Hub : Genes

HM13

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0690	0.0320	3.7e-04	0.050	NA	0.055	NA	0.058	1.2e-04	NA	5.9e-05	NA	3.9e-05
2	GTEx	Esophagus Mucosa	0.0620	0.0350	9.5e-03	0.006	NA	-0.002	NA	0.001	1.1e-01	NA	4.5e-01	NA	2.7e-01
3	GTEx	Muscle Skeletal	0.0545	0.0265	3.6e-04	0.012	NA	0.047	NA	0.041	1.9e-02	NA	2.1e-05	NA	6.4e-05
4	GTEx	Whole Blood	0.0530	0.0240	1.9e-05	0.052	NA	0.033	NA	0.052	1.5e-05	NA	4.7e-04	NA	1.4e-05
5	NTR	Blood	0.0265	0.0091	1.8e-12	0.051	0.041	0.044	0.046	0.049	5.0e-16	3.8e-13	3.6e-14	9.1e-15	2.3e-15
6	ROSMAP	Brain Pre-frontal Cortex	0.0790	0.0230	1.7e-16	0.138	0.131	0.149	0.135	0.153	2.2e-17	1.9e-16	1.2e-18	6.3e-17	3.7e-19
7	YFS	Blood	0.0806	0.0238	0.0e+00	0.101	0.098	0.086	0.100	0.101	3.8e-31	3.1e-30	1.4e-26	6.4e-31	3.6e-31
8	TCGA	Bladder Urothelial Carcinoma	0.2230	0.0790	5.3e-08	0.009	0.066	0.082	NA	0.070	5.7e-02	2.9e-06	1.9e-07	NA	1.4e-06
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0570	0.0296	8.0e-08	0.035	0.069	0.056	NA	0.054	7.8e-05	3.0e-08	5.8e-07	NA	9.1e-07
10	TCGA	Brain Lower Grade Glioma	0.1553	0.0662	2.7e-06	0.052	0.053	0.044	NA	0.044	1.4e-06	1.1e-06	8.9e-06	NA	9.7e-06
11	TCGA	Lung Squamous Cell Carcinoma	0.0506	0.0331	1.0e-04	0.013	0.024	0.018	NA	0.013	1.2e-02	8.1e-04	3.3e-03	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.9	1.4	5.3	-0.3	-2.3	0.6	-1.1	-0.4	0.2	-0.1	-2.0	-1.1	-1.7	-0.4
Bipolar Disorder or Schizophrenia	0.8	1.9	5.8	-0.7	-2.4	0.5	-1.6	-1.2	1.2	-0.7	-0.9	-1.7	-1.7	-1.4
Depressed Affect (Nagel 2018)	1.9	4.1	7.1	2.3	1.9	-1.5	1.9	2.2	-2.3	2.0	1.8	2.3	0.6	2.7
Depression (Nagel 2018)	1.3	2.0	2.9	1.6	1.4	-0.9	1.2	1.7	-1.7	1.4	1.3	1.7	0.5	1.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	-1.1	-0.7	1.8	-1.1	-0.9	1.4	-0.9	-0.0	-0.6	1.1	-0.0
Neuroticism (Nagel 2018)	0.4	1.0	1.9	1.1	0.7	-0.3	1.0	1.3	-1.2	1.1	-0.3	1.3	0.3	1.4
Schizophrenia (2018)	0.5	1.1	2.2	-0.7	-1.2	0.2	-1.1	-1.2	1.4	-0.7	0.5	-1.3	-0.8	-1.5
Schizophrenia vs Biploar Disorder	0.2	0.2	1.1	0.2	1.0	0.4	0.3	0.3	-0.3	0.3	0.6	0.4	-0.4	-0.2
Worry (Nagel 2018)	0.4	0.9	4.4	-0.8	-1.0	1.2	-1.1	-0.4	0.6	-0.6	-2.1	-0.6	-0.3	-0.7
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	-1.2	-1.9	1.0	-1.5	-1.0	1.4	-1.3	-0.6	-0.8	1.0	-0.7
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-0.7	-1.1	0.6	-1.0	-0.7	0.4	-0.8	-1.5	-1.1	-1.2	-1.0
Alzheimer’s Disease (including proxy)	1.4	2.1	5.8	-1.5	-2.4	1.6	-1.5	-1.2	1.4	-1.8	-0.8	-1.0	0.7	-1.1
Crohns Disease (2017)	0.9	2.0	3.2	1.4	1.8	-1.1	1.7	1.3	-1.2	1.5	1.5	1.4	0.5	1.6
Irritable Bowel Disease (IBD)	0.3	0.7	3.6	0.6	1.2	-1.9	0.7	0.2	-0.4	0.7	0.8	-0.1	-0.7	0.6
Ulcerative Colitis (UC)	0.5	0.9	2.1	-0.9	0.0	-1.2	-0.9	-1.0	0.8	-0.6	-0.5	-1.5	-1.4	-0.9
Major Depression (MDD)	0.7	0.9	2.1	-1.2	-1.5	1.0	-0.7	-1.2	1.0	-0.8	-0.3	-0.8	-0.3	-0.8
Reaction Time	0.1	0.2	1.0	0.0	-0.3	-0.2	-0.6	-0.0	0.1	-0.0	-0.4	-0.4	-1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.3	0.2	0.6	0.6	0.3	0.9	-0.4	0.4	0.3	1.1	1.5	1.2
Breast Cancer	2.1	5.1	9.3	1.9	2.3	-1.6	2.2	2.0	-1.9	2.0	3.0	2.8	2.5	2.3
Ovarian Cancer	0.3	0.4	1.1	1.1	0.0	-0.7	0.2	0.5	-0.4	0.8	0.5	0.1	-1.0	0.5
Prostate Cancer	0.3	0.4	3.3	-0.1	-1.8	0.6	-0.4	0.1	-0.0	-0.1	-0.6	-0.1	-0.5	0.4
Age at First Birth	0.2	0.3	1.1	-0.1	-0.9	0.1	0.1	0.2	0.2	-0.1	1.1	0.5	1.0	0.2
Bipolar Disorder (2011)	1.6	1.5	3.2	1.5	0.4	-1.8	1.4	1.5	-1.5	1.4	0.1	1.0	-0.5	1.4
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	-0.8	-0.6	0.5	-0.9	-0.9	0.9	-0.9	0.3	-0.7	0.4	-1.0
Coronary Artery Disease (CAD)	0.5	0.5	3.1	-0.5	0.2	-0.5	-0.0	-0.2	0.9	-0.5	0.9	0.3	1.8	0.6
Crohns Disease (2012)	0.4	0.7	1.8	1.3	-0.0	-0.3	1.0	1.0	-0.9	0.8	0.2	0.8	-0.6	1.1
Mean Putamen Volume	6.1	7.0	22.8	-1.4	-4.8	2.5	-2.8	-2.2	2.7	-2.3	-2.1	-2.8	-2.3	-1.8
Fasting Glucose	0.3	0.3	1.4	-0.2	-0.0	0.8	0.4	0.4	0.3	-0.1	1.2	0.7	1.0	0.2
HbA1C	0.2	0.3	1.0	0.3	1.0	-0.7	0.4	0.4	-0.5	0.3	0.6	0.4	-0.3	0.3
HDL Cholesterol	2.8	4.7	7.1	2.3	1.9	-2.3	2.5	2.6	-2.6	2.7	0.3	2.5	0.3	2.2
LDL Cholesterol	0.3	0.4	1.6	0.8	0.3	-0.4	0.5	0.6	-1.0	0.8	-0.2	0.2	-1.3	-0.3
Lupus	0.4	0.6	3.1	-0.6	-0.6	0.9	-0.4	-0.1	-0.2	-0.2	-1.8	-0.5	-1.2	-0.5
Neuroticism (2016)	0.2	0.2	0.7	0.1	0.7	-0.5	0.1	0.2	-0.2	0.1	0.8	0.4	0.9	0.6
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.5	-0.5	-0.7	0.1	0.5	-0.5	0.4	-0.1	0.0	-0.7	0.5
Rheumatoid Arthritis	0.2	0.3	0.8	-0.3	0.7	0.5	0.7	0.2	-0.4	0.5	0.1	0.5	0.9	-0.1
Schizophrenia (2014)	0.3	0.6	1.6	-0.1	-0.8	0.3	-0.8	-0.7	0.7	-0.3	0.2	-1.0	-1.3	-1.0
Triglycerides	4.3	7.0	12.8	-2.6	-0.8	2.4	-3.1	-3.3	2.9	-3.6	-0.5	-3.3	-0.8	-3.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.1	-0.8	-0.9	1.8	-1.0	-0.8	1.1	-1.3	-0.9	-1.2	-1.2	-1.0
Ulcerative Colitis	0.9	1.3	7.1	0.9	0.9	-2.7	0.6	0.5	-0.6	0.7	-0.6	-0.2	-1.8	0.5
Blood Eosinophil Count	0.9	6.8	11.5	-2.6	-3.4	2.3	-2.7	-2.6	3.3	-3.3	-2.1	-2.6	0.1	-2.1
Blood Platelet Count	9.1	105.4	196.0	-9.0	-14.0	10.7	-10.5	-9.2	10.2	-9.3	-10.8	-10.1	-6.5	-11.1
Blood Red Count	6.2	59.8	80.8	-8.6	-7.3	8.4	-8.0	-8.8	9.0	-8.4	-4.4	-8.2	-1.8	-8.7
Blood White Count	0.3	2.1	4.1	1.7	-0.2	-0.8	1.9	2.0	-1.5	1.6	-0.3	2.0	0.5	1.7
Heel T-Score	3.1	24.5	39.7	6.1	3.6	-6.2	4.9	5.7	-6.3	5.9	0.9	4.3	-2.4	4.8
BMI	1.0	5.9	11.4	-3.1	-0.1	3.4	-2.3	-2.9	3.0	-2.8	1.0	-1.8	2.2	-2.2
Height	1.1	21.1	44.0	3.8	6.6	-4.6	4.5	4.3	-5.1	5.2	3.3	4.9	2.8	4.4
Waist Hip Ratio (WHR)	0.6	2.9	6.3	1.6	2.3	-1.2	1.1	1.4	-1.5	1.6	2.5	1.7	1.2	2.0
Systolic Blood Pressure	3.7	18.6	29.6	-4.7	-3.2	2.6	-5.4	-5.4	4.9	-5.0	-2.2	-5.2	-0.7	-4.9
Smoking Status	4.3	10.3	15.8	4.0	2.6	-3.5	3.4	3.6	-3.8	3.9	1.2	3.2	-0.2	3.4
Allergy or Eczema	0.1	0.3	2.3	-0.3	0.1	-0.7	-0.0	0.1	0.2	-0.2	0.5	0.5	1.5	0.3
Cardiovascular Disease	3.0	9.9	15.9	-3.1	-3.1	2.8	-3.5	-3.6	4.0	-3.7	-1.9	-3.7	-0.8	-3.1
Hypothyroidism (self reported)	0.1	0.2	1.1	0.0	0.6	-0.4	0.0	-0.4	0.4	-0.6	1.0	-0.2	0.3	-0.4
Respiratory disease	3.0	6.6	10.9	2.5	2.6	-1.5	3.3	2.9	-3.1	2.7	1.3	3.0	1.4	3.0
Type 2 Diabetes (T2D) (2018)	1.3	2.4	4.6	-1.5	-0.7	1.3	-1.6	-2.0	1.8	-2.2	-1.1	-2.0	-0.3	-1.5
Lung FEV1/FVC ratio	0.5	2.3	4.9	-1.3	1.0	1.0	-2.0	-2.0	1.0	-1.7	0.1	-1.8	-1.3	-2.2
Lung FVC	4.6	23.6	56.9	-3.6	-7.5	4.8	-5.0	-3.9	4.9	-4.0	-5.1	-5.0	-3.9	-4.4
Neuroticism	0.3	0.7	1.5	0.9	0.4	-0.1	0.7	1.1	-1.2	1.2	-0.7	0.9	-0.2	1.0
Chronotype (morning person)	0.4	1.0	3.6	-0.8	-0.7	1.9	-1.3	-0.5	0.3	-0.7	-1.7	-0.8	-0.6	-0.7
Hair Pigment	0.7	20.7	28.0	-4.2	-5.2	5.3	-5.1	-4.1	4.4	-4.2	-4.0	-4.5	-3.5	-5.0
Tanning	0.2	2.8	7.2	1.2	2.5	-2.7	2.2	1.4	-1.4	1.0	0.7	1.4	1.2	1.8
Hand grip strength (left)	0.1	0.3	1.0	-0.3	0.1	0.5	-1.0	-0.6	0.6	-0.1	0.4	-0.5	-0.3	-0.5
Number of treatments/medications taken	1.3	2.3	4.8	-1.1	-0.9	1.1	-1.8	-2.0	1.4	-1.8	-0.7	-2.2	-1.3	-1.6
Average weekly spirits intake	1.6	2.0	3.5	-1.3	-1.9	0.5	-1.4	-1.6	1.6	-1.5	-1.1	-1.8	-1.0	-1.4
Sensitivity / hurt feelings	1.7	2.8	4.5	2.1	1.3	-1.6	2.0	2.1	-2.0	1.9	0.6	1.9	-0.1	1.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.0	0.7	1.0	-0.6	0.3	0.5	-0.7	0.4	0.1	0.2	-0.6	0.2
Hearing difficulty/problems: Yes	5.1	7.7	10.9	2.9	2.2	-3.2	2.6	3.0	-3.3	3.1	1.7	3.1	1.1	3.3
Relative age of first facial hair	0.7	1.5	3.2	1.5	0.8	-0.7	0.7	1.4	-1.5	1.8	-0.7	0.8	-1.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.2	-0.3	-0.2	-0.9	-0.6	0.8	-0.7	0.4	-0.6	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	3.1	3.9	7.9	1.3	2.8	-0.4	2.3	1.5	-1.8	2.2	2.2	2.3	2.0	1.9
Ever had hysterectomy (womb removed)	1.7	2.0	3.4	-1.6	0.0	1.2	-1.3	-1.8	1.3	-1.5	-1.2	-1.8	-0.9	-1.8
Systolic blood pressure, automated reading	3.4	9.8	17.5	-4.0	-1.4	1.7	-3.8	-4.2	3.6	-3.5	-1.5	-3.8	0.3	-3.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.1	-0.4	1.5	0.4	-0.0	-0.5	-0.2	-0.6	0.3	-0.1	0.6	-0.6
Angina	0.7	1.0	1.9	-1.0	0.2	1.1	-0.8	-1.3	1.4	-1.3	0.3	-1.1	0.2	-1.0
Medication for hormone replacement therapy	0.8	0.9	2.0	1.4	0.9	-0.4	0.9	0.8	-1.0	1.0	1.4	0.6	-0.8	0.9
Vitamin and mineral supplements	1.2	1.7	3.6	0.5	1.4	0.0	1.7	1.1	-0.7	0.9	1.6	1.6	1.9	1.4
Supplements: Zinc	1.4	1.6	2.6	-0.8	-1.6	0.5	-1.2	-1.4	1.5	-1.3	-0.6	-1.6	-1.2	-1.4
Medication: Co-codamol	0.5	0.6	1.3	0.6	0.6	-0.5	1.1	0.9	-1.1	1.1	0.1	0.9	-0.2	0.4
Medication: Metformin	2.3	3.2	6.4	-1.4	-1.0	0.9	-2.0	-2.1	1.9	-2.2	-0.8	-2.5	-1.7	-2.0
Diabetes (father)	0.5	0.7	1.8	-0.7	-0.8	0.7	-1.3	-1.0	0.6	-0.9	-0.4	-0.9	-0.3	-0.8
Diabetes (mother)	0.6	0.8	1.5	-1.1	0.9	-1.2	-0.5	-1.1	0.7	-1.2	-0.1	-0.8	0.8	-0.6
Severe depression (siblings)	0.4	0.5	2.4	-0.5	1.0	-0.2	0.1	-0.7	0.4	-0.7	0.3	-0.1	1.6	-0.1
Pack years adult smoking proportion	0.9	1.3	2.9	1.4	0.9	0.2	1.7	1.1	-1.1	1.1	1.6	1.3	0.1	1.1
Impedance of leg (right)	0.6	2.8	6.0	2.1	1.4	-2.4	1.9	1.6	-2.1	1.8	-0.1	0.9	-1.3	1.6
Leg fat-free mass (left)	0.3	1.7	6.9	-0.5	2.3	-0.0	0.2	0.2	-0.2	0.5	2.0	1.2	2.6	0.3
Trunk fat percentage	0.3	1.4	4.9	-1.5	1.7	-0.4	-0.3	-1.2	0.7	-1.0	1.4	-0.3	2.2	-0.4
Hand grip strength (right)	0.1	0.4	1.8	0.2	0.8	-0.5	-0.1	0.2	-0.1	0.5	1.3	0.5	0.7	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.1	-0.3	0.6	0.1	-0.2	0.5	0.1	0.4	-0.2	-0.2	0.1
Current tobacco smoking	1.1	1.8	3.8	1.9	1.4	-1.8	1.2	1.3	-1.4	1.3	0.9	0.9	-0.9	1.4
Average weekly fortified wine intake	0.9	1.1	2.9	1.3	0.2	-0.7	1.1	1.2	-1.4	1.7	-0.6	0.8	-0.7	1.0
Maternal smoking around birth	5.5	8.0	14.5	-3.8	-1.3	2.7	-3.4	-3.5	3.0	-3.2	-2.0	-3.0	0.5	-2.9
Fed-up feelings	2.3	4.2	8.1	2.5	1.1	-2.8	2.0	2.1	-2.1	1.8	1.7	2.1	0.7	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.2	6.1	2.0	1.9	-1.7	1.9	2.1	-2.1	1.8	2.4	2.4	1.7	2.5
Relative age voice broke	1.1	1.7	8.2	-0.3	-0.7	0.7	-0.8	-0.3	0.2	0.1	-2.4	-1.1	-2.9	-1.3
Taking other prescription medications	0.1	0.1	0.5	0.3	-0.2	0.1	-0.1	-0.5	0.2	-0.2	0.7	-0.4	-0.4	-0.2
Age when periods started (menarche)	0.6	1.5	4.5	-1.1	-0.8	2.1	-1.5	-1.2	1.0	-1.2	-0.5	-1.3	-0.7	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.6	-0.2	0.2	0.9	0.3	-0.1	-0.1	-0.5	0.3	0.3	1.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	11.0	2.6	1.9	-3.3	1.9	2.1	-2.5	2.5	0.1	1.1	-2.2	1.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.9	-0.2	0.9	0.0	0.1	0.0	-0.1	0.1	1.6	0.7	1.7	0.4
Qualifications: CSEs or equivalent	0.3	0.5	1.7	-0.0	-1.0	1.3	-0.3	0.1	-0.1	-0.1	-1.3	-0.2	-0.7	-0.2
Serious illness, injury or assault to yourself	1.9	2.3	3.7	-1.2	-1.5	1.5	-1.6	-1.5	1.8	-1.9	-1.3	-1.7	-0.9	-1.5
High blood pressure	3.6	10.0	16.6	-3.7	-2.9	3.2	-3.2	-3.8	4.1	-3.9	-1.1	-3.2	0.8	-3.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.6	-0.4	0.5	-0.4	-0.3	0.0	0.2	-0.3	0.7	0.4	1.6	0.0
Multivitamins +/- minerals	0.5	0.6	2.0	0.2	-0.7	-1.2	-0.8	-0.5	0.2	-0.2	-0.6	-0.9	-1.4	-0.7
Stomach or abdominal pain in last month	0.7	0.9	1.9	-0.2	-1.0	1.4	-1.1	-0.9	0.9	-0.8	0.4	-1.0	-1.2	-0.8
Supplements: Glucosamine	0.2	0.2	0.7	-0.2	0.2	-0.1	-0.7	-0.5	0.3	-0.5	-0.5	-0.8	-0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	-0.3	0.1	-0.1	0.3	-0.1	0.1	-0.2	-0.1	0.2	0.7	-0.2
Medication: Atenolol	2.1	2.6	5.3	-1.7	-0.8	1.7	-1.4	-1.9	1.8	-2.0	-0.6	-1.8	-0.7	-2.3
Medication: Levothyroxine sodium	0.3	0.5	1.6	-0.2	-0.4	0.3	-0.8	-0.5	0.4	-0.6	-0.6	-0.9	-1.3	-0.9
Sitting height	7.4	52.6	79.0	7.0	8.9	-6.6	7.7	7.7	-8.2	8.0	5.0	8.2	3.3	7.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.9	-0.4	1.2	-0.3	-0.6	1.0	-0.8	0.3	-0.1	1.2	-0.5
High blood pressure (mother)	0.2	0.3	1.4	-0.2	0.7	-0.5	0.1	-0.3	0.3	-0.5	1.2	0.0	0.9	-0.2
Body mass index (BMI)	0.8	3.2	6.2	-2.5	-0.4	1.8	-2.0	-2.3	2.2	-2.1	0.5	-1.5	1.3	-1.8
Impedance of leg (left)	0.4	2.2	5.3	1.8	1.0	-2.3	1.9	1.4	-1.7	1.4	-0.3	0.7	-1.2	1.3
Leg predicted mass (left)	0.3	1.6	6.6	-0.5	2.2	-0.0	0.2	0.1	-0.1	0.5	2.0	1.1	2.6	0.3
Trunk fat mass	0.4	1.7	7.0	-1.2	2.3	-0.5	-0.1	-0.8	0.4	-0.6	1.9	0.2	2.6	-0.2
Waist circumference	0.4	1.6	5.4	-1.8	0.9	0.5	-1.1	-1.4	1.3	-1.1	1.4	-0.4	2.3	-0.7
Number of incorrect matches in round	1.0	1.6	8.3	0.1	-1.4	0.0	-0.7	-0.5	0.5	-0.6	-1.9	-1.5	-2.9	-0.9
Past tobacco smoking	1.4	2.5	4.5	-2.0	-0.7	1.5	-1.7	-1.9	1.7	-2.1	-0.5	-1.8	0.1	-1.9
Alcohol usually taken with meals	0.3	0.5	2.4	-0.9	1.3	-0.5	0.4	0.1	0.1	0.1	0.0	0.5	1.6	-0.1
Nervous feelings	0.2	0.3	1.5	-0.4	-0.6	0.7	-0.6	-0.1	0.2	-0.4	-1.2	-0.1	0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.7	1.3	0.6	-1.1	0.9	1.2	-1.0	1.0	0.7	0.9	-0.6	1.2
Hearing difficulty/problems with background noise	3.3	5.3	8.0	2.6	1.7	-1.9	2.6	2.7	-2.8	2.8	0.8	2.5	0.2	2.7
Hair/balding pattern: Pattern 2	0.4	0.5	3.1	0.6	-0.4	0.4	0.1	0.5	-0.5	0.2	-1.1	-0.0	-1.8	-0.1
Had menopause	2.3	2.8	7.2	-2.7	-0.1	0.2	-1.9	-2.3	1.9	-1.7	-0.9	-1.8	0.9	-1.9
Had other major operations	1.3	1.6	2.5	-1.2	-1.6	1.5	-1.0	-1.2	1.5	-1.4	-0.8	-1.2	-0.6	-1.5
Forced vital capacity (FVC)	0.5	1.9	6.8	-0.5	-2.6	1.3	-1.3	-0.6	0.9	-0.4	-1.8	-1.1	-1.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	10.8	2.0	2.0	-3.3	1.2	1.5	-2.2	2.1	-0.4	0.4	-2.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.2	0.8	0.1	-1.3	0.4	0.7	-0.5	0.9	1.8	1.0	1.2	1.2
Qualifications: None of the above	0.1	0.2	1.3	0.1	0.6	-1.1	0.1	-0.1	-0.4	-0.0	0.2	-0.1	-0.2	0.0
Financial difficulties in last 2 years	0.3	0.5	2.3	0.9	0.5	0.1	0.8	0.4	-0.3	0.2	1.5	0.6	0.1	0.6
Mouth/teeth dental problems	1.1	1.7	4.7	-0.8	-2.2	1.7	-1.5	-1.0	1.0	-1.0	-0.7	-1.2	-1.2	-1.3
Heart attack	0.5	0.6	1.0	-0.2	-0.1	0.8	-0.8	-1.0	0.9	-0.7	1.0	-1.0	-0.8	-0.5
Allergy	1.3	3.0	5.9	-1.2	-2.4	1.7	-1.4	-1.4	1.4	-1.3	-2.0	-1.8	-2.0	-1.9
Pain all over the body in last month	2.3	2.4	3.6	-1.4	-1.4	1.5	-1.3	-1.6	1.6	-1.7	-1.9	-1.9	-1.1	-1.5
Diabetes (self-reported)	0.8	1.2	2.4	-0.8	-0.9	1.2	-1.1	-1.4	1.3	-1.6	-0.4	-1.4	-0.5	-1.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.1	-0.3	-0.3	-0.5	-0.2	0.4	-0.3	0.6	-0.4	-0.3	-0.2
Medication: Ramipril	0.4	0.5	1.4	-0.4	0.3	0.7	-0.4	-0.9	0.9	-0.8	1.2	-0.3	0.9	-0.3
Medication: Simvastatin	2.4	3.6	5.6	-2.1	-1.5	1.8	-2.0	-2.2	2.2	-2.4	-1.2	-2.2	-0.2	-1.9
Fluid intelligence score	0.2	0.5	2.4	-0.3	-0.6	1.1	-0.2	0.3	0.4	0.1	0.4	0.7	1.6	0.5
Illnesses of siblings	1.3	1.9	3.5	1.4	1.0	0.3	1.6	1.9	-1.4	1.4	1.0	1.8	0.6	1.6
Neuroticism score	1.3	2.6	4.8	2.0	0.5	-1.4	1.6	2.0	-1.7	1.8	1.2	1.9	0.4	2.2
Weight	0.3	1.4	6.7	-1.1	2.0	0.1	-0.2	-0.5	0.2	-0.2	1.7	0.6	2.6	-0.2
Impedance of arm (right)	0.0	0.2	1.0	-0.3	0.6	-1.0	0.3	-0.3	0.1	-0.3	0.3	-0.1	0.7	0.3
Arm fat percentage (right)	1.1	4.2	8.7	-2.9	0.2	1.3	-2.0	-2.7	2.5	-2.6	1.0	-1.7	2.0	-1.9
Trunk fat-free mass	0.3	1.8	6.8	0.2	2.6	-0.2	0.7	0.9	-0.9	1.2	1.6	1.6	2.0	0.6
Hip circumference	0.3	1.3	6.2	-1.5	1.3	0.4	-0.6	-0.9	0.8	-0.9	1.1	-0.0	2.5	-0.5
Time employed in main current job	0.1	0.1	0.8	-0.0	0.9	-0.0	0.3	0.1	-0.4	0.2	-0.2	0.1	-0.4	-0.4
Alcohol intake versus 10 years previously	3.6	5.5	8.2	-2.7	-1.2	1.8	-2.7	-2.7	2.5	-2.6	-2.0	-2.9	-0.9	-2.8
Father’s age at death	0.2	0.3	1.8	-0.1	0.4	0.4	0.1	0.1	-0.5	0.1	-1.3	-0.2	-0.8	-0.6
Worrier / anxious feelings	0.7	1.3	5.1	-0.6	-1.5	0.3	-1.1	-0.6	0.5	-0.8	-2.3	-1.0	-1.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	5.7	1.5	0.6	-0.9	0.6	0.7	-0.6	0.7	2.4	0.5	-0.4	1.2
Falls in the last year	2.2	3.0	5.9	-1.6	-2.1	1.3	-2.4	-1.7	2.2	-2.1	0.7	-1.7	-0.4	-1.3
Hair/balding pattern: Pattern 3	0.8	1.1	2.0	1.2	0.7	-0.5	1.1	1.3	-1.4	1.3	0.7	1.3	0.2	1.3
Number of live births	0.9	1.2	2.4	0.9	1.1	-0.6	1.4	1.4	-1.4	1.0	0.8	1.5	0.6	1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	7.2	-0.9	-2.7	1.9	-1.9	-1.2	1.5	-0.8	-1.8	-1.7	-2.1	-1.7
Pulse rate	0.1	0.2	0.8	-0.6	-0.4	0.9	-0.4	-0.4	0.6	-0.5	-0.2	-0.2	0.1	-0.4
Happiness	0.2	0.3	0.9	0.2	0.6	-0.4	0.3	0.2	-0.2	0.2	0.7	0.6	1.0	0.7
Noisy workplace	0.5	0.6	2.7	0.8	1.0	-0.7	0.4	0.5	-0.9	0.7	-0.3	-0.1	-1.6	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	0.3	1.0	-0.9	0.8	0.9	-0.4	0.4	1.4	1.3	1.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.3	-0.9	-0.8	0.2	-1.1	-0.7	0.7	-0.5	-1.3	-1.2	-1.5	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.8	7.8	-0.0	2.8	-1.1	1.0	0.4	-0.9	0.4	0.9	1.1	2.4	1.0
Asthma	2.8	5.5	8.4	2.2	2.9	-1.7	2.9	2.5	-2.7	2.5	1.3	2.6	1.3	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.7	-0.3	-1.6	0.5	-1.2	-0.5	0.5	-0.6	-0.2	-0.7	-0.9	-0.6
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.9	-0.1	0.4	-1.0	-1.2	1.2	-1.2	0.6	-1.1	0.2	-0.6
Depression (self-reported)	0.1	0.1	0.2	-0.1	-0.1	0.3	-0.1	-0.4	0.1	-0.2	-0.5	-0.4	-0.0	-0.3
Medication: Lansoprazole	0.7	0.8	1.6	0.6	1.0	-0.5	1.3	1.0	-0.8	0.8	0.2	1.1	0.7	1.1
Prospective memory result	0.2	0.3	1.4	-0.3	1.2	0.1	-0.1	-0.4	-0.1	-0.2	1.1	-0.2	0.1	-0.4
Lung cancer (father)	0.1	0.1	0.3	-0.2	0.6	0.1	-0.3	-0.5	0.3	-0.3	0.2	-0.4	0.1	-0.3
Illnesses of mother	2.0	2.4	3.9	2.0	0.7	-1.5	1.3	1.9	-1.8	2.0	1.2	1.6	-0.3	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	6.0	-1.1	-2.4	2.4	-1.8	-1.2	1.5	-1.0	-2.4	-1.8	-2.4	-1.8
Pulse wave Arterial Stiffness index	0.9	1.0	1.7	0.9	0.7	-1.1	0.7	1.2	-1.2	0.9	0.6	1.2	0.9	1.3
Impedance of arm (left)	0.1	0.4	2.1	0.2	0.5	-1.4	0.8	0.2	-0.5	0.2	-0.1	0.2	0.4	0.7
Arm fat mass (right)	0.6	2.4	5.2	-2.3	1.0	0.8	-1.4	-1.9	1.6	-1.7	1.1	-0.9	2.1	-1.4
Trunk predicted mass	0.3	1.8	6.7	0.2	2.6	-0.2	0.7	0.8	-0.9	1.2	1.6	1.6	2.0	0.6
Standing height	1.3	13.3	28.7	2.7	5.4	-3.4	3.6	3.6	-4.0	3.9	2.3	4.3	2.7	3.2
Length of working week for main job	2.1	2.3	5.1	-1.7	-1.0	1.0	-1.8	-2.0	2.3	-1.8	0.3	-1.6	0.5	-1.2
Exposure to tobacco smoke at home	2.1	2.4	4.7	-1.6	-1.1	2.2	-1.6	-1.7	1.9	-1.2	-1.5	-1.6	-0.4	-1.7
Breastfed as a baby	0.7	0.9	4.8	-0.4	-2.2	-0.1	-1.0	-0.5	0.8	-0.3	-0.4	-0.7	-1.1	-0.8
Tense / ‘highly strung’	0.3	0.4	0.8	0.3	-0.7	0.4	0.6	0.8	-0.6	0.8	-0.5	0.9	0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.4	0.2	-0.9	0.7	-0.3	-0.3	0.8	-0.3	1.5	-0.1	-0.2	-0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.1	-0.0	0.3	0.1	-0.3	0.4	-0.2	-0.0	-0.4	-0.2	-0.1
Birth weight of first child	1.6	2.9	6.0	-2.5	-1.4	1.9	-1.5	-1.9	2.0	-2.2	-0.2	-1.1	1.3	-1.6
Peak expiratory flow (PEF)	0.4	0.9	2.5	-0.8	-0.3	1.4	-1.0	-1.1	1.1	-0.7	-0.2	-1.0	-0.5	-1.6
Pulse wave reflection index	0.1	0.2	0.6	-0.4	-0.8	-0.2	-0.5	-0.0	-0.1	-0.4	-0.6	-0.1	0.1	-0.4
Ever highly irritable/argumentative for 2 days	3.1	3.8	5.5	1.8	2.3	-1.4	2.2	1.7	-1.9	1.6	2.2	2.1	1.6	2.2
Loud music exposure frequency	0.9	0.9	3.3	-0.8	-0.4	1.8	-0.9	-1.2	1.1	-1.0	-0.2	-0.8	0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.1	-1.3	-1.6	1.4	-1.2	-0.8	1.1	-0.9	-1.8	-1.1	-0.9	-1.1
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.8	0.2	1.4	-1.1	0.9	0.2	-0.3	0.3	1.6	0.7	1.7	0.6
Blood clot in the leg (DVT)	0.6	0.7	2.8	1.2	0.2	-1.0	0.1	0.7	-0.5	0.8	1.7	0.8	0.0	1.0
Medication: Paracetamol	5.6	9.2	12.6	-3.1	-2.5	3.4	-3.6	-3.4	3.0	-3.2	-2.5	-3.5	-1.4	-3.2
Headache pain in last month	0.4	0.6	1.2	-0.5	-1.0	0.2	-1.1	-0.8	0.9	-0.6	-0.5	-1.0	-1.0	-0.6
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	7.0	1.9	1.5	-1.1	2.2	2.5	-2.6	2.5	0.0	2.4	0.1	1.5
Glaucoma (self-reported)	0.3	0.3	1.7	0.4	-1.3	0.9	-0.4	0.2	0.2	-0.1	-0.2	-0.1	-0.5	0.4
Gout (self-reported)	6.1	8.3	13.1	-3.0	-3.1	3.6	-3.2	-2.8	3.4	-2.9	-2.3	-2.8	-0.5	-3.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.4	0.9	0.9	-1.1	0.6	0.5	-0.4	0.3	1.2	0.5	0.1	0.6
Medication: Amlodipine	0.1	0.2	0.6	0.4	0.1	-0.1	0.6	0.6	0.0	-0.1	0.4	0.6	0.5	0.8
Medication: Ventolin 100micrograms inhaler	3.7	4.8	9.6	2.3	3.1	-0.7	2.7	2.6	-3.0	2.3	-0.1	2.1	-0.3	2.0
Birth weight	0.2	0.4	1.9	-0.1	-0.7	0.5	-1.4	-0.4	0.3	-0.3	-0.2	-0.7	-1.1	-0.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.2	-1.5	-0.6	2.1	-1.5	-1.5	1.5	-1.1	-0.4	-1.4	-0.0	-1.0
High blood pressure (siblings)	0.6	0.9	2.0	-1.2	-0.2	-0.8	-1.1	-1.4	0.8	-0.8	-0.3	-1.2	0.1	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.5	5.2	-0.7	-2.3	2.0	-1.3	-0.7	1.1	-0.6	-2.2	-1.4	-2.2	-1.3
Body fat percentage	0.4	1.4	4.4	-1.6	1.4	-0.2	-0.5	-1.3	0.9	-1.1	1.4	-0.5	2.1	-0.6
Leg fat percentage (right)	0.3	0.9	1.7	-1.1	1.3	-0.1	-0.5	-1.2	0.8	-0.8	1.3	-0.7	1.3	-0.5
Arm fat-free mass (right)	0.3	1.3	5.2	0.1	2.3	-0.4	0.5	0.6	-0.7	1.0	1.4	1.3	1.7	0.4
Exposure to tobacco smoke outside home	2.5	3.3	7.1	-1.8	-2.3	2.7	-1.9	-1.5	2.0	-2.1	-1.5	-1.4	0.1	-1.7
Comparative body size at age 10	1.0	2.8	8.3	-2.5	-0.5	1.7	-1.7	-1.6	1.7	-1.8	0.5	-0.5	2.9	-0.9
Number of full brothers	2.4	3.0	5.5	2.3	0.2	-1.3	2.1	2.1	-1.5	2.1	1.2	2.1	0.3	2.1
Worry too long after embarrassment	0.7	1.1	2.2	1.0	1.5	-1.2	1.3	1.1	-1.1	0.9	0.7	1.2	0.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	5.8	-2.0	-2.3	1.6	-2.0	-2.1	2.4	-2.2	-0.7	-2.0	-0.0	-1.9
Wheeze or whistling in the chest in last year	2.4	4.3	12.2	1.2	3.5	-1.5	2.1	1.6	-1.7	1.8	2.4	2.1	2.1	2.0
Number of children fathered	0.2	0.3	1.3	-0.6	1.1	-0.5	0.4	-0.3	0.1	-0.2	-0.3	-0.1	0.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	-1.4	-1.2	1.6	-1.4	-1.2	1.7	-1.5	-0.1	-1.1	0.2	-1.3
Age at first live birth	0.2	0.4	1.4	0.4	-0.2	-0.3	0.5	0.6	-0.4	0.5	0.6	0.8	1.2	0.7
Pulse wave peak to peak time	0.3	0.4	0.7	-0.5	-0.3	0.8	-0.3	-0.8	0.8	-0.5	-0.3	-0.7	-0.6	-0.9
Health satisfaction	1.2	1.5	4.3	1.0	2.1	-1.1	1.2	0.9	-1.0	1.0	1.5	1.2	0.8	1.3
Shortness of breath walking on level ground	0.3	0.3	1.2	0.5	0.7	0.8	0.6	0.2	-0.1	0.3	1.1	0.4	-0.0	0.5
Qualifications: College or University degree	0.1	0.3	0.8	0.7	-0.9	0.1	0.3	0.6	-0.0	0.4	0.3	0.6	-0.1	0.8
Eye problems/disorders: None of the above	0.8	0.9	3.0	-0.9	-1.7	1.0	-0.8	-0.9	1.1	-0.4	-1.0	-0.8	-0.3	-0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.9	0.9	2.2	-1.8	1.0	0.7	-1.3	0.8	0.5	0.6	0.1	0.9
Emphysema/chronic bronchitis	0.8	0.9	1.8	1.0	0.5	-0.7	1.0	1.1	-1.3	1.0	-0.5	0.7	-0.4	1.3
Medication for pain relief, constipation, heartburn	4.6	7.9	11.2	2.9	2.7	-2.7	3.3	3.3	-3.0	3.0	2.1	3.3	0.9	2.8
Neck or shoulder pain in last month	0.4	0.5	1.3	-0.5	-0.5	0.4	-0.9	-0.7	0.5	-0.7	-0.7	-0.8	-1.1	-0.7
Medication: Blood pressure	3.0	5.3	10.3	-2.4	-2.0	2.3	-2.4	-2.9	3.2	-3.0	-0.1	-2.5	0.7	-1.8
Angina (self-reported)	0.4	0.5	1.0	-0.7	0.5	0.8	-0.5	-0.9	1.0	-0.9	0.3	-0.7	0.2	-0.8
Migraine (self-reported)	1.3	1.6	3.4	1.0	1.2	-1.1	1.3	1.1	-1.0	1.1	1.4	1.5	1.3	1.8
Medication: Ibuprofen	0.7	0.8	2.0	-0.5	-1.4	0.5	-1.1	-0.5	0.4	-0.6	-1.1	-0.8	-1.4	-0.9
Medication: Allopurinol	3.8	5.1	6.9	-2.5	-2.2	2.6	-2.6	-2.2	2.6	-1.9	-2.0	-2.2	-0.6	-2.5
Medication: Omeprazole	0.8	0.9	1.8	-0.6	-0.7	0.4	-1.2	-0.9	0.4	-0.8	-1.3	-1.2	-1.3	-0.9
Medication: Seretide 50 evohaler	1.1	1.3	5.3	-1.4	0.0	2.3	-0.6	-1.0	1.0	-1.0	0.5	-0.4	1.8	-0.5
Mean time to correctly identify matches	0.1	0.2	0.5	0.2	0.1	-0.6	-0.0	0.5	-0.2	0.3	0.6	0.3	0.2	0.7
Heart disease (mother)	0.1	0.1	0.7	-0.1	0.3	-0.2	0.3	-0.1	-0.2	-0.2	-0.8	-0.1	-0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.1	-0.4	0.9	0.0	0.5	0.3	-0.1	0.5	0.4	0.7	1.4	0.2
Whole body fat mass	0.4	1.5	6.3	-1.3	1.9	-0.3	-0.3	-0.9	0.6	-0.6	1.7	0.0	2.5	-0.3
Leg fat mass (right)	0.3	1.2	4.3	-1.0	1.9	-0.3	-0.3	-0.8	0.5	-0.6	1.8	-0.1	2.1	-0.2
Arm predicted mass (right)	0.4	1.9	6.2	0.4	2.5	-0.7	0.9	1.0	-1.1	1.3	1.6	1.7	1.8	0.8
Pulse rate, automated reading	0.4	1.5	3.2	-1.1	-1.6	1.8	-0.6	-1.1	1.7	-1.1	-0.4	-1.0	-0.7	-1.2
Alcohol intake frequency.	1.0	2.2	5.1	-1.7	-0.6	2.3	-1.5	-1.6	1.5	-2.1	-0.2	-1.4	0.1	-1.6
Comparative height size at age 10	0.2	0.9	3.9	-0.2	2.0	-0.8	0.5	0.4	-1.0	0.9	0.0	0.9	1.6	0.2
Number of full sisters	0.3	0.4	1.8	0.3	0.3	-0.0	0.7	0.7	-0.7	0.4	-1.4	0.3	-0.6	-0.0
Suffer from ‘nerves’	0.1	0.2	1.4	-0.5	0.0	0.6	-0.1	-0.2	0.2	-0.1	0.3	0.3	1.2	-0.2
Overall health rating	0.4	0.9	1.7	-0.5	-0.8	1.2	-0.6	-1.1	1.3	-1.3	0.6	-1.0	-0.3	-0.8
Chest pain or discomfort	0.7	1.0	4.5	-0.7	2.0	0.0	0.4	-0.3	0.5	-0.8	0.9	0.3	2.1	-0.0
Had major operations	0.2	0.3	2.0	0.4	0.0	-0.4	-0.1	0.0	-0.4	0.3	-0.7	-0.3	-1.4	0.0
Age at last live birth	0.1	0.1	0.3	0.4	-0.3	-0.2	0.3	0.5	-0.3	0.5	-0.2	0.4	0.2	0.4
Family relationship satisfaction	1.7	2.0	3.1	1.2	1.5	-1.4	1.5	1.4	-1.6	1.7	1.1	1.7	0.9	1.4
Leg pain on walking	0.6	0.7	1.5	-1.0	-0.5	0.0	-1.1	-1.2	1.0	-1.2	0.1	-1.0	0.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.8	-0.5	1.4	0.1	0.9	0.2	-0.2	-0.1	0.3	0.7	2.0	0.3
Commuting to job workplace: Car/motor vehicle	2.5	2.9	6.9	1.5	2.6	-1.5	1.8	1.7	-2.3	1.9	0.4	1.8	0.5	1.4
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	4.2	1.5	0.5	-1.5	1.8	1.9	-2.0	2.0	0.1	1.9	0.9	1.8
Medication: Aspirin	0.9	1.2	2.3	-0.9	-0.2	1.0	-1.2	-1.5	1.2	-1.2	-0.3	-1.5	-0.9	-1.2
Supplements: Vitamin C	0.8	0.9	1.7	-1.0	-0.3	0.8	-1.3	-1.1	0.8	-1.3	-0.8	-1.1	-0.3	-1.1
Knee pain experienced in last month	0.1	0.1	0.5	0.1	0.3	0.1	-0.2	0.1	-0.2	-0.1	0.5	-0.0	-0.7	-0.2
Hypertension (Self-reported)	3.4	9.4	16.0	-3.6	-2.9	3.4	-3.0	-3.6	4.0	-3.7	-1.0	-2.9	1.1	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-1.0	-0.2	0.0	-0.8	-1.2	1.2	-0.9	-0.6	-1.0	0.3	-1.0
Illnesses of father: Heart disease	1.5	2.1	3.1	-1.7	-1.4	1.8	-1.5	-1.5	1.5	-1.4	-1.5	-1.2	0.2	-1.5
Illnesses of siblings: Diabetes	2.6	3.2	5.4	-2.1	-1.2	1.3	-1.9	-2.0	1.9	-2.3	-2.0	-2.0	-0.2	-1.9
Smoking status: Previous	0.7	1.0	1.8	1.1	0.7	-1.2	1.0	1.1	-1.1	1.4	0.2	1.1	0.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.6	1.1	1.9	-1.4	1.5	1.3	-1.3	1.5	1.1	1.4	0.5	1.0
Whole body fat-free mass	0.3	1.6	6.1	-0.1	2.5	-0.1	0.5	0.5	-0.6	0.9	1.8	1.4	2.2	0.4
Leg fat-free mass (right)	0.3	1.3	6.8	-0.7	1.8	0.2	0.1	-0.0	0.1	0.3	1.8	1.0	2.6	0.1
Arm fat percentage (left)	0.9	3.6	7.6	-2.8	0.1	1.0	-1.8	-2.5	2.3	-2.4	0.7	-1.7	1.9	-1.8
Average weekly red wine intake	1.6	2.3	4.2	-1.8	-1.9	1.5	-1.6	-1.7	2.0	-1.4	-0.9	-1.3	0.5	-1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	1.2	-0.2	0.6	0.4	1.0	-1.0	0.8	-0.0	0.5	-1.0	0.8
Mood swings	0.5	1.0	2.8	1.3	0.0	-1.1	0.5	1.0	-0.9	0.6	1.7	1.0	0.1	1.3
Loneliness, isolation	4.2	5.9	10.1	2.2	3.2	-1.6	2.4	2.3	-2.6	2.3	2.6	2.7	1.7	2.6
Long-standing illness, disability or infirmity	0.5	0.8	1.9	-0.4	-0.1	0.3	-0.9	-1.3	1.1	-1.2	0.6	-1.4	-0.8	-0.8
Ever had bowel cancer screening	0.9	1.0	2.9	0.6	1.7	-0.9	0.8	0.6	-0.7	0.4	1.1	0.9	1.4	1.2
Diabetes diagnosed by doctor	0.6	1.0	2.8	-0.8	-0.3	0.5	-0.9	-1.4	1.2	-1.7	-0.1	-1.4	-0.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.5	-1.0	-1.1	1.0	-1.1	-1.1	1.2	-0.9	0.5	-0.6	0.6	-1.0
Friendships satisfaction	1.7	2.1	4.2	1.0	0.8	-1.0	1.7	1.5	-1.2	1.5	1.2	2.0	1.7	1.7
Qualifications: nursing, teaching	0.2	0.4	1.4	-0.1	0.3	-0.8	0.2	-0.1	0.3	0.3	1.2	0.3	1.2	0.6
Commuting to job workplace: Walk	0.6	0.7	1.4	-0.8	-0.8	0.0	-0.7	-1.2	1.1	-0.8	1.0	-1.0	0.2	-0.8
Eye problems/disorders: Cataract	2.6	3.0	4.0	1.5	1.9	-1.5	2.0	1.7	-1.8	1.7	1.8	2.0	1.4	1.7
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	1.5	0.2	-1.3	1.0	1.0	-0.7	1.3	-0.2	0.4	-1.1	1.1
Medication for cholesterol	0.5	0.8	1.9	0.3	1.2	-1.4	0.5	0.7	-0.6	0.7	0.6	0.9	1.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.4	-1.0	-1.4	1.6	-1.2	-0.8	1.2	-0.6	-0.3	-0.8	-0.1	-0.6
Back pain experienced in last month	5.5	8.0	12.8	3.5	3.2	-2.7	2.5	2.9	-3.6	3.3	2.3	2.6	-0.8	2.8
Mineral and other dietary supplements	0.6	0.8	2.9	-1.1	-0.1	1.7	-0.5	-1.1	1.0	-0.8	-0.3	-0.7	0.6	-0.8
Breast cancer (self-reported)	2.2	2.6	6.9	-0.6	-2.6	1.6	-1.3	-0.9	1.1	-1.0	-2.2	-1.5	-2.2	-1.4
Asthma (self-reported)	2.9	5.7	9.4	2.2	3.1	-1.5	3.0	2.6	-2.7	2.4	1.6	2.7	1.4	2.4
Osteoporosis (self-reported)	0.2	0.3	1.1	-0.4	-0.1	1.0	-0.5	-0.2	0.3	-0.9	-0.2	-0.2	0.5	-0.0
Osteoarthritis (self-reported)	0.1	0.1	0.6	-0.2	-0.6	0.4	0.2	-0.1	0.3	-0.3	0.2	0.1	0.8	0.3
Medication: Aspirin	1.1	1.5	2.4	-1.0	-0.7	1.3	-1.4	-1.5	1.2	-1.3	-0.7	-1.6	-0.9	-1.4
Medication: Gliclazide	3.5	3.9	6.3	-1.5	-2.3	1.3	-2.2	-2.2	2.4	-2.3	-1.0	-2.5	-1.6	-2.0
Illnesses of father: None of the above (group 1)	3.3	4.0	8.0	1.9	2.7	-2.8	2.4	1.9	-2.2	2.0	1.4	1.8	-0.2	1.4
Smoking status: Current	1.4	2.2	4.7	2.2	1.4	-1.6	1.4	1.6	-1.6	1.6	0.9	1.1	-0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.4	11.4	20.7	-2.8	-4.5	3.7	-3.3	-3.2	3.9	-3.3	-2.9	-3.6	-1.8	-3.3
Whole body water mass	0.2	1.4	5.2	-0.3	2.3	-0.0	0.3	0.4	-0.4	0.7	1.7	1.2	2.1	0.3
Leg predicted mass (right)	0.3	1.4	7.1	-0.8	1.9	0.2	0.1	-0.1	0.1	0.2	1.7	1.0	2.7	0.1
Arm fat mass (left)	0.6	2.3	5.0	-2.2	1.0	0.6	-1.3	-1.9	1.6	-1.7	1.3	-0.9	2.2	-1.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	-0.6	-0.6	1.0	-0.6	-1.1	1.2	-1.2	0.4	-1.0	0.4	-0.4
Average weekly champagne plus white wine intake	0.4	0.5	1.7	-0.3	1.0	-1.2	0.1	-0.2	0.3	-0.6	0.9	0.0	1.3	0.4
Miserableness	1.3	2.2	7.7	1.2	1.3	-0.6	0.8	1.2	-1.0	0.9	2.8	1.7	1.7	1.9
Guilty feelings	0.4	0.6	2.0	0.8	-1.4	0.5	0.7	0.9	0.0	0.7	0.3	0.9	0.2	1.0
Wears glasses or contact lenses	1.4	1.6	3.8	0.9	1.7	-1.0	1.2	0.8	-1.0	1.0	1.9	1.3	1.2	1.3
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.0	0.6	-0.9	0.4	-0.2	0.2	0.0	0.7	0.2	0.6	-0.1
Hearing aid user	0.6	0.6	1.4	0.5	0.9	-1.2	0.5	0.6	-1.2	0.7	0.7	0.8	0.7	0.8
Mother’s age at death	1.6	2.0	5.2	1.7	0.9	-2.3	1.4	1.6	-1.7	1.6	-0.0	1.3	-0.3	1.2
Financial situation satisfaction	0.3	0.4	2.0	0.3	-0.8	-0.2	-0.0	-0.1	0.2	0.1	-1.2	-0.5	-1.4	-0.3
Tinnitus: Yes, now most or all of the time	2.6	3.0	4.9	1.6	1.5	-2.1	2.2	1.7	-1.3	1.3	2.0	1.9	1.4	1.9
Commuting to job workplace: Public transport	9.6	11.4	19.0	-3.7	-4.4	4.3	-3.3	-3.4	4.1	-3.1	-2.0	-3.1	0.0	-3.5
Eye problems/disorders: Glaucoma	0.6	0.8	3.4	-0.1	-1.8	1.6	-0.7	-0.3	0.9	-0.7	-0.3	-0.4	-0.6	-0.3
Medication: Blood pressure	1.4	2.7	4.0	-1.7	-1.6	2.0	-1.7	-1.8	1.9	-1.6	-0.8	-1.6	-0.3	-2.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	0.7	1.0	-0.5	1.4	0.9	-0.7	1.2	1.4	1.4	1.2	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.5	0.7	-1.2	-1.3	-0.6	0.2	-0.1	0.3	-0.3	-0.4	-1.6	0.2
High cholesterol (Self-reported)	3.4	6.0	9.1	-2.1	-2.2	2.2	-2.9	-2.6	2.6	-2.8	-1.9	-3.0	-1.7	-2.5
Medication: Bendroflumethiazide	1.5	2.2	4.2	-2.1	-0.9	1.0	-1.6	-1.9	1.5	-1.9	-0.9	-1.5	0.9	-1.6
Medication: Paracetamol	5.0	7.7	11.9	-3.1	-1.7	3.4	-3.1	-3.0	2.5	-2.8	-2.9	-3.0	-1.1	-2.9
Medication: Lisinopril	2.7	3.5	5.7	-1.4	-1.9	1.3	-2.4	-2.3	1.8	-2.2	-1.3	-2.4	-1.0	-1.9
Medication: Atorvastatin	0.6	0.8	1.6	-0.7	0.5	-0.1	-0.9	-1.2	1.0	-1.1	0.0	-1.3	-0.6	-1.1
Illnesses of father: High blood pressure	0.6	0.8	2.4	-0.4	-1.6	0.1	-0.9	-0.9	1.2	-0.7	0.4	-1.1	-0.6	-0.5
Alcohol drinker status: Never	1.4	1.7	3.6	0.8	1.2	-0.7	1.4	1.2	-1.3	0.9	1.6	1.7	1.9	1.0
Ever smoked	1.1	1.9	3.8	2.0	0.5	-0.9	1.6	1.7	-1.4	1.9	0.6	1.5	-0.4	1.6
Basal metabolic rate	0.3	1.6	5.8	-0.3	2.4	-0.1	0.3	0.3	-0.4	0.7	1.8	1.2	2.3	0.3
Leg fat percentage (left)	0.3	1.2	2.1	-1.4	0.9	0.1	-0.6	-1.4	1.1	-1.2	1.3	-0.9	1.4	-0.8
Arm fat-free mass (left)	0.3	1.4	5.4	-0.3	2.3	-0.1	0.3	0.3	-0.4	0.7	1.7	1.2	2.1	0.2
Number of operations (self-reported)	0.1	0.2	0.6	0.5	0.6	0.0	0.3	0.3	-0.6	0.2	0.2	0.1	-0.8	0.0
Average weekly beer plus cider intake	0.2	0.2	0.9	-0.2	-0.8	0.9	-0.3	0.2	-0.1	-0.2	-0.8	0.0	0.0	0.0
Irritability	1.3	2.2	5.0	2.1	-0.3	-0.9	1.5	1.7	-1.5	1.8	0.5	1.6	-0.2	2.2
Risk taking	1.0	1.5	2.3	-1.2	-0.2	1.4	-1.4	-1.5	1.4	-1.0	1.5	-0.8	0.8	-1.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.7	0.1	0.4	0.2	0.7	0.4	-0.1	0.3	0.1	0.7	1.3	0.5
Fractured/broken bones in last 5 years	1.5	1.9	4.3	-1.1	-2.1	2.0	-1.4	-1.3	1.8	-1.3	-0.2	-1.3	-0.3	-1.1
Age started oral contraceptive pill	4.4	5.5	9.1	-3.0	-2.8	1.8	-2.3	-2.7	2.7	-2.5	-2.2	-2.2	0.8	-2.2
Diastolic blood pressure, automated reading	5.2	16.1	26.5	-5.2	-2.8	3.2	-4.4	-5.1	4.8	-4.7	-1.6	-4.4	0.7	-4.4
Ever depressed for a whole week	0.3	0.3	1.6	-0.2	0.5	-0.2	-0.1	0.0	0.2	0.1	1.3	0.4	1.1	0.4
Unable to work because of sickness or disability	0.4	0.5	2.9	0.7	-0.3	-0.9	-0.6	-0.0	-0.3	-0.0	0.3	-0.6	-1.7	0.2
Commuting to job workplace: Cycle	1.5	1.9	3.5	-1.4	-1.6	1.1	-1.9	-1.3	1.4	-1.6	-0.9	-1.6	-0.6	-1.2
Myopia	0.3	0.4	1.3	-0.7	-0.8	-0.1	-0.0	-0.5	1.2	-0.6	-0.4	-0.4	0.9	-0.3
Vascular/heart problems diagnosed by doctor	3.5	9.6	16.2	3.6	2.7	-3.3	3.1	3.7	-4.0	3.7	1.1	3.1	-0.7	3.1
Cholesterol lowering medication	2.3	3.4	4.6	-1.8	-1.5	2.0	-1.7	-2.0	2.1	-2.1	-1.5	-2.1	-1.0	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	3.3	-1.3	-1.4	0.8	-1.7	-1.6	1.3	-1.4	-1.7	-1.8	-1.1	-1.6
Pain experienced in last month	0.3	0.5	3.7	-0.6	0.1	0.6	0.3	0.1	0.1	-0.3	-0.5	0.4	1.9	0.4
Supplements: Calcium	0.2	0.2	0.5	-0.3	0.7	-0.1	-0.4	-0.5	-0.0	-0.5	-0.6	-0.7	-0.6	-0.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.8	-1.0	-0.7	0.9	-1.5	-1.1	1.0	-0.9	-0.8	-1.2	-1.3	-1.7
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.5	-0.5	-0.3	1.0	-1.1	-1.2	1.1	-1.0	0.9	-1.1	-0.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.6	1.3	0.3	-1.1	0.3	0.8	-0.7	0.9	1.6	0.8	-0.1	1.1
Heart disease (siblings)	0.7	0.9	1.9	-0.8	-0.8	0.6	-0.7	-1.4	1.4	-1.3	-0.1	-1.2	-0.3	-0.8
Alcohol drinker status: Previous	0.2	0.3	0.8	-0.0	0.3	0.7	-0.5	-0.6	0.3	-0.6	0.9	-0.7	-0.3	-0.2
Pack years of smoking	1.1	1.6	3.2	1.5	0.7	0.2	1.8	1.3	-1.3	1.3	1.6	1.5	0.2	1.3
Impedance of whole body	0.5	2.3	5.5	1.7	1.4	-2.4	2.0	1.4	-1.8	1.4	0.3	1.1	-0.2	1.6
Leg fat mass (left)	0.3	1.3	4.4	-1.1	1.7	-0.2	-0.3	-1.0	0.7	-0.7	1.8	-0.2	2.1	-0.4
Arm predicted mass (left)	0.2	1.1	5.1	-0.4	2.2	-0.0	0.2	0.2	-0.3	0.6	1.5	1.0	1.9	0.1