR)	1.9	8.7	20.2	1.2	2.1	4.5	2.9
Multivitamins +/- minerals	1.9	2.4	3.2	1.3	1.8	1.4	1.7
Loneliness, isolation	1.9	2.6	4.2	1.3	2.0	1.3	1.7
Number of self-reported non-cancer illnesses	1.9	3.2	4.5	1.0	2.1	2.0	1.9
Falls in the last year	1.8	2.4	4.3	-0.9	-0.6	-2.1	-2.1
Medication: Paracetamol	1.8	2.9	4.3	2.1	1.6	0.8	2.1
Medication: Lisinopril	1.8	2.3	4.2	1.0	1.4	1.5	2.0
Systolic blood pressure, automated reading	1.7	4.8	7.1	2.7	2.2	1.5	2.2
Severe depression (siblings)	1.7	1.9	3.3	-1.8	-1.5	-0.8	-1.3
Medication: Aspirin	1.7	2.3	3.7	1.8	0.2	1.9	1.4
Illnesses of siblings: Diabetes	1.7	2.1	4.4	-1.0	-2.1	-0.1	-1.7
Risk taking	1.7	2.4	3.6	1.6	0.6	1.8	1.9
Average weekly fortified wine intake	1.6	1.9	2.8	-1.7	-1.5	-0.9	-1.4
Lupus	1.5	2.2	4.4	-0.2	-0.7	-2.1	-2.0
Townsend deprivation index at recruitment	1.5	2.1	3.7	-0.8	-1.2	-1.6	-1.9
Number of incorrect matches in round	1.5	2.4	4.7	1.6	1.4	2.2	0.8
Pulse wave reflection index	1.5	1.8	2.8	-1.3	-0.9	-1.7	-1.4
Medication: Aspirin	1.5	2.0	3.5	1.9	0.5	1.5	1.4
Commuting to job workplace: Cycle	1.5	1.8	4.2	-0.8	-0.7	-2.0	-1.4
Alzheimer’s Disease (in father)	1.4	1.5	3.0	0.2	1.1	1.7	1.3
Neuroticism	1.4	3.5	8.3	1.4	1.2	1.4	2.9
Qualifications: College or University degree	1.4	4.5	8.8	2.6	1.2	0.9	3.0
Illnesses of father: Heart disease	1.4	1.9	3.0	-1.7	-1.3	-1.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.8	1.9	1.4	-0.1	0.7
Wears glasses or contact lenses	1.4	1.6	3.6	-0.9	-1.9	0.1	-1.5
Basal cell carcinoma (self-reported)	1.4	1.6	4.5	2.1	0.9	0.1	1.1
Average weekly spirits intake	1.3	1.6	4.0	-0.5	-2.0	-0.9	-1.1
Relative age of first facial hair	1.3	2.6	6.4	-0.3	-0.8	-2.5	-1.9
Hand grip strength (right)	1.3	3.6	5.3	1.9	2.3	1.6	1.7
Medication: Ramipril	1.3	1.7	4.4	-0.2	0.3	2.1	1.5
Noisy workplace	1.3	1.6	2.8	-1.2	-1.3	-0.9	-1.7
Overall health rating	1.3	2.9	4.3	1.2	2.1	1.6	1.8
Supplements: Calcium	1.3	1.5	2.0	0.7	1.3	1.4	1.3
Supplements: Glucosamine	1.2	1.6	3.2	-0.5	-1.6	-1.8	-0.3
Nervous feelings	1.2	2.3	3.7	0.8	1.3	1.7	1.9
Neuroticism score	1.2	2.6	5.6	1.5	1.3	0.9	2.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.7	1.7	0.2	1.0	1.5
Tinnitus: Yes, now most or all of the time	1.2	1.5	1.9	-1.3	-1.3	-0.7	-1.4
Eye problems/disorders: Glaucoma	1.2	1.5	3.1	-1.6	-0.5	-0.1	-1.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.2	-0.8	-1.5	-0.5	-1.3
Birth weight	1.1	2.4	3.9	-2.0	-0.9	-1.6	-1.5
High blood pressure (siblings)	1.1	1.6	3.8	1.0	0.5	1.9	1.2
Exposure to tobacco smoke outside home	1.1	1.4	3.9	-2.0	-0.3	0.1	-1.3
Medication: Ibuprofen	1.1	1.3	2.1	-1.3	-0.7	-1.4	-0.9
Eye problems/disorders: Cataract	1.1	1.2	3.1	0.3	1.8	0.3	1.3
Mother’s age at death	1.1	1.4	2.7	1.5	0.4	0.4	1.6
Smoking Status	1.0	2.3	2.9	-1.2	-1.5	-1.6	-1.7
Type 2 Diabetes (T2D) (2018)	1.0	1.9	2.8	-1.0	-1.4	-1.7	-1.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.4	0.8	1.0	1.0	1.6
Stomach or abdominal pain in last month	1.0	1.3	2.0	0.9	1.4	0.5	1.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.4	1.1	1.6	-1.0	0.6
Illnesses of mother	1.0	1.2	3.0	0.5	1.2	-1.7	0.1
Tense / ‘highly strung’	1.0	1.7	2.9	1.1	1.2	1.1	1.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.6	-1.4	-0.2	-1.4	-1.6
Glaucoma (self-reported)	1.0	1.2	2.2	-1.4	-0.5	-0.7	-1.5
Pulse wave peak to peak time	1.0	1.2	1.7	1.3	1.1	0.9	1.1
Age at last live birth	1.0	1.5	4.1	-0.4	-1.0	-2.0	-0.8
Smoking status: Previous	1.0	1.5	2.5	-1.6	-0.9	-0.7	-1.5
Hand grip strength (left)	0.9	2.4	5.5	0.8	2.3	1.4	1.2
Number of treatments/medications taken	0.9	1.5	3.0	0.7	1.7	0.8	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.4	1.1	1.0	1.1	1.2
Depression (self-reported)	0.9	1.0	2.6	1.6	0.5	0.6	1.0
Medication: Lansoprazole	0.9	1.1	2.3	-1.5	-0.4	-1.0	-0.8
Had major operations	0.9	1.1	2.1	-0.8	0.0	-1.5	-1.3
Diabetes diagnosed by doctor	0.9	1.5	2.0	-1.0	-1.2	-1.2	-1.4
Average weekly champagne plus white wine intake	0.9	1.2	1.8	1.3	-0.0	1.3	1.1
Guilty feelings	0.9	1.3	2.4	1.5	0.8	0.1	1.6
Ever smoked	0.9	1.5	2.3	-1.5	-1.4	-0.8	-1.1
Ever depressed for a whole week	0.9	1.2	3.6	0.3	1.9	-1.0	-0.0
Cholesterol lowering medication	0.9	1.3	2.9	0.2	1.3	1.7	0.8
Neuroticism (Nagel 2018)	0.8	1.9	4.0	1.0	0.9	1.3	2.0
Vitamin and mineral supplements	0.8	1.1	1.7	-0.7	-1.3	-1.2	-1.0
Relative age voice broke	0.8	1.2	2.0	-1.2	-0.9	-0.7	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.1	-1.4	-0.4	1.2	-0.1
Mouth/teeth dental problems	0.8	1.3	2.5	-1.4	0.2	-0.8	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.5	-0.5	0.1	-1.9	-1.1
Wheeze or whistling in the chest in last year	0.8	1.5	2.9	0.9	1.3	1.7	0.7
Heart disease (mother)	0.8	1.0	2.7	0.2	0.5	1.6	1.0
Fractured/broken bones in last 5 years	0.8	1.0	2.7	0.6	0.9	1.6	0.5
Pack years of smoking	0.8	1.2	2.8	1.2	-0.1	1.7	0.7
Worry (Nagel 2018)	0.7	1.4	2.9	0.8	0.9	1.2	1.7
Pack years adult smoking proportion	0.7	1.1	2.6	1.1	-0.0	1.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	1.3	-0.0	-0.9	0.6
Qualifications: CSEs or equivalent	0.7	0.9	1.4	-1.1	0.2	-1.0	-1.2
Medication: Atenolol	0.7	0.9	1.7	0.6	0.5	1.3	1.2
Forced vital capacity (FVC)	0.7	2.7	3.2	-1.7	-1.2	-1.8	-1.8
Fluid intelligence score	0.7	1.5	3.2	1.8	-1.0	-1.0	0.8
Pulse wave Arterial Stiffness index	0.7	0.8	0.9	-1.0	-0.8	-0.9	-0.8
Health satisfaction	0.7	1.0	2.2	0.1	1.5	0.7	1.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	0.5	-0.8	-0.8	-1.0
Medication: Levothyroxine sodium	0.6	1.1	2.1	0.0	0.0	-1.5	-1.4
Past tobacco smoking	0.6	1.2	1.6	1.3	1.1	0.6	1.3
Hearing difficulty/problems with background noise	0.6	1.0	1.4	1.2	0.9	0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	-1.1	-0.4	-1.2	-0.7
Breastfed as a baby	0.6	0.7	2.4	-0.6	1.6	-0.4	-0.0
Comparative body size at age 10	0.6	1.8	4.2	0.6	0.6	2.1	1.4
Emphysema/chronic bronchitis	0.6	0.7	1.4	1.2	0.6	0.8	0.6
Number of full sisters	0.6	0.7	2.4	-0.5	-0.1	-1.6	-0.4
Suffer from ‘nerves’	0.6	0.9	1.9	-1.4	-1.1	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	3.4	0.7	0.4	-1.8	-0.7
Commuting to job workplace: Public transport	0.6	0.7	1.5	0.3	-0.6	-1.2	-0.9
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	0.6	0.7	0.8	1.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.1	1.4	-1.1	-1.3	0.3
Ovarian Cancer	0.5	0.7	2.0	0.1	-1.4	-0.2	-0.9
Lung FVC	0.5	2.7	4.7	-2.2	-1.8	-0.6	-1.5
Hearing difficulty/problems: Yes	0.5	0.8	2.3	1.5	0.1	0.6	0.8
Medication for hormone replacement therapy	0.5	0.5	0.9	0.9	0.5	-0.6	0.8
Qualifications: None of the above	0.5	1.0	2.0	-0.8	-1.1	-0.6	-1.4
Pain all over the body in last month	0.5	0.5	1.0	-0.8	-0.5	-0.4	-1.0
Pulse rate	0.5	0.9	1.8	-1.3	-0.5	0.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.1	0.1	-0.5	-0.9	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	1.4	0.5	-0.5	1.1	1.2
Medication: Cholesterol lowering	0.5	0.7	2.6	0.1	-1.6	-0.3	-0.3
Birth weight of first child	0.5	1.0	1.5	-0.8	0.4	1.2	1.2
Headache pain in last month	0.5	0.9	1.5	0.9	1.1	-0.2	1.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	-0.1	-0.8	-1.0	-1.5
Worry too long after embarrassment	0.5	0.8	2.0	-0.0	0.5	1.1	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-1.1	0.9	-0.2	-0.6
Leg pain on walking	0.5	0.7	1.4	-0.1	-1.2	0.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.3	0.9	0.7	0.3	1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	-0.1	0.3	-1.4	-0.3
Mood swings	0.5	0.9	1.5	0.9	1.1	-0.3	1.2
Friendships satisfaction	0.5	0.7	1.2	1.1	0.5	-0.9	0.7
Qualifications: nursing, teaching	0.5	0.8	1.7	0.0	-0.3	1.3	1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	0.8	1.1	0.7	0.1
Hearing aid user	0.5	0.5	1.0	-0.6	-0.7	-0.6	-1.0
Unable to work because of sickness or disability	0.5	0.6	1.2	1.0	1.1	0.4	-0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	-0.1	0.7	0.8	1.1
BMI	0.4	2.3	3.6	1.4	0.4	1.9	1.9
Hypothyroidism (self reported)	0.4	0.8	1.7	0.6	0.6	-1.3	-0.9
Sensitivity / hurt feelings	0.4	0.6	0.8	0.9	0.9	0.6	0.8
Angina	0.4	0.5	1.4	0.2	0.0	0.8	1.2
Diabetes (father)	0.4	0.5	0.8	0.9	-0.3	0.9	0.5
Fed-up feelings	0.4	0.7	1.7	0.7	0.3	0.5	1.3
Waist circumference	0.4	1.4	3.7	0.6	0.4	1.9	1.2
Alcohol usually taken with meals	0.4	0.6	1.2	0.2	1.1	1.0	0.4
Had menopause	0.4	0.4	1.0	-0.8	-1.0	-0.3	-0.2
Heart attack	0.4	0.5	1.2	-0.1	0.7	0.7	1.1
Loud music exposure frequency	0.4	0.4	1.1	-1.1	-0.6	-0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	0.6	1.1	0.7	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	-0.8	-0.7	-1.8	-1.3
Angina (self-reported)	0.4	0.5	1.3	0.3	0.1	0.8	1.2
Medication: Omeprazole	0.4	0.5	1.3	0.5	0.4	0.4	1.1
Family relationship satisfaction	0.4	0.5	1.3	-0.1	0.2	-1.1	0.7
Mineral and other dietary supplements	0.4	0.6	1.6	1.3	0.2	0.7	0.2
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.8	-0.9	-0.3	-0.7
Average weekly beer plus cider intake	0.4	0.6	1.3	-0.4	-0.8	-0.3	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	-0.9	0.7	0.5	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.5	0.4	0.7	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.4	0.5	0.2	1.2	0.6
Reaction Time	0.3	0.5	1.4	-0.4	-0.4	-1.2	-0.5
Blood White Count	0.3	2.5	3.7	1.4	1.6	1.9	1.4
Height	0.3	5.1	10.6	-1.5	-1.7	-3.3	-2.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	0.7	1.0	-0.2	0.4
Medication: Metformin	0.3	0.5	1.4	-0.1	-0.5	-1.2	-0.5
Current tobacco smoking	0.3	0.5	1.0	-0.1	-0.6	-0.9	-1.0
Taking other prescription medications	0.3	0.5	0.9	0.7	0.9	0.2	0.8
Age when periods started (menarche)	0.3	0.6	2.2	-1.5	-0.4	0.2	-0.1
Sitting height	0.3	2.1	6.2	0.6	-0.5	-2.5	-1.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	1.0	0.6	-0.1	0.4
Illnesses of siblings	0.3	0.5	1.3	-0.6	0.2	-1.1	-0.5
Time employed in main current job	0.3	0.4	0.9	-0.2	-0.2	0.9	0.8
Father’s age at death	0.3	0.4	1.0	-0.6	-1.0	-0.1	-0.5
Worrier / anxious feelings	0.3	0.6	1.3	0.4	0.8	0.6	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.2	1.0	-0.4	0.2	1.1
Length of working week for main job	0.3	0.3	0.9	0.0	-1.0	-0.4	-0.4
Peak expiratory flow (PEF)	0.3	0.7	2.0	-1.4	-0.6	0.5	0.1
Blood clot in the leg (DVT)	0.3	0.3	1.2	0.3	1.1	-0.1	-0.3
Gout (self-reported)	0.3	0.5	1.4	-1.2	-0.4	-0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.4	-0.6	-0.4	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.9	-0.5	0.5	-0.1
Pulse rate, automated reading	0.3	0.8	1.8	0.6	1.0	1.4	-0.4
Chest pain or discomfort	0.3	0.4	0.9	0.6	0.5	0.2	1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-1.1	0.2	0.4	0.3
Supplements: Vitamin C	0.3	0.3	0.8	0.3	0.2	0.6	0.9
Knee pain experienced in last month	0.3	0.4	0.8	-0.9	-0.2	-0.9	-0.4
Average weekly red wine intake	0.3	0.4	0.9	-0.4	0.5	-0.9	-0.6
Smoking status: Current	0.3	0.4	0.8	-0.0	-0.6	-0.7	-0.9
Arm fat mass (left)	0.3	1.3	2.6	1.1	0.4	1.6	1.2
Ever taken oral contraceptive pill	0.3	0.3	1.1	1.1	0.2	-0.0	0.1
Alcohol drinker status: Never	0.3	0.3	0.6	0.2	0.5	0.8	0.6
Arm fat-free mass (left)	0.3	1.3	1.7	1.3	1.2	1.1	1.0
Age started oral contraceptive pill	0.3	0.4	1.0	0.4	-0.2	0.7	1.0
Myopia	0.3	0.4	0.6	0.7	0.8	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	0.6	0.2	0.0	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.8	-0.6	-1.0	0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	-0.3	-0.5	0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.6	0.3	1.1	0.5
Blood Red Count	0.2	1.6	5.5	-0.5	0.4	2.3	0.6
Hair Pigment	0.2	5.4	9.2	-1.9	-3.0	-2.9	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.2	-0.5	0.5	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.5	-0.2	-0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.6	0.3	1.0	0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.2	-0.7	0.1	-0.7
Body mass index (BMI)	0.2	0.8	2.4	0.5	-0.1	1.6	0.7
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.3	0.5	-0.7	-0.6
Medication: Simvastatin	0.2	0.3	0.7	-0.5	-0.4	0.8	0.4
Weight	0.2	0.8	1.4	1.2	0.3	1.0	0.9
Impedance of arm (right)	0.2	0.9	3.2	-0.0	-0.2	-1.8	-0.4
Arm fat percentage (right)	0.2	0.9	1.3	1.0	0.2	1.1	1.1
Hair/balding pattern: Pattern 3	0.2	0.4	1.2	-0.3	-0.0	1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	-1.5	-0.5	-0.7	-0.7
Happiness	0.2	0.3	1.1	0.2	0.1	-1.0	0.1
Asthma	0.2	0.4	0.7	-0.8	0.2	0.1	-0.8
Lung cancer (father)	0.2	0.2	0.5	0.6	0.7	0.1	0.1
Impedance of arm (left)	0.2	0.9	3.1	-0.1	-0.5	-1.8	-0.5
Arm fat mass (right)	0.2	0.9	1.6	0.9	0.2	1.3	1.1
Trunk predicted mass	0.2	0.9	2.1	1.4	1.1	0.4	0.5
Body fat percentage	0.2	0.6	1.2	0.5	-0.7	1.1	0.8
Leg fat percentage (right)	0.2	0.6	1.9	0.2	-0.5	1.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.4	0.7	-0.2	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.8	-0.2	0.9	-0.1	0.3
Medication: Allopurinol	0.2	0.3	0.7	-0.1	-0.7	0.8	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.7	0.1	0.9	0.1	-0.2
Whole body fat mass	0.2	1.0	1.8	1.0	-0.2	1.4	1.1
Leg fat mass (right)	0.2	0.9	1.8	0.9	0.0	1.4	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	-0.2	0.0	-0.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	0.1	0.1	0.7	0.7
Whole body fat-free mass	0.2	0.9	2.1	1.4	1.0	0.6	0.6
Arm fat percentage (left)	0.2	0.9	1.8	0.9	-0.1	1.3	1.0
Medication: Gliclazide	0.2	0.2	0.4	0.3	0.3	0.4	0.7
Whole body water mass	0.2	0.9	2.2	1.5	0.9	0.6	0.6
Miserableness	0.2	0.4	1.1	0.3	0.3	-1.1	0.3
Basal metabolic rate	0.2	0.8	2.0	1.4	0.8	0.6	0.6
Leg fat percentage (left)	0.2	0.7	2.1	-0.3	-0.8	1.4	0.4
Pain experienced in last month	0.2	0.4	0.8	-0.8	-0.1	-0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.5	0.9	0.0	-0.2
Heart disease (siblings)	0.2	0.3	0.4	-0.5	-0.3	-0.6	-0.6
Impedance of whole body	0.2	0.9	2.0	-0.9	-0.9	-1.4	-0.6
Leg fat mass (left)	0.2	0.8	1.9	0.6	-0.1	1.4	0.9
Depression (Nagel 2018)	0.1	0.2	0.2	0.3	0.5	0.3	0.5
Crohns Disease (2017)	0.1	0.3	1.0	-1.0	-0.4	0.0	0.0
Prostate Cancer	0.1	0.1	0.2	-0.5	0.1	-0.3	-0.3
Mean Putamen Volume	0.1	0.1	0.5	0.0	0.7	0.0	0.0
Neuroticism (2016)	0.1	0.2	0.4	0.0	0.5	-0.6	0.2
Blood Eosinophil Count	0.1	0.6	1.5	0.4	0.8	-1.2	0.1
Blood Platelet Count	0.1	0.9	1.4	-1.0	0.4	-1.2	-1.1
Allergy or Eczema	0.1	0.2	0.7	-0.9	-0.0	0.2	0.0
Respiratory disease	0.1	0.2	0.7	-0.0	0.9	0.4	-0.0
Chronotype (morning person)	0.1	0.3	0.7	-0.3	0.5	0.8	0.4
Supplements: Zinc	0.1	0.1	0.2	0.1	0.4	0.1	0.4
Diabetes (mother)	0.1	0.2	0.3	0.6	-0.3	-0.0	0.4
Impedance of leg (right)	0.1	0.3	0.8	-0.5	-0.3	-0.9	0.0
Leg fat-free mass (left)	0.1	0.8	2.3	1.5	0.6	0.5	0.5
Trunk fat percentage	0.1	0.5	0.6	0.4	-0.7	0.8	0.8
Maternal smoking around birth	0.1	0.1	0.4	-0.1	0.6	-0.4	-0.0
Impedance of leg (left)	0.1	0.6	1.1	-1.1	-0.5	-1.0	-0.3
Leg predicted mass (left)	0.1	0.8	2.3	1.5	0.5	0.4	0.5
Trunk fat mass	0.1	0.6	1.0	0.8	-0.4	1.0	0.9
Had other major operations	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.5
Allergy	0.1	0.2	0.5	0.2	-0.7	-0.4	0.2
Trunk fat-free mass	0.1	0.8	1.8	1.4	1.0	0.4	0.5
Number of live births	0.1	0.1	0.2	0.3	0.4	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.8	-0.9	-0.1	-0.5	-0.4
Standing height	0.1	1.1	1.9	1.4	0.8	-1.4	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.4	-0.2	0.5	0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.3	0.6	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.3	-0.2	-0.5	0.1
Medication: Amlodipine	0.1	0.2	0.4	-0.4	-0.3	0.6	-0.4
Arm fat-free mass (right)	0.1	0.4	0.8	0.8	0.4	0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	-0.2	-0.5	-0.3
Number of children fathered	0.1	0.1	0.4	0.6	-0.0	0.3	0.2
Age at first live birth	0.1	0.3	0.5	0.7	0.3	0.2	0.6
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.1	0.4	-0.2	0.3
Migraine (self-reported)	0.1	0.1	0.4	-0.2	0.6	-0.3	-0.2
Mean time to correctly identify matches	0.1	0.1	0.3	0.5	-0.0	-0.2	0.5
Arm predicted mass (right)	0.1	0.3	0.5	0.7	0.4	0.7	0.3
Comparative height size at age 10	0.1	0.5	1.0	0.7	1.0	-0.8	-0.2
Leg fat-free mass (right)	0.1	0.6	1.9	1.4	0.5	0.4	0.4
Ever had bowel cancer screening	0.1	0.1	0.2	0.0	0.5	-0.3	0.1
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.1	-0.1	-0.4	-0.6
Back pain experienced in last month	0.1	0.2	0.6	-0.3	-0.1	0.8	0.3
Asthma (self-reported)	0.1	0.2	0.4	-0.5	0.4	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.5	-0.4	0.3	0.3
Leg predicted mass (right)	0.1	0.6	1.7	1.3	0.5	0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.1	-0.3	0.5	-0.0
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.4	-0.3	0.7	-0.1
Medication: Atorvastatin	0.1	0.2	0.6	-0.1	0.7	0.0	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	0.1	0.6	0.4	0.1
Arm predicted mass (left)	0.1	0.5	0.9	0.9	0.7	0.6	0.5
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.1	0.3	0.3	0.5	-0.1	-0.5
Hip circumference	0.0	0.1	0.2	0.0	-0.3	-0.5	-0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.1	0.1	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	0.3	-0.1	-0.4	0.2

Hub : Genes

KLHL17

Models

Trait associations