[Hub]/) : Traits : Heel T-Score : ← →

chr19:260,912-4,821,612

Best TWAS P=1.18e-22 · Best GWAS P=1.63e-67 conditioned to 2.66e-39

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PALM	0.08	0.00	blup	481	0.02	1.6e-03	-0.33	7.1	1.1e-12	-0.28	0.04	0.23	TRUE
2	GTEx	Adipose Subcutaneous	SGTA	0.13	0.05	lasso	5	0.07	4.6e-06	-5.12	5.4	6.6e-08	0.08	0.87	0.01	FALSE
3	GTEx	Artery Aorta	PIAS4	0.23	0.02	lasso	5	0.05	1.3e-03	-6.39	-6.0	2.1e-09	-0.01	0.04	0.61	TRUE
4	GTEx	Artery Aorta	ZNF554	0.34	0.21	lasso	6	0.19	6.3e-11	-5.09	-5.2	2.6e-07	-0.11	1.00	0.00	FALSE
5	GTEx	Artery Tibial	DOT1L	0.09	0.06	lasso	5	0.05	7.3e-05	-9.31	-8.1	4.6e-16	-0.01	0.76	0.01	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	ZNF554	0.26	0.27	lasso	4	0.24	2.7e-08	-5.26	-5.4	7.4e-08	-0.12	0.93	0.01	FALSE
7	GTEx	Cells Transformed fibroblasts	ZNF554	0.25	0.24	lasso	3	0.23	1.9e-17	-5.09	-5.2	2.0e-07	-0.11	1.00	0.00	FALSE
8	GTEx	Colon Sigmoid	MAP2K2	0.20	0.11	lasso	3	0.13	3.0e-05	5.67	6.4	1.8e-10	-0.02	0.02	0.85	TRUE
9	GTEx	Colon Transverse	THOP1	0.19	0.13	lasso	4	0.15	1.7e-07	-5.30	-5.2	1.5e-07	-0.13	0.93	0.00	FALSE
10	GTEx	Esophagus Muscularis	DOT1L	0.12	0.03	lasso	5	0.05	6.3e-04	-9.31	-5.6	1.9e-08	-0.02	0.40	0.03	TRUE
11	GTEx	Heart Left Ventricle	THOP1	0.17	0.09	lasso	2	0.02	2.2e-02	-5.30	-5.2	1.5e-07	-0.14	0.62	0.03	FALSE
12	GTEx	Lung	ZNF554	0.27	0.10	lasso	7	0.09	1.8e-07	-5.12	-5.6	2.7e-08	-0.12	0.99	0.00	FALSE
13	GTEx	Nerve Tibial	IZUMO4	0.23	0.07	lasso	6	0.14	1.9e-10	1.37	5.3	9.8e-08	-0.03	0.97	0.01	FALSE
14	GTEx	Ovary	SGTA	0.43	-0.01	enet	47	0.02	9.8e-02	-5.10	6.0	2.4e-09	-0.01	0.04	0.35	FALSE
15	GTEx	Pancreas	ZNF554	0.23	0.06	lasso	2	0.06	2.3e-03	-5.30	-5.2	1.5e-07	-0.13	0.37	0.03	FALSE
16	GTEx	Skin Sun Exposed Lower leg	AC004490.1	0.09	0.07	enet	11	0.10	2.3e-08	5.24	-5.5	3.0e-08	0.04	0.92	0.01	FALSE
17	GTEx	Testis	ZNF554	0.19	0.11	lasso	3	0.07	5.9e-04	-5.12	-5.2	2.3e-07	-0.11	0.38	0.04	FALSE
18	GTEx	Thyroid	POLR2E	0.22	0.16	lasso	1	0.15	2.4e-11	-5.58	-5.6	2.4e-08	0.49	1.00	0.00	FALSE
19	GTEx	Thyroid	ZNF554	0.14	0.07	lasso	3	0.05	4.8e-05	-5.12	-5.2	1.6e-07	-0.11	0.82	0.01	FALSE
20	GTEx	Thyroid	THOP1	0.34	0.24	lasso	5	0.32	5.9e-25	-5.26	-5.4	6.5e-08	-0.12	1.00	0.00	FALSE
21	GTEx	Whole Blood	ZNF554	0.11	0.09	lasso	5	0.08	7.4e-08	-5.10	-5.2	2.0e-07	-0.11	1.00	0.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	TCF3	0.08	0.03	bslmm	368	0.02	7.4e-04	-4.69	6.8	1.0e-11	-0.08	0.71	0.06	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	PIAS4	0.14	0.12	lasso	6	0.11	1.6e-13	4.33	5.1	2.8e-07	0.00	1.00	0.00	FALSE
24	YFS	Blood	STK11	0.08	0.06	enet	12	0.07	4.6e-21	5.87	-6.3	2.4e-10	0.16	1.00	0.00	TRUE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3D1	0.05	0.00	blup	49	0.02	1.7e-02	1.96	-5.2	2.4e-07	0.08	0.03	0.22	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SBNO2	0.08	0.00	blup	63	0.02	1.4e-02	-1.17	9.4	3.7e-21	-0.42	0.03	0.32	TRUE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF554	0.11	0.16	lasso	3	0.16	1.9e-13	-5.44	-5.4	7.8e-08	-0.13	0.01	0.98	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3D1	0.01	0.01	blup	52	0.01	5.4e-03	1.96	-6.3	2.9e-10	0.03	0.04	0.33	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF554	0.12	0.12	lasso	3	0.13	4.5e-07	-5.12	-5.3	1.4e-07	-0.10	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF554	0.16	0.18	lasso	5	0.18	6.8e-11	-5.37	-5.4	5.7e-08	-0.13	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	CFD	0.24	0.09	blup	48	0.12	1.3e-04	1.81	5.7	1.0e-08	-0.02	0.10	0.13	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF554	0.15	0.20	lasso	7	0.20	5.0e-22	-5.03	-5.1	2.8e-07	-0.11	0.02	0.97	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOT1L	0.08	0.12	enet	8	0.10	2.5e-11	-9.31	-9.8	1.2e-22	-0.01	0.03	0.97	TRUE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MED16	0.07	0.01	blup	58	0.02	5.3e-03	4.06	5.1	2.8e-07	-0.04	0.04	0.12	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THOP1	0.04	0.05	blup	65	0.04	2.3e-05	-5.09	-6.0	1.5e-09	-0.11	0.02	0.98	TRUE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF554	0.05	0.06	lasso	5	0.06	2.8e-07	-5.27	-5.2	1.6e-07	-0.11	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DOT1L	0.09	0.08	blup	60	0.07	4.1e-04	7.93	-8.7	3.8e-18	-0.01	0.08	0.82	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	CFD	0.04	0.03	lasso	6	0.04	1.6e-05	2.13	6.0	1.5e-09	0.01	0.09	0.79	TRUE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF554	0.04	0.04	blup	55	0.03	4.4e-04	-5.12	-5.5	3.7e-08	-0.12	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF554	0.04	0.05	lasso	2	0.05	7.9e-07	-5.37	-5.4	8.0e-08	-0.14	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CFD	0.06	0.04	blup	48	0.04	7.2e-04	1.81	5.4	5.3e-08	-0.01	0.25	0.11	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF554	0.07	0.09	lasso	15	0.10	3.7e-05	-5.37	-5.4	5.4e-08	-0.13	0.01	0.97	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF554	0.11	0.15	lasso	4	0.14	1.5e-10	-5.10	-5.2	1.5e-07	-0.12	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DOT1L	0.40	-0.01	enet	20	0.03	3.6e-02	3.25	-5.3	1.1e-07	-0.02	0.01	0.23	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	SBNO2	0.07	0.00	blup	63	0.02	1.1e-02	-0.72	6.2	5.3e-10	-0.15	0.02	0.07	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	THOP1	0.16	0.25	lasso	2	0.25	1.6e-24	-5.19	-5.2	2.3e-07	-0.12	0.02	0.98	FALSE