Best TWAS P=7.93e-17 · Best GWAS P=1.09e-17 conditioned to 1.9e-28
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ZNF740 | 0.12 | 0.07 | enet | 18 | 0.09 | 7.1e-08 | -3.2 | -5.3 | 1.2e-07 | 0.03 | 0.93 | 0.01 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | ATP5G2 | 0.26 | 0.26 | lasso | 6 | 0.21 | 1.0e-05 | -6.4 | -6.0 | 1.6e-09 | 0.07 | 0.31 | 0.04 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | RP11-793H13.3 | 0.29 | -0.01 | enet | 49 | 0.02 | 1.0e-01 | -3.7 | -5.8 | 7.5e-09 | -0.01 | 0.05 | 0.06 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PFDN5 | 0.19 | 0.14 | lasso | 5 | 0.16 | 7.8e-12 | 7.3 | 7.2 | 6.2e-13 | -0.08 | 0.84 | 0.16 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-680A11.5 | 0.10 | 0.03 | lasso | 4 | 0.03 | 1.3e-03 | -3.1 | 6.0 | 1.8e-09 | -0.08 | 0.19 | 0.52 | FALSE |
| 6 | GTEx | Heart Left Ventricle | RP11-793H13.11 | 0.12 | 0.00 | enet | 17 | 0.05 | 1.6e-03 | -4.6 | 5.8 | 5.6e-09 | -0.06 | 0.06 | 0.78 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP11-793H13.11 | 0.05 | 0.03 | lasso | 6 | 0.02 | 6.1e-03 | 7.5 | 7.0 | 3.6e-12 | -0.08 | 0.40 | 0.42 | FALSE |
| 8 | GTEx | Whole Blood | HNRNPA1 | 0.10 | 0.00 | enet | 24 | 0.00 | 1.1e-01 | 1.4 | -6.5 | 5.9e-11 | -0.04 | 0.06 | 0.05 | TRUE |
| 9 | YFS | Blood | MFSD5 | 0.13 | 0.07 | enet | 17 | 0.10 | 1.2e-30 | 5.2 | -5.8 | 9.0e-09 | 0.14 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ATP5G2 | 0.06 | 0.04 | lasso | 6 | 0.06 | 7.1e-06 | 4.6 | -5.4 | 5.9e-08 | 0.13 | 0.40 | 0.24 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HOTAIR | 0.07 | 0.06 | enet | 4 | 0.05 | 8.9e-05 | -5.8 | -6.1 | 1.2e-09 | 0.06 | 0.85 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MFSD5 | 0.02 | 0.01 | blup | 37 | 0.01 | 4.3e-03 | 5.2 | -6.3 | 2.9e-10 | 0.08 | 0.02 | 0.12 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATP5G2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 4.0e-04 | -6.4 | -6.3 | 2.7e-10 | 0.06 | 0.14 | 0.67 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ESPL1 | 0.05 | 0.08 | lasso | 2 | 0.07 | 5.5e-08 | 7.3 | -7.2 | 5.9e-13 | 0.05 | 0.12 | 0.88 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOTAIR | 0.08 | 0.13 | enet | 12 | 0.13 | 1.1e-14 | -6.2 | -5.7 | 9.3e-09 | 0.04 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ESPL1 | 0.10 | 0.12 | blup | 43 | 0.13 | 1.6e-06 | 6.7 | -7.2 | 5.0e-13 | 0.08 | 0.15 | 0.84 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOTAIR | 0.10 | 0.12 | lasso | 3 | 0.11 | 1.8e-11 | -6.3 | -7.0 | 1.9e-12 | 0.11 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HOXC11 | 0.09 | 0.04 | lasso | 2 | 0.03 | 9.3e-04 | 7.6 | -7.7 | 9.8e-15 | 0.31 | 0.24 | 0.15 | TRUE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MFSD5 | 0.07 | 0.05 | lasso | 2 | 0.05 | 3.8e-06 | 5.3 | -5.5 | 4.2e-08 | 0.11 | 0.84 | 0.02 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | HOXC10 | 0.33 | 0.02 | blup | 56 | 0.06 | 8.2e-03 | -7.7 | 8.3 | 7.9e-17 | -0.55 | 0.00 | 0.56 | TRUE |
| 21 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | HOXC11 | 0.30 | 0.00 | blup | 57 | 0.10 | 1.1e-03 | -7.7 | 7.4 | 1.1e-13 | -0.64 | 0.00 | 0.52 | TRUE |