[Hub]/) : Traits : Heel T-Score :

chr17:36,211,659-37,644,854

Best TWAS P=1.07e-15 · Best GWAS P=1.09e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PCGF2 0.14 0.12 lasso 2 0.12 6.1e-10 -6.2 -6.9 4.4e-12 -0.28 0.99 0.00 FALSE
2 GTEx Adipose Subcutaneous PSMB3 0.11 0.01 enet 8 0.03 2.7e-03 6.4 5.7 1.0e-08 0.66 0.01 0.94 FALSE
3 GTEx Adipose Subcutaneous PIP4K2B 0.15 0.07 lasso 5 0.07 2.2e-06 8.0 7.7 1.5e-14 0.95 0.00 1.00 FALSE
4 GTEx Adrenal Gland PCGF2 0.34 0.09 lasso 6 0.11 8.5e-05 -6.2 -6.4 1.6e-10 -0.35 0.08 0.62 FALSE
5 GTEx Artery Aorta PCGF2 0.51 0.32 enet 27 0.37 1.2e-21 -6.2 -6.4 2.0e-10 -0.31 1.00 0.00 FALSE
6 GTEx Artery Aorta PSMB3 0.23 0.17 enet 26 0.22 2.1e-12 8.0 7.0 3.3e-12 0.84 0.00 1.00 FALSE
7 GTEx Artery Tibial PCGF2 0.38 0.27 lasso 8 0.31 4.3e-25 -6.2 -6.9 4.2e-12 -0.32 1.00 0.00 FALSE
8 GTEx Artery Tibial PSMB3 0.10 0.02 enet 12 0.03 1.2e-03 8.0 6.5 1.0e-10 0.73 0.00 0.99 FALSE
9 GTEx Artery Tibial PIP4K2B 0.37 0.16 enet 49 0.22 2.1e-17 8.0 6.3 3.1e-10 0.76 0.00 1.00 FALSE
10 GTEx Cells Transformed fibroblasts PCGF2 0.34 0.28 lasso 4 0.30 3.2e-23 -6.2 -5.7 1.1e-08 -0.21 1.00 0.00 FALSE
11 GTEx Colon Transverse PCGF2 0.29 0.21 lasso 5 0.20 6.2e-10 -6.2 -6.4 1.3e-10 -0.21 0.98 0.01 TRUE
12 GTEx Esophagus Mucosa PCGF2 0.32 0.24 lasso 7 0.23 1.8e-15 -6.2 -6.5 6.0e-11 -0.25 1.00 0.00 FALSE
13 GTEx Esophagus Muscularis PCGF2 0.21 0.15 lasso 8 0.13 3.3e-08 -6.2 -6.3 3.2e-10 -0.20 0.96 0.02 FALSE
14 GTEx Heart Atrial Appendage PCGF2 0.18 0.13 lasso 3 0.09 6.1e-05 -6.2 -6.1 9.8e-10 -0.18 0.29 0.07 FALSE
15 GTEx Lung PCGF2 0.25 0.17 lasso 7 0.17 4.8e-13 -6.2 -5.8 5.6e-09 -0.18 1.00 0.00 FALSE
16 GTEx Nerve Tibial PCGF2 0.20 0.07 lasso 4 0.13 3.1e-09 3.1 -5.7 1.5e-08 -0.30 0.71 0.12 TRUE
17 GTEx Pancreas PCGF2 0.29 0.12 lasso 5 0.07 5.3e-04 -6.2 -7.0 3.1e-12 -0.33 0.08 0.19 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic PCGF2 0.39 0.23 lasso 4 0.21 6.9e-12 -6.2 -6.3 3.8e-10 -0.20 1.00 0.00 FALSE
19 GTEx Skin Sun Exposed Lower leg PCGF2 0.36 0.30 lasso 7 0.32 1.3e-26 -6.2 -5.8 7.6e-09 -0.17 1.00 0.00 FALSE
20 GTEx Testis PSMB3 0.30 0.24 lasso 4 0.21 8.9e-10 8.0 8.0 1.1e-15 1.00 0.00 1.00 TRUE
21 METSIM Adipose PIP4K2B 0.06 0.01 blup 360 0.02 7.0e-04 5.1 5.2 2.3e-07 0.50 0.01 0.98 FALSE
22 NTR Blood PIP4K2B 0.02 0.01 lasso 3 0.01 6.4e-04 8.0 -7.2 5.5e-13 -0.97 0.00 0.99 FALSE
23 YFS Blood PCGF2 0.03 0.02 enet 7 0.03 2.1e-11 -6.2 -6.9 5.0e-12 -0.31 0.72 0.26 FALSE
24 YFS Blood PSMB3 0.14 0.11 enet 31 0.16 7.2e-49 7.9 6.5 6.3e-11 0.81 0.00 1.00 FALSE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma PCGF2 0.14 0.06 blup 35 0.11 1.1e-09 -4.0 -5.9 4.3e-09 -0.37 0.99 0.00 FALSE
26 The Cancer Genome Atlas Bladder Urothelial Carcinoma PSMB3 0.04 0.00 blup 37 0.02 6.7e-03 5.1 6.7 1.8e-11 0.72 0.01 0.67 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma PCGF2 0.06 0.06 blup 37 0.05 4.4e-11 -6.2 -6.2 7.0e-10 -0.38 1.00 0.00 TRUE
28 The Cancer Genome Atlas Colon Adenocarcinoma PCGF2 0.23 0.23 lasso 3 0.22 9.8e-13 -6.2 -6.7 2.4e-11 -0.24 1.00 0.00 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PIP4K2B 0.04 0.01 blup 56 0.03 6.3e-04 7.9 7.9 2.8e-15 0.83 0.00 0.93 TRUE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PSMB3 0.14 0.05 blup 42 0.05 8.9e-07 7.9 5.7 9.7e-09 0.70 0.00 1.00 FALSE
31 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PCGF2 0.11 0.00 blup 37 0.03 1.0e-02 4.8 -5.4 5.9e-08 -0.44 0.01 0.06 FALSE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CISD3 0.11 0.06 blup 33 0.04 1.9e-03 -4.0 5.2 1.8e-07 0.25 0.12 0.11 FALSE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PCGF2 0.08 0.00 blup 37 0.01 3.8e-02 -2.4 -5.4 5.3e-08 -0.33 0.02 0.06 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma PCGF2 0.28 0.16 lasso 4 0.13 3.4e-06 -6.2 -7.5 7.6e-14 -0.39 0.46 0.14 FALSE
35 The Cancer Genome Atlas Prostate Adenocarcinoma PCGF2 0.18 0.14 lasso 4 0.16 2.4e-16 -6.2 -7.6 2.9e-14 -0.39 1.00 0.00 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma PIP4K2B 0.05 0.04 blup 56 0.05 5.3e-06 7.6 7.4 1.0e-13 0.86 0.00 0.99 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma PSMB3 0.11 0.07 blup 42 0.07 9.4e-08 8.0 5.6 2.6e-08 0.77 0.00 1.00 FALSE
38 The Cancer Genome Atlas Soft Tissue Sarcoma PCGF2 0.18 0.05 blup 36 0.11 7.3e-07 -2.8 -7.1 1.6e-12 -0.56 0.08 0.85 FALSE
39 The Cancer Genome Atlas Stomach Adenocarcinoma PCGF2 0.14 0.04 enet 8 0.16 6.8e-12 3.1 -6.4 1.5e-10 -0.41 0.90 0.03 FALSE
40 The Cancer Genome Atlas Testicular Germ Cell Tumors PSMB3 0.12 0.09 lasso 3 0.06 3.0e-03 7.9 7.9 2.1e-15 0.97 0.00 0.94 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma PSMB3 0.05 0.06 lasso 1 0.05 2.4e-05 8.0 8.0 1.1e-15 1.00 0.00 1.00 FALSE