TWAS hub - PFDN5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1950	0.0490	3.4e-09	0.143	NA	0.135	NA	0.157	7.7e-11	NA	2.4e-10	NA	7.8e-12
2	NTR	Blood	0.0235	0.0088	1.1e-03	0.005	0.008	0.002	0.008	0.003	7.3e-03	0.0010	8.5e-02	0.00067	2.7e-02
3	YFS	Blood	0.0232	0.0098	3.5e-03	0.007	0.006	0.005	0.007	0.006	1.4e-03	0.0037	5.2e-03	0.00200	3.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Osteoporosis (self-reported)	8.2	10.1	22.5	-4.7	-1.9	-2.0
High blood pressure (mother)	6.0	8.4	16.3	-4.0	-2.3	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	5.8	13.3	27.4	5.2	3.1	1.7
Heel bone mineral density (BMD) T-score, automated (right)	5.7	13.1	22.7	4.8	3.4	2.3
Pulse wave peak to peak time	5.1	6.0	8.9	2.4	3.0	1.8
Pulse wave Arterial Stiffness index	5.0	5.8	8.7	-2.4	-3.0	-1.8
Risk taking	4.2	6.2	12.2	-2.2	-3.5	-1.2
Diabetes (mother)	3.7	4.7	6.8	-2.5	-2.6	-1.1
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	4.6	-2.1	-2.1	-1.8
Supplements: Calcium	3.5	3.8	10.2	-3.2	-1.1	-0.2
Illnesses of mother	3.3	4.1	6.6	2.6	2.2	0.9
Pulse wave reflection index	3.3	4.1	12.2	-0.4	-3.5	0.1
Medication: Simvastatin	3.2	4.6	6.8	-1.8	2.6	-2.0
Blood Red Count	3.0	29.4	57.6	-7.6	2.5	-4.9
Chest pain or discomfort	3.0	4.3	7.8	-1.0	-2.0	-2.8
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	9.4	0.5	-3.1	2.1
Heel T-Score	2.8	22.3	51.8	7.2	3.5	1.7
Medication: Aspirin	2.8	3.6	8.1	-0.8	2.8	-1.4
Average weekly beer plus cider intake	2.8	4.1	10.8	0.3	-3.3	-1.2
Age at first live birth	2.7	4.9	7.5	2.7	2.0	1.7
Taking other prescription medications	2.5	3.9	6.0	-2.4	0.0	-2.4
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	8.2	-1.8	0.8	-2.9
Medication: Lansoprazole	2.5	2.8	5.3	-1.7	-2.3	-0.6
Fractured/broken bones in last 5 years	2.5	3.2	5.6	-2.4	-2.0	-0.4
Alcohol intake versus 10 years previously	2.4	3.6	6.6	-1.7	-1.1	-2.6
Had menopause	2.3	2.9	4.4	-1.1	-1.8	2.1
Pulse rate	2.3	3.9	6.2	-2.5	1.1	-2.0
Neck or shoulder pain in last month	2.3	3.3	4.7	-1.9	-1.2	-2.2
Basal cell carcinoma (self-reported)	2.3	2.7	7.9	2.8	0.5	0.2
Had major operations	2.2	2.5	4.0	-0.8	1.7	-2.0
Commuting to job workplace: Walk	2.1	2.3	5.2	-1.3	0.3	-2.3
Alcohol drinker status: Never	2.1	2.5	6.2	1.0	2.5	0.7
Cardiovascular Disease	2.0	6.5	15.3	-1.7	1.0	-3.9
Lung FVC	2.0	10.2	20.6	1.8	-4.5	2.6
Financial difficulties in last 2 years	2.0	2.7	4.7	-1.1	-2.2	-1.5
Medication: Blood pressure	2.0	3.4	6.5	0.2	2.6	-1.9
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.7	-2.2	0.2	-1.6
Hearing difficulty/problems: Yes	1.9	2.9	6.7	0.7	1.2	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	4.6	-1.9	-0.6	-2.2
Hearing difficulty/problems with background noise	1.9	3.0	6.7	-0.1	1.5	-2.6
Headache pain in last month	1.9	3.3	5.8	-2.4	-0.0	-2.0
Medication: Aspirin	1.9	2.4	6.5	-0.2	2.5	-0.9
Age started oral contraceptive pill	1.9	2.3	5.7	1.2	-0.0	2.4
Supplements: Zinc	1.7	1.8	2.3	-1.5	-1.3	-1.2
Medication: Cholesterol lowering	1.7	2.6	3.8	-0.6	2.0	-1.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	4.0	-1.8	-1.1	-2.0
Health satisfaction	1.7	2.2	3.9	-0.4	2.0	-1.6
Diabetes diagnosed by doctor	1.7	2.8	4.8	1.2	2.2	1.5
Medication: Atorvastatin	1.7	2.1	2.8	-1.4	-1.2	-1.7
Friendships satisfaction	1.6	2.0	3.3	-1.4	-1.8	-0.8
Myopia	1.6	2.4	4.3	-2.1	-0.8	-1.5
Verbal and Numeric Reasoning (VNR)	1.5	3.6	10.6	0.4	3.3	-0.4
HDL Cholesterol	1.5	2.5	3.4	1.8	-1.6	1.3
Triglycerides	1.5	2.4	4.1	-1.7	0.2	-2.0
Medication: Metformin	1.5	2.1	6.0	0.2	2.5	0.6
Gout (self-reported)	1.5	2.1	2.2	1.5	1.5	1.4
Medication: Omeprazole	1.5	1.8	2.5	-1.3	1.6	-1.1
Hand grip strength (left)	1.4	3.7	10.1	-0.8	-0.5	-3.2
Waist circumference	1.4	5.2	8.8	0.7	3.0	-2.5
Qualifications: None of the above	1.4	2.9	7.1	2.7	-0.1	1.3
Diabetes (self-reported)	1.4	2.1	5.0	0.6	2.2	1.0
Length of working week for main job	1.4	1.6	3.3	-0.4	-1.1	1.8
Suffer from ‘nerves’	1.4	2.2	3.6	1.9	-1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.1	-1.8	-1.0	-0.7
High cholesterol (Self-reported)	1.4	2.4	3.4	-1.4	1.4	-1.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	5.1	-0.7	0.1	-2.2
Schizophrenia (2018)	1.3	2.7	4.2	-1.9	-2.0	0.6
Hypothyroidism (self reported)	1.3	3.0	5.1	-2.3	-1.5	-1.3
Hair/balding pattern: Pattern 2	1.3	1.6	4.1	-0.6	-2.0	-0.7
Birth weight of first child	1.3	2.4	5.2	1.2	2.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	4.0	-0.9	2.0	-0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	1.7	1.0	0.9
Qualifications: nursing, teaching	1.3	2.0	2.6	-1.3	1.6	-1.2
Eye problems/disorders: Cataract	1.3	1.5	3.6	0.9	1.9	-0.2
Financial situation satisfaction	1.3	1.6	2.4	0.7	1.5	-1.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.8	-0.8	2.0	-0.5
Maternal smoking around birth	1.2	1.8	5.1	-0.4	-2.3	-0.1
Had other major operations	1.2	1.4	2.4	-1.6	-0.2	-1.4
Heart attack	1.2	1.5	4.2	-0.2	0.5	-2.0
Time employed in main current job	1.2	1.4	1.8	1.3	0.7	1.3
Depression (self-reported)	1.2	1.5	3.4	-0.8	0.6	-1.9
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.2	-1.5	0.1	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	1.1	0.1	1.8
Age at last live birth	1.2	1.8	2.3	1.5	0.9	1.5
Leg fat percentage (left)	1.2	4.4	9.2	0.3	3.0	-2.0
Number of operations (self-reported)	1.2	1.8	3.7	-1.3	-0.0	-1.9
Intelligence (Savage-Jansen 2018)	1.1	3.4	8.4	0.9	2.9	-1.0
Alzheimer’s Disease (in father)	1.1	1.2	3.2	0.6	1.8	-0.0
Ovarian Cancer	1.1	1.4	2.0	-1.4	-1.2	0.9
Coronary Artery Disease (CAD)	1.1	1.3	1.7	1.2	-0.9	1.3
Schizophrenia (2014)	1.1	2.4	3.2	-1.8	-1.8	0.9
Blood Platelet Count	1.1	12.3	30.2	-2.5	0.7	-5.5
Number of treatments/medications taken	1.1	2.0	2.9	-1.4	1.1	-1.7
Hand grip strength (right)	1.1	3.1	7.2	-0.9	-1.1	-2.7
Medication: Ramipril	1.1	1.4	2.6	-0.9	-0.9	-1.6
Hip circumference	1.1	4.6	6.9	0.7	2.6	-2.6
Leg fat percentage (right)	1.1	4.0	9.2	0.2	3.0	-1.6
Medication: Ibuprofen	1.1	1.3	1.9	1.4	-0.6	-1.2
Leg fat mass (right)	1.1	4.1	6.7	0.5	2.6	-2.3
Miserableness	1.1	1.8	2.9	-1.4	-0.9	-1.7
Eye problems/disorders: Glaucoma	1.1	1.3	3.2	1.8	0.8	0.2
Irritability	1.1	1.9	4.7	-1.0	-0.1	-2.2
Leg fat mass (left)	1.1	4.3	6.5	0.5	2.5	-2.5
Arm predicted mass (left)	1.1	5.3	14.0	0.4	1.4	-3.7
Reaction Time	1.0	1.9	2.9	-1.7	1.5	0.8
Age at First Birth	1.0	1.5	2.0	1.4	1.4	0.8
BMI	1.0	5.8	14.1	-0.2	1.8	-3.8
Relative age of first facial hair	1.0	2.0	4.6	0.8	0.8	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.4	-0.7	1.9	-0.2
High blood pressure	1.0	2.9	6.2	-0.7	1.4	-2.5
Lung cancer (father)	1.0	1.2	3.1	-0.2	1.8	0.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.3	1.8	0.3	-0.2
Heart disease (mother)	1.0	1.3	3.1	-1.8	-0.8	-0.2
Hypertension (Self-reported)	1.0	2.9	5.8	-0.6	1.6	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.3	0.3	1.8	-0.4
Loneliness, isolation	1.0	1.4	3.2	-1.0	-0.3	-1.8
Illnesses of father: None of the above (group 1)	1.0	1.2	1.8	1.3	0.5	1.2
Ever taken oral contraceptive pill	1.0	1.1	2.1	1.0	-0.5	1.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.5	0.7	-1.2	2.6
Alzheimer’s Disease (including proxy)	0.9	1.3	2.2	-1.1	1.5	-0.7
Major Depression (MDD)	0.9	1.0	1.6	-1.2	-0.4	-1.2
HbA1C	0.9	1.0	2.4	0.3	-0.7	-1.6
Neuroticism (2016)	0.9	1.3	2.8	1.0	1.7	-0.4
Primary Biliary Cirrhosis	0.9	1.2	1.7	-0.8	-1.3	-1.1
Qualifications: CSEs or equivalent	0.9	1.2	1.9	-0.6	-1.4	-1.1
Weight	0.9	4.4	6.6	0.8	2.4	-2.6
Father’s age at death	0.9	1.1	2.2	-1.5	-0.7	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.6	3.4	-1.8	-0.3	-1.1
Arm fat mass (right)	0.9	3.7	6.3	-0.2	2.2	-2.5
Blood clot in the leg (DVT)	0.9	1.2	2.8	-0.7	-1.7	0.5
Worry too long after embarrassment	0.9	1.5	3.2	1.1	1.8	0.3
Medication for pain relief, constipation, heartburn	0.9	1.6	3.1	-0.1	-1.3	1.8
Illnesses of father: Heart disease	0.9	1.2	2.2	-1.1	0.5	-1.5
Osteoarthritis (self-reported)	0.9	1.1	2.4	1.5	0.7	0.7
Medication: Blood pressure	0.9	1.7	2.0	-1.2	1.3	-1.4
Medication: Bendroflumethiazide	0.9	1.4	2.5	-1.1	1.6	-0.7
Arm fat-free mass (left)	0.9	4.4	11.3	0.4	1.3	-3.4
Commuting to job workplace: Cycle	0.9	1.0	1.7	1.3	1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	-1.0	1.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.1	-0.7	-1.8	0.3
Heart disease (siblings)	0.9	1.1	1.8	-1.4	-1.0	-0.5
Schizophrenia vs Biploar Disorder	0.8	1.0	1.3	-0.9	-0.9	1.1
Rheumatoid Arthritis	0.8	1.1	1.4	-1.1	-0.8	1.2
Average weekly spirits intake	0.8	1.0	1.6	1.3	1.1	-0.4
Diabetes (father)	0.8	0.9	2.1	1.5	0.7	0.3
Multivitamins +/- minerals	0.8	1.0	1.4	-1.1	0.6	-1.2
Body mass index (BMI)	0.8	3.6	6.5	0.5	2.6	-2.0
Noisy workplace	0.8	1.0	2.5	0.0	-1.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.3	1.1	-0.6	-1.2
Hair/balding pattern: Pattern 4	0.8	1.9	3.2	-1.4	0.7	-1.8
Body fat percentage	0.8	3.1	8.0	0.4	2.8	-1.1
Arm fat-free mass (right)	0.8	3.9	9.3	1.1	1.0	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.3	1.1	-0.8	1.1
Whole body fat mass	0.8	3.3	6.3	0.4	2.5	-1.9
Ever had bowel cancer screening	0.8	0.9	1.6	1.0	1.3	0.3
Medication for cholesterol	0.8	1.3	2.1	1.4	-1.3	0.2
Mother’s age at death	0.8	1.1	1.8	0.6	1.3	1.0
Medication: Lisinopril	0.8	1.1	1.6	-1.2	0.9	-0.9
Basal metabolic rate	0.8	4.3	10.9	0.4	1.3	-3.3
Cholesterol lowering medication	0.8	1.2	1.8	-1.4	1.2	-0.4
Bipolar Disorder (2018)	0.7	1.1	2.5	0.3	1.6	-0.8
Fasting Glucose	0.7	0.9	2.1	0.6	-1.4	-0.3
LDL Cholesterol	0.7	1.1	1.2	-1.0	-1.0	-1.1
Lung FEV1/FVC ratio	0.7	3.4	8.8	-1.2	3.0	0.1
Pack years adult smoking proportion	0.7	1.0	2.2	0.8	1.5	0.4
Average weekly fortified wine intake	0.7	0.8	2.2	-0.4	1.5	-0.0
Trunk fat mass	0.7	3.0	5.7	0.4	2.4	-1.7
Pain all over the body in last month	0.7	0.8	2.0	0.5	1.4	-0.4
Arm fat percentage (right)	0.7	2.7	5.7	-0.5	2.4	-1.5
Trunk fat-free mass	0.7	3.9	11.0	0.3	0.7	-3.3
Worrier / anxious feelings	0.7	1.3	2.1	-0.8	-1.1	-1.4
Trunk predicted mass	0.7	3.9	11.2	0.4	0.6	-3.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	1.4	0.6	0.5
Mean time to correctly identify matches	0.7	1.4	2.3	-1.5	1.0	1.0
Arm predicted mass (right)	0.7	3.5	7.8	1.4	1.0	-2.8
Pulse rate, automated reading	0.7	2.2	5.3	-2.3	1.1	0.3
Number of full sisters	0.7	0.9	1.7	1.3	0.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-0.5	-1.2	0.9
Supplements: Vitamin C	0.7	0.8	1.5	-0.9	-1.2	-0.3
Whole body fat-free mass	0.7	3.8	10.5	0.4	0.8	-3.2
Mood swings	0.7	1.3	3.6	-0.5	-0.0	-1.9
Long-standing illness, disability or infirmity	0.7	1.1	2.7	-0.6	1.6	-0.5
Whole body water mass	0.7	3.9	11.0	0.3	0.8	-3.3
Arm fat mass (left)	0.7	3.0	4.6	0.2	2.1	-2.1
Average weekly champagne plus white wine intake	0.7	0.9	2.2	-1.5	0.5	0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.2	0.3	-1.1	-1.1
Unable to work because of sickness or disability	0.7	0.9	2.3	0.3	0.6	-1.5
Pain experienced in last month	0.7	1.1	2.1	1.2	-0.1	1.4
Pack years of smoking	0.7	1.1	2.9	0.6	1.7	0.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.6	-1.1	-0.3	-1.6
Crohns Disease (2017)	0.6	1.3	2.2	-1.5	-1.0	0.9
Bipolar Disorder (2011)	0.6	0.6	1.3	-0.6	0.1	-1.1
Crohns Disease (2012)	0.6	0.9	2.5	-1.6	-0.4	-0.3
Mean Putamen Volume	0.6	0.7	2.0	-0.1	1.4	-0.3
Blood White Count	0.6	4.2	6.6	-2.6	-1.6	-1.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	0.3	-0.6	1.3
Medication: Co-codamol	0.6	0.7	1.0	0.7	-0.7	1.0
Severe depression (siblings)	0.6	0.7	1.8	-0.3	0.2	-1.3
Trunk fat percentage	0.6	2.6	6.9	0.4	2.6	-0.8
Serious illness, injury or assault to yourself	0.6	0.7	1.3	-0.1	-0.9	1.2
Stomach or abdominal pain in last month	0.6	0.7	1.0	-1.0	-0.5	-1.0
Number of incorrect matches in round	0.6	1.0	1.7	1.3	-0.9	-0.7
Forced vital capacity (FVC)	0.6	2.4	5.0	0.8	-2.2	-1.2
Fluid intelligence score	0.6	1.3	3.8	-0.0	2.0	-0.2
Happiness	0.6	0.7	1.5	1.2	-0.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	-0.8	-0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	0.1	1.3	-1.0
Glaucoma (self-reported)	0.6	0.7	2.2	1.5	0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.1	-1.1	-0.3	-1.4
High blood pressure (siblings)	0.6	0.9	1.4	-1.0	-1.2	-0.2
Forced vital capacity (FVC), Best measure	0.6	2.1	5.5	0.4	-2.3	-0.9
Qualifications: College or University degree	0.6	2.0	3.8	-1.5	1.9	-0.3
Eye problems/disorders: None of the above	0.6	0.7	2.1	-1.5	-0.1	0.2
Overall health rating	0.6	1.2	1.8	0.2	1.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	-0.1	1.4	0.2
Leg fat-free mass (right)	0.6	3.3	9.4	0.0	0.7	-3.1
Arm fat percentage (left)	0.6	2.2	5.2	-0.0	2.3	-1.2
Leg predicted mass (right)	0.6	3.2	9.3	0.1	0.6	-3.0
Diastolic blood pressure, automated reading	0.6	1.7	3.2	-1.8	0.3	-1.4
Ever depressed for a whole week	0.6	0.7	1.4	1.2	0.6	0.7
Depression (Nagel 2018)	0.5	0.8	1.5	-1.2	0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	0.9	0.9	0.3	-0.8
Waist Hip Ratio (WHR)	0.5	2.3	6.5	-0.6	0.1	-2.5
Allergy or Eczema	0.5	1.3	3.4	-1.8	0.1	0.7
Medication for hormone replacement therapy	0.5	0.6	1.5	0.5	1.2	-0.2
Leg fat-free mass (left)	0.5	2.8	8.0	0.1	0.7	-2.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.7	1.0	0.3
Supplements: Glucosamine	0.5	0.7	1.3	0.1	-1.1	-0.9
Leg predicted mass (left)	0.5	2.8	7.8	0.1	0.7	-2.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	0.2	-0.4	1.2
Allergy	0.5	1.2	2.9	-0.4	0.8	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.2	-0.4	-1.8	-1.1
Impedance of arm (left)	0.5	2.4	7.0	-0.1	-0.6	2.6
Breastfed as a baby	0.5	0.6	1.4	-1.2	0.3	-0.6
Loud music exposure frequency	0.5	0.5	0.8	0.9	-0.1	0.9
Comparative body size at age 10	0.5	1.5	2.6	1.6	0.6	1.2
Number of children fathered	0.5	0.6	1.7	1.3	-0.2	0.2
Medication: Allopurinol	0.5	0.7	1.8	0.5	0.1	1.4
Knee pain experienced in last month	0.5	0.8	1.8	1.3	-0.6	-0.5
Smoking status: Previous	0.5	0.8	1.1	-0.6	-1.1	-0.9
Breast cancer (self-reported)	0.5	0.6	1.4	-1.2	-0.5	-0.6
Smoking status: Current	0.5	0.8	1.7	1.3	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.9	0.0	-1.7	0.6
Impedance of whole body	0.5	2.3	6.6	0.6	-0.3	2.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.9	-0.3	0.7	-1.0
Systolic Blood Pressure	0.4	1.9	5.2	-0.7	-0.1	-2.3
Smoking Status	0.4	0.9	2.3	0.6	-1.5	0.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.7	-0.2	-0.1	-1.3
Angina	0.4	0.5	1.2	0.1	-0.5	-1.1
Impedance of leg (right)	0.4	2.1	5.6	0.7	0.6	2.4
Current tobacco smoking	0.4	0.6	1.5	1.2	-0.2	0.6
Medication: Levothyroxine sodium	0.4	0.7	1.2	-1.0	0.1	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	0.1	-1.2	0.4
Impedance of leg (left)	0.4	1.7	3.5	1.0	0.8	1.9
Illnesses of siblings	0.4	0.6	1.4	0.6	1.2	0.2
Impedance of arm (right)	0.4	2.1	5.0	-1.1	-0.2	2.2
Falls in the last year	0.4	0.5	0.7	0.8	-0.5	0.8
Number of live births	0.4	0.5	0.6	-0.8	-0.6	0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.4	0.3	-1.4
Shortness of breath walking on level ground	0.4	0.5	0.7	0.2	0.9	-0.8
Angina (self-reported)	0.4	0.6	1.4	0.0	-0.5	-1.2
Average weekly red wine intake	0.4	0.6	1.1	0.0	1.0	-0.8
Mineral and other dietary supplements	0.4	0.5	1.0	0.5	0.5	1.0
Asthma (self-reported)	0.4	0.8	1.8	1.3	-0.2	0.6
Guilty feelings	0.4	0.7	1.1	1.1	-0.9	0.0
Commuting to job workplace: Public transport	0.4	0.5	1.0	-1.0	0.0	-0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	1.2	-0.1	-0.2
Alcohol drinker status: Previous	0.4	0.4	0.5	-0.7	-0.7	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.6	1.6	-1.3	-0.5	-0.1
Lupus	0.3	0.4	1.1	0.2	1.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	0.2	1.2	-0.1
Sensitivity / hurt feelings	0.3	0.5	1.5	0.4	-1.2	0.1
Systolic blood pressure, automated reading	0.3	0.9	2.0	-0.4	0.6	-1.4
Vitamin and mineral supplements	0.3	0.5	1.2	0.2	-0.4	1.1
Townsend deprivation index at recruitment	0.3	0.4	0.7	0.1	-0.7	-0.8
Fed-up feelings	0.3	0.6	1.7	-0.1	-0.2	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-0.7	-0.3	1.1
Medication: Atenolol	0.3	0.4	0.8	-0.1	0.9	-0.6
Sitting height	0.3	2.0	4.2	1.3	0.0	-2.1
Nervous feelings	0.3	0.5	1.0	1.0	0.7	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	-0.3	-1.1	0.2
Neuroticism score	0.3	0.6	1.9	0.0	-0.2	-1.4
Asthma	0.3	0.5	1.5	1.2	0.2	0.2
Medication: Paracetamol	0.3	0.5	1.5	-0.0	-1.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.9	-0.2	0.4
Emphysema/chronic bronchitis	0.3	0.4	1.1	0.1	-1.0	-0.0
Comparative height size at age 10	0.3	1.4	2.6	0.8	-1.6	-1.0
Leg pain on walking	0.3	0.4	1.1	0.2	0.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	0.1	-0.7	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.1	0.8	-0.8
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.6	-0.9	0.4
Ever smoked	0.3	0.5	1.1	-0.6	-1.1	0.3
Worry (Nagel 2018)	0.2	0.5	1.0	0.3	-1.0	0.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.3	0.7	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	-0.6	-0.3	1.0
Ulcerative Colitis (UC)	0.2	0.4	0.5	0.7	0.7	0.6
Ulcerative Colitis	0.2	0.4	0.7	0.2	0.6	0.8
Respiratory disease	0.2	0.4	0.8	0.6	-0.1	0.9
Neuroticism	0.2	0.5	1.4	-0.4	-0.2	-1.2
Chronotype (morning person)	0.2	0.4	1.2	-0.4	-1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.6	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.4	0.3	0.6
Past tobacco smoking	0.2	0.3	0.9	0.3	1.0	-0.1
Hair/balding pattern: Pattern 3	0.2	0.4	0.9	-0.3	1.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	0.4	-1.0	-1.0
Tense / ‘highly strung’	0.2	0.4	0.8	-0.3	-0.9	-0.5
Medication: Amlodipine	0.2	0.2	0.4	-0.7	0.4	-0.3
Migraine (self-reported)	0.2	0.2	0.3	-0.3	-0.6	0.5
Family relationship satisfaction	0.2	0.3	0.6	0.5	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	1.0	-0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.3	0.7	0.2
Medication: Gliclazide	0.2	0.3	0.5	-0.5	0.1	0.7
Hearing aid user	0.2	0.3	0.4	0.5	0.6	0.4
Medication: Paracetamol	0.2	0.3	0.9	-0.0	-0.9	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	0.2	0.2	0.9
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.4	-0.6	-0.7
Blood Eosinophil Count	0.1	0.8	1.3	-0.5	-1.1	-0.9
Height	0.1	1.7	2.7	1.5	0.5	-1.6
Hair Pigment	0.1	2.9	5.7	-2.4	-1.7	-0.5
Tanning	0.1	1.8	3.0	1.7	-1.5	-0.2
Age when periods started (menarche)	0.1	0.2	0.5	0.3	0.7	0.3
Alcohol usually taken with meals	0.1	0.1	0.2	-0.3	0.1	0.4
Mouth/teeth dental problems	0.1	0.2	0.4	0.2	-0.5	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.4	0.6	0.3
Prospective memory result	0.1	0.1	0.2	-0.4	-0.5	-0.1
Standing height	0.1	1.2	3.1	0.7	-0.1	-1.8
Peak expiratory flow (PEF)	0.1	0.2	0.2	-0.5	0.5	-0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.5	0.2	-0.1	0.7
Number of full brothers	0.1	0.1	0.3	0.0	-0.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	-0.3	0.4
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.1	-0.1	-0.7
Alcohol intake frequency.	0.1	0.2	0.4	-0.4	0.7	0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.2	-0.4	-0.2
Back pain experienced in last month	0.1	0.1	0.3	0.0	0.3	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.3	-0.1	-0.2
Relative age voice broke	0.0	0.1	0.1	0.3	0.3	-0.0
Exposure to tobacco smoke at home	0.0	0.1	0.1	-0.2	0.3	0.1
Birth weight	0.0	0.0	0.0	0.1	0.2	-0.1
Wears glasses or contact lenses	0.0	0.0	0.1	0.3	0.2	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.3	0.2	-0.0

Hub : Genes

PFDN5

Models

Trait associations