Hub : Genes

C11orf58

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1410	0.0350	2.0e-10	0.138	0.101	0.127	0.123	0.135	1.7e-16	2.9e-12	3.2e-15	9.7e-15	4.6e-16
2	GTEx	Cells Transformed fibroblasts	0.1260	0.0540	6.9e-03	0.011	NA	0.013	NA	0.010	4.8e-02	NA	3.5e-02	NA	5.4e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0412	0.0222	3.4e-03	-0.001	0.010	0.007	NA	-0.001	5.1e-01	2.1e-02	4.8e-02	NA	4.7e-01
4	TCGA	Lung Adenocarcinoma	0.0538	0.0319	5.3e-03	-0.001	0.018	0.012	NA	0.004	4.0e-01	3.4e-03	1.3e-02	NA	1.0e-01
5	TCGA	Thyroid Carcinoma	0.0510	0.0250	7.3e-04	0.037	0.029	0.036	NA	0.035	1.4e-04	7.4e-04	1.8e-04	NA	2.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.4	0.3	-0.3	1.1	1.2	0.1
Bipolar Disorder or Schizophrenia	0.7	1.7	3.5	1.6	-0.5	0.5	1.9	-1.5
Depressed Affect (Nagel 2018)	0.8	1.8	2.8	1.6	1.7	-0.8	-0.7	-1.6
Depression (Nagel 2018)	0.6	1.0	1.4	1.1	1.2	-1.0	-0.4	-1.1
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.6	1.9	-1.1	-2.6	-2.0	-1.5
Neuroticism (Nagel 2018)	0.7	1.7	7.7	0.5	2.8	0.6	-0.0	-0.5
Schizophrenia (2018)	0.9	1.9	4.1	1.8	-0.5	-0.1	1.4	-2.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.0	1.4	-1.4	0.1	0.9	-1.1
Worry (Nagel 2018)	0.5	1.0	4.2	0.5	2.1	0.6	0.4	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	-0.6	0.0	1.1	1.0	0.8
Alzheimer’s Disease (in father)	1.3	1.4	3.1	-1.5	0.4	1.1	0.5	1.8
Alzheimer’s Disease (including proxy)	1.1	1.6	2.1	-1.3	0.9	1.4	1.2	1.4
Crohns Disease (2017)	1.3	2.9	5.6	-0.9	-2.4	0.4	2.1	1.8
Irritable Bowel Disease (IBD)	0.4	0.9	2.9	-0.1	-1.2	0.3	1.7	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.8	0.8	-0.0	-0.2	0.5	-1.4
Major Depression (MDD)	1.7	2.1	4.0	1.0	-0.1	-1.6	-2.0	-1.7
Reaction Time	1.4	2.6	3.5	-1.6	1.4	1.9	1.8	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.7	1.6	0.2	-1.6	-1.4	-1.1
Breast Cancer	2.0	4.9	10.3	2.3	-1.4	-3.2	-1.6	-2.1
Ovarian Cancer	1.0	1.3	3.4	0.7	-0.7	-1.9	-1.4	-0.1
Prostate Cancer	0.6	0.8	2.1	0.8	-1.4	0.9	0.4	-0.5
Age at First Birth	3.4	5.0	6.6	2.6	-1.9	-2.1	-2.4	-2.1
Bipolar Disorder (2011)	0.4	0.4	1.7	0.2	-0.5	1.3	0.4	-0.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.5	-0.4	-0.5	0.7	0.3	1.2
Coronary Artery Disease (CAD)	5.4	6.5	12.9	-2.4	3.6	2.5	1.9	1.9
Crohns Disease (2012)	0.4	0.7	1.9	-0.4	-1.0	0.3	1.4	0.5
Mean Putamen Volume	0.7	0.8	2.0	-0.8	1.4	0.0	1.0	-0.2
Fasting Glucose	1.3	1.6	2.5	1.6	-1.3	-1.1	-1.1	-1.2
HbA1C	0.1	0.1	0.4	0.1	0.6	0.2	0.6	-0.0
HDL Cholesterol	0.7	1.2	2.3	-0.5	0.1	1.5	1.5	1.0
LDL Cholesterol	0.3	0.4	1.0	-0.5	1.0	0.7	0.3	0.5
Lupus	1.1	1.6	5.2	-0.5	2.3	1.0	1.2	-0.0
Neuroticism (2016)	0.6	0.8	2.3	-0.2	1.5	0.8	0.8	0.6
Primary Biliary Cirrhosis	0.5	0.7	1.8	-0.9	-0.4	0.9	1.3	0.3
Rheumatoid Arthritis	0.6	0.9	1.9	0.9	0.1	-1.3	-1.4	-0.2
Schizophrenia (2014)	1.0	2.2	4.3	2.0	-0.7	0.2	1.5	-2.1
Triglycerides	0.4	0.7	1.6	-0.6	1.3	0.7	1.1	0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	1.0	0.0	-0.2	-1.4	-0.9
Ulcerative Colitis	0.3	0.5	0.8	-0.1	0.7	0.9	0.8	-0.6
Blood Eosinophil Count	0.1	0.7	1.8	1.1	0.3	-1.3	-0.4	-0.6
Blood Platelet Count	1.3	15.4	38.2	3.2	-6.2	-3.9	-2.4	-2.8
Blood Red Count	2.1	20.2	34.1	4.9	-2.9	-5.8	-4.6	-3.6
Blood White Count	0.5	3.5	11.7	-2.0	-1.3	0.3	-0.1	3.4
Heel T-Score	9.9	78.4	118.8	-10.9	7.6	10.4	5.3	8.9
BMI	0.5	2.8	5.2	-0.5	-1.4	-1.3	-2.3	2.2
Height	0.3	5.0	20.5	-0.1	4.5	1.7	0.7	-1.0
Waist Hip Ratio (WHR)	0.1	0.5	1.0	0.3	0.9	-1.0	-0.6	-0.2
Systolic Blood Pressure	0.9	4.5	13.5	-2.8	-0.2	1.0	0.5	3.7
Smoking Status	0.6	1.4	4.8	-1.1	-0.7	0.3	0.5	2.2
Allergy or Eczema	0.3	0.7	1.7	-1.3	0.8	-0.7	-0.5	0.6
Cardiovascular Disease	1.6	5.4	17.5	-2.8	-1.2	0.5	-0.4	4.2
Hypothyroidism (self reported)	0.5	1.2	3.2	-1.4	-0.5	0.8	-0.0	1.8
Respiratory disease	3.8	8.3	13.7	-3.7	2.6	2.3	2.8	2.9
Type 2 Diabetes (T2D) (2018)	2.2	4.1	14.8	-2.3	0.1	0.0	-0.6	3.8
Lung FEV1/FVC ratio	1.7	8.6	13.0	2.3	-3.2	-3.6	-3.6	-1.4
Lung FVC	0.4	1.9	7.5	1.3	-2.7	-0.4	-0.1	-0.4
Neuroticism	0.6	1.5	2.3	1.5	1.4	-0.8	-0.1	-1.5
Chronotype (morning person)	1.1	2.5	6.8	0.4	2.6	1.5	0.6	-1.8
Hair Pigment	1.3	37.5	104.0	8.0	4.4	-0.6	0.6	-10.2
Tanning	0.7	8.1	19.9	-3.1	-3.3	0.1	0.5	4.5
Hand grip strength (left)	0.4	1.2	1.6	-0.9	1.2	0.6	-1.3	1.2
Number of treatments/medications taken	1.1	1.9	4.6	-1.8	-0.5	1.0	0.9	2.1
Average weekly spirits intake	0.6	0.8	1.9	0.5	1.0	-0.9	-1.4	-0.3
Sensitivity / hurt feelings	0.6	1.0	3.4	-0.3	1.9	1.2	0.2	0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	0.4	-0.6	-1.4	-1.0	0.0
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-1.1	0.8	0.1	0.4	1.3
Relative age of first facial hair	2.0	4.1	12.2	2.8	0.3	-0.4	-0.6	-3.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.0	-0.2	-0.6	-1.4	-1.2	0.9
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.9	1.7	0.6	-1.6	-0.4	-2.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-0.2	0.6	-0.8	-1.1	-0.2
Systolic blood pressure, automated reading	0.6	1.9	5.0	-1.7	1.1	0.2	-0.0	2.2
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.8	-1.4	-1.4	0.5	1.0	2.4
Angina	0.8	1.0	2.4	-1.0	-1.1	0.1	0.7	1.5
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	-0.6	0.5	-0.0	-0.5
Vitamin and mineral supplements	1.4	1.9	5.1	-1.9	0.8	0.4	-0.5	2.2
Supplements: Zinc	1.1	1.2	2.7	0.7	-1.6	-0.4	-1.6	-0.2
Medication: Co-codamol	0.4	0.4	1.3	0.5	-0.6	-1.1	-0.4	-0.4
Medication: Metformin	0.5	0.7	1.5	-0.6	0.0	-0.6	-1.2	1.2
Diabetes (father)	3.2	3.9	8.6	1.5	0.1	-2.7	-2.9	-1.2
Diabetes (mother)	1.0	1.3	3.9	0.3	0.1	-1.5	-2.0	0.1
Severe depression (siblings)	0.1	0.2	0.4	-0.6	-0.4	-0.3	0.0	0.4
Pack years adult smoking proportion	3.8	5.8	8.3	-2.8	1.0	2.7	2.1	2.9
Impedance of leg (right)	0.4	1.8	3.7	0.7	1.1	0.6	1.8	-1.9
Leg fat-free mass (left)	0.3	1.3	4.1	-1.1	0.0	0.0	-1.1	2.0
Trunk fat percentage	0.3	1.1	2.8	-0.0	-1.7	-1.1	-0.9	0.7
Hand grip strength (right)	0.5	1.3	1.8	-1.2	0.8	1.0	-1.3	1.3
Townsend deprivation index at recruitment	1.2	1.7	3.9	-1.4	-1.4	-0.2	0.5	2.0
Current tobacco smoking	3.0	4.8	12.5	-2.7	-0.5	1.7	1.0	3.5
Average weekly fortified wine intake	1.5	1.7	2.7	-1.4	1.6	0.5	1.4	1.3
Maternal smoking around birth	0.5	0.7	1.9	-0.2	-1.4	-0.6	-0.6	0.9
Fed-up feelings	1.5	2.7	5.2	1.9	-1.1	-2.3	-1.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	1.0	-1.4	-0.8	0.3	-0.4
Relative age voice broke	1.0	1.5	4.7	1.5	-0.2	-0.4	-0.0	-2.2
Taking other prescription medications	0.9	1.3	2.3	-1.5	-0.1	1.3	1.3	1.0
Age when periods started (menarche)	1.9	4.6	10.2	1.8	3.0	0.9	0.4	-3.2
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	5.1	1.8	0.9	-1.0	-1.6	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	5.9	13.4	20.0	-4.2	3.4	4.5	2.7	3.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.0	0.5	0.5	0.5	-0.2
Qualifications: CSEs or equivalent	1.4	1.8	7.4	0.3	1.1	-0.6	-2.7	0.3
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.3	-0.1	0.7	0.4	0.5
High blood pressure	2.4	6.7	19.0	-3.5	0.9	1.4	0.3	4.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-1.1	-0.3	-1.1	-0.0	0.7
Multivitamins +/- minerals	0.3	0.4	1.2	0.7	0.2	-0.3	0.4	-1.1
Stomach or abdominal pain in last month	0.4	0.5	1.0	0.2	1.0	0.7	0.8	0.5
Supplements: Glucosamine	0.3	0.4	0.5	0.7	-0.5	0.7	-0.5	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.5	-0.2	-0.9	0.3	1.2	0.3
Medication: Atenolol	0.8	1.0	2.7	-0.6	-0.6	1.7	1.1	0.8
Medication: Levothyroxine sodium	0.5	0.8	3.1	-0.4	0.2	1.8	0.7	0.7
Sitting height	0.9	6.4	21.6	-1.6	4.7	2.3	1.7	0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	1.0	0.5	-0.2	-0.9	-0.3
High blood pressure (mother)	2.3	3.3	9.0	-2.6	-0.4	0.3	-0.4	3.0
Body mass index (BMI)	0.6	2.6	6.9	-0.9	-1.5	-0.7	-1.6	2.6
Impedance of leg (left)	0.4	1.9	3.7	0.5	1.3	0.7	1.9	-1.8
Leg predicted mass (left)	0.3	1.4	4.1	-1.2	0.1	0.0	-1.2	2.0
Trunk fat mass	0.2	1.0	2.2	-0.6	-0.9	-0.7	-1.0	1.5
Waist circumference	0.5	1.7	2.8	-0.3	-0.6	-1.6	-1.7	1.6
Number of incorrect matches in round	3.2	5.3	8.9	-2.8	2.4	1.8	0.8	3.0
Past tobacco smoking	1.1	2.0	4.8	-0.8	0.6	2.2	2.0	0.3
Alcohol usually taken with meals	0.2	0.3	0.7	-0.0	0.8	-0.6	0.2	-0.6
Nervous feelings	0.6	1.1	2.2	1.4	-0.9	0.0	0.7	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.8	0.4	-1.7	-0.7	-0.1	0.0
Hearing difficulty/problems with background noise	1.4	2.2	6.2	-1.7	-1.1	-0.6	-0.4	2.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	1.0	0.4	-1.0	-0.6	-0.8
Had menopause	3.8	4.7	12.1	2.9	0.4	-1.7	-0.3	-3.5
Had other major operations	0.3	0.4	0.7	-0.7	0.0	0.3	0.7	0.8
Forced vital capacity (FVC)	0.1	0.3	0.4	0.6	-0.6	-0.3	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	8.3	19.1	27.8	-5.2	3.8	5.3	3.5	3.8
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.6	1.8	-1.0	-1.9	-1.3	-1.7
Qualifications: None of the above	0.5	1.1	3.3	-1.1	-0.3	0.7	0.4	1.8
Financial difficulties in last 2 years	2.6	3.5	10.1	-2.5	1.0	0.3	-0.6	3.2
Mouth/teeth dental problems	0.5	0.8	2.3	0.1	-0.2	1.0	1.5	-0.7
Heart attack	1.7	2.2	5.1	-2.2	0.7	0.8	0.3	2.3
Allergy	0.4	0.9	2.7	1.6	-0.9	0.4	-0.5	-0.8
Pain all over the body in last month	1.2	1.3	3.0	0.4	-1.0	-0.7	1.4	-1.7
Diabetes (self-reported)	1.1	1.7	5.2	-1.4	0.7	-0.2	-1.0	2.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.1	0.5	-1.4	-1.8	-1.1	-0.7
Medication: Ramipril	1.3	1.7	4.0	0.4	-2.0	-1.8	-1.0	0.3
Medication: Simvastatin	3.7	5.5	15.7	-2.9	-0.4	1.5	1.0	4.0
Fluid intelligence score	0.7	1.4	3.1	0.9	-0.1	-1.8	-1.7	-0.2
Illnesses of siblings	0.8	1.1	2.0	0.7	-1.2	-1.4	-0.3	-1.2
Neuroticism score	0.4	0.8	1.6	1.3	0.7	-0.8	-0.5	-1.1
Weight	0.4	1.8	5.8	-1.3	0.2	0.1	-1.1	2.4
Impedance of arm (right)	1.2	5.7	17.9	2.8	-0.7	-1.4	0.7	-4.2
Arm fat percentage (right)	0.6	2.4	5.2	0.3	-2.3	-1.8	-1.6	1.1
Trunk fat-free mass	0.6	3.5	8.0	-2.1	1.9	1.4	-0.2	2.8
Hip circumference	0.2	0.6	1.5	0.2	-1.2	-0.5	-0.7	1.0
Time employed in main current job	1.4	1.6	2.4	-1.5	1.1	1.1	1.3	1.3
Alcohol intake versus 10 years previously	0.4	0.6	2.6	-0.4	-1.6	-0.1	-0.0	0.3
Father’s age at death	2.4	3.2	7.7	1.9	1.4	-1.1	-1.1	-2.8
Worrier / anxious feelings	0.1	0.2	0.8	0.1	-0.1	-0.3	-0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	5.4	1.4	-2.3	-2.0	-1.5	-0.5
Falls in the last year	1.1	1.5	3.6	-1.6	-0.1	-0.6	-1.0	1.9
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	-0.7	-0.1	-0.1	-1.1	0.9
Number of live births	0.3	0.5	1.0	0.9	0.5	0.3	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	1.8	0.9	-1.3	-1.1	-1.1	-0.8
Pulse rate	0.5	0.9	1.8	1.3	0.2	-0.8	-0.6	-1.3
Happiness	1.1	1.3	2.6	1.6	-0.9	-1.4	-0.1	-1.1
Noisy workplace	0.5	0.6	2.7	0.2	-1.7	-0.1	-0.5	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.1	-1.1	0.0	-0.1	0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-0.5	-0.8	-1.1	-1.1	0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	-0.0	-0.9	-0.5	-0.9	0.4
Asthma	0.9	1.7	4.6	-1.6	2.1	0.5	0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	1.2	-0.4	0.3	0.1	-0.8
Medication: Cholesterol lowering	5.2	8.0	18.1	-3.6	-0.8	2.4	1.6	4.3
Depression (self-reported)	0.4	0.4	1.8	-0.3	-1.3	-0.4	-0.2	0.2
Medication: Lansoprazole	0.5	0.6	1.9	-0.3	1.4	0.6	0.2	0.7
Prospective memory result	0.6	0.7	2.1	0.2	-0.2	1.1	1.5	-0.6
Lung cancer (father)	0.8	0.9	2.2	-1.4	0.5	0.3	-0.5	1.5
Illnesses of mother	0.7	0.9	2.7	1.3	-0.0	-0.3	0.5	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.8	0.5	-2.2	-0.5	-0.3	-0.1
Pulse wave Arterial Stiffness index	1.7	2.0	4.4	-2.1	1.0	0.9	-0.2	1.9
Impedance of arm (left)	1.3	6.2	20.8	2.8	-0.7	-1.3	0.7	-4.6
Arm fat mass (right)	0.4	1.6	3.9	-0.6	-1.1	-0.8	-1.3	2.0
Trunk predicted mass	0.6	3.6	8.0	-2.1	1.9	1.4	-0.2	2.8
Standing height	0.4	3.8	15.1	-0.7	3.9	1.7	0.8	-0.4
Length of working week for main job	0.5	0.6	1.7	-0.6	-0.1	0.2	-0.9	1.3
Exposure to tobacco smoke at home	1.4	1.6	4.0	-1.8	-0.8	0.2	-0.3	2.0
Breastfed as a baby	2.9	3.6	6.0	2.0	-0.9	-2.4	-2.4	-1.1
Tense / ‘highly strung’	0.9	1.6	2.5	-1.4	0.5	1.6	1.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.3	0.4	-0.3	0.2	-0.7
Hair/balding pattern: Pattern 4	0.1	0.1	0.4	-0.0	-0.5	0.2	-0.6	0.4
Birth weight of first child	1.3	2.4	3.6	1.6	-1.3	-1.9	-1.1	-1.7
Peak expiratory flow (PEF)	0.6	1.3	4.3	0.3	-1.0	-1.1	-2.1	-0.1
Pulse wave reflection index	2.9	3.6	7.9	-2.8	0.1	1.7	0.9	2.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.2	-0.0	1.8	0.2	-0.3	0.1
Loud music exposure frequency	0.7	0.7	1.8	-1.1	0.8	0.2	0.1	1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	-0.7	1.5	0.3	0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.0	0.8	0.7	-2.0	-1.6	-0.4
Blood clot in the leg (DVT)	0.3	0.3	1.5	-0.3	1.2	-0.3	-0.3	-0.1
Medication: Paracetamol	0.6	0.9	2.3	0.4	-1.2	-0.8	-1.5	-0.2
Headache pain in last month	0.4	0.7	1.4	0.1	-0.9	-0.2	-1.0	1.2
Medication for cholesterol, blood pressure or diabetes	3.9	6.4	16.2	3.3	1.6	-1.3	-1.0	-4.0
Glaucoma (self-reported)	0.7	0.8	1.7	0.1	-1.0	-0.9	-1.3	0.7
Gout (self-reported)	0.2	0.3	1.1	-0.3	-0.5	-0.3	0.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-0.1	-0.3	1.1	0.5	0.4
Medication: Amlodipine	0.8	1.2	5.0	0.1	-2.2	-0.9	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	3.8	4.9	6.9	-2.6	1.7	2.1	2.6	1.9
Birth weight	0.8	1.8	5.1	1.5	1.0	-0.8	-0.4	-2.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.8	0.9	-1.3	-0.4	-0.6	-0.2
High blood pressure (siblings)	1.4	2.1	4.0	-1.6	0.0	1.8	0.9	2.0
Forced vital capacity (FVC), Best measure	0.1	0.5	1.7	0.0	-1.3	0.5	0.7	0.1
Body fat percentage	0.3	1.3	2.5	-0.5	-1.6	-1.1	-0.9	1.4
Leg fat percentage (right)	0.5	2.0	6.0	-1.1	-1.0	-0.8	-1.0	2.5
Arm fat-free mass (right)	0.7	3.5	8.6	-2.2	1.7	1.0	-0.6	2.9
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.5	-0.5	0.4	0.4	-0.0
Comparative body size at age 10	1.0	2.7	8.8	-1.7	-0.4	1.3	0.2	3.0
Number of full brothers	1.1	1.4	4.4	0.7	-2.1	-1.2	-0.9	-0.2
Worry too long after embarrassment	0.3	0.5	1.7	0.0	1.3	0.1	-0.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.4	-0.0	-0.8	-0.9	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-1.1	0.7	0.5	0.8	1.0
Number of children fathered	1.3	1.4	3.5	1.3	-1.1	-0.7	-0.0	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.3	0.6	0.6	0.0	0.5
Age at first live birth	1.2	2.2	3.7	-1.6	1.1	1.9	0.9	1.6
Pulse wave peak to peak time	1.2	1.4	3.2	1.8	-0.8	-0.6	0.3	-1.6
Health satisfaction	0.2	0.3	0.7	-0.5	-0.4	-0.4	0.2	0.8
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.1	-0.5	0.2	0.7	0.4
Qualifications: College or University degree	0.3	0.9	2.4	0.4	0.1	-1.4	0.0	-1.5
Eye problems/disorders: None of the above	0.6	0.7	1.9	0.5	0.4	-1.4	-1.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.3	-1.1	-1.1	1.5	1.3	1.5
Emphysema/chronic bronchitis	1.1	1.3	2.4	-1.2	0.4	1.5	1.6	0.4
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	0.5	0.8	-0.6	-0.7	-1.1
Neck or shoulder pain in last month	2.2	3.2	8.3	-2.3	0.9	1.1	0.6	2.9
Medication: Blood pressure	2.9	5.1	13.2	-3.0	-0.9	1.2	1.2	3.6
Angina (self-reported)	0.9	1.1	2.6	-1.1	-1.0	0.3	0.8	1.6
Migraine (self-reported)	0.2	0.2	1.0	0.1	-1.0	0.0	0.1	-0.4
Medication: Ibuprofen	0.4	0.5	0.8	0.7	-0.1	0.6	0.7	-0.9
Medication: Allopurinol	1.3	1.8	2.6	-0.8	1.6	1.3	1.6	1.2
Medication: Omeprazole	0.6	0.7	1.3	0.9	-0.8	-0.4	1.1	-0.9
Medication: Seretide 50 evohaler	2.0	2.3	3.9	-2.0	1.0	1.3	1.4	1.7
Mean time to correctly identify matches	0.9	1.8	2.2	-1.2	1.4	1.4	1.5	1.1
Heart disease (mother)	0.1	0.2	0.5	-0.0	0.2	-0.3	-0.7	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.0	-0.9	1.7	-0.3	0.2	-0.4
Whole body fat mass	0.3	1.4	4.1	-1.0	-1.0	-0.4	-0.8	2.0
Leg fat mass (right)	0.6	2.5	8.1	-1.6	-0.6	-0.4	-1.1	2.9
Arm predicted mass (right)	0.7	3.7	8.5	-2.3	1.7	1.4	-0.2	2.9
Pulse rate, automated reading	0.2	0.8	1.6	-1.1	-0.5	0.7	1.3	0.7
Alcohol intake frequency.	0.5	1.2	2.6	-0.8	-1.4	0.4	-0.8	1.6
Comparative height size at age 10	0.8	4.2	6.1	-2.5	0.6	1.9	2.3	2.4
Number of full sisters	0.2	0.3	0.5	0.2	-0.7	-0.7	-0.2	-0.5
Suffer from ‘nerves’	0.9	1.4	4.1	0.9	-0.5	1.0	2.0	-0.8
Overall health rating	0.8	1.7	6.1	-1.4	-0.5	-0.4	-0.5	2.5
Chest pain or discomfort	1.2	1.7	5.9	-1.1	2.4	0.4	0.9	0.6
Had major operations	0.6	0.7	1.9	-0.4	-1.4	-0.9	-0.4	0.4
Age at last live birth	1.8	2.6	4.8	-2.2	1.6	1.6	0.9	1.6
Family relationship satisfaction	1.0	1.3	2.1	1.0	-1.3	-1.2	-1.5	-0.3
Leg pain on walking	1.5	1.9	3.3	1.5	-0.8	-1.3	-1.3	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	0.5	-0.5	0.1	-1.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	0.6	1.1	0.5	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	0.3	-0.4	0.8	1.4	-0.6
Medication: Aspirin	2.9	3.9	8.7	-2.8	-0.5	1.4	0.8	3.0
Supplements: Vitamin C	0.4	0.5	1.5	0.5	-1.2	-0.2	-0.7	-0.2
Knee pain experienced in last month	1.5	2.3	7.4	-1.6	0.6	-0.0	-1.1	2.7
Hypertension (Self-reported)	1.8	5.1	14.7	-3.0	0.6	1.1	0.5	3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.7	0.3	-0.0	0.7	0.5	-0.8
Illnesses of father: Heart disease	0.8	1.1	2.3	-1.5	-0.4	0.5	0.8	1.5
Illnesses of siblings: Diabetes	1.1	1.3	3.1	0.8	0.7	-1.5	-1.8	0.3
Smoking status: Previous	2.2	3.3	7.3	1.6	-0.5	-2.7	-2.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.1	-0.0	-0.6	1.0	1.1	0.4
Whole body fat-free mass	0.5	2.8	7.6	-1.9	1.2	1.0	-0.5	2.8
Leg fat-free mass (right)	0.3	1.4	4.0	-1.2	0.2	0.1	-1.2	2.0
Arm fat percentage (left)	0.5	2.2	4.9	0.2	-2.2	-1.6	-1.5	1.0
Average weekly red wine intake	0.2	0.4	0.8	-0.3	0.9	0.1	0.9	-0.2
Handedness (chirality/laterality): Left-handed	1.9	2.2	3.7	-1.9	1.3	1.2	1.3	1.7
Mood swings	0.5	0.9	1.8	1.0	0.5	-0.9	-1.3	-0.6
Loneliness, isolation	1.2	1.7	3.1	-1.1	-1.2	1.2	1.8	1.1
Long-standing illness, disability or infirmity	0.5	0.8	2.6	0.1	-1.6	-1.0	-0.6	0.3
Ever had bowel cancer screening	1.5	1.8	3.4	-1.5	1.9	0.6	1.1	1.3
Diabetes diagnosed by doctor	1.4	2.3	7.2	-1.9	0.5	0.0	-0.6	2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	-0.8	0.7	-0.0	0.8	0.6
Friendships satisfaction	1.8	2.3	4.9	1.9	-2.2	-1.2	-0.5	-1.2
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.6	0.7	-0.3	0.1	0.4
Commuting to job workplace: Walk	1.5	1.6	3.0	1.4	-0.8	-1.7	-0.6	-1.5
Eye problems/disorders: Cataract	0.9	1.0	2.9	-0.4	0.7	1.3	1.7	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.9	1.2	-0.7	-1.8	-2.0	-0.4
Medication for cholesterol	1.3	1.9	5.7	1.5	0.2	-1.1	-0.6	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.3	-0.3	-1.1	0.9	0.2	0.7
Back pain experienced in last month	0.4	0.7	2.0	0.5	1.4	0.1	-1.0	-0.0
Mineral and other dietary supplements	2.4	3.2	8.0	-2.4	1.5	0.1	-0.2	2.8
Breast cancer (self-reported)	1.7	2.1	3.8	-1.8	0.6	1.9	0.9	1.5
Asthma (self-reported)	1.1	2.3	5.9	-1.7	2.4	0.7	1.0	1.1
Osteoporosis (self-reported)	4.9	6.0	9.6	3.1	-1.8	-2.6	-1.4	-2.9
Osteoarthritis (self-reported)	0.8	1.0	3.3	-0.6	0.5	-0.9	-1.8	0.5
Medication: Aspirin	2.3	3.0	7.8	-2.4	-0.3	1.1	0.3	2.8
Medication: Gliclazide	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0
Illnesses of father: None of the above (group 1)	0.9	1.1	3.0	1.3	0.2	-0.7	-0.5	-1.7
Smoking status: Current	3.2	5.2	12.7	-2.7	-0.9	1.7	1.3	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	10.2	-1.1	-3.2	1.1	1.2	1.4
Whole body water mass	0.4	2.6	7.1	-1.8	1.1	0.9	-0.5	2.7
Leg predicted mass (right)	0.3	1.4	4.2	-1.3	0.2	0.2	-1.1	2.0
Arm fat mass (left)	0.4	1.5	3.7	-0.7	-1.2	-0.8	-1.2	1.9
Number of self-reported non-cancer illnesses	1.9	3.3	5.4	-2.3	1.9	1.2	0.9	2.3
Average weekly champagne plus white wine intake	0.7	0.9	3.0	0.5	-0.1	0.6	1.7	-1.0
Miserableness	1.6	2.8	4.9	1.8	-0.1	-2.0	-2.2	-1.4
Guilty feelings	0.1	0.1	0.4	-0.0	0.6	0.2	0.1	-0.3
Wears glasses or contact lenses	0.2	0.3	0.6	-0.8	0.7	-0.2	-0.2	0.4
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.0	-1.2	0.5	1.2	0.5
Hearing aid user	7.0	7.9	10.8	-3.3	3.1	2.6	1.6	3.1
Mother’s age at death	0.6	0.8	1.7	0.5	0.6	-1.0	-1.3	-0.8
Financial situation satisfaction	0.1	0.1	0.5	-0.0	0.1	-0.7	0.1	-0.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.4	-1.4	-0.5	0.9	0.3	1.8
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.8	-0.5	-0.1	0.8	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.2	-1.1	-0.5	-0.9	0.8
Medication: Blood pressure	0.9	1.7	4.1	-1.6	0.5	0.9	0.8	2.0
Pain type(s) experienced in last month: Hip pain	1.6	2.1	5.0	1.1	0.5	-1.9	-2.2	-0.3
Supplements: Fish oil (including cod liver oil)	2.4	3.2	6.9	2.4	-1.6	-0.6	-0.3	-2.6
High cholesterol (Self-reported)	2.5	4.4	10.6	-2.5	0.2	2.0	1.2	3.2
Medication: Bendroflumethiazide	5.9	9.0	17.0	-3.9	1.5	2.6	2.0	4.1
Medication: Paracetamol	0.4	0.6	2.5	0.0	-1.6	-0.5	-0.6	0.0
Medication: Lisinopril	3.2	4.1	8.1	-2.6	0.3	2.3	0.5	2.8
Medication: Atorvastatin	1.4	1.8	3.1	-1.6	0.5	1.4	0.9	1.8
Illnesses of father: High blood pressure	2.1	2.6	4.5	-2.1	-1.7	0.7	0.9	2.1
Alcohol drinker status: Never	0.6	0.7	1.6	-0.8	-1.0	-0.4	-0.5	1.3
Ever smoked	0.8	1.5	3.4	0.6	-0.4	-1.8	-1.8	0.1
Basal metabolic rate	0.4	2.2	6.9	-1.7	0.8	0.7	-0.7	2.6
Leg fat percentage (left)	0.6	2.1	7.1	-1.3	-0.8	-0.6	-0.9	2.7
Arm fat-free mass (left)	0.8	4.0	11.0	-2.3	1.4	1.2	-0.3	3.3
Number of operations (self-reported)	0.9	1.4	3.1	0.7	-0.2	-1.8	-1.6	-0.8
Average weekly beer plus cider intake	0.7	1.0	3.2	-1.0	-1.8	0.1	0.0	0.8
Irritability	0.1	0.2	0.4	0.5	0.6	0.2	-0.5	-0.3
Risk taking	0.1	0.1	0.2	0.4	-0.1	-0.2	-0.5	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.1	0.8	-0.0	-0.3	0.4
Fractured/broken bones in last 5 years	6.4	8.3	12.0	2.7	-3.1	-3.3	-3.5	-1.4
Age started oral contraceptive pill	0.6	0.8	2.8	0.1	1.7	-0.8	0.4	-0.7
Diastolic blood pressure, automated reading	0.4	1.1	2.1	-1.4	0.7	0.7	0.7	1.5
Ever depressed for a whole week	0.2	0.2	0.6	0.1	-0.1	-0.8	0.3	-0.5
Unable to work because of sickness or disability	3.9	5.0	14.6	-2.9	-1.2	0.5	0.5	3.8
Commuting to job workplace: Cycle	2.6	3.1	5.4	-1.7	0.7	2.3	2.2	1.4
Myopia	0.4	0.6	1.3	0.4	-0.9	-1.2	0.2	-0.8
Vascular/heart problems diagnosed by doctor	2.2	6.0	17.5	3.3	-0.4	-1.1	0.0	-4.2
Cholesterol lowering medication	1.2	1.8	6.2	-1.3	0.8	0.6	0.4	2.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.8	0.7	-0.9	0.2	1.7	-0.5
Pain experienced in last month	0.3	0.5	1.2	-0.0	-1.1	-0.4	0.4	-0.9
Supplements: Calcium	1.3	1.5	2.9	1.6	-1.7	-0.8	-0.7	-1.0
Basal cell carcinoma (self-reported)	0.5	0.6	2.1	-0.3	1.4	0.4	0.5	-0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.4	5.3	-2.2	0.7	1.0	0.4	2.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.0	1.0	-0.5	-0.7	-0.3
Heart disease (siblings)	1.0	1.2	4.7	-0.4	2.2	1.0	0.3	0.2
Alcohol drinker status: Previous	0.3	0.4	1.1	-0.5	-0.4	-0.1	-0.6	1.1
Pack years of smoking	2.8	4.1	6.6	-2.2	0.9	2.6	2.0	2.1
Impedance of whole body	0.7	3.6	12.3	1.8	0.3	-0.3	1.6	-3.5
Leg fat mass (left)	0.7	2.5	8.6	-1.6	-0.6	-0.3	-1.0	2.9
Arm predicted mass (left)	0.7	3.8	10.8	-2.2	1.4	1.0	-0.6	3.3