Best TWAS P=6.06e-13 · Best GWAS P=1.64e-40 conditioned to 2.04e-35
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RIOK1 | 0.05 | 0.04 | enet | 14 | 0.05 | 2.6e-06 | -4.2 | 5.3 | 1.1e-07 | 0.00 | 0.88 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SSR1 | 0.14 | 0.10 | lasso | 5 | 0.12 | 4.2e-09 | 3.7 | -6.2 | 7.7e-10 | -0.03 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-69L16.4 | 0.15 | 0.06 | lasso | 4 | 0.07 | 4.6e-06 | 3.7 | -5.4 | 6.7e-08 | -0.03 | 0.94 | 0.00 | TRUE |
| 4 | GTEx | Esophagus Mucosa | SSR1 | 0.16 | 0.04 | lasso | 3 | 0.04 | 8.2e-04 | 7.6 | 7.2 | 6.1e-13 | 0.08 | 0.34 | 0.02 | TRUE |
| 5 | GTEx | Spleen | DSP | 0.42 | 0.16 | enet | 33 | 0.09 | 3.0e-03 | -2.6 | 5.1 | 2.9e-07 | 0.05 | 0.62 | 0.04 | FALSE |
| 6 | GTEx | Whole Blood | RIOK1 | 0.08 | 0.06 | enet | 26 | 0.05 | 1.6e-05 | -4.4 | 6.0 | 1.5e-09 | 0.05 | 0.90 | 0.01 | TRUE |