Best TWAS P=1.25e-18 · Best GWAS P=1.19e-22 conditioned to 0.496
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PRKD2 | 0.39 | 0.33 | enet | 13 | 0.41 | 4.3e-53 | 2.3 | -6.1 | 8.8e-10 | -0.07 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | FKRP | 0.31 | 0.33 | enet | 14 | 0.36 | 4.2e-31 | -5.4 | -5.8 | 6.9e-09 | -0.09 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | PPM1N | 0.11 | 0.09 | lasso | 5 | 0.08 | 2.4e-07 | 5.6 | 5.4 | 8.3e-08 | -0.32 | 0.99 | 0.00 | TRUE |
| 4 | GTEx | Adipose Visceral Omentum | FKRP | 0.31 | 0.11 | enet | 20 | 0.14 | 9.9e-08 | -5.4 | -7.5 | 4.5e-14 | -0.11 | 0.32 | 0.68 | FALSE |
| 5 | GTEx | Adrenal Gland | FKRP | 0.24 | 0.20 | lasso | 3 | 0.19 | 2.6e-07 | -5.5 | -5.6 | 2.6e-08 | -0.11 | 0.72 | 0.21 | FALSE |
| 6 | GTEx | Artery Aorta | PRKD2 | 0.15 | 0.11 | lasso | 2 | 0.08 | 5.8e-05 | -7.8 | -7.8 | 5.0e-15 | -0.02 | 0.02 | 0.97 | FALSE |
| 7 | GTEx | Artery Aorta | FKRP | 0.37 | 0.30 | lasso | 2 | 0.30 | 5.8e-17 | -5.1 | -5.9 | 4.2e-09 | -0.08 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Artery Coronary | PRKD2 | 0.27 | 0.04 | enet | 26 | 0.12 | 7.4e-05 | -8.4 | -5.3 | 1.1e-07 | -0.08 | 0.00 | 0.95 | FALSE |
| 9 | GTEx | Artery Coronary | FKRP | 0.26 | 0.26 | lasso | 1 | 0.24 | 8.2e-09 | -5.1 | -5.1 | 3.1e-07 | -0.08 | 0.74 | 0.12 | FALSE |
| 10 | GTEx | Artery Tibial | PRKD2 | 0.16 | 0.10 | lasso | 6 | 0.11 | 1.1e-08 | -8.1 | -8.8 | 1.3e-18 | -0.05 | 0.02 | 0.98 | TRUE |
| 11 | GTEx | Artery Tibial | FKRP | 0.37 | 0.34 | lasso | 3 | 0.36 | 1.7e-29 | -5.1 | -5.4 | 6.6e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Brain Cerebellar Hemisphere | FKRP | 0.38 | 0.14 | lasso | 7 | 0.22 | 2.7e-06 | -5.1 | -7.2 | 5.0e-13 | -0.06 | 0.01 | 0.98 | FALSE |
| 13 | GTEx | Brain Cortex | FKRP | 0.30 | 0.16 | lasso | 6 | 0.22 | 8.7e-07 | -5.4 | -5.5 | 2.8e-08 | -0.11 | 0.30 | 0.11 | FALSE |
| 14 | GTEx | Brain Hippocampus | FKRP | 0.34 | 0.07 | lasso | 5 | 0.14 | 4.3e-04 | -2.4 | -6.5 | 1.2e-10 | 0.01 | 0.03 | 0.37 | FALSE |
| 15 | GTEx | Breast Mammary Tissue | FKRP | 0.30 | 0.26 | lasso | 4 | 0.26 | 1.0e-13 | -5.1 | -5.3 | 1.3e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Cells EBV-transformed lymphocytes | PRKD2 | 0.25 | 0.08 | enet | 13 | 0.12 | 1.3e-04 | -8.1 | -7.6 | 2.2e-14 | -0.07 | 0.01 | 0.96 | FALSE |
| 17 | GTEx | Cells Transformed fibroblasts | PRKD2 | 0.29 | 0.19 | lasso | 5 | 0.20 | 3.6e-15 | -8.1 | -8.3 | 1.1e-16 | -0.04 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Cells Transformed fibroblasts | FKRP | 0.19 | 0.08 | lasso | 3 | 0.11 | 1.2e-08 | -5.4 | -7.4 | 1.2e-13 | -0.07 | 0.09 | 0.91 | FALSE |
| 19 | GTEx | Colon Sigmoid | FKRP | 0.54 | 0.34 | enet | 21 | 0.37 | 3.5e-14 | -5.1 | -6.8 | 1.5e-11 | -0.07 | 0.54 | 0.46 | FALSE |
| 20 | GTEx | Esophagus Gastroesophageal Junction | FKRP | 0.46 | 0.41 | enet | 18 | 0.42 | 2.5e-16 | -5.4 | -5.4 | 5.5e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Esophagus Muscularis | FKRP | 0.45 | 0.36 | lasso | 5 | 0.47 | 5.3e-32 | -6.0 | -7.3 | 2.0e-13 | -0.08 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Esophagus Muscularis | PPM1N | 0.11 | 0.16 | enet | 6 | 0.14 | 6.1e-09 | 4.8 | 5.5 | 2.9e-08 | -0.34 | 0.99 | 0.01 | FALSE |
| 23 | GTEx | Heart Atrial Appendage | FKRP | 0.24 | 0.20 | lasso | 4 | 0.22 | 4.7e-10 | -5.1 | -5.3 | 1.4e-07 | -0.08 | 0.97 | 0.02 | FALSE |
| 24 | GTEx | Heart Left Ventricle | FKRP | 0.23 | 0.18 | lasso | 4 | 0.22 | 4.5e-12 | -5.1 | -7.2 | 7.3e-13 | -0.07 | 0.10 | 0.90 | FALSE |
| 25 | GTEx | Lung | FKRP | 0.26 | 0.24 | lasso | 5 | 0.23 | 1.3e-17 | -5.1 | -5.1 | 3.0e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Lung | PPM1N | 0.18 | 0.14 | lasso | 4 | 0.13 | 4.5e-10 | 4.8 | 5.7 | 9.9e-09 | -0.32 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Muscle Skeletal | PRKD2 | 0.09 | 0.05 | lasso | 3 | 0.09 | 9.6e-09 | 2.3 | -6.5 | 9.3e-11 | -0.06 | 0.02 | 0.98 | FALSE |
| 28 | GTEx | Muscle Skeletal | FKRP | 0.23 | 0.18 | enet | 10 | 0.23 | 6.0e-22 | -6.0 | -7.2 | 7.5e-13 | -0.09 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Nerve Tibial | PRKD2 | 0.20 | 0.09 | enet | 12 | 0.16 | 2.1e-11 | -8.0 | -7.7 | 1.1e-14 | -0.07 | 0.00 | 1.00 | FALSE |
| 30 | GTEx | Nerve Tibial | FKRP | 0.41 | 0.43 | enet | 24 | 0.47 | 3.4e-37 | -5.4 | -6.8 | 1.2e-11 | -0.10 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Nerve Tibial | DMWD | 0.24 | 0.07 | lasso | 6 | 0.06 | 5.8e-05 | -4.2 | 5.2 | 2.4e-07 | -0.03 | 1.00 | 0.00 | TRUE |
| 32 | GTEx | Pancreas | FKRP | 0.16 | 0.08 | enet | 5 | 0.08 | 2.1e-04 | -5.6 | -5.7 | 1.3e-08 | -0.11 | 0.51 | 0.09 | FALSE |
| 33 | GTEx | Pituitary | FKRP | 0.38 | 0.21 | enet | 7 | 0.18 | 2.7e-05 | -6.0 | -5.4 | 8.2e-08 | -0.10 | 0.30 | 0.29 | FALSE |
| 34 | GTEx | Prostate | FKRP | 0.35 | 0.27 | lasso | 5 | 0.24 | 1.1e-06 | -5.1 | -5.2 | 2.0e-07 | -0.09 | 0.24 | 0.24 | FALSE |
| 35 | GTEx | Skin Not Sun Exposed Suprapubic | PRKD2 | 0.14 | 0.09 | lasso | 2 | 0.06 | 3.6e-04 | -6.0 | -6.0 | 2.7e-09 | -0.10 | 0.31 | 0.42 | FALSE |
| 36 | GTEx | Skin Not Sun Exposed Suprapubic | FKRP | 0.35 | 0.25 | enet | 18 | 0.30 | 7.9e-17 | -5.1 | -6.9 | 6.8e-12 | -0.07 | 0.41 | 0.59 | FALSE |
| 37 | GTEx | Skin Sun Exposed Lower leg | ERCC1 | 0.17 | 0.14 | lasso | 2 | 0.14 | 6.5e-12 | -5.9 | -5.8 | 5.0e-09 | 0.06 | 1.00 | 0.00 | TRUE |
| 38 | GTEx | Skin Sun Exposed Lower leg | RTN2 | 0.21 | 0.06 | lasso | 6 | 0.10 | 6.8e-09 | -8.3 | -5.7 | 1.6e-08 | 0.28 | 0.99 | 0.00 | TRUE |
| 39 | GTEx | Skin Sun Exposed Lower leg | FKRP | 0.29 | 0.26 | lasso | 5 | 0.27 | 3.5e-22 | -5.1 | -6.4 | 1.3e-10 | -0.08 | 1.00 | 0.00 | FALSE |
| 40 | GTEx | Stomach | FKRP | 0.29 | 0.18 | lasso | 6 | 0.18 | 9.1e-09 | -5.1 | -5.4 | 8.3e-08 | -0.10 | 0.94 | 0.05 | FALSE |
| 41 | GTEx | Thyroid | PRKD2 | 0.09 | 0.07 | lasso | 2 | 0.07 | 4.9e-06 | -8.4 | -8.4 | 4.8e-17 | -0.02 | 0.00 | 1.00 | FALSE |
| 42 | GTEx | Thyroid | FKRP | 0.50 | 0.36 | lasso | 10 | 0.40 | 2.2e-32 | -5.1 | -5.8 | 5.2e-09 | -0.08 | 1.00 | 0.00 | FALSE |
| 43 | METSIM | Adipose | FKRP | 0.28 | 0.25 | enet | 20 | 0.26 | 2.3e-39 | -5.1 | -6.4 | 1.7e-10 | -0.09 | 1.00 | 0.00 | FALSE |
| 44 | METSIM | Adipose | PRKD2 | 0.12 | 0.12 | enet | 14 | 0.13 | 3.2e-19 | -6.0 | -5.7 | 1.5e-08 | -0.09 | 1.00 | 0.00 | FALSE |
| 45 | NTR | Blood | SIX5 | 0.03 | 0.00 | blup | 381 | 0.00 | 2.6e-02 | 5.3 | 7.2 | 6.8e-13 | -0.28 | 0.04 | 0.05 | TRUE |
| 46 | YFS | Blood | FKRP | 0.24 | 0.16 | enet | 46 | 0.22 | 1.7e-68 | -5.1 | -6.9 | 6.1e-12 | -0.07 | 1.00 | 0.00 | FALSE |
| 47 | YFS | Blood | PRKD2 | 0.19 | 0.06 | lasso | 8 | 0.18 | 2.3e-55 | 3.5 | -6.0 | 2.7e-09 | -0.05 | 0.67 | 0.33 | FALSE |
| 48 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FKRP | 0.06 | 0.03 | blup | 40 | 0.07 | 3.9e-14 | -8.1 | -6.7 | 2.0e-11 | -0.07 | 0.00 | 1.00 | FALSE |
| 49 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PRKD2 | 0.04 | 0.02 | blup | 57 | 0.02 | 9.1e-06 | -7.8 | -7.1 | 9.1e-13 | -0.06 | 0.00 | 0.98 | FALSE |
| 50 | The Cancer Genome Atlas | Colon Adenocarcinoma | FKRP | 0.15 | 0.15 | lasso | 1 | 0.13 | 4.8e-08 | -8.0 | -8.0 | 9.6e-16 | -0.02 | 0.00 | 1.00 | FALSE |
| 51 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FKRP | 0.13 | 0.10 | lasso | 7 | 0.16 | 3.5e-18 | -6.0 | -8.0 | 1.2e-15 | -0.07 | 0.10 | 0.90 | FALSE |
| 52 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPM1N | 0.09 | 0.11 | lasso | 3 | 0.10 | 7.1e-12 | 5.6 | 5.9 | 4.5e-09 | -0.30 | 1.00 | 0.00 | FALSE |
| 53 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRKD2 | 0.08 | 0.07 | lasso | 2 | 0.07 | 7.6e-08 | -8.4 | -8.4 | 4.9e-17 | -0.02 | 0.00 | 1.00 | FALSE |
| 54 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ERCC2 | 0.17 | 0.03 | enet | 20 | 0.05 | 5.3e-04 | -3.8 | 5.8 | 5.1e-09 | -0.20 | 0.02 | 0.16 | TRUE |
| 55 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FKRP | 0.12 | 0.07 | enet | 9 | 0.11 | 1.1e-06 | -5.1 | -7.2 | 5.8e-13 | -0.08 | 0.18 | 0.80 | FALSE |
| 56 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPM1N | 0.08 | 0.10 | lasso | 3 | 0.10 | 3.4e-06 | 4.8 | 6.7 | 1.6e-11 | -0.39 | 0.34 | 0.20 | FALSE |
| 57 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRKD2 | 0.11 | 0.09 | blup | 57 | 0.08 | 1.6e-05 | -8.1 | -7.4 | 1.7e-13 | -0.03 | 0.00 | 1.00 | FALSE |
| 58 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC1A5 | 0.07 | 0.02 | blup | 29 | 0.03 | 5.2e-03 | -6.8 | 5.6 | 2.6e-08 | 0.05 | 0.01 | 0.10 | FALSE |
| 59 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | VASP | 0.07 | 0.03 | blup | 51 | 0.03 | 6.2e-03 | 3.4 | 6.4 | 1.4e-10 | -0.53 | 0.02 | 0.42 | TRUE |
| 60 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FKRP | 0.09 | 0.07 | enet | 5 | 0.07 | 8.8e-09 | -8.1 | -8.0 | 1.2e-15 | -0.07 | 0.00 | 1.00 | FALSE |
| 61 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPM1N | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.9e-09 | 5.6 | 5.6 | 2.6e-08 | -0.27 | 1.00 | 0.00 | FALSE |
| 62 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRKD2 | 0.24 | 0.14 | lasso | 7 | 0.25 | 4.7e-28 | -5.4 | -6.7 | 1.8e-11 | -0.08 | 0.95 | 0.05 | FALSE |
| 63 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FKRP | 0.09 | 0.06 | blup | 40 | 0.07 | 2.6e-04 | -7.8 | -8.6 | 6.3e-18 | -0.07 | 0.01 | 0.93 | FALSE |
| 64 | The Cancer Genome Atlas | Lung Adenocarcinoma | FKRP | 0.03 | 0.01 | enet | 9 | 0.02 | 4.9e-03 | -5.4 | -8.7 | 4.3e-18 | -0.07 | 0.01 | 0.86 | FALSE |
| 65 | The Cancer Genome Atlas | Lung Adenocarcinoma | PRKD2 | 0.05 | 0.01 | lasso | 4 | 0.00 | 3.3e-01 | -8.4 | -8.4 | 5.3e-17 | -0.04 | 0.00 | 0.98 | FALSE |
| 66 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FKRP | 0.05 | 0.04 | lasso | 3 | 0.05 | 7.6e-07 | -7.8 | -7.8 | 6.7e-15 | -0.05 | 0.00 | 0.99 | FALSE |
| 67 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FKRP | 0.05 | 0.06 | lasso | 3 | 0.05 | 3.8e-04 | -8.0 | -8.2 | 2.8e-16 | -0.02 | 0.00 | 0.98 | FALSE |
| 68 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FKRP | 0.23 | 0.00 | blup | 40 | 0.08 | 2.3e-04 | -3.0 | -6.6 | 4.6e-11 | -0.06 | 0.01 | 0.64 | FALSE |
| 69 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FKRP | 0.19 | 0.15 | enet | 12 | 0.23 | 3.7e-24 | -8.1 | -7.3 | 3.4e-13 | -0.06 | 0.00 | 1.00 | FALSE |
| 70 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPM1N | 0.06 | 0.05 | blup | 40 | 0.04 | 6.0e-05 | -8.3 | 7.1 | 1.1e-12 | -0.31 | 0.32 | 0.03 | FALSE |
| 71 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PRKD2 | 0.10 | 0.05 | lasso | 4 | 0.09 | 2.8e-09 | 2.3 | -6.2 | 4.5e-10 | -0.06 | 0.16 | 0.84 | FALSE |
| 72 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FKRP | 0.21 | 0.15 | lasso | 5 | 0.10 | 2.1e-03 | -8.4 | -8.4 | 6.1e-17 | -0.02 | 0.00 | 0.89 | FALSE |
| 73 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ERCC1 | 0.11 | 0.05 | lasso | 2 | 0.03 | 5.6e-03 | -5.9 | -5.5 | 5.1e-08 | 0.05 | 0.02 | 0.10 | FALSE |
| 74 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PPM1N | 0.10 | 0.07 | lasso | 3 | 0.06 | 2.4e-04 | 5.6 | 7.2 | 7.2e-13 | -0.43 | 0.08 | 0.12 | TRUE |
| 75 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PRKD2 | 0.13 | 0.12 | lasso | 3 | 0.09 | 6.7e-06 | -7.8 | -8.1 | 4.8e-16 | -0.03 | 0.09 | 0.90 | FALSE |
| 76 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PPM1N | 0.06 | 0.05 | lasso | 2 | 0.05 | 1.3e-04 | 5.6 | 6.1 | 1.2e-09 | -0.30 | 0.60 | 0.11 | FALSE |
| 77 | The Cancer Genome Atlas | Stomach Adenocarcinoma | VASP | 0.08 | 0.03 | enet | 14 | 0.04 | 1.2e-03 | -8.0 | 6.7 | 2.5e-11 | -0.44 | 0.18 | 0.07 | FALSE |
| 78 | The Cancer Genome Atlas | Thyroid Carcinoma | FKRP | 0.25 | 0.30 | enet | 14 | 0.37 | 2.1e-37 | -5.1 | -7.1 | 1.5e-12 | -0.08 | 1.00 | 0.00 | FALSE |
| 79 | The Cancer Genome Atlas | Thyroid Carcinoma | PPM1N | 0.04 | 0.03 | enet | 7 | 0.03 | 1.0e-03 | -8.0 | 6.2 | 5.0e-10 | -0.36 | 0.13 | 0.07 | FALSE |
| 80 | The Cancer Genome Atlas | Thyroid Carcinoma | PRKD2 | 0.11 | 0.09 | lasso | 3 | 0.07 | 2.5e-07 | -8.1 | -8.2 | 2.7e-16 | -0.02 | 0.00 | 1.00 | FALSE |