Hub : Genes

HMGCLL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.378	0.0480	0.0e+00	0.173	0.290	0.316	0.315	0.339	1.4e-20	1.4e-35	3.4e-39	4.7e-39	1.2e-42
2	ROSMAP	Brain Pre-frontal Cortex	0.154	0.0372	9.7e-13	0.078	0.122	0.128	0.141	0.132	2.9e-10	2.2e-15	3.6e-16	1.2e-17	1.4e-16
3	TCGA	Breast Invasive Carcinoma	0.021	0.0119	2.1e-03	0.007	0.009	0.009	NA	0.011	1.3e-02	4.6e-03	4.1e-03	NA	2.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.5	0.4	1.2	-0.6
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.0	0.3	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.2	0.5	0.4
Depression (Nagel 2018)	0.1	0.2	0.6	-0.8	-0.0	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	1.0	0.1	-0.2
Neuroticism (Nagel 2018)	0.5	1.3	1.4	1.0	1.2	-1.2
Schizophrenia (2018)	0.1	0.3	0.4	-0.3	-0.6	0.7
Schizophrenia vs Biploar Disorder	1.1	1.5	2.3	-1.3	-0.6	1.5
Worry (Nagel 2018)	1.5	3.1	4.7	1.5	1.6	-2.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	0.4	0.2	-0.9
Alzheimer’s Disease (in father)	1.8	1.9	2.7	1.6	0.9	-1.5
Alzheimer’s Disease (including proxy)	0.9	1.3	2.0	1.2	0.6	-1.4
Crohns Disease (2017)	0.9	2.0	4.7	1.0	0.3	-2.2
Irritable Bowel Disease (IBD)	0.8	1.8	4.1	1.1	0.4	-2.0
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.5	0.2	-0.9
Major Depression (MDD)	0.1	0.2	0.3	-0.5	-0.3	-0.3
Reaction Time	0.2	0.4	0.7	0.6	0.8	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.1	-0.5	0.8
Breast Cancer	0.3	0.8	1.6	0.4	0.7	1.3
Ovarian Cancer	0.6	0.8	2.0	-0.1	0.7	1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.7	3.8	0.7	0.8	-1.9
Bipolar Disorder (2011)	0.7	0.6	1.3	0.6	1.1	-0.6
Body Mass Index (BMI) (2010)	0.4	0.6	0.9	-0.3	-0.9	0.9
Coronary Artery Disease (CAD)	0.8	0.9	1.9	0.1	0.9	-1.4
Crohns Disease (2012)	0.7	1.1	2.0	-0.7	-0.9	-1.4
Mean Putamen Volume	2.5	2.8	5.7	-0.8	-2.4	1.5
Fasting Glucose	0.3	0.4	0.7	0.8	0.4	-0.6
HbA1C	0.9	1.0	2.3	1.5	0.8	-0.4
HDL Cholesterol	1.4	2.3	5.5	1.2	0.0	-2.3
LDL Cholesterol	0.1	0.2	0.3	0.5	0.4	-0.4
Lupus	2.3	3.5	4.9	2.2	1.7	-1.6
Neuroticism (2016)	1.1	1.6	2.8	0.8	1.2	-1.7
Primary Biliary Cirrhosis	0.4	0.5	1.6	0.1	0.1	-1.3
Rheumatoid Arthritis	2.5	3.4	6.1	1.4	2.5	-1.5
Schizophrenia (2014)	0.0	0.0	0.0	0.1	-0.1	0.2
Triglycerides	0.5	0.9	1.7	-0.6	0.7	1.3
Type 2 Diabetes (T2D) (2012)	3.9	4.5	5.7	2.4	2.0	-2.0
Ulcerative Colitis	0.0	0.0	0.1	-0.0	0.1	-0.3
Blood Eosinophil Count	0.1	0.5	1.0	-1.0	-0.7	-0.2
Blood Platelet Count	0.0	0.1	0.4	-0.7	-0.1	0.1
Blood Red Count	0.1	0.8	2.1	0.7	1.4	-0.1
Blood White Count	0.0	0.0	0.0	0.2	0.1	-0.1
Heel T-Score	4.3	34.3	40.4	5.8	5.3	-6.4
BMI	0.1	0.8	1.1	-1.0	-0.9	0.6
Height	0.0	0.8	1.7	1.3	0.4	-0.8
Waist Hip Ratio (WHR)	0.1	0.6	1.7	0.0	0.4	1.3
Systolic Blood Pressure	0.1	0.6	1.3	-1.1	-0.7	0.1
Smoking Status	0.2	0.5	0.7	-0.8	-0.8	0.5
Allergy or Eczema	0.1	0.2	0.6	-0.0	0.0	-0.8
Cardiovascular Disease	0.5	1.8	3.8	-1.2	-1.9	-0.4
Hypothyroidism (self reported)	0.7	1.6	2.3	1.4	1.5	-0.7
Respiratory disease	0.1	0.2	0.5	-0.2	0.3	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	-1.1	-0.6	0.0
Lung FEV1/FVC ratio	0.6	3.1	4.9	2.2	1.3	-1.6
Lung FVC	0.9	4.6	7.6	-2.8	-2.2	1.1
Neuroticism	1.2	3.0	3.9	1.3	1.8	-2.0
Chronotype (morning person)	6.1	14.2	20.9	-4.6	-1.9	4.2
Hair Pigment	0.0	0.1	0.3	-0.6	0.0	-0.1
Tanning	0.0	0.2	0.6	0.1	0.7	-0.2
Hand grip strength (left)	0.0	0.1	0.1	0.3	-0.3	0.2
Number of treatments/medications taken	0.5	1.0	1.3	-1.2	-1.1	0.5
Average weekly spirits intake	0.2	0.3	0.6	0.7	-0.1	0.5
Sensitivity / hurt feelings	1.2	2.0	3.9	0.8	2.0	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	-1.4	-0.6	0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.3	-0.4	0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.3	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.6	0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.2	0.3	1.5	-0.6
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.0	-0.2	-0.2
Systolic blood pressure, automated reading	0.5	1.4	2.5	-1.6	-1.3	0.3
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	4.8	-1.0	-1.5	2.2
Angina	0.3	0.4	0.6	0.8	0.5	-0.6
Medication for hormone replacement therapy	0.3	0.4	0.7	0.1	0.6	0.9
Vitamin and mineral supplements	0.2	0.3	0.5	0.6	0.7	-0.3
Supplements: Zinc	3.3	3.6	6.1	2.5	1.4	-1.7
Medication: Co-codamol	0.1	0.1	0.2	-0.0	-0.4	0.4
Medication: Metformin	0.4	0.6	0.8	-0.9	-0.8	0.5
Diabetes (father)	0.6	0.7	1.2	0.9	0.4	-1.1
Diabetes (mother)	0.2	0.2	0.5	0.3	-0.4	0.7
Severe depression (siblings)	0.8	0.9	1.4	-1.2	-0.2	1.1
Pack years adult smoking proportion	1.7	2.5	2.9	-1.7	-1.4	1.7
Impedance of leg (right)	0.1	0.6	0.9	0.8	0.3	-1.0
Leg fat-free mass (left)	0.2	0.8	1.5	-0.7	-0.7	1.2
Trunk fat percentage	0.4	1.8	3.2	-1.4	-1.8	0.5
Hand grip strength (right)	0.3	0.8	2.1	1.5	0.4	-0.4
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.2	0.7	-0.1
Current tobacco smoking	0.5	0.8	0.9	0.9	0.9	-0.8
Average weekly fortified wine intake	0.6	0.7	1.4	-1.2	-0.4	0.7
Maternal smoking around birth	0.4	0.6	1.0	-0.7	-0.4	1.0
Fed-up feelings	0.3	0.5	1.2	0.4	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	0.6	0.4	-1.0
Relative age voice broke	0.1	0.2	0.4	-0.6	-0.5	0.3
Taking other prescription medications	0.1	0.2	0.4	-0.6	-0.4	0.3
Age when periods started (menarche)	0.1	0.3	0.8	0.4	-0.9	-0.0
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	3.3	1.5	1.4	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.5	0.7	1.0	-1.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.0	0.2	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.4	0.4	-0.9
Serious illness, injury or assault to yourself	3.0	3.6	5.0	-2.2	-1.9	1.5
High blood pressure	0.3	0.9	1.1	-0.8	-1.1	-1.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.5	0.8	0.7	-1.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.3	-0.5	0.2
Stomach or abdominal pain in last month	0.6	0.7	1.3	0.5	0.8	-1.1
Supplements: Glucosamine	0.3	0.4	0.6	0.5	0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	3.8	1.7	1.1	-1.9
Medication: Atenolol	0.5	0.7	0.8	0.9	-0.7	-0.8
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.1	0.6	-0.3
Sitting height	0.6	4.0	9.4	-1.4	-0.8	3.1
Chronic bronchitis/emphysema (father)	2.7	3.1	3.4	1.6	1.8	-1.8
High blood pressure (mother)	0.2	0.2	0.6	-0.2	0.2	-0.8
Body mass index (BMI)	0.2	0.8	1.1	-1.1	-1.1	0.3
Impedance of leg (left)	0.2	0.9	1.5	1.0	0.5	-1.2
Leg predicted mass (left)	0.1	0.8	1.4	-0.7	-0.7	1.2
Trunk fat mass	0.3	1.3	2.2	-1.1	-1.5	0.7
Waist circumference	0.4	1.6	2.2	-1.5	-1.2	1.1
Number of incorrect matches in round	0.8	1.3	2.8	1.7	0.9	-0.6
Past tobacco smoking	0.7	1.2	2.0	1.3	1.4	-0.3
Alcohol usually taken with meals	0.7	1.1	1.7	-1.2	-1.3	0.4
Nervous feelings	1.1	2.1	3.3	1.8	1.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.7	0.1	-0.9
Hearing difficulty/problems with background noise	0.2	0.4	1.1	-0.0	-0.3	1.0
Hair/balding pattern: Pattern 2	1.3	1.6	3.2	-1.1	-1.8	0.6
Had menopause	0.0	0.0	0.0	-0.2	-0.1	0.1
Had other major operations	0.8	0.9	1.9	0.9	1.4	-0.4
Forced vital capacity (FVC)	0.4	1.5	2.1	-1.1	-1.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	5.8	2.0	2.3	-2.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	-0.7	-1.1	-0.6
Qualifications: None of the above	0.3	0.6	1.1	0.5	1.0	-0.6
Financial difficulties in last 2 years	0.4	0.6	0.7	0.7	0.7	-0.8
Mouth/teeth dental problems	0.2	0.3	0.7	0.9	0.3	0.4
Heart attack	0.1	0.1	0.2	-0.1	-0.5	-0.2
Allergy	0.0	0.1	0.2	0.1	-0.1	0.5
Pain all over the body in last month	0.4	0.4	0.5	-0.5	-0.7	0.7
Diabetes (self-reported)	0.5	0.8	1.5	-1.2	-0.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	0.3	0.5	-0.4
Medication: Ramipril	0.6	0.7	1.3	-1.1	-0.8	-0.5
Medication: Simvastatin	0.6	0.9	1.7	-1.0	-1.3	-0.1
Fluid intelligence score	0.1	0.2	0.6	0.8	-0.1	0.2
Illnesses of siblings	0.3	0.4	0.9	-0.2	-0.9	0.6
Neuroticism score	1.0	2.2	3.7	1.2	1.2	-1.9
Weight	0.2	1.0	1.3	-0.9	-1.1	0.9
Impedance of arm (right)	0.5	2.2	3.6	-1.3	-1.9	1.1
Arm fat percentage (right)	0.7	2.6	4.0	-1.7	-2.0	1.0
Trunk fat-free mass	0.0	0.3	0.6	0.2	0.3	0.8
Hip circumference	0.8	3.5	6.2	-1.7	-2.5	1.2
Time employed in main current job	0.9	1.1	1.5	1.2	0.8	-1.0
Alcohol intake versus 10 years previously	0.6	0.9	1.1	1.0	1.0	-0.8
Father’s age at death	0.2	0.2	0.5	-0.3	-0.4	0.7
Worrier / anxious feelings	1.9	3.6	6.2	1.9	1.1	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.8	-0.8	-0.9	0.5
Falls in the last year	1.3	1.7	2.5	0.9	1.3	-1.6
Hair/balding pattern: Pattern 3	0.3	0.5	0.6	0.7	0.8	-0.6
Number of live births	0.2	0.2	0.7	-0.2	0.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	-0.3	-0.7	0.4
Pulse rate	0.2	0.3	0.7	-0.0	0.9	0.2
Happiness	1.4	1.7	3.7	1.0	0.8	-1.9
Noisy workplace	2.8	3.4	5.6	-2.0	-0.8	2.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.0	-0.7	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	-0.6	-1.0	0.3
Mouth/teeth dental problems: Dentures	1.9	3.2	6.6	-2.6	-1.4	1.1
Asthma	0.1	0.2	0.3	-0.3	0.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.2	0.0	0.4
Medication: Cholesterol lowering	1.5	2.4	2.8	-1.4	-1.7	1.5
Depression (self-reported)	0.3	0.4	0.5	0.6	0.7	-0.7
Medication: Lansoprazole	1.0	1.2	2.3	-0.8	-1.5	0.7
Prospective memory result	1.4	1.7	2.8	1.1	1.1	-1.7
Lung cancer (father)	0.6	0.7	1.0	1.0	0.8	-0.7
Illnesses of mother	0.3	0.3	0.8	0.9	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.4	-0.0	-0.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	-1.2	-0.3	0.2
Impedance of arm (left)	0.5	2.3	3.6	-1.4	-1.9	1.2
Arm fat mass (right)	0.2	0.6	1.3	-0.7	-1.1	0.4
Trunk predicted mass	0.0	0.3	0.7	0.2	0.2	0.8
Standing height	0.1	0.8	2.2	0.2	-0.3	1.5
Length of working week for main job	0.3	0.4	1.0	0.2	0.3	1.0
Exposure to tobacco smoke at home	0.3	0.4	1.0	0.3	-0.2	-1.0
Breastfed as a baby	1.5	1.9	3.2	-1.5	-0.4	1.8
Tense / ‘highly strung’	1.9	3.1	3.7	1.4	1.9	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.3	0.5	0.1	-1.8
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.2	-0.0	-0.4
Birth weight of first child	0.0	0.1	0.1	0.4	0.1	0.3
Peak expiratory flow (PEF)	0.2	0.6	0.9	0.9	0.7	-0.6
Pulse wave reflection index	0.3	0.3	0.8	-0.9	-0.4	0.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.8	0.6	1.3	-1.7
Loud music exposure frequency	0.1	0.1	0.1	-0.3	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	2.3	-0.6	-1.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	0.4	0.3	-1.0
Blood clot in the leg (DVT)	2.2	2.8	3.3	-1.4	-1.8	1.8
Medication: Paracetamol	0.5	0.9	1.6	-0.5	-0.9	1.3
Headache pain in last month	1.0	1.7	4.2	-0.7	-2.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.1	1.0	1.0	-0.5
Glaucoma (self-reported)	0.1	0.2	0.4	0.0	0.2	-0.7
Gout (self-reported)	0.2	0.2	0.4	-0.2	0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	0.1	0.8	0.0
Medication: Amlodipine	1.2	1.6	2.3	-1.5	-1.3	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.3	-1.1	-1.0	1.1
Birth weight	0.4	0.9	2.3	-0.5	-0.4	1.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.5	-1.1	-1.6	1.0
High blood pressure (siblings)	0.4	0.5	0.9	0.6	0.5	-1.0
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.2	-0.2	-0.2
Body fat percentage	0.4	1.5	2.9	-1.2	-1.7	0.4
Leg fat percentage (right)	0.2	0.6	1.2	-0.7	-1.1	-0.1
Arm fat-free mass (right)	0.1	0.4	0.7	0.8	0.8	0.0
Exposure to tobacco smoke outside home	4.1	5.4	9.8	1.7	1.9	-3.1
Comparative body size at age 10	2.8	7.8	10.2	-2.7	-3.2	2.5
Number of full brothers	1.6	2.1	3.1	1.2	1.8	-1.2
Worry too long after embarrassment	2.9	4.9	8.4	2.3	1.1	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.5	0.3	-0.1
Wheeze or whistling in the chest in last year	1.0	1.7	3.6	-1.1	-1.9	0.6
Number of children fathered	0.3	0.3	0.5	0.3	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.9	1.2	1.7	-0.8
Age at first live birth	0.3	0.5	1.0	0.3	-1.0	-0.5
Pulse wave peak to peak time	0.4	0.5	1.4	1.2	0.4	-0.2
Health satisfaction	0.4	0.5	0.9	-1.0	-0.6	-0.4
Shortness of breath walking on level ground	1.9	2.2	3.7	1.4	1.0	-1.9
Qualifications: College or University degree	0.1	0.2	0.3	0.3	0.5	0.5
Eye problems/disorders: None of the above	0.8	1.0	1.5	0.6	1.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.6	-1.1	-1.2	0.5
Emphysema/chronic bronchitis	0.9	1.1	1.5	-1.0	-0.8	1.2
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	0.8	1.0	-1.6
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.0	0.6	-0.3
Medication: Blood pressure	0.4	0.8	1.8	-0.7	-1.3	0.2
Angina (self-reported)	0.2	0.3	0.4	0.6	0.5	-0.6
Migraine (self-reported)	2.3	2.9	6.1	-1.4	-2.5	0.7
Medication: Ibuprofen	0.0	0.0	0.1	0.2	0.1	0.3
Medication: Allopurinol	0.1	0.1	0.2	-0.4	0.3	0.3
Medication: Omeprazole	0.1	0.1	0.2	-0.4	-0.4	-0.2
Medication: Seretide 50 evohaler	1.1	1.3	2.1	-1.5	-0.8	1.1
Mean time to correctly identify matches	0.5	0.9	0.9	1.0	0.9	-0.9
Heart disease (mother)	0.4	0.5	1.2	-1.1	0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.3	0.1	-0.6
Whole body fat mass	0.3	1.1	2.0	-1.0	-1.4	0.6
Leg fat mass (right)	0.0	0.2	0.5	-0.3	-0.7	-0.1
Arm predicted mass (right)	0.0	0.2	0.3	0.5	0.5	0.0
Pulse rate, automated reading	0.1	0.2	0.7	0.2	0.8	0.1
Alcohol intake frequency.	1.2	2.7	3.6	-1.9	-1.8	1.1
Comparative height size at age 10	0.1	0.4	1.1	-0.3	0.1	1.1
Number of full sisters	0.4	0.5	0.8	0.7	0.5	-0.9
Suffer from ‘nerves’	1.1	1.7	2.7	0.9	1.2	-1.6
Overall health rating	1.0	2.1	3.3	-1.8	-1.2	1.3
Chest pain or discomfort	0.4	0.6	1.1	-0.5	-1.0	-0.8
Had major operations	3.3	3.9	5.4	-2.3	-1.2	2.2
Age at last live birth	0.2	0.3	0.8	0.1	-0.9	-0.5
Family relationship satisfaction	0.8	1.0	1.5	0.9	1.2	-0.9
Leg pain on walking	0.3	0.4	1.0	-0.2	0.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	-0.6	-1.1	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.4	0.8	-0.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.0	1.0	1.3	-1.7
Medication: Aspirin	0.7	0.9	1.3	-1.2	-1.1	0.5
Supplements: Vitamin C	0.1	0.2	0.3	0.3	0.6	-0.2
Knee pain experienced in last month	0.2	0.3	0.5	-0.1	0.7	0.5
Hypertension (Self-reported)	0.4	1.0	1.3	-0.7	-1.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	0.1	0.2	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.7	-0.9	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.1	0.4	0.7
Smoking status: Previous	0.5	0.8	1.4	-1.2	-0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.8	1.7	0.7	-0.1
Whole body fat-free mass	0.0	0.2	0.7	-0.1	-0.0	0.9
Leg fat-free mass (right)	0.2	0.9	1.6	-0.7	-0.7	1.3
Arm fat percentage (left)	0.9	3.6	5.2	-2.0	-2.3	1.3
Average weekly red wine intake	0.2	0.3	0.8	-0.2	-0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.1	0.4	-0.8
Mood swings	0.1	0.1	0.4	0.6	-0.1	-0.0
Loneliness, isolation	0.0	0.0	0.1	-0.1	-0.1	0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.1	0.4	0.2
Ever had bowel cancer screening	0.2	0.2	0.3	0.5	-0.1	-0.5
Diabetes diagnosed by doctor	0.4	0.6	1.7	-1.3	-0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.4	-0.6	0.6
Friendships satisfaction	2.1	2.6	6.2	1.0	2.5	-0.9
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.3	-0.7	0.2
Commuting to job workplace: Walk	1.1	1.2	2.9	-0.8	-1.7	0.1
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.2	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	-0.8	-1.0	0.2
Medication for cholesterol	0.1	0.2	0.4	0.2	-0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.4	0.9	-0.4
Back pain experienced in last month	0.9	1.3	1.6	0.9	1.3	-1.1
Mineral and other dietary supplements	0.2	0.3	0.5	-0.6	-0.7	0.3
Breast cancer (self-reported)	1.5	1.8	3.2	-1.4	-0.5	1.8
Asthma (self-reported)	0.1	0.3	0.8	-0.1	0.9	-0.1
Osteoporosis (self-reported)	0.4	0.5	1.0	0.3	1.0	-0.6
Osteoarthritis (self-reported)	0.8	1.1	1.6	0.6	1.3	-1.1
Medication: Aspirin	0.4	0.6	1.0	-1.0	-0.8	0.3
Medication: Gliclazide	0.4	0.4	0.5	-0.6	-0.6	0.7
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.0	0.1	0.4
Smoking status: Current	0.5	0.9	1.1	1.0	1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.5	-1.0	-1.2	1.2
Whole body water mass	0.1	0.4	1.1	-0.2	-0.2	1.0
Leg predicted mass (right)	0.2	1.0	1.8	-0.8	-0.8	1.3
Arm fat mass (left)	0.3	1.2	1.7	-1.1	-1.3	0.8
Number of self-reported non-cancer illnesses	0.4	0.7	0.9	-0.9	-1.0	-0.4
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.1	0.3	-0.1
Miserableness	0.2	0.3	0.4	0.5	0.6	-0.6
Guilty feelings	0.4	0.6	1.0	-0.4	-0.7	-1.0
Wears glasses or contact lenses	5.1	5.9	7.7	-2.4	-2.8	2.1
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.7	-0.6	0.1
Hearing aid user	0.1	0.1	0.4	0.2	-0.6	0.1
Mother’s age at death	1.4	1.7	2.8	-1.4	-1.7	0.7
Financial situation satisfaction	0.5	0.7	1.3	-0.0	1.1	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	-0.5	-0.0	0.7
Commuting to job workplace: Public transport	0.9	1.1	1.6	1.3	0.8	-1.0
Eye problems/disorders: Glaucoma	1.2	1.4	2.1	0.8	1.3	-1.4
Medication: Blood pressure	0.6	1.1	1.2	-1.0	-1.0	-1.1
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.7	1.4	1.6	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	1.5	1.3	-0.2
High cholesterol (Self-reported)	0.4	0.6	1.0	-0.8	-1.0	-0.5
Medication: Bendroflumethiazide	1.5	2.3	3.3	-1.4	-1.8	1.3
Medication: Paracetamol	0.6	0.9	1.7	-0.6	-0.9	1.3
Medication: Lisinopril	0.4	0.5	0.8	0.9	-0.3	-0.8
Medication: Atorvastatin	0.1	0.1	0.3	-0.3	-0.6	0.2
Illnesses of father: High blood pressure	0.7	0.8	1.5	-1.0	-1.2	-0.2
Alcohol drinker status: Never	0.4	0.4	0.8	-0.7	-0.9	-0.1
Ever smoked	0.9	1.5	3.6	-1.0	-1.9	0.0
Basal metabolic rate	0.1	0.3	0.8	-0.2	-0.3	0.9
Leg fat percentage (left)	0.1	0.4	0.9	-0.6	-0.9	-0.2
Arm fat-free mass (left)	0.0	0.2	0.3	0.5	0.6	0.4
Number of operations (self-reported)	0.5	0.7	1.1	-1.0	0.3	1.0
Average weekly beer plus cider intake	2.3	3.3	6.3	1.6	2.5	-1.0
Irritability	0.4	0.7	1.9	-0.0	-0.4	-1.4
Risk taking	0.2	0.3	0.5	0.5	0.7	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.1	-0.3	-0.6
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	-0.7	0.4
Age started oral contraceptive pill	0.3	0.4	0.6	0.6	-0.8	-0.6
Diastolic blood pressure, automated reading	0.4	1.2	1.9	-1.3	-1.4	0.1
Ever depressed for a whole week	2.1	2.6	5.6	1.5	0.4	-2.4
Unable to work because of sickness or disability	0.0	0.0	0.1	0.1	0.1	-0.3
Commuting to job workplace: Cycle	0.3	0.3	0.7	0.5	0.8	0.1
Myopia	1.1	1.7	2.5	-1.6	-0.8	1.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.2	0.9	1.1	0.8
Cholesterol lowering medication	0.6	0.9	2.4	0.4	0.3	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	-0.4	-0.4
Pain experienced in last month	0.1	0.1	0.1	-0.3	-0.3	0.3
Supplements: Calcium	0.6	0.6	1.2	0.4	0.7	-1.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	-0.0	-1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.1	-0.6	-0.1
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	3.3	-1.5	-1.8	1.8
Heart disease (siblings)	0.3	0.3	0.6	0.1	0.8	-0.6
Alcohol drinker status: Previous	1.0	1.2	1.7	-1.0	-1.3	0.9
Pack years of smoking	1.9	2.7	3.3	-1.8	-1.6	1.5
Impedance of whole body	0.0	0.1	0.3	-0.1	-0.6	0.0
Leg fat mass (left)	0.0	0.2	0.4	-0.3	-0.6	-0.1
Arm predicted mass (left)	0.1	0.3	0.5	0.7	0.7	0.0