Hub : Genes

CISD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pituitary 0.486 0.115 0.00063 0.081 NA 0.097 NA 0.121 4.5e-03 NA 0.0020 NA 0.0006
2 TCGA Ovarian Serous Cystadenocarcinoma 0.106 0.048 0.00066 0.063 0.035 0.024 NA 0.031 4.8e-05 0.0019 0.0088 NA 0.0035

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.6 -0.4 -0.8
Bipolar Disorder or Schizophrenia 0.5 1.1 2.2 -0.2 -1.5
Depressed Affect (Nagel 2018) 1.8 3.7 6.8 -0.8 -2.6
Depression (Nagel 2018) 4.3 6.5 11.2 -3.3 -1.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 0.9 0.7 0.9
Neuroticism (Nagel 2018) 1.6 3.7 7.2 0.3 -2.7
Schizophrenia (2018) 0.6 1.2 2.3 0.2 -1.5
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.4 0.4
Worry (Nagel 2018) 1.5 3.2 6.0 0.6 -2.4
Alzheimer’s Disease (in mother) 1.6 1.9 3.8 0.2 1.9
Alzheimer’s Disease (in father) 1.5 1.7 2.3 1.0 -1.5
Alzheimer’s Disease (including proxy) 0.5 0.8 1.0 1.0 0.7
Crohns Disease (2017) 0.2 0.4 0.7 -0.1 0.9
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.2 0.3
Ulcerative Colitis (UC) 0.1 0.1 0.3 0.2 -0.5
Major Depression (MDD) 1.5 1.8 3.4 -1.8 -0.5
Reaction Time 0.1 0.2 0.4 0.1 0.6
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.9 1.7 0.5
Breast Cancer 1.5 3.6 5.4 1.3 -2.3
Ovarian Cancer 1.2 1.5 1.9 -1.4 -1.1
Prostate Cancer 1.6 2.2 4.3 -2.1 0.3
Age at First Birth 1.1 1.6 3.0 1.7 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 2.2 -1.5 0.1
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.1 0.4
Crohns Disease (2012) 0.5 0.8 0.9 -0.8 1.0
Mean Putamen Volume 0.2 0.2 0.3 -0.5 0.3
Fasting Glucose 0.4 0.4 0.7 0.9 0.3
HbA1C 0.2 0.2 0.2 0.4 -0.5
HDL Cholesterol 0.7 1.2 2.3 1.5 -0.1
LDL Cholesterol 0.5 0.8 1.5 0.3 1.2
Lupus 0.2 0.3 0.6 0.8 -0.0
Neuroticism (2016) 4.2 6.0 11.6 0.7 -3.4
Primary Biliary Cirrhosis 6.1 8.8 17.5 -0.3 4.2
Rheumatoid Arthritis 0.9 1.3 2.3 0.6 1.5
Schizophrenia (2014) 0.3 0.7 1.5 -0.0 -1.2
Triglycerides 1.3 2.0 3.0 -1.7 1.1
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.1 -0.1 -1.0
Ulcerative Colitis 0.2 0.2 0.4 -0.6 -0.2
Blood Eosinophil Count 0.9 7.1 14.1 -0.3 -3.8
Blood Platelet Count 0.7 8.2 16.5 -0.1 -4.1
Blood Red Count 0.0 0.4 0.4 0.6 0.6
Blood White Count 0.8 6.2 12.2 0.5 -3.5
Heel T-Score 2.2 17.7 27.2 2.9 5.2
BMI 0.3 2.0 3.3 -1.8 0.9
Height 0.2 3.1 6.0 -2.4 -0.4
Waist Hip Ratio (WHR) 0.1 0.4 0.5 -0.7 -0.6
Systolic Blood Pressure 0.1 0.6 0.9 0.5 -0.9
Smoking Status 1.9 4.5 6.6 -1.5 2.6
Allergy or Eczema 1.8 4.8 8.8 -0.9 -3.0
Cardiovascular Disease 0.7 2.4 4.4 -0.6 -2.1
Hypothyroidism (self reported) 0.0 0.1 0.1 -0.2 -0.4
Respiratory disease 2.2 5.0 9.9 0.3 -3.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 0.6 -0.3
Lung FEV1/FVC ratio 10.1 51.1 102.0 -0.5 10.1
Lung FVC 0.5 2.7 5.0 0.7 2.2
Neuroticism 2.4 5.8 9.9 -1.3 -3.1
Chronotype (morning person) 1.2 2.9 5.7 0.1 2.4
Hair Pigment 0.2 4.9 6.0 2.0 2.5
Tanning 0.1 0.8 1.5 -1.2 0.3
Hand grip strength (left) 1.6 4.2 5.6 -1.7 2.4
Number of treatments/medications taken 1.8 3.2 6.3 -0.4 -2.5
Average weekly spirits intake 0.3 0.3 0.6 0.8 -0.2
Sensitivity / hurt feelings 1.7 2.9 3.3 -1.6 -1.8
Frequency of depressed mood in last 2 weeks 3.7 5.2 6.7 -2.6 -2.0
Hearing difficulty/problems: Yes 1.2 1.8 3.4 0.5 -1.8
Relative age of first facial hair 0.1 0.2 0.4 0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.6 -2.1 -0.3
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.1 0.6
Ever had hysterectomy (womb removed) 0.6 0.7 1.0 0.6 1.0
Systolic blood pressure, automated reading 0.2 0.5 1.0 1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.0 -0.4
Angina 0.8 1.1 2.1 0.1 -1.5
Medication for hormone replacement therapy 0.4 0.5 0.7 0.5 0.8
Vitamin and mineral supplements 1.8 2.5 3.0 1.4 1.7
Supplements: Zinc 2.2 2.4 4.5 -2.1 -0.6
Medication: Co-codamol 2.2 2.5 5.0 -2.2 0.2
Medication: Metformin 0.8 1.1 1.9 0.5 1.4
Diabetes (father) 1.1 1.4 2.3 -1.5 -0.7
Diabetes (mother) 0.3 0.4 0.5 0.7 -0.5
Severe depression (siblings) 1.5 1.7 3.2 -0.5 -1.8
Pack years adult smoking proportion 0.6 1.0 1.7 0.5 -1.3
Impedance of leg (right) 0.6 3.0 6.0 2.5 0.2
Leg fat-free mass (left) 1.2 6.4 12.7 -3.6 -0.2
Trunk fat percentage 0.0 0.1 0.3 0.2 0.5
Hand grip strength (right) 1.6 4.5 8.9 -0.2 3.0
Townsend deprivation index at recruitment 0.9 1.2 2.4 0.1 -1.5
Current tobacco smoking 0.2 0.4 0.7 -0.2 -0.8
Average weekly fortified wine intake 0.2 0.3 0.5 -0.3 0.7
Maternal smoking around birth 0.3 0.4 0.9 0.9 0.1
Fed-up feelings 3.3 6.0 7.1 -2.2 -2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 3.9 -1.4 -2.0
Relative age voice broke 0.0 0.0 0.0 0.1 -0.2
Taking other prescription medications 0.6 1.0 1.4 0.7 -1.2
Age when periods started (menarche) 2.3 5.4 8.3 1.6 2.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.2 -0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 3.6 1.7 1.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.2 0.2 -1.1
Qualifications: CSEs or equivalent 0.3 0.4 0.5 0.7 -0.6
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.1 0.4
High blood pressure 0.9 2.6 4.6 -0.8 -2.1
Hayfever, allergic rhinitis or eczema 3.2 7.0 12.7 -1.1 -3.6
Multivitamins +/- minerals 1.0 1.2 1.9 -0.7 -1.4
Stomach or abdominal pain in last month 1.5 1.8 3.6 0.1 -1.9
Supplements: Glucosamine 2.2 2.8 5.5 -0.3 2.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 0.9 -0.7 1.0
Medication: Atenolol 3.0 3.7 5.9 -1.2 -2.4
Medication: Levothyroxine sodium 0.6 1.0 1.6 1.3 0.7
Sitting height 0.7 5.2 9.2 -3.0 1.1
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 0.1 -0.8
High blood pressure (mother) 0.7 1.0 1.7 -0.4 -1.3
Body mass index (BMI) 0.3 1.3 2.5 -1.6 0.3
Impedance of leg (left) 1.2 6.0 11.6 3.4 0.5
Leg predicted mass (left) 1.2 6.5 13.0 -3.6 -0.2
Trunk fat mass 0.2 0.8 1.3 -1.2 0.4
Waist circumference 0.3 1.1 2.0 -1.4 -0.5
Number of incorrect matches in round 1.8 3.0 5.8 -2.4 0.5
Past tobacco smoking 2.2 3.9 4.4 2.1 -1.9
Alcohol usually taken with meals 0.3 0.5 0.9 -0.1 1.0
Nervous feelings 2.1 4.0 7.9 -0.3 -2.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.2 0.1 -1.8
Hearing difficulty/problems with background noise 0.0 0.0 0.0 -0.1 -0.1
Hair/balding pattern: Pattern 2 1.2 1.6 2.3 -0.9 1.5
Had menopause 0.0 0.0 0.0 0.0 -0.2
Had other major operations 0.3 0.4 0.8 -0.9 -0.1
Forced vital capacity (FVC) 0.6 2.3 4.5 -0.4 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.8 6.3 1.1 2.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.4 0.0
Qualifications: None of the above 0.2 0.4 0.7 0.3 -0.9
Financial difficulties in last 2 years 0.5 0.7 1.4 1.2 0.3
Mouth/teeth dental problems 1.5 2.3 4.5 0.4 2.1
Heart attack 0.0 0.0 0.0 -0.2 -0.1
Allergy 2.9 6.6 12.5 0.8 3.5
Pain all over the body in last month 0.3 0.4 0.6 0.3 -0.8
Diabetes (self-reported) 0.1 0.1 0.2 0.3 -0.4
Hayfever/allergic rhinitis (self-reported) 2.0 2.7 5.3 -0.2 -2.3
Medication: Ramipril 1.0 1.3 1.7 -1.0 -1.3
Medication: Simvastatin 0.2 0.3 0.6 -0.1 -0.8
Fluid intelligence score 0.1 0.3 0.3 0.5 0.6
Illnesses of siblings 1.5 2.2 4.1 -0.5 2.0
Neuroticism score 2.4 4.9 9.1 -0.9 -3.0
Weight 0.8 4.0 8.1 -2.8 0.2
Impedance of arm (right) 0.9 4.2 8.1 2.8 -0.6
Arm fat percentage (right) 0.0 0.1 0.3 -0.5 -0.0
Trunk fat-free mass 1.8 10.5 21.0 -4.6 -0.2
Hip circumference 0.2 1.0 1.7 -1.3 -0.6
Time employed in main current job 1.8 2.0 3.6 -1.9 -0.7
Alcohol intake versus 10 years previously 0.0 0.0 0.1 -0.2 -0.1
Father’s age at death 1.7 2.3 4.5 0.1 2.1
Worrier / anxious feelings 0.3 0.6 0.7 0.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 3.0 4.9 5.4 -2.3 -2.1
Falls in the last year 0.3 0.4 0.7 -0.1 -0.9
Hair/balding pattern: Pattern 3 0.9 1.4 1.8 -1.0 -1.3
Number of live births 0.4 0.5 1.0 0.1 1.0
Forced expiratory volume in 1-second (FEV1) 3.3 11.1 22.3 -0.1 4.7
Pulse rate 0.8 1.3 2.7 0.1 -1.6
Happiness 2.9 3.6 5.9 -1.1 -2.4
Noisy workplace 0.5 0.6 1.0 0.3 -1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.7 0.4 -1.3
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.0 -0.1 1.7
Mouth/teeth dental problems: Dentures 0.2 0.3 0.4 -0.5 -0.6
Asthma 1.5 3.0 5.7 0.4 -2.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.4 1.2 0.5
Medication: Cholesterol lowering 0.0 0.0 0.0 0.2 -0.2
Depression (self-reported) 1.0 1.3 1.3 -1.1 -1.1
Medication: Lansoprazole 1.6 1.8 2.5 -1.6 1.1
Prospective memory result 0.1 0.1 0.2 0.4 0.4
Lung cancer (father) 0.3 0.4 0.5 -0.5 0.7
Illnesses of mother 2.3 2.8 4.7 -1.0 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 10.0 19.2 -0.9 4.4
Pulse wave Arterial Stiffness index 0.7 0.8 1.1 -0.7 -1.0
Impedance of arm (left) 1.5 6.7 13.3 3.6 -0.4
Arm fat mass (right) 0.3 1.4 2.7 -1.6 0.0
Trunk predicted mass 1.8 10.4 20.8 -4.6 -0.3
Standing height 0.5 4.8 9.7 -3.1 0.0
Length of working week for main job 2.2 2.4 2.5 1.6 1.5
Exposure to tobacco smoke at home 2.8 3.2 6.3 0.3 -2.5
Breastfed as a baby 0.4 0.5 0.8 0.4 -0.9
Tense / ‘highly strung’ 0.5 0.8 1.6 -0.0 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 4.9 7.5 11.9 -3.5 -1.8
Hair/balding pattern: Pattern 4 2.8 6.7 11.0 3.3 -1.6
Birth weight of first child 1.2 2.1 4.1 -2.0 -0.3
Peak expiratory flow (PEF) 6.4 14.8 29.1 0.8 5.4
Pulse wave reflection index 0.6 0.7 1.4 -0.2 1.2
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.4 -0.7 -0.6
Loud music exposure frequency 0.7 0.8 1.6 -1.3 0.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.6 -0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.2 -0.4 -0.5
Blood clot in the leg (DVT) 1.0 1.3 2.1 -0.7 1.5
Medication: Paracetamol 0.1 0.1 0.3 0.2 -0.5
Headache pain in last month 0.1 0.1 0.3 0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 -0.0 0.5
Glaucoma (self-reported) 3.7 4.4 8.4 2.9 0.5
Gout (self-reported) 0.9 1.2 1.6 -0.9 1.2
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 0.2 -0.0
Medication: Amlodipine 0.1 0.1 0.2 0.2 -0.5
Medication: Ventolin 100micrograms inhaler 4.3 5.5 8.2 1.7 -2.9
Birth weight 0.5 1.2 2.4 -1.5 -0.1
Chronic bronchitis/emphysema (mother) 2.8 3.2 5.0 -1.2 -2.2
High blood pressure (siblings) 0.1 0.1 0.2 -0.4 -0.1
Forced vital capacity (FVC), Best measure 0.5 1.9 3.0 -0.9 1.7
Body fat percentage 0.0 0.1 0.2 -0.2 0.4
Leg fat percentage (right) 0.1 0.2 0.4 -0.6 0.1
Arm fat-free mass (right) 1.3 6.7 13.2 -3.6 0.4
Exposure to tobacco smoke outside home 0.1 0.2 0.4 0.2 -0.6
Comparative body size at age 10 0.5 1.3 2.6 0.2 1.6
Number of full brothers 1.9 2.4 4.7 2.2 0.2
Worry too long after embarrassment 1.2 2.0 3.1 1.0 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 4.7 -2.2 -1.2
Wheeze or whistling in the chest in last year 2.5 4.5 7.8 -1.1 -2.8
Number of children fathered 2.1 2.4 2.8 -1.4 1.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 -0.1 0.6
Age at first live birth 0.1 0.3 0.5 -0.7 0.1
Pulse wave peak to peak time 0.5 0.6 1.0 0.5 1.0
Health satisfaction 2.3 3.0 5.3 -0.8 -2.3
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.6 -0.2
Qualifications: College or University degree 0.3 0.9 1.4 -1.2 0.7
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.2 0.6
Mouth/teeth dental problems: Loose teeth 1.3 1.5 3.0 -1.7 -0.4
Emphysema/chronic bronchitis 1.2 1.3 1.7 -1.3 -1.0
Medication for pain relief, constipation, heartburn 0.5 0.8 1.4 0.4 1.2
Neck or shoulder pain in last month 2.2 3.1 6.2 0.0 -2.5
Medication: Blood pressure 0.3 0.5 0.8 -0.4 -0.9
Angina (self-reported) 1.0 1.3 2.6 -0.2 -1.6
Migraine (self-reported) 0.0 0.0 0.0 -0.2 0.0
Medication: Ibuprofen 0.8 1.0 1.0 1.0 1.0
Medication: Allopurinol 0.8 1.1 1.3 -1.1 1.0
Medication: Omeprazole 1.4 1.7 3.3 -1.8 -0.0
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.6 0.2
Mean time to correctly identify matches 0.6 1.2 2.0 0.6 1.4
Heart disease (mother) 4.2 5.1 9.9 0.6 -3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.5 -0.3 1.2
Whole body fat mass 0.3 1.3 2.4 -1.5 0.4
Leg fat mass (right) 0.5 1.8 3.6 -1.9 0.2
Arm predicted mass (right) 1.3 6.6 13.1 -3.6 0.1
Pulse rate, automated reading 5.0 16.2 32.3 0.2 -5.7
Alcohol intake frequency. 0.7 1.7 3.1 0.5 -1.8
Comparative height size at age 10 0.6 3.5 6.6 -2.6 -0.6
Number of full sisters 0.8 1.0 1.9 -1.4 0.3
Suffer from ‘nerves’ 1.4 2.2 4.5 0.1 -2.1
Overall health rating 3.3 7.1 13.2 -1.0 -3.6
Chest pain or discomfort 1.8 2.6 2.8 -1.5 -1.7
Had major operations 1.8 2.1 4.2 -2.0 -0.2
Age at last live birth 0.2 0.3 0.5 0.7 0.2
Family relationship satisfaction 2.1 2.6 4.3 -1.0 -2.1
Leg pain on walking 0.1 0.1 0.1 -0.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.5 0.1 -0.7
Commuting to job workplace: Car/motor vehicle 1.2 1.4 1.7 1.0 1.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.0 -0.3 -1.7
Medication: Aspirin 0.5 0.6 1.2 -0.3 -1.1
Supplements: Vitamin C 2.0 2.3 4.6 -2.1 -0.2
Knee pain experienced in last month 0.7 1.1 1.2 -1.1 1.0
Hypertension (Self-reported) 1.2 3.3 5.5 -1.1 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.4 0.4 -0.6
Illnesses of father: Heart disease 0.4 0.6 1.0 0.4 -1.0
Illnesses of siblings: Diabetes 1.8 2.2 2.7 1.6 -1.3
Smoking status: Previous 4.7 7.0 10.6 -1.8 3.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.9 -0.3 0.9
Whole body fat-free mass 1.6 9.2 18.4 -4.3 0.0
Leg fat-free mass (right) 0.9 4.9 9.9 -3.1 -0.1
Arm fat percentage (left) 0.0 0.0 0.0 -0.2 -0.1
Average weekly red wine intake 0.0 0.0 0.0 0.1 0.1
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.7 -1.3 -0.0
Mood swings 0.9 1.7 2.1 -1.2 -1.4
Loneliness, isolation 2.5 3.4 6.6 -0.5 -2.6
Long-standing illness, disability or infirmity 1.0 1.6 1.9 -1.1 -1.4
Ever had bowel cancer screening 0.1 0.1 0.2 0.2 0.5
Diabetes diagnosed by doctor 0.1 0.2 0.2 0.3 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.3 2.7 -1.6 0.2
Friendships satisfaction 2.8 3.4 6.2 -0.8 -2.5
Qualifications: nursing, teaching 1.5 2.3 2.9 -1.3 1.7
Commuting to job workplace: Walk 0.6 0.6 0.7 -0.8 -0.8
Eye problems/disorders: Cataract 0.3 0.3 0.5 -0.7 0.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 2.6 1.6 -1.3
Medication for cholesterol 1.1 1.6 3.2 -0.3 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 0.8 -0.9 -0.8
Back pain experienced in last month 0.5 0.7 1.3 -0.4 1.2
Mineral and other dietary supplements 0.1 0.1 0.2 0.4 0.3
Breast cancer (self-reported) 0.4 0.5 1.0 -1.0 0.3
Asthma (self-reported) 1.7 3.3 6.5 0.4 -2.5
Osteoporosis (self-reported) 2.4 3.0 5.9 -0.2 -2.4
Osteoarthritis (self-reported) 0.4 0.6 0.9 -0.5 1.0
Medication: Aspirin 0.2 0.2 0.4 -0.2 -0.7
Medication: Gliclazide 0.2 0.2 0.2 0.5 -0.4
Illnesses of father: None of the above (group 1) 2.2 2.7 4.3 1.0 2.1
Smoking status: Current 0.6 1.0 1.5 -0.7 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.1 10.8 21.5 0.3 4.6
Whole body water mass 1.6 8.9 17.7 -4.2 -0.0
Leg predicted mass (right) 1.0 5.3 10.5 -3.2 -0.3
Arm fat mass (left) 0.3 1.1 2.2 -1.5 0.2
Number of self-reported non-cancer illnesses 1.1 1.9 3.1 -0.8 -1.8
Average weekly champagne plus white wine intake 0.4 0.6 1.0 -1.0 0.4
Miserableness 0.7 1.2 1.7 -1.3 -0.9
Guilty feelings 0.4 0.6 1.1 -0.0 -1.1
Wears glasses or contact lenses 1.4 1.6 3.2 1.8 -0.2
Ever taken oral contraceptive pill 1.2 1.3 1.7 -1.0 1.3
Hearing aid user 0.3 0.3 0.4 -0.6 0.6
Mother’s age at death 1.2 1.5 2.5 0.7 1.6
Financial situation satisfaction 2.9 3.5 7.0 -0.4 -2.6
Tinnitus: Yes, now most or all of the time 2.7 3.2 4.6 2.1 1.3
Commuting to job workplace: Public transport 0.8 1.0 1.4 -1.2 -0.7
Eye problems/disorders: Glaucoma 2.2 2.6 5.0 2.2 0.5
Medication: Blood pressure 1.9 3.6 6.3 -0.9 -2.5
Pain type(s) experienced in last month: Hip pain 1.0 1.2 1.6 -0.9 -1.3
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.0 -0.5 -1.0
High cholesterol (Self-reported) 0.4 0.7 1.3 -0.2 -1.1
Medication: Bendroflumethiazide 1.4 2.1 4.2 -0.3 -2.0
Medication: Paracetamol 0.1 0.1 0.2 0.2 -0.4
Medication: Lisinopril 0.1 0.2 0.3 0.2 -0.5
Medication: Atorvastatin 0.5 0.6 1.1 1.1 -0.3
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.6 0.3
Alcohol drinker status: Never 1.9 2.3 3.3 1.8 1.1
Ever smoked 0.5 0.8 1.0 -1.0 0.8
Basal metabolic rate 1.3 7.5 14.9 -3.9 -0.0
Leg fat percentage (left) 0.0 0.0 0.1 -0.1 0.3
Arm fat-free mass (left) 1.5 7.5 15.1 -3.9 -0.0
Number of operations (self-reported) 2.2 3.3 5.6 -2.4 -1.0
Average weekly beer plus cider intake 1.8 2.6 4.6 0.8 -2.1
Irritability 1.3 2.3 4.6 -0.1 -2.1
Risk taking 1.6 2.3 4.0 0.8 2.0
Ever had prostate specific antigen (PSA) test 1.7 1.9 3.3 -1.8 -0.7
Fractured/broken bones in last 5 years 2.9 3.7 4.1 -1.8 -2.0
Age started oral contraceptive pill 0.1 0.1 0.1 0.1 0.4
Diastolic blood pressure, automated reading 0.3 0.9 1.4 0.6 -1.2
Ever depressed for a whole week 1.3 1.5 1.7 -1.2 1.3
Unable to work because of sickness or disability 0.7 0.9 1.6 0.4 -1.3
Commuting to job workplace: Cycle 1.3 1.5 3.0 -0.3 -1.7
Myopia 1.6 2.3 2.6 1.4 -1.6
Vascular/heart problems diagnosed by doctor 0.8 2.1 4.2 0.2 2.0
Cholesterol lowering medication 1.2 1.8 3.5 0.3 -1.9
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.6 -1.6 0.4
Pain experienced in last month 0.2 0.4 0.7 -0.8 0.3
Supplements: Calcium 3.1 3.4 4.4 -1.6 -2.1
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 -0.2 -0.0
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 -0.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 2.7 -0.8 1.6
Heart disease (siblings) 0.6 0.8 1.5 1.2 -0.3
Alcohol drinker status: Previous 0.0 0.0 0.1 0.2 0.2
Pack years of smoking 0.6 1.0 1.7 0.4 -1.3
Impedance of whole body 1.7 8.5 16.9 4.1 0.4
Leg fat mass (left) 0.3 1.3 2.5 -1.6 0.3
Arm predicted mass (left) 1.3 6.5 13.0 -3.6 -0.1