[Hub]/) : Traits : Heel T-Score : ← →

chr1:5,569,491-12,429,611

Best TWAS P=1.05e-57 · Best GWAS P=4.44e-54 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DNAJC11	0.03	0.03	lasso	5	0.04	3.1e-05	8.2	9.8	1.2e-22	-0.05	0.03	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EXOSC10	0.06	0.08	lasso	2	0.07	6.8e-09	-10.2	-10.4	3.3e-25	0.04	0.01	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FBXO6	0.15	0.05	bslmm	462	0.05	3.1e-06	3.0	-6.1	1.2e-09	0.01	0.93	0.02	FALSE
4	CommonMind	Brain Pre-frontal Cortex	MTOR	0.13	0.15	lasso	4	0.15	5.6e-18	-10.0	-9.8	1.8e-22	0.03	0.02	0.98	FALSE
5	CommonMind	Brain Pre-frontal Cortex	PLEKHG5	0.09	0.06	enet	28	0.05	3.1e-07	5.3	8.0	1.5e-15	-0.07	0.79	0.20	FALSE
6	CommonMind	Brain Pre-frontal Cortex	SLC45A1	0.04	0.05	enet	9	0.02	1.8e-03	9.2	11.7	9.6e-32	-0.60	0.50	0.45	TRUE
7	GTEx	Adipose Subcutaneous	MASP2	0.10	0.06	lasso	2	0.03	8.8e-04	-7.8	-7.8	6.6e-15	0.02	0.46	0.34	FALSE
8	GTEx	Adipose Subcutaneous	RERE	0.20	0.23	lasso	2	0.24	1.7e-19	-15.4	-16.0	1.0e-57	0.98	0.01	0.99	TRUE
9	GTEx	Adipose Subcutaneous	CAMTA1	0.11	0.00	enet	26	0.00	4.6e-01	1.7	-5.3	9.9e-08	-0.03	0.09	0.24	FALSE
10	GTEx	Adipose Subcutaneous	EXOSC10	0.17	0.00	lasso	3	0.00	1.8e-01	-9.7	-8.8	2.2e-18	0.02	0.03	0.40	FALSE
11	GTEx	Adipose Subcutaneous	RP5-1115A15.1	0.14	0.07	enet	20	0.10	2.6e-08	13.3	-15.7	1.6e-55	0.79	0.08	0.92	FALSE
12	GTEx	Adipose Visceral Omentum	RERE	0.22	0.17	lasso	5	0.17	5.2e-09	13.1	-14.1	4.3e-45	0.61	0.27	0.72	FALSE
13	GTEx	Adipose Visceral Omentum	EXOSC10	0.26	0.00	lasso	7	0.03	1.3e-02	-1.7	-6.6	3.2e-11	0.02	0.03	0.70	FALSE
14	GTEx	Adipose Visceral Omentum	RP4-635E18.7	0.19	0.08	lasso	6	0.05	9.0e-04	-10.2	-9.9	3.7e-23	0.03	0.01	0.97	FALSE
15	GTEx	Brain Caudate basal ganglia	KIF1B	0.25	0.00	lasso	5	0.02	1.1e-01	-5.2	-6.0	2.4e-09	-0.04	0.05	0.19	FALSE
16	GTEx	Brain Cerebellar Hemisphere	EXOSC10	0.23	0.10	lasso	3	0.12	6.4e-04	-9.7	-10.0	1.2e-23	0.03	0.05	0.75	FALSE
17	GTEx	Brain Cerebellum	EXOSC10	0.33	0.16	lasso	6	0.18	3.8e-06	-9.9	-9.8	1.1e-22	0.03	0.05	0.94	FALSE
18	GTEx	Brain Cerebellum	RP4-635E18.7	0.17	0.17	lasso	5	0.09	1.3e-03	-9.9	-10.0	1.9e-23	0.02	0.04	0.88	FALSE
19	GTEx	Brain Cortex	RP4-635E18.7	0.17	0.05	lasso	4	0.07	6.4e-03	-10.1	-10.1	3.6e-24	0.03	0.04	0.81	FALSE
20	GTEx	Breast Mammary Tissue	RERE	0.19	0.08	enet	10	0.14	8.0e-08	-15.3	-15.6	1.2e-54	0.81	0.02	0.97	FALSE
21	GTEx	Breast Mammary Tissue	GPR153	0.13	0.03	lasso	5	0.01	1.3e-01	8.3	-8.3	9.0e-17	0.04	0.12	0.09	FALSE
22	GTEx	Breast Mammary Tissue	RP5-1115A15.1	0.10	0.07	lasso	2	0.03	7.0e-03	-15.5	-15.5	5.4e-54	1.00	0.01	0.99	FALSE
23	GTEx	Breast Mammary Tissue (Male)	RP5-1115A15.1	0.18	0.07	lasso	3	0.06	1.7e-02	5.2	-11.7	1.1e-31	0.76	0.02	0.64	FALSE
24	GTEx	Breast Mammary Tissue (Female)	THAP3	0.10	0.03	lasso	2	0.02	6.8e-02	8.3	-7.5	5.6e-14	0.05	0.07	0.06	FALSE
25	GTEx	Breast Mammary Tissue (Female)	RERE	0.14	0.12	lasso	3	0.08	2.4e-03	10.1	-10.8	2.3e-27	0.37	0.09	0.45	TRUE
26	GTEx	Breast Mammary Tissue (Female)	GPR153	0.07	-0.01	enet	3	0.00	4.3e-01	8.3	-8.4	4.1e-17	0.05	0.04	0.08	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RP5-1115A15.1	0.03	-0.01	enet	5	-0.01	5.9e-01	2.8	-6.2	4.2e-10	0.45	0.02	0.27	FALSE
28	GTEx	Cells Transformed fibroblasts	THAP3	0.19	0.11	lasso	5	0.17	1.2e-12	1.4	5.9	2.8e-09	0.01	0.44	0.56	FALSE
29	GTEx	Cells Transformed fibroblasts	ENO1	0.13	0.06	lasso	6	0.05	1.1e-04	7.3	8.4	3.8e-17	-0.29	0.90	0.04	FALSE
30	GTEx	Cells Transformed fibroblasts	UBE4B	0.09	0.00	enet	21	0.00	1.4e-01	-4.8	-5.9	3.9e-09	0.02	0.05	0.06	FALSE
31	GTEx	Cells Transformed fibroblasts	RERE	0.12	0.08	lasso	4	0.05	6.0e-05	-15.3	-15.7	1.7e-55	0.98	0.01	0.98	FALSE
32	GTEx	Colon Transverse	DFFA	0.13	0.01	enet	7	0.01	9.0e-02	6.9	-6.0	1.8e-09	-0.08	0.06	0.54	FALSE
33	GTEx	Esophagus Mucosa	KIF1B	0.10	0.00	enet	17	0.01	1.2e-01	-5.8	-7.7	1.2e-14	-0.07	0.11	0.52	TRUE
34	GTEx	Esophagus Mucosa	RERE	0.13	0.16	lasso	3	0.16	7.2e-11	13.1	-13.1	3.3e-39	0.63	1.00	0.00	FALSE
35	GTEx	Esophagus Mucosa	RP5-1115A15.1	0.06	0.06	lasso	4	0.05	3.0e-04	13.1	-12.5	7.3e-36	0.66	0.06	0.86	FALSE
36	GTEx	Heart Left Ventricle	THAP3	0.12	0.07	lasso	7	0.09	1.9e-05	-9.1	9.4	3.2e-21	0.00	0.06	0.92	FALSE
37	GTEx	Heart Left Ventricle	ENO1	0.09	0.04	lasso	4	0.00	2.0e-01	7.2	7.4	1.4e-13	-0.17	0.23	0.03	TRUE
38	GTEx	Heart Left Ventricle	SLC45A1	0.15	0.24	lasso	1	0.23	1.2e-12	6.6	6.6	4.9e-11	-0.21	1.00	0.00	FALSE
39	GTEx	Lung	ENO1	0.10	0.07	lasso	4	0.07	4.6e-06	7.0	8.1	6.0e-16	-0.18	0.96	0.00	FALSE
40	GTEx	Lung	RERE	0.07	0.05	lasso	4	0.05	2.0e-04	11.5	-11.9	1.0e-32	0.55	0.65	0.28	TRUE
41	GTEx	Lung	EXOSC10	0.11	0.07	lasso	4	0.05	1.2e-04	-9.9	-10.1	6.4e-24	0.02	0.05	0.94	FALSE
42	GTEx	Lung	RP5-1115A15.1	0.05	0.08	lasso	1	0.07	1.0e-05	13.3	-13.3	3.4e-40	0.64	0.28	0.55	FALSE
43	GTEx	Muscle Skeletal	THAP3	0.14	0.10	lasso	8	0.14	2.4e-13	1.8	6.3	2.2e-10	0.02	0.13	0.87	FALSE
44	GTEx	Muscle Skeletal	KIF1B	0.04	0.08	lasso	1	0.07	3.1e-07	-6.3	-6.3	2.8e-10	-0.05	0.98	0.01	FALSE
45	GTEx	Muscle Skeletal	SLC45A1	0.08	0.08	lasso	4	0.06	8.0e-07	7.2	7.1	1.1e-12	-0.22	0.96	0.00	FALSE
46	GTEx	Muscle Skeletal	RP5-1115A15.1	0.09	0.07	enet	10	0.06	1.5e-06	13.1	-7.7	1.2e-14	0.29	0.99	0.00	FALSE
47	GTEx	Nerve Tibial	MASP2	0.14	0.07	lasso	5	0.09	1.2e-06	-7.8	-7.2	8.7e-13	0.03	0.44	0.44	FALSE
48	GTEx	Nerve Tibial	KIF1B	0.10	0.07	lasso	6	0.04	8.5e-04	-6.0	-6.3	2.9e-10	-0.07	0.92	0.02	FALSE
49	GTEx	Nerve Tibial	RERE	0.12	0.09	enet	16	0.11	5.6e-08	-14.9	-15.6	5.6e-55	0.92	0.01	0.99	FALSE
50	GTEx	Pancreas	RERE	0.11	0.12	lasso	4	0.07	5.9e-04	-15.4	-15.6	1.5e-54	0.97	0.01	0.96	FALSE
51	GTEx	Prostate	RP1-120G22.11	0.41	-0.01	enet	36	0.02	9.4e-02	4.6	5.3	8.9e-08	0.03	0.05	0.18	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	RERE	0.12	0.05	lasso	4	0.05	1.3e-03	11.1	-11.3	7.6e-30	0.39	0.57	0.03	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	RP5-1115A15.1	0.08	0.04	enet	8	0.04	3.0e-03	11.6	-12.2	3.4e-34	0.56	0.40	0.05	FALSE
54	GTEx	Skin Sun Exposed Lower leg	RERE	0.14	0.05	lasso	8	0.08	4.3e-07	13.1	-12.0	2.9e-33	0.51	0.98	0.01	FALSE
55	GTEx	Skin Sun Exposed Lower leg	RP5-1115A15.1	0.07	0.03	enet	13	0.03	1.5e-03	13.1	-11.5	8.3e-31	0.53	0.40	0.35	FALSE
56	GTEx	Stomach	RP4-635E18.7	0.13	0.06	enet	25	0.03	8.8e-03	-10.0	-5.8	6.2e-09	0.03	0.04	0.86	FALSE
57	GTEx	Testis	THAP3	0.22	0.19	lasso	5	0.22	3.1e-10	8.3	10.0	1.7e-23	-0.06	0.33	0.67	FALSE
58	GTEx	Thyroid	KIF1B	0.13	0.14	lasso	5	0.16	5.3e-12	-6.3	-6.4	1.9e-10	-0.06	1.00	0.00	FALSE
59	GTEx	Thyroid	RP4-635E18.7	0.07	0.02	lasso	2	0.01	5.5e-02	-9.9	-9.4	3.4e-21	0.02	0.03	0.84	FALSE
60	GTEx	Thyroid	RP5-1115A15.1	0.09	0.12	lasso	2	0.09	1.5e-07	13.3	-13.8	2.1e-43	0.67	0.91	0.09	FALSE
61	GTEx	Whole Blood	RERE	0.19	0.15	lasso	4	0.13	2.7e-12	13.1	-13.7	1.8e-42	0.67	0.97	0.03	FALSE
62	GTEx	Whole Blood	MTOR	0.16	0.06	enet	18	0.07	5.1e-07	-9.5	-7.8	5.3e-15	0.04	0.65	0.34	FALSE
63	METSIM	Adipose	EXOSC10	0.05	0.06	lasso	1	0.05	3.5e-08	-9.3	-9.3	1.7e-20	0.01	0.02	0.98	FALSE
64	METSIM	Adipose	MTOR	0.04	0.02	bslmm	434	0.02	1.5e-04	-10.0	-9.5	1.4e-21	-0.01	0.03	0.96	FALSE
65	METSIM	Adipose	RERE	0.08	0.12	lasso	17	0.13	1.8e-19	-15.5	-15.7	1.8e-55	0.89	0.01	0.99	FALSE
66	NTR	Blood	RERE	0.04	0.04	lasso	8	0.03	2.0e-11	11.6	-13.4	5.5e-41	0.65	1.00	0.00	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	KIF1B	0.06	0.08	bslmm	401	0.07	2.1e-09	-6.5	-6.2	6.4e-10	-0.05	0.99	0.01	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	RERE	0.15	0.15	lasso	7	0.15	1.5e-18	-15.3	-15.9	3.6e-57	0.96	0.02	0.98	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	KLHL21	0.04	0.03	lasso	3	0.02	7.8e-04	7.6	-7.8	6.8e-15	0.08	0.74	0.03	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	EXOSC10	0.06	0.06	lasso	2	0.06	4.9e-08	-10.2	-10.3	7.7e-25	0.04	0.01	0.99	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	MTOR	0.07	0.05	bslmm	423	0.04	2.0e-06	-10.0	-10.8	3.8e-27	0.02	0.04	0.96	TRUE
72	ROSMAP	Brain Pre-frontal Cortex	RP4-635E18.7	0.23	0.09	enet	24	0.24	3.8e-30	-6.8	-7.1	1.2e-12	0.00	0.02	0.98	FALSE
73	YFS	Blood	ENO1	0.07	0.06	lasso	7	0.06	5.1e-19	-8.9	9.7	3.9e-22	-0.47	1.00	0.00	FALSE
74	YFS	Blood	PHF13	0.04	0.04	bslmm	425	0.05	3.0e-15	8.1	-6.5	7.5e-11	0.08	1.00	0.00	FALSE
75	YFS	Blood	RERE	0.09	0.15	lasso	4	0.16	5.7e-49	13.5	-14.7	4.6e-49	0.73	1.00	0.00	FALSE
76	YFS	Blood	SPSB1	0.03	0.03	bslmm	425	0.03	1.5e-09	-5.4	-6.1	1.2e-09	0.08	1.00	0.00	TRUE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	RERE	0.02	0.03	lasso	2	0.03	4.7e-07	13.5	-13.5	2.7e-41	0.62	0.89	0.06	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	THAP3	0.04	0.04	blup	52	0.05	4.5e-10	1.4	5.6	2.0e-08	0.02	0.51	0.49	FALSE
79	The Cancer Genome Atlas	Esophageal Carcinoma	RERE	0.10	0.07	blup	154	0.06	5.2e-03	9.0	-10.7	1.2e-26	0.39	0.08	0.05	TRUE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	PEX14	0.12	0.00	blup	123	0.05	9.9e-03	-4.8	6.4	2.1e-10	0.06	0.05	0.14	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	THAP3	0.06	0.02	blup	51	0.03	2.8e-04	-9.6	8.0	1.2e-15	0.00	0.01	0.97	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTOR	0.02	0.02	blup	54	0.02	5.4e-03	-9.9	-10.0	9.8e-24	0.03	0.05	0.73	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	THAP3	0.10	0.07	blup	51	0.08	4.0e-05	1.7	6.9	6.2e-12	-0.05	0.08	0.66	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNAJC11	0.02	0.00	blup	74	0.01	9.1e-03	8.3	10.2	2.6e-24	-0.05	0.03	0.52	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTOR	0.03	0.01	blup	54	0.02	5.9e-03	-10.0	-9.7	4.0e-22	0.02	0.03	0.71	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	NOL9	0.08	0.00	blup	44	0.01	4.9e-02	2.2	5.8	6.5e-09	0.01	0.01	0.23	FALSE
87	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MASP2	0.05	0.03	blup	30	0.04	6.0e-03	-5.4	8.3	8.8e-17	-0.02	0.02	0.55	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	THAP3	0.08	0.04	enet	7	0.04	3.7e-03	-9.8	8.1	5.7e-16	-0.01	0.02	0.88	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	RERE	0.06	0.01	blup	154	0.03	2.7e-04	13.3	-10.4	1.5e-25	0.38	0.40	0.07	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RERE	0.04	0.02	blup	154	0.02	8.7e-04	11.4	-9.9	4.2e-23	0.36	0.27	0.03	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	THAP3	0.05	0.04	blup	51	0.05	4.4e-06	-9.6	10.3	5.6e-25	-0.01	0.01	0.99	TRUE
92	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RERE	0.22	0.04	lasso	10	0.08	4.1e-04	13.1	-15.6	8.6e-55	0.85	0.03	0.92	TRUE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	PEX14	0.07	0.00	enet	19	0.01	5.2e-02	6.9	-5.3	1.1e-07	-0.07	0.03	0.69	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	RERE	0.04	0.01	blup	154	0.01	3.1e-02	7.2	-7.2	8.1e-13	0.17	0.06	0.04	FALSE
95	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KLHL21	0.11	0.12	lasso	2	0.09	5.4e-04	8.1	8.1	6.3e-16	-0.05	0.22	0.34	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	THAP3	0.06	0.03	lasso	4	0.05	1.1e-05	1.4	5.7	1.4e-08	0.02	0.10	0.87	FALSE
97	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RERE	0.12	0.01	enet	10	0.03	4.6e-02	10.7	-9.1	1.3e-19	0.37	0.08	0.11	FALSE