Hub : Genes

C11orf58

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1410 0.0350 2.0e-10 0.138 0.101 0.127 0.123 0.135 1.7e-16 2.9e-12 3.2e-15 9.7e-15 4.6e-16
2 GTEx Cells Transformed fibroblasts 0.1260 0.0540 6.9e-03 0.011 NA 0.013 NA 0.010 4.8e-02 NA 3.5e-02 NA 5.4e-02
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0412 0.0222 3.4e-03 -0.001 0.010 0.007 NA -0.001 5.1e-01 2.1e-02 4.8e-02 NA 4.7e-01
4 TCGA Lung Adenocarcinoma 0.0538 0.0319 5.3e-03 -0.001 0.018 0.012 NA 0.004 4.0e-01 3.4e-03 1.3e-02 NA 1.0e-01
5 TCGA Thyroid Carcinoma 0.0510 0.0250 7.3e-04 0.037 0.029 0.036 NA 0.035 1.4e-04 7.4e-04 1.8e-04 NA 2.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.6 1.4 0.3 -0.3 1.1 1.2 0.1
Bipolar Disorder or Schizophrenia 0.7 1.7 3.5 1.6 -0.5 0.5 1.9 -1.5
Depressed Affect (Nagel 2018) 0.8 1.8 2.8 1.6 1.7 -0.8 -0.7 -1.6
Depression (Nagel 2018) 0.6 1.0 1.4 1.1 1.2 -1.0 -0.4 -1.1
Intelligence (Savage-Jansen 2018) 1.2 3.6 6.6 1.9 -1.1 -2.6 -2.0 -1.5
Neuroticism (Nagel 2018) 0.7 1.7 7.7 0.5 2.8 0.6 -0.0 -0.5
Schizophrenia (2018) 0.9 1.9 4.1 1.8 -0.5 -0.1 1.4 -2.0
Schizophrenia vs Biploar Disorder 0.9 1.2 2.0 1.4 -1.4 0.1 0.9 -1.1
Worry (Nagel 2018) 0.5 1.0 4.2 0.5 2.1 0.6 0.4 -0.5
Alzheimer’s Disease (in mother) 0.5 0.6 1.2 -0.6 0.0 1.1 1.0 0.8
Alzheimer’s Disease (in father) 1.3 1.4 3.1 -1.5 0.4 1.1 0.5 1.8
Alzheimer’s Disease (including proxy) 1.1 1.6 2.1 -1.3 0.9 1.4 1.2 1.4
Crohns Disease (2017) 1.3 2.9 5.6 -0.9 -2.4 0.4 2.1 1.8
Irritable Bowel Disease (IBD) 0.4 0.9 2.9 -0.1 -1.2 0.3 1.7 0.2
Ulcerative Colitis (UC) 0.3 0.5 1.8 0.8 -0.0 -0.2 0.5 -1.4
Major Depression (MDD) 1.7 2.1 4.0 1.0 -0.1 -1.6 -2.0 -1.7
Reaction Time 1.4 2.6 3.5 -1.6 1.4 1.9 1.8 1.3
Verbal and Numeric Reasoning (VNR) 0.7 1.7 2.7 1.6 0.2 -1.6 -1.4 -1.1
Breast Cancer 2.0 4.9 10.3 2.3 -1.4 -3.2 -1.6 -2.1
Ovarian Cancer 1.0 1.3 3.4 0.7 -0.7 -1.9 -1.4 -0.1
Prostate Cancer 0.6 0.8 2.1 0.8 -1.4 0.9 0.4 -0.5
Age at First Birth 3.4 5.0 6.6 2.6 -1.9 -2.1 -2.4 -2.1
Bipolar Disorder (2011) 0.4 0.4 1.7 0.2 -0.5 1.3 0.4 -0.2
Body Mass Index (BMI) (2010) 0.4 0.5 1.5 -0.4 -0.5 0.7 0.3 1.2
Coronary Artery Disease (CAD) 5.4 6.5 12.9 -2.4 3.6 2.5 1.9 1.9
Crohns Disease (2012) 0.4 0.7 1.9 -0.4 -1.0 0.3 1.4 0.5
Mean Putamen Volume 0.7 0.8 2.0 -0.8 1.4 0.0 1.0 -0.2
Fasting Glucose 1.3 1.6 2.5 1.6 -1.3 -1.1 -1.1 -1.2
HbA1C 0.1 0.1 0.4 0.1 0.6 0.2 0.6 -0.0
HDL Cholesterol 0.7 1.2 2.3 -0.5 0.1 1.5 1.5 1.0
LDL Cholesterol 0.3 0.4 1.0 -0.5 1.0 0.7 0.3 0.5
Lupus 1.1 1.6 5.2 -0.5 2.3 1.0 1.2 -0.0
Neuroticism (2016) 0.6 0.8 2.3 -0.2 1.5 0.8 0.8 0.6
Primary Biliary Cirrhosis 0.5 0.7 1.8 -0.9 -0.4 0.9 1.3 0.3
Rheumatoid Arthritis 0.6 0.9 1.9 0.9 0.1 -1.3 -1.4 -0.2
Schizophrenia (2014) 1.0 2.2 4.3 2.0 -0.7 0.2 1.5 -2.1
Triglycerides 0.4 0.7 1.6 -0.6 1.3 0.7 1.1 0.1
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.9 1.0 0.0 -0.2 -1.4 -0.9
Ulcerative Colitis 0.3 0.5 0.8 -0.1 0.7 0.9 0.8 -0.6
Blood Eosinophil Count 0.1 0.7 1.8 1.1 0.3 -1.3 -0.4 -0.6
Blood Platelet Count 1.3 15.4 38.2 3.2 -6.2 -3.9 -2.4 -2.8
Blood Red Count 2.1 20.2 34.1 4.9 -2.9 -5.8 -4.6 -3.6
Blood White Count 0.5 3.5 11.7 -2.0 -1.3 0.3 -0.1 3.4
Heel T-Score 9.9 78.4 118.8 -10.9 7.6 10.4 5.3 8.9
BMI 0.5 2.8 5.2 -0.5 -1.4 -1.3 -2.3 2.2
Height 0.3 5.0 20.5 -0.1 4.5 1.7 0.7 -1.0
Waist Hip Ratio (WHR) 0.1 0.5 1.0 0.3 0.9 -1.0 -0.6 -0.2
Systolic Blood Pressure 0.9 4.5 13.5 -2.8 -0.2 1.0 0.5 3.7
Smoking Status 0.6 1.4 4.8 -1.1 -0.7 0.3 0.5 2.2
Allergy or Eczema 0.3 0.7 1.7 -1.3 0.8 -0.7 -0.5 0.6
Cardiovascular Disease 1.6 5.4 17.5 -2.8 -1.2 0.5 -0.4 4.2
Hypothyroidism (self reported) 0.5 1.2 3.2 -1.4 -0.5 0.8 -0.0 1.8
Respiratory disease 3.8 8.3 13.7 -3.7 2.6 2.3 2.8 2.9
Type 2 Diabetes (T2D) (2018) 2.2 4.1 14.8 -2.3 0.1 0.0 -0.6 3.8
Lung FEV1/FVC ratio 1.7 8.6 13.0 2.3 -3.2 -3.6 -3.6 -1.4
Lung FVC 0.4 1.9 7.5 1.3 -2.7 -0.4 -0.1 -0.4
Neuroticism 0.6 1.5 2.3 1.5 1.4 -0.8 -0.1 -1.5
Chronotype (morning person) 1.1 2.5 6.8 0.4 2.6 1.5 0.6 -1.8
Hair Pigment 1.3 37.5 104.0 8.0 4.4 -0.6 0.6 -10.2
Tanning 0.7 8.1 19.9 -3.1 -3.3 0.1 0.5 4.5
Hand grip strength (left) 0.4 1.2 1.6 -0.9 1.2 0.6 -1.3 1.2
Number of treatments/medications taken 1.1 1.9 4.6 -1.8 -0.5 1.0 0.9 2.1
Average weekly spirits intake 0.6 0.8 1.9 0.5 1.0 -0.9 -1.4 -0.3
Sensitivity / hurt feelings 0.6 1.0 3.4 -0.3 1.9 1.2 0.2 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.9 0.4 -0.6 -1.4 -1.0 0.0
Hearing difficulty/problems: Yes 0.5 0.8 1.8 -1.1 0.8 0.1 0.4 1.3
Relative age of first facial hair 2.0 4.1 12.2 2.8 0.3 -0.4 -0.6 -3.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.0 -0.2 -0.6 -1.4 -1.2 0.9
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.9 1.7 0.6 -1.6 -0.4 -2.2
Ever had hysterectomy (womb removed) 0.4 0.5 1.3 -0.2 0.6 -0.8 -1.1 -0.2
Systolic blood pressure, automated reading 0.6 1.9 5.0 -1.7 1.1 0.2 -0.0 2.2
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 5.8 -1.4 -1.4 0.5 1.0 2.4
Angina 0.8 1.0 2.4 -1.0 -1.1 0.1 0.7 1.5
Medication for hormone replacement therapy 0.2 0.2 0.3 0.4 -0.6 0.5 -0.0 -0.5
Vitamin and mineral supplements 1.4 1.9 5.1 -1.9 0.8 0.4 -0.5 2.2
Supplements: Zinc 1.1 1.2 2.7 0.7 -1.6 -0.4 -1.6 -0.2
Medication: Co-codamol 0.4 0.4 1.3 0.5 -0.6 -1.1 -0.4 -0.4
Medication: Metformin 0.5 0.7 1.5 -0.6 0.0 -0.6 -1.2 1.2
Diabetes (father) 3.2 3.9 8.6 1.5 0.1 -2.7 -2.9 -1.2
Diabetes (mother) 1.0 1.3 3.9 0.3 0.1 -1.5 -2.0 0.1
Severe depression (siblings) 0.1 0.2 0.4 -0.6 -0.4 -0.3 0.0 0.4
Pack years adult smoking proportion 3.8 5.8 8.3 -2.8 1.0 2.7 2.1 2.9
Impedance of leg (right) 0.4 1.8 3.7 0.7 1.1 0.6 1.8 -1.9
Leg fat-free mass (left) 0.3 1.3 4.1 -1.1 0.0 0.0 -1.1 2.0
Trunk fat percentage 0.3 1.1 2.8 -0.0 -1.7 -1.1 -0.9 0.7
Hand grip strength (right) 0.5 1.3 1.8 -1.2 0.8 1.0 -1.3 1.3
Townsend deprivation index at recruitment 1.2 1.7 3.9 -1.4 -1.4 -0.2 0.5 2.0
Current tobacco smoking 3.0 4.8 12.5 -2.7 -0.5 1.7 1.0 3.5
Average weekly fortified wine intake 1.5 1.7 2.7 -1.4 1.6 0.5 1.4 1.3
Maternal smoking around birth 0.5 0.7 1.9 -0.2 -1.4 -0.6 -0.6 0.9
Fed-up feelings 1.5 2.7 5.2 1.9 -1.1 -2.3 -1.5 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.0 1.0 -1.4 -0.8 0.3 -0.4
Relative age voice broke 1.0 1.5 4.7 1.5 -0.2 -0.4 -0.0 -2.2
Taking other prescription medications 0.9 1.3 2.3 -1.5 -0.1 1.3 1.3 1.0
Age when periods started (menarche) 1.9 4.6 10.2 1.8 3.0 0.9 0.4 -3.2
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 5.1 1.8 0.9 -1.0 -1.6 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 5.9 13.4 20.0 -4.2 3.4 4.5 2.7 3.2
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.0 0.5 0.5 0.5 -0.2
Qualifications: CSEs or equivalent 1.4 1.8 7.4 0.3 1.1 -0.6 -2.7 0.3
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.3 -0.1 0.7 0.4 0.5
High blood pressure 2.4 6.7 19.0 -3.5 0.9 1.4 0.3 4.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.2 -1.1 -0.3 -1.1 -0.0 0.7
Multivitamins +/- minerals 0.3 0.4 1.2 0.7 0.2 -0.3 0.4 -1.1
Stomach or abdominal pain in last month 0.4 0.5 1.0 0.2 1.0 0.7 0.8 0.5
Supplements: Glucosamine 0.3 0.4 0.5 0.7 -0.5 0.7 -0.5 -0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.5 -0.2 -0.9 0.3 1.2 0.3
Medication: Atenolol 0.8 1.0 2.7 -0.6 -0.6 1.7 1.1 0.8
Medication: Levothyroxine sodium 0.5 0.8 3.1 -0.4 0.2 1.8 0.7 0.7
Sitting height 0.9 6.4 21.6 -1.6 4.7 2.3 1.7 0.3
Chronic bronchitis/emphysema (father) 0.4 0.5 1.1 1.0 0.5 -0.2 -0.9 -0.3
High blood pressure (mother) 2.3 3.3 9.0 -2.6 -0.4 0.3 -0.4 3.0
Body mass index (BMI) 0.6 2.6 6.9 -0.9 -1.5 -0.7 -1.6 2.6
Impedance of leg (left) 0.4 1.9 3.7 0.5 1.3 0.7 1.9 -1.8
Leg predicted mass (left) 0.3 1.4 4.1 -1.2 0.1 0.0 -1.2 2.0
Trunk fat mass 0.2 1.0 2.2 -0.6 -0.9 -0.7 -1.0 1.5
Waist circumference 0.5 1.7 2.8 -0.3 -0.6 -1.6 -1.7 1.6
Number of incorrect matches in round 3.2 5.3 8.9 -2.8 2.4 1.8 0.8 3.0
Past tobacco smoking 1.1 2.0 4.8 -0.8 0.6 2.2 2.0 0.3
Alcohol usually taken with meals 0.2 0.3 0.7 -0.0 0.8 -0.6 0.2 -0.6
Nervous feelings 0.6 1.1 2.2 1.4 -0.9 0.0 0.7 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.8 0.4 -1.7 -0.7 -0.1 0.0
Hearing difficulty/problems with background noise 1.4 2.2 6.2 -1.7 -1.1 -0.6 -0.4 2.5
Hair/balding pattern: Pattern 2 0.5 0.6 1.0 1.0 0.4 -1.0 -0.6 -0.8
Had menopause 3.8 4.7 12.1 2.9 0.4 -1.7 -0.3 -3.5
Had other major operations 0.3 0.4 0.7 -0.7 0.0 0.3 0.7 0.8
Forced vital capacity (FVC) 0.1 0.3 0.4 0.6 -0.6 -0.3 -0.4 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 8.3 19.1 27.8 -5.2 3.8 5.3 3.5 3.8
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 3.6 1.8 -1.0 -1.9 -1.3 -1.7
Qualifications: None of the above 0.5 1.1 3.3 -1.1 -0.3 0.7 0.4 1.8
Financial difficulties in last 2 years 2.6 3.5 10.1 -2.5 1.0 0.3 -0.6 3.2
Mouth/teeth dental problems 0.5 0.8 2.3 0.1 -0.2 1.0 1.5 -0.7
Heart attack 1.7 2.2 5.1 -2.2 0.7 0.8 0.3 2.3
Allergy 0.4 0.9 2.7 1.6 -0.9 0.4 -0.5 -0.8
Pain all over the body in last month 1.2 1.3 3.0 0.4 -1.0 -0.7 1.4 -1.7
Diabetes (self-reported) 1.1 1.7 5.2 -1.4 0.7 -0.2 -1.0 2.3
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.1 0.5 -1.4 -1.8 -1.1 -0.7
Medication: Ramipril 1.3 1.7 4.0 0.4 -2.0 -1.8 -1.0 0.3
Medication: Simvastatin 3.7 5.5 15.7 -2.9 -0.4 1.5 1.0 4.0
Fluid intelligence score 0.7 1.4 3.1 0.9 -0.1 -1.8 -1.7 -0.2
Illnesses of siblings 0.8 1.1 2.0 0.7 -1.2 -1.4 -0.3 -1.2
Neuroticism score 0.4 0.8 1.6 1.3 0.7 -0.8 -0.5 -1.1
Weight 0.4 1.8 5.8 -1.3 0.2 0.1 -1.1 2.4
Impedance of arm (right) 1.2 5.7 17.9 2.8 -0.7 -1.4 0.7 -4.2
Arm fat percentage (right) 0.6 2.4 5.2 0.3 -2.3 -1.8 -1.6 1.1
Trunk fat-free mass 0.6 3.5 8.0 -2.1 1.9 1.4 -0.2 2.8
Hip circumference 0.2 0.6 1.5 0.2 -1.2 -0.5 -0.7 1.0
Time employed in main current job 1.4 1.6 2.4 -1.5 1.1 1.1 1.3 1.3
Alcohol intake versus 10 years previously 0.4 0.6 2.6 -0.4 -1.6 -0.1 -0.0 0.3
Father’s age at death 2.4 3.2 7.7 1.9 1.4 -1.1 -1.1 -2.8
Worrier / anxious feelings 0.1 0.2 0.8 0.1 -0.1 -0.3 -0.9 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 5.4 1.4 -2.3 -2.0 -1.5 -0.5
Falls in the last year 1.1 1.5 3.6 -1.6 -0.1 -0.6 -1.0 1.9
Hair/balding pattern: Pattern 3 0.4 0.5 1.3 -0.7 -0.1 -0.1 -1.1 0.9
Number of live births 0.3 0.5 1.0 0.9 0.5 0.3 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.2 1.8 0.9 -1.3 -1.1 -1.1 -0.8
Pulse rate 0.5 0.9 1.8 1.3 0.2 -0.8 -0.6 -1.3
Happiness 1.1 1.3 2.6 1.6 -0.9 -1.4 -0.1 -1.1
Noisy workplace 0.5 0.6 2.7 0.2 -1.7 -0.1 -0.5 0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.1 -1.1 0.0 -0.1 0.4 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.2 -0.5 -0.8 -1.1 -1.1 0.8
Mouth/teeth dental problems: Dentures 0.2 0.4 0.8 -0.0 -0.9 -0.5 -0.9 0.4
Asthma 0.9 1.7 4.6 -1.6 2.1 0.5 0.8 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.5 1.2 -0.4 0.3 0.1 -0.8
Medication: Cholesterol lowering 5.2 8.0 18.1 -3.6 -0.8 2.4 1.6 4.3
Depression (self-reported) 0.4 0.4 1.8 -0.3 -1.3 -0.4 -0.2 0.2
Medication: Lansoprazole 0.5 0.6 1.9 -0.3 1.4 0.6 0.2 0.7
Prospective memory result 0.6 0.7 2.1 0.2 -0.2 1.1 1.5 -0.6
Lung cancer (father) 0.8 0.9 2.2 -1.4 0.5 0.3 -0.5 1.5
Illnesses of mother 0.7 0.9 2.7 1.3 -0.0 -0.3 0.5 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.8 0.5 -2.2 -0.5 -0.3 -0.1
Pulse wave Arterial Stiffness index 1.7 2.0 4.4 -2.1 1.0 0.9 -0.2 1.9
Impedance of arm (left) 1.3 6.2 20.8 2.8 -0.7 -1.3 0.7 -4.6
Arm fat mass (right) 0.4 1.6 3.9 -0.6 -1.1 -0.8 -1.3 2.0
Trunk predicted mass 0.6 3.6 8.0 -2.1 1.9 1.4 -0.2 2.8
Standing height 0.4 3.8 15.1 -0.7 3.9 1.7 0.8 -0.4
Length of working week for main job 0.5 0.6 1.7 -0.6 -0.1 0.2 -0.9 1.3
Exposure to tobacco smoke at home 1.4 1.6 4.0 -1.8 -0.8 0.2 -0.3 2.0
Breastfed as a baby 2.9 3.6 6.0 2.0 -0.9 -2.4 -2.4 -1.1
Tense / ‘highly strung’ 0.9 1.6 2.5 -1.4 0.5 1.6 1.4 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.3 0.4 -0.3 0.2 -0.7
Hair/balding pattern: Pattern 4 0.1 0.1 0.4 -0.0 -0.5 0.2 -0.6 0.4
Birth weight of first child 1.3 2.4 3.6 1.6 -1.3 -1.9 -1.1 -1.7
Peak expiratory flow (PEF) 0.6 1.3 4.3 0.3 -1.0 -1.1 -2.1 -0.1
Pulse wave reflection index 2.9 3.6 7.9 -2.8 0.1 1.7 0.9 2.5
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.2 -0.0 1.8 0.2 -0.3 0.1
Loud music exposure frequency 0.7 0.7 1.8 -1.1 0.8 0.2 0.1 1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.3 -0.7 1.5 0.3 0.4 -0.3
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 4.0 0.8 0.7 -2.0 -1.6 -0.4
Blood clot in the leg (DVT) 0.3 0.3 1.5 -0.3 1.2 -0.3 -0.3 -0.1
Medication: Paracetamol 0.6 0.9 2.3 0.4 -1.2 -0.8 -1.5 -0.2
Headache pain in last month 0.4 0.7 1.4 0.1 -0.9 -0.2 -1.0 1.2
Medication for cholesterol, blood pressure or diabetes 3.9 6.4 16.2 3.3 1.6 -1.3 -1.0 -4.0
Glaucoma (self-reported) 0.7 0.8 1.7 0.1 -1.0 -0.9 -1.3 0.7
Gout (self-reported) 0.2 0.3 1.1 -0.3 -0.5 -0.3 0.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 -0.1 -0.3 1.1 0.5 0.4
Medication: Amlodipine 0.8 1.2 5.0 0.1 -2.2 -0.9 -0.1 0.1
Medication: Ventolin 100micrograms inhaler 3.8 4.9 6.9 -2.6 1.7 2.1 2.6 1.9
Birth weight 0.8 1.8 5.1 1.5 1.0 -0.8 -0.4 -2.3
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.8 0.9 -1.3 -0.4 -0.6 -0.2
High blood pressure (siblings) 1.4 2.1 4.0 -1.6 0.0 1.8 0.9 2.0
Forced vital capacity (FVC), Best measure 0.1 0.5 1.7 0.0 -1.3 0.5 0.7 0.1
Body fat percentage 0.3 1.3 2.5 -0.5 -1.6 -1.1 -0.9 1.4
Leg fat percentage (right) 0.5 2.0 6.0 -1.1 -1.0 -0.8 -1.0 2.5
Arm fat-free mass (right) 0.7 3.5 8.6 -2.2 1.7 1.0 -0.6 2.9
Exposure to tobacco smoke outside home 0.1 0.2 0.3 0.5 -0.5 0.4 0.4 -0.0
Comparative body size at age 10 1.0 2.7 8.8 -1.7 -0.4 1.3 0.2 3.0
Number of full brothers 1.1 1.4 4.4 0.7 -2.1 -1.2 -0.9 -0.2
Worry too long after embarrassment 0.3 0.5 1.7 0.0 1.3 0.1 -0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 0.4 -0.0 -0.8 -0.9 -0.5
Wheeze or whistling in the chest in last year 0.4 0.7 1.2 -1.1 0.7 0.5 0.8 1.0
Number of children fathered 1.3 1.4 3.5 1.3 -1.1 -0.7 -0.0 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 -0.3 0.6 0.6 0.0 0.5
Age at first live birth 1.2 2.2 3.7 -1.6 1.1 1.9 0.9 1.6
Pulse wave peak to peak time 1.2 1.4 3.2 1.8 -0.8 -0.6 0.3 -1.6
Health satisfaction 0.2 0.3 0.7 -0.5 -0.4 -0.4 0.2 0.8
Shortness of breath walking on level ground 0.2 0.2 0.5 -0.1 -0.5 0.2 0.7 0.4
Qualifications: College or University degree 0.3 0.9 2.4 0.4 0.1 -1.4 0.0 -1.5
Eye problems/disorders: None of the above 0.6 0.7 1.9 0.5 0.4 -1.4 -1.1 -0.4
Mouth/teeth dental problems: Loose teeth 1.4 1.7 2.3 -1.1 -1.1 1.5 1.3 1.5
Emphysema/chronic bronchitis 1.1 1.3 2.4 -1.2 0.4 1.5 1.6 0.4
Medication for pain relief, constipation, heartburn 0.4 0.6 1.1 0.5 0.8 -0.6 -0.7 -1.1
Neck or shoulder pain in last month 2.2 3.2 8.3 -2.3 0.9 1.1 0.6 2.9
Medication: Blood pressure 2.9 5.1 13.2 -3.0 -0.9 1.2 1.2 3.6
Angina (self-reported) 0.9 1.1 2.6 -1.1 -1.0 0.3 0.8 1.6
Migraine (self-reported) 0.2 0.2 1.0 0.1 -1.0 0.0 0.1 -0.4
Medication: Ibuprofen 0.4 0.5 0.8 0.7 -0.1 0.6 0.7 -0.9
Medication: Allopurinol 1.3 1.8 2.6 -0.8 1.6 1.3 1.6 1.2
Medication: Omeprazole 0.6 0.7 1.3 0.9 -0.8 -0.4 1.1 -0.9
Medication: Seretide 50 evohaler 2.0 2.3 3.9 -2.0 1.0 1.3 1.4 1.7
Mean time to correctly identify matches 0.9 1.8 2.2 -1.2 1.4 1.4 1.5 1.1
Heart disease (mother) 0.1 0.2 0.5 -0.0 0.2 -0.3 -0.7 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.0 -0.9 1.7 -0.3 0.2 -0.4
Whole body fat mass 0.3 1.4 4.1 -1.0 -1.0 -0.4 -0.8 2.0
Leg fat mass (right) 0.6 2.5 8.1 -1.6 -0.6 -0.4 -1.1 2.9
Arm predicted mass (right) 0.7 3.7 8.5 -2.3 1.7 1.4 -0.2 2.9
Pulse rate, automated reading 0.2 0.8 1.6 -1.1 -0.5 0.7 1.3 0.7
Alcohol intake frequency. 0.5 1.2 2.6 -0.8 -1.4 0.4 -0.8 1.6
Comparative height size at age 10 0.8 4.2 6.1 -2.5 0.6 1.9 2.3 2.4
Number of full sisters 0.2 0.3 0.5 0.2 -0.7 -0.7 -0.2 -0.5
Suffer from ‘nerves’ 0.9 1.4 4.1 0.9 -0.5 1.0 2.0 -0.8
Overall health rating 0.8 1.7 6.1 -1.4 -0.5 -0.4 -0.5 2.5
Chest pain or discomfort 1.2 1.7 5.9 -1.1 2.4 0.4 0.9 0.6
Had major operations 0.6 0.7 1.9 -0.4 -1.4 -0.9 -0.4 0.4
Age at last live birth 1.8 2.6 4.8 -2.2 1.6 1.6 0.9 1.6
Family relationship satisfaction 1.0 1.3 2.1 1.0 -1.3 -1.2 -1.5 -0.3
Leg pain on walking 1.5 1.9 3.3 1.5 -0.8 -1.3 -1.3 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 0.5 -0.5 0.1 -1.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.1 0.6 1.1 0.5 0.3 -0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.9 0.3 -0.4 0.8 1.4 -0.6
Medication: Aspirin 2.9 3.9 8.7 -2.8 -0.5 1.4 0.8 3.0
Supplements: Vitamin C 0.4 0.5 1.5 0.5 -1.2 -0.2 -0.7 -0.2
Knee pain experienced in last month 1.5 2.3 7.4 -1.6 0.6 -0.0 -1.1 2.7
Hypertension (Self-reported) 1.8 5.1 14.7 -3.0 0.6 1.1 0.5 3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.7 0.3 -0.0 0.7 0.5 -0.8
Illnesses of father: Heart disease 0.8 1.1 2.3 -1.5 -0.4 0.5 0.8 1.5
Illnesses of siblings: Diabetes 1.1 1.3 3.1 0.8 0.7 -1.5 -1.8 0.3
Smoking status: Previous 2.2 3.3 7.3 1.6 -0.5 -2.7 -2.1 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.1 -0.0 -0.6 1.0 1.1 0.4
Whole body fat-free mass 0.5 2.8 7.6 -1.9 1.2 1.0 -0.5 2.8
Leg fat-free mass (right) 0.3 1.4 4.0 -1.2 0.2 0.1 -1.2 2.0
Arm fat percentage (left) 0.5 2.2 4.9 0.2 -2.2 -1.6 -1.5 1.0
Average weekly red wine intake 0.2 0.4 0.8 -0.3 0.9 0.1 0.9 -0.2
Handedness (chirality/laterality): Left-handed 1.9 2.2 3.7 -1.9 1.3 1.2 1.3 1.7
Mood swings 0.5 0.9 1.8 1.0 0.5 -0.9 -1.3 -0.6
Loneliness, isolation 1.2 1.7 3.1 -1.1 -1.2 1.2 1.8 1.1
Long-standing illness, disability or infirmity 0.5 0.8 2.6 0.1 -1.6 -1.0 -0.6 0.3
Ever had bowel cancer screening 1.5 1.8 3.4 -1.5 1.9 0.6 1.1 1.3
Diabetes diagnosed by doctor 1.4 2.3 7.2 -1.9 0.5 0.0 -0.6 2.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 -0.8 0.7 -0.0 0.8 0.6
Friendships satisfaction 1.8 2.3 4.9 1.9 -2.2 -1.2 -0.5 -1.2
Qualifications: nursing, teaching 0.1 0.2 0.4 -0.6 0.7 -0.3 0.1 0.4
Commuting to job workplace: Walk 1.5 1.6 3.0 1.4 -0.8 -1.7 -0.6 -1.5
Eye problems/disorders: Cataract 0.9 1.0 2.9 -0.4 0.7 1.3 1.7 -0.0
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 3.9 1.2 -0.7 -1.8 -2.0 -0.4
Medication for cholesterol 1.3 1.9 5.7 1.5 0.2 -1.1 -0.6 -2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.3 -0.3 -1.1 0.9 0.2 0.7
Back pain experienced in last month 0.4 0.7 2.0 0.5 1.4 0.1 -1.0 -0.0
Mineral and other dietary supplements 2.4 3.2 8.0 -2.4 1.5 0.1 -0.2 2.8
Breast cancer (self-reported) 1.7 2.1 3.8 -1.8 0.6 1.9 0.9 1.5
Asthma (self-reported) 1.1 2.3 5.9 -1.7 2.4 0.7 1.0 1.1
Osteoporosis (self-reported) 4.9 6.0 9.6 3.1 -1.8 -2.6 -1.4 -2.9
Osteoarthritis (self-reported) 0.8 1.0 3.3 -0.6 0.5 -0.9 -1.8 0.5
Medication: Aspirin 2.3 3.0 7.8 -2.4 -0.3 1.1 0.3 2.8
Medication: Gliclazide 0.0 0.0 0.0 0.1 -0.0 -0.1 -0.1 0.0
Illnesses of father: None of the above (group 1) 0.9 1.1 3.0 1.3 0.2 -0.7 -0.5 -1.7
Smoking status: Current 3.2 5.2 12.7 -2.7 -0.9 1.7 1.3 3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 10.2 -1.1 -3.2 1.1 1.2 1.4
Whole body water mass 0.4 2.6 7.1 -1.8 1.1 0.9 -0.5 2.7
Leg predicted mass (right) 0.3 1.4 4.2 -1.3 0.2 0.2 -1.1 2.0
Arm fat mass (left) 0.4 1.5 3.7 -0.7 -1.2 -0.8 -1.2 1.9
Number of self-reported non-cancer illnesses 1.9 3.3 5.4 -2.3 1.9 1.2 0.9 2.3
Average weekly champagne plus white wine intake 0.7 0.9 3.0 0.5 -0.1 0.6 1.7 -1.0
Miserableness 1.6 2.8 4.9 1.8 -0.1 -2.0 -2.2 -1.4
Guilty feelings 0.1 0.1 0.4 -0.0 0.6 0.2 0.1 -0.3
Wears glasses or contact lenses 0.2 0.3 0.6 -0.8 0.7 -0.2 -0.2 0.4
Ever taken oral contraceptive pill 0.6 0.7 1.5 0.0 -1.2 0.5 1.2 0.5
Hearing aid user 7.0 7.9 10.8 -3.3 3.1 2.6 1.6 3.1
Mother’s age at death 0.6 0.8 1.7 0.5 0.6 -1.0 -1.3 -0.8
Financial situation satisfaction 0.1 0.1 0.5 -0.0 0.1 -0.7 0.1 -0.1
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.4 -1.4 -0.5 0.9 0.3 1.8
Commuting to job workplace: Public transport 0.3 0.4 0.7 -0.8 -0.5 -0.1 0.8 0.5
Eye problems/disorders: Glaucoma 0.5 0.6 1.3 -0.2 -1.1 -0.5 -0.9 0.8
Medication: Blood pressure 0.9 1.7 4.1 -1.6 0.5 0.9 0.8 2.0
Pain type(s) experienced in last month: Hip pain 1.6 2.1 5.0 1.1 0.5 -1.9 -2.2 -0.3
Supplements: Fish oil (including cod liver oil) 2.4 3.2 6.9 2.4 -1.6 -0.6 -0.3 -2.6
High cholesterol (Self-reported) 2.5 4.4 10.6 -2.5 0.2 2.0 1.2 3.2
Medication: Bendroflumethiazide 5.9 9.0 17.0 -3.9 1.5 2.6 2.0 4.1
Medication: Paracetamol 0.4 0.6 2.5 0.0 -1.6 -0.5 -0.6 0.0
Medication: Lisinopril 3.2 4.1 8.1 -2.6 0.3 2.3 0.5 2.8
Medication: Atorvastatin 1.4 1.8 3.1 -1.6 0.5 1.4 0.9 1.8
Illnesses of father: High blood pressure 2.1 2.6 4.5 -2.1 -1.7 0.7 0.9 2.1
Alcohol drinker status: Never 0.6 0.7 1.6 -0.8 -1.0 -0.4 -0.5 1.3
Ever smoked 0.8 1.5 3.4 0.6 -0.4 -1.8 -1.8 0.1
Basal metabolic rate 0.4 2.2 6.9 -1.7 0.8 0.7 -0.7 2.6
Leg fat percentage (left) 0.6 2.1 7.1 -1.3 -0.8 -0.6 -0.9 2.7
Arm fat-free mass (left) 0.8 4.0 11.0 -2.3 1.4 1.2 -0.3 3.3
Number of operations (self-reported) 0.9 1.4 3.1 0.7 -0.2 -1.8 -1.6 -0.8
Average weekly beer plus cider intake 0.7 1.0 3.2 -1.0 -1.8 0.1 0.0 0.8
Irritability 0.1 0.2 0.4 0.5 0.6 0.2 -0.5 -0.3
Risk taking 0.1 0.1 0.2 0.4 -0.1 -0.2 -0.5 -0.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.7 -0.1 0.8 -0.0 -0.3 0.4
Fractured/broken bones in last 5 years 6.4 8.3 12.0 2.7 -3.1 -3.3 -3.5 -1.4
Age started oral contraceptive pill 0.6 0.8 2.8 0.1 1.7 -0.8 0.4 -0.7
Diastolic blood pressure, automated reading 0.4 1.1 2.1 -1.4 0.7 0.7 0.7 1.5
Ever depressed for a whole week 0.2 0.2 0.6 0.1 -0.1 -0.8 0.3 -0.5
Unable to work because of sickness or disability 3.9 5.0 14.6 -2.9 -1.2 0.5 0.5 3.8
Commuting to job workplace: Cycle 2.6 3.1 5.4 -1.7 0.7 2.3 2.2 1.4
Myopia 0.4 0.6 1.3 0.4 -0.9 -1.2 0.2 -0.8
Vascular/heart problems diagnosed by doctor 2.2 6.0 17.5 3.3 -0.4 -1.1 0.0 -4.2
Cholesterol lowering medication 1.2 1.8 6.2 -1.3 0.8 0.6 0.4 2.5
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.8 0.7 -0.9 0.2 1.7 -0.5
Pain experienced in last month 0.3 0.5 1.2 -0.0 -1.1 -0.4 0.4 -0.9
Supplements: Calcium 1.3 1.5 2.9 1.6 -1.7 -0.8 -0.7 -1.0
Basal cell carcinoma (self-reported) 0.5 0.6 2.1 -0.3 1.4 0.4 0.5 -0.6
Heart attack/myocardial infarction (self-reported) 1.8 2.4 5.3 -2.2 0.7 1.0 0.4 2.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 -0.0 1.0 -0.5 -0.7 -0.3
Heart disease (siblings) 1.0 1.2 4.7 -0.4 2.2 1.0 0.3 0.2
Alcohol drinker status: Previous 0.3 0.4 1.1 -0.5 -0.4 -0.1 -0.6 1.1
Pack years of smoking 2.8 4.1 6.6 -2.2 0.9 2.6 2.0 2.1
Impedance of whole body 0.7 3.6 12.3 1.8 0.3 -0.3 1.6 -3.5
Leg fat mass (left) 0.7 2.5 8.6 -1.6 -0.6 -0.3 -1.0 2.9
Arm predicted mass (left) 0.7 3.8 10.8 -2.2 1.4 1.0 -0.6 3.3