TWAS hub - DSP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.3296	0.0632	6.9e-06	0.233	NA	0.222	NA	0.229	8.2e-18	NA	6.5e-17	NA	1.9e-17
2	GTEx	Nerve Tibial	0.2041	0.0578	2.2e-05	0.072	NA	0.043	NA	0.037	8.3e-06	NA	5.0e-04	NA	1.2e-03
3	GTEx	Spleen	0.4190	0.1010	7.3e-05	0.159	NA	0.087	NA	0.046	7.1e-05	NA	3.0e-03	NA	2.5e-02
4	METSIM	Adipose	0.0784	0.0209	8.5e-08	0.070	0.047	0.056	0.054	0.058	9.9e-11	1.2e-07	7.1e-09	1.7e-08	4.0e-09
5	NTR	Blood	0.0852	0.0149	0.0e+00	0.127	0.101	0.121	0.123	0.124	1.3e-38	9.0e-31	4.9e-37	1.9e-37	7.0e-38
6	TCGA	Prostate Adenocarcinoma	0.0522	0.0237	1.5e-03	0.013	0.025	0.011	NA	0.016	1.5e-02	1.1e-03	2.3e-02	NA	8.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate, automated reading	5.1	16.4	71.9	3.6	2.2	1.1	1.9	1.9	8.5
Lung FEV1/FVC ratio	4.7	23.9	118.8	-10.9	0.2	-2.9	-2.3	-2.3	-2.4
Chronotype (morning person)	3.6	8.4	11.4	-3.1	-2.6	-3.4	-3.2	-3.1	-1.7
Commuting to job workplace: Walk	3.5	3.8	5.7	0.2	-1.6	-2.1	-2.4	-2.3	2.1
Ever taken oral contraceptive pill	3.5	3.9	8.2	-0.3	2.9	2.4	2.1	2.0	-0.9
Medication: Ramipril	3.3	4.3	15.2	-3.1	0.1	0.8	0.2	0.2	-3.9
Lung FVC	3.2	16.3	34.6	5.9	3.8	2.9	3.7	3.7	3.5
Pain all over the body in last month	3.2	3.5	8.2	-0.6	2.9	2.5	1.8	1.7	0.4
Pulse rate	2.8	4.8	18.4	2.6	0.5	0.4	1.2	1.3	4.3
Supplements: Fish oil (including cod liver oil)	2.6	3.4	5.7	-0.1	2.4	1.6	2.3	2.3	-1.0
Hearing difficulty/problems: Yes	2.5	3.8	6.4	1.5	-2.5	-1.9	-2.3	-2.3	0.3
Coronary Artery Disease (CAD)	2.3	2.7	3.6	-1.6	-1.8	-1.8	-1.9	-1.8	-0.3
Heart attack	2.3	2.9	5.8	-0.0	-1.6	-1.2	-2.0	-1.9	2.4
Number of full brothers	2.3	2.9	6.4	0.5	-2.5	-1.6	-2.0	-2.0	-0.5
Financial difficulties in last 2 years	2.1	2.8	5.3	1.0	1.2	2.3	1.9	1.9	1.2
Hearing aid user	2.0	2.3	3.5	1.5	-1.9	-1.6	-1.5	-1.6	0.8
High cholesterol (Self-reported)	2.0	3.6	6.8	0.5	-2.6	-1.9	-2.3	-2.3	0.5
Average weekly spirits intake	1.9	2.3	5.7	-1.9	1.3	1.3	0.8	0.6	-2.4
Supplements: Zinc	1.9	2.1	3.5	-1.3	-0.8	-1.2	-1.8	-1.9	-1.3
Exposure to tobacco smoke at home	1.9	2.2	3.5	-0.4	-1.6	-1.9	-1.8	-1.8	0.7
Average weekly red wine intake	1.9	2.7	7.2	2.7	1.6	1.1	0.7	0.6	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.8	1.0	0.5	1.9	1.8	2.0	-0.3
Diabetes diagnosed by doctor	1.8	2.9	6.2	-0.7	1.6	2.5	1.6	1.4	-1.9
Medication: Paracetamol	1.8	2.8	4.0	-1.2	1.6	2.0	1.9	1.9	-1.3
Heart attack/myocardial infarction (self-reported)	1.8	2.4	5.2	0.1	-1.4	-1.1	-1.8	-1.7	2.3
Medication: Paracetamol	1.7	2.8	3.8	-1.0	1.5	1.9	1.9	1.9	-1.6
Number of children fathered	1.7	2.0	3.8	0.5	-2.0	-0.8	-1.8	-1.9	-0.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	4.7	-0.3	-1.5	-2.2	-1.5	-1.6	0.7
Rheumatoid Arthritis	1.6	2.2	4.2	-1.3	0.7	2.1	1.4	1.4	-1.7
Migraine (self-reported)	1.6	2.0	8.5	1.0	-0.4	-1.4	-0.5	-0.4	2.9
Breast cancer (self-reported)	1.6	1.9	5.0	0.6	0.6	2.2	1.7	1.6	-0.5
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.1	-1.1	1.5	2.1	1.4	1.3	-2.3
Forced vital capacity (FVC)	1.5	5.6	13.8	3.7	2.0	1.6	1.7	1.6	2.8
LDL Cholesterol	1.4	2.2	9.0	-3.0	-0.0	-0.1	-0.8	-0.8	-1.8
Length of working week for main job	1.4	1.6	3.5	-1.9	-0.9	-0.2	-1.1	-1.2	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	7.8	2.2	-0.3	-0.5	-0.3	-0.3	2.8
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.0	0.3	2.0	1.0	1.4	1.3	1.0
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.3	-1.2	-1.5	-1.5	-1.5	-1.5	0.1
Basal cell carcinoma (self-reported)	1.4	1.7	2.3	-1.3	-1.1	-1.5	-1.3	-1.3	1.2
Prostate Cancer	1.3	1.8	2.6	-0.4	1.5	1.6	1.5	1.6	-0.9
Heel T-Score	1.3	10.1	26.3	0.2	2.9	5.1	2.8	2.7	-3.3
Diabetes (self-reported)	1.3	2.0	4.4	0.3	1.6	2.1	1.5	1.3	-1.0
Comparative body size at age 10	1.3	3.5	4.2	-1.9	1.8	1.7	2.0	2.0	-1.8
Age at last live birth	1.3	1.8	3.8	-0.3	-1.4	-1.9	-1.5	-1.5	0.8
Alzheimer’s Disease (in mother)	1.2	1.4	4.2	-1.1	0.0	1.2	0.9	0.8	-2.1
Pulse wave reflection index	1.2	1.5	4.1	-1.3	0.4	1.4	0.7	0.7	-2.0
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.6	-0.2	1.0	1.8	1.9	1.8	-0.0
Mother’s age at death	1.2	1.4	6.7	-1.3	-0.4	0.3	0.1	0.1	-2.6
Relative age of first facial hair	1.1	2.3	10.5	1.3	-0.4	-0.7	-0.8	-0.8	3.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.0	2.0	0.3	0.0	0.5	0.6	1.9
Ever had hysterectomy (womb removed)	1.1	1.3	5.7	2.4	0.1	0.8	0.8	0.8	-0.3
Medication for hormone replacement therapy	1.1	1.2	2.0	1.4	1.1	1.4	1.0	1.0	0.2
Relative age voice broke	1.1	1.6	4.0	-0.0	1.2	1.3	1.1	1.2	2.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.7	0.8	1.1	0.5	1.6	1.6	0.5
Diabetes (father)	1.0	1.3	4.8	-0.9	0.7	1.2	0.2	0.1	-2.2
Chronic bronchitis/emphysema (father)	1.0	1.2	2.2	0.4	1.5	1.1	1.3	1.3	0.4
Forced vital capacity (FVC), Best measure	1.0	3.6	12.0	3.5	1.7	0.9	0.8	0.8	2.2
Emphysema/chronic bronchitis	1.0	1.1	1.9	-0.8	-1.4	-0.2	-1.0	-1.1	1.3
Long-standing illness, disability or infirmity	1.0	1.5	3.5	-0.8	0.3	1.9	1.5	1.5	-0.7
Ever had bowel cancer screening	1.0	1.1	2.5	0.0	-0.6	-1.6	-1.1	-1.1	1.2
Mineral and other dietary supplements	1.0	1.3	3.1	0.6	-1.8	-1.2	-1.1	-1.1	0.8
Alcohol drinker status: Previous	1.0	1.1	3.1	-0.8	-1.8	0.3	-0.3	-0.3	-1.6
Major Depression (MDD)	0.9	1.1	5.3	-0.6	-0.0	-0.6	-0.6	-0.5	2.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	2.8	1.4	-1.7	-1.5	-1.6	-1.6	1.0
Bipolar Disorder (2011)	0.9	0.9	2.2	0.0	0.5	0.7	1.5	1.5	0.2
Primary Biliary Cirrhosis	0.9	1.3	5.1	0.6	0.2	-0.9	-0.9	-0.9	2.3
Systolic blood pressure, automated reading	0.9	2.5	8.6	-1.7	-1.1	-0.9	-0.9	-0.9	-2.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.5	1.9	0.7	1.1	0.4	0.4	0.8
Stomach or abdominal pain in last month	0.9	1.1	4.5	0.2	0.6	0.4	0.8	0.8	2.1
Hearing difficulty/problems with background noise	0.9	1.4	2.1	1.1	-1.1	-1.5	-1.2	-1.1	1.2
Fluid intelligence score	0.9	1.8	2.6	1.2	-1.6	-0.8	-1.6	-1.6	1.2
Breastfed as a baby	0.9	1.1	1.8	1.4	-0.5	1.2	0.8	0.6	-1.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.6	-1.1	-1.1	-0.0	-1.2	-1.2	-0.8
Medication: Amlodipine	0.9	1.2	2.6	-1.2	-0.2	1.3	0.9	0.8	-1.6
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.1	0.2	1.3	1.4	1.3	1.2	-0.5
Medication: Blood pressure	0.9	1.6	4.9	-2.2	0.1	0.5	0.8	0.7	-1.8
Number of full sisters	0.9	1.1	1.7	0.6	1.1	0.9	1.2	1.3	-1.0
Leg pain on walking	0.9	1.1	3.3	-1.8	0.3	1.0	0.3	0.2	-1.6
Loneliness, isolation	0.9	1.3	3.9	-2.0	-0.7	-0.9	-0.9	-0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	0.5	1.5	1.0	1.1	1.2	0.6
Osteoporosis (self-reported)	0.9	1.2	2.8	1.1	-1.7	-0.7	-1.1	-1.1	0.4
Cholesterol lowering medication	0.9	1.3	5.2	2.3	-1.4	0.4	0.1	0.1	0.5
Crohns Disease (2012)	0.8	1.4	2.6	-0.6	-1.6	-1.5	-1.3	-1.2	-0.0
HbA1C	0.8	0.9	3.3	1.8	-0.0	-0.1	-0.1	-0.2	1.4
Medication: Metformin	0.8	1.1	2.7	-1.5	-0.2	1.1	0.5	0.4	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.7	-0.5	1.4	1.8	0.9	0.9	-1.9
Qualifications: CSEs or equivalent	0.8	1.0	2.9	-1.7	-0.8	-0.1	-0.1	-0.0	-1.6
Illnesses of siblings: Diabetes	0.8	0.9	4.1	-0.6	-0.7	-0.4	-0.4	-0.5	-2.0
Unable to work because of sickness or disability	0.8	1.1	4.1	0.3	0.4	2.0	1.1	0.9	0.3
Fasting Glucose	0.7	0.8	2.0	-0.4	1.1	1.4	1.0	0.8	-0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	1.1	-0.4	-1.1	-1.2	-1.0	0.5
Serious illness, injury or assault to yourself	0.7	0.9	2.6	-0.1	0.6	1.6	1.1	1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.4	-0.1	1.4	1.9	1.2	1.2	-1.3
Alcohol intake versus 10 years previously	0.7	1.1	2.4	0.7	-0.7	-0.9	-1.6	-1.5	-0.4
Father’s age at death	0.7	0.9	1.3	-0.9	1.0	0.5	1.1	0.9	-1.2
Medication: Cholesterol lowering	0.7	1.0	1.8	0.0	-0.8	-1.4	-1.2	-1.2	0.9
Health satisfaction	0.7	0.9	3.5	-1.9	-0.2	-0.3	0.0	0.0	-1.3
Medication: Seretide 50 evohaler	0.7	0.8	2.3	1.5	-0.1	1.1	0.7	0.7	-0.5
Chest pain or discomfort	0.7	1.0	3.9	-2.0	-0.8	0.1	-0.3	-0.2	-1.0
Had major operations	0.7	0.8	1.1	-1.0	1.0	0.2	1.0	1.1	-0.6
Eye problems/disorders: Cataract	0.7	0.9	4.9	2.2	0.3	-0.1	0.3	0.3	-0.2
Asthma (self-reported)	0.7	1.4	2.1	-0.3	0.9	1.5	1.4	1.4	1.1
Number of self-reported non-cancer illnesses	0.7	1.3	5.3	0.5	-2.3	-0.6	-0.6	-0.5	-1.0
Average weekly champagne plus white wine intake	0.7	1.0	2.2	-1.1	-0.2	-0.5	-1.4	-1.5	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.9	-0.7	-0.5	0.2	0.7	0.8	-1.7
Illnesses of father: High blood pressure	0.7	0.9	1.7	-0.7	-1.3	-0.9	-1.0	-0.9	-0.8
Mean Putamen Volume	0.6	0.7	1.8	-0.6	-1.4	-0.1	-0.8	-1.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.9	0.3	0.2	1.7	0.9	0.9	0.4
Townsend deprivation index at recruitment	0.6	0.8	4.6	-0.1	0.7	-0.3	-0.1	0.0	2.1
Age when periods started (menarche)	0.6	1.4	4.5	2.1	-0.2	0.2	-0.0	0.0	2.0
High blood pressure (mother)	0.6	0.8	1.8	-0.5	-1.3	-1.1	-0.8	-0.8	-0.5
Medication: Simvastatin	0.6	0.8	2.1	0.7	-1.5	-0.4	-1.0	-1.0	-0.3
Illnesses of siblings	0.6	0.8	3.8	0.3	-0.4	-0.8	-0.4	-0.4	2.0
Time employed in main current job	0.6	0.7	2.7	-1.0	-0.1	-0.2	0.5	0.5	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.7	-1.9	-0.6	0.0	-0.4	-0.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.3	1.4	-0.1	0.1	0.2	0.2	1.5
Gout (self-reported)	0.6	0.8	1.6	0.5	-1.3	-0.9	-1.1	-1.0	0.2
Medication: Aspirin	0.6	0.9	1.5	-1.2	-0.3	1.2	0.6	0.5	-1.2
Medication for cholesterol	0.6	1.0	3.4	-1.8	0.7	-1.3	-0.4	-0.3	-0.1
Smoking status: Current	0.6	0.9	2.2	-0.4	-0.8	-1.5	-1.0	-0.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.9	0.7	0.8	-0.7	0.1	0.1	2.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	-1.3	0.3	-0.1	0.3	0.3	-1.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	1.6	-0.5	0.6	-0.1	-0.2	-0.8
Ovarian Cancer	0.5	0.7	2.9	-1.7	-0.2	-0.6	-0.5	-0.4	-0.5
Triglycerides	0.5	0.8	3.9	-0.6	0.1	0.6	0.2	0.2	-2.0
Ulcerative Colitis	0.5	0.7	1.4	-1.2	-1.0	-1.0	-0.1	0.2	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.0	1.0	0.8	1.0	0.7	0.5	-0.4
Vitamin and mineral supplements	0.5	0.7	2.4	1.5	-0.0	0.4	0.8	0.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	3.1	-0.6	-0.1	-0.3	-0.2	-0.2	1.7
Allergy	0.5	1.1	1.9	0.0	-1.3	-1.4	-1.2	-1.2	0.4
Hair/balding pattern: Pattern 3	0.5	0.7	3.8	-0.6	-0.3	0.1	-0.1	-0.1	-1.9
Number of live births	0.5	0.7	1.7	0.6	0.3	0.6	1.3	1.3	0.3
Depression (self-reported)	0.5	0.6	1.9	1.2	-0.4	-0.1	0.3	0.2	1.4
Glaucoma (self-reported)	0.5	0.6	1.4	-1.1	-0.9	-0.4	-0.4	-0.4	-1.2
Eye problems/disorders: None of the above	0.5	0.6	1.2	-0.7	0.2	0.6	0.8	1.0	1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	3.2	0.8	-0.2	-0.8	-0.7	-0.6	1.8
Medication: Ibuprofen	0.5	0.6	3.0	0.7	0.2	0.3	0.1	0.1	1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.8	0.3	0.6	0.9	0.8	0.7	-0.9
Knee pain experienced in last month	0.5	0.8	1.6	-0.6	-1.2	-1.3	-0.8	-0.7	0.5
Osteoarthritis (self-reported)	0.5	0.6	1.2	0.8	-1.1	-0.4	-0.6	-0.6	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-1.1	-1.3	-0.2	-0.7	-0.7	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.4	-0.3	1.0	1.2	1.1	1.0	0.1
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.2	0.9	1.3	0.8	0.8	0.4
Supplements: Calcium	0.5	0.6	3.4	0.1	-0.4	0.1	-0.2	-0.1	-1.8
Bipolar Disorder (2018)	0.4	0.6	1.7	-1.0	-0.9	0.3	-0.3	-0.3	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.3	2.3	-0.8	-0.9	-0.5	-0.6	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	0.9	0.9	1.0	0.7	0.7	-0.1
Lupus	0.4	0.6	1.3	-0.1	-0.8	-1.1	-0.8	-0.9	0.5
Systolic Blood Pressure	0.4	2.0	3.5	-0.7	-1.6	-1.5	-1.3	-1.3	-1.9
Respiratory disease	0.4	0.9	1.7	-1.3	-0.0	1.1	0.9	0.9	-0.8
Angina	0.4	0.5	1.3	-0.5	-0.5	1.1	0.8	0.8	-0.3
Current tobacco smoking	0.4	0.7	1.9	-0.5	-0.7	-1.4	-0.8	-0.7	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.1	-1.0	-0.9	-0.6	-0.5	-0.1
High blood pressure	0.4	1.2	3.8	-1.0	-1.4	0.7	0.1	0.1	-2.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.5	0.1	0.5	1.2	0.8	0.9	-0.5
Had other major operations	0.4	0.5	2.1	1.4	0.3	0.7	-0.1	-0.0	0.4
Worrier / anxious feelings	0.4	0.7	1.4	-1.2	0.6	1.0	0.9	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.1	0.9	1.4	0.0	0.2	0.2	2.2
Asthma	0.4	0.9	1.9	0.3	0.5	1.4	1.1	1.1	0.9
Medication: Lansoprazole	0.4	0.4	1.4	-0.1	-0.1	1.2	0.8	0.7	-0.1
Prospective memory result	0.4	0.4	2.3	-0.1	-0.3	0.4	-0.0	-0.0	-1.5
Illnesses of mother	0.4	0.5	1.0	0.8	-0.7	-0.6	-0.4	-0.3	1.0
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.6	-1.0	-0.6	-0.6	-0.6	-0.6
High blood pressure (siblings)	0.4	0.6	2.7	-0.1	0.1	0.7	0.3	0.3	-1.7
Worry too long after embarrassment	0.4	0.6	1.3	-0.2	-1.0	-1.1	-0.8	-0.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.6	0.8	-0.9	-0.5	0.2	0.2	1.3
Pulse wave peak to peak time	0.4	0.4	0.8	0.6	0.9	0.7	0.6	0.6	0.5
Shortness of breath walking on level ground	0.4	0.5	0.7	-0.6	-0.8	0.0	-0.8	-0.9	-0.8
Neck or shoulder pain in last month	0.4	0.6	0.9	0.4	0.8	1.0	0.9	0.9	-0.1
Angina (self-reported)	0.4	0.5	1.3	-0.5	-0.3	1.1	0.8	0.9	0.0
Alcohol intake frequency.	0.4	1.0	3.2	-1.3	-1.8	-0.5	-0.4	-0.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.0	-0.7	-1.4	0.0	-0.4	-0.4	-0.5
Hypertension (Self-reported)	0.4	1.2	3.4	-1.0	-1.6	0.4	0.1	0.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.9	-0.1	0.4	1.0	1.0	0.5
Smoking status: Previous	0.4	0.5	2.8	1.7	-0.2	0.2	0.1	0.0	0.7
Qualifications: nursing, teaching	0.4	0.7	2.1	-1.4	0.0	0.3	-0.1	-0.2	-1.4
Medication: Aspirin	0.4	0.5	0.9	-0.9	-0.5	0.9	0.4	0.3	-0.9
Medication: Gliclazide	0.4	0.5	1.2	-1.1	-0.7	0.1	-0.1	-0.1	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	1.0	0.4	0.3	0.8	1.0	0.1
Number of operations (self-reported)	0.4	0.5	2.5	0.6	0.3	0.5	0.1	0.2	-1.6
Irritability	0.4	0.6	1.0	-0.0	0.7	0.9	0.9	1.0	0.6
Risk taking	0.4	0.6	1.2	0.7	-0.6	-0.5	-1.1	-1.1	-0.5
Diastolic blood pressure, automated reading	0.4	1.3	2.8	1.7	0.7	0.5	1.2	1.2	1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.9	0.1	0.1	0.6	0.6	1.0
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.4	1.0	0.3	-0.1	-0.1	0.7
Reaction Time	0.3	0.6	2.5	-0.9	0.1	0.4	-0.2	-0.2	-1.6
Age at First Birth	0.3	0.5	0.9	-0.7	-0.7	-0.7	-1.0	-0.5	-0.5
HDL Cholesterol	0.3	0.6	1.9	1.1	-0.2	-0.4	-0.0	-0.1	1.4
Waist Hip Ratio (WHR)	0.3	1.1	4.5	0.3	-0.5	-2.1	-0.9	-0.8	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	0.5	-0.0	-0.4	-0.2	-0.3	1.3
Medication: Co-codamol	0.3	0.4	1.8	0.4	0.5	-0.1	0.3	0.3	1.3
Maternal smoking around birth	0.3	0.4	1.0	-0.3	0.3	1.0	0.7	0.6	0.6
Sitting height	0.3	2.1	7.6	2.8	-1.6	0.0	-1.0	-1.1	0.4
Number of incorrect matches in round	0.3	0.6	1.2	1.1	0.7	0.9	0.4	0.3	-0.8
Alcohol usually taken with meals	0.3	0.5	1.4	0.9	-0.2	-1.2	-0.6	-0.5	0.2
Nervous feelings	0.3	0.6	1.2	-1.1	-0.9	-0.1	-0.8	-0.9	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	-0.3	0.9	1.1	0.3	0.2	-0.0
Falls in the last year	0.3	0.5	2.4	-1.5	0.1	0.2	0.1	-0.1	-0.5
Happiness	0.3	0.3	1.0	-0.5	-1.0	-0.5	-0.5	-0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.3	-0.1	1.5	0.6	0.6	0.7	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.5	0.4	1.9	0.2	0.3	0.3	1.2
Peak expiratory flow (PEF)	0.3	0.8	1.3	-0.4	-0.0	-1.0	-1.1	-1.1	1.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	-0.5	0.8	1.2	0.6	0.6	-0.1
Suffer from ‘nerves’	0.3	0.5	2.0	-1.4	-0.7	0.5	-0.2	-0.3	-0.1
Family relationship satisfaction	0.3	0.3	0.6	-0.1	0.1	0.7	0.7	0.7	0.8
Mood swings	0.3	0.5	1.9	1.1	0.1	-0.1	-0.2	-0.2	1.4
Miserableness	0.3	0.4	1.3	1.1	0.2	0.0	-0.6	-0.5	0.9
Financial situation satisfaction	0.3	0.4	1.2	-1.1	-0.2	0.6	-0.4	-0.4	0.7
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.4	-0.2	-0.7	-0.8	-0.8	0.3
Medication: Blood pressure	0.3	0.6	2.0	0.3	-0.8	1.4	0.5	0.5	0.0
Fractured/broken bones in last 5 years	0.3	0.3	1.1	-0.4	-0.5	-0.4	-0.3	-0.4	-1.1
Myopia	0.3	0.4	0.5	-0.7	-0.3	0.6	0.7	0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.1	0.8	1.2	-1.1	-0.4	-0.4	1.5
Pack years of smoking	0.3	0.4	0.9	-0.6	0.5	0.9	0.7	0.8	0.1
Depression (Nagel 2018)	0.2	0.2	0.9	-0.3	-0.4	-0.5	0.0	-0.1	0.9
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.9	0.1	-0.4	-0.5	-0.6	0.9
Crohns Disease (2017)	0.2	0.3	0.7	-0.2	-0.6	-0.7	-0.5	-0.4	0.8
Irritable Bowel Disease (IBD)	0.2	0.4	1.5	-1.2	-0.6	-0.6	0.0	0.2	0.5
Ulcerative Colitis (UC)	0.2	0.4	1.5	-1.2	-0.3	0.1	0.6	0.8	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	0.5	-0.3	-0.3	0.3	0.4	0.9
Neuroticism (2016)	0.2	0.4	0.7	-0.2	-0.5	-0.4	-0.7	-0.8	0.7
Schizophrenia (2014)	0.2	0.5	1.1	0.3	0.6	0.5	1.0	1.0	0.4
Blood White Count	0.2	1.4	3.6	-0.2	-1.2	-1.9	-1.2	-1.3	-0.2
Smoking Status	0.2	0.6	1.4	0.7	-0.1	-0.8	-0.7	-0.8	1.2
Allergy or Eczema	0.2	0.6	1.3	0.6	1.1	0.9	0.7	0.8	0.1
Cardiovascular Disease	0.2	0.7	2.1	-0.2	-1.5	-0.4	-0.8	-0.8	-0.8
Neuroticism	0.2	0.4	0.7	-0.6	-0.2	-0.6	-0.8	-0.7	0.8
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.5	-0.5	-0.8	-0.8	-0.8	-0.2
Diabetes (mother)	0.2	0.2	0.5	0.5	0.4	-0.1	0.7	0.6	-0.3
Pack years adult smoking proportion	0.2	0.2	0.4	-0.6	0.2	0.5	0.4	0.4	0.7
Average weekly fortified wine intake	0.2	0.2	0.7	-0.1	0.0	-0.5	-0.3	-0.3	0.9
Taking other prescription medications	0.2	0.3	1.1	-0.3	-0.7	0.3	-0.0	0.1	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.4	0.2	1.2	0.8	0.5	0.5	-0.1
Medication: Atenolol	0.2	0.3	0.6	0.8	-0.7	0.1	-0.5	-0.5	-0.4
Impedance of leg (left)	0.2	0.9	3.1	-0.2	1.7	0.0	0.9	0.9	0.9
Waist circumference	0.2	0.9	2.2	-0.3	-0.6	-1.5	-1.0	-1.0	-0.5
Past tobacco smoking	0.2	0.4	1.8	-1.4	0.3	0.4	0.2	0.2	-0.7
Had menopause	0.2	0.2	0.6	0.5	-0.3	-0.8	-0.3	-0.3	-0.5
Qualifications: None of the above	0.2	0.4	1.5	-0.1	-0.7	-1.2	-0.6	-0.6	0.1
Mouth/teeth dental problems	0.2	0.2	0.6	0.2	-0.1	-0.7	-0.6	-0.6	0.1
Neuroticism score	0.2	0.4	1.4	-0.1	-0.3	-0.5	-0.7	-0.7	1.2
Impedance of arm (right)	0.2	0.9	2.4	-1.0	-0.4	-1.6	-0.9	-0.8	0.7
Arm fat percentage (right)	0.2	0.7	1.6	-1.3	0.3	-1.2	-0.7	-0.6	-0.3
Noisy workplace	0.2	0.3	1.1	-0.5	0.1	0.4	-0.1	0.0	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	-1.0	0.4	0.3	0.3	0.3	-0.2
Lung cancer (father)	0.2	0.2	0.5	-0.6	-0.4	0.4	0.2	0.2	-0.7
Arm fat mass (right)	0.2	0.6	1.1	-1.0	-0.0	-1.1	-0.8	-0.9	-0.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	0.3	-0.5	-1.0	-0.3	-0.3	0.9
Birth weight of first child	0.2	0.3	1.2	1.1	-0.2	0.5	-0.1	-0.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.4	0.6	0.7	0.5	0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.8	-0.2	-0.2	-0.4	-0.3	0.8
Birth weight	0.2	0.4	0.9	0.6	-0.3	-0.4	-0.8	-0.9	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.5	0.3	-0.2	-0.4	-0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	1.0	0.4	-0.3	-0.1	-0.0	-0.5
Age at first live birth	0.2	0.4	0.8	-0.9	-0.7	-0.2	-0.7	-0.8	-0.3
Medication: Omeprazole	0.2	0.2	0.6	-0.2	-0.6	0.4	-0.1	-0.2	-0.8
Mean time to correctly identify matches	0.2	0.3	1.6	-0.1	-0.3	0.2	-0.2	-0.3	-1.3
Illnesses of father: Heart disease	0.2	0.3	1.3	0.1	0.7	-1.1	0.1	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.6	0.6	0.5	0.8	0.8	0.7	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.0	0.3	0.2	-0.7	-0.6	-0.4
Back pain experienced in last month	0.2	0.3	1.1	0.4	0.5	1.0	0.5	0.5	0.1
Medication: Lisinopril	0.2	0.3	0.5	0.3	-0.0	0.6	0.7	0.7	-0.6
Alcohol drinker status: Never	0.2	0.3	0.7	0.2	-0.8	-0.5	-0.6	-0.6	-0.1
Ever smoked	0.2	0.3	0.8	0.9	0.2	-0.6	-0.1	-0.0	0.9
Age started oral contraceptive pill	0.2	0.3	0.6	0.2	0.8	-0.5	0.6	0.5	-0.5
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.3	0.6	0.4	-0.1	-0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.1	0.2	0.8	0.6	0.4	-0.7
Pain experienced in last month	0.2	0.3	0.9	0.1	-0.4	-0.7	-0.2	-0.3	-1.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	-0.6	-0.1	0.5	0.2	0.2	-0.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	-0.3	0.5	0.1	-0.2	-0.3	0.5
Schizophrenia (2018)	0.1	0.2	0.4	0.0	0.6	0.4	0.5	0.5	0.6
Worry (Nagel 2018)	0.1	0.3	1.3	-1.1	-0.1	0.3	-0.1	-0.1	0.6
Breast Cancer	0.1	0.2	0.5	-0.4	-0.2	-0.7	-0.3	-0.4	-0.7
Blood Eosinophil Count	0.1	0.5	1.4	-0.3	-1.2	0.3	0.2	0.2	-1.1
Blood Red Count	0.1	1.4	8.1	2.8	-0.1	0.0	0.1	0.0	-0.6
BMI	0.1	0.4	1.0	-0.1	-0.1	-0.5	-1.0	-1.0	-0.2
Height	0.1	1.3	4.0	0.2	0.8	1.6	0.5	0.3	-2.0
Hypothyroidism (self reported)	0.1	0.3	1.0	-0.7	0.4	0.2	0.1	0.0	-1.0
Tanning	0.1	1.0	3.7	0.0	0.8	0.8	0.8	0.8	-1.9
Hand grip strength (left)	0.1	0.3	0.8	0.1	0.9	0.4	0.5	0.6	0.6
Number of treatments/medications taken	0.1	0.2	0.4	0.5	-0.2	0.3	0.6	0.5	-0.4
Severe depression (siblings)	0.1	0.1	0.3	-0.3	-0.2	0.6	0.1	0.2	0.4
Impedance of leg (right)	0.1	0.7	3.1	0.1	1.8	-0.2	0.4	0.4	0.9
Leg fat-free mass (left)	0.1	0.5	0.7	-0.4	-0.7	0.2	-0.8	-0.9	-0.8
Trunk fat percentage	0.1	0.4	0.9	-0.8	0.3	-1.0	-0.6	-0.6	-0.5
Hand grip strength (right)	0.1	0.2	0.2	0.4	-0.5	-0.4	-0.5	-0.5	0.2
Fed-up feelings	0.1	0.2	0.7	-0.4	0.8	0.5	0.2	0.2	-0.4
Supplements: Glucosamine	0.1	0.1	0.6	0.1	0.8	-0.1	0.1	0.1	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.6	0.1	-0.4	-0.3	-0.6	-0.6	0.8
Leg predicted mass (left)	0.1	0.6	1.0	-0.4	-0.9	0.0	-0.9	-1.0	-0.8
Trunk fat mass	0.1	0.4	0.6	-0.6	0.1	-0.7	-0.7	-0.8	-0.6
Weight	0.1	0.3	0.6	-0.4	-0.2	-0.3	-0.7	-0.8	-0.4
Hip circumference	0.1	0.3	0.4	-0.5	-0.4	-0.5	-0.5	-0.6	-0.7
Impedance of arm (left)	0.1	0.4	1.3	-0.5	-0.1	-1.1	-0.6	-0.5	0.4
Tense / ‘highly strung’	0.1	0.2	0.3	-0.5	0.3	-0.4	-0.5	-0.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.2	0.2	-0.4	-0.6	-0.6	-0.6
Headache pain in last month	0.1	0.2	0.6	0.1	-0.6	-0.8	-0.2	-0.2	0.1
Body fat percentage	0.1	0.4	0.7	-0.8	0.6	-0.8	-0.4	-0.4	-0.3
Leg fat percentage (right)	0.1	0.4	2.1	-0.5	1.5	-0.2	0.2	0.1	-0.0
Arm fat-free mass (right)	0.1	0.5	1.8	0.1	-0.3	0.6	-0.3	-0.5	-1.4
Qualifications: College or University degree	0.1	0.3	0.9	0.9	0.5	0.4	-0.3	-0.5	0.1
Heart disease (mother)	0.1	0.1	0.5	0.7	0.5	0.0	-0.1	-0.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.0	0.1	-0.1	0.6	0.5	0.1
Whole body fat mass	0.1	0.4	0.6	-0.6	0.1	-0.7	-0.7	-0.8	-0.5
Leg fat mass (right)	0.1	0.2	0.5	-0.6	0.7	-0.4	-0.3	-0.4	-0.3
Arm predicted mass (right)	0.1	0.3	0.8	0.4	-0.4	0.5	-0.3	-0.4	-0.9
Comparative height size at age 10	0.1	0.7	2.2	-1.3	-0.4	-0.0	-0.5	-0.5	-1.5
Overall health rating	0.1	0.2	0.4	-0.5	-0.2	0.7	0.2	0.2	-0.5
Supplements: Vitamin C	0.1	0.1	0.3	-0.5	0.3	-0.0	-0.2	-0.4	-0.1
Whole body fat-free mass	0.1	0.3	0.4	-0.0	-0.7	0.6	-0.5	-0.6	-0.7
Leg fat-free mass (right)	0.1	0.3	0.7	-0.4	-0.8	0.3	-0.4	-0.5	-0.8
Arm fat percentage (left)	0.1	0.5	1.1	-0.9	0.4	-1.1	-0.5	-0.5	-0.4
Friendships satisfaction	0.1	0.1	0.6	-0.1	0.2	0.8	0.0	-0.1	-0.2
Leg predicted mass (right)	0.1	0.4	0.9	-0.5	-0.8	0.3	-0.4	-0.4	-0.9
Arm fat mass (left)	0.1	0.5	1.1	-0.6	-0.1	-1.1	-0.8	-0.9	-0.5
Guilty feelings	0.1	0.2	0.7	-0.3	0.6	0.1	0.1	0.0	0.8
Wears glasses or contact lenses	0.1	0.1	0.6	-0.2	0.1	-0.8	-0.1	-0.1	-0.3
Medication: Atorvastatin	0.1	0.2	0.6	-0.5	-0.3	-0.0	-0.3	-0.4	0.7
Leg fat percentage (left)	0.1	0.5	2.0	-0.8	1.4	-0.0	0.4	0.4	-0.1
Arm fat-free mass (left)	0.1	0.3	0.5	-0.3	-0.7	0.2	-0.6	-0.7	-0.5
Ever depressed for a whole week	0.1	0.2	0.3	0.5	-0.4	-0.2	-0.3	-0.3	0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	0.1	-0.6	-0.3	-0.3	-0.3	-0.2
Impedance of whole body	0.1	0.4	1.1	-0.5	0.4	-1.1	-0.4	-0.3	0.8
Arm predicted mass (left)	0.1	0.4	0.8	0.1	-0.9	0.0	-0.7	-0.9	-0.5
Blood Platelet Count	0.0	0.4	1.3	-0.2	-0.9	-0.7	-0.0	0.0	-1.1
Hair Pigment	0.0	1.3	3.2	0.9	0.6	0.7	1.7	1.8	0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	-0.1	0.2
Body mass index (BMI)	0.0	0.2	0.3	-0.6	0.1	-0.5	-0.4	-0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	-0.2	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2	0.2	-0.0
Trunk fat-free mass	0.0	0.3	0.6	0.4	-0.6	0.8	-0.4	-0.6	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.1	-0.3	0.2	0.2	0.2	-0.2
Trunk predicted mass	0.0	0.3	0.6	0.4	-0.6	0.8	-0.3	-0.5	-0.4
Standing height	0.0	0.4	1.0	0.5	-0.9	0.1	-0.8	-1.0	0.0
Loud music exposure frequency	0.0	0.0	0.0	-0.0	0.2	0.2	0.2	0.2	-0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.4	0.0	0.1	0.1	0.1	-0.2
Medication: Allopurinol	0.0	0.0	0.1	0.0	-0.2	0.1	0.2	0.3	0.0
Whole body water mass	0.0	0.3	0.4	0.0	-0.6	0.6	-0.4	-0.6	-0.7
Basal metabolic rate	0.0	0.2	0.4	-0.1	-0.6	0.3	-0.5	-0.7	-0.6
Heart disease (siblings)	0.0	0.0	0.1	0.0	-0.2	-0.2	-0.1	-0.1	-0.3
Leg fat mass (left)	0.0	0.2	0.5	-0.7	0.7	-0.2	-0.1	-0.2	-0.3

Hub : Genes

DSP

Models

Trait associations