TWAS hub - SOX6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.323	0.0794	4.0e-05	0.172	NA	0.133	NA	0.164	9.2e-07	NA	1.7e-05	NA	1.6e-06
2	GTEx	Liver	0.514	0.0870	5.6e-06	0.389	NA	0.360	NA	0.329	6.9e-12	NA	6.1e-11	NA	5.9e-10
3	GTEx	Skin Sun Exposed Lower leg	0.080	0.0340	5.6e-03	0.003	NA	-0.002	NA	0.000	1.8e-01	NA	4.8e-01	NA	3.1e-01
4	TCGA	Liver Hepatocellular Carcinoma	0.212	0.1020	7.7e-03	0.054	0.023	0.077	NA	0.094	1.4e-03	0.029	1.8e-04	NA	3.5e-05
5	TCGA	Pancreatic Adenocarcinoma	0.121	0.0580	7.3e-03	-0.005	0.025	0.005	NA	0.012	6.0e-01	0.031	1.8e-01	NA	9.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Blood pressure	7.6	13.5	19.4	-0.4	-4.2	-3.6	-4.4	-4.1
Systolic Blood Pressure	6.6	33.3	54.6	-1.6	-5.8	-6.4	-5.9	-7.4
High blood pressure	6.2	17.2	33.1	-0.9	-4.0	-4.1	-4.3	-5.8
Vascular/heart problems diagnosed by doctor	5.8	15.7	33.7	1.2	3.5	4.1	3.8	5.8
Hypertension (Self-reported)	5.4	14.9	31.1	-1.0	-3.6	-4.0	-3.7	-5.6
Medication for cholesterol, blood pressure or diabetes	4.6	7.5	15.8	0.7	2.3	3.4	2.2	4.0
Loneliness, isolation	4.4	6.1	13.2	1.2	3.6	-0.0	3.1	2.5
Heel T-Score	4.3	34.0	71.1	-4.4	-6.8	4.0	-4.1	-8.4
Medication: Lisinopril	4.1	5.3	10.2	-1.1	-2.6	-2.3	-1.8	-3.2
Medication: Ramipril	4.0	5.1	10.6	-0.5	-2.2	-3.3	-1.9	-2.5
Relative age of first facial hair	3.8	7.7	20.3	3.1	0.1	4.5	-0.1	3.0
Cardiovascular Disease	3.7	12.4	22.5	-1.0	-3.0	-4.0	-3.7	-4.7
Medication: Atenolol	3.7	4.6	7.3	-2.0	-2.7	-1.3	-2.4	-2.1
Handedness (chirality/laterality): Left-handed	3.5	4.2	9.3	-1.8	-0.6	-2.9	0.2	-3.1
Fractured/broken bones in last 5 years	3.5	4.6	7.8	2.2	2.8	-0.5	2.2	2.3
Hearing difficulty/problems with background noise	3.3	5.3	10.3	-2.4	1.7	-2.6	0.8	-3.2
Depressed Affect (Nagel 2018)	3.2	6.7	15.7	1.8	2.1	3.1	1.0	4.0
Systolic blood pressure, automated reading	3.2	9.3	18.5	0.3	-3.1	-2.8	-3.3	-4.3
Diastolic blood pressure, automated reading	3.2	9.9	14.1	-1.9	-3.7	-3.2	-2.7	-3.8
Major Depression (MDD)	3.1	3.8	12.3	2.3	0.6	3.5	-0.4	1.1
Hearing difficulty/problems: Yes	3.0	4.6	9.6	-3.1	1.7	-1.7	1.6	-2.2
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	9.9	2.0	3.1	0.9	1.8	2.4
Osteoporosis (self-reported)	3.0	3.8	10.0	0.4	3.2	-1.3	1.9	1.8
Hearing aid user	2.7	3.1	9.8	-1.9	0.4	0.5	1.2	-3.1
Medication: Ventolin 100micrograms inhaler	2.6	3.3	6.8	-2.6	0.9	-1.6	2.0	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	12.3	-1.1	-3.0	2.0	-1.5	-3.5
Ever had hysterectomy (womb removed)	2.4	2.7	6.2	1.2	-2.2	-0.7	-2.5	-0.7
Eye problems/disorders: Cataract	2.4	2.8	11.1	-0.0	0.5	3.3	-1.1	1.2
Crohns Disease (2017)	2.3	5.0	9.9	3.1	2.2	1.8	1.4	2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	6.6	-2.6	1.9	0.7	1.1	-0.5
Schizophrenia (2018)	2.2	4.6	10.3	3.2	-1.2	1.5	-0.9	2.9
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.1	8.6	-0.9	-2.7	2.8	-0.9	-2.9
Depression (self-reported)	2.2	2.7	6.4	2.5	1.2	1.4	0.8	1.7
Emphysema/chronic bronchitis	2.2	2.5	3.8	1.2	1.7	1.2	1.8	2.0
Supplements: Fish oil (including cod liver oil)	2.2	2.9	5.8	-0.4	1.4	1.9	2.4	1.7
Illnesses of father: High blood pressure	2.2	2.8	8.1	-1.1	-0.7	-1.9	-0.5	-2.8
Depression (Nagel 2018)	2.1	3.2	5.5	1.4	1.9	2.3	-0.2	2.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.0	1.4	-1.3	2.2	-1.8	0.2
Impedance of leg (right)	2.1	9.9	36.2	-6.0	0.9	-2.9	1.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	5.9	1.6	2.4	1.1	0.8	2.0
Alcohol intake versus 10 years previously	2.1	3.1	7.7	2.8	0.2	1.5	0.7	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.3	12.8	-0.3	3.6	0.6	2.9	0.1
Prostate Cancer	2.0	2.8	4.6	2.1	-2.1	0.4	-2.1	0.8
Severe depression (siblings)	2.0	2.2	6.6	2.6	-0.9	0.1	-1.7	0.8
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.4	-0.9	-2.3	-0.6	-1.8	-1.2
Average weekly champagne plus white wine intake	2.0	2.7	7.4	1.6	1.4	1.1	0.6	2.7
Alcohol drinker status: Never	2.0	2.4	4.7	0.2	-1.7	-0.5	-2.0	-2.2
Ever depressed for a whole week	2.0	2.5	5.8	1.2	0.7	2.4	-0.1	2.1
Bipolar Disorder or Schizophrenia	1.9	4.6	8.9	3.0	-1.9	1.9	-1.4	2.1
Bipolar Disorder (2011)	1.9	1.8	4.3	0.6	-1.0	2.1	-1.8	-0.0
Crohns Disease (2012)	1.9	3.1	7.0	2.7	1.0	1.5	0.6	2.2
High blood pressure (mother)	1.9	2.7	7.0	1.7	-1.4	-0.6	-2.6	-1.1
Birth weight of first child	1.9	3.5	6.7	1.9	0.4	2.5	-0.9	2.6
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	5.5	-1.0	1.8	-2.3	1.6	0.4
Medication: Bendroflumethiazide	1.9	2.9	9.3	-1.0	-0.9	-0.3	-1.8	-3.0
Lung FVC	1.8	9.0	21.9	-2.6	4.0	0.7	4.7	0.2
Maternal smoking around birth	1.8	2.6	4.4	2.1	0.3	-0.1	-2.0	2.1
Glaucoma (self-reported)	1.8	2.2	6.7	-1.0	0.1	-2.6	0.1	-1.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.0	0.3	1.6	-1.6	2.0	0.1
Average weekly fortified wine intake	1.7	2.0	5.8	2.4	1.7	0.6	-0.2	0.9
Medication: Omeprazole	1.7	2.0	8.4	0.5	-0.5	-0.5	-0.9	2.9
Medication: Blood pressure	1.7	3.2	8.2	-1.6	-1.2	-1.5	-1.3	-2.9
Impedance of leg (left)	1.6	7.6	27.5	-5.2	1.1	-2.5	1.0	-1.3
Wheeze or whistling in the chest in last year	1.6	2.8	4.3	-1.7	1.9	-1.6	2.1	-0.3
Pulse wave peak to peak time	1.6	1.8	4.4	0.5	-1.7	0.4	-2.1	1.3
Illnesses of father: Heart disease	1.6	2.2	6.5	-1.0	-0.5	-1.7	-0.4	-2.5
Qualifications: nursing, teaching	1.6	2.5	4.7	1.8	-0.8	1.8	-2.2	1.0
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	4.5	-1.6	1.2	-1.7	1.4	-2.1
Supplements: Calcium	1.6	1.8	3.2	0.5	1.6	0.5	1.8	1.7
Reaction Time	1.5	2.9	6.7	2.0	-2.0	0.3	-2.6	0.3
Ovarian Cancer	1.5	2.0	3.6	-1.8	1.1	-1.9	0.2	-1.4
Schizophrenia (2014)	1.5	3.3	6.9	2.3	-1.2	1.6	-0.7	2.6
Respiratory disease	1.5	3.3	4.9	-1.9	1.8	-0.4	2.2	-2.1
Pulse wave Arterial Stiffness index	1.5	1.8	3.8	-0.7	1.5	-0.5	2.0	-1.5
Exposure to tobacco smoke at home	1.5	1.7	6.1	-0.6	1.2	-0.1	0.6	-2.5
Exposure to tobacco smoke outside home	1.5	2.1	7.0	1.2	0.7	0.8	0.8	2.6
Age at last live birth	1.5	2.1	5.7	-1.5	-0.7	-1.1	-1.0	-2.4
Mineral and other dietary supplements	1.5	2.1	4.8	-0.5	-0.5	-0.8	-2.1	-2.2
Breast cancer (self-reported)	1.5	1.8	7.1	-0.9	-0.5	-0.8	0.1	-2.7
LDL Cholesterol	1.4	2.3	6.4	-1.7	1.4	0.4	2.5	-0.0
Medication for hormone replacement therapy	1.4	1.6	5.0	0.6	-2.2	1.2	-0.6	0.8
Medication: Co-codamol	1.4	1.7	3.6	-1.9	1.5	-0.4	0.9	-1.2
Qualifications: CSEs or equivalent	1.4	1.9	3.7	-0.6	-1.9	-1.3	-1.1	-1.6
Hair/balding pattern: Pattern 2	1.4	1.7	3.4	-1.8	-1.4	-1.8	-0.5	0.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	3.8	-1.1	-2.0	-0.9	-1.8	-1.5
Medication: Aspirin	1.4	1.8	4.5	-0.6	-1.1	-1.1	-2.1	-1.4
Miserableness	1.4	2.4	3.9	1.0	1.8	1.8	0.8	2.0
Pack years adult smoking proportion	1.3	2.0	4.1	0.7	-0.9	1.2	-2.0	1.7
Hand grip strength (right)	1.3	3.4	5.8	2.4	-1.7	2.4	-1.5	0.8
Diabetes (self-reported)	1.3	2.0	3.6	0.2	-1.4	-1.4	-1.9	-1.6
Long-standing illness, disability or infirmity	1.3	2.0	5.5	1.1	-1.6	0.1	-2.4	0.8
Commuting to job workplace: Walk	1.3	1.4	3.2	0.3	1.2	-1.3	1.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.3	0.5	1.8	0.9	1.8	-0.0
Irritability	1.3	2.3	5.0	1.3	0.8	2.2	-1.2	1.6
Neuroticism (Nagel 2018)	1.2	2.8	8.6	1.0	0.8	1.8	-0.5	2.9
HbA1C	1.2	1.3	3.8	-1.4	0.5	2.0	0.6	0.2
Neuroticism	1.2	2.9	9.0	1.5	1.5	0.9	0.6	3.0
Vitamin and mineral supplements	1.2	1.7	3.3	-0.7	-1.0	-1.3	-1.8	-1.4
Chronic bronchitis/emphysema (father)	1.2	1.4	2.6	1.6	-1.0	1.5	-0.7	0.7
Financial difficulties in last 2 years	1.2	1.6	4.6	1.3	2.2	0.1	1.2	0.3
Pain all over the body in last month	1.2	1.3	5.4	0.4	-0.8	-0.4	0.4	2.3
Number of live births	1.2	1.7	3.7	-1.9	1.6	0.2	1.4	0.2
Mouth/teeth dental problems: Dentures	1.2	2.0	4.6	2.1	0.9	2.0	0.7	0.0
Pulse wave reflection index	1.2	1.5	4.5	0.4	1.5	0.8	2.1	-0.3
Loud music exposure frequency	1.2	1.3	3.0	-0.8	-0.4	-0.8	-1.7	-1.5
Forced vital capacity (FVC), Best measure	1.2	4.4	8.4	-2.9	2.1	-0.9	2.7	-0.9
Mean time to correctly identify matches	1.2	2.2	4.6	1.7	-1.6	0.6	-2.2	0.5
Mood swings	1.2	2.1	4.1	1.5	0.8	1.8	-0.7	2.0
Asthma (self-reported)	1.2	2.5	6.2	-2.1	-0.2	-0.5	1.2	-2.5
Unable to work because of sickness or disability	1.2	1.5	5.5	2.3	1.0	0.7	-0.2	-0.8
Tanning	1.1	14.0	43.8	6.6	3.9	0.1	2.6	2.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	6.8	0.4	2.6	0.2	0.7	0.7
Diabetes (father)	1.1	1.3	3.7	-0.5	-1.1	-1.9	-0.4	-1.1
Serious illness, injury or assault to yourself	1.1	1.3	1.7	1.3	1.3	0.3	1.2	1.3
Number of incorrect matches in round	1.1	1.9	5.3	-2.3	1.1	-0.5	1.2	-1.1
Qualifications: None of the above	1.1	2.4	5.2	0.0	2.3	1.5	2.1	0.4
Mouth/teeth dental problems	1.1	1.6	4.6	-0.8	-2.1	0.6	-1.5	0.4
Medication: Simvastatin	1.1	1.6	3.6	-1.2	-0.5	-1.6	-0.4	-1.9
Asthma	1.1	2.2	5.6	-2.0	-0.2	-0.5	1.1	-2.4
Lung cancer (father)	1.1	1.3	4.2	2.0	0.2	0.6	-1.1	0.7
Health satisfaction	1.1	1.4	2.8	-0.5	1.5	0.1	1.3	1.7
Medication: Seretide 50 evohaler	1.1	1.3	3.1	-1.0	0.9	0.0	1.8	-1.2
Impedance of whole body	1.1	5.8	20.9	-4.6	0.5	-2.5	1.2	-0.6
Alzheimer’s Disease (including proxy)	1.0	1.5	4.9	-0.1	2.2	-0.1	0.3	1.6
Blood Eosinophil Count	1.0	7.9	19.3	-4.4	1.8	-2.4	2.8	-1.8
Hand grip strength (left)	1.0	2.6	3.5	1.6	-1.9	1.8	-1.9	0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.6	-0.1	0.5	1.5	1.0	1.6
Fed-up feelings	1.0	1.9	4.4	1.0	2.1	0.5	0.2	1.9
Multivitamins +/- minerals	1.0	1.3	1.8	1.2	0.6	1.4	1.3	1.1
Supplements: Glucosamine	1.0	1.3	5.3	0.0	1.0	0.1	2.3	0.4
Heart attack	1.0	1.3	2.8	0.2	-1.3	-1.0	-1.1	-1.7
Medication: Cholesterol lowering	1.0	1.6	4.6	-0.8	-0.7	-1.1	-1.1	-2.1
Gout (self-reported)	1.0	1.4	3.8	1.9	0.4	1.2	-0.1	1.3
Shortness of breath walking on level ground	1.0	1.2	3.8	-0.3	1.9	-0.3	1.4	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.5	-0.6	1.6	-1.6	0.8	-0.1
Neck or shoulder pain in last month	1.0	1.5	5.2	-0.8	2.3	-0.9	0.5	-0.6
Medication: Ibuprofen	1.0	1.3	2.6	1.0	1.0	0.6	1.1	1.6
Alcohol intake frequency.	1.0	2.4	4.8	1.0	-1.8	0.8	-2.2	-1.5
Diabetes diagnosed by doctor	1.0	1.6	3.3	-0.2	-1.3	-0.8	-1.8	-1.5
Medication: Aspirin	1.0	1.3	3.1	-0.3	-0.9	-1.1	-1.8	-1.2
Pain experienced in last month	1.0	1.6	4.7	2.2	-1.6	-0.2	0.0	0.8
Heart attack/myocardial infarction (self-reported)	1.0	1.4	2.6	0.1	-1.3	-1.2	-1.0	-1.6
Pack years of smoking	1.0	1.5	2.8	0.3	-0.7	1.1	-1.7	1.6
Worry (Nagel 2018)	0.9	1.8	3.9	0.3	-1.1	-0.9	-2.0	1.7
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.1	-0.7	-0.6	-1.1	-2.0	-1.4
Impedance of arm (right)	0.9	4.1	12.0	-3.5	-0.2	-2.8	0.7	-0.5
Time employed in main current job	0.9	1.1	1.6	-0.7	-1.2	-1.1	-1.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.1	1.3	1.7	0.1	-0.2	1.8
Length of working week for main job	0.9	1.0	1.9	-0.9	-0.7	-1.4	0.1	-1.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.0	0.2	-0.2	-1.3	0.6	1.7
High blood pressure (siblings)	0.9	1.3	3.3	0.2	-0.4	-1.8	0.3	-1.8
Age at first live birth	0.9	1.7	4.7	-1.0	-1.2	0.3	-2.2	-1.1
Knee pain experienced in last month	0.9	1.4	4.1	-0.5	2.0	-0.1	0.4	-1.6
Smoking status: Previous	0.9	1.4	3.1	0.4	0.0	-1.4	1.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.0	0.2	-1.9	-1.0	-2.0	-0.1
Number of self-reported non-cancer illnesses	0.9	1.5	2.0	-1.1	-1.4	-0.8	-1.4	-1.2
Ever taken oral contraceptive pill	0.9	1.0	3.8	-0.1	0.7	0.1	0.9	1.9
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.5	-0.3	1.6	0.5	1.6	-0.3
Bipolar Disorder (2018)	0.8	1.3	2.6	0.8	-1.6	1.3	-1.1	-0.3
Average weekly spirits intake	0.8	0.9	3.6	0.5	0.9	1.9	0.3	0.2
Sensitivity / hurt feelings	0.8	1.3	5.2	-2.3	0.3	-0.9	0.2	-0.8
Stomach or abdominal pain in last month	0.8	1.0	3.0	0.8	-0.6	0.6	-1.7	0.9
Alcohol usually taken with meals	0.8	1.3	1.7	1.3	1.1	0.4	1.3	1.3
Had menopause	0.8	1.0	4.5	0.1	0.3	0.3	0.4	2.1
Headache pain in last month	0.8	1.4	5.5	-0.9	2.4	-0.0	0.7	-0.3
Eye problems/disorders: None of the above	0.8	0.9	2.5	0.2	0.7	-1.3	1.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.2	0.8	-1.1	1.0	-1.1	0.9
Overall health rating	0.8	1.7	3.3	1.4	1.8	0.7	0.2	1.7
Family relationship satisfaction	0.8	0.9	2.3	1.3	0.5	0.5	0.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	1.1	-0.2	1.0	-1.2	1.1
Ever had bowel cancer screening	0.8	1.0	4.5	0.5	0.3	2.1	0.1	0.3
Medication for cholesterol	0.8	1.1	2.3	0.6	1.4	0.6	0.7	1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.7	-0.2	0.2	-0.9	-0.4	1.9
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	0.2	0.9	-0.5	1.3	1.3
Alzheimer’s Disease (in mother)	0.7	0.8	2.2	-1.2	1.5	-0.4	0.3	0.3
Blood Red Count	0.7	6.4	20.6	-2.2	-0.1	-4.5	-0.7	-2.5
Smoking Status	0.7	1.7	6.7	2.6	0.4	0.9	0.7	0.6
Chronotype (morning person)	0.7	1.6	4.0	-1.9	-2.0	0.0	-0.7	-0.2
Townsend deprivation index at recruitment	0.7	1.0	3.1	1.8	0.9	-1.1	-0.1	0.4
Age when periods started (menarche)	0.7	1.6	4.8	-2.2	-1.7	0.4	-0.2	-0.0
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.3	-0.6	2.1	-1.0	1.2	-1.0
Medication: Levothyroxine sodium	0.7	1.2	2.7	0.6	0.8	0.7	1.6	1.4
Nervous feelings	0.7	1.4	4.2	0.8	-0.7	-0.6	-2.0	1.1
Forced vital capacity (FVC)	0.7	2.8	5.9	-2.4	1.6	-0.1	2.4	-0.0
Allergy	0.7	1.7	2.4	1.5	-1.5	1.0	-0.8	1.5
Happiness	0.7	0.8	2.8	0.1	0.9	-0.7	0.3	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	1.4	0.2	0.2	-0.0	1.5
Prospective memory result	0.7	0.9	1.8	-1.1	1.0	0.3	1.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.4	-1.4	2.1	-1.0	2.0	-0.6
Hair/balding pattern: Pattern 4	0.7	1.7	4.2	-2.0	-0.4	0.9	-0.3	-1.7
Medication: Amlodipine	0.7	0.9	1.9	0.3	-1.4	-1.0	-0.9	-1.0
Leg fat percentage (right)	0.7	2.4	5.7	-1.2	1.7	-1.4	0.2	-2.4
Heart disease (mother)	0.7	0.9	2.2	1.2	-0.6	0.6	-1.5	0.4
Suffer from ‘nerves’	0.7	1.1	3.8	0.6	-0.8	-0.4	-0.8	2.0
Supplements: Vitamin C	0.7	0.9	2.0	-0.9	1.1	-0.4	1.4	-0.4
Illnesses of siblings: Diabetes	0.7	0.9	1.8	0.0	1.3	-0.6	0.7	-1.3
Average weekly red wine intake	0.7	1.0	3.6	0.3	1.9	-0.2	1.2	-0.2
Age started oral contraceptive pill	0.7	0.9	3.5	-1.9	-0.3	-0.4	-0.6	0.7
Irritable Bowel Disease (IBD)	0.6	1.4	3.0	1.7	0.7	1.2	0.6	1.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	-1.1	-0.7	0.1	-0.6	-1.4
Waist Hip Ratio (WHR)	0.6	2.7	5.3	-2.2	1.8	-0.2	2.3	-0.4
Supplements: Zinc	0.6	0.7	2.8	0.5	0.1	-0.0	1.7	0.6
Relative age voice broke	0.6	0.9	1.5	1.2	0.7	1.2	0.4	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	-0.5	1.1	0.9	0.4	1.1
Neuroticism score	0.6	1.2	4.0	0.8	1.2	0.0	0.1	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	1.5	-0.2	0.9	-0.5	0.1
Impedance of arm (left)	0.6	2.7	9.1	-3.0	-0.3	-2.0	0.4	0.0
Blood clot in the leg (DVT)	0.6	0.8	3.1	-1.8	0.2	0.0	-0.1	-1.0
Number of children fathered	0.6	0.7	1.1	-1.0	0.5	1.0	1.0	0.1
Medication: Allopurinol	0.6	0.8	2.2	0.5	0.5	1.0	0.5	1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	-1.2	-0.8	0.7	-0.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.0	0.4	-0.4	-0.0	-1.7	0.5
Friendships satisfaction	0.6	0.8	2.3	0.1	0.9	0.8	0.3	1.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	0.1	0.4	1.1	0.9	1.3
Guilty feelings	0.6	0.9	1.8	1.4	0.8	0.1	0.8	1.1
High cholesterol (Self-reported)	0.6	1.0	2.6	-1.6	-0.3	-1.2	0.1	-1.0
Ever smoked	0.6	1.1	2.5	1.6	1.1	0.7	0.9	-0.5
Commuting to job workplace: Cycle	0.6	0.7	1.3	0.9	-0.6	1.0	-1.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.3	-1.5	0.1	0.1	0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.3	2.5	0.2	0.7	0.8	0.6
Alzheimer’s Disease (in father)	0.5	0.6	2.3	-0.3	1.5	0.2	-0.0	0.7
Breast Cancer	0.5	1.1	3.3	-0.9	0.5	-1.8	-0.9	0.6
HDL Cholesterol	0.5	0.9	2.4	-0.3	1.2	0.5	1.6	-0.4
Primary Biliary Cirrhosis	0.5	0.7	1.1	0.9	0.9	1.0	0.9	0.4
Ulcerative Colitis	0.5	0.7	3.0	0.3	-0.4	1.7	0.2	0.5
Allergy or Eczema	0.5	1.4	2.5	-1.1	1.6	-0.5	1.2	-1.4
Father’s age at death	0.5	0.7	1.2	-0.5	-1.1	1.1	-0.5	0.9
Falls in the last year	0.5	0.7	2.1	0.5	0.4	-1.5	-1.0	-0.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.1	1.2	-0.2	0.7	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.9	-1.5	1.3	-0.8	1.7	0.1
Pulse rate	0.5	0.8	2.4	-0.1	1.1	0.5	1.5	0.2
Noisy workplace	0.5	0.6	1.5	1.2	-0.1	-0.9	-0.8	0.0
Illnesses of mother	0.5	0.6	1.9	-1.1	-0.1	-0.0	1.4	0.0
Breastfed as a baby	0.5	0.6	1.7	0.2	-0.5	0.6	-0.8	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.8	-0.1	1.3	-0.9	0.8
Number of full brothers	0.5	0.7	1.3	1.1	0.7	-0.5	1.0	0.4
Angina (self-reported)	0.5	0.6	1.5	-1.2	0.6	-0.2	-0.6	-0.9
Pulse rate, automated reading	0.5	1.6	3.3	-1.8	0.3	-0.0	1.7	-1.2
Comparative height size at age 10	0.5	2.6	5.9	-2.4	1.2	-1.9	1.4	-0.4
Had major operations	0.5	0.6	1.4	-0.7	0.9	-1.2	0.5	0.0
Medication: Gliclazide	0.5	0.6	2.3	-1.5	-0.1	-0.6	-0.3	0.2
Wears glasses or contact lenses	0.5	0.5	1.3	0.6	0.1	1.1	-0.4	-0.9
Financial situation satisfaction	0.5	0.6	1.4	-0.5	-0.3	-1.2	-1.1	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.6	-0.1	-1.3	-0.8	-0.9	-0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.5	0.4	0.6	0.1	-1.6	0.3
Leg fat percentage (left)	0.5	1.7	3.6	-0.5	1.9	-1.0	0.2	-1.9
Number of operations (self-reported)	0.5	0.7	1.5	1.2	0.5	0.8	-0.7	0.8
Average weekly beer plus cider intake	0.5	0.7	1.0	0.9	1.0	-0.9	0.8	-0.2
Heart disease (siblings)	0.5	0.6	2.3	-1.5	-0.0	0.4	-0.0	-0.7
Coronary Artery Disease (CAD)	0.4	0.5	2.2	-1.5	-0.1	0.6	0.0	0.1
Triglycerides	0.4	0.7	2.4	-1.6	-0.3	-0.5	-0.7	0.3
Blood Platelet Count	0.4	4.9	12.7	3.1	-0.5	-3.6	-0.7	-1.0
BMI	0.4	2.0	5.7	2.4	0.6	1.7	-1.0	0.2
Height	0.4	7.0	29.7	-5.5	-1.0	0.4	1.5	-1.3
Lung FEV1/FVC ratio	0.4	1.9	7.9	2.8	0.7	-0.3	-0.1	0.9
Hair Pigment	0.4	10.9	24.7	-4.5	1.7	2.6	0.8	5.0
Number of treatments/medications taken	0.4	0.6	1.2	-0.4	-1.0	-0.9	-0.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	1.3	0.1	0.3	0.1	0.8
Angina	0.4	0.5	1.1	-1.0	0.8	-0.0	-0.5	-0.8
Current tobacco smoking	0.4	0.7	1.6	1.2	-0.3	1.3	-0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	1.0	0.3	0.5	-0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.1	0.5	0.0	-0.0	-0.4	1.4
Sitting height	0.4	3.1	6.6	-2.1	-2.6	1.8	-1.1	0.1
Past tobacco smoking	0.4	0.7	3.1	-1.8	-0.0	0.1	-0.4	0.6
Worrier / anxious feelings	0.4	0.7	1.9	0.5	0.7	-1.4	-0.5	0.7
Tense / ‘highly strung’	0.4	0.7	1.2	-1.1	-0.7	-0.6	-1.1	0.5
Peak expiratory flow (PEF)	0.4	0.9	3.3	1.8	1.0	0.1	0.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	0.1	0.9	-0.9	0.9	0.3
Chest pain or discomfort	0.4	0.6	1.9	0.8	0.3	-0.7	-0.1	1.4
Leg pain on walking	0.4	0.5	1.0	-0.9	-0.5	1.0	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	0.1	-0.3	0.7	-0.5	1.3
Leg fat-free mass (right)	0.4	2.0	6.8	2.6	-0.9	1.1	-1.1	0.3
Smoking status: Current	0.4	0.7	1.9	1.1	0.2	1.4	-0.3	0.3
Leg predicted mass (right)	0.4	1.9	6.5	2.5	-0.9	1.1	-1.0	0.3
Mother’s age at death	0.4	0.5	0.9	-0.1	0.9	1.0	0.9	0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.6	0.1	-0.8	-0.1	-1.2
Medication: Atorvastatin	0.4	0.5	1.1	-0.6	-0.4	-0.3	-1.1	-0.9
Risk taking	0.4	0.5	1.1	-0.4	0.9	1.0	0.7	0.4
Myopia	0.4	0.5	2.2	-0.6	-0.2	-1.5	0.1	0.4
Mean Putamen Volume	0.3	0.3	1.2	0.1	-0.3	0.4	-1.1	0.1
Fasting Glucose	0.3	0.3	0.7	-0.9	-0.1	-0.0	-0.8	-0.5
Lupus	0.3	0.4	1.4	-0.1	0.4	1.2	-0.5	0.4
Neuroticism (2016)	0.3	0.5	1.6	0.2	0.7	0.2	0.5	1.3
Medication: Metformin	0.3	0.5	1.1	-0.2	-0.6	-1.0	-0.7	-0.7
Leg fat-free mass (left)	0.3	1.5	4.9	2.2	-1.0	0.9	-1.0	0.1
Leg predicted mass (left)	0.3	1.5	4.9	2.2	-1.0	0.9	-1.0	0.0
Fluid intelligence score	0.3	0.7	1.5	0.9	0.5	-0.9	1.2	-0.4
Illnesses of siblings	0.3	0.5	1.1	-0.4	-0.3	0.7	-0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.2	-1.1	-0.2	-1.1	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.9	0.1	0.3	0.1	0.9
Body fat percentage	0.3	1.0	2.0	-0.7	1.3	-1.0	0.3	-1.4
Comparative body size at age 10	0.3	0.8	1.8	1.3	-0.4	0.4	-1.4	0.5
Migraine (self-reported)	0.3	0.4	0.6	0.2	-0.7	0.6	0.8	-0.5
Leg fat mass (right)	0.3	1.2	4.2	-0.5	0.6	-0.9	-0.4	-2.0
Back pain experienced in last month	0.3	0.4	0.9	-0.9	0.0	0.1	-0.8	-0.5
Osteoarthritis (self-reported)	0.3	0.4	1.2	0.7	-0.6	0.1	-1.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	0.9	0.5	0.4	1.1	0.4
Rheumatoid Arthritis	0.2	0.3	1.0	0.4	0.1	1.0	-0.3	0.2
Blood White Count	0.2	1.8	3.3	-0.9	1.6	-1.2	1.0	-1.8
Hypothyroidism (self reported)	0.2	0.6	2.0	-0.1	0.4	-0.7	1.4	-0.4
Diabetes (mother)	0.2	0.2	0.7	0.1	0.4	0.4	-0.0	-0.9
Trunk fat percentage	0.2	0.8	1.5	-0.7	0.9	-1.2	0.3	-1.0
Taking other prescription medications	0.2	0.3	0.8	-0.4	-0.5	0.2	-0.9	-0.5
Body mass index (BMI)	0.2	0.9	3.1	1.8	0.6	0.2	-0.5	-0.8
Had other major operations	0.2	0.2	0.5	0.4	0.5	0.2	-0.7	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.5	0.5	-0.2	0.6	-0.8
Arm fat percentage (right)	0.2	0.7	1.6	0.3	0.8	-1.3	-0.0	-1.1
Medication: Lansoprazole	0.2	0.2	0.5	0.1	0.5	0.7	-0.4	0.0
Standing height	0.2	2.4	10.2	-3.2	-1.3	0.1	0.1	-0.3
Medication: Paracetamol	0.2	0.4	0.6	-0.8	-0.5	-0.8	-0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.1	-0.1	-0.1	-0.6	1.0	0.4
Birth weight	0.2	0.4	1.0	0.5	-0.3	0.5	0.7	1.0
Arm fat-free mass (right)	0.2	0.9	2.2	1.5	-0.4	1.5	-0.4	0.0
Worry too long after embarrassment	0.2	0.3	0.4	0.5	0.6	-0.1	-0.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.0	-0.9	0.5	-0.5	0.1
Qualifications: College or University degree	0.2	0.7	1.9	0.8	-1.4	0.4	-1.0	0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.2	-0.5	0.2	0.4	-1.0
Arm predicted mass (right)	0.2	0.8	2.0	1.3	-0.5	1.4	-0.4	0.1
Number of full sisters	0.2	0.2	0.4	0.3	0.5	-0.0	0.6	-0.6
Whole body fat-free mass	0.2	1.2	2.9	1.7	-0.7	1.4	-0.7	0.3
Whole body water mass	0.2	1.2	3.0	1.7	-0.8	1.3	-0.8	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.4	-0.4	0.5	0.6	0.0
Alcohol drinker status: Previous	0.2	0.2	0.7	0.9	-0.3	0.0	-0.3	0.1
Leg fat mass (left)	0.2	0.8	3.0	-0.1	0.7	-0.6	-0.5	-1.7
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.2	-0.8	-0.0	-0.6	-0.2
Age at First Birth	0.1	0.1	0.3	-0.1	-0.4	0.1	-0.5	0.0
Trunk fat mass	0.1	0.5	1.3	-0.5	0.6	-0.8	0.0	-1.1
Waist circumference	0.1	0.3	0.8	0.6	0.9	0.1	-0.2	-0.1
Trunk fat-free mass	0.1	0.8	2.1	1.1	-0.6	1.4	-0.5	0.2
Hip circumference	0.1	0.6	1.2	0.9	-0.0	0.2	-1.0	1.1
Arm fat mass (right)	0.1	0.4	1.0	0.5	0.4	-0.5	-0.3	-1.0
Trunk predicted mass	0.1	0.8	2.1	1.1	-0.7	1.4	-0.6	0.2
Whole body fat mass	0.1	0.6	1.7	-0.5	0.8	-0.5	0.1	-1.3
Arm fat percentage (left)	0.1	0.5	0.9	0.6	0.6	-1.0	-0.3	-0.9
Arm fat mass (left)	0.1	0.3	0.6	0.5	0.4	-0.6	-0.3	-0.8
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.2	-0.5	-0.3	0.3	0.0
Basal metabolic rate	0.1	0.7	2.0	1.4	-0.5	0.9	-0.6	0.0
Arm fat-free mass (left)	0.1	0.6	1.7	1.2	-0.0	1.3	-0.2	-0.1
Cholesterol lowering medication	0.1	0.1	0.2	-0.2	-0.5	0.3	-0.1	-0.1
Arm predicted mass (left)	0.1	0.5	1.2	1.1	-0.1	1.1	-0.3	-0.3
Weight	0.0	0.2	0.6	0.5	0.1	0.4	-0.4	-0.8
Medication: Paracetamol	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.2	-0.1

Hub : Genes

SOX6

Models

Trait associations