[Hub]/) : Traits : Heel T-Score :

chr20:29,833,609-31,312,916

Best TWAS P=7.64e-13 · Best GWAS P=1.08e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous COX4I2 0.09 0.11 lasso 3 0.11 5.3e-09 6.5 7.2 7.6e-13 0.97 0.01 0.99 TRUE
2 GTEx Brain Caudate basal ganglia COX4I2 0.24 0.03 lasso 6 0.05 1.1e-02 6.2 5.4 7.9e-08 0.63 0.05 0.81 FALSE
3 GTEx Brain Nucleus accumbens basal ganglia COX4I2 0.13 0.14 lasso 5 0.05 2.2e-02 6.2 5.6 1.8e-08 0.83 0.06 0.57 FALSE
4 GTEx Cells Transformed fibroblasts HM13 0.07 0.05 lasso 4 0.06 3.9e-05 5.6 6.1 1.2e-09 0.81 0.04 0.95 FALSE
5 GTEx Cells Transformed fibroblasts HM13-AS1 0.04 0.01 lasso 3 0.01 1.0e-01 5.6 -5.8 6.6e-09 -0.85 0.07 0.69 FALSE
6 GTEx Esophagus Muscularis COX4I2 0.09 0.12 enet 10 0.09 4.1e-06 6.4 6.7 2.9e-11 0.99 0.02 0.98 FALSE
7 GTEx Lung COX4I2 0.05 0.01 enet 6 0.03 1.8e-03 6.5 7.0 2.4e-12 0.94 0.03 0.91 FALSE
8 GTEx Muscle Skeletal HM13 0.05 0.01 enet 15 0.05 2.1e-05 4.8 -6.2 4.2e-10 -0.70 0.04 0.91 FALSE
9 GTEx Muscle Skeletal COX4I2 0.10 0.08 lasso 4 0.09 3.5e-09 6.4 6.9 6.8e-12 0.93 0.02 0.98 FALSE
10 GTEx Nerve Tibial COX4I2 0.13 0.10 lasso 9 0.07 6.6e-06 6.4 6.2 4.1e-10 0.97 0.01 0.99 FALSE
11 GTEx Skin Not Sun Exposed Suprapubic COX4I2 0.08 0.05 lasso 4 0.05 1.5e-03 6.2 6.0 1.9e-09 0.89 0.03 0.96 FALSE
12 GTEx Skin Sun Exposed Lower leg COX4I2 0.03 0.04 enet 6 0.04 3.6e-04 6.5 6.1 9.9e-10 0.98 0.03 0.95 FALSE
13 GTEx Skin Sun Exposed Lower leg HM13-AS1 0.07 0.07 enet 11 0.05 5.3e-05 6.0 -6.9 6.1e-12 -0.78 0.05 0.95 FALSE
14 GTEx Thyroid COX4I2 0.04 0.05 lasso 2 0.03 1.8e-03 6.5 6.5 6.5e-11 1.00 0.02 0.96 FALSE
15 GTEx Vagina COX4I2 0.17 0.12 lasso 2 0.16 1.5e-04 6.4 6.3 3.7e-10 0.84 0.03 0.88 FALSE
16 NTR Blood C20orf160 0.01 0.00 bslmm 305 0.00 8.0e-03 6.5 -6.7 1.6e-11 -0.74 0.03 0.61 FALSE
17 NTR Blood HM13 0.03 0.05 lasso 6 0.05 2.2e-15 5.7 5.7 1.1e-08 0.82 0.22 0.78 FALSE
18 ROSMAP Brain Pre-frontal Cortex HM13 0.08 0.14 lasso 4 0.15 3.7e-19 5.6 -6.3 3.0e-10 -0.94 0.08 0.92 FALSE
19 YFS Blood HM13 0.08 0.10 lasso 6 0.10 3.6e-31 5.5 5.9 4.1e-09 0.85 0.15 0.85 FALSE
20 The Cancer Genome Atlas Glioblastoma Multiforme ID1 0.12 0.01 enet 4 0.05 1.3e-02 5.5 -6.4 1.6e-10 -0.73 0.01 0.35 FALSE
21 The Cancer Genome Atlas Glioblastoma Multiforme MYLK2 0.30 0.10 blup 43 0.16 1.3e-05 5.2 -6.2 7.3e-10 -0.63 0.01 0.84 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma COX4I2 0.06 0.03 lasso 3 0.03 1.5e-04 3.8 5.4 7.4e-08 0.95 0.01 0.97 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma MYLK2 0.06 0.02 blup 43 0.04 8.0e-06 5.9 -6.0 2.5e-09 -0.67 0.01 0.99 FALSE
24 The Cancer Genome Atlas Lung Adenocarcinoma COX4I2 0.04 0.06 enet 6 0.05 9.8e-07 6.2 6.3 2.2e-10 0.87 0.01 0.99 FALSE
25 The Cancer Genome Atlas Lung Squamous Cell Carcinoma COX4I2 0.04 0.03 blup 25 0.04 2.5e-05 3.7 5.4 8.1e-08 0.89 0.02 0.98 FALSE
26 The Cancer Genome Atlas Prostate Adenocarcinoma COX4I2 0.07 0.07 lasso 5 0.07 2.0e-07 6.5 6.2 7.3e-10 0.98 0.00 1.00 FALSE
27 The Cancer Genome Atlas Stomach Adenocarcinoma COX4I2 0.09 0.03 blup 25 0.03 3.8e-03 6.4 6.3 2.3e-10 0.83 0.01 0.71 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma COX4I2 0.02 0.03 lasso 2 0.03 1.0e-03 6.5 6.5 1.1e-10 1.00 0.00 0.89 FALSE