Best TWAS P=1.38e-10 · Best GWAS P=1.01e-41 conditioned to 4.52e-44
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HMGCLL1 | 0.38 | 0.17 | lasso | 25 | 0.34 | 1.2e-42 | 2.0 | 5.8 | 5.7e-09 | 0.01 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | COL21A1 | 0.35 | 0.40 | lasso | 2 | 0.32 | 7.6e-09 | -6.4 | -6.4 | 1.4e-10 | 0.00 | 0.97 | 0.00 | TRUE |
| 3 | GTEx | Brain Cerebellum | COL21A1 | 0.45 | 0.35 | lasso | 2 | 0.31 | 8.7e-10 | -6.4 | -6.4 | 1.4e-10 | 0.00 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | COL21A1 | 0.11 | 0.07 | lasso | 14 | 0.05 | 7.7e-05 | -5.1 | 5.4 | 7.9e-08 | 0.16 | 0.86 | 0.01 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | HMGCLL1 | 0.15 | 0.08 | bslmm | 487 | 0.14 | 1.2e-17 | -9.7 | 5.3 | 8.9e-08 | -0.08 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HMGCLL1 | 0.02 | 0.01 | lasso | 4 | 0.01 | 2.3e-03 | 6.7 | -6.4 | 2.0e-10 | 0.07 | 0.20 | 0.18 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | COL21A1 | 0.09 | 0.01 | blup | 245 | 0.02 | 1.5e-02 | -2.8 | 5.7 | 1.5e-08 | 0.09 | 0.12 | 0.04 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PRIM2 | 0.11 | 0.07 | enet | 13 | 0.08 | 1.2e-08 | -4.3 | -5.9 | 3.6e-09 | 0.05 | 0.03 | 0.87 | TRUE |