Best TWAS P=2.15e-12 · Best GWAS P=3.85e-15 conditioned to 1.21e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FANCE | 0.03 | 0.02 | bslmm | 420 | 0.01 | 1.7e-02 | -5.8 | -6.0 | 1.7e-09 | 0.14 | 0.37 | 0.04 | FALSE |
| 2 | GTEx | Artery Aorta | RPL10A | 0.20 | 0.12 | lasso | 5 | 0.11 | 8.8e-07 | -6.1 | -5.8 | 5.0e-09 | -0.03 | 0.95 | 0.01 | FALSE |
| 3 | GTEx | Artery Tibial | RPL10A | 0.11 | 0.08 | lasso | 2 | 0.09 | 1.5e-07 | -6.0 | -5.5 | 4.7e-08 | -0.05 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | NUDT3 | 0.11 | 0.03 | lasso | 3 | 0.02 | 9.2e-03 | -5.5 | 5.5 | 4.9e-08 | -0.59 | 0.14 | 0.45 | FALSE |
| 5 | GTEx | Colon Transverse | RPL10A | 0.12 | 0.05 | lasso | 4 | 0.05 | 2.5e-03 | -6.0 | -5.2 | 1.5e-07 | -0.03 | 0.27 | 0.07 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RPL10A | 0.31 | 0.19 | lasso | 5 | 0.18 | 4.6e-11 | -6.1 | -6.1 | 8.6e-10 | 0.01 | 0.99 | 0.01 | FALSE |
| 7 | GTEx | Muscle Skeletal | RPL10A | 0.10 | 0.05 | enet | 17 | 0.04 | 3.9e-05 | -6.2 | -5.9 | 4.0e-09 | -0.02 | 0.72 | 0.02 | FALSE |
| 8 | GTEx | Nerve Tibial | RPL10A | 0.14 | 0.12 | lasso | 3 | 0.12 | 9.7e-09 | -6.1 | -6.5 | 1.1e-10 | 0.01 | 0.98 | 0.01 | FALSE |
| 9 | METSIM | Adipose | RPL10A | 0.18 | 0.13 | lasso | 15 | 0.13 | 3.4e-19 | -6.1 | -6.2 | 6.0e-10 | 0.01 | 0.19 | 0.81 | FALSE |
| 10 | NTR | Blood | ZNF76 | 0.01 | 0.00 | blup | 424 | 0.00 | 3.8e-02 | -5.3 | 6.2 | 4.2e-10 | -0.18 | 0.23 | 0.08 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | DEF6 | 0.04 | 0.02 | bslmm | 421 | 0.02 | 1.8e-03 | -4.8 | 5.6 | 2.3e-08 | -0.23 | 0.79 | 0.02 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | ZNF76 | 0.04 | 0.00 | blup | 424 | 0.02 | 2.1e-03 | -4.7 | 7.0 | 2.1e-12 | -0.29 | 0.43 | 0.21 | TRUE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | RPL10A | 0.30 | 0.18 | bslmm | 409 | 0.19 | 2.6e-24 | -6.0 | -5.2 | 2.5e-07 | 0.15 | 0.99 | 0.01 | FALSE |
| 14 | YFS | Blood | RPL10A | 0.24 | 0.11 | lasso | 11 | 0.13 | 4.4e-39 | -6.1 | -5.5 | 4.3e-08 | 0.00 | 0.94 | 0.06 | FALSE |
| 15 | YFS | Blood | RPS10 | 0.05 | 0.05 | bslmm | 353 | 0.05 | 2.2e-16 | -4.8 | -5.2 | 2.6e-07 | 0.65 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPL10A | 0.03 | 0.00 | blup | 54 | 0.02 | 6.0e-03 | -4.5 | -5.3 | 1.0e-07 | 0.05 | 0.05 | 0.04 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL10A | 0.03 | 0.00 | blup | 55 | 0.01 | 1.4e-03 | -6.1 | -5.8 | 8.3e-09 | 0.09 | 0.05 | 0.04 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL10A | 0.07 | 0.07 | lasso | 2 | 0.06 | 9.9e-08 | -6.0 | -5.8 | 5.8e-09 | -0.02 | 0.82 | 0.18 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DEF6 | 0.04 | 0.01 | blup | 50 | 0.03 | 6.2e-04 | -4.7 | 5.6 | 2.3e-08 | -0.25 | 0.18 | 0.14 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL10A | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.8e-03 | -5.8 | -5.8 | 7.0e-09 | 0.00 | 0.08 | 0.09 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TCP11 | 0.03 | 0.03 | lasso | 3 | 0.04 | 3.8e-05 | -5.2 | -5.3 | 1.3e-07 | 0.16 | 0.26 | 0.09 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PPARD | 0.12 | 0.10 | lasso | 5 | 0.05 | 5.3e-03 | -3.3 | 5.2 | 1.8e-07 | -0.39 | 0.03 | 0.91 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL10A | 0.05 | 0.07 | enet | 4 | 0.04 | 1.2e-04 | -6.1 | -5.7 | 1.5e-08 | -0.02 | 0.61 | 0.23 | FALSE |