TWAS hub - TNFAIP8L3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1210	0.0380	7.3e-08	0.067	0.086	0.069	0.086	0.080	1.3e-08	1.2e-10	9.6e-09	1.4e-10	5.1e-10
2	GTEx	Colon Sigmoid	0.2210	0.0810	5.4e-04	0.016	NA	0.028	NA	0.005	8.6e-02	NA	3.6e-02	NA	2.0e-01
3	GTEx	Heart Left Ventricle	0.1107	0.0470	4.9e-03	0.022	NA	0.006	NA	0.003	2.3e-02	NA	1.4e-01	NA	2.0e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0278	0.0166	8.4e-03	-0.001	0.014	0.010	NA	0.001	4.4e-01	8.3e-03	2.4e-02	NA	2.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Heel T-Score	5.2	41.4	118.8	-5.5	1.0	10.9	4.0
Sitting height	5.2	36.9	59.6	-7.7	-5.1	-2.0	7.6
Height	4.7	91.1	198.8	-14.1	-2.4	-6.9	10.6
Sensitivity / hurt feelings	4.7	8.1	17.8	-4.2	-2.1	-0.6	3.1
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.8	14.2	-3.4	-2.8	-2.4	3.8
Pain type(s) experienced in last month: Hip pain	4.5	5.6	11.0	-3.3	-2.3	0.9	2.3
Heel bone mineral density (BMD) T-score, automated (left)	4.4	10.0	17.4	-3.3	-0.5	4.2	3.4
Standing height	4.1	40.9	90.1	-9.5	-1.1	-5.1	6.8
Worry too long after embarrassment	4.1	6.8	10.4	-2.4	-2.9	1.7	3.2
Tinnitus: Yes, now most or all of the time	3.7	4.3	12.0	-3.5	-0.3	1.6	1.5
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.2	15.7	-2.9	-1.3	4.0	2.7
Hearing difficulty/problems: Yes	3.5	5.4	11.0	-2.5	-2.0	0.0	3.3
Lung FEV1/FVC ratio	3.3	17.0	30.1	4.4	4.1	1.4	-5.5
Breast Cancer	3.2	7.6	15.5	3.9	0.1	-3.6	-1.3
Waist Hip Ratio (WHR)	3.0	13.5	18.8	3.1	3.0	-4.3	-4.1
Gout (self-reported)	3.0	4.1	5.9	2.4	1.9	2.0	-1.6
Hand grip strength (right)	2.9	7.9	15.7	-4.0	-1.4	0.0	3.7
Had major operations	2.9	3.4	7.9	-1.1	-2.8	-0.7	2.0
Hearing difficulty/problems with background noise	2.8	4.4	7.4	-2.4	-2.2	0.3	2.7
Alzheimer’s Disease (including proxy)	2.7	3.9	7.6	1.6	2.8	0.8	-2.3
Mean time to correctly identify matches	2.6	5.0	10.2	1.5	2.5	-1.3	-3.2
Leg fat-free mass (right)	2.6	14.0	22.7	-4.5	-2.8	-2.2	4.8
Leg predicted mass (right)	2.6	13.8	22.2	-4.5	-2.8	-2.2	4.7
Pack years of smoking	2.6	3.9	8.6	1.8	1.8	-0.2	-2.9
Hand grip strength (left)	2.5	6.5	13.1	-3.5	-0.9	-0.4	3.6
Medication: Ramipril	2.5	3.2	5.2	2.1	1.6	-0.8	-2.3
Forced vital capacity (FVC), Best measure	2.5	9.1	26.9	-2.8	0.6	-5.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	4.7	1.7	-0.3	1.8	-2.2
Supplements: Calcium	2.5	2.7	5.6	1.8	1.2	0.7	-2.4
Neuroticism (Nagel 2018)	2.4	5.5	6.9	-2.6	-2.4	-1.8	2.5
Maternal smoking around birth	2.4	3.5	5.7	-2.1	-2.4	0.0	2.0
Forced vital capacity (FVC)	2.4	9.3	28.9	-2.7	0.3	-5.4	1.0
Age at last live birth	2.4	3.5	9.4	0.6	3.1	-2.0	-0.5
Alcohol drinker status: Never	2.4	2.9	5.1	2.2	1.0	-1.7	-1.6
Blood White Count	2.3	17.3	32.9	5.7	2.7	0.5	-5.3
Medication: Blood pressure	2.3	4.5	9.4	3.1	0.9	-0.1	-2.8
Pain experienced in last month	2.3	3.9	8.3	2.3	2.9	-0.2	-1.3
Alzheimer’s Disease (in father)	2.2	2.3	3.5	1.4	1.9	-0.7	-1.9
Leg predicted mass (left)	2.2	11.5	17.7	-4.2	-2.5	-2.1	4.2
Chronic bronchitis/emphysema (mother)	2.2	2.6	7.4	-0.9	-2.7	0.2	1.4
Medication for cholesterol	2.2	3.3	7.4	-1.7	-1.4	0.8	2.7
Diastolic blood pressure, automated reading	2.2	6.9	11.2	3.1	1.4	-2.2	-3.4
Leg fat-free mass (left)	2.1	11.0	16.8	-4.1	-2.4	-2.1	4.1
Trunk fat-free mass	2.1	11.9	20.5	-4.5	-2.3	-3.3	3.4
Whole body fat-free mass	2.1	11.9	19.5	-4.4	-2.4	-2.7	3.9
Whole body water mass	2.1	11.8	19.5	-4.4	-2.5	-2.6	3.8
Hip circumference	2.0	8.4	15.7	-3.2	-2.7	0.7	4.0
Forced expiratory volume in 1-second (FEV1)	2.0	6.8	20.8	-2.0	1.5	-4.6	-0.2
Depression (self-reported)	2.0	2.4	4.3	-1.4	-2.1	-0.1	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	19.1	-1.9	1.6	-4.4	-0.5
Trunk predicted mass	2.0	11.6	20.1	-4.5	-2.2	-3.2	3.3
Illnesses of father: Heart disease	2.0	2.8	6.0	-2.5	-0.7	1.0	1.9
Depressed Affect (Nagel 2018)	1.9	4.0	5.9	-2.4	-1.9	-1.5	2.1
Hypertension (Self-reported)	1.9	5.2	10.2	3.2	0.3	-1.5	-2.8
Smoking status: Previous	1.9	2.8	7.2	-2.7	-1.1	0.8	1.5
Basal metabolic rate	1.9	10.6	17.0	-4.1	-2.3	-2.6	3.6
Risk taking	1.9	2.8	5.4	-1.9	-0.6	2.3	1.3
Alzheimer’s Disease (in mother)	1.8	2.2	3.0	1.7	1.5	0.7	-1.7
Triglycerides	1.8	3.0	6.7	1.8	-2.6	-0.6	-1.4
Chronotype (morning person)	1.8	4.2	10.3	2.5	0.2	-0.4	-3.2
Medication: Lansoprazole	1.8	2.1	4.6	1.9	0.5	-0.2	-2.1
Medication: Amlodipine	1.8	2.6	4.6	1.1	2.1	-0.7	-2.0
Chest pain or discomfort	1.8	2.5	6.1	-0.0	-1.7	-2.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.0	-1.0	-2.0	-1.2	1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	3.4	1.5	0.8	-1.8	-1.6
Reaction Time	1.7	3.2	6.2	1.2	1.2	-1.9	-2.5
Relative age of first facial hair	1.7	3.5	13.0	-0.2	0.9	-3.6	0.1
Hair/balding pattern: Pattern 3	1.7	2.5	5.6	-1.8	-0.6	-1.0	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.0	-0.6	-1.8	-2.5	1.0
Arm fat-free mass (right)	1.7	8.5	15.2	-3.9	-2.2	-2.2	3.1
Neck or shoulder pain in last month	1.7	2.5	6.7	-1.7	-2.6	0.1	0.6
Medication: Aspirin	1.7	2.3	3.9	1.4	0.5	-1.7	-2.0
Supplements: Vitamin C	1.7	2.0	6.7	-2.6	0.8	-0.1	0.9
Commuting to job workplace: Walk	1.7	1.8	4.1	-0.5	-2.0	1.6	0.5
Asthma (self-reported)	1.7	3.3	10.2	1.2	-3.2	0.8	1.1
Basal cell carcinoma (self-reported)	1.7	2.1	4.8	-2.2	-0.9	-0.0	1.6
Depression (Nagel 2018)	1.6	2.4	3.6	-1.1	-1.9	-1.7	1.3
Neuroticism	1.6	3.9	5.4	-1.7	-2.3	-1.8	2.0
Pack years adult smoking proportion	1.6	2.5	5.7	1.4	1.5	-0.4	-2.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	5.1	1.0	-2.2	-0.9	-0.8
Neuroticism score	1.6	3.4	5.0	-1.6	-2.2	-1.6	1.9
Asthma	1.6	3.2	9.6	1.4	-3.1	0.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.5	-0.5	-2.3	-0.9	1.3
Arm predicted mass (right)	1.6	7.9	13.8	-3.7	-2.3	-1.9	3.0
Comparative height size at age 10	1.6	8.8	18.9	-4.3	0.9	-3.1	2.4
Mood swings	1.6	2.9	4.3	-2.1	-2.0	-0.1	1.8
Vascular/heart problems diagnosed by doctor	1.6	4.3	9.5	-3.1	-0.7	0.8	2.6
Neuroticism (2016)	1.5	2.2	6.9	1.3	-0.3	-2.6	-0.1
Supplements: Zinc	1.5	1.7	4.5	-1.2	-0.3	-2.1	0.7
Relative age voice broke	1.5	2.2	4.5	1.3	2.1	-1.6	-0.4
Had menopause	1.5	1.9	5.9	0.5	0.1	2.4	-1.1
Age at first live birth	1.5	2.6	9.3	-0.7	3.0	-0.4	0.8
Number of full sisters	1.5	1.9	5.6	-0.8	-2.4	-0.8	0.8
Loneliness, isolation	1.5	2.1	3.8	1.9	-1.7	-1.2	-0.4
Major Depression (MDD)	1.4	1.7	3.9	-2.0	-0.2	-0.4	1.6
Crohns Disease (2012)	1.4	2.3	5.9	-0.9	-1.6	-0.4	2.4
Fed-up feelings	1.4	2.6	3.6	-1.8	-1.5	-1.9	1.2
High blood pressure	1.4	3.8	8.2	2.9	0.3	-1.0	-2.4
Tense / ‘highly strung’	1.4	2.3	4.0	1.6	0.9	-2.0	-1.4
Back pain experienced in last month	1.4	2.1	4.5	-1.2	-2.1	-1.4	0.7
Medication: Aspirin	1.4	1.8	4.1	1.2	0.4	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.3	1.7	1.1	-1.2	-2.5
Arm fat-free mass (left)	1.4	7.1	12.5	-3.5	-2.4	-1.7	2.7
Fasting Glucose	1.3	1.5	3.0	-0.0	-1.1	-1.7	1.4
Ever had hysterectomy (womb removed)	1.3	1.5	2.7	0.4	-1.5	-1.6	1.0
Nervous feelings	1.3	2.4	6.8	-0.8	-2.6	0.5	1.4
Breastfed as a baby	1.3	1.7	3.4	-0.8	1.6	1.9	0.3
Pulse wave reflection index	1.3	1.6	3.5	-0.5	1.9	0.6	1.4
Angina (self-reported)	1.3	1.7	3.0	1.7	0.1	-1.4	-1.4
Migraine (self-reported)	1.3	1.6	3.9	-1.5	-0.5	-0.2	2.0
Ever depressed for a whole week	1.3	1.6	2.7	-1.2	-0.5	-1.6	1.3
Myopia	1.3	1.8	3.1	1.2	1.6	0.3	-1.8
Schizophrenia (2018)	1.2	2.4	5.2	-1.5	0.0	1.5	2.3
Age at First Birth	1.2	1.7	2.9	1.7	1.2	-0.8	-1.4
Schizophrenia (2014)	1.2	2.8	5.6	-2.4	-0.0	1.2	2.0
Blood Red Count	1.2	11.7	19.4	2.3	4.4	-1.7	-4.4
Smoking Status	1.2	3.0	4.9	-2.2	-1.6	-0.3	2.1
Systolic blood pressure, automated reading	1.2	3.6	9.4	3.1	0.4	-0.1	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.7	-0.4	-1.2	-2.2	-0.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	4.0	-1.0	1.0	-2.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.8	-0.1	-2.0	-1.9	0.1
Worrier / anxious feelings	1.2	2.3	4.9	-1.6	-1.0	-1.0	2.2
Number of children fathered	1.2	1.3	2.2	-1.3	-1.5	-0.1	1.1
Health satisfaction	1.2	1.6	4.1	-1.4	-0.1	-0.5	2.0
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	2.5	0.2	0.0	-1.5
Miserableness	1.2	2.1	5.1	-1.1	-2.2	-0.3	1.4
Arm predicted mass (left)	1.2	6.1	10.2	-3.2	-2.3	-1.8	2.4
Worry (Nagel 2018)	1.1	2.4	3.5	-1.1	-1.8	-1.9	1.2
Body Mass Index (BMI) (2010)	1.1	1.5	2.8	1.4	-1.7	1.1	0.0
Ulcerative Colitis	1.1	1.6	2.0	1.3	1.4	-1.4	-1.0
Medication: Atenolol	1.1	1.4	4.0	0.9	2.0	0.3	-0.7
Past tobacco smoking	1.1	2.1	5.6	2.4	1.2	-0.5	-1.1
Father’s age at death	1.1	1.4	2.6	1.3	1.1	1.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	4.1	-1.1	-0.8	-2.0	1.0
Falls in the last year	1.1	1.5	3.0	-1.4	-0.8	-1.7	0.6
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.8	1.6	-1.2	-0.6
Wheeze or whistling in the chest in last year	1.1	1.9	4.1	1.4	-1.3	-2.0	-0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.2	-1.8	0.4	-0.1	1.3
Ulcerative Colitis (UC)	1.0	1.8	3.9	1.3	1.3	-0.0	-2.0
Cardiovascular Disease	1.0	3.3	9.8	1.0	1.2	-3.1	-1.1
Angina	1.0	1.2	2.5	1.6	-0.2	-1.2	-1.0
Average weekly fortified wine intake	1.0	1.2	2.7	-1.6	0.9	-0.4	1.0
Serious illness, injury or assault to yourself	1.0	1.2	2.4	1.5	-0.2	-0.3	-1.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.4	1.1	-1.6	-1.1	-0.1
Pain all over the body in last month	1.0	1.1	1.5	-0.7	-1.1	-1.2	1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	0.2	-0.8	-1.5	1.5
Weight	1.0	4.9	8.6	-2.9	-1.5	-1.5	2.5
Illnesses of mother	1.0	1.2	2.3	-1.0	-1.1	-0.3	1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.7	-1.6	0.0	1.9	0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.3	0.8	-2.1	-0.3	0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.3	1.1	0.1	-1.8	-0.5
Medication: Allopurinol	1.0	1.4	2.6	1.6	1.1	1.0	-0.9
Medication: Seretide 50 evohaler	1.0	1.1	2.5	-0.5	-1.6	0.5	1.2
Average weekly red wine intake	1.0	1.4	3.5	-1.0	0.2	1.9	1.1
Ever smoked	1.0	1.7	3.4	-1.8	-1.3	0.6	1.1
Number of operations (self-reported)	1.0	1.4	3.5	0.0	-1.9	-0.5	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.1	0.7	1.4	-1.0	-1.2
HbA1C	0.9	1.0	3.3	0.7	0.1	-1.8	0.2
Respiratory disease	0.9	2.1	4.1	1.4	-2.0	1.1	1.0
Severe depression (siblings)	0.9	1.0	2.6	-0.0	-0.8	-0.8	1.6
Impedance of leg (right)	0.9	4.4	8.4	0.9	2.9	-1.1	-2.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.5	-0.0	-1.1	-1.6	-0.3
Supplements: Glucosamine	0.9	1.2	4.2	-2.1	0.4	-0.2	0.6
Allergy	0.9	2.0	4.1	-0.6	2.0	-0.1	-1.9
Lung cancer (father)	0.9	1.1	1.8	1.3	-1.3	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.1	-2.0	0.3	0.2	0.5
Leg fat percentage (right)	0.9	3.4	6.8	2.5	0.5	0.7	-2.6
Overall health rating	0.9	1.9	5.3	0.9	-0.9	-2.3	-0.6
Long-standing illness, disability or infirmity	0.9	1.4	2.9	-0.4	-1.7	-1.4	0.8
Qualifications: nursing, teaching	0.9	1.4	4.9	-0.5	2.2	-0.6	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.4	-1.8	0.6	0.6	0.5
Irritability	0.9	1.5	4.3	-2.1	0.8	-0.8	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.9	-1.1	0.3	0.4	1.7
Fractured/broken bones in last 5 years	0.9	1.1	1.8	1.3	0.4	-1.0	-1.2
Crohns Disease (2017)	0.8	1.8	3.4	-0.9	-1.6	-0.6	1.9
Coronary Artery Disease (CAD)	0.8	1.0	2.8	0.8	1.7	0.3	-0.5
Systolic Blood Pressure	0.8	4.0	8.9	3.0	-0.1	-1.6	-2.1
Lung FVC	0.8	3.9	10.3	-0.6	2.0	-3.2	-0.9
Townsend deprivation index at recruitment	0.8	1.1	2.0	0.3	-1.4	-1.1	-0.9
Financial difficulties in last 2 years	0.8	1.1	2.9	-0.6	-1.7	0.7	0.9
Heart attack	0.8	1.0	2.1	0.5	1.4	-0.8	-1.0
Peak expiratory flow (PEF)	0.8	1.9	3.6	-1.9	0.3	-1.7	0.9
Birth weight	0.8	1.8	3.3	-1.2	-1.4	-0.7	1.8
Average weekly champagne plus white wine intake	0.8	1.1	2.5	1.6	0.0	-1.2	-0.6
Wears glasses or contact lenses	0.8	0.9	2.8	1.7	0.2	0.5	-0.8
Mother’s age at death	0.8	1.0	2.4	1.0	0.4	0.8	-1.5
Commuting to job workplace: Public transport	0.8	1.0	2.6	1.6	0.1	-0.2	-1.1
Age started oral contraceptive pill	0.8	1.1	3.7	0.5	0.4	1.9	-0.0
Heart disease (siblings)	0.8	1.0	2.4	1.5	-0.4	0.0	-1.3
Prostate Cancer	0.7	1.0	2.5	0.3	1.2	0.1	-1.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	1.3	0.4	-1.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.6	-0.3	-1.6	0.7	-0.3
Current tobacco smoking	0.7	1.2	4.1	0.3	-2.0	-0.4	0.7
Qualifications: CSEs or equivalent	0.7	1.0	2.0	0.8	0.6	-1.4	-0.9
Birth weight of first child	0.7	1.3	2.4	-1.3	0.9	-1.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.2	-0.9	1.1	0.1	1.1
Medication for pain relief, constipation, heartburn	0.7	1.1	4.0	0.6	2.0	0.1	0.2
Osteoarthritis (self-reported)	0.7	0.9	3.1	0.2	0.5	-1.8	-0.2
Hearing aid user	0.7	0.7	2.2	-0.1	-0.9	0.0	1.5
Medication: Bendroflumethiazide	0.7	1.0	2.6	1.0	0.4	0.5	-1.6
Medication: Paracetamol	0.7	1.0	3.0	-0.9	-1.7	0.3	0.4
Leg fat percentage (left)	0.7	2.6	5.2	2.1	0.3	0.7	-2.3
Bipolar Disorder or Schizophrenia	0.6	1.5	2.3	-1.5	0.8	1.0	1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	-1.6	-0.5	0.6	0.2
Blood Eosinophil Count	0.6	4.3	10.9	3.3	0.4	-0.4	-2.5
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-0.2	-1.3	-0.9	0.8
Impedance of leg (left)	0.6	3.1	6.9	0.3	2.6	-1.1	-2.0
Number of incorrect matches in round	0.6	1.0	2.2	-1.0	-0.7	1.5	0.7
Medication: Simvastatin	0.6	0.8	1.7	0.9	0.5	-1.3	-0.6
Pulse rate	0.6	1.1	3.4	-0.4	-1.8	-0.8	-0.3
Number of full brothers	0.6	0.8	2.8	-0.5	-0.1	-1.7	-0.1
Leg pain on walking	0.6	0.7	2.5	-0.3	-1.6	0.5	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.4	0.3	0.7	-1.5	-0.3
Guilty feelings	0.6	0.9	2.2	-0.7	-1.5	-0.4	0.8
Unable to work because of sickness or disability	0.6	0.7	2.1	-0.2	-0.5	-1.5	0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.2	0.6	-1.5	0.1	0.4
Alcohol drinker status: Previous	0.6	0.7	1.8	-0.1	0.6	0.8	-1.3
Medication for hormone replacement therapy	0.5	0.5	0.8	-0.7	-0.8	-0.9	-0.2
Vitamin and mineral supplements	0.5	0.7	1.7	1.3	-1.1	0.1	0.3
Medication: Co-codamol	0.5	0.6	1.1	1.0	0.5	-1.0	-0.3
Diabetes (mother)	0.5	0.7	1.7	0.6	-0.7	-1.3	-0.2
Stomach or abdominal pain in last month	0.5	0.7	1.4	-0.8	-1.2	0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-0.4	-1.0	-1.1	0.3
Diabetes (self-reported)	0.5	0.8	1.6	1.1	-1.3	-0.6	-0.0
Fluid intelligence score	0.5	1.1	2.6	0.0	-1.6	0.2	1.4
Impedance of arm (right)	0.5	2.6	6.5	-1.3	2.5	-1.3	0.6
Time employed in main current job	0.5	0.5	1.7	0.5	0.4	0.1	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.6	-0.0	1.9	0.6	0.4
Impedance of arm (left)	0.5	2.3	4.5	-1.7	2.1	-0.9	1.0
Blood clot in the leg (DVT)	0.5	0.7	1.5	-0.1	-0.4	-1.2	0.9
Medication: Paracetamol	0.5	0.9	1.7	-1.3	-1.3	-0.2	0.5
Comparative body size at age 10	0.5	1.4	3.2	1.8	1.0	0.7	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.9	-0.2	-0.4	-0.7	1.4
Qualifications: College or University degree	0.5	1.6	4.6	-0.9	0.7	0.7	2.1
Medication: Ibuprofen	0.5	0.6	1.9	-0.3	-1.4	-0.4	0.3
Medication: Omeprazole	0.5	0.6	2.3	0.3	-1.5	-0.4	0.1
Pulse rate, automated reading	0.5	1.8	3.9	0.2	-1.6	-2.0	-0.7
Alcohol intake frequency.	0.5	1.2	2.6	1.5	0.0	0.0	-1.6
Suffer from ‘nerves’	0.5	0.8	1.4	0.8	-0.4	-1.2	-1.0
Mineral and other dietary supplements	0.5	0.7	1.3	0.9	-1.1	-0.2	0.8
Ever taken oral contraceptive pill	0.5	0.6	0.8	-0.9	-0.5	-0.8	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.5	0.7	-0.2	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.8	-0.0	-0.5	-1.3	0.8
Bipolar Disorder (2018)	0.4	0.6	1.6	-0.5	1.3	-0.2	-0.6
Allergy or Eczema	0.4	1.0	2.0	0.3	-1.4	-0.7	1.1
Hypothyroidism (self reported)	0.4	1.0	2.3	-0.2	-0.9	1.5	0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.4	0.9	-1.2	-0.9	0.3
Diabetes (father)	0.4	0.5	1.4	-1.2	-0.6	-0.2	0.6
Multivitamins +/- minerals	0.4	0.4	1.0	-0.2	1.0	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	2.1	-0.7	0.6	-1.4	-0.0
Medication: Cholesterol lowering	0.4	0.6	1.4	-0.2	-1.2	-0.5	1.0
Prospective memory result	0.4	0.5	1.3	0.9	0.1	0.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	0.5	-1.3	1.0	0.7
Eye problems/disorders: None of the above	0.4	0.5	1.1	1.1	0.2	-0.2	-0.9
Medication: Blood pressure	0.4	0.8	1.2	1.1	0.1	0.9	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.5	-1.1	0.6	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.4	-0.2	0.3	1.2	-0.5
Ever had bowel cancer screening	0.4	0.5	1.7	0.2	0.3	-0.3	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	0.7	-1.4	-0.3	-0.5
Medication: Gliclazide	0.4	0.5	1.9	-0.0	-1.4	0.2	-0.3
Smoking status: Current	0.4	0.7	2.1	0.5	-1.4	-0.7	-0.0
Illnesses of father: High blood pressure	0.4	0.5	1.7	0.0	-1.3	-0.1	0.6
Cholesterol lowering medication	0.4	0.5	1.8	0.0	1.4	-0.5	-0.1
Impedance of whole body	0.4	1.9	5.9	-0.9	2.4	-1.0	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.6	-0.2	-0.8	-0.7	1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	0.1	-1.0	1.0	0.9
Ovarian Cancer	0.3	0.4	0.9	-0.0	0.9	-0.9	-0.1
Bipolar Disorder (2011)	0.3	0.2	0.3	0.5	0.6	-0.4	-0.5
LDL Cholesterol	0.3	0.4	0.7	0.6	-0.5	-0.8	-0.5
Primary Biliary Cirrhosis	0.3	0.5	1.6	1.3	-0.2	-0.2	-0.5
Average weekly spirits intake	0.3	0.3	0.5	-0.5	-0.5	0.6	0.7
Trunk fat mass	0.3	1.5	2.9	-1.7	-0.3	-0.5	1.6
Alcohol usually taken with meals	0.3	0.5	1.0	1.0	-0.3	-0.8	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.9	-0.8	-0.1	-0.5
Qualifications: None of the above	0.3	0.7	1.5	0.4	-0.7	-1.2	-0.7
Mouth/teeth dental problems	0.3	0.4	1.2	0.6	-0.1	1.1	-0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.0	0.5	-0.1	1.0	0.8
Number of live births	0.3	0.5	1.3	0.3	-0.7	-1.1	0.1
Happiness	0.3	0.4	0.7	0.8	-0.1	-0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.9	0.2	-0.4	0.6
Loud music exposure frequency	0.3	0.3	0.6	-0.7	0.5	0.8	-0.2
Headache pain in last month	0.3	0.4	1.0	-0.5	-1.0	0.2	0.7
High blood pressure (siblings)	0.3	0.4	1.5	-0.2	0.1	-1.2	-0.2
Heart disease (mother)	0.3	0.4	1.4	-0.0	0.0	1.2	0.6
Family relationship satisfaction	0.3	0.4	1.2	0.4	1.1	-0.5	0.2
Diabetes diagnosed by doctor	0.3	0.5	1.0	1.0	-0.3	-0.8	-0.6
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.7	-0.9	-0.2	0.3
Osteoporosis (self-reported)	0.3	0.3	0.5	-0.4	-0.6	-0.4	0.7
Medication: Lisinopril	0.3	0.4	1.0	0.5	-1.0	-0.5	0.1
Mean Putamen Volume	0.2	0.2	0.5	-0.0	0.7	0.0	-0.6
HDL Cholesterol	0.2	0.3	0.9	-0.3	0.5	-0.9	0.3
Rheumatoid Arthritis	0.2	0.3	1.2	0.0	-0.2	1.1	0.1
Blood Platelet Count	0.2	2.3	5.2	2.3	-0.9	0.7	-1.6
BMI	0.2	0.9	1.9	1.4	-1.4	0.0	0.0
Number of treatments/medications taken	0.2	0.4	0.7	0.2	-0.8	0.5	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.2	-1.0	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	0.2	-1.0	0.1	0.3
Medication: Metformin	0.2	0.3	1.1	0.4	0.2	-0.1	-1.0
Age when periods started (menarche)	0.2	0.6	0.9	0.2	0.9	-1.0	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	0.1	-0.4	-0.3	1.3
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.6	-0.9	0.4	0.1
High blood pressure (mother)	0.2	0.2	0.6	0.8	-0.0	0.6	-0.3
Body mass index (BMI)	0.2	0.9	1.6	1.2	-1.1	0.7	-0.5
Illnesses of siblings	0.2	0.3	0.8	-0.9	0.1	0.4	0.4
Noisy workplace	0.2	0.2	0.6	0.1	-0.6	0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	0.0	-0.5	-1.0	-0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	-0.3	0.0	-0.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.7	0.3	0.1	0.7
Glaucoma (self-reported)	0.2	0.3	0.5	-0.4	0.5	-0.3	-0.7
Whole body fat mass	0.2	0.7	1.3	-1.1	-0.5	-0.6	1.1
Illnesses of siblings: Diabetes	0.2	0.3	1.2	0.1	0.0	-1.1	-0.1
Friendships satisfaction	0.2	0.2	0.7	0.8	0.3	-0.4	-0.1
Arm fat mass (left)	0.2	0.9	1.5	-0.8	-1.2	-0.5	1.1
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.2	0.4	-0.8	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.5	-0.5	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.1	0.1	0.3	0.5	-0.1	-0.6	-0.1
Lupus	0.1	0.1	0.5	-0.3	-0.7	0.0	-0.1
Trunk fat percentage	0.1	0.2	0.5	-0.5	0.4	0.1	0.7
Had other major operations	0.1	0.1	0.2	0.4	-0.0	0.0	-0.4
Arm fat percentage (right)	0.1	0.5	1.6	1.2	-0.0	0.2	-0.5
Arm fat mass (right)	0.1	0.4	0.7	-0.5	-0.8	-0.4	0.8
Length of working week for main job	0.1	0.1	0.4	-0.6	0.1	-0.1	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.5	-0.8	0.1	-0.5
Body fat percentage	0.1	0.2	0.3	0.6	0.5	0.4	-0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.4	-0.6	-0.5	-0.2	0.2
Pulse wave peak to peak time	0.1	0.1	0.4	-0.2	-0.2	-0.1	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.2	-0.2	0.4	0.3
Knee pain experienced in last month	0.1	0.2	0.5	-0.3	-0.3	-0.7	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.1	0.2	-0.1	-0.5
Arm fat percentage (left)	0.1	0.3	1.2	1.1	-0.2	0.3	-0.2
Breast cancer (self-reported)	0.1	0.1	0.4	-0.2	0.6	0.2	-0.3
Financial situation satisfaction	0.1	0.2	0.5	0.2	-0.7	-0.2	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.8	-0.1	-0.9	-0.2	-0.2
Leg fat mass (left)	0.1	0.2	0.8	-0.3	-0.9	-0.1	0.3
Hair Pigment	0.0	0.9	2.0	-0.2	-0.6	1.1	1.4
Tanning	0.0	0.2	0.3	-0.0	-0.6	-0.4	0.4
Taking other prescription medications	0.0	0.0	0.1	-0.1	-0.2	0.1	0.3
Waist circumference	0.0	0.2	0.5	0.2	-0.4	-0.7	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.0
Leg fat mass (right)	0.0	0.1	0.3	-0.0	-0.6	-0.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.0	-0.0	-0.4	-0.3
Medication: Atorvastatin	0.0	0.1	0.1	-0.1	0.3	0.3	0.0

Hub : Genes

TNFAIP8L3

Models

Trait associations