[Hub]/) : Traits : Heel T-Score : ← →

chr19:43,298,356-45,050,756

Best TWAS P=1.52e-11 · Best GWAS P=4.02e-09 conditioned to 0.0941

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ETHE1	0.18	0.16	lasso	6	0.19	1.0e-15	5.6	-6.8	1.5e-11	-0.88	0.01	0.99	TRUE
2	GTEx	Adipose Subcutaneous	PINLYP	0.25	0.06	lasso	5	0.12	5.0e-10	-4.6	6.0	1.5e-09	0.57	0.53	0.45	FALSE
3	GTEx	Artery Aorta	ETHE1	0.20	0.12	lasso	6	0.14	4.9e-08	5.7	-6.1	8.5e-10	-0.88	0.02	0.98	FALSE
4	GTEx	Artery Aorta	PINLYP	0.29	0.10	lasso	8	0.15	8.6e-09	5.3	6.1	9.9e-10	0.71	0.07	0.92	FALSE
5	GTEx	Artery Tibial	ETHE1	0.21	0.06	enet	19	0.14	2.9e-11	-4.8	-6.6	3.9e-11	-0.73	0.13	0.86	FALSE
6	GTEx	Artery Tibial	PINLYP	0.26	0.23	lasso	6	0.25	2.1e-19	5.3	5.8	7.3e-09	0.77	0.07	0.93	FALSE
7	GTEx	Brain Putamen basal ganglia	PINLYP	0.46	0.14	lasso	7	0.25	1.0e-06	4.9	6.1	1.4e-09	0.74	0.10	0.76	FALSE
8	GTEx	Breast Mammary Tissue	PINLYP	0.20	0.06	lasso	8	0.11	2.9e-06	4.8	5.7	1.0e-08	0.72	0.06	0.92	FALSE
9	GTEx	Breast Mammary Tissue (Male)	PINLYP	0.34	0.06	enet	2	0.07	1.0e-02	5.7	5.8	5.5e-09	0.97	0.02	0.86	FALSE
10	GTEx	Cells Transformed fibroblasts	ETHE1	0.31	0.26	enet	19	0.35	3.4e-27	-4.2	-5.7	9.8e-09	-0.54	0.62	0.38	FALSE
11	GTEx	Cells Transformed fibroblasts	PINLYP	0.29	0.13	lasso	5	0.21	5.1e-16	4.9	5.4	5.7e-08	0.76	0.24	0.76	FALSE
12	GTEx	Colon Sigmoid	PINLYP	0.39	0.13	lasso	11	0.24	6.5e-09	-4.6	5.3	1.4e-07	0.46	0.54	0.33	FALSE
13	GTEx	Colon Transverse	PINLYP	0.21	0.01	enet	19	0.06	1.1e-03	4.9	5.3	1.0e-07	0.68	0.04	0.92	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	PINLYP	0.25	0.04	lasso	5	0.13	1.8e-05	4.8	6.0	1.7e-09	0.72	0.14	0.70	FALSE
15	GTEx	Esophagus Mucosa	ETHE1	0.21	0.10	lasso	4	0.08	5.6e-06	5.7	-5.7	1.5e-08	-0.94	0.01	0.99	FALSE
16	GTEx	Esophagus Muscularis	ETHE1	0.09	0.12	lasso	2	0.09	2.9e-06	5.7	-5.5	2.8e-08	-0.92	0.01	0.99	FALSE
17	GTEx	Esophagus Muscularis	PINLYP	0.20	0.12	lasso	9	0.14	4.7e-09	4.8	5.9	2.8e-09	0.80	0.17	0.83	FALSE
18	GTEx	Heart Atrial Appendage	PINLYP	0.22	0.00	enet	43	0.06	7.3e-04	4.9	5.4	6.5e-08	0.35	0.08	0.31	FALSE
19	GTEx	Liver	ETHE1	0.21	0.19	lasso	3	0.16	2.4e-05	5.7	-5.5	4.3e-08	-0.92	0.04	0.91	FALSE
20	GTEx	Lung	PINLYP	0.24	0.13	enet	27	0.19	1.7e-14	-3.9	5.3	1.4e-07	0.46	0.72	0.27	FALSE
21	GTEx	Muscle Skeletal	ETHE1	0.06	0.06	lasso	2	0.03	2.9e-04	5.7	-5.7	1.4e-08	-0.93	0.01	0.98	FALSE
22	GTEx	Muscle Skeletal	PINLYP	0.10	0.00	enet	13	0.02	7.3e-03	4.9	5.8	8.7e-09	0.77	0.06	0.89	FALSE
23	GTEx	Nerve Tibial	ETHE1	0.09	0.05	enet	11	0.08	3.1e-06	5.7	-5.3	9.3e-08	-0.69	0.02	0.96	FALSE
24	GTEx	Nerve Tibial	PINLYP	0.33	0.12	lasso	4	0.26	4.0e-18	-4.6	5.3	9.2e-08	0.44	0.67	0.33	FALSE
25	GTEx	Ovary	PINLYP	0.36	0.25	lasso	6	0.31	1.8e-08	-4.6	5.2	1.6e-07	0.38	0.38	0.31	FALSE
26	GTEx	Pancreas	ETHE1	0.33	0.19	enet	20	0.22	1.3e-09	5.7	-6.5	6.0e-11	-0.86	0.01	0.99	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	ETHE1	0.13	0.06	lasso	3	0.05	1.0e-03	5.7	-5.6	1.7e-08	-0.93	0.02	0.94	FALSE
28	GTEx	Skin Sun Exposed Lower leg	XRCC1	0.07	0.01	lasso	1	0.00	3.8e-01	5.9	-5.9	4.0e-09	-1.00	0.01	0.81	FALSE
29	GTEx	Thyroid	ZNF283	0.16	0.04	enet	17	0.08	1.2e-06	5.7	-5.7	1.6e-08	-0.13	0.01	0.99	TRUE
30	GTEx	Thyroid	PHLDB3	0.15	0.04	enet	12	0.06	3.7e-05	5.6	-5.5	3.9e-08	-0.71	0.02	0.97	FALSE
31	GTEx	Thyroid	PINLYP	0.14	0.08	lasso	6	0.11	6.1e-09	5.3	6.1	9.9e-10	0.76	0.15	0.84	FALSE
32	GTEx	Whole Blood	XRCC1	0.09	0.07	enet	16	0.07	4.6e-07	5.3	-5.4	6.9e-08	-0.69	0.06	0.92	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHLDB3	0.09	0.08	lasso	3	0.08	1.6e-16	5.7	-5.5	4.0e-08	-0.87	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Esophageal Carcinoma	XRCC1	0.14	0.01	blup	76	0.02	8.3e-02	-3.9	-6.2	5.9e-10	-0.51	0.03	0.16	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ETHE1	0.09	0.08	blup	69	0.09	3.3e-10	5.6	-6.2	5.2e-10	-0.80	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF283	0.08	0.05	lasso	4	0.03	1.2e-02	5.7	-5.5	5.1e-08	-0.12	0.00	0.91	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	ETHE1	0.12	0.11	enet	10	0.12	6.1e-14	5.7	-5.5	3.1e-08	-0.91	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ETHE1	0.08	0.08	enet	9	0.07	3.0e-04	5.7	-5.8	6.5e-09	-0.88	0.00	0.95	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	ETHE1	0.07	0.04	blup	68	0.04	1.9e-05	5.7	-5.8	4.9e-09	-0.86	0.00	0.99	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ETHE1	0.11	0.02	blup	69	0.08	4.2e-04	5.4	-6.6	5.5e-11	-0.79	0.01	0.90	FALSE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF575	0.17	0.13	blup	66	0.12	2.4e-05	-4.8	-6.2	7.9e-10	-0.46	0.27	0.47	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	ETHE1	0.11	0.14	lasso	7	0.14	2.3e-14	5.4	-5.3	1.1e-07	-0.93	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	ETHE1	0.14	0.03	blup	69	0.06	3.1e-04	4.9	-5.6	2.5e-08	-0.64	0.01	0.78	FALSE
44	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PHLDB3	0.18	0.06	blup	57	0.10	8.3e-04	-4.2	-5.9	4.6e-09	-0.71	0.02	0.78	FALSE