TWAS hub - CISD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.486	0.115	0.00063	0.081	NA	0.097	NA	0.121	4.5e-03	NA	0.0020	NA	0.0006
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.106	0.048	0.00066	0.063	0.035	0.024	NA	0.031	4.8e-05	0.0019	0.0088	NA	0.0035

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung FEV1/FVC ratio	10.1	51.1	102.0	-0.5	10.1
Peak expiratory flow (PEF)	6.4	14.8	29.1	0.8	5.4
Primary Biliary Cirrhosis	6.1	8.8	17.5	-0.3	4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.1	10.8	21.5	0.3	4.6
Pulse rate, automated reading	5.0	16.2	32.3	0.2	-5.7
Seen doctor (GP) for nerves, anxiety, tension or depression	4.9	7.5	11.9	-3.5	-1.8
Smoking status: Previous	4.7	7.0	10.6	-1.8	3.3
Depression (Nagel 2018)	4.3	6.5	11.2	-3.3	-1.4
Medication: Ventolin 100micrograms inhaler	4.3	5.5	8.2	1.7	-2.9
Neuroticism (2016)	4.2	6.0	11.6	0.7	-3.4
Heart disease (mother)	4.2	5.1	9.9	0.6	-3.1
Frequency of depressed mood in last 2 weeks	3.7	5.2	6.7	-2.6	-2.0
Glaucoma (self-reported)	3.7	4.4	8.4	2.9	0.5
Fed-up feelings	3.3	6.0	7.1	-2.2	-2.7
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	22.3	-0.1	4.7
Overall health rating	3.3	7.1	13.2	-1.0	-3.6
Hayfever, allergic rhinitis or eczema	3.2	7.0	12.7	-1.1	-3.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	10.0	19.2	-0.9	4.4
Supplements: Calcium	3.1	3.4	4.4	-1.6	-2.1
Medication: Atenolol	3.0	3.7	5.9	-1.2	-2.4
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	5.4	-2.3	-2.1
Allergy	2.9	6.6	12.5	0.8	3.5
Happiness	2.9	3.6	5.9	-1.1	-2.4
Financial situation satisfaction	2.9	3.5	7.0	-0.4	-2.6
Fractured/broken bones in last 5 years	2.9	3.7	4.1	-1.8	-2.0
Exposure to tobacco smoke at home	2.8	3.2	6.3	0.3	-2.5
Hair/balding pattern: Pattern 4	2.8	6.7	11.0	3.3	-1.6
Chronic bronchitis/emphysema (mother)	2.8	3.2	5.0	-1.2	-2.2
Friendships satisfaction	2.8	3.4	6.2	-0.8	-2.5
Tinnitus: Yes, now most or all of the time	2.7	3.2	4.6	2.1	1.3
Wheeze or whistling in the chest in last year	2.5	4.5	7.8	-1.1	-2.8
Loneliness, isolation	2.5	3.4	6.6	-0.5	-2.6
Neuroticism	2.4	5.8	9.9	-1.3	-3.1
Neuroticism score	2.4	4.9	9.1	-0.9	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	4.7	-2.2	-1.2
Osteoporosis (self-reported)	2.4	3.0	5.9	-0.2	-2.4
Age when periods started (menarche)	2.3	5.4	8.3	1.6	2.9
Illnesses of mother	2.3	2.8	4.7	-1.0	2.2
Health satisfaction	2.3	3.0	5.3	-0.8	-2.3
Heel T-Score	2.2	17.7	27.2	2.9	5.2
Respiratory disease	2.2	5.0	9.9	0.3	-3.1
Supplements: Zinc	2.2	2.4	4.5	-2.1	-0.6
Medication: Co-codamol	2.2	2.5	5.0	-2.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	3.9	-1.4	-2.0
Supplements: Glucosamine	2.2	2.8	5.5	-0.3	2.4
Past tobacco smoking	2.2	3.9	4.4	2.1	-1.9
Length of working week for main job	2.2	2.4	2.5	1.6	1.5
Neck or shoulder pain in last month	2.2	3.1	6.2	0.0	-2.5
Illnesses of father: None of the above (group 1)	2.2	2.7	4.3	1.0	2.1
Eye problems/disorders: Glaucoma	2.2	2.6	5.0	2.2	0.5
Number of operations (self-reported)	2.2	3.3	5.6	-2.4	-1.0
Nervous feelings	2.1	4.0	7.9	-0.3	-2.8
Number of children fathered	2.1	2.4	2.8	-1.4	1.7
Family relationship satisfaction	2.1	2.6	4.3	-1.0	-2.1
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	5.3	-0.2	-2.3
Supplements: Vitamin C	2.0	2.3	4.6	-2.1	-0.2
Smoking Status	1.9	4.5	6.6	-1.5	2.6
Number of full brothers	1.9	2.4	4.7	2.2	0.2
Medication: Blood pressure	1.9	3.6	6.3	-0.9	-2.5
Alcohol drinker status: Never	1.9	2.3	3.3	1.8	1.1
Depressed Affect (Nagel 2018)	1.8	3.7	6.8	-0.8	-2.6
Allergy or Eczema	1.8	4.8	8.8	-0.9	-3.0
Number of treatments/medications taken	1.8	3.2	6.3	-0.4	-2.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.6	-2.1	-0.3
Vitamin and mineral supplements	1.8	2.5	3.0	1.4	1.7
Number of incorrect matches in round	1.8	3.0	5.8	-2.4	0.5
Trunk fat-free mass	1.8	10.5	21.0	-4.6	-0.2
Time employed in main current job	1.8	2.0	3.6	-1.9	-0.7
Trunk predicted mass	1.8	10.4	20.8	-4.6	-0.3
Chest pain or discomfort	1.8	2.6	2.8	-1.5	-1.7
Had major operations	1.8	2.1	4.2	-2.0	-0.2
Illnesses of siblings: Diabetes	1.8	2.2	2.7	1.6	-1.3
Average weekly beer plus cider intake	1.8	2.6	4.6	0.8	-2.1
Sensitivity / hurt feelings	1.7	2.9	3.3	-1.6	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	6.3	1.1	2.5
Father’s age at death	1.7	2.3	4.5	0.1	2.1
Asthma (self-reported)	1.7	3.3	6.5	0.4	-2.5
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.3	-1.8	-0.7
Impedance of whole body	1.7	8.5	16.9	4.1	0.4
Neuroticism (Nagel 2018)	1.6	3.7	7.2	0.3	-2.7
Alzheimer’s Disease (in mother)	1.6	1.9	3.8	0.2	1.9
Prostate Cancer	1.6	2.2	4.3	-2.1	0.3
Hand grip strength (left)	1.6	4.2	5.6	-1.7	2.4
Hand grip strength (right)	1.6	4.5	8.9	-0.2	3.0
Medication: Lansoprazole	1.6	1.8	2.5	-1.6	1.1
Whole body fat-free mass	1.6	9.2	18.4	-4.3	0.0
Whole body water mass	1.6	8.9	17.7	-4.2	-0.0
Risk taking	1.6	2.3	4.0	0.8	2.0
Myopia	1.6	2.3	2.6	1.4	-1.6
Worry (Nagel 2018)	1.5	3.2	6.0	0.6	-2.4
Alzheimer’s Disease (in father)	1.5	1.7	2.3	1.0	-1.5
Major Depression (MDD)	1.5	1.8	3.4	-1.8	-0.5
Breast Cancer	1.5	3.6	5.4	1.3	-2.3
Severe depression (siblings)	1.5	1.7	3.2	-0.5	-1.8
Stomach or abdominal pain in last month	1.5	1.8	3.6	0.1	-1.9
Mouth/teeth dental problems	1.5	2.3	4.5	0.4	2.1
Illnesses of siblings	1.5	2.2	4.1	-0.5	2.0
Asthma	1.5	3.0	5.7	0.4	-2.4
Impedance of arm (left)	1.5	6.7	13.3	3.6	-0.4
Qualifications: nursing, teaching	1.5	2.3	2.9	-1.3	1.7
Arm fat-free mass (left)	1.5	7.5	15.1	-3.9	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	3.6	1.7	1.9
Medication: Omeprazole	1.4	1.7	3.3	-1.8	-0.0
Suffer from ‘nerves’	1.4	2.2	4.5	0.1	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	2.6	1.6	-1.3
Wears glasses or contact lenses	1.4	1.6	3.2	1.8	-0.2
Medication: Bendroflumethiazide	1.4	2.1	4.2	-0.3	-2.0
Triglycerides	1.3	2.0	3.0	-1.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.0	-0.1	1.7
Arm fat-free mass (right)	1.3	6.7	13.2	-3.6	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.0	-1.7	-0.4
Arm predicted mass (right)	1.3	6.6	13.1	-3.6	0.1
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.0	-0.3	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	2.7	-1.6	0.2
Basal metabolic rate	1.3	7.5	14.9	-3.9	-0.0
Irritability	1.3	2.3	4.6	-0.1	-2.1
Ever depressed for a whole week	1.3	1.5	1.7	-1.2	1.3
Commuting to job workplace: Cycle	1.3	1.5	3.0	-0.3	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.7	-0.8	1.6
Arm predicted mass (left)	1.3	6.5	13.0	-3.6	-0.1
Ovarian Cancer	1.2	1.5	1.9	-1.4	-1.1
Chronotype (morning person)	1.2	2.9	5.7	0.1	2.4
Hearing difficulty/problems: Yes	1.2	1.8	3.4	0.5	-1.8
Leg fat-free mass (left)	1.2	6.4	12.7	-3.6	-0.2
Impedance of leg (left)	1.2	6.0	11.6	3.4	0.5
Leg predicted mass (left)	1.2	6.5	13.0	-3.6	-0.2
Hair/balding pattern: Pattern 2	1.2	1.6	2.3	-0.9	1.5
Birth weight of first child	1.2	2.1	4.1	-2.0	-0.3
Worry too long after embarrassment	1.2	2.0	3.1	1.0	-1.8
Emphysema/chronic bronchitis	1.2	1.3	1.7	-1.3	-1.0
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.7	1.0	1.3
Hypertension (Self-reported)	1.2	3.3	5.5	-1.1	-2.4
Ever taken oral contraceptive pill	1.2	1.3	1.7	-1.0	1.3
Mother’s age at death	1.2	1.5	2.5	0.7	1.6
Cholesterol lowering medication	1.2	1.8	3.5	0.3	-1.9
Age at First Birth	1.1	1.6	3.0	1.7	-0.3
Diabetes (father)	1.1	1.4	2.3	-1.5	-0.7
Medication for cholesterol	1.1	1.6	3.2	-0.3	1.8
Number of self-reported non-cancer illnesses	1.1	1.9	3.1	-0.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.6	-1.6	0.4
Multivitamins +/- minerals	1.0	1.2	1.9	-0.7	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.2	0.1	-1.8
Medication: Ramipril	1.0	1.3	1.7	-1.0	-1.3
Depression (self-reported)	1.0	1.3	1.3	-1.1	-1.1
Blood clot in the leg (DVT)	1.0	1.3	2.1	-0.7	1.5
Angina (self-reported)	1.0	1.3	2.6	-0.2	-1.6
Long-standing illness, disability or infirmity	1.0	1.6	1.9	-1.1	-1.4
Leg predicted mass (right)	1.0	5.3	10.5	-3.2	-0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.2	1.6	-0.9	-1.3
Rheumatoid Arthritis	0.9	1.3	2.3	0.6	1.5
Blood Eosinophil Count	0.9	7.1	14.1	-0.3	-3.8
Townsend deprivation index at recruitment	0.9	1.2	2.4	0.1	-1.5
High blood pressure	0.9	2.6	4.6	-0.8	-2.1
Impedance of arm (right)	0.9	4.2	8.1	2.8	-0.6
Hair/balding pattern: Pattern 3	0.9	1.4	1.8	-1.0	-1.3
Gout (self-reported)	0.9	1.2	1.6	-0.9	1.2
Leg fat-free mass (right)	0.9	4.9	9.9	-3.1	-0.1
Mood swings	0.9	1.7	2.1	-1.2	-1.4
Body Mass Index (BMI) (2010)	0.8	1.1	2.2	-1.5	0.1
Blood White Count	0.8	6.2	12.2	0.5	-3.5
Angina	0.8	1.1	2.1	0.1	-1.5
Medication: Metformin	0.8	1.1	1.9	0.5	1.4
Weight	0.8	4.0	8.1	-2.8	0.2
Pulse rate	0.8	1.3	2.7	0.1	-1.6
Medication: Ibuprofen	0.8	1.0	1.0	1.0	1.0
Medication: Allopurinol	0.8	1.1	1.3	-1.1	1.0
Number of full sisters	0.8	1.0	1.9	-1.4	0.3
Commuting to job workplace: Public transport	0.8	1.0	1.4	-1.2	-0.7
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.2	0.2	2.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.9	1.7	0.5
HDL Cholesterol	0.7	1.2	2.3	1.5	-0.1
Blood Platelet Count	0.7	8.2	16.5	-0.1	-4.1
Cardiovascular Disease	0.7	2.4	4.4	-0.6	-2.1
Sitting height	0.7	5.2	9.2	-3.0	1.1
High blood pressure (mother)	0.7	1.0	1.7	-0.4	-1.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.1	-0.7	-1.0
Loud music exposure frequency	0.7	0.8	1.6	-1.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	-0.3	1.2
Alcohol intake frequency.	0.7	1.7	3.1	0.5	-1.8
Knee pain experienced in last month	0.7	1.1	1.2	-1.1	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	-1.3	-0.0
Miserableness	0.7	1.2	1.7	-1.3	-0.9
Unable to work because of sickness or disability	0.7	0.9	1.6	0.4	-1.3
Schizophrenia (2018)	0.6	1.2	2.3	0.2	-1.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.0	0.6	1.0
Pack years adult smoking proportion	0.6	1.0	1.7	0.5	-1.3
Impedance of leg (right)	0.6	3.0	6.0	2.5	0.2
Taking other prescription medications	0.6	1.0	1.4	0.7	-1.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	0.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.9	-0.7	1.0
Medication: Levothyroxine sodium	0.6	1.0	1.6	1.3	0.7
Forced vital capacity (FVC)	0.6	2.3	4.5	-0.4	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	1.2	0.5
Pulse wave reflection index	0.6	0.7	1.4	-0.2	1.2
Mean time to correctly identify matches	0.6	1.2	2.0	0.6	1.4
Comparative height size at age 10	0.6	3.5	6.6	-2.6	-0.6
Commuting to job workplace: Walk	0.6	0.6	0.7	-0.8	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	0.8	-0.9	-0.8
Smoking status: Current	0.6	1.0	1.5	-0.7	-1.2
Heart disease (siblings)	0.6	0.8	1.5	1.2	-0.3
Pack years of smoking	0.6	1.0	1.7	0.4	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	-0.2	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.8	1.0	1.0	0.7
Crohns Disease (2012)	0.5	0.8	0.9	-0.8	1.0
LDL Cholesterol	0.5	0.8	1.5	0.3	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.1	-0.1	-1.0
Lung FVC	0.5	2.7	5.0	0.7	2.2
Financial difficulties in last 2 years	0.5	0.7	1.4	1.2	0.3
Noisy workplace	0.5	0.6	1.0	0.3	-1.0
Standing height	0.5	4.8	9.7	-3.1	0.0
Tense / ‘highly strung’	0.5	0.8	1.6	-0.0	-1.3
Birth weight	0.5	1.2	2.4	-1.5	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.9	3.0	-0.9	1.7
Comparative body size at age 10	0.5	1.3	2.6	0.2	1.6
Pulse wave peak to peak time	0.5	0.6	1.0	0.5	1.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	0.4	1.2
Leg fat mass (right)	0.5	1.8	3.6	-1.9	0.2
Medication: Aspirin	0.5	0.6	1.2	-0.3	-1.1
Back pain experienced in last month	0.5	0.7	1.3	-0.4	1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.0	-0.5	-1.0
Medication: Atorvastatin	0.5	0.6	1.1	1.1	-0.3
Ever smoked	0.5	0.8	1.0	-1.0	0.8
Fasting Glucose	0.4	0.4	0.7	0.9	0.3
Medication for hormone replacement therapy	0.4	0.5	0.7	0.5	0.8
Number of live births	0.4	0.5	1.0	0.1	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	0.4	-1.3
Breastfed as a baby	0.4	0.5	0.8	0.4	-0.9
Illnesses of father: Heart disease	0.4	0.6	1.0	0.4	-1.0
Breast cancer (self-reported)	0.4	0.5	1.0	-1.0	0.3
Osteoarthritis (self-reported)	0.4	0.6	0.9	-0.5	1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-1.0	0.4
Guilty feelings	0.4	0.6	1.1	-0.0	-1.1
High cholesterol (Self-reported)	0.4	0.7	1.3	-0.2	-1.1
Bipolar Disorder (2018)	0.3	0.4	0.6	-0.4	-0.8
Schizophrenia (2014)	0.3	0.7	1.5	-0.0	-1.2
BMI	0.3	2.0	3.3	-1.8	0.9
Average weekly spirits intake	0.3	0.3	0.6	0.8	-0.2
Diabetes (mother)	0.3	0.4	0.5	0.7	-0.5
Maternal smoking around birth	0.3	0.4	0.9	0.9	0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.5	0.7	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.1	-0.8
Body mass index (BMI)	0.3	1.3	2.5	-1.6	0.3
Waist circumference	0.3	1.1	2.0	-1.4	-0.5
Alcohol usually taken with meals	0.3	0.5	0.9	-0.1	1.0
Had other major operations	0.3	0.4	0.8	-0.9	-0.1
Pain all over the body in last month	0.3	0.4	0.6	0.3	-0.8
Worrier / anxious feelings	0.3	0.6	0.7	0.9	-0.6
Falls in the last year	0.3	0.4	0.7	-0.1	-0.9
Lung cancer (father)	0.3	0.4	0.5	-0.5	0.7
Arm fat mass (right)	0.3	1.4	2.7	-1.6	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.4	-0.7	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.6	-0.6	-0.8
Qualifications: College or University degree	0.3	0.9	1.4	-1.2	0.7
Medication: Blood pressure	0.3	0.5	0.8	-0.4	-0.9
Whole body fat mass	0.3	1.3	2.4	-1.5	0.4
Eye problems/disorders: Cataract	0.3	0.3	0.5	-0.7	0.4
Arm fat mass (left)	0.3	1.1	2.2	-1.5	0.2
Hearing aid user	0.3	0.3	0.4	-0.6	0.6
Diastolic blood pressure, automated reading	0.3	0.9	1.4	0.6	-1.2
Leg fat mass (left)	0.3	1.3	2.5	-1.6	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.9	0.7	0.9
Crohns Disease (2017)	0.2	0.4	0.7	-0.1	0.9
Mean Putamen Volume	0.2	0.2	0.3	-0.5	0.3
HbA1C	0.2	0.2	0.2	0.4	-0.5
Lupus	0.2	0.3	0.6	0.8	-0.0
Ulcerative Colitis	0.2	0.2	0.4	-0.6	-0.2
Height	0.2	3.1	6.0	-2.4	-0.4
Hair Pigment	0.2	4.9	6.0	2.0	2.5
Systolic blood pressure, automated reading	0.2	0.5	1.0	1.0	-0.1
Current tobacco smoking	0.2	0.4	0.7	-0.2	-0.8
Average weekly fortified wine intake	0.2	0.3	0.5	-0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.2	-0.5	0.5
Trunk fat mass	0.2	0.8	1.3	-1.2	0.4
Qualifications: None of the above	0.2	0.4	0.7	0.3	-0.9
Medication: Simvastatin	0.2	0.3	0.6	-0.1	-0.8
Hip circumference	0.2	1.0	1.7	-1.3	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.1	0.6
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.2
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.2	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.6	0.2
Age at last live birth	0.2	0.3	0.5	0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.3	0.9
Medication: Aspirin	0.2	0.2	0.4	-0.2	-0.7
Medication: Gliclazide	0.2	0.2	0.2	0.5	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	0.3
Pain experienced in last month	0.2	0.4	0.7	-0.8	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.2	-0.5
Reaction Time	0.1	0.2	0.4	0.1	0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.1	0.4
Waist Hip Ratio (WHR)	0.1	0.4	0.5	-0.7	-0.6
Systolic Blood Pressure	0.1	0.6	0.9	0.5	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.6	-0.3
Tanning	0.1	0.8	1.5	-1.2	0.3
Relative age of first facial hair	0.1	0.2	0.4	0.6	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	0.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.0	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	0.0
Diabetes (self-reported)	0.1	0.1	0.2	0.3	-0.4
Fluid intelligence score	0.1	0.3	0.3	0.5	0.6
Prospective memory result	0.1	0.1	0.2	0.4	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	-0.4	-0.5
Medication: Paracetamol	0.1	0.1	0.3	0.2	-0.5
Headache pain in last month	0.1	0.1	0.3	0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.0	0.5
Medication: Amlodipine	0.1	0.1	0.2	0.2	-0.5
High blood pressure (siblings)	0.1	0.1	0.2	-0.4	-0.1
Leg fat percentage (right)	0.1	0.2	0.4	-0.6	0.1
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.2	-0.6
Age at first live birth	0.1	0.3	0.5	-0.7	0.1
Leg pain on walking	0.1	0.1	0.1	-0.1	-0.4
Ever had bowel cancer screening	0.1	0.1	0.2	0.2	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.2	0.3	-0.5
Mineral and other dietary supplements	0.1	0.1	0.2	0.4	0.3
Medication: Paracetamol	0.1	0.1	0.2	0.2	-0.4
Medication: Lisinopril	0.1	0.2	0.3	0.2	-0.5
Age started oral contraceptive pill	0.1	0.1	0.1	0.1	0.4
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.2	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	0.4	0.6	0.6
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.2	-0.4
Trunk fat percentage	0.0	0.1	0.3	0.2	0.5
Relative age voice broke	0.0	0.0	0.0	0.1	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.1	-0.1
Had menopause	0.0	0.0	0.0	0.0	-0.2
Heart attack	0.0	0.0	0.0	-0.2	-0.1
Arm fat percentage (right)	0.0	0.1	0.3	-0.5	-0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.2	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.2	-0.0
Body fat percentage	0.0	0.1	0.2	-0.2	0.4
Migraine (self-reported)	0.0	0.0	0.0	-0.2	0.0
Arm fat percentage (left)	0.0	0.0	0.0	-0.2	-0.1
Average weekly red wine intake	0.0	0.0	0.0	0.1	0.1
Leg fat percentage (left)	0.0	0.0	0.1	-0.1	0.3
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.2	-0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	-0.3
Alcohol drinker status: Previous	0.0	0.0	0.1	0.2	0.2

Hub : Genes

CISD3

Models

Trait associations