[Hub]/) : Traits : Heel T-Score :

chr13:41,335,816-44,380,753

Best TWAS P=3.94e-32 · Best GWAS P=9.37e-152 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AKAP11 0.16 0.20 lasso 4 0.19 3.6e-23 -7.6 7.7 1.5e-14 -0.42 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex DNAJC15 0.60 0.72 lasso 2 0.72 1.6e-125 -5.5 5.5 4.6e-08 0.00 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous DNAJC15 0.45 0.35 lasso 3 0.39 2.2e-33 -5.5 5.2 1.5e-07 0.02 1.00 0.00 FALSE
4 GTEx Adrenal Gland RGCC 0.21 0.00 lasso 5 0.02 6.7e-02 -7.8 7.5 8.4e-14 -0.04 0.01 0.82 TRUE
5 GTEx Adrenal Gland DNAJC15 0.45 0.53 lasso 3 0.52 1.2e-21 -5.5 5.4 5.3e-08 0.00 1.00 0.00 FALSE
6 GTEx Artery Aorta AKAP11 0.26 0.09 lasso 11 0.11 7.7e-07 -6.3 6.5 8.1e-11 -0.34 0.58 0.07 FALSE
7 GTEx Artery Aorta DNAJC15 0.59 0.57 lasso 7 0.58 2.4e-38 -5.5 5.2 2.0e-07 0.00 1.00 0.00 FALSE
8 GTEx Artery Coronary DNAJC15 0.47 0.45 lasso 4 0.45 1.2e-16 -5.5 5.4 7.2e-08 0.01 1.00 0.00 FALSE
9 GTEx Artery Tibial AKAP11 0.17 0.11 lasso 4 0.14 4.3e-11 -8.5 8.5 1.3e-17 -0.40 1.00 0.00 FALSE
10 GTEx Brain Cerebellar Hemisphere AKAP11 0.21 0.20 lasso 6 0.19 1.6e-05 -8.3 8.5 2.7e-17 -0.42 0.24 0.35 FALSE
11 GTEx Brain Cerebellum AKAP11 0.30 0.29 enet 15 0.30 2.1e-09 -7.6 8.9 7.2e-19 -0.45 0.99 0.00 TRUE
12 GTEx Brain Cerebellum DNAJC15 0.52 0.42 enet 6 0.46 3.4e-15 -5.5 5.1 3.1e-07 0.01 1.00 0.00 FALSE
13 GTEx Brain Hippocampus DNAJC15 0.54 0.37 lasso 7 0.41 7.8e-11 -5.5 5.2 2.4e-07 0.01 0.96 0.00 FALSE
14 GTEx Brain Hypothalamus DNAJC15 0.31 0.29 lasso 3 0.23 3.9e-06 -5.1 5.1 2.8e-07 0.01 0.72 0.02 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia DNAJC15 0.46 0.32 lasso 8 0.37 6.8e-11 -5.5 5.3 1.2e-07 0.00 0.98 0.00 FALSE
16 GTEx Breast Mammary Tissue (Male) DNAJC15 0.61 0.51 lasso 5 0.49 5.0e-13 -5.5 5.3 1.1e-07 0.00 0.98 0.00 FALSE
17 GTEx Cells EBV-transformed lymphocytes DNAJC15 0.53 0.52 lasso 5 0.50 1.1e-18 -5.5 5.4 5.5e-08 0.01 1.00 0.00 FALSE
18 GTEx Cells Transformed fibroblasts DNAJC15 0.45 0.52 lasso 6 0.53 2.3e-46 -5.5 5.6 2.2e-08 0.00 1.00 0.00 FALSE
19 GTEx Colon Sigmoid AKAP11 0.21 0.06 lasso 4 0.09 4.0e-04 3.3 5.8 6.2e-09 -0.52 0.13 0.17 FALSE
20 GTEx Colon Sigmoid RGCC 0.21 -0.01 enet 26 0.02 6.5e-02 4.4 7.4 1.0e-13 -0.03 0.05 0.26 TRUE
21 GTEx Colon Sigmoid DNAJC15 0.71 0.60 lasso 8 0.61 1.3e-26 -5.5 5.2 2.4e-07 0.01 1.00 0.00 FALSE
22 GTEx Colon Transverse DNAJC15 0.46 0.44 lasso 5 0.43 6.3e-22 -5.5 5.4 6.4e-08 0.00 1.00 0.00 FALSE
23 GTEx Esophagus Gastroesophageal Junction AKAP11 0.17 -0.01 enet 21 -0.01 7.0e-01 -8.3 5.6 2.5e-08 -0.42 0.10 0.11 TRUE
24 GTEx Esophagus Mucosa AKAP11 0.25 0.18 lasso 9 0.17 1.6e-11 -7.9 9.5 2.2e-21 -0.53 1.00 0.00 FALSE
25 GTEx Esophagus Mucosa DNAJC15 0.56 0.54 lasso 5 0.57 1.1e-45 -5.5 5.4 7.1e-08 0.00 1.00 0.00 FALSE
26 GTEx Esophagus Muscularis AKAP11 0.23 0.19 lasso 4 0.19 2.1e-11 -7.7 7.9 2.5e-15 -0.43 1.00 0.00 FALSE
27 GTEx Esophagus Muscularis DNAJC15 0.43 0.44 lasso 8 0.46 4.5e-31 -5.5 5.3 9.1e-08 0.01 1.00 0.00 FALSE
28 GTEx Heart Left Ventricle DNAJC15 0.32 0.30 lasso 7 0.31 6.4e-17 -5.5 5.1 2.8e-07 0.01 1.00 0.00 FALSE
29 GTEx Liver DNAJC15 0.64 0.48 lasso 10 0.53 2.6e-17 -5.5 5.3 1.3e-07 0.01 1.00 0.00 FALSE
30 GTEx Lung AKAP11 0.08 0.00 lasso 2 0.02 1.8e-02 6.9 9.0 2.9e-19 -0.13 0.07 0.15 TRUE
31 GTEx Lung DNAJC15 0.47 0.60 lasso 3 0.60 2.5e-57 -5.5 5.5 4.6e-08 0.00 1.00 0.00 FALSE
32 GTEx Muscle Skeletal AKAP11 0.15 0.10 lasso 8 0.10 2.4e-10 -8.3 -7.6 4.0e-14 0.37 1.00 0.00 FALSE
33 GTEx Nerve Tibial AKAP11 0.12 0.00 enet 19 0.01 5.1e-02 11.1 9.3 1.1e-20 -0.37 0.36 0.04 TRUE
34 GTEx Pancreas DNAJC15 0.56 0.52 lasso 7 0.53 6.1e-26 -5.5 5.7 1.6e-08 0.01 1.00 0.00 FALSE
35 GTEx Pituitary DNAJC15 0.68 0.55 lasso 4 0.53 1.5e-15 -5.4 5.5 5.1e-08 0.00 1.00 0.00 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic AKAP11 0.14 0.00 enet 32 0.00 4.1e-01 2.3 7.2 6.4e-13 -0.36 0.14 0.12 FALSE
37 GTEx Skin Not Sun Exposed Suprapubic DNAJC15 0.46 0.50 lasso 5 0.50 5.6e-31 -5.5 5.3 1.5e-07 0.00 1.00 0.00 FALSE
38 GTEx Skin Sun Exposed Lower leg AKAP11 0.06 0.05 lasso 3 0.04 4.6e-04 -8.3 7.8 5.4e-15 -0.40 0.82 0.03 FALSE
39 GTEx Skin Sun Exposed Lower leg RGCC 0.08 0.01 enet 18 0.03 1.5e-03 -3.5 5.7 1.1e-08 -0.03 0.16 0.04 FALSE
40 GTEx Spleen DNAJC15 0.71 0.56 enet 20 0.63 2.3e-20 -5.5 5.2 2.3e-07 0.00 1.00 0.00 FALSE
41 GTEx Testis AKAP11 0.15 0.03 enet 13 0.09 6.4e-05 12.2 11.6 7.1e-31 -0.43 0.24 0.23 TRUE
42 GTEx Testis DNAJC15 0.43 0.38 lasso 3 0.36 1.3e-16 -5.5 5.2 1.6e-07 0.00 1.00 0.00 FALSE
43 GTEx Thyroid DNAJC15 0.43 0.35 lasso 9 0.35 5.6e-28 -5.5 5.6 2.5e-08 0.00 1.00 0.00 FALSE
44 GTEx Whole Blood DNAJC15 0.16 0.15 lasso 4 0.14 4.2e-13 -5.5 5.4 8.1e-08 0.01 1.00 0.00 FALSE
45 METSIM Adipose AKAP11 0.03 0.01 lasso 5 0.01 3.7e-02 -7.6 7.2 5.4e-13 -0.39 0.35 0.12 FALSE
46 METSIM Adipose DNAJC15 0.28 0.32 lasso 5 0.32 6.9e-49 -5.4 5.2 1.7e-07 0.00 1.00 0.00 FALSE
47 The Cancer Genome Atlas Bladder Urothelial Carcinoma DNAJC15 0.09 0.07 lasso 2 0.06 1.4e-05 -5.4 5.5 4.6e-08 0.00 0.00 1.00 FALSE
48 The Cancer Genome Atlas Breast Invasive Carcinoma AKAP11 0.05 0.01 enet 18 0.03 3.9e-06 -7.9 5.2 2.3e-07 -0.28 0.15 0.03 TRUE
49 The Cancer Genome Atlas Breast Invasive Carcinoma DNAJC15 0.18 0.28 enet 13 0.29 1.3e-60 -5.5 5.5 4.1e-08 0.00 0.00 1.00 FALSE
50 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DNAJC15 0.08 0.10 lasso 1 0.07 2.0e-04 -5.5 5.5 3.3e-08 0.00 0.01 0.99 FALSE
51 The Cancer Genome Atlas Colon Adenocarcinoma TNFSF11 0.14 0.01 blup 60 0.03 4.5e-03 -5.0 5.9 3.3e-09 -0.20 0.02 0.06 FALSE
52 The Cancer Genome Atlas Glioblastoma Multiforme DNAJC15 0.40 0.45 lasso 8 0.44 1.0e-14 -5.5 5.6 2.3e-08 0.00 0.01 0.99 FALSE
53 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DNAJC15 0.24 0.29 lasso 7 0.29 2.4e-33 -5.5 5.4 6.4e-08 0.01 0.00 1.00 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DNAJC15 0.32 0.37 lasso 4 0.39 1.8e-46 -5.4 5.4 5.7e-08 0.00 0.00 1.00 FALSE
55 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DNAJC15 0.38 0.21 blup 92 0.31 2.3e-18 -5.5 5.4 7.9e-08 0.00 0.00 1.00 FALSE
56 The Cancer Genome Atlas Brain Lower Grade Glioma AKAP11 0.03 0.00 blup 85 0.02 5.0e-03 -7.9 8.5 1.6e-17 -0.41 0.03 0.03 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma DNAJC15 0.32 0.38 lasso 5 0.46 8.8e-58 -5.5 5.3 9.5e-08 0.00 0.00 1.00 FALSE
58 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DNAJC15 0.36 0.35 lasso 4 0.34 1.4e-16 -5.4 5.4 5.3e-08 0.00 0.00 1.00 FALSE
59 The Cancer Genome Atlas Lung Adenocarcinoma DNAJC15 0.24 0.27 enet 12 0.27 2.0e-31 -5.5 5.6 1.8e-08 0.00 0.00 1.00 FALSE
60 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AKAP11 0.04 0.05 lasso 3 0.04 7.2e-06 -9.9 10.1 3.9e-24 -0.45 0.76 0.18 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DNAJC15 0.19 0.24 lasso 3 0.24 1.3e-26 -5.4 5.5 4.3e-08 0.00 0.01 0.99 FALSE
62 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma AKAP11 0.04 0.00 blup 85 0.02 2.1e-02 -8.4 11.8 3.9e-32 -0.50 0.04 0.35 TRUE
63 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DNAJC15 0.10 0.04 blup 92 0.04 7.8e-04 -5.4 5.4 5.8e-08 -0.01 0.01 0.94 FALSE
64 The Cancer Genome Atlas Pancreatic Adenocarcinoma DNAJC15 0.29 0.33 lasso 4 0.35 1.3e-15 -5.5 5.7 1.1e-08 0.01 0.01 0.99 FALSE
65 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma DNAJC15 0.32 0.28 lasso 7 0.31 4.5e-13 -5.5 5.5 4.3e-08 0.01 0.01 0.98 FALSE
66 The Cancer Genome Atlas Prostate Adenocarcinoma DNAJC15 0.17 0.21 lasso 4 0.21 4.0e-21 -5.5 5.6 2.6e-08 0.00 0.00 1.00 FALSE
67 The Cancer Genome Atlas Rectum Adenocarcinoma DNAJC15 0.38 0.28 enet 9 0.32 3.5e-08 -5.5 6.0 2.2e-09 0.00 0.01 0.98 TRUE
68 The Cancer Genome Atlas Soft Tissue Sarcoma DNAJC15 0.18 0.16 lasso 3 0.15 5.9e-09 -5.5 5.5 4.0e-08 0.01 0.00 1.00 FALSE
69 The Cancer Genome Atlas Thyroid Carcinoma AKAP11 0.07 0.09 lasso 3 0.08 3.7e-08 -7.6 7.6 3.3e-14 -0.41 1.00 0.00 FALSE
70 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma DNAJC15 0.16 0.06 blup 92 0.10 1.0e-03 -5.4 5.2 1.9e-07 0.00 0.02 0.88 FALSE