Best TWAS P=1.15e-37 · Best GWAS P=5.06e-23 conditioned to 2.14e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | AXL | 0.16 | 0.08 | lasso | 6 | 0.06 | 1.7e-05 | 4.44 | 5.4 | 7.8e-08 | 0.18 | 0.96 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TMEM91 | 0.08 | 0.00 | enet | 31 | 0.01 | 7.4e-02 | -2.21 | -8.2 | 1.5e-16 | -0.06 | 0.13 | 0.04 | TRUE |
| 3 | GTEx | Esophagus Muscularis | AXL | 0.12 | 0.00 | enet | 13 | 0.02 | 2.2e-02 | 4.64 | 6.2 | 4.1e-10 | -0.05 | 0.21 | 0.08 | FALSE |
| 4 | GTEx | Lung | AXL | 0.12 | 0.06 | lasso | 7 | 0.06 | 1.7e-05 | 7.00 | 6.2 | 6.2e-10 | 0.14 | 0.93 | 0.00 | FALSE |
| 5 | GTEx | Nerve Tibial | B9D2 | 0.13 | 0.08 | lasso | 4 | 0.06 | 2.9e-05 | -5.07 | -5.2 | 1.8e-07 | 0.12 | 0.46 | 0.02 | FALSE |
| 6 | YFS | Blood | TMEM91 | 0.50 | 0.05 | enet | 85 | 0.25 | 5.4e-82 | -1.04 | -6.7 | 2.0e-11 | -0.04 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | B9D2 | 0.08 | 0.05 | blup | 37 | 0.08 | 3.4e-05 | -5.27 | -9.0 | 2.0e-19 | 0.03 | 0.08 | 0.74 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | AXL | 0.19 | 0.00 | blup | 55 | 0.06 | 4.2e-03 | -9.88 | 12.8 | 1.1e-37 | -0.44 | 0.01 | 0.50 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BCKDHA | 0.10 | 0.00 | blup | 34 | 0.02 | 9.2e-04 | 0.82 | -5.4 | 8.0e-08 | -0.04 | 0.01 | 0.03 | TRUE |
| 10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ATP5SL | 0.23 | 0.05 | blup | 18 | 0.05 | 4.5e-03 | -4.19 | 5.8 | 6.2e-09 | 0.00 | 0.01 | 0.50 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | AXL | 0.05 | 0.02 | blup | 54 | 0.02 | 4.5e-03 | 6.65 | 6.2 | 5.3e-10 | -0.08 | 0.17 | 0.08 | FALSE |