TWAS hub - WNK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0227	0.0093	2.5e-03	0.000	0.009	0.001	0.009	0.001	3.2e-01	3.9e-04	1.1e-01	0.00056	1.3e-01
2	TCGA	Bladder Urothelial Carcinoma	0.0910	0.0370	6.1e-05	0.034	0.041	0.004	NA	0.015	6.4e-04	2.0e-04	1.3e-01	NA	1.7e-02
3	TCGA	Breast Invasive Carcinoma	0.0349	0.0131	4.6e-06	0.024	0.016	0.008	NA	0.019	7.1e-06	2.4e-04	7.9e-03	NA	6.7e-05
4	TCGA	Colon Adenocarcinoma	0.0790	0.0430	9.5e-03	0.029	0.013	0.002	NA	0.022	8.2e-03	5.5e-02	2.2e-01	NA	2.0e-02
5	TCGA	Glioblastoma Multiforme	0.1950	0.0800	6.9e-04	0.070	0.075	0.032	NA	0.026	3.6e-03	2.8e-03	3.8e-02	NA	5.4e-02
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0737	0.0293	1.4e-06	0.034	0.045	0.048	NA	0.059	1.0e-04	7.9e-06	3.8e-06	NA	3.0e-07
7	TCGA	Brain Lower Grade Glioma	0.0892	0.0334	1.1e-06	0.057	0.039	0.043	NA	0.048	4.6e-07	2.8e-05	1.1e-05	NA	3.5e-06
8	TCGA	Lung Adenocarcinoma	0.0542	0.0245	2.6e-04	0.017	0.012	0.002	NA	0.003	3.8e-03	1.4e-02	1.8e-01	NA	1.3e-01
9	TCGA	Lung Squamous Cell Carcinoma	0.0998	0.0414	1.7e-06	0.041	0.044	0.020	NA	0.039	1.7e-05	9.6e-06	2.2e-03	NA	2.6e-05
10	TCGA	Pancreatic Adenocarcinoma	0.1530	0.0560	1.3e-04	0.146	0.049	0.101	NA	0.128	1.0e-06	4.1e-03	5.3e-05	NA	5.1e-06
11	TCGA	Skin Cutaneous Melanoma	0.1910	0.0920	8.5e-03	0.032	0.027	-0.004	NA	0.064	4.9e-02	6.4e-02	4.3e-01	NA	8.5e-03
12	TCGA	Stomach Adenocarcinoma	0.1170	0.0510	1.7e-03	-0.004	0.050	0.028	NA	0.001	7.9e-01	1.7e-04	3.9e-03	NA	2.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Health satisfaction	6.7	8.7	15.1	3.1	3.0	3.5	3.3	3.1	1.6	3.4	3.9	3.3	3.5	0.0	-0.7
Eye problems/disorders: Cataract	6.3	7.3	15.4	0.5	-3.4	-2.8	-3.2	-1.6	-3.9	-3.2	-2.9	-2.9	-2.9	-0.8	-1.8
Commuting to job workplace: Car/motor vehicle	4.8	5.5	7.9	-1.8	-2.0	-2.5	-2.7	-1.6	-2.8	-2.7	-2.4	-2.5	-2.4	-2.5	1.9
Mean Putamen Volume	4.1	4.7	8.9	-2.3	-2.9	-2.0	-2.0	-2.2	-1.3	-2.0	-3.0	-2.3	-2.0	-1.4	-2.0
Hair/balding pattern: Pattern 3	4.1	6.1	9.6	0.6	2.8	3.0	3.0	1.5	2.6	2.9	2.4	2.8	3.1	0.9	2.4
Illness, injury, bereavement, stress in last 2 years	3.9	4.8	7.2	0.7	2.5	2.5	2.7	1.9	2.3	2.7	1.7	2.5	2.5	1.6	1.7
Mouth/teeth dental problems: Mouth ulcers	3.5	5.6	10.8	1.4	3.0	2.8	2.8	0.5	3.3	2.8	1.7	2.5	3.2	0.9	1.0
Medication: Blood pressure	3.4	6.1	10.0	1.4	3.1	2.7	2.9	1.7	2.3	2.9	3.2	2.7	3.1	0.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.1	12.7	-1.4	-2.4	-3.2	-3.0	-3.6	-0.6	-3.1	-3.5	-3.2	-3.1	-0.4	-1.6
Number of full brothers	2.9	3.6	5.5	2.0	2.1	2.3	1.7	2.3	1.1	1.7	1.9	2.4	2.0	-0.8	1.7
Medication: Atenolol	2.8	3.5	6.8	1.4	2.0	2.0	2.2	1.5	1.5	2.2	2.6	2.3	2.1	1.1	-0.2
Number of incorrect matches in round	2.8	4.7	8.3	-1.7	-2.2	-2.6	-2.3	-2.6	-1.2	-2.3	-2.9	-2.6	-2.5	-0.2	-1.0
Age at First Birth	2.7	3.9	6.9	2.6	1.6	2.0	2.3	1.6	1.6	2.3	2.1	2.0	2.3	1.8	-0.9
Vascular/heart problems diagnosed by doctor	2.7	7.4	14.5	-2.4	-3.5	-3.0	-2.8	-2.4	-1.7	-2.9	-3.8	-3.0	-3.0	-2.2	-0.3
Financial situation satisfaction	2.6	3.2	7.2	0.5	2.6	1.6	1.9	2.1	1.5	1.9	2.7	2.2	1.9	0.0	-0.2
Hand grip strength (right)	2.5	6.8	13.9	-0.2	-2.3	-3.2	-3.3	0.0	-3.7	-3.2	-1.0	-3.1	-3.5	1.2	-2.5
Pulse wave reflection index	2.5	3.0	6.8	0.8	2.1	2.0	2.0	1.1	1.5	2.0	2.6	1.5	2.0	1.7	-0.1
Heel T-Score	2.4	19.0	26.4	-3.9	-4.8	-5.1	-5.1	-4.2	-4.7	-5.1	-3.5	-4.8	-5.0	-2.1	-2.5
Shortness of breath walking on level ground	2.3	2.8	5.4	1.3	2.0	2.1	1.7	0.9	1.1	1.7	1.7	2.3	2.1	1.1	1.4
Illnesses of father: High blood pressure	2.3	2.8	4.6	1.6	1.5	2.0	2.1	0.7	1.3	2.1	2.1	1.7	2.1	1.2	-1.0
Basal cell carcinoma (self-reported)	2.3	2.7	5.8	-2.4	-1.3	-1.7	-1.7	-2.1	-0.6	-1.7	-2.3	-1.9	-1.8	0.2	0.0
Number of full sisters	2.2	2.7	4.9	-1.1	-1.1	-2.0	-1.9	-2.0	-1.1	-1.9	-2.2	-2.0	-1.8	-0.0	0.9
Hypertension (Self-reported)	2.2	6.2	15.6	1.8	3.4	2.7	2.5	2.4	1.2	2.5	3.9	2.7	2.7	1.9	0.2
Friendships satisfaction	2.2	2.8	8.4	2.9	1.3	1.4	1.4	2.0	0.1	1.5	2.0	1.2	1.5	0.1	-2.4
HbA1C	2.1	2.3	3.7	-1.0	-1.9	-1.7	-1.8	-1.3	-1.6	-1.8	-1.9	-1.1	-1.7	0.9	-0.4
Number of treatments/medications taken	2.1	3.8	7.3	2.0	2.0	2.7	2.1	2.1	1.2	2.1	1.9	2.3	2.3	0.8	0.6
Medication for hormone replacement therapy	2.1	2.4	4.1	-1.6	-2.0	-1.2	-1.6	-0.9	-1.7	-1.6	-1.8	-1.2	-1.6	-2.0	-0.2
Chronic bronchitis/emphysema (father)	2.1	2.5	6.7	-1.2	-2.2	-1.4	-1.3	-0.9	-1.7	-1.3	-2.2	-1.2	-1.2	-2.6	0.5
Ever had prostate specific antigen (PSA) test	2.1	2.4	8.6	-0.3	2.4	1.8	1.1	1.1	1.1	1.1	1.5	1.6	1.2	0.5	2.9
BMI	2.0	11.4	53.3	7.3	2.7	2.4	2.1	5.3	-0.5	2.1	2.4	0.6	1.9	2.7	-4.0
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	4.6	1.9	1.7	1.8	1.5	2.1	0.9	1.5	1.9	2.0	1.4	-1.0	0.8
Migraine (self-reported)	2.0	2.5	4.5	-1.0	-1.5	-1.9	-2.1	-0.6	-1.8	-2.1	-1.4	-1.7	-2.0	-1.4	-0.4
Illnesses of father: None of the above (group 1)	2.0	2.4	4.1	0.1	-1.9	-1.7	-1.8	-0.1	-1.8	-1.8	-2.0	-1.9	-1.8	0.7	-1.2
Medication: Bendroflumethiazide	2.0	3.0	6.4	-0.3	1.8	2.0	2.1	-0.4	1.9	2.1	2.5	1.8	2.3	0.5	-0.8
Coronary Artery Disease (CAD)	1.9	2.3	6.4	-0.3	-1.0	-1.8	-1.4	0.0	-2.5	-1.4	0.8	-1.1	-1.4	-2.5	-1.7
High blood pressure	1.9	5.3	13.2	1.9	3.0	2.5	2.3	2.2	1.1	2.3	3.6	2.4	2.5	1.6	-0.2
Medication: Ramipril	1.9	2.4	6.0	1.0	1.7	2.1	1.7	1.4	0.8	1.7	2.5	1.5	2.0	0.5	-0.6
Number of self-reported non-cancer illnesses	1.9	3.3	7.5	2.2	1.7	2.1	1.8	1.7	0.3	1.8	2.7	1.9	2.1	1.1	-1.5
Crohns Disease (2012)	1.8	2.9	6.3	-2.3	-2.2	-1.4	-1.3	-1.1	-2.1	-1.3	-1.1	-1.5	-1.2	-1.6	-2.5
Medication: Simvastatin	1.8	2.7	5.8	1.9	2.4	1.8	1.4	1.7	0.8	1.4	2.2	1.8	1.7	0.9	0.2
Medication: Aspirin	1.8	2.3	5.2	2.3	2.0	1.5	1.5	1.5	1.0	1.5	1.6	1.5	1.9	-0.4	-0.1
Medication: Blood pressure	1.8	3.4	7.8	2.0	2.0	2.2	1.7	1.2	1.0	1.7	2.8	1.9	1.8	1.8	-1.3
Ulcerative Colitis (UC)	1.7	3.1	6.1	1.9	2.1	2.5	1.8	1.7	0.6	1.8	1.4	1.5	2.1	-0.1	2.3
Rheumatoid Arthritis	1.7	2.3	5.5	2.4	1.0	1.7	1.8	2.0	1.3	1.8	0.8	1.3	1.8	1.0	-0.2
Mouth/teeth dental problems	1.7	2.6	5.6	-0.4	-1.9	-2.4	-1.5	-1.2	-0.8	-1.5	-1.9	-2.3	-2.2	-1.0	-0.0
Body Mass Index (BMI) (2010)	1.6	2.2	5.6	2.3	1.7	1.5	1.3	2.4	0.7	1.3	0.9	0.9	1.2	1.7	-0.4
Schizophrenia (2014)	1.6	3.4	7.3	1.2	1.9	2.1	1.9	1.6	2.0	1.8	1.9	1.5	1.6	2.7	-1.6
Cardiovascular Disease	1.6	5.4	22.0	1.2	3.0	2.3	1.9	2.4	0.2	2.0	4.7	2.3	2.1	1.6	-1.3
Relative age of first facial hair	1.6	3.3	9.4	-2.0	-2.0	-2.2	-1.7	-0.4	-1.8	-1.7	-1.1	-1.5	-2.0	-3.1	0.2
Townsend deprivation index at recruitment	1.6	2.2	4.3	-0.0	2.1	1.4	1.7	1.6	1.3	1.7	1.7	1.8	1.8	0.6	1.0
Supplements: Glucosamine	1.6	2.1	6.2	0.0	1.8	2.5	1.7	0.8	1.6	1.7	1.1	1.3	1.9	0.1	0.8
Body mass index (BMI)	1.6	6.8	30.6	5.5	2.3	1.9	1.6	4.1	-0.3	1.6	1.9	0.7	1.6	1.9	-3.1
Fluid intelligence score	1.6	3.2	9.7	1.7	2.1	1.7	1.6	2.1	0.1	1.6	3.1	1.4	1.7	1.5	-1.5
Impedance of leg (right)	1.5	7.1	53.3	-7.3	-1.9	-1.1	-0.8	-3.6	1.2	-0.9	-1.8	-0.2	-0.8	-2.0	1.7
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	5.7	-1.0	-2.4	-1.6	-1.6	-1.2	-1.2	-1.6	-2.1	-1.4	-1.8	-1.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.9	-0.6	-2.1	-0.8	-1.1	-0.3	-2.6	-1.1	-0.6	-1.1	-0.6	-1.3	-1.9
Leg pain on walking	1.5	1.9	3.7	-0.9	1.9	1.3	1.2	0.2	1.5	1.2	0.9	1.5	1.4	1.8	1.7
Supplements: Vitamin C	1.5	1.8	3.3	-1.5	-0.9	-1.2	-1.6	-1.4	-0.7	-1.6	-1.5	-1.8	-1.6	0.9	-0.5
Commuting to job workplace: Walk	1.5	1.6	3.0	1.4	1.2	1.1	1.6	1.0	1.7	1.6	1.1	1.4	1.5	0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	6.8	1.5	-1.6	-1.0	-1.0	-0.3	-1.7	-1.0	-1.0	-0.8	-0.9	-2.6	-0.9
Risk taking	1.5	2.1	4.1	1.3	-1.5	-1.3	-1.4	-1.2	-1.2	-1.4	-1.9	-2.0	-1.6	-0.7	-1.5
Sensitivity / hurt feelings	1.4	2.4	8.3	-2.3	-1.6	-0.9	-1.0	-2.9	0.3	-1.0	-1.9	-0.7	-0.8	1.5	-1.5
Medication: Co-codamol	1.4	1.6	2.7	1.2	1.3	1.5	1.3	0.9	1.5	1.3	0.2	1.6	1.4	0.7	1.4
Had menopause	1.4	1.8	6.8	2.1	-1.2	-0.7	-0.9	0.6	-1.5	-0.8	-0.7	-1.4	-0.7	1.0	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	9.3	-1.5	-2.2	-2.5	-2.2	-2.4	-0.3	-2.3	-3.0	-2.6	-2.7	-1.2	-1.0
Length of working week for main job	1.4	1.6	4.1	2.0	-1.2	-0.8	-0.7	0.5	-2.0	-0.7	-0.4	-1.2	-0.7	-1.8	-1.5
Emphysema/chronic bronchitis	1.4	1.6	3.0	-1.7	-1.3	-1.2	-1.3	-1.6	-1.2	-1.3	-0.9	-0.7	-1.0	-1.7	-0.0
Overall health rating	1.4	3.0	6.0	0.6	1.8	2.1	2.1	1.8	1.2	2.1	2.4	2.1	2.1	0.0	-0.6
Ever had bowel cancer screening	1.4	1.6	3.8	0.6	1.4	1.9	1.4	0.6	1.0	1.4	1.2	1.8	1.6	0.4	0.5
Osteoarthritis (self-reported)	1.4	1.8	2.9	0.9	1.2	1.7	1.5	1.6	0.7	1.5	1.7	1.2	1.6	-0.1	-1.7
Alzheimer’s Disease (in mother)	1.3	1.5	6.4	2.1	-0.8	0.1	-0.4	1.3	-1.3	-0.4	-0.8	-0.0	-0.2	2.5	-1.4
Impedance of leg (left)	1.3	6.3	46.3	-6.8	-1.9	-1.1	-0.8	-3.4	1.0	-0.8	-1.7	-0.3	-0.8	-2.3	1.4
Waist circumference	1.3	4.8	17.6	4.2	2.1	1.7	1.3	4.0	-0.6	1.3	1.6	0.7	1.4	1.7	-2.3
Arm fat percentage (right)	1.3	5.2	14.3	3.6	2.6	2.2	2.0	3.8	0.4	2.0	2.1	1.1	2.0	1.1	-2.1
Happiness	1.3	1.5	3.0	1.7	1.4	0.9	1.2	1.3	0.1	1.2	1.7	1.4	1.4	0.9	-0.2
Arm fat mass (right)	1.3	5.5	19.0	4.4	2.3	1.9	1.4	4.3	-0.4	1.4	1.8	0.5	1.4	1.4	-2.8
Family relationship satisfaction	1.3	1.6	9.9	3.1	0.5	0.7	0.8	1.6	-0.8	0.8	0.9	0.6	1.0	0.6	-1.1
Arm fat mass (left)	1.3	5.5	19.6	4.3	2.2	1.8	1.4	4.4	-0.4	1.4	1.8	0.5	1.3	1.3	-2.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.8	0.5	1.0	1.5	1.7	0.6	1.9	1.7	0.8	1.3	1.4	-1.2	0.1
Impedance of whole body	1.3	6.8	52.5	-7.2	-1.5	-0.7	-0.4	-3.2	1.3	-0.4	-1.1	0.2	-0.3	-3.0	1.9
Schizophrenia (2018)	1.2	2.4	4.7	1.3	1.6	2.0	1.5	1.4	1.7	1.4	1.3	1.3	1.1	2.2	-1.5
Alzheimer’s Disease (including proxy)	1.2	1.7	8.6	2.9	-0.2	0.6	0.3	1.5	-0.8	0.3	0.2	0.5	0.3	2.5	-1.5
Ulcerative Colitis	1.2	1.8	2.9	0.9	1.7	1.4	1.4	1.7	0.4	1.4	1.5	1.3	1.4	0.5	1.6
Serious illness, injury or assault to yourself	1.2	1.5	3.1	-1.0	-1.4	-1.1	-1.6	-1.3	-0.9	-1.6	-0.7	-1.5	-1.8	-0.3	-0.5
Hip circumference	1.2	5.0	17.3	4.2	1.9	1.8	1.1	3.8	-0.6	1.2	1.6	0.4	1.1	2.1	-3.3
Alcohol intake versus 10 years previously	1.2	1.8	5.9	-0.1	1.3	1.7	1.1	2.4	0.6	1.2	1.6	1.8	1.1	-1.3	0.2
Gout (self-reported)	1.2	1.7	2.9	-0.2	-1.5	-1.1	-1.4	-1.3	-1.3	-1.4	-1.0	-1.3	-1.3	-1.7	-1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.9	0.3	1.7	1.6	1.0	1.5	0.7	1.0	1.5	1.5	1.1	-0.5	1.1
Heart disease (mother)	1.2	1.4	3.7	1.9	1.4	1.1	1.1	1.7	0.7	1.1	1.5	1.1	0.9	0.5	0.3
Medication: Aspirin	1.2	1.6	3.3	1.6	1.8	1.3	1.3	0.9	1.1	1.3	1.4	1.2	1.6	0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.6	-1.3	-1.3	-0.7	-0.7	-1.2	-1.0	-0.7	-0.6	-1.0	-0.7	-1.9	-1.6
Back pain experienced in last month	1.2	1.8	4.1	-0.6	0.8	1.6	1.9	0.0	2.0	1.9	0.2	1.8	1.7	-0.3	0.7
Leg fat mass (left)	1.2	4.6	16.2	3.8	1.9	1.6	1.1	4.0	-0.7	1.2	1.6	0.3	1.2	1.1	-3.1
Bipolar Disorder or Schizophrenia	1.1	2.7	5.4	1.0	1.9	2.0	1.8	1.0	1.8	1.7	1.6	1.6	1.5	2.3	-0.7
Major Depression (MDD)	1.1	1.4	3.2	-0.3	1.4	1.4	1.4	1.0	0.9	1.4	1.8	1.3	1.2	-0.3	0.6
Blood White Count	1.1	8.4	18.2	0.3	-4.3	-3.0	-2.9	-1.5	-3.5	-2.9	-2.9	-3.0	-2.9	-1.0	-3.9
Average weekly spirits intake	1.1	1.4	3.2	0.3	-1.2	-1.1	-1.3	-0.4	-1.5	-1.3	-1.1	-1.4	-1.4	0.2	-1.8
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.0	1.4	1.9	1.6	1.3	2.5	0.3	1.3	2.0	1.8	1.5	0.1	1.2
Nervous feelings	1.1	2.1	6.1	-2.5	0.6	0.9	1.0	-1.2	2.4	1.0	0.3	2.0	0.8	1.1	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	5.5	1.7	1.2	0.8	0.7	0.4	0.7	0.7	0.8	1.4	0.7	2.3	1.2
Wheeze or whistling in the chest in last year	1.1	1.9	4.8	1.8	0.9	1.8	1.3	2.2	0.4	1.3	1.9	1.6	1.4	-0.2	-0.1
Suffer from ‘nerves’	1.1	1.7	4.5	-1.7	0.9	0.7	0.9	-1.5	2.1	0.8	0.3	1.2	0.8	1.9	1.7
Arm fat percentage (left)	1.1	4.3	12.3	3.5	2.1	1.8	1.6	3.5	0.0	1.6	1.8	0.8	1.6	1.0	-2.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.3	1.1	1.2	1.1	1.4	0.5	1.1	1.4	1.5	1.5	1.3	1.1	-0.2
Alzheimer’s Disease (in father)	1.0	1.1	3.3	1.8	0.8	1.0	1.1	0.5	0.8	1.1	1.3	1.2	1.0	0.9	0.2
Crohns Disease (2017)	1.0	2.3	5.9	-1.4	-1.9	-1.3	-1.6	-0.8	-2.4	-1.6	-1.1	-1.5	-1.5	-0.2	-1.6
Hearing difficulty/problems: Yes	1.0	1.5	2.7	0.1	-1.3	-1.4	-1.2	-1.4	-1.4	-1.2	-1.2	-1.6	-1.2	-0.6	-1.1
Age when periods started (menarche)	1.0	2.4	12.0	-3.5	-1.0	-1.4	-1.1	-1.8	0.0	-1.1	-1.6	-0.4	-1.0	-0.7	1.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	5.6	-0.7	-1.6	-0.8	-0.5	-2.4	-0.1	-0.6	-1.1	-0.7	-0.6	-1.4	0.3
Heart attack	1.0	1.3	2.0	1.1	1.3	1.1	1.3	0.4	1.1	1.3	1.4	1.4	1.3	1.0	-0.1
Allergy	1.0	2.2	4.4	-0.8	-1.7	-2.0	-1.3	-2.1	-0.6	-1.4	-1.9	-2.1	-1.7	0.3	-0.1
Impedance of arm (right)	1.0	4.9	36.5	-6.0	-0.3	0.2	0.5	-2.0	1.6	0.4	0.1	0.7	0.6	-2.9	2.3
Illnesses of mother	1.0	1.2	6.4	-2.5	-0.2	-0.7	-0.3	-1.2	0.7	-0.3	-0.5	-0.5	-0.5	-1.9	1.3
Impedance of arm (left)	1.0	4.6	37.2	-6.1	-0.7	0.1	0.3	-2.2	1.5	0.2	-0.2	0.7	0.5	-2.7	1.6
Breastfed as a baby	1.0	1.2	2.3	0.6	-1.3	-1.4	-1.0	-0.9	-0.7	-1.0	-1.5	-1.5	-1.5	-0.5	0.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.3	-1.4	-1.2	-1.0	-1.1	-1.6	-1.6	-1.1	0.4	-1.0	-0.9	-1.1	-2.1
Comparative body size at age 10	1.0	2.9	20.8	4.6	0.7	0.8	0.5	1.1	-0.7	0.5	0.2	-1.1	0.4	1.4	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	-0.2	-1.5	-0.9	-0.9	-1.1	-0.7	-0.9	-1.3	-1.3	-0.9	-0.5	-1.8
Leg fat mass (right)	1.0	4.0	14.1	3.8	1.7	1.5	1.0	3.7	-0.7	1.0	1.3	0.2	1.0	1.1	-3.0
Medication: Gliclazide	1.0	1.2	4.4	2.1	0.8	0.6	0.8	1.8	0.3	0.8	0.4	0.2	0.9	1.7	-0.6
Miserableness	1.0	1.7	9.8	-3.1	-0.8	-1.1	-1.1	-1.3	-0.4	-1.1	-1.4	-0.7	-0.9	0.1	1.0
Supplements: Fish oil (including cod liver oil)	1.0	1.4	5.6	-0.8	-1.1	-0.7	-1.1	-0.4	-0.4	-1.2	-2.4	-1.3	-1.1	-0.8	1.3
Commuting to job workplace: Cycle	1.0	1.2	1.6	1.2	1.1	1.0	1.2	0.9	1.3	1.2	1.2	0.8	1.2	0.5	-1.1
Cholesterol lowering medication	1.0	1.4	5.2	1.9	0.8	0.6	0.6	1.0	-0.1	0.6	2.3	0.8	0.7	0.2	-2.2
Fasting Glucose	0.9	1.0	3.3	-1.3	-1.1	-0.9	-0.9	-0.8	-0.6	-0.9	-0.8	-0.7	-0.9	-0.6	-1.8
Relative age voice broke	0.9	1.4	2.6	-1.5	-1.4	-1.6	-1.2	-0.4	-1.4	-1.2	-0.4	-1.0	-1.2	-1.5	-0.1
Sitting height	0.9	6.7	11.5	-2.4	-2.5	-2.9	-3.2	-0.1	-3.1	-3.2	-2.4	-2.9	-3.4	-1.5	-1.3
Weight	0.9	4.6	19.6	4.2	1.4	1.1	0.6	4.4	-1.3	0.6	1.1	-0.3	0.4	1.3	-3.1
Worrier / anxious feelings	0.9	1.8	7.4	-2.2	-1.4	-1.0	-0.8	-2.7	0.4	-0.8	-1.2	0.1	-0.8	1.2	-1.1
Forced vital capacity (FVC), Best measure	0.9	3.4	6.4	-0.1	-2.1	-2.2	-2.1	-1.6	-0.7	-2.1	-2.5	-2.4	-2.5	-0.4	-1.2
Arm fat-free mass (right)	0.9	4.4	17.0	4.1	-0.3	-0.7	-1.2	3.3	-2.8	-1.2	-0.3	-1.7	-1.6	1.0	-2.8
Exposure to tobacco smoke outside home	0.9	1.2	6.7	-2.6	-0.7	-0.5	-0.7	-0.8	-0.1	-0.7	-1.4	-0.1	-0.6	-0.2	1.7
Arm predicted mass (right)	0.9	4.5	16.6	4.1	-0.3	-0.8	-1.4	3.1	-2.9	-1.3	-0.3	-1.8	-1.6	0.9	-2.7
Leg fat-free mass (right)	0.9	4.9	25.0	5.0	1.1	0.5	0.0	4.4	-2.1	0.1	1.1	-0.6	-0.1	0.8	-2.4
Loneliness, isolation	0.9	1.3	3.7	-0.8	-1.1	-1.1	-1.3	-1.9	-1.3	-1.3	-0.5	-1.1	-1.0	-0.5	-0.9
Leg predicted mass (right)	0.9	4.9	25.5	5.0	1.2	0.6	0.0	4.4	-2.1	0.1	1.1	-0.6	-0.1	0.8	-2.4
Medication: Paracetamol	0.9	1.4	2.9	1.4	0.9	1.4	1.4	1.7	1.0	1.4	0.6	1.2	1.4	0.1	-0.5
Leg fat percentage (left)	0.9	3.2	8.8	2.6	1.8	1.6	1.4	2.6	0.1	1.4	1.6	0.6	1.5	1.0	-3.0
Unable to work because of sickness or disability	0.9	1.2	2.8	-0.7	-0.6	-1.3	-1.6	-0.2	-0.8	-1.6	-1.6	-0.9	-1.7	-0.0	0.3
HDL Cholesterol	0.8	1.3	3.0	0.1	-1.1	-1.5	-1.2	-0.9	-1.6	-1.2	-0.8	-1.1	-1.1	-1.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.1	0.8	0.9	1.1	1.2	1.4	1.1	0.2	1.1	0.9	0.8	-0.0
Severe depression (siblings)	0.8	0.9	1.6	0.2	0.7	0.8	1.2	0.8	0.8	1.2	1.1	1.0	1.1	1.3	-0.3
Leg fat-free mass (left)	0.8	4.5	20.7	4.6	1.2	0.6	0.0	4.4	-2.0	0.0	1.0	-0.6	-0.1	1.0	-2.2
Trunk fat percentage	0.8	3.4	11.6	1.8	1.9	1.9	1.5	3.4	0.1	1.6	1.7	0.9	1.6	0.7	-2.7
Qualifications: CSEs or equivalent	0.8	1.0	6.3	-0.7	1.1	0.5	0.4	1.1	0.5	0.4	0.6	1.2	0.5	-0.0	2.5
High blood pressure (mother)	0.8	1.1	2.8	0.7	1.1	1.2	1.2	0.5	0.6	1.2	1.0	0.9	1.4	1.7	0.2
Leg predicted mass (left)	0.8	4.4	20.4	4.5	1.1	0.5	-0.1	4.4	-2.1	-0.0	1.0	-0.6	-0.2	1.0	-2.2
Trunk fat mass	0.8	3.6	14.9	2.7	1.6	1.5	1.0	3.9	-0.7	1.0	1.4	0.2	1.0	0.9	-3.1
Past tobacco smoking	0.8	1.4	6.9	0.0	0.9	0.9	1.1	0.4	1.6	1.1	-0.2	0.7	0.8	1.5	2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.8	-0.5	-2.0	-1.8	-1.3	-1.5	-1.2	-1.3	-1.2	-1.5	-1.5	-1.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.4	0.3	0.2	1.5	1.4	0.4	1.0	1.4	-0.4	1.1	1.5	0.3	1.1
Asthma	0.8	1.6	4.0	0.1	1.3	1.7	1.1	1.9	0.2	1.1	1.8	2.0	1.3	-0.1	0.4
Depression (self-reported)	0.8	0.9	1.8	-0.2	-0.8	-1.3	-1.3	-0.7	-1.3	-1.3	-0.8	-1.1	-0.9	0.4	-0.4
Medication: Lansoprazole	0.8	0.9	1.9	0.9	1.0	1.2	1.2	0.8	1.0	1.2	1.4	0.6	1.1	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.5	1.1	0.3	1.1	1.0	1.2	-0.2	1.1	-0.1	1.2	1.2	1.0	0.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	4.5	1.7	0.4	0.3	0.4	2.1	-1.0	0.4	1.0	0.3	0.6	-0.8	0.1
Body fat percentage	0.8	3.1	9.6	2.2	1.8	1.7	1.4	3.1	0.1	1.4	1.5	0.6	1.5	0.7	-2.7
Pulse wave peak to peak time	0.8	0.9	1.8	0.3	-1.1	-0.8	-1.2	-1.2	-1.2	-1.2	-1.3	-0.5	-1.1	-0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	-0.6	-1.3	-0.7	-1.0	-1.1	-0.9	-1.0	-1.0	-0.8	-0.9	1.4	-0.7
Whole body fat mass	0.8	3.5	13.8	3.2	1.5	1.3	0.8	3.7	-0.8	0.8	1.2	-0.0	0.8	0.7	-3.1
Age at last live birth	0.8	1.1	3.3	1.7	0.9	0.3	1.1	0.6	1.0	1.1	0.9	1.0	0.8	1.8	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.4	0.3	-1.6	-1.0	-0.8	-1.2	-0.8	-0.8	-0.6	-1.1	-1.1	0.7	-0.9
Average weekly champagne plus white wine intake	0.8	1.2	3.5	-0.2	-1.0	-1.4	-1.0	-0.7	-1.0	-1.0	-0.3	-0.8	-1.2	-1.9	-1.3
Wears glasses or contact lenses	0.8	0.9	3.1	0.4	0.4	0.8	1.4	0.2	1.8	1.4	-0.1	1.0	1.2	1.1	-0.2
Hearing aid user	0.8	0.9	1.8	1.0	1.0	1.2	1.2	0.7	1.3	1.2	0.4	1.0	1.1	-0.2	0.2
Mother’s age at death	0.8	1.0	3.2	0.6	0.9	0.7	0.8	0.8	0.8	0.8	1.6	0.8	0.6	-1.0	-1.8
Basal metabolic rate	0.8	4.2	18.5	4.3	0.8	0.2	-0.4	4.1	-2.3	-0.4	0.5	-1.0	-0.6	1.1	-2.3
Arm fat-free mass (left)	0.8	3.8	13.1	3.6	0.0	-0.5	-1.1	3.4	-2.7	-1.1	-0.2	-1.7	-1.3	0.8	-2.6
Fractured/broken bones in last 5 years	0.8	1.0	5.7	-0.8	-0.4	-0.4	-0.4	-0.9	0.1	-0.4	-1.3	0.0	-0.3	-1.7	2.4
Arm predicted mass (left)	0.8	3.9	15.4	3.9	0.2	-0.4	-0.9	3.6	-2.6	-0.9	-0.0	-1.4	-1.1	1.1	-2.4
Verbal and Numeric Reasoning (VNR)	0.7	1.8	6.4	1.2	1.9	1.4	1.0	1.4	-0.2	1.0	2.5	0.9	1.2	1.3	-0.6
Hand grip strength (left)	0.7	1.9	3.9	0.8	-0.8	-1.5	-1.5	0.7	-2.0	-1.4	-0.1	-1.7	-1.7	1.7	-1.4
Diabetes (father)	0.7	0.8	2.3	-0.1	1.2	1.1	1.1	0.3	1.2	1.1	1.5	0.7	0.9	0.1	0.0
Stomach or abdominal pain in last month	0.7	0.8	2.3	1.0	-0.7	-0.3	-1.0	0.5	-1.4	-0.9	-0.3	-0.3	-0.7	-1.0	-1.5
Medication: Levothyroxine sodium	0.7	1.2	2.7	-1.2	-1.1	-0.9	-0.9	-1.2	-0.3	-0.9	-1.3	-1.2	-1.0	0.7	-1.6
Forced vital capacity (FVC)	0.7	2.7	5.4	-0.4	-1.6	-2.0	-2.0	-1.3	-0.6	-2.0	-2.2	-2.1	-2.3	-0.9	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.1	2.6	1.0	0.6	1.5	0.5	1.6	-0.6	0.5	1.6	1.4	1.1	0.6	-0.8
Lung cancer (father)	0.7	0.8	5.2	0.3	-0.4	-0.3	-0.8	0.5	-0.2	-0.8	-2.3	-1.1	-0.8	1.0	0.2
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	-0.4	1.1	0.7	1.0	1.4	1.1	1.0	1.2	0.4	0.9	0.1	0.6
Medication: Paracetamol	0.7	1.1	2.2	0.5	0.8	1.2	1.4	1.5	0.9	1.4	0.6	1.3	1.3	-0.1	-1.0
Leg fat percentage (right)	0.7	2.5	6.7	2.2	1.6	1.5	1.3	2.3	0.2	1.3	1.2	0.5	1.4	1.1	-2.6
Medication: Seretide 50 evohaler	0.7	0.8	3.4	-0.0	0.2	0.3	0.0	1.3	-1.2	0.0	1.9	0.4	0.0	-1.2	-1.0
Chest pain or discomfort	0.7	1.0	2.9	-1.2	-1.2	-0.9	-0.9	-1.1	-1.4	-0.9	0.1	-0.1	-0.9	-1.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.4	-1.3	-0.8	-1.3	-1.6	1.0	-1.8	-1.6	-0.5	-1.1	-1.8	0.5	-0.1
Whole body fat-free mass	0.7	4.2	18.3	4.3	0.4	-0.2	-0.9	3.8	-2.6	-0.8	0.3	-1.3	-1.1	0.9	-2.2
Medication for cholesterol	0.7	1.1	2.5	-0.6	-0.9	-1.6	-1.0	-0.8	-0.5	-1.0	-1.4	-1.3	-1.1	-0.1	1.2
Asthma (self-reported)	0.7	1.5	3.6	0.0	1.3	1.6	1.0	1.9	0.2	1.0	1.7	1.9	1.1	0.1	0.3
Whole body water mass	0.7	4.2	18.6	4.3	0.3	-0.3	-0.8	3.8	-2.6	-0.8	0.2	-1.4	-1.1	0.9	-2.3
Ever taken oral contraceptive pill	0.7	0.7	2.5	0.5	-0.3	-1.1	-1.0	0.3	-1.6	-1.0	-0.3	-1.2	-1.0	0.3	-0.4
Supplements: Calcium	0.7	0.8	4.7	-2.2	-0.5	-0.4	-0.8	0.4	-0.4	-0.8	-1.4	-0.4	-0.6	0.2	0.6
Heart disease (siblings)	0.7	0.9	1.6	1.2	1.2	1.1	0.9	0.3	1.3	0.9	1.2	0.8	0.7	0.9	0.5
Neuroticism (Nagel 2018)	0.6	1.4	5.9	-2.0	-0.2	0.4	0.5	-2.4	1.5	0.5	-0.3	0.9	0.5	1.7	0.1
Worry (Nagel 2018)	0.6	1.3	4.9	-2.2	-0.1	0.3	0.3	-2.2	1.5	0.2	-0.1	1.0	0.1	1.3	1.0
Neuroticism (2016)	0.6	0.8	6.2	-1.4	0.6	0.3	0.1	-0.4	0.5	0.1	-0.1	0.6	-0.1	0.7	2.5
Allergy or Eczema	0.6	1.6	3.4	1.6	1.3	1.2	0.9	1.8	0.1	0.9	1.4	1.4	1.2	0.0	1.6
Lung FVC	0.6	2.9	8.8	1.1	-1.6	-1.7	-1.6	-3.0	0.1	-1.6	-2.6	-1.8	-1.8	-0.2	-0.3
Chronotype (morning person)	0.6	1.5	5.7	0.8	-1.2	-0.9	-0.8	0.0	-0.7	-0.8	-1.0	-1.5	-1.0	-1.8	-2.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-0.9	-0.8	-0.8	-1.2	-0.6	-1.1	-1.2	-1.1	-0.8	-0.9	-0.0	0.3
Angina	0.6	0.8	4.0	2.0	0.5	0.5	0.7	0.2	0.2	0.7	0.8	0.7	0.4	1.6	-0.8
Current tobacco smoking	0.6	0.9	3.9	1.0	-0.7	-0.3	0.0	1.4	-0.9	0.1	0.5	0.1	0.0	-1.7	-2.0
Fed-up feelings	0.6	1.0	3.8	-2.0	0.2	0.7	0.7	-1.2	1.1	0.7	0.3	0.8	0.9	1.3	-1.2
Qualifications: None of the above	0.6	1.2	7.5	-0.6	0.5	1.0	0.7	0.0	1.6	0.7	-0.7	0.8	0.8	-0.5	2.7
Diabetes (self-reported)	0.6	0.9	3.0	1.7	0.9	0.6	0.7	1.7	0.8	0.7	0.6	0.3	0.4	0.3	-1.3
Trunk fat-free mass	0.6	3.7	13.0	3.6	-0.0	-0.7	-1.3	3.2	-2.8	-1.3	-0.1	-1.6	-1.6	0.8	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	4.3	-0.9	-1.3	-1.7	-1.7	-1.3	-0.1	-1.7	-2.1	-1.8	-2.0	-1.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.1	1.6	1.4	1.4	1.1	0.3	0.8	1.1	1.8	0.9	0.9	1.4	-0.7
Trunk predicted mass	0.6	3.7	12.5	3.5	-0.0	-0.7	-1.4	3.2	-2.8	-1.3	-0.1	-1.7	-1.7	0.7	-1.9
Tense / ‘highly strung’	0.6	1.0	2.8	-0.5	1.1	1.2	0.7	-0.6	1.3	0.7	0.9	1.7	0.8	0.9	1.0
Number of children fathered	0.6	0.6	1.7	0.7	-0.5	-0.8	-0.9	-0.2	-1.0	-0.9	-0.4	-1.3	-0.9	-0.5	-1.0
Age at first live birth	0.6	1.1	6.7	2.6	0.4	-0.0	0.4	0.4	0.4	0.5	0.3	0.1	0.3	2.4	-0.6
Eye problems/disorders: None of the above	0.6	0.7	3.0	-1.7	-0.2	-1.1	-0.4	-0.9	0.2	-0.4	0.2	-0.6	-0.5	-1.2	0.8
Medication: Allopurinol	0.6	0.8	1.5	-0.6	-0.6	-0.7	-1.1	-0.5	-0.9	-1.1	-0.5	-1.0	-0.9	-1.2	-1.1
Qualifications: nursing, teaching	0.6	1.0	4.3	-0.6	1.5	0.9	0.5	0.8	-0.4	0.5	2.1	0.9	0.7	1.2	-0.3
Ever smoked	0.6	1.0	3.1	0.1	-0.6	-0.9	-1.0	0.4	-1.6	-1.0	0.3	-0.1	-0.5	-1.8	-1.5
Average weekly beer plus cider intake	0.6	0.8	4.1	-2.0	-0.8	-1.1	-0.8	-1.2	-0.7	-0.8	0.1	-0.1	-0.9	-0.1	-0.2
Alcohol drinker status: Previous	0.6	0.6	1.1	-0.8	-0.7	-0.5	-1.1	-0.7	-0.8	-1.1	-0.5	-1.0	-0.9	-0.8	-0.5
Bipolar Disorder (2018)	0.5	0.8	1.9	0.0	1.0	0.6	1.0	-0.1	0.8	1.0	0.9	0.8	1.0	1.4	0.8
Lupus	0.5	0.8	2.0	-0.2	-0.7	-0.9	-1.1	-0.6	-0.8	-1.1	-1.0	-1.4	-1.0	-1.2	-0.1
Triglycerides	0.5	0.8	3.7	-0.1	0.7	1.2	0.8	1.9	0.4	0.8	0.5	1.1	0.6	0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.2	-0.5	0.0	0.3	0.4	1.3	-0.7	0.4	0.6	0.0	0.4	-1.8	-0.5
Systolic Blood Pressure	0.5	2.4	10.4	-1.8	0.9	1.1	1.6	0.1	0.9	1.6	3.2	1.8	1.5	-1.1	-0.7
Smoking Status	0.5	1.2	8.3	0.9	-0.5	-0.3	-0.2	0.5	-0.7	-0.2	1.0	-0.4	-0.1	-1.8	-2.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.5	1.5	-0.3	0.7	0.5	-0.7	0.4	0.5	-0.4	0.0	0.8	1.6	-0.9
Medication: Metformin	0.5	0.8	2.6	1.6	0.1	-0.6	-0.6	1.1	-0.8	-0.6	-0.8	-0.8	-0.5	0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.1	-1.5	-1.4	-1.2	-1.3	-1.4	-1.2	-0.9	-1.1	-1.1	-0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.6	1.9	-0.1	0.6	0.6	-0.4	0.8	0.6	0.1	0.2	0.3	-1.1	-0.0
Hearing difficulty/problems with background noise	0.5	0.9	2.8	-0.8	-1.1	-0.7	-0.8	-1.1	-1.4	-0.8	-0.0	-0.3	-0.6	-1.7	-0.5
Had other major operations	0.5	0.6	3.0	1.7	0.6	0.7	0.6	0.5	0.3	0.6	0.7	0.4	0.5	-0.0	-0.9
Neuroticism score	0.5	1.0	4.5	-2.1	-0.3	-0.2	-0.5	-2.1	0.4	-0.5	-0.3	0.2	-0.3	1.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	5.1	-0.6	-0.7	-0.5	-0.7	-0.4	-1.0	-0.7	0.3	-0.5	-0.7	-2.3	-0.1
Falls in the last year	0.5	0.7	3.0	1.7	1.0	1.1	0.7	0.2	0.6	0.7	0.8	0.9	0.7	-0.5	0.2
Number of live births	0.5	0.7	3.7	-0.0	-0.7	-0.7	-0.5	-0.6	-0.6	-0.5	-0.5	-0.9	-0.7	0.9	-1.9
Medication: Cholesterol lowering	0.5	0.8	3.1	1.2	1.2	0.8	0.8	0.3	0.5	0.8	0.4	0.6	0.8	1.8	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.0	1.1	0.7	0.9	0.9	0.1	0.6	0.9	0.4	1.1	1.1	0.8	1.4
Medication: Amlodipine	0.5	0.6	2.7	0.3	0.8	0.6	0.5	1.1	-0.1	0.5	1.7	1.1	0.6	0.4	-0.2
Birth weight	0.5	1.2	8.2	-0.5	0.9	0.9	0.3	1.6	0.1	0.3	-0.3	0.5	0.3	0.9	2.9
Worry too long after embarrassment	0.5	0.9	3.1	-1.7	0.5	0.6	0.2	-1.8	0.7	0.2	-0.2	0.7	0.8	1.2	1.0
Medication: Omeprazole	0.5	0.6	5.9	-0.0	-0.8	0.1	-0.2	-0.2	-0.1	-0.2	-0.4	-0.5	-0.4	-0.3	-2.4
Alcohol intake frequency.	0.5	1.1	4.4	1.7	0.4	1.0	0.6	2.1	0.1	0.6	-0.2	0.8	0.5	0.2	2.0
Smoking status: Previous	0.5	0.8	4.2	-0.4	-0.7	-0.5	-0.8	-0.9	-0.8	-0.8	0.2	-0.5	-0.5	-1.1	-2.1
Smoking status: Current	0.5	0.9	4.1	1.2	-0.7	-0.4	-0.1	1.0	-0.9	-0.1	0.3	-0.1	-0.1	-1.6	-2.0
Age started oral contraceptive pill	0.5	0.6	3.3	0.9	-1.0	-0.2	-0.2	-0.0	-1.1	-0.2	0.3	-0.2	-0.2	0.8	-1.8
Ever depressed for a whole week	0.5	0.6	3.6	0.8	-0.8	0.6	0.3	0.6	-0.5	0.4	-0.8	0.0	0.4	1.9	-0.5
Pain experienced in last month	0.5	0.8	7.0	0.3	0.0	-0.8	-0.6	-0.6	-0.5	-0.6	0.5	-0.5	-0.6	2.6	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.2	1.7	0.8	0.9	0.5	1.5	-0.8	0.6	1.8	0.5	0.6	0.9	-0.8
LDL Cholesterol	0.4	0.7	1.4	-0.4	-1.2	-0.8	-0.9	0.0	-1.0	-0.9	-1.0	-0.7	-0.9	-0.9	-0.3
Blood Eosinophil Count	0.4	3.0	13.5	3.7	-0.6	-0.1	-0.9	2.5	-2.6	-0.9	0.3	-0.8	-0.8	1.3	-2.2
Respiratory disease	0.4	1.0	2.3	0.3	0.9	1.4	0.7	1.4	0.2	0.7	1.2	1.5	1.0	-1.0	0.6
Neuroticism	0.4	0.9	4.4	-1.7	-0.8	-0.4	-0.7	-2.1	0.1	-0.7	-0.5	-0.2	-0.6	1.0	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	3.1	-0.6	-0.8	-0.1	0.1	-1.8	0.4	0.1	-0.5	0.3	0.2	-0.6	-0.5
Supplements: Zinc	0.4	0.4	3.5	0.2	0.4	-0.1	-0.2	0.0	0.4	-0.2	-0.7	-0.3	-0.3	0.8	1.9
Pain all over the body in last month	0.4	0.5	1.6	0.1	-0.3	-0.3	-0.6	-0.7	-1.2	-0.5	0.2	-0.1	-0.4	-1.0	1.3
Time employed in main current job	0.4	0.5	2.9	-0.9	-0.1	-0.2	-0.4	0.1	0.2	-0.4	-0.9	0.4	-0.3	-0.8	1.7
Pulse rate	0.4	0.7	3.0	0.0	-0.3	-1.0	-0.9	-0.1	-0.8	-1.0	-0.1	-1.1	-0.9	0.1	-1.7
Glaucoma (self-reported)	0.4	0.5	1.4	-0.4	0.9	1.1	0.3	0.6	0.4	0.3	0.3	1.2	0.4	0.6	0.9
Qualifications: College or University degree	0.4	1.3	6.7	2.1	0.2	-0.2	0.4	1.2	-0.4	0.5	1.1	-0.4	-0.1	1.1	-2.6
Medication for pain relief, constipation, heartburn	0.4	0.7	3.4	-1.2	-0.3	-0.6	-0.5	-1.2	0.2	-0.5	-0.3	-0.2	-0.6	0.5	1.9
Diabetes diagnosed by doctor	0.4	0.7	3.2	1.8	0.6	0.5	0.6	1.4	0.4	0.6	0.2	0.2	0.5	0.4	-1.2
Mineral and other dietary supplements	0.4	0.6	2.9	0.5	-0.3	-1.1	-0.4	-0.2	-0.5	-0.4	1.1	-0.2	-0.8	0.0	-1.7
Osteoporosis (self-reported)	0.4	0.5	5.0	0.4	0.0	0.3	0.1	0.6	-0.0	0.2	-0.1	0.5	0.4	2.2	-0.1
Commuting to job workplace: Public transport	0.4	0.5	3.5	-0.3	0.4	-0.1	0.4	-0.4	0.9	0.3	0.6	-0.3	0.1	0.2	-1.9
Medication: Atorvastatin	0.4	0.5	3.4	1.0	-0.8	-0.5	0.1	-0.3	0.1	0.1	-0.4	-0.6	-0.3	-0.3	-1.8
Number of operations (self-reported)	0.4	0.6	4.6	0.7	-0.7	-0.1	-0.0	-0.8	0.4	-0.0	-0.6	-0.9	-0.0	0.2	-2.2
Myopia	0.4	0.5	1.6	-1.3	-0.2	0.3	0.8	-0.7	0.7	0.7	1.1	0.4	0.6	-0.3	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.7	-0.4	-0.0	0.9	0.6	-0.0	0.6	0.6	0.1	0.3	0.5	-0.4	-1.9
Depressed Affect (Nagel 2018)	0.3	0.5	2.3	-1.3	-0.7	-0.4	-0.3	-1.5	0.1	-0.3	-0.3	-0.0	-0.2	0.8	-0.8
Bipolar Disorder (2011)	0.3	0.3	1.2	0.6	0.1	0.1	0.2	0.5	-0.7	0.2	1.1	0.1	0.2	-0.6	-0.9
Blood Red Count	0.3	3.1	11.1	-1.2	-2.2	-1.3	-1.1	-3.3	-0.3	-1.1	-1.1	-1.8	-1.2	-1.5	-2.7
Hypothyroidism (self reported)	0.3	0.7	2.7	-1.3	0.3	0.4	0.5	-0.8	1.6	0.5	-0.1	0.4	0.3	1.4	0.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.2	1.0	-0.3	-0.5	-0.2	0.9	-0.5	-0.2	-0.3	-0.8	-0.2	-0.7	-1.8
Lung FEV1/FVC ratio	0.3	1.5	6.1	-2.4	-0.8	-0.8	-0.7	-0.7	-0.4	-0.7	-1.4	-0.8	-0.7	-2.5	0.5
Systolic blood pressure, automated reading	0.3	0.8	3.2	-0.8	0.4	0.7	0.9	-0.0	0.4	0.9	1.8	0.6	0.8	-0.7	-1.4
Average weekly fortified wine intake	0.3	0.3	2.8	0.9	0.1	0.3	0.2	0.2	-0.2	0.2	-0.1	0.1	0.1	1.7	-0.3
Maternal smoking around birth	0.3	0.4	1.8	-0.6	-0.6	-0.0	-0.2	1.3	-1.3	-0.2	-0.3	-0.1	0.1	0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	2.5	-1.6	0.3	0.5	0.3	0.2	0.2	0.3	0.2	0.5	0.6	-0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	-0.6	0.6	1.0	0.7	-0.5	0.7	0.7	0.3	1.0	0.9	0.7	0.2
Father’s age at death	0.3	0.4	2.8	-0.7	-0.7	0.3	0.1	-1.7	0.2	0.1	0.1	0.3	0.3	0.3	-0.9
Prospective memory result	0.3	0.4	1.4	-0.9	-0.3	-0.2	-0.1	-1.2	0.8	-0.1	-0.6	-0.7	-0.4	0.5	0.2
Standing height	0.3	3.4	5.8	-2.1	-1.7	-1.5	-2.1	1.6	-2.4	-2.1	-1.4	-1.9	-2.4	-1.5	-0.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.2	0.5	0.4	0.8	0.7	0.7	0.8	0.7	0.5	0.5	0.5	-0.0
Birth weight of first child	0.3	0.5	2.7	0.4	0.0	0.5	-0.1	0.4	-0.3	-0.1	-1.2	0.1	0.2	-0.9	1.7
Peak expiratory flow (PEF)	0.3	0.8	2.0	-1.4	-0.8	-0.9	-0.9	-0.1	-0.2	-0.9	-0.9	-0.9	-1.1	-0.9	-0.8
Headache pain in last month	0.3	0.5	1.8	1.4	0.0	0.3	0.4	1.2	0.2	0.4	-0.8	0.3	0.3	-1.1	0.4
Angina (self-reported)	0.3	0.4	3.2	1.8	-0.0	0.0	0.2	0.0	-0.2	0.2	0.3	0.2	-0.1	1.1	-0.6
Pulse rate, automated reading	0.3	1.0	2.3	-1.0	-1.0	-1.1	-1.1	-0.6	-0.5	-1.1	-1.5	-1.3	-1.2	0.3	0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.3	1.0	0.7	0.4	0.6	0.5	0.4	1.1	0.8	0.4	-0.3	0.2
Average weekly red wine intake	0.3	0.4	2.2	-0.1	0.6	-0.1	0.2	0.2	0.1	0.2	1.5	0.1	0.0	0.9	-1.1
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-1.0	0.6	0.9	0.7	0.3	0.7	0.7	0.3	0.7	0.8	1.0	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	-0.1	-0.2	-0.2	-0.6	0.6	-1.0	-0.5	-0.2	-0.3	-0.4	-0.5	-0.9
Eye problems/disorders: Glaucoma	0.3	0.4	1.7	0.5	0.9	0.9	0.2	1.3	0.1	0.2	0.2	1.0	0.2	-0.1	0.4
High cholesterol (Self-reported)	0.3	0.4	2.2	0.8	0.3	0.2	0.1	0.6	-0.6	0.2	1.2	0.3	0.3	0.1	-1.5
Alcohol drinker status: Never	0.3	0.3	0.7	0.8	0.1	0.4	0.8	-0.0	0.7	0.8	0.5	0.5	0.6	0.5	0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.8	-0.7	0.5	0.4	0.1	-0.7	0.9	0.1	0.0	0.2	0.0	0.3	-0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.7	0.4	1.0	0.4	1.0	-1.1	0.4	0.5	0.3	0.6	0.0	0.8
Ovarian Cancer	0.2	0.3	0.9	0.6	0.2	0.3	0.3	0.0	0.8	0.3	-0.8	0.1	0.1	0.9	0.9
Blood Platelet Count	0.2	2.3	9.4	1.7	1.4	0.9	1.2	1.7	1.1	1.2	3.1	1.8	0.8	1.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.6	-0.1	0.8	0.5	0.6	-0.3	0.5	0.5	0.7	0.7	0.1	-0.3
Diabetes (mother)	0.2	0.3	2.0	1.1	-0.3	-0.1	0.2	0.1	0.4	0.2	-0.2	0.1	-0.2	-0.4	-1.4
Pack years adult smoking proportion	0.2	0.3	1.0	0.5	0.1	-0.1	-0.4	-1.0	-0.2	-0.4	-0.3	-0.7	-0.3	0.9	0.3
Multivitamins +/- minerals	0.2	0.2	1.3	0.3	0.0	0.1	-0.2	0.9	-0.2	-0.2	-0.6	0.0	0.0	-0.4	1.1
Alcohol usually taken with meals	0.2	0.3	1.0	0.2	-1.0	-0.6	-0.3	-0.2	-0.2	-0.3	-0.7	-0.8	-0.5	-0.3	-0.1
Financial difficulties in last 2 years	0.2	0.2	1.3	0.3	0.3	-0.6	-0.3	0.2	-0.2	-0.3	0.7	-0.3	-0.2	0.5	-1.1
Noisy workplace	0.2	0.2	1.2	1.1	-0.0	0.2	0.3	0.6	-0.2	0.3	0.0	0.3	0.3	-0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.9	-0.1	-0.8	-0.3	-0.3	0.0	-0.9	-0.3	0.0	0.1	0.0	-0.9	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.3	0.4	1.0	0.9	0.1	1.1	0.9	-0.7	0.6	0.8	0.8	-0.0
Loud music exposure frequency	0.2	0.2	1.2	-0.6	0.2	0.3	-0.0	-0.5	0.2	-0.0	0.2	-0.1	-0.1	-1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	-1.1	0.6	0.4	-0.0	0.3	-0.3	0.0	0.8	0.8	0.4	0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	-1.0	-0.5	-0.3	-0.2	-1.0	0.4	-0.2	-0.7	-0.5	-0.4	0.7	-0.5
High blood pressure (siblings)	0.2	0.3	1.6	-0.0	0.7	0.6	-0.0	-0.1	-0.4	-0.0	1.2	0.7	0.2	-0.5	0.3
Neck or shoulder pain in last month	0.2	0.2	1.9	0.1	-0.4	-0.1	-0.1	-0.7	-0.1	-0.1	-0.3	-0.2	-0.1	-1.4	-0.1
Medication: Ibuprofen	0.2	0.3	0.9	0.5	0.7	0.2	0.5	0.9	0.1	0.5	0.5	0.4	0.4	0.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.7	-0.5	-0.2	0.1	-0.8	0.5	0.1	-0.8	-0.2	0.3	-0.9	-0.3
Knee pain experienced in last month	0.2	0.3	0.6	0.6	0.5	0.6	0.6	0.4	0.6	0.6	-0.4	0.5	0.7	-0.4	0.8
Illnesses of father: Heart disease	0.2	0.2	1.3	1.1	0.4	0.1	0.1	0.2	0.0	0.2	0.8	-0.2	0.2	-0.7	-0.4
Mood swings	0.2	0.3	0.8	-0.3	0.0	0.4	0.4	-0.8	0.8	0.4	0.0	0.9	0.6	0.8	-0.1
Breast cancer (self-reported)	0.2	0.3	1.6	-0.1	-0.2	-0.1	0.3	-1.3	0.8	0.3	0.4	-0.4	0.2	-0.4	-0.2
Medication: Lisinopril	0.2	0.2	2.0	-0.5	0.2	-0.2	0.1	-0.6	0.4	0.1	0.2	-0.2	-0.1	-1.4	-0.0
Irritability	0.2	0.4	1.5	-0.7	-0.6	0.1	-0.3	-1.0	0.4	-0.3	-1.2	-0.3	-0.1	0.5	-0.8
Diastolic blood pressure, automated reading	0.2	0.5	2.4	-0.3	0.8	0.4	0.6	0.6	0.0	0.6	1.5	0.2	0.6	-0.7	-0.9
Pack years of smoking	0.2	0.3	1.8	0.5	0.4	0.2	-0.2	-0.9	0.0	-0.2	-0.0	-0.5	-0.0	1.4	0.5
Depression (Nagel 2018)	0.1	0.1	0.4	-0.6	-0.3	-0.1	-0.2	-0.1	-0.5	-0.2	-0.3	-0.2	-0.1	0.3	0.3
Reaction Time	0.1	0.2	0.7	0.8	-0.5	-0.4	-0.4	-0.6	-0.6	-0.4	-0.1	-0.2	-0.2	-0.7	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.9	0.9	-0.1	0.2	0.3	0.0	0.2	0.3	0.2	0.3	0.4	0.6	-0.7
Height	0.1	2.6	9.7	-1.7	-0.9	-1.0	-1.5	3.1	-2.6	-1.5	-0.4	-1.3	-1.8	-0.0	-0.9
Waist Hip Ratio (WHR)	0.1	0.5	2.9	-0.4	0.9	0.2	0.4	1.2	-0.1	0.4	0.4	0.5	0.5	-0.5	1.7
Hair Pigment	0.1	4.2	11.6	1.8	3.0	1.6	1.5	2.4	0.8	1.5	2.5	1.4	1.6	1.3	3.4
Vitamin and mineral supplements	0.1	0.2	0.8	-0.4	-0.5	-0.3	-0.1	-0.7	-0.3	-0.1	-0.1	-0.3	-0.3	-0.2	-0.9
Taking other prescription medications	0.1	0.1	0.3	0.2	-0.2	0.2	-0.2	0.5	-0.5	-0.2	-0.2	-0.1	-0.1	0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.3	-0.4	-0.0	-0.1	-0.4	-0.4	-0.1	0.4	-0.3	-0.1	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.4	-0.1	-0.5	-0.3	-0.2	0.0	-0.3	0.4	-0.1	-0.7	-0.6	-0.4
Illnesses of siblings	0.1	0.1	0.6	-0.3	-0.2	-0.5	0.2	0.2	0.3	0.2	-0.8	-0.2	-0.1	-0.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	1.0	0.4	0.4	0.1	0.3	1.0	-0.0	0.3	0.5	0.4	0.1	-0.2	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.6	0.7	-0.1	-0.1	-0.5	-0.7	0.1	-0.5	-0.4	-0.2	-0.6	0.2	-0.3
Mean time to correctly identify matches	0.1	0.2	0.7	0.8	-0.4	-0.4	-0.4	-0.5	-0.4	-0.4	-0.4	-0.3	-0.3	-0.7	-0.2
Comparative height size at age 10	0.1	0.5	3.6	-0.8	0.9	0.4	-0.3	1.9	-0.3	-0.3	0.8	-0.3	-0.4	-0.1	-0.1
Had major operations	0.1	0.1	0.7	-0.3	0.1	0.1	0.0	0.2	0.5	0.0	-0.9	-0.2	0.2	0.7	0.2
Guilty feelings	0.1	0.1	0.5	0.4	-0.1	0.2	-0.2	0.0	-0.7	-0.2	0.5	0.4	0.1	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.9	0.9	0.1	0.1	-0.2	-0.7	0.3	-0.2	-0.2	0.1	-0.4	0.6	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.3	2.5	0.5	0.6	-0.0	0.1	-0.5	0.3	0.1	0.4	0.1	0.1	0.2	-1.6
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.2	-0.4	-0.1	-0.2	0.2	-0.2	0.4	0.2	0.1	0.1	-0.1	0.1	-0.4

Hub : Genes

WNK1

Models

Trait associations