Best TWAS P=2.8e-37 · Best GWAS P=7.22e-69 conditioned to 2.12e-60
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-218M22.1 | 0.38 | 0.29 | lasso | 10 | 0.27 | 3.0e-22 | -5.2 | -5.2 | 2.0e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-218M22.1 | 0.41 | 0.35 | lasso | 5 | 0.34 | 2.1e-18 | -5.2 | -5.2 | 1.9e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | TSPAN9 | 0.54 | 0.43 | enet | 34 | 0.46 | 4.0e-18 | 7.2 | -7.0 | 3.2e-12 | -0.01 | 0.58 | 0.42 | FALSE |
| 4 | GTEx | Artery Aorta | TSPAN9 | 0.25 | 0.26 | lasso | 5 | 0.33 | 5.3e-19 | 7.1 | -7.2 | 6.9e-13 | -0.02 | 0.61 | 0.39 | TRUE |
| 5 | GTEx | Artery Aorta | B4GALNT3 | 0.36 | 0.17 | enet | 27 | 0.25 | 6.3e-14 | 10.1 | -11.2 | 2.7e-29 | -0.06 | 0.08 | 0.92 | FALSE |
| 6 | GTEx | Artery Tibial | B4GALNT3 | 0.49 | 0.24 | enet | 24 | 0.34 | 6.5e-28 | 13.1 | -12.8 | 2.8e-37 | -0.05 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Brain Caudate basal ganglia | RP11-218M22.1 | 0.26 | 0.16 | lasso | 9 | 0.15 | 5.1e-05 | -4.8 | -6.0 | 2.4e-09 | -0.01 | 0.45 | 0.03 | TRUE |
| 8 | GTEx | Brain Cortex | RP11-218M22.1 | 0.25 | 0.05 | enet | 14 | 0.16 | 3.5e-05 | -5.1 | -5.7 | 1.0e-08 | -0.02 | 0.25 | 0.06 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | RP11-218M22.1 | 0.31 | 0.24 | lasso | 4 | 0.25 | 5.0e-13 | -5.2 | -5.4 | 7.1e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | RP11-218M22.1 | 0.14 | 0.01 | enet | 4 | 0.04 | 1.8e-02 | -5.2 | -5.2 | 1.7e-07 | -0.04 | 0.08 | 0.05 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | RP11-218M22.1 | 0.50 | 0.26 | lasso | 7 | 0.37 | 4.8e-29 | 4.0 | -5.7 | 9.7e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Colon Sigmoid | RP11-218M22.1 | 0.48 | 0.24 | lasso | 12 | 0.27 | 4.7e-10 | -5.1 | -5.2 | 1.7e-07 | -0.02 | 0.98 | 0.00 | FALSE |
| 13 | GTEx | Colon Transverse | RP11-218M22.1 | 0.53 | 0.34 | lasso | 8 | 0.35 | 1.3e-17 | -5.1 | -5.5 | 4.5e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Esophagus Gastroesophageal Junction | RP11-218M22.1 | 0.22 | 0.21 | enet | 8 | 0.12 | 5.0e-05 | -5.2 | -5.9 | 2.9e-09 | -0.03 | 0.95 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Mucosa | RP11-218M22.1 | 0.42 | 0.37 | lasso | 7 | 0.40 | 7.4e-29 | -5.2 | -5.4 | 7.0e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Muscularis | TSPAN9 | 0.19 | 0.02 | lasso | 7 | 0.04 | 3.1e-03 | 5.7 | 6.8 | 7.6e-12 | 0.00 | 0.06 | 0.69 | FALSE |
| 17 | GTEx | Esophagus Muscularis | RP11-218M22.1 | 0.47 | 0.45 | lasso | 6 | 0.44 | 1.6e-29 | -5.2 | -5.3 | 1.2e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Heart Atrial Appendage | RP11-218M22.1 | 0.43 | 0.36 | lasso | 7 | 0.36 | 4.5e-17 | -5.1 | -5.3 | 9.3e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Heart Left Ventricle | RP11-218M22.1 | 0.37 | 0.29 | enet | 5 | 0.29 | 1.0e-15 | -5.1 | -5.4 | 7.1e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Lung | RP11-218M22.1 | 0.33 | 0.26 | lasso | 5 | 0.28 | 2.5e-21 | -5.2 | -5.7 | 1.3e-08 | -0.02 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Muscle Skeletal | RP11-218M22.1 | 0.28 | 0.21 | enet | 21 | 0.22 | 3.2e-21 | -5.1 | -5.1 | 2.8e-07 | -0.02 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Nerve Tibial | TSPAN9 | 0.65 | 0.17 | enet | 79 | 0.40 | 4.9e-30 | -5.9 | 7.4 | 1.1e-13 | 0.01 | 0.36 | 0.64 | TRUE |
| 23 | GTEx | Nerve Tibial | RP11-218M22.1 | 0.46 | 0.46 | enet | 12 | 0.46 | 1.2e-35 | -5.2 | -5.3 | 1.1e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Pancreas | RP11-218M22.1 | 0.30 | 0.18 | lasso | 7 | 0.20 | 7.7e-09 | -5.2 | -5.9 | 4.0e-09 | -0.01 | 0.82 | 0.01 | FALSE |
| 25 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-218M22.1 | 0.35 | 0.27 | enet | 30 | 0.27 | 2.4e-15 | -5.1 | -5.7 | 1.5e-08 | 0.01 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Skin Sun Exposed Lower leg | RP11-218M22.1 | 0.30 | 0.18 | lasso | 4 | 0.24 | 8.4e-20 | -5.2 | -5.8 | 5.2e-09 | -0.01 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Spleen | RP11-218M22.1 | 0.47 | 0.45 | lasso | 2 | 0.41 | 8.7e-12 | -5.2 | -5.2 | 1.8e-07 | -0.03 | 0.99 | 0.00 | FALSE |
| 28 | GTEx | Stomach | RP11-218M22.1 | 0.38 | 0.24 | enet | 11 | 0.28 | 4.6e-14 | -5.2 | -5.9 | 4.3e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Testis | ERC1 | 0.32 | 0.04 | lasso | 9 | 0.18 | 1.5e-08 | -6.2 | -6.0 | 2.2e-09 | -0.09 | 0.38 | 0.15 | TRUE |
| 30 | GTEx | Thyroid | RP11-218M22.1 | 0.23 | 0.22 | lasso | 4 | 0.22 | 1.6e-16 | -5.1 | -5.3 | 9.7e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Whole Blood | RP11-218M22.1 | 0.30 | 0.22 | enet | 27 | 0.22 | 2.7e-20 | -5.2 | -5.4 | 7.4e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 32 | METSIM | Adipose | CACNA2D4 | 0.07 | 0.00 | bslmm | 541 | 0.02 | 1.2e-03 | 5.5 | 5.3 | 1.1e-07 | -0.02 | 0.12 | 0.02 | TRUE |
| 33 | ROSMAP | Brain Pre-frontal Cortex | RP11-218M22.1 | 0.32 | 0.28 | lasso | 4 | 0.33 | 7.9e-44 | -5.2 | -5.8 | 8.3e-09 | -0.02 | 1.00 | 0.00 | FALSE |
| 34 | The Cancer Genome Atlas | Colon Adenocarcinoma | WNK1 | 0.08 | 0.03 | lasso | 3 | 0.02 | 2.0e-02 | -5.0 | -5.1 | 2.8e-07 | 0.01 | 0.01 | 0.63 | TRUE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | B4GALNT3 | 0.07 | 0.02 | blup | 119 | 0.06 | 3.4e-07 | 8.3 | 7.6 | 2.5e-14 | 0.09 | 0.00 | 0.98 | FALSE |
| 36 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TSPAN9 | 0.13 | 0.04 | lasso | 3 | 0.02 | 3.3e-02 | 6.2 | -5.9 | 3.0e-09 | -0.03 | 0.10 | 0.18 | FALSE |
| 37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WNK1 | 0.09 | 0.06 | lasso | 2 | 0.05 | 3.5e-06 | -5.0 | -5.1 | 2.7e-07 | 0.01 | 0.01 | 0.98 | FALSE |
| 38 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSPAN9 | 0.06 | 0.00 | blup | 223 | 0.01 | 8.2e-03 | -3.2 | -5.6 | 2.4e-08 | -0.07 | 0.04 | 0.15 | FALSE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | TSPAN9 | 0.36 | 0.27 | enet | 29 | 0.31 | 7.5e-31 | 6.0 | -7.0 | 2.1e-12 | -0.04 | 1.00 | 0.00 | FALSE |