TWAS hub - ESPL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0494	0.0203	1.9e-07	0.077	0.064	0.061	NA	0.067	5.0e-09	1.1e-07	2.2e-07	NA	5.5e-08
2	TCGA	Liver Hepatocellular Carcinoma	0.0960	0.0450	1.1e-05	0.115	0.126	0.121	NA	0.107	4.6e-06	1.6e-06	2.6e-06	NA	1.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Osteoporosis (self-reported)	20.1	24.9	28.0	4.7	5.3
High blood pressure (mother)	12.9	18.1	20.0	4.0	4.5
Heel bone mineral density (BMD) T-score, automated (left)	12.6	28.5	30.4	-5.5	-5.2
Heel bone mineral density (BMD) T-score, automated (right)	10.9	25.0	26.2	-5.1	-4.9
Supplements: Calcium	7.5	8.2	8.6	2.8	2.9
Basal cell carcinoma (self-reported)	6.6	7.8	8.4	-2.7	-2.9
Heel T-Score	6.5	52.1	52.3	-7.2	-7.2
Pulse wave peak to peak time	6.1	7.2	8.2	-2.5	-2.9
Illnesses of mother	5.8	7.2	8.3	-2.5	-2.9
Pulse wave Arterial Stiffness index	5.5	6.5	7.6	2.3	2.8
Risk taking	5.0	7.4	7.7	2.7	2.8
Diverticular disease/diverticulitis (self-reported)	4.6	5.5	6.6	2.1	2.6
Fractured/broken bones in last 5 years	4.2	5.4	6.1	2.2	2.5
Blood Red Count	4.1	39.4	49.8	7.1	5.4
Diabetes (mother)	4.0	5.2	5.2	2.3	2.3
Eye problems/disorders: Glaucoma	3.6	4.2	4.5	-2.1	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	3.5	3.8	4.2	1.8	2.1
Heart disease (mother)	3.3	4.1	6.2	1.4	2.5
Illness, injury, bereavement, stress in last 2 years	3.3	4.1	4.6	-1.9	-2.1
Qualifications: None of the above	3.2	6.9	8.4	-2.9	-2.3
Pulse rate	3.0	5.1	6.5	2.5	1.9
Medication: Lansoprazole	2.9	3.3	3.6	1.9	1.7
Handedness (chirality/laterality): Left-handed	2.9	3.5	3.6	1.9	1.9
Age at first live birth	2.7	4.9	6.1	-2.5	-1.9
Myopia	2.7	3.9	4.8	1.7	2.2
Had other major operations	2.6	3.2	4.0	1.5	2.0
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	4.4	2.1	2.0
Eye problems/disorders: None of the above	2.6	3.0	3.1	1.7	1.8
Hypothyroidism (self reported)	2.5	5.7	6.0	2.4	2.4
Ever highly irritable/argumentative for 2 days	2.3	2.7	3.2	1.5	1.8
Glaucoma (self-reported)	2.3	2.7	3.4	-1.9	-1.4
Neck or shoulder pain in last month	2.3	3.2	3.3	1.8	1.8
Taking other prescription medications	2.2	3.4	4.5	2.1	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	4.0	1.7	2.0
Medication: Ibuprofen	2.2	2.7	3.8	-1.2	-2.0
Chronic bronchitis/emphysema (mother)	2.1	2.5	2.8	-1.7	-1.5
Schizophrenia (2018)	2.0	4.1	5.3	1.7	2.3
Diabetes (father)	2.0	2.5	2.7	-1.6	-1.5
Headache pain in last month	2.0	3.5	4.1	2.0	1.7
Osteoarthritis (self-reported)	2.0	2.6	2.9	-1.7	-1.5
Financial difficulties in last 2 years	1.9	2.6	2.7	1.6	1.6
Alcohol drinker status: Never	1.9	2.2	2.8	-1.3	-1.7
Schizophrenia (2014)	1.8	3.9	5.3	1.6	2.3
Medication: Simvastatin	1.8	2.6	2.7	1.6	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.6	-1.0	-1.9
Gout (self-reported)	1.8	2.5	2.6	-1.6	-1.5
Alcohol intake versus 10 years previously	1.7	2.5	2.8	1.7	1.5
Mouth/teeth dental problems: Dentures	1.7	2.9	3.5	1.5	1.9
Age started oral contraceptive pill	1.7	2.1	2.3	-1.5	-1.4
Birth weight of first child	1.6	3.0	3.5	-1.6	-1.9
Breast cancer (self-reported)	1.6	1.9	2.8	1.0	1.7
Heart disease (siblings)	1.6	2.0	2.6	1.2	1.6
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	2.6	-1.2	-1.6
Friendships satisfaction	1.5	1.9	2.3	1.2	1.5
Pain type(s) experienced in last month: Hip pain	1.5	1.8	2.8	-0.9	-1.7
Father’s age at death	1.4	1.9	2.2	1.5	1.3
Suffer from ‘nerves’	1.4	2.2	2.3	-1.5	-1.5
Ever had bowel cancer screening	1.4	1.6	2.3	-1.5	-1.0
Medication: Atorvastatin	1.4	1.7	1.8	1.3	1.3
Crohns Disease (2017)	1.3	2.8	2.9	1.7	1.6
Ovarian Cancer	1.3	1.8	2.2	1.5	1.2
Crohns Disease (2012)	1.3	2.2	2.9	1.7	1.2
Asthma	1.3	2.6	3.0	-1.5	-1.7
Knee pain experienced in last month	1.3	2.0	2.3	-1.5	-1.3
Asthma (self-reported)	1.3	2.7	3.0	-1.5	-1.7
Age at First Birth	1.2	1.8	2.3	-1.5	-1.1
Triglycerides	1.2	2.0	2.2	1.4	1.5
Supplements: Zinc	1.2	1.3	1.3	1.2	1.1
Stomach or abdominal pain in last month	1.2	1.4	2.2	0.8	1.5
Time employed in main current job	1.1	1.3	1.4	-1.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.6	1.6	0.9
Comparative body size at age 10	1.1	3.1	4.5	-1.3	-2.1
Miserableness	1.1	1.9	2.4	1.2	1.6
Mother’s age at death	1.1	1.3	1.6	-1.0	-1.2
Commuting to job workplace: Cycle	1.1	1.4	2.4	-1.6	-0.5
Coronary Artery Disease (CAD)	1.0	1.2	1.3	-1.1	-1.1
Allergy or Eczema	1.0	2.7	3.0	1.6	1.7
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.4	-1.0	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	1.7	-1.3	-0.8
Eye problems/disorders: Cataract	1.0	1.2	1.4	-1.2	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.2	1.4	-1.0	-1.2
Average weekly champagne plus white wine intake	1.0	1.4	1.5	1.2	1.2
Commuting to job workplace: Public transport	1.0	1.2	1.5	1.0	1.2
Medication: Lisinopril	1.0	1.3	1.8	1.0	1.3
HDL Cholesterol	0.9	1.5	2.0	-1.4	-1.0
Rheumatoid Arthritis	0.9	1.3	1.6	1.0	1.2
Number of incorrect matches in round	0.9	1.5	2.3	-1.5	-0.8
Happiness	0.9	1.2	2.1	-1.5	-0.4
Worry too long after embarrassment	0.9	1.6	2.0	-1.4	-1.1
Medication: Omeprazole	0.9	1.1	1.3	1.1	1.0
Arm predicted mass (right)	0.9	4.7	8.0	-1.2	-2.8
Pulse rate, automated reading	0.9	2.9	4.2	2.0	1.3
Number of full sisters	0.9	1.1	1.9	-1.4	-0.5
Age at last live birth	0.9	1.4	1.7	-1.3	-1.0
Commuting to job workplace: Walk	0.9	1.0	1.2	0.9	1.1
Medication for cholesterol	0.9	1.4	1.4	-1.2	-1.2
High cholesterol (Self-reported)	0.9	1.6	1.7	1.2	1.3
Diastolic blood pressure, automated reading	0.9	2.9	3.0	1.7	1.6
Ever depressed for a whole week	0.9	1.1	1.2	-1.0	-1.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.5	-0.6	-2.1
Primary Biliary Cirrhosis	0.8	1.1	1.6	0.9	1.2
Cardiovascular Disease	0.8	2.7	3.2	1.8	1.5
Hearing difficulty/problems: Yes	0.8	1.2	1.5	-0.9	-1.2
Qualifications: CSEs or equivalent	0.8	1.0	1.4	1.2	0.9
Pulse wave reflection index	0.8	0.9	1.1	0.9	1.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.1	-1.1	-0.9
Chest pain or discomfort	0.8	1.1	1.2	1.0	1.1
Qualifications: nursing, teaching	0.8	1.2	1.3	1.0	1.2
Number of operations (self-reported)	0.8	1.3	1.7	1.3	0.9
Irritability	0.8	1.4	1.8	1.0	1.3
Bipolar Disorder or Schizophrenia	0.7	1.8	2.6	1.0	1.6
Depression (Nagel 2018)	0.7	1.0	1.1	1.0	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	0.9	-0.8	-1.0
Blood White Count	0.7	5.3	5.8	2.4	2.2
Medication: Ramipril	0.7	0.9	1.3	0.7	1.2
Loud music exposure frequency	0.7	0.8	0.9	-1.0	-0.8
High blood pressure (siblings)	0.7	1.0	1.1	0.9	1.0
Arm fat-free mass (right)	0.7	3.3	5.8	-0.9	-2.4
Qualifications: College or University degree	0.7	2.3	2.7	1.4	1.6
Medication for pain relief, constipation, heartburn	0.7	1.3	2.5	0.1	1.6
Supplements: Vitamin C	0.7	0.8	1.1	0.7	1.0
Loneliness, isolation	0.7	1.0	1.2	0.9	1.1
Alcohol drinker status: Previous	0.7	0.8	0.9	0.8	1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	0.9	0.9	1.0
Major Depression (MDD)	0.6	0.8	0.8	0.9	0.9
Reaction Time	0.6	1.2	1.3	1.1	1.2
Mean Putamen Volume	0.6	0.7	1.1	-0.5	-1.1
Neuroticism (2016)	0.6	0.9	0.9	-0.9	-0.9
Hand grip strength (left)	0.6	1.6	1.9	1.4	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	0.9	0.8	0.9
Pack years adult smoking proportion	0.6	1.0	1.3	-0.8	-1.1
Maternal smoking around birth	0.6	0.9	1.5	0.5	1.2
Weight	0.6	2.9	5.2	-0.7	-2.3
Impedance of arm (right)	0.6	2.7	4.7	0.9	2.2
Hip circumference	0.6	2.4	4.2	-0.8	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	0.8	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.2	1.0	1.1
Number of children fathered	0.6	0.6	1.2	-1.1	-0.2
Had major operations	0.6	0.7	1.2	1.1	0.5
Wears glasses or contact lenses	0.6	0.7	0.8	-0.7	-0.9
Alzheimer’s Disease (in father)	0.5	0.6	0.7	-0.7	-0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.1	-0.3	-1.5
Number of treatments/medications taken	0.5	0.9	1.2	1.1	0.7
Average weekly spirits intake	0.5	0.7	0.8	-0.7	-0.9
Multivitamins +/- minerals	0.5	0.7	0.8	0.7	0.9
Medication: Levothyroxine sodium	0.5	0.9	1.0	0.9	1.0
Body mass index (BMI)	0.5	2.1	4.0	-0.4	-2.0
Waist circumference	0.5	1.7	2.9	-0.8	-1.7
Hair/balding pattern: Pattern 2	0.5	0.6	0.6	0.8	0.8
Pain all over the body in last month	0.5	0.5	0.5	-0.7	-0.7
Worrier / anxious feelings	0.5	0.9	1.2	0.8	1.1
Breastfed as a baby	0.5	0.6	1.1	1.0	0.3
Blood clot in the leg (DVT)	0.5	0.6	0.7	0.8	0.7
Mean time to correctly identify matches	0.5	1.0	1.4	0.8	1.2
Diabetes diagnosed by doctor	0.5	0.9	1.0	-1.0	-0.8
Illnesses of father: High blood pressure	0.5	0.6	1.0	0.5	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	0.8	0.9	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.6	0.8	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	0.9	0.8	1.0
Bipolar Disorder (2011)	0.4	0.4	0.7	0.8	0.2
Respiratory disease	0.4	0.9	1.0	-1.0	-0.9
Hand grip strength (right)	0.4	1.2	1.6	1.2	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	0.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.5	-0.6	-0.7
Sitting height	0.4	3.0	4.7	-1.2	-2.2
Falls in the last year	0.4	0.6	1.1	-1.0	-0.2
Number of live births	0.4	0.6	0.6	0.7	0.8
Tense / ‘highly strung’	0.4	0.7	1.3	0.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.3	-0.3	-1.1
Medication: Allopurinol	0.4	0.5	0.6	-0.7	-0.8
Whole body fat mass	0.4	1.5	2.7	-0.5	-1.6
Leg fat mass (right)	0.4	1.4	2.5	-0.5	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.2	-0.9
Illnesses of father: Heart disease	0.4	0.5	0.9	0.9	0.5
Smoking status: Previous	0.4	0.5	0.7	0.6	0.8
Leg fat-free mass (right)	0.4	1.9	3.8	-0.0	-1.9
Medication: Gliclazide	0.4	0.4	0.5	0.7	0.6
Leg predicted mass (right)	0.4	2.0	3.9	-0.0	-2.0
Medication: Bendroflumethiazide	0.4	0.6	0.7	0.8	0.8
Ever smoked	0.4	0.6	0.7	0.8	0.8
Basal metabolic rate	0.4	2.0	3.9	-0.3	-2.0
Arm fat-free mass (left)	0.4	1.8	3.5	-0.3	-1.9
Cholesterol lowering medication	0.4	0.7	0.9	0.9	0.7
Pack years of smoking	0.4	0.6	0.8	-0.6	-0.9
Leg fat mass (left)	0.4	1.5	2.7	-0.5	-1.6
Arm predicted mass (left)	0.4	1.8	3.5	-0.3	-1.9
Ulcerative Colitis (UC)	0.3	0.7	0.7	-0.8	-0.8
LDL Cholesterol	0.3	0.5	0.7	0.9	0.5
Blood Platelet Count	0.3	3.2	4.4	2.1	1.4
Systolic Blood Pressure	0.3	1.4	2.1	0.9	1.4
Neuroticism	0.3	0.7	1.4	0.3	1.2
Tanning	0.3	3.9	4.1	-2.0	-1.9
Ever had hysterectomy (womb removed)	0.3	0.4	0.5	-0.5	-0.7
Systolic blood pressure, automated reading	0.3	0.8	1.4	0.4	1.2
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.7	-0.1
Leg fat-free mass (left)	0.3	1.8	3.5	-0.0	-1.9
Trunk fat percentage	0.3	1.2	2.0	-0.5	-1.4
Current tobacco smoking	0.3	0.4	0.6	-0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.3	-0.6	-0.6
Supplements: Glucosamine	0.3	0.4	0.4	-0.6	-0.6
Leg predicted mass (left)	0.3	1.8	3.7	-0.0	-1.9
Trunk fat mass	0.3	1.5	2.7	-0.5	-1.6
Had menopause	0.3	0.3	0.5	0.3	0.7
Illnesses of siblings	0.3	0.4	0.6	-0.4	-0.8
Body fat percentage	0.3	1.0	1.8	-0.5	-1.3
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.4	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.6	-0.8	-0.7
Whole body fat-free mass	0.3	1.7	3.3	-0.2	-1.8
Medication: Aspirin	0.3	0.4	0.8	0.9	0.2
Smoking status: Current	0.3	0.5	0.8	-0.9	-0.5
Whole body water mass	0.3	1.5	3.0	-0.1	-1.7
Arm fat mass (left)	0.3	1.2	2.4	-0.2	-1.6
Financial situation satisfaction	0.3	0.4	0.7	-0.8	-0.4
Medication: Blood pressure	0.3	0.6	0.8	0.7	0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.5	-0.8
Pain experienced in last month	0.3	0.4	0.8	-0.9	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.7	0.2
HbA1C	0.2	0.3	0.4	-0.3	-0.7
Ulcerative Colitis	0.2	0.3	0.4	-0.3	-0.7
BMI	0.2	1.3	2.4	0.4	-1.6
Waist Hip Ratio (WHR)	0.2	0.8	1.5	0.4	1.2
Lung FVC	0.2	1.2	2.0	-1.4	-0.6
Hair Pigment	0.2	4.7	5.8	1.9	2.4
Medication: Co-codamol	0.2	0.2	0.4	-0.6	-0.3
Impedance of leg (right)	0.2	0.9	1.3	-0.6	1.2
High blood pressure	0.2	0.5	0.5	0.7	0.7
Impedance of leg (left)	0.2	0.8	1.1	-1.1	0.7
Past tobacco smoking	0.2	0.4	0.5	-0.4	-0.7
Nervous feelings	0.2	0.3	0.5	-0.7	-0.4
Allergy	0.2	0.5	0.7	0.5	0.8
Fluid intelligence score	0.2	0.3	0.6	0.2	-0.8
Trunk fat-free mass	0.2	1.1	2.2	-0.1	-1.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	0.8	0.6
Medication: Cholesterol lowering	0.2	0.4	0.4	0.6	0.6
Depression (self-reported)	0.2	0.2	0.3	0.5	0.4
Prospective memory result	0.2	0.2	0.3	0.2	0.6
Arm fat mass (right)	0.2	0.6	1.3	0.2	-1.1
Trunk predicted mass	0.2	1.1	2.2	-0.1	-1.5
Length of working week for main job	0.2	0.2	0.3	0.5	0.5
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.1	1.1	0.2
Medication: Paracetamol	0.2	0.4	0.7	-0.0	-0.8
Medication: Amlodipine	0.2	0.3	0.3	0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.2	0.5	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.3	-0.7
Medication: Blood pressure	0.2	0.3	0.4	-0.4	-0.6
Leg pain on walking	0.2	0.3	0.6	-0.2	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.4	0.5
Back pain experienced in last month	0.2	0.4	0.5	-0.5	-0.7
Guilty feelings	0.2	0.3	0.5	-0.7	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.5	-0.5
Hearing aid user	0.2	0.2	0.2	-0.4	-0.4
Leg fat percentage (left)	0.2	0.7	1.2	-0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.4	-0.6	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.6	0.2
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.5	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.4	0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.3	0.6	0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	-0.0
Fasting Glucose	0.1	0.2	0.2	-0.4	0.4
Blood Eosinophil Count	0.1	0.9	1.0	1.0	0.9
Height	0.1	2.1	2.4	-1.4	-1.5
Smoking Status	0.1	0.2	0.3	-0.2	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.3	0.5	-0.6
Chronotype (morning person)	0.1	0.2	0.3	0.5	0.4
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.2	0.6
Relative age of first facial hair	0.1	0.3	0.5	-0.7	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.4	0.1
Angina	0.1	0.1	0.1	-0.3	-0.3
Medication: Metformin	0.1	0.1	0.1	-0.1	-0.4
Severe depression (siblings)	0.1	0.1	0.3	-0.0	0.5
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.1	0.5
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.0	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.3	0.5	0.5
Medication: Atenolol	0.1	0.1	0.2	-0.1	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.3	-0.4
Forced vital capacity (FVC)	0.1	0.2	0.3	-0.5	-0.5
Heart attack	0.1	0.1	0.1	0.2	-0.3
Diabetes (self-reported)	0.1	0.2	0.2	-0.4	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.5	0.1
Neuroticism score	0.1	0.1	0.3	-0.1	0.5
Arm fat percentage (right)	0.1	0.2	0.2	0.5	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.3	-0.7
Noisy workplace	0.1	0.2	0.3	-0.6	0.1
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	0.4	0.4
Impedance of arm (left)	0.1	0.5	1.1	-0.1	1.0
Standing height	0.1	0.7	0.8	-0.7	-0.9
Peak expiratory flow (PEF)	0.1	0.2	0.3	0.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.1	-0.4	-0.2
Birth weight	0.1	0.2	0.3	-0.0	-0.6
Leg fat percentage (right)	0.1	0.4	0.8	-0.2	-0.9
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.1	-0.6
Number of full brothers	0.1	0.1	0.2	-0.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.1	0.5
Health satisfaction	0.1	0.1	0.2	0.4	0.1
Comparative height size at age 10	0.1	0.7	0.7	-0.8	-0.8
Overall health rating	0.1	0.3	0.5	-0.3	-0.7
Family relationship satisfaction	0.1	0.2	0.3	-0.6	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.4	0.2
Medication: Aspirin	0.1	0.1	0.1	0.3	-0.3
Hypertension (Self-reported)	0.1	0.2	0.3	0.5	0.5
Arm fat percentage (left)	0.1	0.6	1.1	-0.0	-1.1
Mood swings	0.1	0.2	0.3	0.5	0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.2	0.5	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	-0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.5	-0.2
Medication: Paracetamol	0.1	0.1	0.3	0.0	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.1	0.4
Impedance of whole body	0.1	0.6	0.7	-0.7	0.8
Worry (Nagel 2018)	0.0	0.1	0.1	-0.1	0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.1	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Lupus	0.0	0.0	0.0	-0.2	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.0	-0.0
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	-0.1
Fed-up feelings	0.0	0.1	0.1	0.1	0.3
Relative age voice broke	0.0	0.1	0.1	-0.2	-0.3
Age when periods started (menarche)	0.0	0.1	0.1	-0.3	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.1	0.3
Alcohol usually taken with meals	0.0	0.0	0.0	0.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.0	-0.0
Mouth/teeth dental problems	0.0	0.0	0.1	0.0	-0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.0	-0.1	0.1
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.1	-0.0
Angina (self-reported)	0.0	0.1	0.1	-0.2	-0.3
Migraine (self-reported)	0.0	0.1	0.1	0.0	-0.3
Alcohol intake frequency.	0.0	0.0	0.0	0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.1	-0.2
Average weekly red wine intake	0.0	0.0	0.1	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.4	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.2	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	0.2	0.1
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.2	0.2
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.3	0.2

Hub : Genes

ESPL1

Models

Trait associations