Best TWAS P=7.89e-28 · Best GWAS P=6.27e-38 conditioned to 1.02e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C11orf58 | 0.14 | 0.14 | lasso | 4 | 0.14 | 4.6e-16 | -10.8 | -10.9 | 7.9e-28 | -0.32 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | C11orf58 | 0.13 | 0.01 | enet | 25 | 0.01 | 3.5e-02 | 0.5 | 7.6 | 3.7e-14 | 0.37 | 0.04 | 0.22 | FALSE |
| 3 | GTEx | Liver | SOX6 | 0.51 | 0.39 | enet | 31 | 0.36 | 6.1e-11 | 7.4 | -6.8 | 9.3e-12 | -0.09 | 0.97 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf58 | 0.04 | 0.00 | blup | 33 | 0.01 | 2.1e-02 | 8.7 | 10.4 | 1.7e-25 | 0.52 | 0.02 | 0.12 | TRUE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | C11orf58 | 0.05 | 0.00 | blup | 33 | 0.02 | 3.4e-03 | -2.4 | 5.3 | 9.1e-08 | 0.27 | 0.01 | 0.03 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SOX6 | 0.12 | -0.01 | blup | 250 | 0.02 | 3.1e-02 | 5.6 | -8.4 | 3.4e-17 | 0.04 | 0.05 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf58 | 0.05 | 0.04 | enet | 5 | 0.04 | 1.8e-04 | -10.8 | 8.9 | 5.7e-19 | 0.18 | 0.13 | 0.05 | FALSE |